WO2015141422A1 - Blood collecting device and method of manufacturing blood collecting device - Google Patents
Blood collecting device and method of manufacturing blood collecting device Download PDFInfo
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- WO2015141422A1 WO2015141422A1 PCT/JP2015/055500 JP2015055500W WO2015141422A1 WO 2015141422 A1 WO2015141422 A1 WO 2015141422A1 JP 2015055500 W JP2015055500 W JP 2015055500W WO 2015141422 A1 WO2015141422 A1 WO 2015141422A1
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- Prior art keywords
- tube
- blood collection
- blood
- width
- chuck
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1475—Inlet or outlet ports
- A61J1/1487—Inlet or outlet ports with friction fit, e.g. connecting tubes directly to a protruding port
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1462—Containers with provisions for hanging, e.g. integral adaptations of the container
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
Definitions
- the present invention relates to a blood collection device having a blood collection bag for storing blood collected from a blood collection needle through a tube, and a method for manufacturing the blood collection device.
- Patent Documents 1 and 2 a blood collection needle for collecting blood from a donor, a blood collection bag for storing the collected blood, one end connected to a blood collection bag and the other end to a blood collection needle or a sealing member, A blood collection device having a tube for introducing the collected blood into a blood collection bag is disclosed.
- JP 2004-89495 A Japanese Patent Laid-Open No. 2001-17539
- the blood collection device as described above is manufactured by filling a blood collection bag and a tube with a chemical solution such as an anticoagulant, a blood preservation solution, or a red blood cell preservation solution.
- a chemical solution such as an anticoagulant, a blood preservation solution, or a red blood cell preservation solution.
- a blood collection needle or a sealing member is connected to the tube to close the tube, the operator may accidentally crush the tube. Then, the drug solution leaks from the tube and flows into a hub or sealing member that connects the blood collection needle and the tube, or attaches to the operator's hand, thereby adhering to the outer surface of the blood collection device. There is a fear.
- glucose is contained in the above chemical solution. Therefore, when the blood collection device is subsequently sterilized and stored, the chemical solution adhering to the hub or the sealing member is dried or the chemical solution adhering to the outer surface of the blood collection device is dried. There is a possibility that.
- the drug solution adheres to the hub or sealing member of the blood collection needle or the outer surface of the blood collection device, and the adhesion
- the phenomenon that the portion is discolored occurs, the appearance is poor, and the commercial value of the blood collection device is reduced. Since such a product is not a product, the yield of the product is reduced.
- the present invention has been made to solve the above-described problems, and provides a blood collection instrument and a method for producing the blood collection instrument that can prevent the occurrence of defects such as poor appearance during production, With the goal.
- a blood collection bag for storing collected blood an end connection member whose one end is openably sealed, and the other end is A tube connected to the blood collection bag, and in a blood collection instrument having a drug solution in the blood collection bag and in the tube, a space is formed inside one end of the tube, The width of the tube in the central axis direction is 10 mm to 80 mm.
- the space is sufficiently formed inside one end of the tube. Therefore, when an end connection member is connected to one end of the tube at the time of manufacturing a blood collection device, even if an operator accidentally crushes the tube, the liquid medicine injected into the tube leaks from the tube. There is no risk of adhering to the inside of the end connection member or the outer surface of the blood collection device. Therefore, it is possible to prevent problems such as poor appearance during the production of the blood sampling device. Therefore, the yield of the product for blood collection is improved.
- the end connection member preferably includes a blood collection needle and a hub that connects the tube and the blood collection needle.
- the end connection member includes a sealing member connected to the tube and a first tube connected to the sealing member, and the sealing member includes the tube and the first It is preferable that the tube can be blocked and communicated.
- a blood collection bag for storing collected blood and an end connection member whose one end is openably sealed, and the other end
- the injection nozzle inserted into one end of the tube
- the injection nozzle inserted into one end of the tube
- the tube is crushed by the first gripping tool so as to be crushed in the radial direction of the tube.
- the nozzle retracting step is performed and the tube is released from the state of being gripped by the first gripping tool, while the width of the tube in the central axis direction is the center gripping direction of the tube in the first gripping tool.
- a chuck gripping step in which the tube is gripped by a second gripping tool smaller than the width so as to be crushed in the radial direction of the tube, whereby the width of the tube in the central axis direction is increased;
- An end connecting member connecting step in which the end connecting member is connected to one end of the tube while the tube is held by two gripping tools. Still further, in the above aspect, the width of the space is 10 mm to 80 mm when the chuck holding step is completed.
- a sufficient space is formed inside the one end portion of the tube when the chuck holding step is completed. Therefore, even if the operator accidentally crushes the tube when the end connection member connection step is performed, the chemical injected into the tube leaks out of the tube and is used in the end connection member or for blood collection. There is no risk of sticking to the outer surface of the instrument. For this reason, it is possible to prevent the occurrence of defects such as poor appearance during the manufacture of the blood sampling device. Therefore, the yield of the product for blood collection is improved.
- the timing at which the tube is released from the state of being gripped by the first gripping tool is the same as the timing at which the tube is gripped by the second gripping tool, or It is preferable that it is after the timing when the tube is gripped by the second gripping tool.
- the chemical solution injected into the tube can be reliably replaced from the first gripper to the second gripper without leaking from the tube.
- the width of the space inside the tube is more effectively expanded in the chuck re-holding process.
- the end connection member preferably includes a blood collection needle and a hub that connects the tube and the blood collection needle.
- the end connection member includes a sealing member connected to the tube and a first tube connected to the sealing member, and the sealing member includes the tube and the first It is preferable that the tube can be blocked and communicated.
- the blood collecting instrument and the method for producing a blood collecting instrument of the present invention it is possible to prevent the occurrence of problems such as poor appearance when the blood collecting instrument is manufactured.
- FIG. 1 is a plan view of a blood collection device of Example 1.
- 6 is a plan view of a blood collection device of Example 2.
- FIG. In the blood collection instrument of Example 2 it is an enlarged view of the periphery of the one end part of a tube. It is a figure which shows a sealing member connection process.
- the blood collection instrument 1 of this embodiment includes a blood collection bag 10, a tube 12, a sealing member 14, a tube 16, a hub 18, a blood collection needle 20, a cap 22, and the like. .
- the hub 18 fixes the blood collection needle 20 and is connected to the tube 12.
- the cap 22 covers the blood collection needle 20, the tube 12 is sealed.
- the hub 18, the blood collection needle 20 and the cap 22 constitute an example of the “end connection member” of the present invention.
- the blood collection bag 10 is a bag for storing collected blood.
- the blood collection bag 10 has a bag body 30 configured in a bag shape.
- the bag body 30 is formed by stacking resin-made flexible sheet materials and fusing (thermal fusing, high-frequency fusing, etc.) or bonding at the peripheral seal portion 32.
- a blood storage portion 34 for storing blood sampled blood is formed in an inner portion surrounded by the seal portion 32 of the bag body 30.
- the liquid chemical liquid 24, which is a chemical liquid is stored (accommodated).
- the drug solution 24 include ACD (acid citrate dextrose), CPD solution (cytolate phosphate dextrose), MAP solution, SAGM solution, OPTISOL solution, and the like. The amount of the drug solution 24 is adjusted to an appropriate amount according to the planned blood collection amount.
- the bag body 30 has a discharge port 36 at the top thereof.
- the discharge port 36 is sealed so that it can be opened, and two discharge ports 36 are provided.
- a sealing member 14 is provided on the side of one discharge port 36.
- the sealing member 14 is connected to one end of a tube 16 having flexibility.
- the bag body 30 is connected to the other end portion 12b of the tube 12 having flexibility. Note that the inside of each of the discharge port 36, the tube 12, and the sealing member 14 communicates with the blood storage portion 34.
- the tube 12 is connected to the blood collection needle 20 through the hub 18 at one end 12a. Further, the tube 12 is connected at the other end 12b so as to communicate with the bag body 30 of the blood collection bag 10.
- the tube 12 is formed in a cylindrical shape, and has a flow path for introducing blood collected by the blood collection needle 20 into the blood collection bag 10 therein.
- the chemical solution 24 is injected into the tube 12.
- the tube 12 is an example of the “tube” in the present invention.
- the hub 18 is connected to the tube 12 and the blood collection needle 20.
- the hub 18 is fitted with a cap 22 that covers the blood collection needle 20 and can be opened by removing the cap 22.
- These tubes 12, hub 18, blood collection needle 20 and cap 22 constitute a blood collection line.
- one or more bags such as a plasma bag (not shown), a buffy coat bag, a platelet bag (medicine solution storage bag), and the like may be provided on the other end side of the tube 16. That is, the blood collection instrument 1 may constitute a bag connector.
- the composition, characteristics, etc. of the sheet material constituting the bag body 30 of the blood collection bag 10 are not particularly limited.
- the constituent material of the sheet material of the blood collection bag 10 is a material mainly composed of soft polyvinyl chloride or soft polyvinyl chloride (for example, a copolymer with a small amount of other polymer material, a polymer blend, a polymer alloy). Etc.) is preferred.
- the plasticizer in the soft polyvinyl chloride for example, di-2-ethylhexyl phthalate (DEHP), dinormaldecyl phthalate (DnDP) and the like are preferable.
- the content of the plasticizer in the sheet material is preferably about 25 to 50 wt%, more preferably about 30 to 40 wt%.
- the sheet material as described above can be manufactured, for example, by the following method.
- a predetermined material is sufficiently kneaded using a kneader, the kneaded product is extruded through a T die or a circular die, and the obtained flat sheet-like material is subjected to thermoforming, blowing, stretching, cutting, and cutting. Steps such as part sealing (fusion) are sequentially performed to form a desired shape and form.
- the surface of a sheet (base material) can be roughened (embossed), or an anti-blocking agent, a slip agent, etc. can be added or applied.
- thermoplastic elastomers such as soft polyvinyl chloride, polyethylene, polypropylene, ethylene-vinyl acetate copolymer, styrene-butadiene-styrene copolymer, and the like.
- soft polyvinyl chloride or a material mainly composed of this is preferable.
- each tube is made of soft polyvinyl chloride, sufficient flexibility and softness can be obtained, so that it is easy to handle and suitable for clogging with a clamp or the like.
- the tube made of soft polyvinyl chloride is excellent in compatibility with the bag material of the same main material, so when joining them by fusion or adhesion, the joint strength is high and the air tightness is excellent. It is preferable for maintaining durability and sterility against the centrifugation operation.
- the kind of plasticizer used for each tube and its content are not specifically limited.
- a blood processing method using the blood collection device 1 will be described as an action of the blood collection device 1.
- the cap 22 is removed from the hub 18 and puncture is performed with a blood collection needle 20 into a vein (blood vessel) of a donor (blood donor).
- the collected blood flows through the tube 12 and is introduced into the blood storage part 34 in which the drug solution 24 is injected in the blood collection bag 10. In this way, blood is collected in the blood collection bag 10.
- the configuration of the one end portion 12a of the tube 12 will be described.
- the drug solution 24 is injected into the tube 12, but an air replacement unit 40, which is a space, is provided inside the one end 12 a connected to the blood collection needle 20 via the hub 18. Is formed.
- the air replacement part 40 is formed from the tip of the end 12a of the tube 12 to which the blood collection needle 20 is connected (right side in FIG. 2) to the other end 12b side (left side in FIG. 2).
- the width ⁇ of the one end portion 12a is 80 mm
- the width ⁇ of the air replacement portion 40 is 10 mm to 80 mm. Both the width ⁇ and the width ⁇ are widths in the central axis direction of the tube 12 (left and right direction in FIG. 2).
- the width ⁇ in the axial direction of the air replacement part 40 is preferably 10 mm to 80 mm, and more preferably 15 mm to 60 mm.
- the width ⁇ is shorter than the lower limit value of the above range, the possibility that the chemical solution in the tube 12 is scattered outside increases, and when the width ⁇ is longer than the upper limit value of the above range, the manufacturing apparatus becomes large.
- the tube 12 includes the air replacement portion 40 in the region of the one end portion 12a defined by the width ⁇ .
- the chuck CH1, the chuck CH2, the chuck CH3, and the injection nozzle N are used when the blood collection instrument 1 is manufactured.
- the width L1 of the chuck CH1 is 7 mm
- the width L2 of the chuck CH2 is 7 mm
- the width L3 of the chuck CH3 is 2 mm
- the width LN of the injection port Na of the injection nozzle N is 5 to 7 mm.
- the width L1, the width L2, the width L3, and the width LN are all widths in the central axis direction of the tube 12.
- pouring nozzle N may be automatically controlled by the control part not shown.
- the chuck CH1 and the chuck CH2 are examples of the “first gripping tool” of the present invention
- the chuck CH3 is an example of the “second gripping tool” of the present invention.
- the sizes of the width L1, the width L2, and the width L3 are not particularly limited to the above numerical values and can be changed.
- the width L3 of the chuck CH3 is smaller than the total width of the width L1 of the chuck CH1 and the width L2 of the chuck CH2.
- a chemical injection process is performed. Specifically, as shown in FIG. 3, the injection port Na of the injection nozzle N is inserted into the one end portion 12 a of the tube 12. Then, the drug solution 24 is injected into the blood storage part 34 of the blood collection bag 10 through the tube 12 from the injection port Na of the injection nozzle N. As a result, the drug solution 24 is injected into the blood collection bag 10 and the tube 12.
- the tube 12 is gripped by the chuck CH ⁇ b> 1 and the chuck CH ⁇ b> 2 so as to be crushed in the radial direction of the tube 12. Further, the inside of the tube 12 is sucked under reduced pressure through the injection nozzle N at one end 12 a of the tube 12.
- the injection port Na of the injection nozzle N is removed from the inside of the one end 12 a of the tube 12 and retreats.
- the air replacement part 40 which is space is formed inside the one end part 12 a of the tube 12.
- the air replacement section 40 is formed from the tip of the end 12a of the tube 12 to which the blood collection needle 20 is connected (right side in FIG. 5) to the other end 12b side (left side in FIG. 5).
- the width ⁇ of the air replacement section 40 is, for example, 5 mm to 7 mm.
- the width ⁇ is the width of the tube 12 in the central axis direction (left-right direction in FIG. 5).
- a chuck grip replacement process is performed. Specifically, as shown in FIG. 6, while the tube 12 is released from the state of being gripped by the chuck CH1 and the chuck CH2, the tube 12 is crushed in the radial direction of the tube 12 by the chuck CH3. Grasped.
- the timing at which the tube 12 is released from the state of being gripped by the chuck CH1 and the chuck CH2 is the same as the timing at which the tube 12 is gripped by the chuck CH3, or the timing at which the tube 12 is gripped by the chuck CH3. Later.
- the width ⁇ of the air replacement unit 40 is 10 mm to 80 mm when the chuck grip replacement process is completed.
- the width ⁇ of the air replacement unit 40 is less than 10 mm.
- the width ⁇ of the air replacement unit 40 can be increased by performing the chuck re-holding step as compared to the case where the chuck re-holding step is not performed.
- a blood collection needle connecting step is performed. Specifically, as shown in FIG. 7, while the tube 12 is gripped by the chuck CH3, the blood collection needle 20 to which the cap 22 is connected is connected to the one end portion 12a of the tube 12 via the hub 18. Thereby, as shown in FIG. 2, the blood collection needle 20 and the cap 22 are connected to the one end portion 12 a of the tube 12 through the hub 18.
- the blood collection needle connecting step is an example of the “end connecting member connecting step” in the present invention.
- the drug solution 24 is injected into the blood collection bag 10 and the tube 12, and then the blood collection needle 20 can be connected to the tube 12. Then, after that, the tube 12 is released from the state of being gripped by the chuck CH3, whereby the configuration of the one end portion 12a of the tube 12 is as shown in FIG. At this time, the width ⁇ of the air replacement part 40 is 10 mm to 80 mm.
- the width LX in the central axis direction of the tube 12 in the chuck CHX is the same as the total width of the width L1 of the chuck CH1 and the width L2 of the chuck CH2.
- the width LX of the chuck CHX is 14 mm.
- the chuck CHX is an example of the “first gripper” in the present invention.
- the air replacement part 40 is formed inside the one end part 12a of the tube 12, and the width ⁇ of the air replacement part 40 is 10 mm to 80 mm.
- the air replacement portion 40 is sufficiently formed inside the one end portion 12 a of the tube 12. Therefore, when the blood collection needle 20 is connected to the one end portion 12a of the tube 12 via the hub 18 when the blood collection device 1 is manufactured, even if the operator accidentally crushes the tube 12, it is injected into the tube 12. There is no possibility that the drug solution 24 leaked from the tube 12 and adheres to the outer surface of the blood sampling device 1. Therefore, it is possible to prevent the occurrence of problems such as poor appearance when the blood collecting instrument 1 is manufactured. Therefore, the product yield of the blood collection instrument 1 is improved.
- the end connection member in the blood collection instrument 1 includes a blood collection needle 20, a hub 18 that connects the tube 12 and the blood collection needle 20, and a cap 22. In this way, it is possible to prevent problems such as poor appearance during the production of the blood collection instrument 1 in which the hub 18 and the blood collection needle 20 are directly connected to the tube 12 connected to the blood collection bag 10.
- the width ⁇ of the air replacement part 40 is 10 mm to 80 mm.
- the air replacement portion 40 is sufficiently formed inside the one end portion 12 a of the tube 12. Therefore, even if the operator accidentally crushes the tube 12 when the blood collection needle connecting step is performed, the drug solution 24 injected into the tube 12 leaks from the tube 12 and the outer surface of the blood collection device 1. There is no risk of sticking to. Therefore, it is possible to prevent the occurrence of problems such as poor appearance when the blood collecting instrument 1 is manufactured. Therefore, the product yield of the blood collection instrument 1 is improved.
- the timing at which the tube 12 is released from the state of being gripped by the chuck CH1 and the chuck CH2 is the same as the timing at which the tube 12 is gripped by the chuck CH3, or the tube 12 is gripped by the chuck CH3. Later than the timing.
- the chemical liquid 24 injected into the tube 12 does not leak from the tube 12, and the chuck CH1 and the chuck CH2 are reliably re-gripped to the chuck CH3, or the chuck CHX. To the chuck CH3.
- Example 2 Next, the second embodiment will be described.
- the same components as those of the first embodiment are denoted by the same reference numerals, the description thereof will be omitted, and different points will be mainly described.
- the blood collection device 2 of Example 2 is different from the blood collection device 1 of Example 1 in that the sealing member 50, the branch connector 52, the tube 54, the tube 56, and the clamp 58, a temporary storage bag 60, a tube 62, a sampling port 64, and the like.
- the sealing member 50 is connected to the one end 12 a of the tube 12.
- the sealing member 50, the branch connector 52, the tube 54, the hub 18, the blood collection needle 20, the cap 22, the tube 56, the clamp 58, the temporary storage bag 60, and the tube 62 and the sampling port 64 constitute an example of the “end connection member” of the present invention.
- the sealing member 50 is connected to the tube 12 so that it can be opened.
- the sealing member 50 has a structure as shown in FIG. 10, and can block and communicate between the tube 12 and the tube 54.
- the sealing member 50 includes a short tube 70 and a cylindrical body 72.
- the short tube 70 is made of a flexible resin such as soft polyvinyl chloride.
- the cylindrical body 72 is closed at one end by a solid columnar portion 74.
- One end portion 12a of the tube 12 is connected to the left end portion of the short tube 70 in FIG. Further, the tube 54 is connected to the right end of the short tube 70 in FIG. In the state shown in FIG. 10, the tube 12 and the tube 54 are blocked by the cylindrical body 72.
- a thin and fragile fracture portion 76 is formed on the outer periphery of the cylindrical body 72.
- the broken column 76 is broken by folding the solid columnar portion 74 together with the short tube 70 from the outside of the short tube 70 with fingers or the like, the solid columnar portion 74 is separated from the cylindrical body 72. As a result, the tube 12 and the tube 54 communicate with each other.
- the branch connector 52 is connected to a tube 54 and a tube 56.
- the tube 54 is connected to the blood collection needle 20 through the hub 18 at one end thereof.
- the tube 54 is connected to the sealing member 50 at the other end.
- the tube 54 is an example of the “first tube” in the present invention.
- the hub 18 connects the tube 54 and the blood collection needle 20. Further, the tube 54 may be connected at one end thereof to various bags such as a bag containing a red blood cell storage solution.
- the tube 56 branches off from the tube 54 at the branch connector 52 portion at one end thereof.
- the tube 56 is connected to the temporary storage bag 60 via the clamp 58 at the other end.
- the tube 56 is an example of the “second tube” in the present invention.
- the temporary storage bag 60 is a bag that is connected to the other end of the tube 56 and temporarily stores the collected blood.
- This temporary storage bag 60 is made of, for example, a flexible sheet material made of a soft resin such as polyvinyl chloride, which will be described later, and is fused (heat fusion, high frequency fusion, etc.) at the peripheral seal portion 80. Or a bag body 82 which is bonded to form a bag.
- the tube 62 has a temporary storage bag 60 connected to one end and a sampling port (connector) 64 connected to the other end.
- the sampling port 64 is connected to, for example, a holder of a decompression blood collection tube (container) (not illustrated) (a blood collection device for decompression blood collection tube). Collected in a vacuum blood collection tube.
- the cap 22 is removed from the hub 18 and puncture is performed with a blood collection needle 20 into a vein (blood vessel) of a donor (blood donor).
- a blood collection needle 20 into a vein (blood vessel) of a donor (blood donor).
- blood flows from the tube 54 to the tube 56 through the branch connector 52.
- the initial blood flow flows through the blood collection needle 20, the tube 54, and the branch connector 52, flows into the tube 56, and is introduced into the temporary storage bag 60.
- the tube 56 is closed by the clamp 58, and the flow path of the tube 56 is closed (blocked).
- the tube 12 and the tube 54 communicate with each other. . Thereby, the collected blood flows through the tube 54 and the tube 12 and is introduced into the blood storage part 34 of the blood collection bag 10. In this way, blood is collected in the blood collection bag 10.
- the configuration of the one end portion 12a of the tube 12 will be described.
- the chemical liquid 24 is injected into the tube 12, but an air replacement portion 40 that is a space is formed inside the one end portion 12 a connected to the sealing member 50.
- the width ⁇ of the one end portion 12a is 80 mm
- the width ⁇ of the air replacement portion 40 is 10 mm to 80 mm.
- a sealing member connecting step is performed instead of the blood collection needle connecting step.
- the sealing member 50 is connected to the one end portion 12a of the tube 12 while the tube 12 is gripped by the chuck CH3.
- the blood collection needle 20 and the temporary storage bag 60 are connected to the one end portion 12 a of the tube 12 via the sealing member 50.
- the sealing member connecting step is an example of the “end connecting member connecting step” in the present invention.
- the blood collecting device 1 and the blood collecting device 2 manufactured by injecting the drug solution 24 into the blood collecting bag 10 and the tube 12 and then connecting the blood collecting needle 20 to the tube 12 are sterilized, The occurrence of appearance defects was evaluated. Then, 200 sets of evaluations were performed on the blood sampling device 1 and 100 sets of evaluations were performed on the blood sampling device 2, but no appearance defects occurred.
- the air replacement part 40 is formed inside the one end part 12a of the tube 12, and the width ⁇ of the air replacement part 40 is 10 mm to 80 mm.
- the air replacement portion 40 is sufficiently formed inside the one end portion 12 a of the tube 12. Therefore, when the sealing member 50 is connected to the one end portion 12a of the tube 12 at the time of manufacturing the blood collection device 2, the drug solution injected into the tube 12 even if the operator accidentally crushes the tube 12 There is no fear that 24 leaks out of the tube 12 and adheres to the outer surface of the blood collection device 2. Therefore, it is possible to prevent the occurrence of problems such as poor appearance when the blood collecting instrument 2 is manufactured. Therefore, the product yield of the blood sampling device 2 is improved.
- the end connection member of the blood sampling instrument 2 includes a sealing member 50 connected to the tube 12 and a tube 54 connected to the sealing member 50, and the sealing member 50 includes the tube 12 and the tube 54. Can be blocked and communicated with each other. In this way, the one end portion 12a of the tube 12 can be connected to various members via the sealing member 50, and problems such as poor appearance occur at the time of manufacturing the blood sampling device 2 having various configurations. Can be prevented.
- the manufacturing method of the blood sampling instrument 2 of the present embodiment includes a chemical solution injection process, a suck back process, a nozzle retraction process, a chuck grip replacement process, and a sealing member connection process.
- the width ⁇ of the air replacement part 40 is between 10 mm and 80 mm.
- the air replacement portion 40 is sufficiently formed inside the one end portion 12 a of the tube 12. Therefore, even if an operator accidentally crushes the tube 12 when the sealing member connecting step is performed, the drug solution 24 injected into the tube 12 leaks out of the tube 12 and the blood collecting instrument 2 There is no risk of adhering to the outer surface. Therefore, it is possible to prevent problems such as poor appearance during the production of the blood sampling device 2. Therefore, the product yield of the blood sampling device 2 is improved.
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- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
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Abstract
A blood collecting device includes a blood collecting bag for storing collected blood, a tube connected at one end to an end connecting member for releasably sealing the one end and connected at the other end to the blood collecting bag, and a medicinal solution in the blood collecting bag and the tube. Space is formed in the one end of the tube, and the space has a width of from 10mm to 80mm in the center axis direction of the tube.
Description
本発明は、採血針からチューブを介して採取された血液を収納する採血バッグを有する採血用器具および採血用器具の製造方法に関する。
The present invention relates to a blood collection device having a blood collection bag for storing blood collected from a blood collection needle through a tube, and a method for manufacturing the blood collection device.
特許文献1,2には、ドナーより血液を採取する採血針と、採取された血液を収納する採血バッグと、一端部が採血バッグに他端部が採血針または封止部材にそれぞれ接続し、採取された血液を採血バッグへ導入するチューブと、を有する採血用器具が開示されている。
In Patent Documents 1 and 2, a blood collection needle for collecting blood from a donor, a blood collection bag for storing the collected blood, one end connected to a blood collection bag and the other end to a blood collection needle or a sealing member, A blood collection device having a tube for introducing the collected blood into a blood collection bag is disclosed.
しかしながら、前記のような採血用器具は採血バッグとチューブに抗凝固剤、血液保存液、又は赤血球保存液等の薬液を充填して製造されるが、採血バッグとチューブに上記薬液を充填した後にチューブに採血針や封止部材を接続してチューブを閉塞するときに、作業者が誤ってチューブを押し潰すおそれがある。そうすると、上記薬液が、チューブから漏れ出て、採血針とチューブとを接続するハブや封止部材に流入したり、作業者の手に付いたりなどすることにより、採血用器具の外面に付着するおそれがある。
However, the blood collection device as described above is manufactured by filling a blood collection bag and a tube with a chemical solution such as an anticoagulant, a blood preservation solution, or a red blood cell preservation solution. When a blood collection needle or a sealing member is connected to the tube to close the tube, the operator may accidentally crush the tube. Then, the drug solution leaks from the tube and flows into a hub or sealing member that connects the blood collection needle and the tube, or attaches to the operator's hand, thereby adhering to the outer surface of the blood collection device. There is a fear.
ここで、上記薬液には、ブドウ糖が含まれている。そのため、その後、採血用器具を滅菌処理、及び保管する際に、ハブや封止部材に流入したり、採血用器具の外面に付着した上記薬液が乾燥することにより、上記薬液の付着部分が褐変してしまう可能性がある。このように薬剤を導入された状態で商品として製造されるシステムに薬剤入りチューブを組み込む際、採血針のハブや封止部材内、又は採血用器具の外面に薬液が付着し、また、その付着部分が変色する現象が発生すると外観不良となり、採血用器具の商品価値が低下してしまう。このような製品は商品とはならないので、製品の歩留まりが低下してしまう。また、薬液が採血用器具の外面に付着することは、衛生上も好ましくない。
Here, glucose is contained in the above chemical solution. Therefore, when the blood collection device is subsequently sterilized and stored, the chemical solution adhering to the hub or the sealing member is dried or the chemical solution adhering to the outer surface of the blood collection device is dried. There is a possibility that. When incorporating a drug-containing tube into a system that is manufactured as a product with the drug introduced in this way, the drug solution adheres to the hub or sealing member of the blood collection needle or the outer surface of the blood collection device, and the adhesion When the phenomenon that the portion is discolored occurs, the appearance is poor, and the commercial value of the blood collection device is reduced. Since such a product is not a product, the yield of the product is reduced. In addition, it is not preferable from the viewpoint of hygiene that the chemical solution adheres to the outer surface of the blood sampling device.
そこで、本発明は上記した問題点を解決するためになされたものであり、製造時にて外観不良などの不具合が発生することを防止できる採血用器具および採血用器具の製造方法を提供すること、を目的とする。
Therefore, the present invention has been made to solve the above-described problems, and provides a blood collection instrument and a method for producing the blood collection instrument that can prevent the occurrence of defects such as poor appearance during production, With the goal.
上記課題を解決するためになされた本発明の一態様は、採取された血液を収納する採血バッグと、一端部が開封可能に封止する端部接続部材に接続し、かつ、他端部が前記採血バッグに接続するチューブと、を有し、薬液を前記採血バッグの内部と前記チューブの内部とに有する採血用器具において、前記チューブの一端部の内部に空間が形成され、前記空間の前記チューブの中心軸方向の幅は10mm~80mmであること、を特徴とする。
One aspect of the present invention made to solve the above problems is that a blood collection bag for storing collected blood, an end connection member whose one end is openably sealed, and the other end is A tube connected to the blood collection bag, and in a blood collection instrument having a drug solution in the blood collection bag and in the tube, a space is formed inside one end of the tube, The width of the tube in the central axis direction is 10 mm to 80 mm.
この態様によれば、チューブの一端部の内部に空間が十分に形成されている。そのため、採血用器具の製造時にチューブの一端部に端部接続部材を接続するときに、作業者が誤ってチューブを押し潰しても、チューブの内部に注入されている薬液がチューブから漏れ出て端部接続部材内、又は採血用器具の外面に付着するおそれがない。したがって、採血用器具の製造時にて、外観不良などの不具合が発生することを防止できる。ゆえに、採血用器具の製品の歩留まりが向上する。
According to this aspect, the space is sufficiently formed inside one end of the tube. Therefore, when an end connection member is connected to one end of the tube at the time of manufacturing a blood collection device, even if an operator accidentally crushes the tube, the liquid medicine injected into the tube leaks from the tube. There is no risk of adhering to the inside of the end connection member or the outer surface of the blood collection device. Therefore, it is possible to prevent problems such as poor appearance during the production of the blood sampling device. Therefore, the yield of the product for blood collection is improved.
上記の態様においては、前記端部接続部材は、採血針と、前記チューブと前記採血針とを接続するハブと、を備えていること、が好ましい。
In the above aspect, the end connection member preferably includes a blood collection needle and a hub that connects the tube and the blood collection needle.
この態様によれば、採血バッグに接続するチューブに直接的にハブと採血針とが接続している採血用器具の製造時にて、外観不良などの不具合が発生することを防止できる。
According to this aspect, it is possible to prevent the occurrence of problems such as poor appearance during the manufacture of a blood collection device in which the hub and the blood collection needle are directly connected to the tube connected to the blood collection bag.
上記の態様においては、前記端部接続部材は、前記チューブに接続する封止部材と、前記封止部材に接続する第1チューブと、を備え、前記封止部材は、前記チューブと前記第1チューブとの間を遮断および連通させることができること、が好ましい。
In the above aspect, the end connection member includes a sealing member connected to the tube and a first tube connected to the sealing member, and the sealing member includes the tube and the first It is preferable that the tube can be blocked and communicated.
この態様によれば、封止部材を介して、種々の部材と接続することができ、種々の構成の採血用器具の製造時にて、外観不良などの不具合が発生することを防止できる。
According to this aspect, it is possible to connect to various members via the sealing member, and it is possible to prevent problems such as poor appearance during the production of blood collection instruments having various configurations.
上記課題を解決するためになされた本発明の他の態様は、採取された血液を収納する採血バッグと、一端部が開封可能に封止する端部接続部材に接続し、かつ、他端部が前記採血バッグに接続するチューブと、を有し、薬液を前記採血バッグの内部と前記チューブの内部とに有する採血用器具の製造方法において、前記チューブの一端部に挿入された注入ノズルから前記薬液が前記採血バッグの内部と前記チューブの内部とに注入される薬液注入工程と、第1把持具により前記チューブが当該チューブの径方向に押し潰されるように把持されながら、前記チューブの一端部にて前記チューブの内部が減圧吸引されるサックバック工程と、前記注入ノズルが前記チューブの一端部から後退することにより、前記チューブの一端部の内部に空間が形成されるノズル後退工程と、前記チューブが前記第1把持具により把持される状態から開放される一方で、前記チューブの中心軸方向の幅が前記第1把持具における前記チューブの中心軸方向の幅よりも小さい第2把持具により前記チューブが当該チューブの径方向に押し潰されるように把持されることにより、前記空間における前記チューブの中心軸方向の幅が拡がるチャック掴み替え工程と、前記第2把持具により前記チューブが把持されながら、前記チューブの一端部に前記端部接続部材が接続される端部接続部材接続工程と、を有すること、を特徴とする。
また、さらに、上記の態様において、前記チャック掴み替え工程が終了したときに、前記空間の前記幅は10mm~80mmであること、を特徴とする。 Another aspect of the present invention made to solve the above-described problems is that a blood collection bag for storing collected blood and an end connection member whose one end is openably sealed, and the other end In the method for manufacturing a blood collection device having a drug solution in the blood collection bag and in the tube, the injection nozzle inserted into one end of the tube One end portion of the tube while the chemical solution is injected into the blood collection bag and the inside of the tube, and the tube is crushed by the first gripping tool so as to be crushed in the radial direction of the tube. In the suck back process in which the inside of the tube is sucked under reduced pressure, and the injection nozzle is retracted from one end of the tube, a space is formed inside the one end of the tube. The nozzle retracting step is performed and the tube is released from the state of being gripped by the first gripping tool, while the width of the tube in the central axis direction is the center gripping direction of the tube in the first gripping tool. A chuck gripping step in which the tube is gripped by a second gripping tool smaller than the width so as to be crushed in the radial direction of the tube, whereby the width of the tube in the central axis direction is increased; An end connecting member connecting step in which the end connecting member is connected to one end of the tube while the tube is held by two gripping tools.
Still further, in the above aspect, the width of the space is 10 mm to 80 mm when the chuck holding step is completed.
また、さらに、上記の態様において、前記チャック掴み替え工程が終了したときに、前記空間の前記幅は10mm~80mmであること、を特徴とする。 Another aspect of the present invention made to solve the above-described problems is that a blood collection bag for storing collected blood and an end connection member whose one end is openably sealed, and the other end In the method for manufacturing a blood collection device having a drug solution in the blood collection bag and in the tube, the injection nozzle inserted into one end of the tube One end portion of the tube while the chemical solution is injected into the blood collection bag and the inside of the tube, and the tube is crushed by the first gripping tool so as to be crushed in the radial direction of the tube. In the suck back process in which the inside of the tube is sucked under reduced pressure, and the injection nozzle is retracted from one end of the tube, a space is formed inside the one end of the tube. The nozzle retracting step is performed and the tube is released from the state of being gripped by the first gripping tool, while the width of the tube in the central axis direction is the center gripping direction of the tube in the first gripping tool. A chuck gripping step in which the tube is gripped by a second gripping tool smaller than the width so as to be crushed in the radial direction of the tube, whereby the width of the tube in the central axis direction is increased; An end connecting member connecting step in which the end connecting member is connected to one end of the tube while the tube is held by two gripping tools.
Still further, in the above aspect, the width of the space is 10 mm to 80 mm when the chuck holding step is completed.
これらの態様によれば、チャック掴み替え工程が終了したときに、チューブの一端部の内部に空間が十分に形成されている。そのため、端部接続部材接続工程が行われるときに、作業者が誤ってチューブを押し潰しても、チューブの内部に注入されている薬液がチューブから漏れ出て端部接続部材内、又は採血用器具の外面に付着するおそれがない。そのため、採血用器具の製造時にて、外観不良などの不具合が発生することを防止できる。したがって、採血用器具の製品の歩留まりが向上する。
According to these aspects, a sufficient space is formed inside the one end portion of the tube when the chuck holding step is completed. Therefore, even if the operator accidentally crushes the tube when the end connection member connection step is performed, the chemical injected into the tube leaks out of the tube and is used in the end connection member or for blood collection. There is no risk of sticking to the outer surface of the instrument. For this reason, it is possible to prevent the occurrence of defects such as poor appearance during the manufacture of the blood sampling device. Therefore, the yield of the product for blood collection is improved.
上記の態様においては、前記チャック掴み替え工程では、前記チューブが前記第1把持具により把持される状態から開放されるタイミングは、前記チューブが前記第2把持具により把持されるタイミングと同時、または、前記チューブが前記第2把持具により把持されるタイミングよりも後であること、が好ましい。
In the above aspect, in the chuck re-holding step, the timing at which the tube is released from the state of being gripped by the first gripping tool is the same as the timing at which the tube is gripped by the second gripping tool, or It is preferable that it is after the timing when the tube is gripped by the second gripping tool.
この態様によれば、チャック掴み替え工程において、チューブの内部に注入されている薬液がチューブから漏れ出ることなく、確実に、第1把持具から第2把持具への掴み替えを行うことができる。
According to this aspect, in the chuck grip replacement step, the chemical solution injected into the tube can be reliably replaced from the first gripper to the second gripper without leaking from the tube. .
上記の態様においては、(前記第1把持具における前記チューブの中心軸方向の幅)-(前記第2把持具における前記チューブの中心軸方向の幅)=5mm~75mmであること、が好ましい。
In the above aspect, it is preferable that (the width in the central axis direction of the tube in the first gripping tool) − (width in the central axis direction of the tube in the second gripping tool) = 5 mm to 75 mm.
この態様によれば、チャック掴み替え工程において、より効果的に、チューブの内部の空間の幅が拡がる。
According to this aspect, the width of the space inside the tube is more effectively expanded in the chuck re-holding process.
上記の態様においては、前記端部接続部材は、採血針と、前記チューブと前記採血針とを接続するハブと、を備えていること、が好ましい。
In the above aspect, the end connection member preferably includes a blood collection needle and a hub that connects the tube and the blood collection needle.
この態様によれば、採血バッグに接続するチューブに直接的にハブと採血針とが接続している採血用器具の製造時にて、外観不良などの不具合が発生することを防止できる。
According to this aspect, it is possible to prevent the occurrence of problems such as poor appearance during the manufacture of a blood collection device in which the hub and the blood collection needle are directly connected to the tube connected to the blood collection bag.
上記の態様においては、前記端部接続部材は、前記チューブに接続する封止部材と、前記封止部材に接続する第1チューブと、を備え、前記封止部材は、前記チューブと前記第1チューブとの間を遮断および連通させることができること、が好ましい。
In the above aspect, the end connection member includes a sealing member connected to the tube and a first tube connected to the sealing member, and the sealing member includes the tube and the first It is preferable that the tube can be blocked and communicated.
この態様によれば、封止部材を介して、種々の部材と接続することができ、種々の構成の採血用器具の製造時にて、外観不良などの不具合が発生することを防止できる。
According to this aspect, it is possible to connect to various members via the sealing member, and it is possible to prevent problems such as poor appearance during the production of blood collection instruments having various configurations.
本発明の採血用器具および採血用器具の製造方法によれば、当該採血用器具の製造時にて外観不良などの不具合が発生することを防止できる。
According to the blood collecting instrument and the method for producing a blood collecting instrument of the present invention, it is possible to prevent the occurrence of problems such as poor appearance when the blood collecting instrument is manufactured.
〔実施例1〕
<採血用器具の構成>
図1に示すように、本実施例の採血用器具1は、採血バッグ10と、チューブ12と、封止部材14と、チューブ16と、ハブ18と、採血針20と、キャップ22などを有する。ハブ18は、採血針20を固定するとともにチューブ12と接続する。キャップ22が採血針20を覆うことにより、チューブ12は封止された状態となる。なお、本実施例においては、ハブ18と採血針20とキャップ22により、本発明の「端部接続部材」の一例が構成されている。 [Example 1]
<Configuration of blood collection device>
As shown in FIG. 1, the blood collection instrument 1 of this embodiment includes ablood collection bag 10, a tube 12, a sealing member 14, a tube 16, a hub 18, a blood collection needle 20, a cap 22, and the like. . The hub 18 fixes the blood collection needle 20 and is connected to the tube 12. When the cap 22 covers the blood collection needle 20, the tube 12 is sealed. In the present embodiment, the hub 18, the blood collection needle 20 and the cap 22 constitute an example of the “end connection member” of the present invention.
<採血用器具の構成>
図1に示すように、本実施例の採血用器具1は、採血バッグ10と、チューブ12と、封止部材14と、チューブ16と、ハブ18と、採血針20と、キャップ22などを有する。ハブ18は、採血針20を固定するとともにチューブ12と接続する。キャップ22が採血針20を覆うことにより、チューブ12は封止された状態となる。なお、本実施例においては、ハブ18と採血針20とキャップ22により、本発明の「端部接続部材」の一例が構成されている。 [Example 1]
<Configuration of blood collection device>
As shown in FIG. 1, the blood collection instrument 1 of this embodiment includes a
採血バッグ10は、採血された血液を収納するバッグである。この採血バッグ10は、袋状に構成したバッグ本体30を有する。バッグ本体30は、樹脂製の可撓性を有するシート材を重ね、その周縁のシール部32において融着(熱融着、高周波融着等)または接着して形成されている。そして、バッグ本体30のシール部32で囲まれる内側の部分に、採血血液が収納される血液収納部34が形成されている。血液収納部34内には、薬液である液体の上記薬液24が収納(収容)されている。上記薬液24は、例えば、ACD(アシッドサイトレート・デキストロース)、CPD液(サイトレート・フォスフェイト・デキストロース)、MAP液、SAGM液、OPTISOL液等である。なお、上記薬液24の量は、予定採血量に応じて適正な量に調整されている。
The blood collection bag 10 is a bag for storing collected blood. The blood collection bag 10 has a bag body 30 configured in a bag shape. The bag body 30 is formed by stacking resin-made flexible sheet materials and fusing (thermal fusing, high-frequency fusing, etc.) or bonding at the peripheral seal portion 32. A blood storage portion 34 for storing blood sampled blood is formed in an inner portion surrounded by the seal portion 32 of the bag body 30. In the blood storage portion 34, the liquid chemical liquid 24, which is a chemical liquid, is stored (accommodated). Examples of the drug solution 24 include ACD (acid citrate dextrose), CPD solution (cytolate phosphate dextrose), MAP solution, SAGM solution, OPTISOL solution, and the like. The amount of the drug solution 24 is adjusted to an appropriate amount according to the planned blood collection amount.
また、バッグ本体30は、その上部に、排出口36を有する。排出口36は、開封可能に封止されており、2つ設けられている。そして、一方の排出口36の側部に、封止部材14が設けられている。封止部材14は、可撓性を有するチューブ16の一端部に接続している。さらに、バッグ本体30は、可撓性を有するチューブ12の他端部12bに接続している。なお、排出口36やチューブ12や封止部材14の各々の内部は、いずれも血液収納部34に連通している。
Further, the bag body 30 has a discharge port 36 at the top thereof. The discharge port 36 is sealed so that it can be opened, and two discharge ports 36 are provided. A sealing member 14 is provided on the side of one discharge port 36. The sealing member 14 is connected to one end of a tube 16 having flexibility. Furthermore, the bag body 30 is connected to the other end portion 12b of the tube 12 having flexibility. Note that the inside of each of the discharge port 36, the tube 12, and the sealing member 14 communicates with the blood storage portion 34.
チューブ12は、その一端部12aにて、ハブ18を介して採血針20に連通するようにして接続している。また、チューブ12は、その他端部12bにて、採血バッグ10のバッグ本体30に連通するようにして接続している。そして、チューブ12は、筒状に形成されており、その内部に、採血針20により採血された血液を採血バッグ10へ導入するための流路を備えている。そして、チューブ12の内部に、上記薬液24が注入されている。なお、チューブ12は、本発明の「チューブ」の一例である。
The tube 12 is connected to the blood collection needle 20 through the hub 18 at one end 12a. Further, the tube 12 is connected at the other end 12b so as to communicate with the bag body 30 of the blood collection bag 10. The tube 12 is formed in a cylindrical shape, and has a flow path for introducing blood collected by the blood collection needle 20 into the blood collection bag 10 therein. The chemical solution 24 is injected into the tube 12. The tube 12 is an example of the “tube” in the present invention.
また、ハブ18は、チューブ12と採血針20に接続する。そして、ハブ18は、採血針20を覆い包むキャップ22が装着され、キャップ22を外すことにより開封可能となっている。
The hub 18 is connected to the tube 12 and the blood collection needle 20. The hub 18 is fitted with a cap 22 that covers the blood collection needle 20 and can be opened by removing the cap 22.
これらのチューブ12とハブ18と採血針20とキャップ22により、採血ラインが構成される。
These tubes 12, hub 18, blood collection needle 20 and cap 22 constitute a blood collection line.
なお、前記のチューブ16の他端側に、例えば、不図示の血漿バッグ、バフィーコートバッグ、血小板バッグ(薬液貯留バッグ)等の1または2以上のバッグが設けられていてもよい。すなわち、採血用器具1は、バッグ連結体を構成してもよい。
It should be noted that one or more bags such as a plasma bag (not shown), a buffy coat bag, a platelet bag (medicine solution storage bag), and the like may be provided on the other end side of the tube 16. That is, the blood collection instrument 1 may constitute a bag connector.
次に、採血バッグ10を構成するシート材や、チューブ12の構成材料や、チューブ16の構成材料等について説明する。
Next, the sheet material constituting the blood collection bag 10, the constituent material of the tube 12, the constituent material of the tube 16, and the like will be described.
採血バッグ10のバッグ本体30を構成するシート材の組成、特性等は、特に限定されない。この場合、採血バッグ10のシート材の構成材料としては、軟質ポリ塩化ビニルまたは軟質ポリ塩化ビニルを主とする材料(例えば、少量の他の高分子材料との共重合体、ポリマーブレンド、ポリマーアロイ等)が好ましい。この軟質ポリ塩化ビニルにおける可塑剤としては、例えば、フタル酸ジ-2-エチルヘキシル(DEHP)、フタル酸ジノルマルデシル(DnDP)等が好ましい。可塑剤のシート材中の含有量は、25~50wt%程度が好ましく、30~40wt%程度がより好ましい。
The composition, characteristics, etc. of the sheet material constituting the bag body 30 of the blood collection bag 10 are not particularly limited. In this case, the constituent material of the sheet material of the blood collection bag 10 is a material mainly composed of soft polyvinyl chloride or soft polyvinyl chloride (for example, a copolymer with a small amount of other polymer material, a polymer blend, a polymer alloy). Etc.) is preferred. As the plasticizer in the soft polyvinyl chloride, for example, di-2-ethylhexyl phthalate (DEHP), dinormaldecyl phthalate (DnDP) and the like are preferable. The content of the plasticizer in the sheet material is preferably about 25 to 50 wt%, more preferably about 30 to 40 wt%.
以上のようなシート材は、例えば次のような方法で製造することができる。混練機を用いて所定の材料を十分に混練し、該混練物をTダイあるいはサーキュラーダイを介して押し出し、得られた平坦なシート状物等に対し、サーモフォーミング、ブロー、延伸、裁断、端部のシール(融着)等の工程を順次行って、所望の形状・形態に加工する。また、シート間のブロッキングを防ぐためにシート(基材)表面を粗面化(エンボス加工)したり、ブロッキング防止剤、スリップ剤等を添加または付与することもできる。
The sheet material as described above can be manufactured, for example, by the following method. A predetermined material is sufficiently kneaded using a kneader, the kneaded product is extruded through a T die or a circular die, and the obtained flat sheet-like material is subjected to thermoforming, blowing, stretching, cutting, and cutting. Steps such as part sealing (fusion) are sequentially performed to form a desired shape and form. Moreover, in order to prevent blocking between sheets, the surface of a sheet (base material) can be roughened (embossed), or an anti-blocking agent, a slip agent, etc. can be added or applied.
チューブ12やチューブ16の構成材料としては、例えば、軟質ポリ塩化ビニル、ポリエチレン、ポリプロピレン、エチレン-酢酸ビニル共重合体、スチレン-ブタジエン-スチレン共重合体等の熱可塑性エラストマー等、あるいはこれらを主とする材料が挙げられるが、そのなかでも特に、軟質ポリ塩化ビニルまたはこれを主とする材料が好ましい。
Examples of the constituent material of the tube 12 and the tube 16 include thermoplastic elastomers such as soft polyvinyl chloride, polyethylene, polypropylene, ethylene-vinyl acetate copolymer, styrene-butadiene-styrene copolymer, and the like. Among them, soft polyvinyl chloride or a material mainly composed of this is preferable.
各チューブが軟質ポリ塩化ビニル製であれば、十分な可撓性、柔軟性が得られるので取り扱いがし易く、また、クレンメ等による閉塞に適する。さらに、軟質ポリ塩化ビニル製チューブは、主材料を同じくするバッグのシート材との相溶性に優れるので、融着や接着によりこれらを接合する場合に、その接合強度が高く、かつ気密性に優れ、遠心分離操作に対する耐久性や無菌性の維持にとって好ましい。なお、各チューブに用いられる可塑剤の種類やその含有量は特に限定されない。
If each tube is made of soft polyvinyl chloride, sufficient flexibility and softness can be obtained, so that it is easy to handle and suitable for clogging with a clamp or the like. In addition, the tube made of soft polyvinyl chloride is excellent in compatibility with the bag material of the same main material, so when joining them by fusion or adhesion, the joint strength is high and the air tightness is excellent. It is preferable for maintaining durability and sterility against the centrifugation operation. In addition, the kind of plasticizer used for each tube and its content are not specifically limited.
<採血用器具の作用>
次に、採血用器具1の作用として、採血用器具1を用いた血液処理方法について説明する。まず、ハブ18からキャップ22が取り外され、ドナー(供血者)の静脈(血管)に採血針20により穿刺が行われる。これにより、採血された血液は、チューブ12を流れて、採血バッグ10の内部における上記薬液24が注入されている血液収納部34に導入される。このようにして、血液は、採血バッグ10に採取される。 <Operation of blood collection device>
Next, a blood processing method using the blood collection device 1 will be described as an action of the blood collection device 1. First, thecap 22 is removed from the hub 18 and puncture is performed with a blood collection needle 20 into a vein (blood vessel) of a donor (blood donor). Thereby, the collected blood flows through the tube 12 and is introduced into the blood storage part 34 in which the drug solution 24 is injected in the blood collection bag 10. In this way, blood is collected in the blood collection bag 10.
次に、採血用器具1の作用として、採血用器具1を用いた血液処理方法について説明する。まず、ハブ18からキャップ22が取り外され、ドナー(供血者)の静脈(血管)に採血針20により穿刺が行われる。これにより、採血された血液は、チューブ12を流れて、採血バッグ10の内部における上記薬液24が注入されている血液収納部34に導入される。このようにして、血液は、採血バッグ10に採取される。 <Operation of blood collection device>
Next, a blood processing method using the blood collection device 1 will be described as an action of the blood collection device 1. First, the
<チューブの一端部の構成>
次に、チューブ12の一端部12aの構成について説明する。図2に示すように、チューブ12は、その内部に上記薬液24が注入されているが、ハブ18を介して採血針20に接続する一端部12aの内部に、空間であるエア置換部40が形成されている。このエア置換部40は、チューブ12の一端部12aにおける採血針20が接続される側(図2の右側)の先端から他端部12b側(図2の左側)に形成されている。一例として、一端部12aの幅Δは80mmであり、エア置換部40の幅δは10mm~80mmである。なお、幅Δと幅δは、ともに、チューブ12の中心軸方向(図2の左右方向)の幅である。 <Configuration of one end of the tube>
Next, the configuration of the oneend portion 12a of the tube 12 will be described. As shown in FIG. 2, the drug solution 24 is injected into the tube 12, but an air replacement unit 40, which is a space, is provided inside the one end 12 a connected to the blood collection needle 20 via the hub 18. Is formed. The air replacement part 40 is formed from the tip of the end 12a of the tube 12 to which the blood collection needle 20 is connected (right side in FIG. 2) to the other end 12b side (left side in FIG. 2). As an example, the width Δ of the one end portion 12a is 80 mm, and the width δ of the air replacement portion 40 is 10 mm to 80 mm. Both the width Δ and the width δ are widths in the central axis direction of the tube 12 (left and right direction in FIG. 2).
次に、チューブ12の一端部12aの構成について説明する。図2に示すように、チューブ12は、その内部に上記薬液24が注入されているが、ハブ18を介して採血針20に接続する一端部12aの内部に、空間であるエア置換部40が形成されている。このエア置換部40は、チューブ12の一端部12aにおける採血針20が接続される側(図2の右側)の先端から他端部12b側(図2の左側)に形成されている。一例として、一端部12aの幅Δは80mmであり、エア置換部40の幅δは10mm~80mmである。なお、幅Δと幅δは、ともに、チューブ12の中心軸方向(図2の左右方向)の幅である。 <Configuration of one end of the tube>
Next, the configuration of the one
エア置換部40の軸方向の幅δは、10mm~80mmが好ましく、15mm~60mmがさらに好ましい。幅δが前記の範囲の下限値より短いと、チューブ12内の薬液が外部に飛散する可能性が増加し、幅δが前記の範囲の上限値より長いと、製造装置が大きくなってしまう。
The width δ in the axial direction of the air replacement part 40 is preferably 10 mm to 80 mm, and more preferably 15 mm to 60 mm. When the width δ is shorter than the lower limit value of the above range, the possibility that the chemical solution in the tube 12 is scattered outside increases, and when the width δ is longer than the upper limit value of the above range, the manufacturing apparatus becomes large.
このように、チューブ12は、幅Δで規定される一端部12aの領域内において、エア置換部40を備えている。
As described above, the tube 12 includes the air replacement portion 40 in the region of the one end portion 12a defined by the width Δ.
<採血用器具の製造方法>
次に、採血用器具1の製造方法として、採血バッグ10とチューブ12に上記薬液24を注入し、その後、チューブ12に採血針20を接続する方法について説明する。本実施例では、採血用器具1を製造する際に、チャックCH1とチャックCH2とチャックCH3と注入ノズルNが使用される。一例として、チャックCH1における幅L1は7mmとし、チャックCH2における幅L2は7mmとし、チャックCH3における幅L3は2mmとし、注入ノズルNの注入口Naにおける幅LNは5~7mmとする。なお、幅L1と幅L2と幅L3と幅LNは、いずれも、チューブ12の中心軸方向の幅である。 <Method for manufacturing blood sampling device>
Next, a method for injecting thedrug solution 24 into the blood collection bag 10 and the tube 12 and then connecting the blood collection needle 20 to the tube 12 will be described as a method for manufacturing the blood collection instrument 1. In this embodiment, the chuck CH1, the chuck CH2, the chuck CH3, and the injection nozzle N are used when the blood collection instrument 1 is manufactured. As an example, the width L1 of the chuck CH1 is 7 mm, the width L2 of the chuck CH2 is 7 mm, the width L3 of the chuck CH3 is 2 mm, and the width LN of the injection port Na of the injection nozzle N is 5 to 7 mm. The width L1, the width L2, the width L3, and the width LN are all widths in the central axis direction of the tube 12.
次に、採血用器具1の製造方法として、採血バッグ10とチューブ12に上記薬液24を注入し、その後、チューブ12に採血針20を接続する方法について説明する。本実施例では、採血用器具1を製造する際に、チャックCH1とチャックCH2とチャックCH3と注入ノズルNが使用される。一例として、チャックCH1における幅L1は7mmとし、チャックCH2における幅L2は7mmとし、チャックCH3における幅L3は2mmとし、注入ノズルNの注入口Naにおける幅LNは5~7mmとする。なお、幅L1と幅L2と幅L3と幅LNは、いずれも、チューブ12の中心軸方向の幅である。 <Method for manufacturing blood sampling device>
Next, a method for injecting the
なお、チャックCH1とチャックCH2とチャックCH3と注入ノズルNの各々の動作は、不図示の制御部により、自動制御されていてもよい。また、チャックCH1とチャックCH2は本発明の「第1把持具」の一例であり、チャックCH3は本発明の「第2把持具」の一例である。
In addition, each operation | movement of chuck | zipper CH1, chuck | zipper CH2, chuck | zipper CH3, and the injection | pouring nozzle N may be automatically controlled by the control part not shown. Further, the chuck CH1 and the chuck CH2 are examples of the “first gripping tool” of the present invention, and the chuck CH3 is an example of the “second gripping tool” of the present invention.
また、幅L1と幅L2と幅L3の大きさは、前記の数値に特に限定されず、変更可能である。一例として、(L1+L2)-L3=5mm~75mmの条件を満たすようにして、幅L1と幅L2と幅L3の大きさが規定されるとしてもよい。このように、チャックCH3の幅L3は、チャックCH1の幅L1とチャックCH2の幅L2との合計幅よりも小さい。
Further, the sizes of the width L1, the width L2, and the width L3 are not particularly limited to the above numerical values and can be changed. As an example, the width L1, the width L2, and the width L3 may be defined so as to satisfy the condition of (L1 + L2) −L3 = 5 mm to 75 mm. Thus, the width L3 of the chuck CH3 is smaller than the total width of the width L1 of the chuck CH1 and the width L2 of the chuck CH2.
そこで、まず、薬液注入工程が行われる。具体的には、図3に示すように、注入ノズルNの注入口Naが、チューブ12の一端部12aの内部に挿入される。そして、注入ノズルNの注入口Naから、上記薬液24が、チューブ12を介して採血バッグ10の血液収納部34内に注入される。これにより、上記薬液24が、採血バッグ10の内部とチューブ12の内部とに注入される。
Therefore, first, a chemical injection process is performed. Specifically, as shown in FIG. 3, the injection port Na of the injection nozzle N is inserted into the one end portion 12 a of the tube 12. Then, the drug solution 24 is injected into the blood storage part 34 of the blood collection bag 10 through the tube 12 from the injection port Na of the injection nozzle N. As a result, the drug solution 24 is injected into the blood collection bag 10 and the tube 12.
次に、サックバック工程が行われる。具体的には、図4に示すように、チャックCH1とチャックCH2により、チューブ12が当該チューブ12の径方向に押し潰されるように把持される。さらに、チューブ12の一端部12aにて、チューブ12の内部が注入ノズルNを介して減圧吸引される。
Next, a suck back process is performed. Specifically, as shown in FIG. 4, the tube 12 is gripped by the chuck CH <b> 1 and the chuck CH <b> 2 so as to be crushed in the radial direction of the tube 12. Further, the inside of the tube 12 is sucked under reduced pressure through the injection nozzle N at one end 12 a of the tube 12.
次に、ノズル後退工程が行われる。具体的には、図5に示すように、注入ノズルNの注入口Naが、チューブ12の一端部12aの内部から取り外されて後退する。これにより、チューブ12の一端部12aの内部に、空間であるエア置換部40が形成される。エア置換部40は、チューブ12の一端部12aにおける採血針20が接続される側(図5の右側)の先端から他端部12b側(図5の左側)に形成されている。このときのエア置換部40の幅δは、例えば、5mm~7mmである。なお、幅δは、チューブ12の中心軸方向(図5の左右方向)の幅である。
Next, a nozzle retracting process is performed. Specifically, as shown in FIG. 5, the injection port Na of the injection nozzle N is removed from the inside of the one end 12 a of the tube 12 and retreats. Thereby, the air replacement part 40 which is space is formed inside the one end part 12 a of the tube 12. The air replacement section 40 is formed from the tip of the end 12a of the tube 12 to which the blood collection needle 20 is connected (right side in FIG. 5) to the other end 12b side (left side in FIG. 5). At this time, the width δ of the air replacement section 40 is, for example, 5 mm to 7 mm. The width δ is the width of the tube 12 in the central axis direction (left-right direction in FIG. 5).
次に、チャック掴み替え工程が行われる。具体的には、図6に示すように、チューブ12がチャックCH1とチャックCH2により把持される状態から開放される一方で、チャックCH3によりチューブ12が当該チューブ12の径方向に押し潰されるように把持される。ここで、チューブ12がチャックCH1とチャックCH2により把持される状態から開放されるタイミングは、チューブ12がチャックCH3により把持されるタイミングと同時、あるいは、チューブ12がチャックCH3により把持されるタイミングよりも後である。
Next, a chuck grip replacement process is performed. Specifically, as shown in FIG. 6, while the tube 12 is released from the state of being gripped by the chuck CH1 and the chuck CH2, the tube 12 is crushed in the radial direction of the tube 12 by the chuck CH3. Grasped. Here, the timing at which the tube 12 is released from the state of being gripped by the chuck CH1 and the chuck CH2 is the same as the timing at which the tube 12 is gripped by the chuck CH3, or the timing at which the tube 12 is gripped by the chuck CH3. Later.
そして、このようなチャック掴み替え工程が行われることにより、エア置換部40の幅が拡がる。例えば、チャック掴み替え工程が終了したときに、エア置換部40の幅δは、10mm~80mmである。ここで、比較例として、チャック掴み替え工程が行われない場合には、エア置換部40の幅δは、10mm未満となってしまう。このように、チャック掴み替え工程が行われることにより、チャック掴み替え工程が行われない場合よりも、エア置換部40の幅δを大きくすることができる。
And the width | variety of the air replacement part 40 expands by performing such a chuck holding | grip replacement process. For example, the width δ of the air replacement unit 40 is 10 mm to 80 mm when the chuck grip replacement process is completed. Here, as a comparative example, when the chuck holding step is not performed, the width δ of the air replacement unit 40 is less than 10 mm. Thus, the width δ of the air replacement unit 40 can be increased by performing the chuck re-holding step as compared to the case where the chuck re-holding step is not performed.
次に、採血針接続工程が行われる。具体的には、図7に示すように、チャックCH3によりチューブ12が把持されながら、チューブ12の一端部12aに、ハブ18を介して、キャップ22が接続された採血針20が接続される。これにより、前記の図2に示すように、採血針20とキャップ22が、ハブ18を介して、チューブ12の一端部12aに接続される。なお、採血針接続工程は、本発明の「端部接続部材接続工程」の一例である。
Next, a blood collection needle connecting step is performed. Specifically, as shown in FIG. 7, while the tube 12 is gripped by the chuck CH3, the blood collection needle 20 to which the cap 22 is connected is connected to the one end portion 12a of the tube 12 via the hub 18. Thereby, as shown in FIG. 2, the blood collection needle 20 and the cap 22 are connected to the one end portion 12 a of the tube 12 through the hub 18. The blood collection needle connecting step is an example of the “end connecting member connecting step” in the present invention.
以上のようにして、採血バッグ10とチューブ12に上記薬液24を注入し、その後、チューブ12に採血針20を接続することができる。そして、その後、チューブ12がチャックCH3により把持される状態から開放されることにより、チューブ12の一端部12aの構成は、前記の図2に示すようになる。このとき、エア置換部40の幅δは10mm~80mmである。
As described above, the drug solution 24 is injected into the blood collection bag 10 and the tube 12, and then the blood collection needle 20 can be connected to the tube 12. Then, after that, the tube 12 is released from the state of being gripped by the chuck CH3, whereby the configuration of the one end portion 12a of the tube 12 is as shown in FIG. At this time, the width δ of the air replacement part 40 is 10 mm to 80 mm.
なお、図8に示すように、変形例として、前記のようにチャックCH1とチャックCH2が使用される代わりに、1つのチャックCHXが使用されるとしてもよい。このとき、チャックCHXにおけるチューブ12の中心軸方向の幅LXは、チャックCH1の幅L1とチャックCH2の幅L2の合計幅と同じである。一例として、チャックCHXの幅LXは、14mmである。なお、チャックCHXは、本発明の「第1把持具」の一例である。
As shown in FIG. 8, as a modification, instead of using the chuck CH1 and the chuck CH2 as described above, one chuck CHX may be used. At this time, the width LX in the central axis direction of the tube 12 in the chuck CHX is the same as the total width of the width L1 of the chuck CH1 and the width L2 of the chuck CH2. As an example, the width LX of the chuck CHX is 14 mm. The chuck CHX is an example of the “first gripper” in the present invention.
本実施例の採血用器具1は、チューブ12の一端部12aの内部にエア置換部40が形成され、エア置換部40の幅δは10mm~80mmである。このように、チューブ12の一端部12aの内部にエア置換部40が十分に形成されている。そのため、採血用器具1の製造時にチューブ12の一端部12aにハブ18を介して採血針20が接続されるときに、作業者が誤ってチューブ12を押し潰しても、チューブ12の内部に注入されている上記薬液24がチューブ12から漏れ出て採血用器具1の外面に付着するおそれがない。したがって、採血用器具1の製造時にて、外観不良などの不具合が発生することを防止できる。ゆえに、採血用器具1の製品の歩留まりが向上する。
In the blood collection device 1 of the present embodiment, the air replacement part 40 is formed inside the one end part 12a of the tube 12, and the width δ of the air replacement part 40 is 10 mm to 80 mm. As described above, the air replacement portion 40 is sufficiently formed inside the one end portion 12 a of the tube 12. Therefore, when the blood collection needle 20 is connected to the one end portion 12a of the tube 12 via the hub 18 when the blood collection device 1 is manufactured, even if the operator accidentally crushes the tube 12, it is injected into the tube 12. There is no possibility that the drug solution 24 leaked from the tube 12 and adheres to the outer surface of the blood sampling device 1. Therefore, it is possible to prevent the occurrence of problems such as poor appearance when the blood collecting instrument 1 is manufactured. Therefore, the product yield of the blood collection instrument 1 is improved.
また、採血用器具1における端部接続部材は、採血針20と、チューブ12と採血針20とを接続するハブ18と、キャップ22を備えている。このように、採血バッグ10に接続するチューブ12に直接的にハブ18と採血針20とが接続している採血用器具1の製造時にて、外観不良などの不具合が発生することを防止できる。
Further, the end connection member in the blood collection instrument 1 includes a blood collection needle 20, a hub 18 that connects the tube 12 and the blood collection needle 20, and a cap 22. In this way, it is possible to prevent problems such as poor appearance during the production of the blood collection instrument 1 in which the hub 18 and the blood collection needle 20 are directly connected to the tube 12 connected to the blood collection bag 10.
本実施例の採血用器具1の製造方法は、薬液注入工程と、サックバック工程と、ノズル後退工程と、チャック掴み替え工程と、採血針接続工程と、が行われ、チャック掴み替え工程が終了したときに、エア置換部40の幅δは10mm~80mmである。このように、チャック掴み替え工程が終了したときに、チューブ12の一端部12aの内部にエア置換部40が十分に形成されている。そのため、採血針接続工程が行われるときに、作業者が誤ってチューブ12を押し潰しても、チューブ12の内部に注入されている上記薬液24がチューブ12から漏れ出て採血用器具1の外面に付着するおそれがない。そのため、採血用器具1の製造時にて、外観不良などの不具合が発生することを防止できる。したがって、採血用器具1の製品の歩留まりが向上する。
In the method of manufacturing the blood sampling instrument 1 of the present embodiment, a chemical solution injection process, a suck back process, a nozzle retraction process, a chuck grip replacement process, and a blood sampling needle connection process are performed, and the chuck grip replacement process ends. In this case, the width δ of the air replacement part 40 is 10 mm to 80 mm. As described above, when the chuck gripping replacement process is completed, the air replacement portion 40 is sufficiently formed inside the one end portion 12 a of the tube 12. Therefore, even if the operator accidentally crushes the tube 12 when the blood collection needle connecting step is performed, the drug solution 24 injected into the tube 12 leaks from the tube 12 and the outer surface of the blood collection device 1. There is no risk of sticking to. Therefore, it is possible to prevent the occurrence of problems such as poor appearance when the blood collecting instrument 1 is manufactured. Therefore, the product yield of the blood collection instrument 1 is improved.
また、チャック掴み替え工程では、チューブ12がチャックCH1とチャックCH2により把持される状態から開放されるタイミングは、チューブ12がチャックCH3により把持されるタイミングと同時、または、チューブ12がチャックCH3により把持されるタイミングよりも後である。これにより、チャック掴み替え工程において、チューブ12の内部に注入されている上記薬液24がチューブ12から漏れ出ることなく、確実に、チャックCH1とチャックCH2からチャックCH3への掴み替え、または、チャックCHXからチャックCH3への掴み替えを行うことができる。
Further, in the chuck grip changing step, the timing at which the tube 12 is released from the state of being gripped by the chuck CH1 and the chuck CH2 is the same as the timing at which the tube 12 is gripped by the chuck CH3, or the tube 12 is gripped by the chuck CH3. Later than the timing. Thereby, in the chuck re-holding step, the chemical liquid 24 injected into the tube 12 does not leak from the tube 12, and the chuck CH1 and the chuck CH2 are reliably re-gripped to the chuck CH3, or the chuck CHX. To the chuck CH3.
また、(LH1-LH2)-LH3=5mm~75mmである。これにより、チャック掴み替え工程において、より効果的に、チューブ12の内部のエア置換部40の幅δが拡がる。
Also, (LH1-LH2) −LH3 = 5 mm to 75 mm. As a result, the width δ of the air replacement portion 40 inside the tube 12 is more effectively expanded in the chuck re-holding step.
〔実施例2〕
次に、実施例2について説明するが、実施例1と同等の構成要素については、同一の符号を付して説明を省略し、異なった点を中心に述べる。 [Example 2]
Next, the second embodiment will be described. The same components as those of the first embodiment are denoted by the same reference numerals, the description thereof will be omitted, and different points will be mainly described.
次に、実施例2について説明するが、実施例1と同等の構成要素については、同一の符号を付して説明を省略し、異なった点を中心に述べる。 [Example 2]
Next, the second embodiment will be described. The same components as those of the first embodiment are denoted by the same reference numerals, the description thereof will be omitted, and different points will be mainly described.
<採血用器具の構成>
図9に示すように、実施例2の採血用器具2は、実施例1の採血用器具1と異なる点として、封止部材50と、分岐コネクタ52と、チューブ54と、チューブ56と、クレンメ58と、一時収納バッグ60と、チューブ62と、サンプリングポート64などを有する。そして、採血用器具2は、チューブ12の一端部12aに封止部材50が接続されている。 <Configuration of blood collection device>
As shown in FIG. 9, theblood collection device 2 of Example 2 is different from the blood collection device 1 of Example 1 in that the sealing member 50, the branch connector 52, the tube 54, the tube 56, and the clamp 58, a temporary storage bag 60, a tube 62, a sampling port 64, and the like. In the blood sampling instrument 2, the sealing member 50 is connected to the one end 12 a of the tube 12.
図9に示すように、実施例2の採血用器具2は、実施例1の採血用器具1と異なる点として、封止部材50と、分岐コネクタ52と、チューブ54と、チューブ56と、クレンメ58と、一時収納バッグ60と、チューブ62と、サンプリングポート64などを有する。そして、採血用器具2は、チューブ12の一端部12aに封止部材50が接続されている。 <Configuration of blood collection device>
As shown in FIG. 9, the
なお、本実施例において、封止部材50と、分岐コネクタ52と、チューブ54と、ハブ18と、採血針20と、キャップ22と、チューブ56と、クレンメ58と、一時収納バッグ60と、チューブ62と、サンプリングポート64により、本発明の「端部接続部材」の一例が構成されている。
In this embodiment, the sealing member 50, the branch connector 52, the tube 54, the hub 18, the blood collection needle 20, the cap 22, the tube 56, the clamp 58, the temporary storage bag 60, and the tube 62 and the sampling port 64 constitute an example of the “end connection member” of the present invention.
封止部材50は、チューブ12に開封可能に接続している。この封止部材50は、図10に示すような構造をしており、チューブ12とチューブ54との間を遮断および連通させることができる。
The sealing member 50 is connected to the tube 12 so that it can be opened. The sealing member 50 has a structure as shown in FIG. 10, and can block and communicate between the tube 12 and the tube 54.
図10に示すように、封止部材50は、短チューブ70と筒体72を備えている。短チューブ70は、例えば軟質ポリ塩化ビニルのような可撓性を有する樹脂により構成されている。筒体72は、その一端にて、中実柱状部74により閉塞されている。
As shown in FIG. 10, the sealing member 50 includes a short tube 70 and a cylindrical body 72. The short tube 70 is made of a flexible resin such as soft polyvinyl chloride. The cylindrical body 72 is closed at one end by a solid columnar portion 74.
短チューブ70における図10の左側の端部には、チューブ12の一端部12aが接続されている。また、短チューブ70における図10の右側の端部には、チューブ54が接続されている。なお、図10に示す状態では、チューブ12とチューブ54との間は、筒体72により、遮断されている。
One end portion 12a of the tube 12 is connected to the left end portion of the short tube 70 in FIG. Further, the tube 54 is connected to the right end of the short tube 70 in FIG. In the state shown in FIG. 10, the tube 12 and the tube 54 are blocked by the cylindrical body 72.
筒体72の外周には、薄肉で脆弱な破断部76が形成されている。そして、手指等によって短チューブ70の外部から短チューブ70ごと中実柱状部74が折り曲げられることにより破断部76が破断すると、筒体72から中実柱状部74が分離される。これにより、チューブ12とチューブ54との間は、連通する。
A thin and fragile fracture portion 76 is formed on the outer periphery of the cylindrical body 72. When the broken column 76 is broken by folding the solid columnar portion 74 together with the short tube 70 from the outside of the short tube 70 with fingers or the like, the solid columnar portion 74 is separated from the cylindrical body 72. As a result, the tube 12 and the tube 54 communicate with each other.
図9の説明に戻って、分岐コネクタ52は、チューブ54とチューブ56が接続されている。チューブ54は、その一端部にて、ハブ18を介して採血針20に接続している。また、チューブ54は、その他端部にて、封止部材50に接続している。なお、チューブ54は、本発明の「第1チューブ」の一例である。ハブ18は、チューブ54と採血針20とを接続している。また、チューブ54は、その一端部にて、赤血球保存液入りのバッグなどの各種バッグに接続していてもよい。
Returning to the description of FIG. 9, the branch connector 52 is connected to a tube 54 and a tube 56. The tube 54 is connected to the blood collection needle 20 through the hub 18 at one end thereof. The tube 54 is connected to the sealing member 50 at the other end. The tube 54 is an example of the “first tube” in the present invention. The hub 18 connects the tube 54 and the blood collection needle 20. Further, the tube 54 may be connected at one end thereof to various bags such as a bag containing a red blood cell storage solution.
チューブ56は、その一端部における分岐コネクタ52の部分にて、チューブ54から分岐している。そして、チューブ56は、その他端部にて、クレンメ58を介して一時収納バッグ60に接続している。なお、チューブ56は、本発明の「第2チューブ」の一例である。
The tube 56 branches off from the tube 54 at the branch connector 52 portion at one end thereof. The tube 56 is connected to the temporary storage bag 60 via the clamp 58 at the other end. The tube 56 is an example of the “second tube” in the present invention.
一時収納バッグ60は、チューブ56の他端部に接続し、採血された血液を一時的に収納するバッグである。この一時収納バッグ60は、例えば、後述するポリ塩化ビニルのような軟質樹脂製の可撓性を有するシート材を重ね、その周縁のシール部80において、融着(熱融着、高周波融着等)または接着し、袋状としたバッグ本体82を有している。
The temporary storage bag 60 is a bag that is connected to the other end of the tube 56 and temporarily stores the collected blood. This temporary storage bag 60 is made of, for example, a flexible sheet material made of a soft resin such as polyvinyl chloride, which will be described later, and is fused (heat fusion, high frequency fusion, etc.) at the peripheral seal portion 80. Or a bag body 82 which is bonded to form a bag.
チューブ62は、その一端に一時収納バッグ60が接続され、その他端にサンプリングポート(コネクタ)64が接続されている。このサンプリングポート64には、例えば、不図示の減圧採血管(容器)のホルダー(減圧採血管用採血器具)が接続され、このホルダーと減圧採血管とにより、血液の初流(採血初流)が減圧採血管に回収される。
The tube 62 has a temporary storage bag 60 connected to one end and a sampling port (connector) 64 connected to the other end. The sampling port 64 is connected to, for example, a holder of a decompression blood collection tube (container) (not illustrated) (a blood collection device for decompression blood collection tube). Collected in a vacuum blood collection tube.
<採血用器具の作用>
次に、採血用器具2の作用として、採血用器具2を用いた血液処理方法について説明する。 <Operation of blood collection device>
Next, a blood processing method using theblood collection device 2 will be described as an action of the blood collection device 2.
次に、採血用器具2の作用として、採血用器具2を用いた血液処理方法について説明する。 <Operation of blood collection device>
Next, a blood processing method using the
まず、ハブ18からキャップ22が取り外され、ドナー(供血者)の静脈(血管)に採血針20により穿刺が行われる。このとき、チューブ12とチューブ54との間は、封止部材50により遮断されているので、血液は、チューブ54から分岐コネクタ52を経てチューブ56に流れ込む。これにより、採血初流(血液)は、採血針20、チューブ54、分岐コネクタ52を経て、チューブ56へ流入して、一時収納バッグ60の内部に導入される。このようにして、血液が一時収納バッグ60に所定量採血(採取)された後、クレンメ58によりチューブ56が閉められ、チューブ56の流路が閉塞する(遮断される)。
First, the cap 22 is removed from the hub 18 and puncture is performed with a blood collection needle 20 into a vein (blood vessel) of a donor (blood donor). At this time, since the space between the tube 12 and the tube 54 is blocked by the sealing member 50, blood flows from the tube 54 to the tube 56 through the branch connector 52. Thereby, the initial blood flow (blood) flows through the blood collection needle 20, the tube 54, and the branch connector 52, flows into the tube 56, and is introduced into the temporary storage bag 60. Thus, after a predetermined amount of blood is collected (collected) in the temporary storage bag 60, the tube 56 is closed by the clamp 58, and the flow path of the tube 56 is closed (blocked).
次に、前記のように短チューブ70の外部から短チューブ70ごと中実柱状部74が折り曲げられることにより封止部材50の破断部76が破断すると、チューブ12とチューブ54との間が連通する。これにより、採血された血液は、チューブ54とチューブ12を流れて、採血バッグ10の血液収納部34に導入される。このようにして、血液は、採血バッグ10に採取される。
Next, when the broken portion 76 of the sealing member 50 is broken by bending the solid columnar portion 74 together with the short tube 70 from the outside of the short tube 70 as described above, the tube 12 and the tube 54 communicate with each other. . Thereby, the collected blood flows through the tube 54 and the tube 12 and is introduced into the blood storage part 34 of the blood collection bag 10. In this way, blood is collected in the blood collection bag 10.
<チューブの一端部の構成>
次に、チューブ12の一端部12aの構成について説明する。図10に示すように、チューブ12は、その内部に上記薬液24が注入されているが、封止部材50に接続する一端部12aの内部に、空間であるエア置換部40が形成されている。例えば、一端部12aの幅Δは80mmであり、エア置換部40の幅δは10mm~80mmである。 <Configuration of one end of the tube>
Next, the configuration of the oneend portion 12a of the tube 12 will be described. As shown in FIG. 10, the chemical liquid 24 is injected into the tube 12, but an air replacement portion 40 that is a space is formed inside the one end portion 12 a connected to the sealing member 50. . For example, the width Δ of the one end portion 12a is 80 mm, and the width δ of the air replacement portion 40 is 10 mm to 80 mm.
次に、チューブ12の一端部12aの構成について説明する。図10に示すように、チューブ12は、その内部に上記薬液24が注入されているが、封止部材50に接続する一端部12aの内部に、空間であるエア置換部40が形成されている。例えば、一端部12aの幅Δは80mmであり、エア置換部40の幅δは10mm~80mmである。 <Configuration of one end of the tube>
Next, the configuration of the one
<採血用器具の製造方法>
本実施例では、実施例1と異なる点として、採血針接続工程の代わりに、封止部材接続工程が行われる。具体的には、図11に示すように、チャックCH3によりチューブ12が把持されながら、チューブ12の一端部12aに、封止部材50が接続される。これにより、前記の図9に示すように、採血針20と一時収納バッグ60が、封止部材50を介して、チューブ12の一端部12aに接続される。なお、封止部材接続工程は、本発明の「端部接続部材接続工程」の一例である。 <Method for manufacturing blood sampling device>
In the present embodiment, as a difference from the first embodiment, a sealing member connecting step is performed instead of the blood collection needle connecting step. Specifically, as shown in FIG. 11, the sealingmember 50 is connected to the one end portion 12a of the tube 12 while the tube 12 is gripped by the chuck CH3. Thereby, as shown in FIG. 9, the blood collection needle 20 and the temporary storage bag 60 are connected to the one end portion 12 a of the tube 12 via the sealing member 50. The sealing member connecting step is an example of the “end connecting member connecting step” in the present invention.
本実施例では、実施例1と異なる点として、採血針接続工程の代わりに、封止部材接続工程が行われる。具体的には、図11に示すように、チャックCH3によりチューブ12が把持されながら、チューブ12の一端部12aに、封止部材50が接続される。これにより、前記の図9に示すように、採血針20と一時収納バッグ60が、封止部材50を介して、チューブ12の一端部12aに接続される。なお、封止部材接続工程は、本発明の「端部接続部材接続工程」の一例である。 <Method for manufacturing blood sampling device>
In the present embodiment, as a difference from the first embodiment, a sealing member connecting step is performed instead of the blood collection needle connecting step. Specifically, as shown in FIG. 11, the sealing
ここで、前記のように、採血バッグ10とチューブ12に上記薬液24を注入し、その後、チューブ12に採血針20を接続して製造した採血用器具1と採血用器具2について、滅菌後、外観不良の発生について評価を行った。すると、採血用器具1について200セットの評価を行い、採血用器具2について100セットの評価を行ったが、いずれも、外観不良の発生はなかった。
Here, as described above, the blood collecting device 1 and the blood collecting device 2 manufactured by injecting the drug solution 24 into the blood collecting bag 10 and the tube 12 and then connecting the blood collecting needle 20 to the tube 12 are sterilized, The occurrence of appearance defects was evaluated. Then, 200 sets of evaluations were performed on the blood sampling device 1 and 100 sets of evaluations were performed on the blood sampling device 2, but no appearance defects occurred.
本実施例の採血用器具2は、チューブ12の一端部12aの内部にエア置換部40が形成され、エア置換部40の幅δは10mm~80mmである。このように、チューブ12の一端部12aの内部にエア置換部40が十分に形成されている。そのため、採血用器具2の製造時にチューブ12の一端部12aに封止部材50を接続するときに、作業者が誤ってチューブ12を押し潰しても、チューブ12の内部に注入されている上記薬液24がチューブ12から漏れ出て採血用器具2の外面に付着するおそれがない。したがって、採血用器具2の製造時にて、外観不良などの不具合が発生することを防止できる。ゆえに、採血用器具2の製品の歩留まりが向上する。
In the blood sampling device 2 of the present embodiment, the air replacement part 40 is formed inside the one end part 12a of the tube 12, and the width δ of the air replacement part 40 is 10 mm to 80 mm. As described above, the air replacement portion 40 is sufficiently formed inside the one end portion 12 a of the tube 12. Therefore, when the sealing member 50 is connected to the one end portion 12a of the tube 12 at the time of manufacturing the blood collection device 2, the drug solution injected into the tube 12 even if the operator accidentally crushes the tube 12 There is no fear that 24 leaks out of the tube 12 and adheres to the outer surface of the blood collection device 2. Therefore, it is possible to prevent the occurrence of problems such as poor appearance when the blood collecting instrument 2 is manufactured. Therefore, the product yield of the blood sampling device 2 is improved.
また、採血用器具2の端部接続部材は、チューブ12に接続する封止部材50と、封止部材50に接続するチューブ54と、を備え、封止部材50は、チューブ12とチューブ54との間を遮断および連通させることができる。このように、封止部材50を介して、チューブ12の一端部12aを種々の部材と接続することができ、種々の構成の採血用器具2の製造時にて、外観不良などの不具合が発生することを防止できる。
Further, the end connection member of the blood sampling instrument 2 includes a sealing member 50 connected to the tube 12 and a tube 54 connected to the sealing member 50, and the sealing member 50 includes the tube 12 and the tube 54. Can be blocked and communicated with each other. In this way, the one end portion 12a of the tube 12 can be connected to various members via the sealing member 50, and problems such as poor appearance occur at the time of manufacturing the blood sampling device 2 having various configurations. Can be prevented.
本実施例の採血用器具2の製造方法は、薬液注入工程と、サックバック工程と、ノズル後退工程と、チャック掴み替え工程と、封止部材接続工程と、が行われ、チャック掴み替え工程が終了したときに、エア置換部40の幅δは10mm~80mmである。このように、チャック掴み替え工程が終了したときに、チューブ12の一端部12aの内部にエア置換部40が十分に形成されている。そのため、封止部材接続工程が行われるときに、作業者が誤ってチューブ12を押し潰しても、チューブ12の内部に注入されている上記薬液24がチューブ12から漏れ出て採血用器具2の外面に付着するおそれがない。そのため、採血用器具2の製造時にて、外観不良などの不具合が発生することを防止できる。したがって、採血用器具2の製品の歩留まりが向上する。
The manufacturing method of the blood sampling instrument 2 of the present embodiment includes a chemical solution injection process, a suck back process, a nozzle retraction process, a chuck grip replacement process, and a sealing member connection process. When finished, the width δ of the air replacement part 40 is between 10 mm and 80 mm. As described above, when the chuck gripping replacement process is completed, the air replacement portion 40 is sufficiently formed inside the one end portion 12 a of the tube 12. Therefore, even if an operator accidentally crushes the tube 12 when the sealing member connecting step is performed, the drug solution 24 injected into the tube 12 leaks out of the tube 12 and the blood collecting instrument 2 There is no risk of adhering to the outer surface. Therefore, it is possible to prevent problems such as poor appearance during the production of the blood sampling device 2. Therefore, the product yield of the blood sampling device 2 is improved.
なお、上記した実施の形態は単なる例示にすぎず、本発明を何ら限定するものではなく、その要旨を逸脱しない範囲内で種々の改良、変形が可能であることはもちろんである。
It should be noted that the above-described embodiment is merely an example, and does not limit the present invention in any way, and various improvements and modifications can be made without departing from the scope of the invention.
1 採血用器具
2 採血用器具
10 採血バッグ
12 チューブ
12a 一端部
18 ハブ
20 採血針
22 キャップ
24 上記薬液
40 エア置換部
50 封止部材
60 一時収納バッグ
CH1 チャック
CH2 チャック
CH3 チャック
CHX チャック
N 注入ノズル
Na 注入口
Δ (一端部の)幅
δ (エア置換部の)幅
L1 (チャックCH1の)幅
L2 (チャックCH2の)幅
L3 (チャックCH3の)幅
LX (チャックCHXの)幅
LN (注入ノズルの先端部の)幅 DESCRIPTION OF SYMBOLS 1Blood collection instrument 2 Blood collection instrument 10 Blood collection bag 12 Tube 12a One end part 18 Hub 20 Blood collection needle 22 Cap 24 The said chemical | medical solution 40 Air replacement part 50 Sealing member 60 Temporary storage bag CH1 Chuck CH2 Chuck CH3 Chuck CHX Chuck N Injection nozzle Na Inlet Δ (Width of one end) δ (Air replacement portion) Width L1 (Chuck CH1) Width L2 (Chuck CH2) Width L3 (Chuck CH3) Width LX (Chuck CHX) Width LN (Injection nozzle) Width of tip
2 採血用器具
10 採血バッグ
12 チューブ
12a 一端部
18 ハブ
20 採血針
22 キャップ
24 上記薬液
40 エア置換部
50 封止部材
60 一時収納バッグ
CH1 チャック
CH2 チャック
CH3 チャック
CHX チャック
N 注入ノズル
Na 注入口
Δ (一端部の)幅
δ (エア置換部の)幅
L1 (チャックCH1の)幅
L2 (チャックCH2の)幅
L3 (チャックCH3の)幅
LX (チャックCHXの)幅
LN (注入ノズルの先端部の)幅 DESCRIPTION OF SYMBOLS 1
Claims (9)
- 採取された血液を収納する採血バッグと、一端部が開封可能に封止する端部接続部材に接続し、かつ、他端部が前記採血バッグに接続するチューブと、を有し、薬液を前記採血バッグの内部と前記チューブの内部とに有する採血用器具において、
前記チューブの一端部の内部に空間が形成され、
前記空間の前記チューブの中心軸方向の幅は10mm~80mmであること、
を特徴とする採血用器具。 A blood collection bag for storing the collected blood, a tube connected to an end connection member whose one end is sealed so as to be openable, and a tube connected to the blood collection bag at the other end. In a blood collection instrument having the inside of the blood collection bag and the inside of the tube,
A space is formed inside one end of the tube,
The width of the space in the central axis direction of the tube is 10 mm to 80 mm;
A blood sampling device characterized by - 請求項1の採血用器具において、
前記端部接続部材は、採血針と、前記チューブと前記採血針とを接続するハブと、を備えていること、
を特徴とする採血用器具。 The blood collection device of claim 1,
The end connection member includes a blood collection needle, and a hub for connecting the tube and the blood collection needle;
A blood sampling device characterized by - 請求項1の採血用器具において、
前記端部接続部材は、前記チューブに接続する封止部材と、前記封止部材に接続する第1チューブと、を備え、
前記封止部材は、前記チューブと前記第1チューブとの間を遮断および連通させることができること、
を特徴とする採血用器具。 The blood collection device of claim 1,
The end connection member includes a sealing member connected to the tube, and a first tube connected to the sealing member,
The sealing member is capable of blocking and communicating between the tube and the first tube;
A blood sampling device characterized by - 採取された血液を収納する採血バッグと、一端部が開封可能に封止する端部接続部材に接続し、かつ、他端部が前記採血バッグに接続するチューブと、を有し、薬液を前記採血バッグの内部と前記チューブの内部とに有する採血用器具の製造方法において、
前記チューブの一端部に挿入された注入ノズルから前記薬液が前記採血バッグの内部と前記チューブの内部とに注入される薬液注入工程と、
第1把持具により前記チューブが当該チューブの径方向に押し潰されるように把持されながら、前記チューブの一端部にて前記チューブの内部が減圧吸引されるサックバック工程と、
前記注入ノズルが前記チューブの一端部から後退することにより、前記チューブの一端部の内部に空間が形成されるノズル後退工程と、
前記チューブが前記第1把持具により把持される状態から開放される一方で、前記チューブの中心軸方向の幅が前記第1把持具における前記チューブの中心軸方向の幅よりも小さい第2把持具により前記チューブが当該チューブの径方向に押し潰されるように把持されることにより、前記空間における前記チューブの中心軸方向の幅が拡がるチャック掴み替え工程と、
前記第2把持具により前記チューブが把持されながら、前記チューブの一端部に前記端部接続部材が接続される端部接続部材接続工程と、を有すること、
を特徴とする採血用器具の製造方法。 A blood collection bag for storing the collected blood, a tube connected to an end connection member whose one end is sealed so as to be openable, and a tube connected to the blood collection bag at the other end. In the method for producing a blood collection device having the inside of the blood collection bag and the inside of the tube,
A chemical solution injection step in which the chemical solution is injected into the blood collection bag and the tube from an injection nozzle inserted into one end of the tube;
A suckback step in which the inside of the tube is sucked under reduced pressure at one end of the tube while the tube is gripped by the first gripping tool so as to be crushed in the radial direction of the tube;
A nozzle retreating step in which a space is formed inside one end of the tube by retreating the injection nozzle from one end of the tube;
The second gripping tool is released from the state in which the tube is gripped by the first gripping tool, and the width in the central axis direction of the tube is smaller than the width in the central axis direction of the tube in the first gripping tool. The chuck is replaced so that the tube is crushed in the radial direction of the tube so that the width in the central axis direction of the tube in the space increases, and
An end connection member connecting step in which the end connection member is connected to one end of the tube while the tube is gripped by the second gripping tool,
A method for producing a blood sampling device characterized by the above. - 請求項4の採血用器具の製造方法において、
前記チャック掴み替え工程が終了したときに、前記空間の前記幅は10mm~80mmであること、
を特徴とする採血用器具の製造方法。 In the manufacturing method of the instrument for blood collection of Claim 4,
The width of the space is 10 mm to 80 mm when the chuck re-holding process is completed;
A method for producing a blood sampling device characterized by the above. - 請求項4または5の採血用器具の製造方法において、
前記チャック掴み替え工程では、前記チューブが前記第1把持具により把持される状態から開放されるタイミングは、前記チューブが前記第2把持具により把持されるタイミングと同時、または、前記チューブが前記第2把持具により把持されるタイミングよりも後であること、
を特徴とする採血用器具の製造方法。 In the manufacturing method of the blood collection instrument of Claim 4 or 5,
In the chuck grip changing step, the timing at which the tube is released from the state of being gripped by the first gripping tool is the same as the timing at which the tube is gripped by the second gripping tool, or the tube is 2 Be later than the timing of gripping by the gripping tool,
A method for producing a blood sampling device characterized by the above. - 請求項4乃至6のいずれか1つの採血用器具の製造方法において、
(前記第1把持具における前記チューブの中心軸方向の幅)-(前記第2把持具における前記チューブの中心軸方向の幅)=5mm~75mmであること、
を特徴とする採血用器具の製造方法。 In the manufacturing method of the blood collection instrument according to any one of claims 4 to 6,
(Width in the central axis direction of the tube in the first gripping tool) − (width in the central axis direction of the tube in the second gripping tool) = 5 mm to 75 mm,
A method for producing a blood sampling device characterized by the above. - 請求項4乃至7のいずれか1つの採血用器具の製造方法において、
前記端部接続部材は、採血針と、前記チューブと前記採血針とを接続するハブと、を備えていること、
を特徴とする採血用器具の製造方法。 In the manufacturing method of the blood collection instrument any one of Claims 4 thru | or 7,
The end connection member includes a blood collection needle, and a hub for connecting the tube and the blood collection needle;
A method for producing a blood sampling device characterized by the above. - 請求項4乃至7のいずれか1つの採血用器具の製造方法において、
前記端部接続部材は、前記チューブに接続する封止部材と、前記封止部材に接続する第1チューブと、を備え、
前記封止部材は、前記チューブと前記第1チューブとの間を遮断および連通させることができること、
を特徴とする採血用器具の製造方法。 In the manufacturing method of the blood collection instrument any one of Claims 4 thru | or 7,
The end connection member includes a sealing member connected to the tube, and a first tube connected to the sealing member,
The sealing member is capable of blocking and communicating between the tube and the first tube;
A method for producing a blood sampling device characterized by the above.
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CN201580014363.3A CN106102689B (en) | 2014-03-18 | 2015-02-26 | Blood sampling utensil and the blood sampling manufacturing method of utensil |
JP2016508632A JP6377133B2 (en) | 2014-03-18 | 2015-02-26 | Blood collection device and method for producing blood collection device |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH06261889A (en) * | 1993-03-12 | 1994-09-20 | Nissho Corp | Method for packaging blood taking tube made of synthetic resin containing liquid drug |
JP2001017539A (en) * | 1999-07-09 | 2001-01-23 | Terumo Corp | Blood collecting device |
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US6592613B1 (en) * | 1998-01-16 | 2003-07-15 | Terumo Kabushiki Kaisha | Blood collecting apparatus and blood collecting method using blood collecting apparatus |
JP2004089495A (en) * | 2002-08-30 | 2004-03-25 | Terumo Corp | Bag link |
CN102115456B (en) * | 2009-12-30 | 2014-08-20 | 深圳迈瑞生物医疗电子股份有限公司 | Cyanine compound, composition containing same and application in cell detection thereof |
CN203169191U (en) * | 2012-10-18 | 2013-09-04 | 付士明 | Vacuum blood collection tube for diabetes active peptide blood sample detection |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH06261889A (en) * | 1993-03-12 | 1994-09-20 | Nissho Corp | Method for packaging blood taking tube made of synthetic resin containing liquid drug |
JP2001017539A (en) * | 1999-07-09 | 2001-01-23 | Terumo Corp | Blood collecting device |
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