WO2015078742A1 - Stabilisation de lipase dans des détergents pour la vaisselle - Google Patents

Stabilisation de lipase dans des détergents pour la vaisselle Download PDF

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Publication number
WO2015078742A1
WO2015078742A1 PCT/EP2014/075008 EP2014075008W WO2015078742A1 WO 2015078742 A1 WO2015078742 A1 WO 2015078742A1 EP 2014075008 W EP2014075008 W EP 2014075008W WO 2015078742 A1 WO2015078742 A1 WO 2015078742A1
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Prior art keywords
sodium
potassium
lipase
disodium
acid
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PCT/EP2014/075008
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German (de)
English (en)
Inventor
Hendrik Hellmuth
Timothy O'connell
Thomas Weber
Brian LAUFS
Kaoru Tachikawa
Ulrich Pegelow
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Henkel Ag & Co. Kgaa
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Application filed by Henkel Ag & Co. Kgaa filed Critical Henkel Ag & Co. Kgaa
Priority to EP14799793.6A priority Critical patent/EP3074494B1/fr
Publication of WO2015078742A1 publication Critical patent/WO2015078742A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38627—Preparations containing enzymes, e.g. protease or amylase containing lipase
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/04—Water-soluble compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2075—Carboxylic acids-salts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38663—Stabilised liquid enzyme compositions

Definitions

  • the present invention relates to enzyme-containing liquid detergents or cleaners, in particular hand dishwashing detergents, with improved enzyme stability.
  • Common detergents or cleaners on the market contain surfactants to remove dirt and stains.
  • combinations of a plurality of surfactants in particular from the group of anionic, nonionic, cationic and amphoteric surfactants, are used here.
  • These surfactants alone are often unable to remove dirt and stains sufficiently, so that in modern detergents or cleaning agents, other auxiliaries are used.
  • These other excipients include enzymes of various types such as proteases, amylases, cellulases, mannanases, pectate lyases.
  • hydrolytic enzymes such as proteases, amylases or lipases are part of numerous textile or dishwashing detergents because of their direct cleaning action.
  • Detergents or cleaning enzymes are formulated both in solid and in liquid form.
  • the group of solid enzyme preparations includes, in particular, the enzyme granules consisting of several ingredients, which in turn are preferably incorporated into solid washing or cleaning agents.
  • liquid or gel detergents or cleaners frequently contain liquid enzyme preparations, which, unlike the enzyme granules, are much less protected against external influences.
  • German Patent Application DE 20 38 103 (Henkel) teaches the stabilization of enzyme-containing dishwashing detergents by saccharides, while in European Patent EP 646 170 B1 (Procter & Gamble) propylene glycol is disclosed for enzyme stabilization in liquid detergents.
  • a second group of known stabilizers form borax, boric acids, boronic acids or their salts or esters.
  • These include, in particular, derivatives with aromatic groups, for example ortho, meta or para-substituted phenylboronic acids, in particular 4-formylphenylboronic acid (4-FPBA) or the salts or esters of the compounds mentioned.
  • 4-FPBA 4-formylphenylboronic acid
  • the latter compounds as enzyme stabilizers are disclosed, for example, in international patent application WO 96/41859 A1 (Novo Nordisk).
  • boric acids and boric acid derivatives for example, often have the disadvantage that they form unwanted by-products with other ingredients of a composition, in particular detergent ingredients, so that they are no longer available for the desired cleaning purpose or even as an impurity in the compositions concerned stay behind on the laundry. Furthermore, boric acids or borates are considered to be disadvantageous from an environmental point of view.
  • liquid detergents which contain 20 to 70% by weight of water, at least one amylase preparation, at least one calcium ion source and lactic acid or a lactic acid salt.
  • lipase is increasingly used in surfactant preparations, in particular in detergents or cleaners.
  • a lipase is an enzyme that catalyzes the hydrolysis of ester bonds in lipid substrates, especially in fats and oils. Lipases are therefore a group of esterases. Lipases are generally versatile enzymes that accept a variety of substrates, for example, aliphatic, alicyclic, bicyclic and aromatic esters, thioesters and activated amines. Lipases act against fat residues on surfaces such as soiled laundry or on soiled dishes by catalysing the hydrolysis (lipolysis) of said fat residues.
  • Lipases with broad substrate spectra are used in particular where inhomogeneous raw materials or substrate mixtures have to be reacted, for example in detergents and cleaners, since soiling may consist of differently structured fats and oils.
  • the lipases used in the washing or cleaning agents known from the prior art are usually of microbial origin and are usually derived from bacteria or fungi, for example the genera Bacillus, Pseudomonas, Acinetobacter, Micrococcus, Humicola, Trichoderma or Trichosporon. Lipases are usually prepared by biotechnological methods known per se by suitable Microorganisms produced, for example, by transgenic expression hosts of the genera Bacillus or by filamentous fungi.
  • lipases are suitable for use in liquid surfactant preparations. Many lipases do not show sufficient catalytic performance or stability in such formulations. In phosphonate-containing liquid surfactant preparations, this problem is even more serious, for example due to the complex-forming properties of the phosphonates or due to unfavorable interactions between the phosphonate and the lipase.
  • the object of the present invention was therefore to provide a method for the stabilization of lipases in liquid detergents or cleaners which at least improves at least one disadvantage of the prior art.
  • the object was also to provide liquid detergents or cleaners having improved lipase stability.
  • a liquid surfactant preparation containing the combination of such a lipase with one or more monovalent cations, divalent cations or trivalent cations or mixtures thereof has improved storage stability of the lipase contained.
  • this liquid washing and cleaning agent according to the invention has advantageous cleaning performance on lipase-sensitive soiling.
  • such a liquid washing and cleaning agent exhibits an improved cleaning performance on at least one, preferably on several lipase-sensitive soiling, in particular on textiles and / or hard surfaces, in particular on dishes.
  • Further preferred embodiments of inventive liquid detergents and cleaners show an advantageous cleaning performance with respect to at least one lipase-sensitive soiling at temperatures between 10 ° C and 80 ° C, preferably also at low temperatures, for example between 10 ° C and 50 ° C, between 10 ° C and 40 ° C or between 20 ° C and 40 ° C.
  • the present invention is therefore a particularly advantageous selection of a lipase and one salt or several salts for a liquid cleaning agent, in particular for a hand dishwashing detergent.
  • liquid cleaning agents are understood as meaning those which are flowable under normal conditions of use and whose viscosities can vary within a wide range.
  • the liquid preparations also include gelatinous or pasty agents, which may optionally have additional thickening agents known from the prior art.
  • the liquid agents are based on water.
  • a hand dishwashing detergent in the context of the present invention is a liquid detergent or cleaning agent particularly adapted for use in manual dishwashing. Hand dishwashing detergents are therefore particularly suitable for removing dirt from hard surfaces, have a good foaming power and also a special skin compatibility.
  • the hand dishwashing detergent according to the present invention is preferably characterized in that it has a foaming capacity of at least 250 mL, measured according to DIN Method 53 902, Part 2 (Ross-Miles test), preferably of at least 300 mL.
  • This advantageous foaming behavior is typically due to the fact that the hand dishwashing detergent preferably contains at least 5% by weight of an anionic surfactant, based on the total hand dishwashing detergent.
  • the total content of surfactant may, however, be significantly higher (see below).
  • the pH of a hand dishwashing detergent is preferably in the range of (inclusive) 4 to 9. Preferred are pH values between pH 5 and pH 8.5 (inclusive), most preferably a pH of 5 , 5 to 8.0 and most preferably from 7 to 8 (inclusive). Also, hand dishwashing detergents preferably do not contain bleaching agents, e.g. Sodium percarbonate and sodium borate. Skin compatibility can be assessed as irritating potential according to OECD method no. 404 determine. It is preferably at most 65%.
  • the invention thus relates, in a particularly preferred embodiment, to a liquid detergent or cleaning composition which has a minimum content of 5% by weight of an anionic surfactant, based on the total composition, and a pH of ⁇ 9.
  • An object of the present invention is a liquid washing or cleaning agent comprising at least one lipase and, based on the total weight of the composition, at least 0.05% by weight, preferably at least 0.15% by weight, particularly preferably at least 0, 25% by weight and very particularly preferably at least 0.35% by weight of at least one monovalent cation, at least one divalent cation or at least one trivalent cation or mixtures of these cations.
  • the proportion of the cation or cations in the total composition is from 0.35 to 5% by weight, preferably from 0.35 to 4% by weight, more preferably from 0.35 to 3% by weight, more preferably From 0.35 to 2% by weight and most preferably from 0.35 to 1% by weight, based on the total weight of the composition.
  • a lipase present in a liquid detergent according to the invention in particular in a hand dishwashing detergent according to the invention, has a lipolytic activity, that is, it is capable of hydrolysis (lipolysis) of lipids such as glycerides or cholesterol esters.
  • the lipase preferably contained in a surfactant preparation according to the invention is naturally present in a microorganism of the species Rhizopus oryzae or Mucor javanicus.
  • the lipase is a separate enzyme of the microorganism.
  • the lipase can thus be expressed in the microorganism from a nucleic acid sequence which is part of the chromosomal DNA of the microorganism in its wild-type form.
  • nucleic acid sequence is therefore present in the wild-type form of the microorganism and / or can be isolated from the wild-type form of the microorganism from this.
  • a lipase not present in the microorganism or the nucleic acid sequence coding for it would have been deliberately introduced into the microorganism with the aid of genetic engineering, so that the microorganism would have been enriched by the lipase or the nucleic acid sequence coding for it.
  • a lipase naturally present in a microorganism of the genus Rhizopus oryzae or Mucor javanicus may well have been produced recombinantly from another organism.
  • the fungus Rhizopus oryzae belongs to the class of Zygomycetes (subclass Incertae sedis), herein to the order Mucorales and here again to the family Mucoraceae and the genus Rhizopus.
  • the fungus Mucor javanicus also belongs to the class of Zygomycetes (subclass Incertae sedis), herein to the order Mucorales and here again to the family Mucoraceae, then herein to the genus Mucor.
  • the names Rhizopus oryzae and Mucor javanicus are the biological species names within the respective genus.
  • the surfactant preparation is characterized in that the lipase has an amino acid sequence which corresponds to the amino acid sequence shown in SEQ ID NO. 1 amino acid sequence is at least 80% identical. More preferably, the amino acid sequence is at least 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95% %, 96%, 97%, 98%, 99% and most preferably 100% identical to that shown in SEQ ID NO. 1 indicated amino acid sequence.
  • SEQ ID NO. 1 is the sequence of a mature (mature) lipase from Rhizopus oryzae.
  • Preferred lipases according to the invention are those from the company Amano Pharmaceuticals under the names Lipase M-AP10®, Lipase LE® and Lipase F® (also Lipase JV®). available lipase enzymes.
  • the Lipase F® is naturally present in Rhizopus oryzae.
  • the lipase M-AP10® is naturally present in Mucor javanicus.
  • Further particularly preferred lipases and lipase preparations are commercially available under the trade name Lipex from the company Novozymes (Denmark) and advantageously usable in the cleaning compositions according to the invention. Also particularly preferred is the lipase Lipex 100 L (ex Novozymes A / S, Denmark).
  • nucleic acid or amino acid sequences is determined by a sequence comparison. Such a comparison is made by assigning similar sequences in the nucleotide sequences or amino acid sequences to each other.
  • This sequence comparison is preferably based on the BLAST algorithm established and commonly used in the prior art (see, for example, Altschul, SF, Gish, W., Miller, W., Myers, EW & Lipman, DJ (1990) "Basic local alignment Biol. 215: 403-410, and Altschul, Stephan F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Hheng Zhang, Webb Miller, and David J. Lipman (1997).
  • the Clustal series see, for example, Chenna et al., 2003: Multiple sequence alignment with the Clustal series of programs, Nucleic Acid Research 31, 3497-3500
  • T-Coffee see, for example, Notredame et al (2000): T-Coffee: A novel method for multiple sequence alignments, J. Mol. Biol. 302, 205-217
  • Clustal see, for example, Chenna et al. (2003): Multiple sequence alignment with the Clustal series of programs, Nucleic Acid Research 31, 3497-3500
  • T-Coffee see, for example, Notredame et al Biol.
  • T-Coffee A novel method for multiple sequence alignments.
  • sequence comparisons and alignments are preferably created with the computer program Vector NTI® Suite 10.3 (Invitrogen Corporation, 1600 Faraday Avenue, Carlsbad, California, USA) with the default parameters specified.
  • Such a comparison allows a statement about the similarity of the compared sequences to each other. It is usually in percent identity, that is, the proportion of identical nucleotides or Ami noklarereste at the same or in an alignment corresponding positions indicated.
  • the broader concept of homology involves conserved amino acid substitutions in amino acid sequences, ie Amino acids with similar chemical activity, as they usually perform similar chemical activities within the protein. Therefore, the similarity of the compared sequences may also be given in percent homology or percent similarity.
  • Identity and / or homology information can be made about whole polypeptides or genes or only over individual regions. Homologous or identical regions of different nucleic acid or amino acid sequences are therefore defined by matches in the sequences. Such areas often have identical functions.
  • nucleic acid or amino acid sequence can be small and comprise only a few nucleotides or amino acids. Often, such small regions exert essential functions for the overall activity of the protein. It may therefore be useful to relate sequence matches only to individual, possibly small areas. Unless stated otherwise, identity or homology information in the present application, however, refers to the total length of the respectively indicated nucleic acid or amino acid sequence.
  • a surfactant preparation according to the invention is further characterized in that its cleaning performance corresponds at least to that of a surfactant preparation which contains a lipase which has an amino acid sequence according to SEQ ID NO. 1, wherein the cleaning performance is determined in a washing system containing a detergent in a dosage between 2.0 and 9.0 grams per liter of wash liquor and the lipase, wherein the lipases to be compared are used in the same activity and the cleaning performance against one or more soils russian / mineral oil on cotton, soot / olive oil on cotton, pigment / oil on cotton or skin fat (sebum) / carbon black, on cotton, especially against one or more of the stains
  • the lipase activity is determined in a customary manner, preferably as described in Bruno Stellmach, "Methods of determination enzymes for pharmacy, food chemistry, engineering, biochemistry, biology, medicine” (Steinkopff Verlag Darmstadt, 1988, p 172 ff).
  • lipase-containing samples are added to an olive oil emulsion in emulsifier-containing water and at 30 ° C and pH 9.0. This fatty acids are released. These are done with an autotitrator over 20 min. titrated continuously with 0.01 N sodium hydroxide solution so that the pH remains constant (“pH-stat titration"). Based on the sodium hydroxide consumption, the determination of the lipase activity takes place by reference to a reference lipase sample.
  • Another suitable method for measuring lipase activity is the release of a dye from a suitable pNP-labeled substrate.
  • lipases are formed as so-called pre-proteins, ie together with a propeptide and / or a signal peptide. Often the prodrug and / or signal peptide are N-terminal sequences. In the course of the folding and / or secretion process of the protein signal and / or propeptide are cleaved, so that after the cleavage of the pro- and / or signal peptide, the then mature lipase their catalytic activity without the originally present N-terminal amino acids exercises.
  • the mature (mature) lipases i. H. the enzymes processed after their preparation are preferred over the preproteins.
  • the lipases may also be modified by the cells producing them after production of the polypeptide chain, for example, by attachment of sugar molecules, formylations, aminations, etc. Such modifications are post-translational modifications and may, but do not, have an effect on the function of the lipase.
  • the lipase contained in a surfactant preparation according to the invention may be adsorbed to carriers and / or embedded in encapsulating substances in order to protect them against premature inactivation. In the washing or cleaning liquor, ie under conditions of use, the lipase is then released and can develop their lipolytic action.
  • the enzymes may be encapsulated for both the solid and liquid dosage forms, for example by spray-drying or extruding the enzyme solution together with a preferably natural polymer or in the form of capsules, for example those in which the enzymes are entrapped as in a solidified gel or in those of the core-shell type, in which an enzyme-containing core is coated with a water, air and / or chemical impermeable protective layer.
  • a preferably natural polymer or in the form of capsules for example those in which the enzymes are entrapped as in a solidified gel or in those of the core-shell type, in which an enzyme-containing core is coated with a water, air and / or chemical impermeable protective layer.
  • further active ingredients for example stabilizers, emulsifiers, pigments, bleaches or dyes, may additionally be applied.
  • Such capsules are applied by methods known per se, for example by shaking or rolling granulation or in fluid-bed processes.
  • such granules for example by applying polymeric film-forming agent, low in dust and storage stable due to the coating. Furthermore, it is possible to assemble two or more enzymes together so that a single granule has several enzyme activities.
  • the protein concentration can be determined by known methods, for example, the BCA method (bicinchoninic acid, 2,2'-biquinolyl-4,4'-dicarboxylic acid) or the biuret method (AG Gornall, CS Bardawill and MM David, J. Biol. Chem., 177 (1948), pp. 751-766).
  • the active enzyme protein content can be determined by means of active site titration of the lipase preparation according to Rotticci et al .: An active site titration method for lipases (Biochim. Here, various concentrations of the enzyme in a corresponding buffer system with an excess of inhibitor (methyl p-nitrophenyl-n-hexylphosphonat) provided and the liberated amount of p-nitrophenolate determined by spectrophotometry at 400 nm.
  • a surfactant preparation is to be understood as meaning any type of composition which comprises at least one surfactant.
  • a composition contains a surfactant as described below.
  • a liquid surfactant preparation according to the invention can be used as such or after dilution with water, in particular for the cleaning of textiles and / or hard surfaces.
  • Such dilution can be readily made by diluting a measured amount of the surfactant preparation in a further amount of water in certain weight ratios of surfactant preparation: water and optionally shaking this dilution to ensure uniform distribution of the surfactant formulation in the water.
  • Possible weight or volume ratios of the dilutions are from 1: 0 surfactant preparation: water to 1: 10,000 or 1: 20000 surfactant preparation: water, preferably from 1:10 to 1: 2000 surfactant preparation water.
  • a surfactant preparation in the sense of the present invention can therefore also be the washing or cleaning liquor itself.
  • the surfactant preparation is a washing, cleaning or disinfecting agent.
  • the detergents include all conceivable types of detergents, in particular detergents for textiles, carpets or natural fibers. They can be provided for manual and / or machine application.
  • the detergents also include washing aids, which are added to the actual detergent in the manual or machine textile washing, in order to achieve a further effect.
  • Detergents include all agents for cleaning and / or disinfecting hard surfaces also found in all of the above dosage forms, manual and automatic dishwashing detergents, carpet cleaners, abrasives, glass cleaners, toilet scavengers, etc.
  • Textile pre- and post-treatment are finally on the one hand such means with which the garment is brought into contact before the actual laundry, for example, for solving stubborn dirt, on the other hand, those in one of the actual textile laundry downstream step the laundry further desirable Features such as comfortable grip, crease resistance or give little static charge.
  • the fabric softeners are calculated.
  • Disinfectants are, for example, hand disinfectants, surface disinfectants and instrument disinfectants, which may also occur in the mentioned dosage forms.
  • a disinfectant preferably causes a germ reduction by a factor of at least 10 4 , that is to say that of originally 10,000 proliferating germs (so-called colony-forming units - CFU) survived no more than a single, with viruses in this regard are not considered as germs, since they have no cytoplasm and have no own metabolism.
  • Preferred disinfectants cause a germ reduction by a factor of at least 10 5 .
  • the cleaning agent contains a lipase preparation and optionally one or more further enzymes.
  • the salt of the monovalent cation, the divalent cation or the trivalent cation or mixtures of these cations which serves as cation ion source for the detergent composition according to the invention, is preferably selected from the inorganic or organic salts of alkaline earth metals, alkali metals, aluminum, iron, copper and zinc, preferably the alkali metals and alkaline earth metals, preferably from the halides, sulfates, sulfites, carbonates, bicarbonates, nitrates, nitrites, phosphates, formates, acetates, propionates, citrates, malates, tartrates, succinates, oxalates, lactates, and mixtures thereof.
  • the salt is selected from sodium chloride, calcium chloride, potassium chloride, sodium sulfate, potassium sulfate, sodium acetate, potassium acetate, sodium formate, potassium formate and mixtures thereof.
  • Particular preference is given here to calcium chloride, potassium chloride, potassium sulfate, sodium acetate, potassium acetate, sodium formate and potassium formate and mixtures thereof, in particular the potassium salts, ie potassium chloride, potassium sulfate, potassium acetate, potassium formate and mixtures thereof.
  • the cations are monovalent or divalent cations, more preferably monovalent cations, especially of potassium.
  • the total amount of the surfactants in the compositions according to the invention can vary within a broad range and, for example, be from 5 to 70% by weight, preferably from 8 to 55% by weight and in particular from 10 to 50% by weight.
  • suitable and preferred surfactants, enzymes, enzyme preparations, auxiliaries and other properties of the manual dishwashing detergents according to the present invention are described below.
  • the total amount of surfactants is 10% by weight.
  • the liquid detergent according to the invention is a hand dishwashing detergent.
  • the pH of the cleaning agent in particular the hand dishwashing detergent of the present invention, is preferably 5.5 to 9, particularly preferably 6 to 8.
  • the anionic surfactants are usually in situ as alkali metal, alkaline earth metal and / or mono-, di- or Trialkanolammoniumsalz and / or in the form of their with the corresponding alkali metal hydroxide, alkaline earth metal hydroxide and / or mono-, di- or trialkanolamine neutralizing corresponding acid used.
  • Particularly preferred are the sodium salts.
  • the agent according to the invention in particular a manual dishwashing detergent, in one preferred embodiment contains one or more anionic surfactants in an amount of 2 to 40% by weight, preferably 5 to 40% by weight, preferably 6 to 30% by weight, in particular 8 to 25% by weight.
  • the total amount of anionic surfactants in the composition is about 8.75% by weight.
  • Particularly preferred anionic surfactants used in manual dishwashing detergents include alkyl ether sulfates and alkyl sulfonates.
  • Alkyl ether sulfates are products of sulfation reactions on alkoxylated alcohols.
  • the person skilled in the art generally understands, under alkoxylated alcohols, the reaction products of alkylene oxide, preferably ethylene oxide, with alcohols, in the context of the present invention preferably with longer-chain alcohols, ie with aliphatic straight-chain or one or more branched, acyclic or cyclic, saturated or mono- or polyunsaturated, preferably straight-chain, acyclic, saturated, alcohols having 6 to 22, preferably 8 to 18, in particular 10 to 16 and particularly preferably 12 to 14 carbon atoms.
  • Another embodiment of the alkoxylation is the use of mixtures of the alkylene oxides, preferably the mixture of ethylene oxide and propylene oxide.
  • Very particularly preferred for the purposes of the present invention are lower ethoxylated Fatty alcohols having 1 to 4 ethylene oxide units (EO), in particular 1 to 2 EO, for example 2 EO, such as Na-Ci2-i4-fatty alcohol + 2EO sulfate.
  • the composition according to the invention in particular a manual dishwashing detergent, contains one or more alkyl ether sulfates in an amount of 2 to 40% by weight, preferably 5 to 40% by weight, preferably 6 to 30% by weight, in particular 8 up to 25% by weight.
  • the total amount of alkyl ether sulfates in the composition is about 8.75% by weight.
  • the alkyl sulfonates usually have an aliphatic straight-chain or mono- or poly-branched, acyclic or cyclic, saturated or mono- or polyunsaturated, preferably branched, acyclic, saturated, alkyl radical having 6 to 22, preferably 9 to 20, in particular 1 1 to 18 and particularly preferably 14 to 17 carbon atoms.
  • suitable alkyl sulfonates are the saturated alkanesulfonates, the unsaturated olefin esters and the ethers, which are formally derived from the alkoxylated alcohols on which the alkyl ether sulfates are based, in which terminal ether sulfonates (n-ether sulfonates) with sulfonate bound to the polyether chain are obtained Function and internal ether sulfonates (i-ether sulfonates) with alkyl-linked sulfonate function.
  • alkanesulfonates in particular alkanesulfonates having a branched, preferably secondary, alkyl radical, for example the secondary alkanesulfonate sec. Na C 13-7 alkanesulfonate (INCI Sodium C14-17 alkyl lake sulfonates).
  • a preferred manual dishwashing detergent contains one or more secondary alkyl sulfonates in an amount of 1 to 15% by weight, preferably 3 to 10% by weight, especially 4 to 8% by weight.
  • anionic surfactants which can be used are known to the person skilled in the art from the relevant prior art for detergents or cleaners. These include in particular aliphatic sulfates such as fatty alcohol sulfates, monoglyceride sulfates and ester sulfonates (sulfo fatty acid esters), lignosulfonates, alkylbenzenesulfonates, fatty acid cyanamides, anionic sulfates such as fatty alcohol sulfates, monoglyceride sulfates and ester sulfonates (sulfo fatty acid esters), lignosulfonates, alkylbenzenesulfonates, fatty acid cyanamides, anionic sulfates such as fatty alcohol sulfates, monoglyceride sulfates and ester sulfonates (sulfo fatty acid esters), lignosulfonates, alkylbenzenesulfon
  • Sulfosuccinic acid surfactants fatty acid isethionates, acylaminoalkanesulfonates (fatty acid tow), fatty acid sarcosinates, ether carboxylic acids and alkyl (ether) phosphates.
  • Suitable further anionic surfactants are anionic gemini surfactants with a di- phenyl oxide base structure 2 sulfonate groups and an alkyl group on one or both benzene rings of the formula O3S (C6H3R) 0 (C6H3R ') S03 ⁇ , with in which R is an alkyl radical examples game, 6, 10, 12 or 16 carbon atoms and R 'is R or H (Dowfax ® Dry hydrotropes Powder with Ci6-alkyl group (s); INCI Sodium Hexyldiphenyl ether sulfonates, disodium decyl phenyl ether disulfonates, Disodium Lauryl Phenyl Ether disulfonates, Disodium Cetyl phenyl ether disulfonates).
  • anionic surfactants are the anionic sulfosuccinic surfactants sulfosuccinates, sulfosuccinamates and sulfosuccinamides, especially sulfosuccinates and sulfosuccinamates, most preferably sulfosuccinates.
  • the sulfosuccinates are the salts of the mono- and diesters of sulfosuccinic acid HOOCCH (SO 3 H) CH 2 COOH, while the sulfosuccinamates are the salts of the monoamides of sulfosuccinic acid and the sulfosuccinamides are the salts of the diamides of sulfosuccinic acid.
  • the salts are preferably alkali metal salts, ammonium salts and mono-, di- or trialkanolammonium salts, for example mono-, di- or triethanolammonium salts, in particular lithium, sodium, potassium or ammonium salts, particularly preferably sodium or ammonium salts preferably sodium salts.
  • one or both carboxyl groups of the sulfosuccinic acid is preferably with one or two identical or different unbranched or branched, saturated or unsaturated, acyclic or cyclic, optionally alkoxylated alcohols having 4 to 22, preferably 6 to 20, in particular 8 to 18 , more preferably 10 to 16, most preferably 12 to 14 carbon atoms esterified.
  • esters of unbranched and / or saturated and / or acyclic and / or alkoxylated alcohols in particular unbranched, saturated fatty alcohols and / or unbranched, saturated, with ethylene and / or propylene oxide, preferably ethylene oxide, alkoxylated fatty alcohols having a degree of alkoxylation of 1 to 20, preferably 1 to 15, in particular 1 to 10, more preferably 1 to 6, most preferably 1 to 4.
  • the monoesters are preferred in the context of the present invention over the diesters.
  • a particularly preferred sulfosuccinate is Sulfobernsteinklarylpolyglykolester-di-sodium salt (lauryl EO sulfosuccinate, di-sodium salt; INCI Disodium Laureth Sulfosuccinate), for example, as Tego ® sulfosuccinate F 30 (Goldschmidt) with a sulfosuccinate of 30 parts by weight % is commercially available.
  • one or both form carboxyl groups of the sulfosuccinic acid preferably with a primary or secondary amine having one or two identical or different, unbranched or branched, saturated or unsaturated, acyclic or cyclic, optionally alkoxylated alkyl radicals having 4 to 22 , preferably 6 to 20, in particular 8 to 18, more preferably 10 to 16, most preferably 12 to 14 carbon atoms carries, a carboxylic acid amide.
  • Particular preference is given to unbranched and / or saturated and / or acyclic alkyl radicals, in particular unbranched, saturated fatty alkyl radicals.
  • sulfosuccinates and sulfosuccinamates designated according to INCI, which are described in more detail in the International Cosmetic Ingredient Dictionary and Handbook: Ammonium Dinonyl Sulfosuccinates, Ammonium Lauryl Sulfosuccinates, Diamonium Dimethicone Copolyol Sulfosuccinates, Diammonium Lauramido-MEA Sulfosuccinates, Diammonium Lauryl Sulfosuccinates, Diammonium Oleamido PEG-2 Sulfosuccinate, Diamyl Sodium Sulfosuccinate, Dicapryl Sodium Sulfosuccinate, Dicyclohexyl Sodium Sulfosuccinate, Diheptyl Sodium Sulfosuccinate, Dihexyl Sodium Sulfosuccinate, Diisobutyl Sodium Sulfosuccinate, Dioctyl Sodium Sul
  • Preferred anionic sulfosuccinic are imidosuccinate, mono-Na-sulfosuccinic acid diisobutyl ester (Monawet MB ® 45), mono-Na-sulfosuccinic acid di-octyl ester (Monawet MO-84 ® R2W, Rewopol SB ® DO 75), mono- Na-sulfosuccinic acid di-tridecyl (Monawet ® MT 70) Fettalkoholpolyglykolsulfosuccinat-Na-NHU salt (sulfosuccinate S-2), di-sodium sulfosuccinic acid mono-Ci2 / i4-3EO ester (Texapon ® SB 3) Natruimsulfobernsteinkladiiso- octyl (Texin DOS 75 ®) and di-Na-sulfosuccinic mono-Ci2
  • the agent according to the invention contains as anionic sulfosuccinic acid surfactants one or more sulfosuccinates, sulfosuccinamates and / or sulfosuccinamides, preferably sulfosuccinates and / or sulfosuccinamates, in particular sulfosuccinates, in an amount of usually 0.001 to 5% by weight, preferably 0.01 to 4 wt .-%, in particular 0.1 to 3 wt .-%, particularly preferably 0.2 to 2 wt .-%, most preferably 0.5 to 1, 5 wt .-%, for example 1 wt .-%.
  • anionic sulfosuccinic acid surfactants one or more sulfosuccinates, sulfosuccinamates and / or sulfosuccinamides, preferably sulfosuccinates and / or
  • amphoteric surfactants (amphoteric surfactants, zwitterionic surfactants) which can be used according to the invention include alkylamidoalkylamines, alkyl-substituted amino acids, acylated amino acids or biosurfactants, of which the betaines are preferred within the scope of the teaching according to the invention.
  • Suitable betaines which are mainly used in manual dishwashing detergents are the alkylbetaines, the alkylamidobetaines, the imidazolinium betaines, the sulfobetaines (INCI Sultaines) and the phosphobetaines and preferably satisfy formula I,
  • R [CO-X- (CH 2) n] x N + (R 2 ) (R 3 ) - (CH 2 ) m - [CH (OH) -CH 2 ] yY- (I)
  • R is a saturated or unsaturated C6 -22-alkyl radical, preferably Cs -is-alkyl radical, in particular a saturated Cio-16-alkyl radical, for example a saturated C 12-14 -alkyl radical,
  • X is NH, NR 4 with a Ci- 4 alkyl group R 4, O or S,
  • n is a number from 1 to 10, preferably 2 to 5, in particular 3,
  • x is 0 or 1, preferably 1,
  • R 2 , R 3 are independently of one another a C 1-4 -alkyl radical, optionally hydroxy-substituted, such as, for example
  • n is a number from 1 to 4, in particular 1, 2 or 3,
  • y is 0 or 1
  • Y is COO, SOs, OPO (OR 5 ) O or P (O) (OR 5 ) O, where R 5 is a hydrogen atom H or a C 1-6 -alkyl radical.
  • alkyl and alkyl amido betaines of the formula I with a carboxylate group are also called carbobetaines.
  • Preferred betaines are the alkylbetaines of the formula (Ia), the alkylamidobetaines of the formula (Ib), the sulfobetaines of the formula (Ic) and the amidosulfobetaines of the formula (Id), R is -N + (CH 3 ) 2 -CH 2 COO- (la)
  • R is -CO-NH- (CH 2 ) 3 -N + (CH 3 ) 2 -CH 2 COO- (Ib)
  • R is -N + (CH 3) 2 -CH 2 CH (OH) CH 2 SO 3 - (Ic)
  • R is -CO-NH- (CH 2 ) 3 -N + (CH 3) 2 -CH 2 CH (OH) CH 2 SO 3 - (Id) in which R has the same meaning as in formula I.
  • betaines are the carbo-betaines, in particular the carbo-betaines of the formula (Ia) and (Ib), most preferably the alkylamido-betaines of the formula (Ib).
  • betaines and sulfobetaines are the following compounds designated as INCI: almondamidopropyl betaines, apricotamidopropyl betaines, avocadamidopropyl betaines, babassuamidopropyl betaines, behenamidopropyl betaines, behenyl betaines, betaines, canolamidopropyl betaines, caprylic / capramidopropyl betaines, carnitines, cetyl betaines, cocamidoethyl betaines , Cocamidopropyl Betaine, Cocamidopropyl Hydroxysultaine, Coco-Betaine, Coco-Hydroxy-sultaine, Coco / Oleamidopropyl Betaine, Coco-Sultaine, Decyl Betaine, Dihydroxyethyl Oleyl Glycinate, Dihydroxyethyl Soy Glycinate, Dihydroxyethyl Stearyl Gly
  • the agent according to the invention comprises one or more betaines in an amount of 0.3 to 15% by weight, preferably 0.5 to 10% by weight, in particular 0.8 to 3% by weight.
  • the total amount of betaines in the composition is about 1.25% by weight.
  • the preferred surfactants a) alkyl ether sulfate, b) secondary alkanesulfonate and c) betaine are preferably present in a ratio a): b): c) of 5: 2: 1 to 3: 1: 1.
  • the following surfactants a) alkyl ether sulfate and b) betaine are present in the composition according to the invention, preferably in a ratio a): b) of 5: 1 to 10: 1, preferably 6: 1 to 8: 1, particularly preferred 7. 1
  • alkylamidoalkylamines are amphoteric surfactants of the formula (III)
  • R 9 is a saturated or unsaturated C6-22-alkyl radical, preferably Cs -is-alkyl radical, in particular a saturated Cio-16-alkyl radical, for example a saturated one
  • R 0 is a hydrogen atom H or a C 1-6 -alkyl radical, preferably H,
  • i is a number from 1 to 10, preferably 2 to 5, in particular 2 or 3,
  • R is a hydrogen atom H or CH 2 COOM (to M s.u.),
  • j is a number from 1 to 4, preferably 1 or 2, in particular 1,
  • k is a number from 0 to 4, preferably 0 or 1
  • Z is CO, SO2, OPO (OR 12) or P (0) (OR 12), wherein R 2 is a Ci- 4 alkyl or M (see below), and
  • M is a hydrogen, an alkali metal, an alkaline earth metal or a protonated alkanolamine, e.g. protonated mono-, di- or triethanolamine.
  • alkylamido alkylamines are the following compounds named according to INCI: Cocoamphodipropionic Acid, Cocobetainamido amphopropionates, DEA-Cocoamphodipropionate, Disodium Caproamphodiacetate, Disodium Caproamphodipropionate, Disodium Caprylo- amphodiacetates, Disodium Capryloamphodipropionate, Disodium Cocoamphocarboxyethylhy- droxypropylsulfonate, Disodium Cocoamphodiacetate, Disodium Cocoamphodipropionate, Disodium Isostearoamphodiacetate, Disodium Isostearoamphodipropionate , Disodium Laureth-5 diacetate Carboxyamphodiacetate, Disodium Lauroamphodiacetate, Disodium Lauroamphodipropionate, Disodium Oleoamphodipropionate, Disodium PPG-2-
  • Preferred alkyl-substituted amino acids are monoalkyl-substituted amino acids according to formula (IV),
  • NH-CH (R 4 HCH 2 ) u-COOM '(IV) is a saturated or unsaturated C 6-22 -alkyl radical, preferably C 1 -is-alkyl radical, in particular a saturated C 16 -alkyl radical, for example a saturated C 12-14 -alkyl radical alkyl,
  • R 14 is a hydrogen atom H or a C 1-6 -alkyl radical, preferably H,
  • u is a number from 0 to 4, preferably 0 or 1, in particular 1, and
  • M ' is a hydrogen, an alkali metal, an alkaline earth metal or a protonated alkanolamine, e.g. protonated mono-, di- or triethanolamine, is alkyl-substituted imino acids according to formula (V),
  • R 5 -N - [(CH 2 ) v -COOM "] 2 (V) in the R 5 is a saturated or unsaturated C 6-22-alkyl radical, preferably Cs-is-alkyl radical, in particular a saturated Cio-16-alkyl radical, for example a saturated C 12-14 -alkyl radical,
  • v is a number from 1 to 5, preferably 2 or 3, in particular 2, and
  • M is a hydrogen, an alkali metal, an alkaline earth metal or a protonated alkanolamine, for example protonated mono-, di- or triethanolamine, where M" in the two carboxy groups may have the same or different meanings, e.g. Is hydrogen and sodium or twice sodium, and mono- or dialkyl-substituted natural amino acids according to formula (VI),
  • R 6 is a saturated or unsaturated C 6-22 -alkyl radical, preferably C 1 -is-alkyl radical, in particular a saturated C 16 -alkyl radical, for example a saturated C 12-14 -alkyl radical,
  • R 7 is a hydrogen atom or a C 1-6 -alkyl radical, optionally hydroxyl- or amine-substituted, for example a methyl, ethyl, hydroxyethyl or aminopropyl radical,
  • R 8 is the residue of one of the 20 natural amino acids H 2 NCH (R 8 ) COOH, and
  • M '" is a hydrogen, an alkali metal, an alkaline earth metal or a protonated alkanolamine, for example protonated mono-, di- or triethanolamine.
  • alkyl-substituted amino acids are the aminopropionates according to formula (IVa),
  • Illustrative alkyl substituted amino acids are the following INCI compounds: Aminopropyl Laurylglutamine, Cocaminobutyric Acid, Cocaminopropionic Acid, DEA Lauraminopropionate, Disodium Cocaminopropyl Iminodiacetate, Disodium Dicarboxyethyl Copropylediamine, Disodium Lauriminodipropionate, Disodium Steariminodipropionate, Disodium Tallowiminodipropionate, Lauraminopropionic Acid, Lauryl Aminopropylglycine, Lauryl Diethylenediaminoglycines, myristaminopropionic acid, sodium C12-15 alkoxypropyl iminodipropionates, sodium cocaminopropionates, sodium lauraminopropionates, sodium lauriminodipropionates, sodium lauroyl methylaminopropionates, TEA lauraminopropionates, and TE
  • Acylated amino acids are amino acids, in particular the 20 natural ⁇ -amino acids which carry on the amino nitrogen the acyl radical R 9 CO of a saturated or unsaturated fatty acid R 9 COOH, where R 9 is a saturated or unsaturated C 6-22 -alkyl radical, preferably Cs-is-alkyl radical , in particular a saturated Cio-16-alkyl radical, for example a saturated C 12-14 -alkyl radical.
  • the acylated amino acids can also be used as the alkali metal salt, alkaline earth metal salt or alkanolammonium salt, for example mono-, di- or triethanolammonium salt.
  • acylated amino acids are the acyl derivatives summarized in accordance with INCI under Amino Acids, for example sodium cocoyl glutamate, lauroyl glutamic acid, capryloyl glycine or myristoyl methylalanine.
  • a combination of two or more different amphoteric surfactants in particular a binary Amphotensidkombination is used.
  • the amphoteric surfactant combination preferably contains at least one betaine, in particular at least one alkylamidobetaine, more preferably cocoamidopropylbetaine.
  • the amphoteric surfactants preferably contains at least one amphoteric surfactant is selected from the group comprising Natriumcarboxyethylkokosphosphoethylimidazolin (Phosphoteric ® TC- 6) C8 / io amidopropyl betaine (INCI caprylic / Capramidopropyl Betaine, Betaine Tego ® 810), N-2-hydroxyethyl-N-carboxymethyl fettklamido-ethylamine-Na (Rewoteric ® AMV) and N- caprylic / capric amidoethyl-N-ethyl-propionate-Na (Rewoteric AMVSF ®) and the betaine 3- (3-cocoamido-propyl) dimethylammonium
  • the agent according to the invention contains one or more amphoteric surfactants in an amount of more than 8% by weight. In yet another particular embodiment, the agent according to the invention contains one or more amphoteric surfactants in an amount of less than 2% by weight.
  • the nonionic surfactants used are preferably alkoxylated, advantageously ethoxylated, in particular primary, alcohols having preferably 8 to 18 carbon atoms and on average 1 to 12 moles of ethylene oxide (EO) per mole of alcohol, in which the alcohol radical can be linear or preferably methyl-branched in the 2-position or linear and methyl-branched radicals in the mixture can contain, as they are usually present in Oxoalkoholresten.
  • alcohol ethoxylates with linear radicals of alcohols of native origin having 12 to 18 carbon atoms, for example of coconut, palm, tallow or oleyl alcohol, and on average 2 to 8 EO per mole of alcohol are preferred.
  • the preferred ethoxylated alcohols include, for example, C12-14-alcohols with 3 EO, 4 EO or 7 EO, Cg-n-alcohol with 7 EO, cis-is alcohols with 3 EO, 5 EO, 7 EO or 8 EO, Ci2 -is-alcohols with 3 EO, 5 EO or 7 EO and mixtures of these, such as mixtures of Ci2-i4-alcohol with 3 EO and Ci2-is-alcohol with 7 EO.
  • the degrees of ethoxylation given represent statistical means which, for a particular product, may be an integer or a fractional number.
  • Preferred alcohol ethoxylates have a narrow homolog distribution (narrow rank ethoxylates, NRE).
  • fatty alcohols with more than 12 EO can also be used. Examples include tallow fatty alcohol with 14 EO, 25 EO, 30 EO or 40 EO.
  • Nonionic surfactants containing EO and PO groups together in the molecule can also be used according to the invention.
  • the hand dishwashing detergent contains a C 12-18 fatty alcohol with 7 EO or a C 13-15 oxo alcohol with 7 EO as nonionic surfactant.
  • nonionic surfactants is in the hand dishwashing detergent preferably 1 to 30 wt .-%, and preferably 2 to 25 wt .-%, each based on the total hand dishwashing detergent.
  • These nonionic surfactants in combination with an amine oxide have good cleaning performance on grease-soiled hard surfaces such as dishes.
  • Nonionic surfactants in the context of the invention are alkoxylates, but also alkylphenol polyglycol ethers, end-capped polyglycol ethers, mixed ethers and hydroxy mixed ethers and fatty acid polyglycol esters. Also suitable are block polymers of ethylene oxide and propylene oxide as well as fatty acid alkanolamides and fatty acid polyglycol ethers. Important classes of nonionic surfactants according to the invention are furthermore the amine oxides and the sugar surfactants, in particular the alkyl polyglucosides.
  • the amine oxides suitable according to the invention include alkylamine oxides, in particular alkyl dimethylamine oxides, alkylamidoamine oxides and alkoxyalkylamine oxides.
  • alkylamine oxides in particular alkyl dimethylamine oxides, alkylamidoamine oxides and alkoxyalkylamine oxides.
  • Preferred amine oxides satisfy formula II,
  • R 6 [CO-N H- (CH 2 ) w] z N + (R 7 ) (R 8 ) -O " (II) in which R 6 is a saturated or unsaturated C 6-22 -alkyl radical, preferably Cs -isole Alkyl radical, in particular a saturated Cio-16-alkyl radical, for example a saturated Ci2-14-alkyl radical in the Alkylamidoaminoxiden via a Carbonylamidoalky- len distr -CO-NH- (CH2) z- and in the Alkoxyalkylaminoxiden via a Oxalkalkylen embark -0 - (CH 2) z - is bonded to the nitrogen atom N, wherein z is in each case a number from 1 to 10, preferably 2 to 5, in particular 3, R 7 , R 8 independently of one another Ci-4-alkyl radical, optionally hydroxy-substituted as for example, a hydroxyethyl radical, in particular a methyl radical
  • Suitable amine oxides are the following compounds designated according to INCI: almondamidopropylamine oxides, babassuamidopropylamine oxides, behenamine oxides, cocamidopropyl amines oxides, cocamidopropylamine oxides, cocamine oxides, coco-morpholine oxides, decylamine oxides, decyltetradecylamine oxides, diaminopyrimidines oxides, dihydroxyethyl C8-10 Alkoxypropylamines oxides, dihydroxyethyl C9-1 alkoxypropylamines oxides, dihydroxyethyl C12-15 alkoxypropylamines oxides, dihydroxyethyl cocamines oxides, dihydroxyethyl lauramine oxides, dihydroxyethyl stearamines oxides, dihydroxyethyl tallowamine oxides, hydrogenated palm kernel amines oxides, hydrogenated tallowamine oxides, hydroxyethyl
  • Oleamidopropylamine Oxide Oleamine Oxide, Olivamidopropylamine Oxide, Palmitamidopropylamine Oxide, Palmitamine Oxide, PEG-3 Lauramine Oxide, Potassium Dihydroxyethyl Cocamine Oxide Phosphate, Potassium Trisphosphonomethylamine Oxide, Sesamidopropylamine Oxide, Soyamidopropylamine Oxide, Stearamidopropylamine Oxide, Stearamine Oxide, Tallowamidopropylamine Oxide, Tallowamine Oxide, Undecylenamidopropylamine Oxide and Wheat Germamidopropylamine Oxide.
  • Preferred amine oxides are, for example, cocamidopropylamine oxides (cocoamidopropylamine oxide), but also N-cocoalkyl-N, N-dimethylamine oxide, N-tallowalkyl-N, N-dihydroxyethylamine oxide,
  • Myristylcetyldimethylamine oxide or lauryldimethylamine oxide are examples of Myristylcetyldimethylamine oxide or lauryldimethylamine oxide.
  • the content of amine oxide is in the hand dishwashing detergent preferably 1 to 15 wt .-%, and preferably 2 to 10 wt .-%, each based on the total hand dishwashing detergent.
  • Sugar surfactants are known surface-active compounds, which include, for example, the sugar surfactant classes of the alkyl glucose esters, aldobionamides, gluconamides (sugar acid amides), glycerolamides, glycerol glycolipids, polyhydroxy fatty acid amide sugar surfactants (sugar amides) and alkyl polyglycosides.
  • Preferred sugar surfactants within the scope of the teaching according to the invention are the alkyl polyglycosides and the sugar amides and their derivatives, in particular their ethers and esters.
  • the ethers are the products of the reaction of one or more, preferably one, sugar hydroxy group with a compound containing one or more hydroxyl groups, for example C-22 alcohols or glycols such as ethylene and / or propylene glycol, where the sugar hydroxy group also comprises polyethylene glycol. and / or can carry polypropylene glycol.
  • the esters are the reaction products of one or more, preferably one, sugar hydroxy group with a carboxylic acid, in particular a C6-22 fatty acid.
  • Particularly preferred sugar amides satisfy the formula R'C (O) N (R ") [Z], in which R 'is a linear or branched, saturated or unsaturated acyl radical, preferably a linear unsaturated acyl radical, having 5 to 21, preferably 5 to 17, in particular 7 to 15, particularly preferably 7 to 13 carbon atoms, R "is a linear or branched, saturated or unsaturated alkyl radical, preferably a linear unsaturated alkyl radical, having 6 to 22, preferably 6 to 18, in particular 8 to 16, particularly preferred 8 to 14 carbon atoms, a Ci-5-alkyl radical, in particular a methyl, ethyl, propyl, isopropyl, n-butyl, isobutyl, tert-butyl or n-pentyl radical, or hydrogen and Z is a sugar residue ie a monosaccharide residue.
  • Particularly preferred sugar amides are the amides of glucose, the glucamides, for example la
  • alkylpolyglycosides are particularly preferred sugar surfactants within the scope of the teaching according to the invention and preferably satisfy the general formula RO (AO) a [G] x, in which R 'is a linear or branched, saturated or unsaturated alkyl radical having 6 to 22, preferably 6 to 18, in particular 8 to 16, particularly preferably 8 to 14 carbon atoms, [G] for a glycosidically linked sugar moiety and x for a number from 1 to 10 and AO for an alkyleneoxy group, for example an ethyleneoxy or Propylenoxyoli, and a for the average degree of alkoxylation from 0 to 20.
  • R ' is a linear or branched, saturated or unsaturated alkyl radical having 6 to 22, preferably 6 to 18, in particular 8 to 16, particularly preferably 8 to 14 carbon atoms
  • [G] for a glycosidically linked sugar moiety and x for a number from 1 to 10
  • AO for an alkyleneoxy group, for example an
  • the group (AO) a can also be different Alkyleneoxy include, for example, ethyleneoxy or propyleneoxy, wherein it is then a to the average Automatalkoxyltechniksgrad, ie the sum of Ethoxyltechniks- and Propoxyltechniksgrad acts.
  • the alkyl radicals R 'of the APG are linear unsaturated radicals having the stated number of carbon atoms.
  • APG are nonionic surfactants and are known substances that can be obtained by the relevant methods of preparative organic chemistry.
  • alkyl glycosides having a mean degree of oligomerization x of 1.1 to 3.0 are used. From an application point of view, those alkyl glycosides whose degree of oligomerization is less than 1.7 and in particular between 1.2 and 1.6 are preferred.
  • the glycosidic sugar used is preferably xylose, but especially glucose.
  • the alkyl or alkenyl radical R ' can be derived from primary alcohols having 8 to 18, preferably 8 to 14 carbon atoms. Typical examples are caproic alcohol, caprylic alcohol, capric alcohol and undecyl alcohol, and technical mixtures thereof, such as are obtained in the course of the hydrogenation of technical fatty acid methyl esters or in the course of the hydrogenation of aldehydes from Roelene's oxosynthesis.
  • the alkyl or alkenyl radical R ' is derived from lauryl alcohol, myristyl alcohol, cetyl alcohol, palmoleyl alcohol, stearyl alcohol, isostearyl alcohol or oleyl alcohol.
  • lauryl alcohol myristyl alcohol, cetyl alcohol, palmoleyl alcohol, stearyl alcohol, isostearyl alcohol or oleyl alcohol.
  • elaidyl alcohol petroselinyl alcohol, arachidyl alcohol, gadoleyl alcohol, behenyl alcohol, erucyl alcohol and technical mixtures thereof.
  • Correspondingly preferred alkylpolyglycosides are, for example, cocoa- and C 12-14 -alkylpolyglucoside having a DP degree of 1, 4 or 1.5, in particular cocoalkyl-1, 5-glucoside and C 12-14 -alkyl -1, 4-glucoside.
  • composition according to the invention may additionally contain one or more cationic surfactants (cation surfactants, INCI quaternary ammonium compounds), usually in an amount of 0.001 to 5% by weight, preferably 0.01 to 4% by weight, in particular 0.1 to 3 wt .-%, particularly preferably 0.2 to 2 wt .-%, most preferably 0.5 to 1, 5 wt .-%, for example 1 wt .-%.
  • Preferred cationic surfactants are the quaternary surface-active compounds, in particular with an ammonium, sulfonium, phosphonium, iodonium or arsonium group, which are also known as antimicrobial agents.
  • the agent can be designed with an antimicrobial effect or its possibly existing antimicrobial effect due to other ingredients can be improved.
  • Particularly preferred cationic surfactants are the quaternary ammonium compounds (QAV, INCI Quaternary Ammonium Compounds) according to the general formula (R l ) (R ll ) (R m ) (R lv ) N + X " , in which R 1 to R IV are identical or different Ci-22-alkyl, C7-28-aralkyl or heterocyclic radicals, or in the case of an aromatic compound such as pyridine-even three groups together with the nitrogen atom forming the heterocycle, for example a pyridinium or imidazolinium compound, and X " Halide ions, sulfate ions, hydroxide ions or similar anions.
  • at least one of the radicals has a chain length of 8 to 18, in particular 12 to 16, carbon atoms.
  • QACs are prepared by reacting tertiary amines with alkylating agents, e.g. Methyl chloride, benzyl chloride, dimethyl sulfate, dodecyl bromide, but also ethylene oxide produced.
  • alkylating agents e.g. Methyl chloride, benzyl chloride, dimethyl sulfate, dodecyl bromide, but also ethylene oxide produced.
  • alkylating agents e.g. Methyl chloride, benzyl chloride, dimethyl sulfate, dodecyl bromide, but also ethylene oxide produced.
  • alkylating agents e.g. Methyl chloride, benzyl chloride, dimethyl sulfate, dodecyl bromide, but also ethylene oxide produced.
  • the alkylation of tertiary amines with a long alkyl radical and two methyl groups succeeds particularly easily, and the quatern
  • Suitable QACs are, for example, benzalkonium chloride (N-alkyl-N, N-dimethylbenzylammonium chloride, CAS No. 8001-54-5), benzalkone B (m, p-dichlorobenzyldimethyl-C 12 -alkylammonium chloride, CAS no. 58390-78-6), benzoxonium chloride (benzyldodecyl-bis (2-hydroxyethyl) ammonium chloride), cetrimonium bromide (N-hexadecyl-N, N-trimethyl-ammonium bromide, CAS No.
  • benzalkonium chloride N-alkyl-N, N-dimethylbenzylammonium chloride, CAS No.
  • benzalkone B m, p-dichlorobenzyldimethyl-C 12 -alkylammonium chloride, CAS no. 58390-78-6
  • benzetonium chloride N, N-dimethyl-N- [2- [2- [p- (1,1,3,3-tetramethylbutyl) phenoxy] ethoxy] ethyl] benzyl ammonium chloride, CAS No. 121-54-0
  • dialkyldimethylammonium chlorides as Di-n-decyl-dimethyl-ammonium chloride (CAS No. 7173-51-5-5), didecyldimethylammonium bromide (CAS No. 2390-68-3), dioctyl-dimethyl-ammonium chloride, 1-cetylpyridinium chloride (CAS No.
  • QACs are the benzalkonium chlorides having Cs-ds-alkyl radicals, in particular C 12 -C 14 -alkyl-benzyldimethylammonium chloride.
  • a particularly preferred QAV is the Kokospentaethoxy- methylammonium methosulfate (INCI PEG-5 Cocomonium Methosulfate, Rewoquat ® CPEM).
  • no builder substances are present which have calcium-precipitating properties. Accordingly, an agent is preferred which contains in particular no carbonate-containing salts.
  • Organic builder substances which may be present in hand dishwashing detergents are, for example, the polycarboxylic acids which can be used in the form of their sodium salts, polycarboxylic acids meaning those carboxylic acids which carry more than one acid function. These are, for example, citric acid, adipic acid, succinic acid, glutaric acid, malic acid, tartaric acid, maleic acid, fumaric acid, sugar acids, aminocarboxylic acids, nitrilotriacetic acid (NTA), methylglycinediacetic acid (MGDA) and derivatives thereof and mixtures thereof.
  • Preferred salts are the salts of polycarboxylic acids such as citric acid, adipic acid, succinic acid, glutaric acid, tartaric acid, sugar acids and mixtures thereof.
  • polymeric polycarboxylates are suitable. These are, for example, the alkali metal salts of polyacrylic acid or polymethacrylic acid, for example, those having a molecular weight of 600 to 750,000 g / mol.
  • Suitable polymers are in particular polyacrylates, which preferably have a molecular weight of from 1,000 to 15,000 g / mol. Because of their superior solubility, the short-chain polyacrylates, which have molecular weights of from 1,000 to 10,000 g / mol, and particularly preferably from 1,000 to 5,000 g / mol, may again be preferred from this group.
  • copolymeric polycarboxylates in particular those of acrylic acid with methacrylic acid and of acrylic acid or methacrylic acid with maleic acid.
  • the polymers may also contain allylsulfonic acids, such as allyloxybenzenesulfonic acid and methallylsulfonic acid, as a monomer.
  • soluble builders such as, for example, citric acid, or acrylic polymers having a molar mass of from 1,000 to 5,000 g / mol in the liquid hand dishwashing detergents.
  • the water content of the preferred liquid and aqueous hand dishwashing detergent is usually from 15 to 90% by weight, preferably from 20 to 85% by weight, in particular from 30 to 80% by weight. %.
  • the composition of the invention may additionally contain one or more water-soluble organic solvents, usually in an amount of 0.1 to 30 wt .-%, preferably 1 to 20 wt .-%, in particular 2 to 15 wt .-%, particularly preferably 3 to 12 wt .-%, most preferably 4 to 8 wt .-%.
  • the solvent is used in the context of the teaching of the invention as needed in particular as a hydrotrope, viscosity regulator and / or additional cold stabilizer. It acts solubilizing in particular for surfactants and electrolyte as well as perfume and dye and thus contributes to their incorporation, prevents the formation of liquid-crystalline phases and has a share in the formation of clear products.
  • the viscosity of the agent according to the invention decreases with increasing amount of solvent. However, too much solvent can cause excessive viscosity drop.
  • a particularly preferred organic solvent which is particularly effective in stabilizing the enzymatic hand dishwashing detergents is glycerol and 1,2-propylene glycol.
  • solubilizer in particular for perfume and dyes, for example, alkanolamines and alkylbenzenesulfonates having 1 to 3 carbon atoms in the alkyl radical can be used in addition to the solvents described above.
  • compositions according to the invention may contain further ingredients.
  • these include, for example, other surfactants, additives for improving the flow and drying behavior, for adjusting the viscosity, for stabilization and other customary in manual dishwashing detergents and additives, such as UV stabilizers, perfume, pearlescing agents (INCI Opacifying Agents, such as glycol distearate, eg Cutina ® AGS Fa. Cognis, or mixtures comprising, for example, the Euperlane ® from.
  • the agent according to the invention may contain one or more additives from the group of surfactants, polymers and builders (builders), usually in an amount of 0.001 to 5% by weight, preferably 0, 01 to 4 wt .-%, in particular 0, 1 to 3 wt .-%, particularly preferably 0.2 to 2 wt .-%, most preferably 0.5 to 1, 5 wt .-%, for example 1 part by weight. %, wherein as described above on calcium-precipitating builders is largely dispensed with.
  • builders usually in an amount of 0.001 to 5% by weight, preferably 0, 01 to 4 wt .-%, in particular 0, 1 to 3 wt .-%, particularly preferably 0.2 to 2 wt .-%, most preferably 0.5 to 1, 5 wt .-%, for example 1 part by weight. %, wherein as described above on calcium-precipitating builders is largely dispensed with.
  • Polymers suitable as additives in particular maleic acid-acrylic acid copolymer, Na salt (Sokalan ® CP 5), modified polyacrylic acid Na salt are (Sokalan ® CP 10), modified polycarboxylate Na salt (Sokalan ® HP 25), polyalkylene oxide, modified heptamethyltrisiloxane (Silwet ® L-77), polyalkylene oxide-modified heptamethyltrisiloxane (Silwet ® L-7608) and polyether (copolymers of polydimethylsiloxanes having ethylene oxide / propylene oxide segments (polyether)), preferably water-soluble linear polyether having terminal polyether as Tegopren 5840 ® , Tegopren® ® 5843, Tegopren® ® 5847, Tegopren® ® 5851, Tegopren® ® 5863 or Tegopren® ® 5878th
  • suitable builders are, in particular polyaspartic acid-Na-salt, Ethylendiamintriacetatkokosalkylacetamid (Rewopol ® CHT 12), methylglycine-tri-sodium salt (Trilon ES ® 9964) and acetophosphonic (Turpinal SL ®).
  • Blends with surfactant or polymeric additives show in the case of Monawet MO-84 ® R2W, Tegopren ® 5843 and Tegopren 5863 ® synergism.
  • Tegopren grades 5843 and 5863 is less preferred when applied to hard surfaces of glass, especially glassware, since these can apply silicone surfactants to glass.
  • the additives mentioned are dispensed with.
  • the preferred viscosity for the liquid agent according to the invention is 20 ° C and a shear rate of 30 min "1 - measured with a Brookfield LV DV II viscometer and spindle 31 - in the range of 10 to 5,000 mPa-s, preferably 50 to 2,000 mPa-s, in particular 100 to 1000 mPa s, more preferably 200 to 800 mPa s, most preferably 300 to 700 mPa s, for example 300 to 400 mPa s
  • the viscosity of the composition according to the invention can - especially at a low surfactant content of the agent - Increased by thickening agents and / or - especially at a high surfactant content of the agent - are reduced by the water-soluble inorganic salts contained and by solvents.
  • polymeric thickeners are the polycarboxylates which have a thickening effect as polyelectrolytes, preferably homopolymers and copolymers of acrylic acid, in particular acrylic acid copolymers such as acrylic acid-methacrylic acid copolymers, and the polysaccharides, in particular heteropolysaccharides, and other customary thickening polymers.
  • Suitable polysaccharides or heteropolysaccharides are the polysaccharide gums, for example gum arabic, agar, alginates, carrageenans and their salts, guar, guar gum, tragacanth, gellan, Ramzan, dextran or xanthan and their derivatives, e.g. propoxylated guar, as well as their mixtures.
  • Other polysaccharide thickeners such as starches or cellulose derivatives, may be used alternatively, but preferably in addition to a polysaccharide gum, for example starches of various origins and starch derivatives, e.g.
  • Hydroxyethyl starch starch phosphate esters or starch acetates, or carboxymethyl cellulose or its sodium salt, methyl, ethyl, hydroxyethyl, hydroxypropyl, hydroxypropylmethyl or hydroxyethyl methyl cellulose or cellulose acetate.
  • a preferred polymeric thickener is the microbial anionic heteropolysaccharide xanthan gum, which is produced by Xanthomonas campestris and some other species under aerobic conditions with a molecular weight of 2-15 * 10 6 and for example, by Fa. Kelco under the trade name Keltrol ®, eg as cream-colored powder Keltrol ® T (transparent) or as white granules Keltrol ® RD (Readily Dispersable).
  • Keltrol ® eg as cream-colored powder Keltrol ® T (transparent) or as white granules Keltrol ® RD (Readily Dispersable).
  • Acrylic acid polymers suitable as polymeric thickeners are, for example, high molecular weight homopolymers of acrylic acid crosslinked with a polyalkenyl polyether, in particular an allyl ether of sucrose, pentaerythritol or propylene (INCI Carbomer), which are also referred to as carboxyvinyl polymers.
  • a polyalkenyl polyether in particular an allyl ether of sucrose, pentaerythritol or propylene
  • carboxyvinyl polymers Such polyacrylic acids are obtainable inter alia from Fa. BFGoodrich under the tradename Carbopol ®, such as Carbopol ® 940 (molecular weight about 4,000,000), Carbopol ® 941 (molecular weight approximately 1 .250.000) or Carbopol ® 934 (molecular weight approximately 3,000. 000).
  • acrylic acid copolymers are the following acrylic acid copolymers: (i) Copolymers of two or more monomers from the group of acrylic acid, methacrylic acid and their simple ester, preferably formed with C 1-4 alkanols (INCI acrylates copolymer), to which approx the copolymers of methacrylic acid, butyl acrylate and methyl methacrylate (CAS 25035-69-2) or of butyl acrylate and methyl methacrylate (CAS 25852-37-3) and which are obtainable for example from Messrs.
  • acrylic acid copolymers (i) Copolymers of two or more monomers from the group of acrylic acid, methacrylic acid and their simple ester, preferably formed with C 1-4 alkanols (INCI acrylates copolymer), to which approx the copolymers of methacrylic acid, butyl acrylate and methyl methacrylate (CAS 25035-69-2) or of butyl acrylate and methyl meth
  • Rohm & Haas under the trade names Aculyn ® and Acusol ® such as the anionic non-associative polymers Aculyn ® 33 (crosslinked), Acusol ® 810 and Acusol ® 830 (CAS 25852-37-3); (ii) crosslinked high molecular weight acrylic acid copolymers, such as those crosslinked with an allyl ether of sucrose or pentaerythritol copolymers of Cio-30-alkyl acrylates with one or more monomers from the group of acrylic acid, methacrylic acid and their simple, preferably with Ci-4-alkanols formed esters (INCI Acrylates / C 10-30 Alkyl Acrylate Crosspolymer) and which are for example available from the company.
  • Aculyn ® and Acusol ® such as the anionic non-associative polymers Aculyn ® 33 (crosslinked), Acusol ® 810 and Acusol ® 830 (CAS 25852-
  • Carbopol ® for example hydrophobized Carbopol ® ETD2623 and Carbopol ® 1382 (INCI Acrylates / C 10-30 Alkyl Acrylate Crosspolymer) and Carbopol ® AQUA 30 (formerly Carbopol ® EX 473).
  • the content of polymeric thickener is usually not more than 8 wt .-%, preferably between 0, 1 and 7 wt .-%, particularly preferably between 0.5 and 6 wt .-%, in particular between 1 and 5 wt .-% and most preferably between 1, 5 and 4% by weight, for example between 2 and 2.5% by weight.
  • the agent is free of polymeric thickeners.
  • one or more dicarboxylic acids and / or salts thereof may be added, in particular a composition of Na salts of adipic, succinic and glutaric acid, for example as available under the trade name Sokalan ® DSC is.
  • the use is advantageously carried out in amounts of 0.1 to 8 wt .-%, preferably 0.5 to 7 wt .-%, in particular 1, 3 to 6 wt .-% and particularly preferably 2 to 4 wt .-%.
  • a change in the dicarboxylic acid (salt) content can - especially in amounts above 2 wt .-% - contribute to a clear solution of the ingredients. Also, within certain limits, influencing the viscosity of the mixture by this means is possible. Furthermore, this component influences the solubility of the mixture. This component is particularly preferably used at high surfactant contents, in particular at surfactant contents above 30 wt .-%.
  • the agent according to the invention is preferably free from dicarboxylic acid (salts).
  • antibacterial component agents according to the invention may also contain elemental silver and / or a silver compound.
  • Lactic acid also has the advantage that, like benzoic acid or else salicylic acid as pH regulator and / or buffer substance, it can support or enhance the antibacterial action of the silver and / or the silver compound
  • the pH of the liquid agent according to the invention can also be adjusted by means of customary pH regulators, for example acids such as mineral acids or citric acid and / or alkalis such as sodium or potassium hydroxide, in which case the desired skin and hand compatibility - a range of 4 to 9, preferably 5.5 to 8.5, and especially 7.0 to 8.0, is preferred.
  • the enzyme-containing hand dishwashing detergents which contain potassium ions, in particular those of potassium acetate as potassium ion source, as enzyme stabilizer, at pH values above 7 lead to particularly high enzyme activities and thus enzyme stabilities even after storage of the compositions at 30 ° C.
  • Agents according to the invention having a pH above 7 are therefore very particularly preferred, in particular agents having a pH of 8.
  • the agent according to the invention may contain one or more buffer substances (INCI Buffering Agents), usually in amounts of 0.001 to 5 wt .-%, preferably 0.005 to 3 wt .-%, in particular 0.01 to 2 wt .-%, particularly preferably 0.05 to 1 wt .-%, most preferably 0.1 to 0 , 5 wt .-%, for example, 0.2 wt .-%.
  • buffer substances which are at the same time complexing agents or even chelating agents (chelating agents, INCI chelating agents).
  • Particularly preferred buffer substances are the citric acid or the citrates, in particular the sodium and potassium conduction rates, for example trisodium citrate-2H2O and tripotassium citrate H20.
  • a liquid agent may further contain hydrotropes.
  • hydrotropes are solubilizers. Suitable hydrotropes are, for example, urea, butyl glycol or aliphatic short-chain anionic or amphoteric solubilizers.
  • Another object of the present invention is the use of salts to increase the stability of enzymes, in particular lipase, in liquid detergents, in particular in hand dishwashing detergents.
  • the proportion of the salts is 0.6 to 5 wt .-%, preferably 0.75 to 4 wt .-%, particularly preferably 1 to 3 wt .-%, based on the total weight of the composition.
  • the salts of monovalent, divalent and / or trivalent cations are preferably selected from the inorganic or organic salts of alkaline earth metals, alkali metals aluminum, iron, copper and zinc, preferably the alkali metals and alkaline earth metals, preferably from the halides, sulfates, sulfites, carbonates, Bicarbonates, nitrates, nitrites, phosphates, formates, acetates, propionates, citrates, malates, tartrates, succinates, oxalates, lactates, and mixtures thereof.
  • the salt is selected from sodium chloride, calcium chloride, potassium chloride, sodium sulfate, potassium sulfate, sodium acetate, potassium acetate, sodium formate, potassium formate and mixtures thereof.
  • Particular preference is given to the use of calcium chloride, potassium chloride, potassium sulfate, sodium acetate, potassium acetate, sodium formate, potassium formate and mixtures thereof and in particular the use of potassium salts, ie potassium chloride, potassium sulfate, potassium acetate, potassium formate and mixtures thereof.
  • Another object of the present invention is a process for cleaning, in particular for the manual cleaning of hard surfaces, in particular dishes, comprising the use of a cleaning agent, in particular a hand dishwashing detergent according to the present invention.
  • a preferred embodiment of the present invention is a liquid detergent having a pH in the range of 4 to 9, containing water, an anionic surfactant, in particular an alkyl ether sulfate, an amphoteric surfactant, in particular a betaine, a lipase and optionally a preservative and a monovalent , divalent or trivalent cation, from a corresponding salt.
  • an anionic surfactant in particular an alkyl ether sulfate
  • an amphoteric surfactant in particular a betaine
  • a lipase and optionally a preservative and a monovalent , divalent or trivalent cation, from a corresponding salt.
  • a preferred embodiment of the present invention is a liquid detergent having a pH in the range of 4 to 9, preferably 5.5 to 8, containing 20 to 80 wt .-% water, 5 to 15 wt .-% of an anionic surfactant, in particular an alkyl ether sulfate, 0.8 to 3 wt .-% of an amphoteric surfactant, in particular a betaine, 0.001-2 wt .-% of a lipase and 0.05 to 0.15 wt .-% of a preservative and at least 0.05 wt .-% of a monovalent, divalent or trivalent cation of 1 to 3 wt .-% of a corresponding salt.
  • an anionic surfactant in particular an alkyl ether sulfate
  • an amphoteric surfactant in particular a betaine
  • 0.001-2 wt .-% of a lipase and 0.05 to 0.15 wt .-% of
  • a preferred embodiment of the present invention is a liquid detergent having a pH in the range of 4 to 9, preferably 5.5 to 8, containing about 80 wt .-% water, 8.75 wt .-% of an anionic surfactant, in particular an alkyl ether sulfate, 1, 25 wt .-% of an amphoteric surfactant, in particular a betaine, 0.05 to 1 wt .-% of a lipase and 0.05 to 0.15 wt .-% of a preservative and 0.35 to 1 Wt .-% of a monovalent, divalent or trivalent cation of 1, 5 wt .-% of a corresponding salt.
  • an anionic surfactant in particular an alkyl ether sulfate
  • 1, 25 wt .-% of an amphoteric surfactant in particular a betaine
  • 0.05 to 1 wt .-% of a lipase and 0.05 to 0.15 wt
  • the inventive enzyme-containing, in particular lipase-containing and stabilized by monovalent, divalent, and / or trivalent cations agent for use, ie in particular for cleaning the soiled dishes, in the form of a foam either directly on the surface to be cleaned or on a sponge a cloth, a brush or another, possibly moistened, cleaning aid may be applied.
  • a manually activated spray dispenser in particular selected from the group comprising aerosol spray dispenser, self-pressure spray dispenser, pump spray dispenser and trigger spray dispensers, in particular pump foam dispenser, as for example from the company Airspray, the company Taplast, the company Keltec or the Daiwa Can Company.
  • trigger bottles pump spray dispensers and trigger spray dispensers with a polyethylene, polypropylene or polyethylene terephthalate container are also suitable.
  • trigger bottles are offered for example by the company Afa-Polytec.
  • the spray head is preferably equipped with a foam nozzle.
  • the agent can also with the addition of a suitable propellant (eg n-butane, a Propane / butane mixture, carbon dioxide, nitrogen or a C02 / N2 mixture) into a corresponding aerosol spray bottle.
  • a suitable propellant eg n-butane, a Propane / butane mixture, carbon dioxide, nitrogen or a C02 / N2 mixture
  • such a spray dispenser is less preferred.
  • the agent according to the invention in the form of a product from the agent according to the invention and a spray or foam dispenser, in particular pump foam dispenser, be placed on the market.
  • the inventive particular liquid hand dishwashing detergent is applied either directly, that is undiluted, for example by means of a sponge, to the surface to be cleaned and then removed again with water.
  • the hand dishwashing detergent according to the invention can first be diluted with water to concentrations of 1: 1 to 1: 1000, and then the resulting cleaning solution is brought into contact with the surface to be cleaned.
  • Lipex 100 L (ex Novozymes A / S, Denmark) was incorporated into the following formulation:
  • the quantities are understood as wt .-%, based on the total weight of the total composition.
  • Suitable methods for measuring the lipase activity include pH-stat titration, release of a dye from a suitable pNP-labeled substrate, or other methods well known to those skilled in the art, some of which are included in the general part of the description of the present invention.

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Abstract

L'invention concerne un produit de nettoyage ou de lavage liquide qui contient au moins une lipase et qui peut contenir des cations monovalents, divalents ou trivalents qui sont utilisés pour stabiliser la lipase.
PCT/EP2014/075008 2013-11-27 2014-11-19 Stabilisation de lipase dans des détergents pour la vaisselle WO2015078742A1 (fr)

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DE102013224250.6A DE102013224250A1 (de) 2013-11-27 2013-11-27 Lipasestabilisierung in Geschirrspülmitteln
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3074494B1 (fr) 2013-11-27 2018-04-04 Henkel AG & Co. KGaA Stabilisation de lipase dans des détergents pour la vaisselle
EP3284811B1 (fr) 2015-06-04 2018-12-12 The Procter & Gamble Company Composition de détergent liquide pour lavage de la vaisselle à la main
EP3284805B1 (fr) 2016-08-17 2020-02-19 The Procter & Gamble Company Composition de nettoyage
US11439691B2 (en) 2017-03-03 2022-09-13 Nordmark Pharma Gmbh Aqueous solution of burlulipase comprising calciumions

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DE102019133382A1 (de) * 2019-12-06 2021-06-10 Henkel Ag & Co. Kgaa Handgeschirrspülmittelzusammensetzung mit Lipase

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3074494B1 (fr) 2013-11-27 2018-04-04 Henkel AG & Co. KGaA Stabilisation de lipase dans des détergents pour la vaisselle
EP3284811B1 (fr) 2015-06-04 2018-12-12 The Procter & Gamble Company Composition de détergent liquide pour lavage de la vaisselle à la main
EP3284805B1 (fr) 2016-08-17 2020-02-19 The Procter & Gamble Company Composition de nettoyage
US11439691B2 (en) 2017-03-03 2022-09-13 Nordmark Pharma Gmbh Aqueous solution of burlulipase comprising calciumions

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