WO2015062167A8 - Metrnl蛋白在制备降血脂降血糖药物中的应用 - Google Patents

Metrnl蛋白在制备降血脂降血糖药物中的应用 Download PDF

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Publication number
WO2015062167A8
WO2015062167A8 PCT/CN2014/000949 CN2014000949W WO2015062167A8 WO 2015062167 A8 WO2015062167 A8 WO 2015062167A8 CN 2014000949 W CN2014000949 W CN 2014000949W WO 2015062167 A8 WO2015062167 A8 WO 2015062167A8
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WO
WIPO (PCT)
Prior art keywords
application
hypoglycemic medicine
preparing
metrnl
hypolipidemic
Prior art date
Application number
PCT/CN2014/000949
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English (en)
French (fr)
Other versions
WO2015062167A1 (zh
Inventor
缪朝玉
李志勇
王培�
Original Assignee
中国人民解放军第二军医大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201310525184.9A external-priority patent/CN103536904B/zh
Priority claimed from CN201310525181.5A external-priority patent/CN103536903B/zh
Application filed by 中国人民解放军第二军医大学 filed Critical 中国人民解放军第二军医大学
Publication of WO2015062167A1 publication Critical patent/WO2015062167A1/zh
Publication of WO2015062167A8 publication Critical patent/WO2015062167A8/zh
Priority to US15/137,606 priority Critical patent/US20160251405A1/en
Priority to US15/729,420 priority patent/US10342852B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

本发明提供了Metrnl蛋白在制备降血脂、降血糖药物或保健食品中的应用。本发明还提供了Metrnl脂肪特异性过表达小鼠的制备方法。
PCT/CN2014/000949 2013-10-29 2014-10-27 Metrnl蛋白在制备降血脂降血糖药物中的应用 WO2015062167A1 (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US15/137,606 US20160251405A1 (en) 2013-10-29 2016-04-25 Application of metrnl protein in preparing hypolipidemic, hypoglycemic medicine
US15/729,420 US10342852B2 (en) 2013-10-29 2017-10-10 Methods of reducing blood glucose or triglyceride levels by administration of METRNL protein

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201310525184.9A CN103536904B (zh) 2013-10-29 2013-10-29 Metrnl蛋白在制备降血糖药物方面的应用
CN201310525184.9 2013-10-29
CN201310525181.5A CN103536903B (zh) 2013-10-29 2013-10-29 Metrnl蛋白在制备降血脂药物方面的应用
CN201310525181.5 2013-10-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US15/137,606 Continuation US20160251405A1 (en) 2013-10-29 2016-04-25 Application of metrnl protein in preparing hypolipidemic, hypoglycemic medicine

Publications (2)

Publication Number Publication Date
WO2015062167A1 WO2015062167A1 (zh) 2015-05-07
WO2015062167A8 true WO2015062167A8 (zh) 2015-12-30

Family

ID=53003220

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2014/000949 WO2015062167A1 (zh) 2013-10-29 2014-10-27 Metrnl蛋白在制备降血脂降血糖药物中的应用

Country Status (2)

Country Link
US (2) US20160251405A1 (zh)
WO (1) WO2015062167A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016204700A1 (de) 2016-03-22 2017-09-28 Universität Rostock Rekombinante Herstellung von Subfatin
CN109420158A (zh) * 2017-09-01 2019-03-05 上海风劲生物医药科技有限公司 Metrnl抗血栓用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0639225B1 (en) * 1992-04-30 2002-10-16 N.V. Innogenetics S.A. New polypeptides and peptides, nucleic acids coding for them, and their use in the field of tumor therapy, inflammation or immunology
WO2010009732A1 (en) * 2008-07-24 2010-01-28 Nsgene A/S Therapeutic use of a growth factor, metrnl
WO2014116556A2 (en) * 2013-01-25 2014-07-31 Dana-Farber Cancer Institute, Inc. Compositions and methods for regulating thermogenesis and muscle inflammation using metrnl and metrn
CN103536904B (zh) * 2013-10-29 2015-02-18 中国人民解放军第二军医大学 Metrnl蛋白在制备降血糖药物方面的应用
CN103536903B (zh) * 2013-10-29 2015-04-15 中国人民解放军第二军医大学 Metrnl蛋白在制备降血脂药物方面的应用

Also Published As

Publication number Publication date
US20160251405A1 (en) 2016-09-01
WO2015062167A1 (zh) 2015-05-07
US20180030102A1 (en) 2018-02-01
US10342852B2 (en) 2019-07-09

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