WO2015059766A1 - Electroosmotic flow pump - Google Patents
Electroosmotic flow pump Download PDFInfo
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- WO2015059766A1 WO2015059766A1 PCT/JP2013/078574 JP2013078574W WO2015059766A1 WO 2015059766 A1 WO2015059766 A1 WO 2015059766A1 JP 2013078574 W JP2013078574 W JP 2013078574W WO 2015059766 A1 WO2015059766 A1 WO 2015059766A1
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- dielectric porous
- permeable electrode
- porous film
- dielectric
- water permeable
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/006—Micropumps
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/04—Pumps for special use
Definitions
- the present invention relates to an electroosmotic pump.
- micropump which are a type of microfluidic device
- a micropump Conventionally, a mechanical micropump is known as a micropump.
- the mechanical micro pump is composed of precision parts. For this reason, there is a limit to cost reduction and miniaturization in the mechanical micropump. From such a background, an electroosmotic pump is attracting attention as a micro pump that replaces a mechanical pump (see, for example, Patent Document 1).
- the electroosmotic flow is a flow of liquid that is generated when a voltage is applied to the electric double layer where the liquid and the solid are in contact. Electroosmotic flow was discovered with electrophoresis by physicist Royce in the early 19th century. In contrast to electrophoresis in which solutes and charged particles move in a liquid, solids are fixed in electroosmotic flow. For this reason, the bulk liquid moves when electroosmotic flow occurs. The electroosmotic flow is observed in a liquid or ionic liquid composed of polarizable molecules including a protic solvent such as water or alcohol. A pump for feeding liquid using this electroosmotic flow is an electroosmotic flow pump.
- Patent Document 1 describes an example of an electroosmotic flow pump.
- a conventional electroosmotic pump such as the electroosmotic pump described in Patent Document 1
- the main object of the present invention is to provide a novel electroosmotic pump capable of AC drive.
- the first electroosmotic pump according to the present invention includes a dielectric porous membrane, a first water permeable electrode, and a second water permeable electrode.
- the first water permeable electrode is disposed on one side of the dielectric porous film.
- the second water permeable electrode is disposed on the other side of the dielectric porous film.
- the hydrophilicity of the main surface on the first water permeable electrode side of the dielectric porous membrane is different from the hydrophilicity of the main surface on the second water permeable electrode side.
- each of the first water permeable electrode and the second water permeable electrode includes a conductive porous film, a conductive mesh, a conductive fine particle sintered film formed on the surface of the dielectric porous film, Or it is preferable that it is a pattern electrode printed on the porous insulating film.
- the dielectric porous film may have a hydrophilic layer on one main surface.
- the second electroosmotic pump according to the present invention includes a dielectric porous membrane, a first water permeable electrode, and a second water permeable electrode.
- the first water permeable electrode is disposed on one side of the dielectric porous film.
- the second water permeable electrode is disposed on the other side of the dielectric porous film.
- the zeta potential on one side of the dielectric porous film and the zeta potential on the other side are different from each other, or the streaming potential on one side of the dielectric porous film is different from the streaming potential on the other side.
- a third electroosmotic pump includes a dielectric porous membrane, a first water permeable electrode, and a second water permeable electrode.
- the first water permeable electrode is disposed on one side of the dielectric porous film.
- the second water permeable electrode is disposed on the other side of the dielectric porous film.
- the dielectric porous membrane is formed so that when an alternating voltage is applied between the first water permeable electrode and the second water permeable electrode, the liquid in the dielectric porous membrane is changed to the first water permeable electrode side. It is comprised so that the force to selectively move from one side of the 2nd water-permeable electrode side to the other may be provided.
- the dielectric porous film includes the laminated first dielectric porous film and second dielectric porous film, and one principal surface is It may be configured by the first dielectric porous film, and the other main surface may be configured by the second dielectric porous film.
- the first to third electroosmotic pumps according to the present invention may further include a power source that applies an AC voltage between the first permeable electrode and the second permeable electrode.
- the power source preferably applies an AC voltage having a frequency of 1 MHz or less.
- the thickness of the dielectric porous film is preferably in the range of 5 ⁇ m to 100 ⁇ m.
- the ratio of the area of the first and second water permeable electrodes to the square of the thickness of the dielectric porous membrane is preferably larger than 100.
- the average pore diameter in the dielectric porous membrane is preferably in the range of 10 nm to 50 ⁇ m.
- each of the first and second water permeable electrodes preferably has a through hole penetrating in the thickness direction.
- the dielectric porous film preferably has a through-hole penetrating in the thickness direction.
- the hydrophilicity of the main surface on the first water permeable electrode side of the dielectric porous membrane is different from the hydrophilicity of the main surface on the second water permeable electrode side.
- the first permeable electrode preferably has a hydrophilic layer on the surface layer opposite to the dielectric porous membrane.
- FIG. 1 is a schematic cross-sectional view of a liquid delivery module including an electroosmotic flow pump according to the first embodiment.
- FIG. 2 is a schematic cross-sectional view of a part of the liquid-feeding film in the first embodiment.
- FIG. 3 is a schematic cross-sectional view of a part of the liquid feeding film in the second embodiment.
- FIG. 4 is a schematic diagram of the hydrophilic layer of the liquid-feeding film in the second embodiment.
- FIG. 5 is a schematic cross-sectional view of a part of the liquid feeding film in the third embodiment.
- FIG. 6 is a fracture cross-sectional photograph of the track-etched film used in Example 1.
- FIG. 7 is a graph showing the relationship between the applied voltage and the flow rate in Example 1.
- FIG. 8 is a graph showing the relationship between applied voltage and flow rate in Examples 1 to 3.
- FIG. 1 is a schematic cross-sectional view of an electroosmotic flow pump according to the present embodiment.
- FIG. 2 is a schematic cross-sectional view of a part of the liquid feeding film in the present embodiment.
- the liquid feeding module 1 includes a fixing jig 10 and 11 and an electroosmotic pump 2 attached to the fixing jig 10 and 11.
- the electroosmotic pump 2 includes a liquid feeding film 20 sandwiched between a first water permeable electrode and a second water permeable electrode.
- the electroosmotic pump 2 is supplied with AC power.
- the liquid feeding film 20 partitions the first storage unit 12 and the second storage unit 13.
- a liquid storage tank 30 is connected to the second storage unit 13. Liquid is supplied from the liquid reservoir 30 to the first reservoir 12.
- the liquid supplied to the first storage unit 12 is supplied to the second storage unit 13 by the liquid transfer film 20 and is discharged from the discharge port 14 provided in the second storage unit 13.
- the 1st storage part 12 and the 2nd storage part 13 are for guide
- the first and second reservoirs 12 and 13 do not necessarily have a specific volume.
- the first reservoir 12 and the second reservoir 13 may be part of any channel flow path of the microfluidic device.
- the 1st storage part 12 and the 2nd storage part 13 may each be satisfy
- the liquid feeding film 20 may have a flat plate shape, a bent structure, a structure having a plurality of irregularities, or a folded structure. In that case, the ratio of the actual surface area to the area of the liquid delivery film 20 in plan view ((actual area of the surface of the liquid delivery film 20) / (area of the liquid delivery film 20 in plan view)) may be increased. it can. Therefore, the liquid feeding capability of the electroosmotic flow pump 2 can be improved.
- the liquid feeding film 20 has a dielectric porous film 21.
- the dielectric porous film 21 is made of an appropriate dielectric.
- the dielectric porous film 21 is, for example, a polymer film made of polycarbonate (PC), polyester (PET), polyimide (PI) or the like, ceramic, silicon, glass, aluminum oxide sintered body, aluminum nitride sintered body. Further, it may be composed of an inorganic film made of a mullite sintered body, a silicon carbide sintered body, a silicon nitride sintered body, a glass ceramic sintered body, or the like.
- the dielectric porous film 21 may be, for example, a monolithic porous body.
- the dielectric porous film 21 is preferably a track-etched film.
- the track-etched film means a track-etched film.
- Track etching is chemical etching that forms a linear track by irradiating a film with strong heavy ions.
- the dielectric porous film 21 is a polymer film or an inorganic film, pores can be formed by laser light irradiation.
- the dielectric porous film 21 is preferably a film having open cells, and is preferably a film having a plurality of through holes penetrating in the thickness direction.
- the track-etched film has many through holes penetrating in the thickness direction.
- the thickness of the dielectric porous film 21 is not particularly limited, but is preferably about 5 ⁇ m to 100 ⁇ m, and more preferably 10 ⁇ m to 60 ⁇ m. By setting the thickness of the dielectric porous film 21 to such a thickness, it is possible to antagonize the thickness of the dielectric porous film 21 and the thickness of the electric double layer to be formed. Therefore, the operation of the electroosmotic flow pump 2 is suitable.
- the average pore diameter in the dielectric porous film 21 is preferably 10 nm to 50 ⁇ m, more preferably 20 nm to 10 ⁇ m, and further preferably 50 nm to 2 ⁇ m. If the average pore diameter in the dielectric porous film 21 is too small, the flow resistance may be large and the liquid feeding amount may be small. If the average pore size in the dielectric porous film 21 is too large, the water pressure of the liquid feeding is lowered, and the energy efficiency of the electroosmotic flow may be deteriorated.
- the aperture ratio of the dielectric porous film 21 is preferably 1% to 50%, and more preferably 3% to 30%. If the aperture ratio of the dielectric porous film 21 is too high, adjacent holes are likely to be fused, and a problem may occur in the self-supporting property of the film. If the aperture ratio of the dielectric porous film 21 is too low, the liquid feeding amount may be small.
- Pore density of the dielectric porous film 21, 4 E2 / c is preferably m is 2 ⁇ 5E 13 / c m 2 , 3E 4 / cm 2 ⁇ 7.5 E1 0 / cm 2 and it is further preferable. If the pore density of the dielectric porous film 21 is too high, the aperture ratio may be too high or the average pore size may be too small. If the pore density of the dielectric porous film 21 is too low, the energy efficiency of the electroosmotic flow may be deteriorated.
- a first water permeable electrode 22 is provided on the second reservoir 13 side of the dielectric porous film 21.
- a second water permeable electrode 23 is provided on the first reservoir 12 side of the dielectric porous film 21.
- the first and second water permeable electrodes 22 and 23 may be provided so that an electric double layer is formed on the surface of the dielectric porous film 21 when the liquid is supplied.
- Each of the first and second permeable electrodes 22 and 23 is not necessarily in contact with the dielectric porous film 21.
- a conductive rubber having a high elastic modulus may be interposed between each of the first and second water permeable electrodes 22 and 23 and the dielectric porous film 21.
- the first and second permeable electrodes 22 and 23 are provided so that liquid can pass in the thickness direction.
- Each of the first and second water permeable electrodes 22 and 23 preferably has a through-hole penetrating in the thickness direction.
- the through holes of the first and second permeable electrodes 22 and 23 and the through holes of the dielectric porous film 21 are preferably connected.
- the first and second water permeable electrodes 22 and 23 are each made of, for example, a conductive material such as metal on the dielectric porous film 21 so that the pores of the dielectric porous film 21 are not completely closed. It can be formed by forming a film. Moreover, the 1st and 2nd water-permeable electrodes 22 and 23 may be comprised by patterned electrodes, such as a mesh electrode, a comb-shaped electrode, a staggered electrode, and a fractal pattern electrode, respectively.
- the material of the first and second water permeable electrodes 22 and 23 is not particularly limited as long as it is a conductive material, but the first and second water permeable electrodes 22 and 23 are made of a highly conductive material. Is preferred. Specifically, each of the first and second permeable electrodes 22 and 23 is composed of at least one metal of gold, silver and copper, a composite material mainly composed of carbon such as carbon nanotube, indium tin oxide (ITO). ) Or other transparent conductive oxide (Transparent Conductive Oxide) or the like.
- ITO indium tin oxide
- Transparent Conductive Oxide Transparent Conductive Oxide
- the electroosmotic flow pump 2 includes an AC power source 40.
- An AC voltage is applied between the first and second permeable electrodes 22 and 23 by the AC power source 40.
- the AC power supply 40 preferably applies an AC voltage having a frequency of 1 MHz or less between the first and second permeable electrodes 22 and 23, and more preferably applies an AC voltage of 0.5 Hz to 20 kHz. More preferably, an alternating voltage of 1 Hz to 100 Hz is applied. If the frequency of the AC voltage applied between the first and second permeable electrodes 22 and 23 is too high, the electroosmotic pump 2 may not operate properly.
- the dielectric porous membrane 21 has a hydrophilic layer 21a on the main surface on the first water permeable electrode 22 side.
- a hydrophilic layer 21a on the main surface on the first water permeable electrode 22 side.
- one surface layer of the dielectric porous film 21 is a hydrophilic layer 21a.
- one surface of the dielectric porous film 21 has a hydrophilic treatment or a hydrophilic functional group typified by plasma treatment such as atmospheric pressure plasma chemical treatment.
- the hydrophilic layer 21a can be formed by chemically modifying with molecules.
- a polyurethaneurea containing a phosphorylcholine group is preferably used as the polymer containing a hydrophilic functional group.
- polylysine, polyallylamine, etc. which have many amino groups in a molecular chain can also be used as a polymer containing a hydrophilic functional group.
- the method of chemically modifying the surface of the dielectric porous film 21 with a molecule having a hydrophilic functional group is not limited to these, and a chemical modification hydrophilization technique known to those skilled in the art can be applied.
- the hydrophilicity of the surface of the hydrophilic layer 21a is higher than the hydrophilicity of the main surface of the dielectric porous film 21 on the second water permeable electrode 23 side. Therefore, the zeta potential of the main surface of the dielectric porous membrane 21 on the first water permeable electrode 22 side and the zeta potential of the main surface on the second water permeable electrode 23 side are different from each other, or the dielectric
- the streaming potential of the main surface of the body porous membrane 21 on the first permeable electrode 22 side is different from the streaming potential of the main surface on the second permeable electrode 23 side.
- the magnitude of the zeta potential on the main surface of the dielectric porous film 21 on the first water permeable electrode 22 side is larger than the zeta potential on the main surface on the second water permeable electrode 23 side.
- the flow potential on the main surface of the dielectric porous membrane 21 on the first water permeable electrode 22 side is larger than the flow potential on the main surface on the second water permeable electrode 23 side. Therefore, when an AC voltage is applied between the first water permeable electrode 22 and the second water permeable electrode 23, the liquid is transferred from the first reservoir 12 to the second reservoir 13. Thereby, the electroosmotic flow pump 2 operates.
- the dielectric porous film 21 when the dielectric porous film 21 is applied with an alternating voltage between the first water permeable electrode 22 and the second water permeable electrode 23, the dielectric porous film 21.
- a force for moving the liquid from the first water-permeable electrode 22 side to the second water-permeable electrode 23 side is applied to the liquid inside.
- the electroosmotic flow pump 2 can be driven by an alternating voltage. Therefore, unlike the case where a DC voltage is applied to the electroosmotic pump, the liquid is electrolyzed when the electroosmotic pump 2 is driven, and the pH of the liquid is not easily changed and bubbles are not easily changed.
- Ratio of the area of the first and second permeable electrodes 22, 23 to the square of the thickness of the dielectric porous film 21 ((area of the first and second permeable electrodes 22, 23) / (dielectric)
- the thickness ( 2 ) of the porous membrane 21 is preferably greater than 100. If the ratio ((area of the first and second permeable electrodes 22 and 23) / (thickness of the dielectric porous film 21) 2 ) is too small, the efficiency of liquid feeding is deteriorated. There is no restriction for this large ratio.
- the hydrophilicity can be measured with an automatic contact angle meter (Kyowa Interface Science Co., Ltd., DM-300).
- Zeta potential A solid or liquid interface in contact with a protic solvent typified by an aqueous solution is charged except in special cases.
- the electric field due to this electric charge attracts ions (counter ions) of opposite signs from the solution side to form an ion atmosphere (electric double layer) near the surface.
- ions counter ions
- a diffusion electric double layer is present.
- the zeta potential is a potential at a “sliding surface” (also referred to as a shear surface) at the boundary between the Stern layer and the diffusion electric double layer.
- the zeta potential on the surface of the membrane can be measured by, for example, a membrane zeta potential measurement device (Otsuka Electronics Co., Ltd. ELSZ-1).
- the zeta potential in the pores can be measured by, for example, a solid zeta potential measuring device (Anton Paar Japan, SurPASS).
- Streaming potential can be measured with a solid zeta potential measuring device (Anton Paar Japan, SurPASS).
- the electroosmotic flow pump of this invention operate
- the electroosmotic pump of the present invention operates not only when an AC voltage is applied but also when a DC voltage is applied.
- FIG. 3 is a schematic cross-sectional view of a part of the liquid feeding film in the second embodiment.
- the electroosmotic pump according to the present embodiment is different from the electroosmotic flow pump according to the first embodiment in that the first water permeable electrode 22 has a hydrophilic layer 22a on the surface layer opposite to the dielectric porous membrane 21. Different from pump 2.
- the liquid feeding performance can be improved by providing the hydrophilic layer 22a.
- the hydrophilic layer 22a can be formed, for example, by performing a surface treatment with a self-assembling reagent capable of gold-thiol bonding when the first permeable electrode 22 contains gold.
- the self-assembling reagent preferably used is a molecule having a main chain including one terminal constituted by a sulfur atom and another terminal constituted by a hydrophilic group.
- a self-assembling reagent for example, HS- (CH 2 ) n —COOH (1) HOOC- (CH 2) n -S- S- (CH 2) n-COOH .
- FIG. 4 shows a schematic diagram of the hydrophilic layer 22a formed using the above-described self-assembling reagent (specifically, 1,1-mercaptodecanoic acid).
- degreasing treatment supercritical CO 2 cleaning, plasma treatment, corona discharge treatment, and the like may be additionally performed before the hydrophilic treatment with the self-assembling reagent.
- FIG. 5 is a schematic cross-sectional view of a part of the liquid feeding film in the third embodiment.
- the dielectric porous film 21 includes a first dielectric porous film 21A and a second dielectric porous film 21B.
- the first dielectric porous film 21A and the second dielectric porous film 21B are laminated.
- the first dielectric porous film 21A is located on the first water permeable electrode 22 side, and the second dielectric porous film 21B is located on the second water permeable electrode 23 side.
- the first dielectric porous film 21A is made of a material having higher hydrophilicity than the second dielectric porous film 21B.
- the hydrophilicity of the surface of the dielectric porous membrane 21 on the first water permeable electrode 22 side is higher than the hydrophilicity of the surface on the second water permeable electrode 23 side. Therefore, the electroosmotic pump of this embodiment also operates by applying an alternating voltage.
- the ratio between the thickness of the first dielectric porous film 21A and the thickness of the second dielectric porous film 21B is preferably 1: 100 to 100: 1, and more preferably 1:10 to 10: 1.
- Example 1 An electroosmotic pump having a configuration substantially similar to that of the electroosmotic pump 2 according to the first embodiment was produced in the following manner.
- a 20 nm thick gold film using a magnetron sputtering apparatus (vacuum device, MSP-1S) on both sides of a track etched film (Millipore, isopore membrane filters HTTP04700) having a thickness of 20 ⁇ m and an average pore diameter of 400 nm was deposited to form a liquid delivery film.
- MSP-1S magnetron sputtering apparatus
- MSP-1S magnetron sputtering apparatus
- a track etched film Millipore, isopore membrane filters HTTP04700
- the first and second permeable electrodes made of gold were connected to an AC power source via a conductive rubber electrode.
- the distance between the first water permeable electrode and the second water permeable electrode was 20 ⁇ m, which is equal to the thickness of the track etched film.
- FIG. 6 shows a
- the zeta potential of the surface of the track-etched film was measured using a film zeta potential measuring device (Otsuka Electronics ELSZ-1). Specifically, the velocity of electroosmotic flow induced by applying an electric field in parallel to the track-etched film was observed as the motion velocity of polystyrene latex (500 nm) that was not charged by modification of hydroxypropylcellulose. The zeta potential was measured from the movement speed. As the liquid, a 10 mM NaCl aqueous solution was used. The results are shown in Table 1 below.
- the zeta potential in the pores of the track-etched membrane was measured by the streaming potential method using a solid zeta potential measuring device (Anton Paar Japan, SurPASS).
- a solid zeta potential measuring device Anton Paar Japan, SurPASS.
- the zeta potential calculated from the flow potential from the first permeable electrode side to the second permeable electrode side is ⁇ 36.01 mV
- the zeta potential calculated from the flow potential from the second permeable electrode side to the first permeable electrode side was ⁇ 40.11 mV.
- the zeta potential inside the pores was much lower than the zeta potential on the membrane surface.
- bubbles were not substantially generated even when the AC voltage was continuously applied for 10 minutes.
- Example 2 The electroosmotic flow was the same as in Example 1 except that the surface of the first water permeable electrode opposite to the dielectric porous membrane was treated with 1,1-mercaptodecanoic acid to form a hydrophilic layer. A pump was made.
- Example 3 An electroosmotic pump was produced in the same manner as in Example 1 except that the surface of the first porous electrode on the dielectric porous membrane side was treated with 1,1-mercaptodecanoic acid to form a hydrophilic layer. did.
- the liquid feeding ability can be improved by forming a hydrophilic layer on the surface of the first water permeable electrode opposite to the dielectric porous film.
- Example 4 A liquid prepared by dissolving a pH indicator in deionized water was supplied to the apparatus prepared in Example 1, and an AC voltage of 9.34 Vrms at 25 Hz was applied between the first and second permeable electrodes for 15 minutes. Then, when the color tone of the 1st and 2nd storage part was observed, the color tone of the 1st and 2nd storage part was the same as that before voltage application, pH did not change, and the gas by electrolysis did not generate
- Liquid feeding module 2 Electroosmotic flow pump 10: Fixing jig 11: Fixing jig 12: First reservoir 13: Second reservoir 14: Discharge port 20: Liquid feeding membrane 21: Dielectric porous Membrane 21A: first dielectric porous membrane 21B: second dielectric porous membrane 21a: hydrophilic layer 22: first water permeable electrode 22a: hydrophilic layer 23: second water permeable electrode 30: liquid reservoir 40: AC power supply
Abstract
Description
図1は、本実施形態に係る電気浸透流ポンプの模式的断面図である。図2は、本実施形態における送液膜の一部分の模式的断面図である。 (First embodiment)
FIG. 1 is a schematic cross-sectional view of an electroosmotic flow pump according to the present embodiment. FIG. 2 is a schematic cross-sectional view of a part of the liquid feeding film in the present embodiment.
図3は、第2の実施形態における送液膜の一部分の模式的断面図である。 (Second Embodiment)
FIG. 3 is a schematic cross-sectional view of a part of the liquid feeding film in the second embodiment.
HS-(CH2)n-COOH ……… (1)
HOOC-(CH2)n-S-S-(CH2)n-COOH ……… (2)
HS-(CH2)n-OH ……… (3)
HS-(CH2)n-(OCH2-CH2)6-(CH2)n-OCH2-COOH ……… (4)
HS-(CH2)n-NH3Cl ……… (5)
HS-(CH2)n-(OCH2-CH2)6-NH3Cl ……… (6)
などが挙げられる。 The
HS- (CH 2 ) n —COOH (1)
HOOC- (CH 2) n -S- S- (CH 2) n-COOH ......... (2)
HS- (CH 2 ) n —OH (3)
HS— (CH 2 ) n — (OCH 2 —CH 2 ) 6 — (CH 2 ) n —OCH 2 —COOH (4)
HS- (CH 2 ) n —NH 3 Cl (5)
HS— (CH 2 ) n — (OCH 2 —CH 2 ) 6 —NH 3 Cl (6)
Etc.
図5は、第3の実施形態における送液膜の一部分の模式的断面図である。図5に示されるように、本実施形態では、誘電体多孔質膜21は、第1の誘電体多孔質膜21Aと、第2の誘電体多孔質膜21Bとを備えている。第1の誘電体多孔質膜21Aと、第2の誘電体多孔質膜21Bとは積層されている。第1の誘電体多孔質膜21Aが第1の透水性電極22側に位置しており、第2の誘電体多孔質膜21Bが第2の透水性電極23側に位置している。第1の誘電体多孔質膜21Aは、第2の誘電体多孔質膜21Bよりも親水性が高い材料により構成されている。このため、本実施形態においても、誘電体多孔質膜21の第1の透水性電極22側の表面の親水性が、第2の透水性電極23側の表面の親水性よりも高い。従って、本実施形態の電気浸透流ポンプも、交流電圧を印加することにより作動する。 (Third embodiment)
FIG. 5 is a schematic cross-sectional view of a part of the liquid feeding film in the third embodiment. As shown in FIG. 5, in the present embodiment, the dielectric
以下の要領で、第1の実施形態に係る電気浸透流ポンプ2と実質的に同様の構成を有する電気浸透流ポンプを作製した。厚さが20μmであり、平均孔径が400nmであるトラックエッチド膜(Millipore、isopore membrane filters HTTP04700)の両面にマグネトロンスパッタ装置(株式会社真空デバイス、MSP-1S)を用いて厚さ20nmの金膜を成膜させることにより、送液膜を形成した。このとき、膜の表裏は電気的に絶縁されていることを確認した。金からなる第1及び第2の透水性電極には、導電性ラバー電極を介して交流電源に接続した。第1の透水性電極と第2の透水性電極との間の距離は、トラックエッチド膜の厚みと等しく、20μmであった。図6に、実施例1において使用したトラックエッチド膜の破壊断面写真を示す。 Example 1
An electroosmotic pump having a configuration substantially similar to that of the
第1の透水性電極側から第2の透水性電極側への流動電位から計算されたゼータ電位は、-36.01mVであり、
第2の透水性電極側から第1の透水性電極側への流動電位から計算されたゼータ電位は、-40.11mVであった。細孔内部のゼータ電位は、膜表面のゼータ電位よりずっと低かった。 The zeta potential in the pores of the track-etched membrane was measured by the streaming potential method using a solid zeta potential measuring device (Anton Paar Japan, SurPASS). As a result of calculating the zeta potential from the streaming potential generated by the application of water pressure,
The zeta potential calculated from the flow potential from the first permeable electrode side to the second permeable electrode side is −36.01 mV,
The zeta potential calculated from the flow potential from the second permeable electrode side to the first permeable electrode side was −40.11 mV. The zeta potential inside the pores was much lower than the zeta potential on the membrane surface.
第1の透水性電極の誘電体多孔質膜とは反対側の表面を1,1-メルカプトウデカン酸により処理し、親水層を形成したこと以外は、実施例1と同様にして電気浸透流ポンプを作製した。 (Experimental example 2)
The electroosmotic flow was the same as in Example 1 except that the surface of the first water permeable electrode opposite to the dielectric porous membrane was treated with 1,1-mercaptodecanoic acid to form a hydrophilic layer. A pump was made.
第1の透水性電極の誘電体多孔質膜側の表面を1,1-メルカプトウデカン酸により処理し、親水層を形成したこと以外は、実施例1と同様にして電気浸透流ポンプを作製した。 (Experimental example 3)
An electroosmotic pump was produced in the same manner as in Example 1 except that the surface of the first porous electrode on the dielectric porous membrane side was treated with 1,1-mercaptodecanoic acid to form a hydrophilic layer. did.
実施例1において作製した装置に、脱イオン水にpH指示薬を溶かした液体を供給し、第1及び第2の透水性電極間に15分間、25Hzで9.34Vrmsの交流電圧を印加した。その後、第1及び第2の貯留部の色調を観察したところ、第1及び第2の貯留部の色調は、電圧印加前と同様でpHは変化せず、電気分解によるガスは発生しなかった。また、溶媒として0.9質量%のNaCl水溶液を用いた場合も第1及び第2の貯留部はpH変化を示さず、電気分解によるガスは発生しなかった。 Example 4
A liquid prepared by dissolving a pH indicator in deionized water was supplied to the apparatus prepared in Example 1, and an AC voltage of 9.34 Vrms at 25 Hz was applied between the first and second permeable electrodes for 15 minutes. Then, when the color tone of the 1st and 2nd storage part was observed, the color tone of the 1st and 2nd storage part was the same as that before voltage application, pH did not change, and the gas by electrolysis did not generate | occur | produce. . In addition, even when a 0.9 mass% NaCl aqueous solution was used as the solvent, the first and second reservoirs did not show pH change, and no gas was generated due to electrolysis.
2: 電気浸透流ポンプ
10:固定治具
11:固定治具
12:第1の貯留部
13:第2の貯留部
14:排出口
20:送液膜
21:誘電体多孔質膜
21A:第1の誘電体多孔質膜
21B:第2の誘電体多孔質膜
21a:親水層
22:第1の透水性電極
22a:親水層
23:第2の透水性電極
30:液体貯留槽
40:交流電源
1: Liquid feeding module 2: Electroosmotic flow pump 10: Fixing jig 11: Fixing jig 12: First reservoir 13: Second reservoir 14: Discharge port 20: Liquid feeding membrane 21: Dielectric
Claims (12)
- 誘電体多孔質膜と、
前記誘電体多孔質膜の一方側に配された第1の透水性電極と、
前記誘電体多孔質膜の他方側に配された第2の透水性電極と、
を備え、
前記誘電体多孔質膜の前記第1の透水性電極側の主面の親水性と、前記第2の透水性電極側の主面の親水性とが相互に異なる、電気浸透流ポンプ。 A dielectric porous membrane;
A first water permeable electrode disposed on one side of the dielectric porous membrane;
A second water permeable electrode disposed on the other side of the dielectric porous membrane;
With
The electroosmotic pump, wherein the hydrophilic property of the main surface of the dielectric porous membrane on the first permeable electrode side and the hydrophilic property of the main surface of the second permeable electrode side are different from each other. - 前記誘電体多孔質膜は、一主面に親水層を有する、請求項1に記載の電気浸透流ポンプ。 2. The electroosmotic pump according to claim 1, wherein the dielectric porous film has a hydrophilic layer on one main surface.
- 誘電体多孔質膜と、
前記誘電体多孔質膜の一方側に配された第1の透水性電極と、
前記誘電体多孔質膜の他方側に配された第2の透水性電極と、
を備え、
前記誘電体多孔質膜の一方面のゼータ電位と、他方面のゼータ電位とが相互に異なるか、または前記誘電体多孔質膜の一方面の流動電位と、他方面の流動電位とが相互に異なる、電気浸透流ポンプ。 A dielectric porous membrane;
A first water permeable electrode disposed on one side of the dielectric porous membrane;
A second water permeable electrode disposed on the other side of the dielectric porous membrane;
With
The zeta potential on one side of the dielectric porous membrane is different from the zeta potential on the other side, or the streaming potential on one side of the dielectric porous membrane is different from the streaming potential on the other side. Different, electroosmotic flow pump. - 誘電体多孔質膜と、
前記誘電体多孔質膜の一方側に配された第1の透水性電極と、
前記誘電体多孔質膜の他方側に配された第2の透水性電極と、
を備え、
前記誘電体多孔質膜は、前記第1の透水性電極と前記第2の透水性電極との間に交流電圧が印加されたときに前記誘電体多孔質膜内の液体に、前記第1の透水性電極側と前記第2の透水性電極側の一方から他方へ選択的にに移動させる力が付与されるように構成されている、電気浸透流ポンプ。 A dielectric porous membrane;
A first water permeable electrode disposed on one side of the dielectric porous membrane;
A second water permeable electrode disposed on the other side of the dielectric porous membrane;
With
The dielectric porous film is formed in the liquid in the dielectric porous film when the AC voltage is applied between the first water permeable electrode and the second water permeable electrode. An electroosmotic flow pump configured to be provided with a force to selectively move from one of the permeable electrode side and the second permeable electrode side to the other. - 前記誘電体多孔質膜は、積層された第1の誘電体多孔質膜及び第2の誘電体多孔質膜を含み、
前記一主面が前記第1の誘電体多孔質膜により構成されており、
前記他主面が前記第2の誘電体多孔質膜により構成されている、請求項1~4のいずれか一項に記載の電気浸透流ポンプ。 The dielectric porous film includes a laminated first dielectric porous film and second dielectric porous film,
The one principal surface is constituted by the first dielectric porous film;
The electroosmotic pump according to any one of claims 1 to 4, wherein the other main surface is constituted by the second dielectric porous film. - 前記第1の透水性電極と前記第2の透水性電極との間に交流電圧を印加する電源をさらに備え、
前記電源は、1MHz以下の周波数の交流電圧を印加する、請求項1~5のいずれか一項に記載の電気浸透流ポンプ。 A power source for applying an alternating voltage between the first permeable electrode and the second permeable electrode;
The electroosmotic pump according to any one of claims 1 to 5, wherein the power source applies an AC voltage having a frequency of 1 MHz or less. - 前記誘電体多孔質膜の厚みが5μm~100μmの範囲内にある、請求項1~6のいずれか一項に記載の電気浸透流ポンプ。 The electroosmotic pump according to any one of claims 1 to 6, wherein the thickness of the dielectric porous film is in the range of 5 to 100 µm.
- 前記誘電体多孔質膜の厚さの自乗に対する、前記透水性電極の面積の比((前記透水性電極の面積)/(前記誘電体多孔質膜の厚さ)2)が100より大きい、請求項1~7のいずれか一項に記載の電気浸透流ポンプ。 The ratio of the area of the water permeable electrode to the square of the thickness of the dielectric porous film ((area of the water permeable electrode) / (thickness of the dielectric porous film) 2 ) is greater than 100. Item 8. The electroosmotic pump according to any one of Items 1 to 7.
- 前記誘電体多孔質膜における平均孔径が10nm~50μmの範囲内にある、請求項1~8のいずれか一項に記載の電気浸透流ポンプ。 The electroosmotic pump according to any one of claims 1 to 8, wherein an average pore diameter in the dielectric porous membrane is in a range of 10 nm to 50 µm.
- 前記第1及び第2の透水性電極は、それぞれ、厚み方向に貫通する貫通孔を有する、請求項1~9のいずれか一項に記載の電気浸透流ポンプ。 The electroosmotic pump according to any one of claims 1 to 9, wherein each of the first and second permeable electrodes has a through hole penetrating in a thickness direction.
- 前記誘電体多孔質膜は、厚み方向に貫通する貫通孔を有する、請求項1~10のいずれか一項に記載の電気浸透流ポンプ。 The electroosmotic pump according to any one of claims 1 to 10, wherein the dielectric porous film has a through-hole penetrating in a thickness direction.
- 前記誘電体多孔質膜の前記第1の透水性電極側の主面の親水性が、前記第2の透水性電極側の主面の親水性よりも高く、
前記第1の透水性電極は、前記誘電体多孔質膜とは反対側の表層に親水層を有する、請求項1~11のいずれか一項に記載の電気浸透流ポンプ。
The hydrophilicity of the main surface of the dielectric porous membrane on the first water permeable electrode side is higher than the hydrophilicity of the main surface of the second water permeable electrode side,
The electroosmotic pump according to any one of claims 1 to 11, wherein the first water-permeable electrode has a hydrophilic layer on a surface layer opposite to the dielectric porous membrane.
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JP2014536812A JP6166268B2 (en) | 2013-10-22 | 2013-10-22 | Electroosmotic pump |
US14/390,543 US20160252082A1 (en) | 2013-10-22 | 2013-10-22 | Electroosmotic pump |
US15/655,100 US20170335836A1 (en) | 2013-10-22 | 2017-07-20 | Electroosmotic pump |
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KR102006908B1 (en) * | 2016-06-28 | 2019-08-02 | 이오플로우(주) | Electroosmotic pump and system for pumping of fluid comprising thereof |
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US20170335836A1 (en) | 2017-11-23 |
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