WO2015043049A1

WO2015043049A1 - Multifunctional medical analyser

Info

Publication number: WO2015043049A1
Application number: PCT/CN2013/087852
Authority: WO
Inventors: 周强; 朱建波; 宋成桥; 曹宁; 张陆军; 徐新
Original assignee: 江苏英诺华医疗技术有限公司
Priority date: 2013-09-30
Filing date: 2013-11-26
Publication date: 2015-04-02
Also published as: CN203595667U

Abstract

Disclosed is a multifunctional medical analyser, comprising a detection unit (7), a control and data processing unit and a display unit, wherein the detection unit (7) comprises a light source (1), a monochromator (2), a transmitted light inlet (3), a scattered light inlet (4), a detector port (5) and a detection bit (6); the light source (1) is connected to the monochromator (2), and the monochromator (2) is connected to the transmitted light inlet (3); the detection bit (6) is a detection bit having a sealed bottom and an open top, and the transmitted light inlet (3), the scattered light inlet (4) and the detector port (5) are mounted on the sides of the detection bit, respectively, wherein the transmitted light inlet (3) and the detector port (5) are mounted at opposite positions, and the scattered light inlet (4) is mounted on the other side. The multifunctional medical analyser further comprises an adapter cooperating with the detection bit, so that the instrument, which was originally only suitable for the detection of a circular cup, can be suitable for the detection of a square or other polygonal detection cups, i.e. it can be realized that detection cups with different sizes and different shapes can be used in the same instrument, making detection more flexible and convenient.

Description

Multifunctional medical analyzer

Technical field

The utility model belongs to the field of clinical medical examination, and particularly relates to a multifunctional medical analyzer with biochemical detection, coagulation detection and specific protein detection.

Background technique

The biochemical analyzer is designed according to the principle of Rambobeel's law to detect the amount of light absorbed by a specific wavelength (corresponding to the absorption peak of the analyte) when the transmitted light of a specific wavelength passes through the sample to be tested. Alternatively, the content or enzyme activity in the test sample is obtained by calculation against a known standard test result. Therefore, the detected optical signal is transmitted light of multiple wavelengths.

When visible light is transmitted (irradiated) in a liquid, the phenomenon that light is emitted all around due to the non-uniformity of the medium is the scattering of light. In some clinical medical testing programs, the use of scattered light detection has the advantage of obtaining more accurate and stable detection results or a wider range of detection. Existing hemagglutination analyzers and specific protein analyzers mainly use scattered light for detection. The blood coagulation function test detects and determines the blood coagulation function indicators of plasma from the time when the plasma is added to the blood coagulation function detection reagent to the time required for the change of the scattered light when the liquid plasma is converted into a jelly-like solidification. Specific protein detection is mainly achieved by changing the scattered light or the transmitted light caused by the immune complex formed by the specific protein and the corresponding antibody or antigen, but using scattered light detection is more sensitive and linear. Although the specific protein analyzer and the hemagglutination analyzer mainly use scattered light, the detection mode and the detection end point are different. For example, the coagulation function detection requires strict and accurate recording of the accurate contact time of the sample and the reagent, and The reagents are thoroughly mixed in the shortest time of contact with the sample to ensure accurate detection results. Therefore, the corresponding structures of the two instrument detection components are also different. In addition, the wavelengths used in the various methods are also different, and the ratio of the sample to the reagent is also greatly different. For the above reasons, biochemical tests, coagulation tests, and specific protein tests are currently performed on separate specialized instruments. Utility model content

The object of the present invention is to provide a multi-functional medical analyzer with biochemical detection, coagulation detection, and specific protein detection.

The technical solution for achieving the object of the present invention is:

A multifunctional medical analyzer includes a detecting unit, a control and data processing unit and a display unit, the detecting unit comprising a light source, a monochromator transmitted light inlet, a scattered light inlet, a detector port and a detection bit; Single The color devices are connected, the monochromator is connected to the light-transmitting inlet, and the detecting position is a detecting position of the bottom sealing top opening, and the transmitting light inlet, the scattered light inlet and the detector port are respectively arranged on the side of the detecting position, wherein the transmitting light inlet The detector port is mounted in a relative position, and the scattered light inlet is mounted on the other side.

The utility model relates to a multifunctional medical analyzer, wherein the detection position is a polygon detection position of a bottom seal top opening, and one or more transmitted light inlets, one and one or more scattered light inlets are respectively arranged on a peripheral side of the detection position. And one or more detector ports, wherein the transmitted light inlet and the detector port are mounted at opposite positions, and the scattered light inlet is mounted on the other two sides.

A preferred embodiment of the above-mentioned multifunctional medical analyzer: the detection position is a square detection position of the top opening of the bottom seal, and one detector port, one transmitted light inlet and one on the front, left, and right sides of the detection position respectively Or two scattered light entrances, wherein the transmitted light inlet is mounted in a relative position with the detector port, and the scattered light inlet is mounted on the other two sides.

A multifunctional medical analyzer, wherein the detection position is a circular detection position of a bottom seal top opening, and one or more detector ports, one and one or more transmitted light are respectively arranged on a peripheral side of the detection position. Inlet and one or more scattered light inlets, wherein the transmitted light inlet and the detector port are mounted at opposite positions, the scattered light inlet is mounted on the other two sides, and the central axis of the scattered light inlet is 20° to 160 from the central axis of the detector port ° Angle.

Preferably, the multi-function medical analyzer of the above-mentioned one is: the detection position is a circular detection position of the top opening of the bottom seal, and one detector port, one transmitted light inlet and four are respectively arranged on the peripheral side of the detection position. The light-scattering inlet, wherein the transmitted light inlet and the detector port are mounted at opposite positions, the scattered light inlet is mounted on the other side, and the central axis of the scattered light inlet is at an angle of 45° to 145° with respect to the central axis of the detector port.

Preferably, the above-mentioned multifunctional medical analyzer 2: the detection position is a circular detection position of the top opening of the bottom seal, and two detector ports, two transmitted light entrances and two are respectively arranged on the peripheral side of the detection position. The light-scattering inlet, wherein the transmitted light inlet and the detector port are mounted at opposite positions, the scattered light inlet is mounted on the other side, and the central axis of the scattered light inlet is at an angle of 45° to 145° with respect to the central axis of the detector port.

A multifunctional medical analyzer, the detecting unit further comprising a heating device mounted on the inner side of the side wall around the detecting position, near the bottom position.

A multifunctional medical analyzer, the detecting unit further comprising a stirring device, the stirring device comprising a magnetic bar, a magnet and a motor, the stirring device being installed at the bottom of the detecting position.

An adapter for use in a detection position of a multi-function medical analyzer, the adapter being a cylindrical structure with a top opening, a bottom seal or an opening, the outer contour of the adapter and the shape of the analyzer detecting bit are matched, and the inner contour is cylindrical The structure or the interior may also be a polygonal columnar structure such as a square or a rectangle, and a circular hole is formed in the side surface, and the position of the circular hole corresponds to the transmitted light entrance, the scattered light inlet, and the detector port. Compared with the prior art, the utility model has the significant advantages that:

(1) The multifunctional medical analyzer provided by the utility model has the functions of biochemical detection, coagulation detection and specific protein detection, and the instrument is also equipped with a constant temperature and automatic stirring device, so that it has all the previous biochemical analysis and coagulation function analysis. Detection function;

(2) The multi-function medical analyzer has a plurality of detection mode program selections, and can integrate different detection procedure conditions such as biochemical detection and blood coagulation detection into one controller, and perform detection as needed;

(3) The multi-function medical analyzer, the analyzer's scattered light entrance of the circular detection position can be installed at different positions, and the corresponding scattering light source can select different wavelengths and different angles to better meet the needs of different sample detection;

(4) The multi-function medical analyzer also includes an adapter that cooperates with the detection position, so that the instrument that is only suitable for circular cup detection can be used for detection of square or other polygonal detection cups, so that different sizes can be used in the same instrument. Different shapes of test cups make the detection more flexible and convenient. The present invention will be further described in detail below with reference to the accompanying drawings.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a plan view of a detection position of a square detection unit of a medical analyzer of the present invention (1-light source, 2-monochromator, 3-transmitted light entrance, 4-scattered light inlet, 5-detector port, 6- Detection bit, 7-detection unit).

Fig. 2 is a top view of the square detector position of the medical analyzer detection unit of the present invention, which is equipped with a detection cup adapter suitable for a circular detection cup.

3 is a schematic view of a circular detection position of the medical analyzer of the present invention.

4 is a schematic view of a circular detection position of the medical analyzer of the present invention.

Figure 5 is a top plan view of a detection bit adapter of the medical analyzer of the present invention.

Figure 6 is a cross-sectional view taken along line A-A of Figure 5.

Figure 7 is a schematic view of the structure of the medical analyzer detecting position stirring device (8-detecting cup, 9-magnet, 10-magnet, 11-motor). BEST MODE FOR CARRYING OUT THE INVENTION The following embodiments will enable those skilled in the art to more fully understand the present invention. Embodiment 1 A multifunctional medical analyzer includes a detecting unit, a control and data processing unit, and a display unit, as shown in FIG. 1: The detecting unit 7 includes a light source 1, a monochromator 2, a transmitted light entrance 3, and a scattered light. The inlet 4, the detector port 5 and the detection bit 6; the light source 1 is connected to the monochromator 2, the monochromator 2 is connected to the transmitted light inlet 3, and the detection bit 6 is a square detection position of the bottom seal top opening, respectively A transmissive light inlet 3, two scattered light inlets 4 and a detector port 5 are mounted on the front, rear, left and right sides of the detection position, wherein the transmitted light inlet 3 and the detector port 5 are mounted at opposite positions, the scattered light entrance 4 installed on the other two sides. There may be only one of the scattered light entrances.

An adapter for use in the detection position of the multifunctional medical analyzer described above, as shown in FIG. 5 and FIG. 6: the adapter is a cylindrical structure with a top opening and a bottom seal, and the outer contour of the adapter cooperates with the analyzer detection position 6. The square structure has a cylindrical structure inside, and four sides have circular holes, and the positions of the circular holes correspond to the transmitted light entrance 3, the scattered light inlet 4, and the detector port 5.

When applying the instrument for biochemical detection, put a square test cup at the detection position 6, put the reagent and sample into the test cup and mix it, then the transmitted light source 1 is turned on, and the appropriate wavelength is selected by the monochromator 2, monochrome The device 2 is connected to the transmitted light entrance 3, and the transmitted light can be selected to have different wavelengths, and the detector detects the optical signal passing through the detection cup through the detector port 5. The adapter can also be placed in the detection hole first. As shown in Figure 2, the detection position can be changed from the original suitable cup detection to a round cup detection.

Embodiment 2 A multifunctional medical analyzer includes a detecting unit, a control and data processing unit, and a display unit. The detecting unit 7 includes a light source 1, a monochromator 2 transmitted light inlet 3, a scattered light inlet 4, and a detector port. 5 and detection bit 6; the detection bit 6 is a circular detection position of the bottom seal top opening, as shown in FIG. 3, one transmission light inlet 3, 4 scatterings are respectively arranged on the front and rear four sides of the detection position. a light inlet 4 and a detector port 5, wherein the transmitted light inlet 3 and the detector port 5 are mounted at opposite positions, the scattered light inlet 4 is mounted on the other side, and the central axis of the scattered light inlet is 45° and 135 with the central axis of the detector port. ° Angle. The detecting unit 7 further includes a heating device 12 mounted on the inner side of the side wall around the detecting position 6 near the bottom position.

When the instrument is used for blood coagulation (such as partial prothrombin, fibrin project, etc.), the scattered light signal is generally detected, and the 405 nm wavelength and 45° angle incident light source are selected for detection. During the test, the reagent is first added to the test cup according to the requirements of the reagent specification. The rotation of the stirring motor 11 as shown in FIG. 7 causes the magnet 10 to rotate, so that the magnetic rod 9 in the detecting cup 8 rotates and stirs the sample in the detecting cup, and the detection position is heated. Its constant temperature is 37 °C. Then, after the sample is added, the instrument starts to count, and the detector continuously detects the change of the scattered light intensity of the sample in the test cup, when the detection cup is scattered. The light intensity suddenly increases, indicating that the sample has solidified. The instrument can obtain the coagulation function test result of the sample according to the mathematical model set.

Embodiment 3 A multifunctional medical analyzer includes a detecting unit, a control and data processing unit, and a display unit. The detecting unit 7 includes a light source 1, a monochromator 2 transmitted light inlet 3, a scattered light inlet 4, and a detector port. 5 and detection bit 6; the detection bit 6 is a circular detection position of the bottom seal top opening, as shown in FIG. 3, two transmission light inlets 3 and two scatterings are respectively arranged on the front, rear, left and right sides of the detection position. Light inlet 4 and 2 detector ports 5, wherein the transmitted light inlet 3 and the detector port 5 are mounted at opposite positions, the scattered light inlet 4 is mounted on the other side, and the central axis of the two detector ports is at an angle of 90°, and the light entrance is scattered. The central axis is at an angle of 45° and 135° to the central axis of the detector port. The detecting unit 7 further includes a heating device 12 mounted on the inner side of the side wall around the detecting position 6 near the bottom position.

The instrument was used for specific protein detection (such as C-reactive protein, rheumatoid factor project, etc.), and the detection of scattered light at 670 nm, 45°, and 135° angle sources was selected. When detecting, the instrument detection position is as shown in Fig. 4. In the detection position, a scattered light incident port 4 is formed at an angle of 45° to the detector port, and the detector port is irradiated with a light signal of a wavelength of 670 nm, and the light is irradiated into the detection cup. The instrument detector port 5 can detect the scattered light generated by the light irradiated by the scattered light incident port at 60°. Simultaneously or alternately, when the 510 nm incident light is irradiated at a 135° angle to the other detector port, the other detector port can detect the scattered light formed by the 510 nm incident light irradiated by the 135° angle in the detection position. In the test, according to the reagent instructions, the reagents and samples are added to the test cup, and the necessary stirring and constant temperature are used to start the test. The intensity of the scattered light of the sample may be detected, or the change of the scattered light of the sample may be detected.

Claims

Claim

A multifunctional medical analyzer comprising a detecting unit, a control and data processing unit and a display unit, characterized in that: the detecting unit (7) comprises a light source (1), a monochromator (2), a transmitted light entrance ( 3), a scattered light inlet (4), a detector port (5) and a detection bit (6); the light source (1) is connected to the monochromator (2), the monochromator (2) and the transmitted light entrance (3) Connected, the detection bit (6) is a bottom seal top opening, and a transmitted light inlet (3), a scattered light inlet (4) and a detector port (5) are respectively arranged on the side of the detection position, wherein the transmitted light inlet (3) Install the detector port (5) in the opposite position and the diffused light inlet (4) on the other side.

The multifunctional medical analyzer according to claim 1, wherein: the detection bit (6) is a polygon detection bit of a bottom seal top opening, and one and one are respectively mounted on a peripheral side of the detection position. Above transmitted light inlet (3), 1 and more scattered light inlets (4) and 1 and more detector ports (5), wherein the transmitted light inlet (3) and the detector port (5) are mounted The relative position, the diffused light inlet (4) is mounted on the other two sides.

The multifunctional medical analyzer according to claim 2, wherein: the detection bit (6) is a square detection position of the top opening of the bottom seal, and one of the front and rear sides of the detection position is respectively mounted on the four sides. a detector port (5), a transmitted light inlet (3) and two scattered light inlets (4), wherein the transmitted light inlet (3) and the detector port (5) are mounted at opposite positions, and the scattered light inlet (4) Installed on the other two sides.

The multifunctional medical analyzer according to claim 1, wherein: the detection bit (6) is a circular detection position of a bottom seal top opening, and one and one are respectively mounted on a peripheral side of the detection position. More than one detector port (5), one and more transmitted light inlets (3) and one and more scattered light inlets (4), wherein the transmitted light inlet (3) and the detector port (5) are installed In the opposite position, the scattered light inlet (4) is mounted on the other two sides, and the center axis of the scattered light inlet is at an angle of 20° - 160° to the central axis of the detector port.

The multifunctional medical analyzer according to claim 4, wherein: the detection bit (6) is a circular detection position of the bottom seal top opening, and one detector is mounted on the peripheral side of the detection position, respectively. a port (5), a transmitted light inlet (3) and four scattered light inlets (4), wherein the transmitted light inlet (3) is mounted in a relative position with the detector port (5), and the scattered light inlet (4) is mounted On the other side, the central axis of the scattered light entrance is at an angle of 45° to 145° to the central axis of the detector port.

The multifunctional medical analyzer according to claim 4, wherein: the detection bit (6) is a circular detection position of the bottom seal top opening, and two detectors are respectively mounted on the peripheral side of the detection position. a port (5), two transmitted light inlets (3) and two scattered light inlets (4), wherein the transmitted light inlet (3) is mounted in a relative position with the detector port (5), and the scattered light inlet (4) is mounted On the other side, the central axis of the scattered light entrance is at an angle of 45° to 145° to the central axis of the detector port.

The multifunctional medical analyzer according to any one of claims 1 to 6, characterized in that the detecting unit (7) further comprises a heating device (12), the heating device (12) being mounted at the detection position (6) Inside the side walls, close to the bottom.

The multifunctional medical analyzer according to any one of claims 1 to 7, characterized in that the detecting unit further comprises a stirring device comprising a magnetic bar (9), a magnet (10) and a motor (11) , the stirring device is installed at the bottom of the detection position (6) Ministry.

9. An adapter for use in the detection position of the multifunctional medical analyzer according to claims 1-7, characterized in that the adapter is a cylindrical structure with a top opening and a bottom seal, and the outer contour of the adapter and the analyzer are detected. The position of (6) is matched with each other, the inner contour is a cylindrical or polygonal structure, and the side has a circular hole, and the position of the circular hole corresponds to the transmitted light inlet (3), the scattered light inlet (4) and the detector port (5).

10. An adapter for use in the detection position of the multifunctional medical analyzer according to claims 1-7, characterized in that the adapter is a cylindrical structure with a top opening and a bottom opening, and the outer contour of the adapter and the analyzer are detected. The position of (6) is matched with each other, the inner contour is a cylindrical or polygonal structure, and the side has a circular hole, and the position of the circular hole corresponds to the transmitted light inlet (3), the scattered light inlet (4) and the detector port (5).