WO2015024141A1 - Dispositif de stockage de produits biologiques comportant un élément d'observation - Google Patents

Dispositif de stockage de produits biologiques comportant un élément d'observation Download PDF

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Publication number
WO2015024141A1
WO2015024141A1 PCT/CN2013/000978 CN2013000978W WO2015024141A1 WO 2015024141 A1 WO2015024141 A1 WO 2015024141A1 CN 2013000978 W CN2013000978 W CN 2013000978W WO 2015024141 A1 WO2015024141 A1 WO 2015024141A1
Authority
WO
WIPO (PCT)
Prior art keywords
biological product
space
biological
input
low temperature
Prior art date
Application number
PCT/CN2013/000978
Other languages
English (en)
Chinese (zh)
Inventor
庄明熙
郑汉中
马钰欣
Original Assignee
国玺干细胞应用技术股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 国玺干细胞应用技术股份有限公司 filed Critical 国玺干细胞应用技术股份有限公司
Priority to PCT/CN2013/000978 priority Critical patent/WO2015024141A1/fr
Priority to CN201380025993.1A priority patent/CN105263817B/zh
Priority to MYPI2014702999A priority patent/MY175793A/en
Publication of WO2015024141A1 publication Critical patent/WO2015024141A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0252—Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0252—Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
    • A01N1/0257—Stationary or portable vessels generating cryogenic temperatures

Definitions

  • the present invention relates to a biological product storage device, and more particularly to a biological product storage device having an observation member. Background technique
  • stem cells are a major focus.
  • temperature has a decisive influence on the storage of biological cells or related biological products
  • the storage methods are completely closed. Space and the addition of ultra-low temperature gas to keep the storage space at a fixed temperature to keep the biological cell-related biological products effective, but also because of their special storage environment, the biological product storage device must be artificially used for biological cells. Or the storage and removal of related biological products, and the storage device lacks a light transmission design that allows the user to directly observe the inside from the outside, thereby increasing the inconvenience in use.
  • the storage method is to keep the storage space fixed in a completely enclosed space and adding ultra-low temperature gas.
  • the temperature keeps the biological cell-related biological products effective, but because of its special storage environment, the biological product storage device makes the storage device less one. Inconvenient, it is therefore an object of the present invention to provide a biological product storage device having an observation element that facilitates direct viewing of internal storage from the outside.
  • a biological product storage device with a viewing element comprising a body, a cryogenic holding device, a biological product transport device and a control module, wherein: the body comprises a low temperature storage space, an input and output space, and is formed on the body corresponding to Observation element for low temperature storage space, the low temperature storage a plurality of biological products are stored inside the space, the observation component is transparent, and the input/output interface is disposed adjacent to the input and output space; the cryogenic holding device is disposed in the body, and provides a low temperature source to the low temperature storage space to maintain the low temperature The biological product is stored in the storage space; the control module drives the biological product transport device to move the selected biological product between the cryogenic storage space and the input and output space.
  • the low temperature storage space includes a shelf corresponding to the position of the observation component, the biological product comprising a packaging structure and a plurality of biological tissue storage units placed in the containing structure, each of the biological products Positioned in the set position of the shelf; the biological product transfer device is a robot arm that picks up the biological product to move between the input and output space and the set position.
  • the low temperature storage space includes a pylon corresponding to the position of the observation component, the biological product comprising a accommodating structure and a plurality of biological storage units placed in the accommodating structure, each of the biological product hoist Hanging on the set position of the shelf;
  • the biological product transmission device is a robot arm that picks up the biological product to move between the input and output space and the set position.
  • the body includes a transmission space, and the transmission space is critically disposed in the low temperature storage space, and the biological product transportation device is movable in the transmission space, the transmission space and the low temperature storage space system Separating the pickup door, the control module controls opening the pickup door and driving the robot to transport the biological product in the low temperature storage space and the input and output space.
  • the input and output space comprises a room temperature contact door and a transmission contact door
  • the room temperature contact door and the transmission contact door are selectively opened by the control of the control module, and the control module is selected according to the selected The open room temperature contact door or the transfer contact door controls the internal environment of the output space.
  • the biological product storage device with a viewing element, wherein: the control module includes an input/output interface and a display interface disposed on the outer surface of the body, the input/output interface accepting an external input control to drive the control module to drive the biological product transmission device Transmitting the selected biological product, the display interface displays a selection result of the biological product, a state of the control system, and an internal temperature of the body; and a bottom surface of the body is fixedly coupled to the plurality of pulleys.
  • the aforementioned biological product storage device with observation elements is powered by a battery, a generator or an uninterruptible power system.
  • the observation element is a two-layer structured light-transmissive window, and the two-layer light-transmitting window of the two-layer structure is filled with an isolating fluid.
  • the observation element is a two-layer structure light-transmitting window, and the observation element includes a photographing device and a display device corresponding to the photographing of the low-temperature storage space.
  • the photographing device continuously captures the cryogenic storage space or the transporting process of the biological product, so that the display device displays the content recorded by the photographing device.
  • the containing structure is light transmissive
  • the biological tissue storage unit is a non-transparent test tube capable of filling biological tissue.
  • the biological product storage device with the observation element of the present invention can achieve considerable technical progress and practicality, and has industrial wide-ranging value, and has at least the following advantages:
  • a biological product storage device having an observation member is provided with an observation member which facilitates a user to directly observe internal storage from the outside.
  • the user can use the input/output interface to control the movement of the biological product transmission device, and take out or deposit the biological product, thereby avoiding accidents or errors that may occur in human operation.
  • the display interface displays the result of the selection of the biological product, the status of the control system, and the internal temperature of the body.
  • FIG. 1 is a perspective view of a preferred embodiment of the present invention.
  • FIG. 2 is a perspective view of an internal device in accordance with a preferred embodiment of the present invention.
  • Figure 3 is a perspective view of a region of a preferred embodiment of the present invention.
  • Figure 4 is a partial cross-sectional view of a preferred embodiment of the present invention.
  • Figure 5 is a partial enlarged view of a preferred embodiment of the present invention.
  • 6-1 1 is a schematic diagram of a biological product transmission structure according to a preferred embodiment of the present invention.
  • Figure 12 is a block diagram of a system in accordance with a preferred embodiment of the present invention.
  • FIG. 13 is a perspective view of a second preferred embodiment of the present invention.
  • 14 and 15 are schematic views showing the structure of a biological product transmission according to a second preferred embodiment of the present invention.
  • 16, 17, and 18 are schematic views of the taking action of the second preferred embodiment of the present invention.
  • Figure 19 is a schematic illustration of the components of a preferred embodiment of the present invention.
  • Body 1 1 Low temperature storage space
  • Control Module 52 Display Interface
  • FIG. 1 to FIG. 5 and FIG. 12 are a preferred embodiment of a biological product storage device with a viewing element according to the present invention, which comprises a body 10 , a cryostat 20 , a power supply 30 , and a biological product transmission device . 40 and control module 50.
  • the body 10 includes a low temperature storage space 11, an output space 1 3, an observation member 15, and the low temperature storage space 1 1 is used to store a plurality of biological products 80 to maintain the quality or utility of the biological product 80.
  • the storage or storage mode of each of the biological products 80 is not limited, and may be a horizontal arrangement, a layered arrangement, or a hanging arrangement.
  • the storage method of the biological product 80 of the embodiment is provided in the low temperature storage space 11 .
  • a shelf 111 of the layer, and a plurality of the biological products 80 are sequentially arranged on the shelf 111.
  • the shelf 111 can be configured for stacking up and down, or for horizontal spacing.
  • the input and output space 13 is disposed adjacent to the low temperature storage space 11 , and the input and output space 13 is a relay space for the biological product 80 to be transferred between the room temperature environment and the low temperature storage space 11 to ensure that the biological product 80 is in the The storage environment stability of the low temperature storage space 11.
  • the form of the biological product 80 is not limited.
  • the biological product 80 of the present embodiment includes a containing structure 81 and a plurality of biological storage units 83.
  • the number of the biological storage units 83 placed in each of the containing structures 81 depends on the containing structure 81 and The volume relationship of the biological storage unit 83 depends on the user's needs.
  • the containing structure 81 can be made of a light transmissive material, such as a low temperature resistant plastic, and the light transmissive material is used to allow the user to directly view the biological product 80 placed in the temperature storage space 11 .
  • the biological storage unit 83 can be a non-transparent tube, which can be filled with biological tissue, and the non-transparent tube can effectively prevent the biological tissue from being changed or damaged by light.
  • the observation element 15 is disposed on the body 10 and corresponds to the position of the low temperature storage space 11, so that an external user can observe the biological product 80 in the low temperature storage space 11 through the observation element 15.
  • the position of each shelf 1 1 1 corresponds to the viewing element 15 so that the user can directly view the specific biological product 80 on each shelf 11 (for example, the specific user of the specific user) Product 80).
  • the observation element 15 corresponds to the hanging position at which each biological product 80 is hung.
  • the observation element 15 may also be a combination of a photographing device and a display device corresponding to the photographing of the low temperature storage space 11, and the photographing device continuously captures the transport flow of the low temperature storage space 1 1 or the biological product 80, so that the display device displays The recorded process allows the user to continuously observe the specific condition of the biological product 80 stored inside the low temperature storage space 11 through the observation element 15.
  • the viewing element 15 is a two-layer structured light-transmissive window.
  • the two-layer light-transmissive window has a filling gap 153 between the two transparent layers 151.
  • the filling gap 153 can fill the insulating fluid to make the viewing element. 1 5 has a good temperature insulation effect, and the external ambient temperature is not easily transmitted into the low temperature storage space 1 1; the isolation fluid may be a gas or a liquid.
  • the main body 10 includes a transport space 17 adjacent to the low temperature storage space 11 and the input/output space 13 , and the transport space 17 is a transport channel for the biological product 80 to be transmitted to the input/output space 13 .
  • the biological product 80 is transported between the input/output space 13 and the low temperature storage space 11 via the transport space 17 by means of transport.
  • the cryostat 20 can be placed in the body 10 to provide a cryogenic fluid (eg, liquid nitrogen) to maintain a storage temperature of the cryogenic storage space 11, wherein the cryostat 20 can be controlled by the control module 50.
  • a cryogenic fluid eg, liquid nitrogen
  • the level or stability of the control controls the release of the flow of the cryogenic fluid to achieve a temperature control effect.
  • the power supply 30 is coupled to at least the control module 50 to provide the power required to operate the electrical components of the present embodiment, wherein the power supply 30 can be a mains, battery, generator, or uninterruptible power system, or a combination thereof.
  • the power supply 30 can be an uninterruptible power system that can be connected to an external mains. After the external mains supply is disconnected, the uninterruptible power system provides the power required for the continuous operation of the embodiment.
  • the transport means of the embodiment is that the biological product transport device 40 is movably disposed in the transport space 17, and the low temperature storage space 11 and the transport space 17 can be provided with a cabin.
  • the door 11 3 , the action of the biological product transport device 40 and the switch of the pickup door 113 can be controlled by the control module 50, and can be effectively controlled by controlling the opening and closing of the pickup door 1 1 3
  • the environment of the low temperature storage space 11 is maintained at a specific temperature. For example, by controlling the opening and closing times of the respective pickup doors 1 1 3, the stability of the low temperature storage space 1 1 can be maintained, and the storage quality of the biological product 80 can be maintained.
  • the biological product transport device 40a of the present embodiment is a mechanical arm having a three-axis moving function, and includes a longitudinal displacement device 42, a lateral displacement device 44, and an extracting unit. 48.
  • the longitudinal displacement device 42 moves the take-up unit 48 in the Z-axis direction, and the pick-up unit 48 is movably disposed on the lateral displacement device 44.
  • the longitudinal displacement device 42 of the embodiment is axially connected by a motor.
  • the scroll member moves the scroll member up and down on the Z-axis by controlling the motor rotation speed and steering.
  • the lateral displacement device 44 can correspond to the moving configuration of the longitudinal displacement device 42 or can achieve the effect of moving position adjustment by using a rack and a geared motor set that is movably engaged with the rack.
  • the pick-up unit 48 is disposed on the lateral displacement unit 44 to adjust the position of the pick-up unit 48 when the gear motor group is moved laterally.
  • the take-up unit 48 of the embodiment is a mechanical arm having a telescopic function, and the mechanical clip 484 can be extended to protrude in the X-axis direction.
  • the position of the mechanical clamp 484 can be adjusted to achieve the effect of transporting the biological product 80.
  • the partial shape of the mechanical jaw 484 can cooperate with the containment configuration 81 such that the containment configuration 81 can be easily held by the mechanical jaw 484 and remain stable during transport, such as the mechanical jaw.
  • the end of the 484 is formed with two protruding barbs
  • the receiving structure 81 is formed with two grooves corresponding to the outer shape at the bottom, and the groove can correspond to the barb, so that the biological product transport device 40b transports the biological product.
  • the barb of the mechanical jaw 484 can correspond to the recess of the mounting structure 81, so that the containing structure 81 is held and transported by the mechanical jaw 484 to remain stable without falling.
  • the biological product transmission device 40 is electrically connected to the power supply device 30, and the biological product transmission device 40 can also be disposed in the low temperature storage space 11, and the biological product transportation device 40b has three
  • the X-axis or Y-axis of the robot arm of the axis shift function is matched by a motor with a hook and take-up device 49.
  • the hook pick-up device 49 includes a mechanical barb 491 that expands and contracts along the Z-axis, and the mechanical barb 491 is stretched by a motor.
  • Displacement, and the loading structure 81 is formed with a lifting bar 491, and a groove is formed in the lifting bar 82.
  • the groove can be matched with the mechanical barb 491 to make the biological product transportation device. 4
  • the mechanical barbs 491 can correspond to the recesses in the configuration 81 such that the containing structure 81 is hooked by the mechanical barbs 491 and remains stable without falling.
  • the rotating robot arm 133 can be disposed in the input and output space 13 after the selected biological product 80 is transferred to the adjacent position of the output space 13
  • the rotary robot arm 133 is placed in the input/output space 13 by the hook taking device 49 to receive the biological product 80.
  • the input/output space 13 includes a room temperature contact door and a transmission contact door, and the room temperature contact door and the transmission contact door are selectively opened by the control of the control module 50, and the control module 50 contacts according to the selected room temperature.
  • the door or the transfer contact door controls the internal environment of the output into the space 13.
  • the manner of controlling the internal environment of the output into the space 13 may be that the control module 50 injects air or a specific amount of liquid nitrogen under the specific opening or closing condition of the room temperature contact door and the transmission contact door; for example, The external environment is placed in the biological product 80 after the input and output space 1 3, and the required content of liquid nitrogen is injected to cool down, and the low temperature storage space 11 and/or the transportation space can be The environment is close to each other, and the stability of the transport space 17 is increased by the low temperature storage space 1 1 .
  • the control module 50 includes an input/output interface 54, a central control unit 56, and a display interface 52.
  • the central control unit 56 controls the cryogenic holding device 20, the low temperature storage space 1 1 and the biological product, respectively.
  • the transmission device 40 and the input/output space 13 are provided.
  • the central control unit 56 controls the cryogenic holding device 20 to maintain the temperature between the cryogenic storage space 1 1 or each of the pickup doors 1 1 3, so that the temperature of the biological product 80 in the transport can be gradually increased or decreased to the target space.
  • the central control unit 56 controls the storage position of the biological product 80 on each of the shelves 1 1 1 in the low temperature storage space 1 1 , after the user selects a certain biological product 80 by the input/output interface 54
  • the central control unit 56 controls the robotic arm in the biological product delivery device 40 to select the correct bio-product 80 and transport it to the input-input space 13.
  • the input/output interface 54 can be disposed adjacent to the input/output space 13 .
  • the user can select or deposit a specific bio-product 80 from the input/output interface 54 after the user operates the input/output interface 54.
  • the input/output interface 54 outputs an operation signal to the central control unit 56.
  • the central control unit 56 After receiving the operation signal, the central control unit 56 performs corresponding control, deposits or retrieves the biological product 80, and presents the result to the opposite
  • the interface 52 is displayed; in addition, the user can also know the number, number, storage time, and temperature of the inside of the body 10 in the cryostat 20 from the display interface 52.
  • a plurality of pulleys 19 can be mounted on the bottom surface of the body 10 , and the plurality of pulleys 19 can facilitate the movement of the body 10 to increase the convenience of use.
  • a biological product storage device having an observation member is provided with an observation member which facilitates a user to directly observe internal storage from the outside.
  • the user can use the input and output interface to control the action of the biological product transmission device, and take out or deposit the biological product, in addition to eliminating accidents or errors that may occur in human operation, and more efficiently selecting a specific biological product. Avoid the risk of choosing the wrong one.
  • the display interface displays the result of the selection of the biological product, the status of the control system, and the internal temperature of the body.
  • the biological product storage device with the observation element of the present invention has high mobility, and the user can move lightly without affecting the storage of the biological product.

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dentistry (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Warehouses Or Storage Devices (AREA)
  • Instructional Devices (AREA)

Abstract

La présente invention porte sur un dispositif de stockage de produits biologiques comportant un élément d'observation. Le dispositif de stockage de produits biologiques comprend un corps, un appareil de maintien à basse température, une alimentation, un appareil de transport de produits biologiques et un module de commande. Le corps comprend un espace de stockage à basse température, un espace d'entrée de sortie, et un élément d'observation disposé sur le corps et correspondant à l'espace de stockage à basse température. De multiples produits biologiques sont stockés dans l'espace de stockage à basse température. L'élément d'observation peut permettre à de la lumière de le traverser. Un orifice d'entrée de sortie est disposé de façon adjacente dans l'espace d'entrée de sortie. L'appareil de maintien à basse température est disposé dans le corps. L'appareil de maintien à basse température procure une source de basse température à l'espace de stockage à basse température, et maintient efficaces les produits biologiques stockés dans l'espace de stockage à basse température. Le module de commande entraîne l'appareil de transport de produits biologiques pour déplacer les produits biologiques sélectionnés entre l'espace de stockage à basse température et l'espace d'entrée et de sortie.
PCT/CN2013/000978 2013-08-22 2013-08-22 Dispositif de stockage de produits biologiques comportant un élément d'observation WO2015024141A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PCT/CN2013/000978 WO2015024141A1 (fr) 2013-08-22 2013-08-22 Dispositif de stockage de produits biologiques comportant un élément d'observation
CN201380025993.1A CN105263817B (zh) 2013-08-22 2013-08-22 具观察元件的生物产品储藏设备
MYPI2014702999A MY175793A (en) 2013-08-22 2013-08-22 Biological product storage equipment having an observation element

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2013/000978 WO2015024141A1 (fr) 2013-08-22 2013-08-22 Dispositif de stockage de produits biologiques comportant un élément d'observation

Publications (1)

Publication Number Publication Date
WO2015024141A1 true WO2015024141A1 (fr) 2015-02-26

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PCT/CN2013/000978 WO2015024141A1 (fr) 2013-08-22 2013-08-22 Dispositif de stockage de produits biologiques comportant un élément d'observation

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CN (1) CN105263817B (fr)
WO (1) WO2015024141A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101793458A (zh) * 2010-04-02 2010-08-04 中山大学 具有dsc及微结构观察功能的真空冷冻干燥装置
CN201845506U (zh) * 2010-01-14 2011-05-25 上海海洋大学 食品低温物流用货架寿命指示装置
CN202944697U (zh) * 2012-11-23 2013-05-22 朱秀丽 一种疫苗保存装置

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CN2124888U (zh) * 1990-10-29 1992-12-16 陈宗如 具有制冷制热功能的恒温槽
US5638686A (en) * 1995-02-23 1997-06-17 Thermogenesis Corporation Method and apparatus for cryogenic storage of thermolabile products
ITBO20020607A1 (it) * 2002-09-26 2004-03-27 Cryorobotics Sistema automatico per la conservazione a temperatura
CN102133969A (zh) * 2011-03-07 2011-07-27 山东博科生物产业有限公司 生物安全储药箱
CN102730318A (zh) * 2011-03-29 2012-10-17 金良珍 一种保温箱

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN201845506U (zh) * 2010-01-14 2011-05-25 上海海洋大学 食品低温物流用货架寿命指示装置
CN101793458A (zh) * 2010-04-02 2010-08-04 中山大学 具有dsc及微结构观察功能的真空冷冻干燥装置
CN202944697U (zh) * 2012-11-23 2013-05-22 朱秀丽 一种疫苗保存装置

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CN105263817B (zh) 2017-04-12

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