WO2015019071A1 - Dispositifs d'injection - Google Patents

Dispositifs d'injection Download PDF

Info

Publication number
WO2015019071A1
WO2015019071A1 PCT/GB2014/052391 GB2014052391W WO2015019071A1 WO 2015019071 A1 WO2015019071 A1 WO 2015019071A1 GB 2014052391 W GB2014052391 W GB 2014052391W WO 2015019071 A1 WO2015019071 A1 WO 2015019071A1
Authority
WO
WIPO (PCT)
Prior art keywords
flexible member
injection
injector
plunger
elongate
Prior art date
Application number
PCT/GB2014/052391
Other languages
English (en)
Inventor
Toby Cowe
Original Assignee
Owen Mumford Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Owen Mumford Limited filed Critical Owen Mumford Limited
Priority to EP14750796.6A priority Critical patent/EP3030288B1/fr
Priority to CN201480044256.0A priority patent/CN105451792B/zh
Priority to JP2016532732A priority patent/JP2016528983A/ja
Priority to US14/910,155 priority patent/US10183121B2/en
Publication of WO2015019071A1 publication Critical patent/WO2015019071A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/3157—Means providing feedback signals when administration is completed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod

Definitions

  • This invention relates to injection devices including an activation indicator and in particular, but not exclusively to an auto injector device.
  • Injection devices are used for the convenient administration of medicaments.
  • auto injectors may be used for providing a single metered dose of a medicament, such as Epinephrine, in an emergency or for providing regular metered doses of a medicament, such as insulin.
  • injection devices with an activation indicator which provides one or more of a visual, tactile or audible indication of the firing of the injector actuation mechanism.
  • an activation indicator which provides one or more of a visual, tactile or audible indication of the firing of the injector actuation mechanism.
  • injection Complete is used to refer to a condition in which a satisfactory delivery of the medicament has been achieved.
  • auto injectors it is desirable for auto injectors to be of a compact form so that they can be carried around and used unobtrusively (typically such auto injectors are provided in a pen injector type form). Further compact injectors may be simple to manufacture, assemble and use with consequent savings in manufacturing and assembly costs, and a lower environmental impact. Accordingly, any activation indicator provided within the injector must be of compact form and not significantly impact the overall size of the injection device.
  • Embodiments of the present invention are intended to address at least some of the abovementioned problems.
  • this invention provides an injection device comprising:
  • a plunger arranged for expressing a medicament from a syringe
  • an actuation mechanism arranged in use to move the plunger between a first rearward position and a second forward position to express a dose from the syringe; wherein the injector device further comprises
  • an injection activation sensor comprising
  • an elongate flexible member having a first end connected to the plunger or actuation mechanism such that actuation motion of the injection device acts to move the elongate flexible member relative to the housing and
  • the injection activation sensor may be an injection completion sensor and as such the movement may trigger a response to the injection completion.
  • the injection activation sensor may, for example, trigger a further sequence within the injection device.
  • the sensor may trigger the retraction of a syringe after an injection.
  • the sensor could be used to trigger the movement or release of a needle shroud after injection.
  • embodiments of the invention may allow the subsequent sequential action to be triggered by the actual satisfactory delivery of the medicament (since the sensor may for example sense movement of the plunger) rather than simply by the movement of the actuation device.
  • the response to the injection may be an indication to the user.
  • the injection activation sensor may be an injection activation indicator.
  • the response to the injection may be an injection complete indication.
  • the invention comprises an injection activation indicator for an injector comprising
  • an elongate flexible member having a first end arranged to be connected in use to a plunger or actuation mechanism of the injector such that actuation motion of the injection device acts to move the elongate flexible member and said movement of the elongate member triggers an injection complete indication.
  • the elongate flexible member may be disposed within the housing, for example in a rearward portion of the housing.
  • the motion of the plunger or actuation mechanism may draw the first end of the flexible member through the housing (for example forward within the housing).
  • the elongate flexible member may for example be a ribbon.
  • the flexible member may be a string.
  • the flexible member may be formed from any convenient pliable material. Typically, the flexible member will be substantially inextensible.
  • the flexible member may for example be paper or plastic.
  • the movement of the forward end of the flexible member may be arranged to unravel the flexible member from an initial position in which at least a portion of the flexible member follows a tortuous path.
  • the portion of the flexible member may be coiled.
  • the flexible member may be folded (for example in a concertina manner) in the initial position.
  • the injection complete indication may be one or more of an audible, tactile or visual indication.
  • a visual indication may be provided via a viewing window with which a portion of the flexible member may be aligned in its initial position. As the flexible member is drawn forwards the flexible member may move out of alignment with the viewing window. Alternatively, or additionally, as the flexible member is drawn forwards a second portion may be brought into alignment with the viewing window. For example the, or each, portion of the flexible member may be provided with a marking or colour to provide the visual indication.
  • An audible or tactile indication may be provided by the motion of the flexible member.
  • the flexible member may have a textured surface to provide an audible and/or tactile "click" upon movement.
  • at least a portion of the surface of the flexible member could be formed with a "saw-tooth” or ratchet type profile.
  • a tooth (or pawl) may be provided associated with the housing for engaging the textured surface of the flexible member with the interaction between the tooth and textured surface provide an audible indication as the surfaces passes the tooth.
  • the rear end of the flexible member may engage, strike or flick a surface within the injector to provide an audible or tactile indication upon its unravelling.
  • the rear end of the flexible member may be arranged to strike a percussive surface at the end of the movement to provide an audible or tactile injection complete indication.
  • a flexible member in the form of a coiled spring which may for example be formed from a thin strip of metal.
  • the percussive surface may include at least a portion of the surface having a "saw-tooth” profile (to provide a series of audible and/or tactile "clicks" as the flexible member passes over the surface).
  • the tip of the flexible member may engage the sawtooth surface during movement of the plunger. Thus, the tip may act as a tooth or pawl.
  • the flexible member may be curved or folded over a structure within the injector (for example a fixed part of the actuation mechanism or housing).
  • the structure may act as a fulcrum about which the flexible member pivots during movement.
  • the flexible member may have a selected degree of resilience the pivoting over the member may cause the end of the flexible member to splay (for example in a radially outward direction) into contact with a percussive surface.
  • the flexible member In at least its initial position the flexible member may be threaded between an opposed pair of injection indicator elements.
  • a gap or nip may be defined between the elements through which the flexible element is threaded in at least its initial position. Movement of the flexible member through the nip between the elements may trigger the injection complete indication.
  • the elements may be relatively moveable.
  • the elements may be biased towards a closed position.
  • the flexible member may be arranged to hold the injector elements out of contact (i.e. when it is positioned within the nip between the elements).
  • the length of the flexible member may be selected such that the rear end of the flexible member exits the nip between the injection indicator elements upon completion of effective dose delivery. In order to allow for tolerances the flexible member may exit the nip slightly prior to the forward most position of the plunger or actuation mechanism.
  • the injection indicator elements may be arranged to provide a mechanical indication.
  • the flexible member may click through the elements.
  • the elements may be arranged to mechanically strike thereby providing an audible or tactile injection complete indication.
  • the injection indicators elements may comprise a pair of electrical contacts.
  • the elements may form a switch which is triggered by the movement of the flexible member so as to provide an injection complete indication.
  • the flexible member may act as an isolating insulator between the contacts when it its initial position.
  • the electrical contacts may connect when the flexible member exits the nip between the elements.
  • the flexible member may comprise at least one contact.
  • The, or each, contact may initially be provided on a portion of the flexible member which is position rearwardly relative to the indicator elements (for example on the portion of the flexible member follows a tortuous path) and may pass between the elements during activation such that a circuit is completed.
  • The, or each, contact may extend along the longitudinal direction of the flexible member. Such an arrangement may, for example, enable an electrical connection to be made and remain connected for a desired period of the movement of the flexible member.
  • the flexible member may comprise at least two spaced apart contacts. The contacts may each extend parallel to the longitudinal direction of the flexible member. The contacts may be spaced apart in the transverse direction.
  • a first contact may be arranged to provide an injection commencement indication and a second contact may be arranged to provide an injection complete indication. At least a portion of the first contact may be positioned forward of the second contact.
  • the forward end of the flexible member may be connected to the plunger.
  • the plunger may be provided with an internal bore through which the forward end of the flexible member extends.
  • the forward end of the flexible member may comprise a plug which is received within the bore and which may prevent rearward movement of the end relative to the plunger.
  • the flexible member may be integrally formed onto the plunger by a number of manufacturing methods. Whilst the invention has been described above, it extends to any inventive combination set out above, or in the following description or drawings.
  • Figure 1 is a cross sectional view of the first embodiment of an autoinjector in accordance with this invention in a ready to use configuration
  • FIG. 2 is a detailed view of the rearward section of the autoinjector of Figure 1;
  • FIG. 3 is a detailed view of the rearward section of an autoinjector showing an alternative embodiment of the invention
  • Figures 4(a) to (d) are cross sectional views of the autoinjector of Figures 1 and 2 showing the activation sequence
  • Figure 5 is a plunger and flexible member for use in embodiments of the invention.
  • Figure 6 is an alternative plunger and flexible member for use in embodiments of the invention.
  • Figure 7a, 7b and 7c are a partial cross sectional representation of an alternate embodiment of the invention.
  • An injector device 1 comprises a housing 10 having a generally elongate and cylindrical form within which is housed a syringe 20.
  • the rear portion of housing 10 includes an actuation mechanism 30 which may be of any convenient form and is arranged to move a plunger 40 between a first, rearward, position as shown in Figure 1 and a second, forward, position (shown for example in figure 4) such that the plunger may express a dose from the syringe 20.
  • the actuation mechanism is of the type which initially moves the syringe forward from within the housing such that the needle of the syringe may automatically penetrate the skin and then subsequently continues to move the plunger relative to the syringe to express the entire dose of medicament from within the syringe.
  • the present invention is not limited to any particular actuation mechanism and it will, therefore, be appreciated that in other embodiments the actuation mechanism may be arranged to only partially move the plunger in response to the activation (and therefore the second position may be one in which the plunger has only moved partially along the syringe). It will also be appreciated that other injector arrangements are known in which the needle protrudes from the housing prior to firing such that it is manually inserted into the skin (and the syringe may be fixed relative to the housing).
  • the plunger 40 is provided with a bore 46 which extended from the head of the plunger 42 to the rear end of the plunger 44.
  • a flexible member 50 is provided which has a forward end 52 which is connected to the plunger 40 via a plug 56 which is seated within the bore 46.
  • the plug 56 is permanently attached to the forward end 52 of the flexible member 50 and is slidingly received within a forward portion 46a of the bore within the plunger 40.
  • a rearward section of the bore 46b has a reduced internal diameter and a shoulder 48 is defined between the first 46a and second 46b portions of the bore.
  • the flexible member 50 may be attached to the plunger 40 by any suitable means.
  • the flexible member 50 may be permanent attached to the plunger.
  • the plunger 40 and flexible member 50 may be co-moulded or plastic-welded.
  • the flexible member 50 is initially arranged to follow a tortuous path such that it is folded along its longitudinal length. This provides a compact initial arrangement of the flexible member 50 and preferably enables it to be fitted within the housing with little or no increase in size of the injector.
  • the rear portion of the flexible member 50 is arranged as a coil 58.
  • the tortuous portion may be folded in a concertina manner 58'. It will be appreciated any convenient shape may be selected for the tortuous portion depending upon the available space within the housing 10 (and taking into account the manner and direction in which the flexible member 50 will unravel during activation).
  • the flexible member is threaded through the nip 64 defined between two opposing indicator elements 60, 62.
  • the indicator elements 60, 62 are resiliently biased towards a closed position (for example by being formed on resilient plastic members) and are held apart by the presence of the flexible member 50.
  • the forward indicator element 60 has a generally planar profile and the upper indicator element 62 is provided with a rounded profile which helps to guide the flexible member 50 as it unravels from the coil 58.
  • the indicator elements 60, 62 may comprise a pair of electronic contacts which in the initial position of Figures 1 to 3 are held apart (or insulated from one another) by the presence of the flexible member 50 within the nip 64.
  • Figure 4(a) shows the injector device shortly after a user has depressed the activation trigger resulting in the release of the plunger 40 which is propelled forward by the spring of the actuation mechanism 30.
  • the plunger acts to drive the syringe 20 forwards such that the needle may penetrate the skin but (due to the compressibility of the medicament within the syringe) the plunger does not initially move the piston of the syringe relative to the syringe body.
  • the plug 56 is captive within the bore 46 and results in the forward end 52 of the flexible member 50 being drawn forward with the plunger 40.
  • the coil 58 has begun to unravel such that the flexible member 50 may extend along the axial direction of the injector device.
  • Figure 4(c) shows the rear end of the injector device in greater detail in a simila r position to that of Figure 4(b). It will be noted that in Figure 4(c) the rear end 54 of the flexible member 50 is positioned with the nip 64 between the indicator element 60 and 62. This position represents the configuration of the device with the plunger is in a forward position but has not yet completed delivery of a full dose. As shown in Figure 4(d) the plunger continues its forward motion and draws the flexible member 50 further forward such that the end 54 exits the nip 64. Due to their resilient bias the indicator elements 60 and 62 close together upon removal of the flexible member 54 resulting in the completion of an electrical circuit.
  • connection is made slightly before the plunger 40 has completed its forward movement to allow for extremes of tolerance.
  • an audible, visual and/or tactile indication is provided (for example by means of a sounder, motor, speaker, LED, or piezoelectric actuator).
  • the activation circuit is arranged to have a predetermined delay between the connection being made between the indicator element 62 and 60 and the issue of an injection complete indication of an indication to the end user to ensure that the medicament has been fully delivered dissipated and to compensate for the tolerance allowance in the length of the flexible member 50.
  • One convenient means for providing such multiple indications is to provide a plurality of electrical contacts on the flexible member 50 which are arranged to come into contact with the indicator elements 60 and 62 at a desired point during the activation of the injector device. Examples of a flexible member 50 arranged to provide such signals are shown in Figures 5 and 6.
  • the flexible member includes a first 55a and second 55b contact strips which each extend parallel to the longitudinal direction of the flexible member 50 and which are spaced apart in the transverse direction.
  • the contact strips each extend from the rearward end 54 of the flexible member 50 to a different forwardmost position. It will be appreciated that the forwardmost position of each strip 55 defines the point at which the contact strip will come into contact with the indicator elements 60 and 62.
  • the contract strips allow easy adjustment of the point during the actuation process of the injector at which the indication is activated.
  • the first contact strip 55a would be arranged to initiate a low power mode on an indicator for example, an LED within the injector device (for example an indicator mounted to or within the plunger and visible through the housing) to provide the user with an indication that administration of an injection has commenced.
  • the second contact strip 55b comes into the contact to make a secondary circuit as the actuation mechanism reaches it forwardmost position.
  • the second strip 55b may switch the LED to a second state for example to a high power mode or to a pulsing mode and may also initiate a secondary indication of completion of the injection (for example a tactile and/or audible indication).
  • FIG. 6 shows an alternative arrangement to that of Figure 5 in which the spaced apart contact 55a' and 55b' provided on the flexible member 50' are spaced apart along the longitudinal direction of the flexible member and extend only locally in the longitudinal direction.
  • an electrical indicator circuit may be provided which provides a first indication in response to the first connection being made (when contact 55a' passes through the indicator elements 60 and 62) and to display a second (and preferably distinct) indication when the second contact 55b' is aligned with the indicator elements 60 and 62.
  • FIGS. 7a to 7c Alternate embodiments of the invention are illustrated in figures 7a to 7c.
  • the elongate flexible member 150 extends to the head 142 of the plunger 140 and effectively replaces the stem of the plunger. At least the forward section of the elongate flexible member 150 is held under tension by the actuation mechanism 130 (which includes a spring).
  • the actuation mechanism 130 which includes a spring.
  • flexible elongate member will initially be held by a latch which is releasable in use by the movement of the activation trigger 115 so as to enable the spring of the actuation mechanism 130 to drive the plunger 140 forwards (and that the particular arrangement of such a latch is not an essential feature of the invention).
  • the flexible elongate member 150 is provided with a textured surface in the form of a saw tooth profiled section 155 at, or proximal to, its rear end 154.
  • a pawl 160 in the form of a resilient finger is provided as an indicator element.
  • the pawl is associated with the trigger 115 (but could be otherwise associated with the housing 110) such that the plunger 140 and elongate member 150 move relative to the pawl 160 during activation of the device.
  • the pawl 160 is positioned so as to engage the elongate flexible member 150 as the elongate flexible member moves forwardly during activation.
  • the length of the elongate flexible member 150 and the position of the saw tooth section 155 are selected such that when the plunger approaches the delivery complete position the pawl 160 will come into contact with the saw tooth profile section 155. The pawl 160 will then be deflected across each tooth to provide an audible (and optionally tactile) click.
  • Figures 7b and 7c illustrate a variation of the embodiment of figure 7a, in which the indicator element 160' is provided as a saw-toothed surface formed on a portion of an interior surface of the trigger 115' (or other part of the housing 110').
  • the tip at the end 154' of the elongate flexible member 150' acts, in effect, as a pawl which moves across the saw tooth surface 160' during actuation.
  • the elongate flexible member 150' is arranged in a configuration where it is folded over a rearward surface of a structure 112' formed on the interior of the housing (in the example by part of the latch of the actuation mechanism 130') so that it has a substantially U-shaped profile within the housing.
  • the structure 112' provides a fulcrum about which the elongate flexible member 150' folds as it is dragged forward with the plunger movement.
  • the length of the elongate flexible member 150 is such that the end 154' of the elongate flexible member 150' will come into alignment with the surface 160'.
  • the end 154' will splay outwardly towards the surface 160' due to the flexing over the fulcrum 112' and the resilience of the elongate flexible member 150'.
  • the tip of the end 154' will engage the teeth of the saw tooth surface 160' and will be deflected across each tooth to provide an audible (and optionally tactile) click.
  • the device may be a single use device and, for example, the syringe may be integrally formed with the housing.
  • the skilled person will appreciate that there may be additional sequences in the operation of an injector which it would be desirable to trigger in response to the successful delivery of a dose of medicament.
  • the mechanical or electrical detection of the movement of the flexible member provided by embodiments of the invention may be utilised to trigger other sequences in addition or as an alternative to an injection complete indication sequence.
  • the flexible member may be utilised to initiate the commencement of a retraction sequence for the syringe, or to initiate the release of a shroud to cover the exposed needle.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un dispositif d'injection comprenant un boîtier (10), un piston (40) pour expulser un médicament d'une seringue (20) et un mécanisme d'actionnement (30). Le mécanisme d'actionnement (30) est disposé en utilisation pour déplacer le piston (40) entre une première position vers l'arrière et une seconde position vers l'avant pour expulser une dose de la seringue (20). Le dispositif d'injection comprend en outre un capteur d'activation d'injection (50) disposé par exemple pour donner une indication de fin de dose. Le capteur (50) comprend un élément souple allongé. L'élément souple présente une première extrémité (52) raccordée au piston (40) ou au mécanisme d'actionnement (30) de façon à ce que le mouvement d'actionnement du dispositif d'injection serve à déplacer l'élément souple allongé (50) par rapport au boîtier. Le déplacement de l'élément allongé (50) déclenche une réaction à l'injection comme une indication audible et/ou tactile de fin de l'injection.
PCT/GB2014/052391 2013-08-05 2014-08-05 Dispositifs d'injection WO2015019071A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP14750796.6A EP3030288B1 (fr) 2013-08-05 2014-08-05 Dispositifs d'injection
CN201480044256.0A CN105451792B (zh) 2013-08-05 2014-08-05 注射装置
JP2016532732A JP2016528983A (ja) 2013-08-05 2014-08-05 注射装置
US14/910,155 US10183121B2 (en) 2013-08-05 2014-08-05 Injection devices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1313982.9A GB2516896B (en) 2013-08-05 2013-08-05 Injection devices
GB1313982.9 2013-08-05

Publications (1)

Publication Number Publication Date
WO2015019071A1 true WO2015019071A1 (fr) 2015-02-12

Family

ID=49224168

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2014/052391 WO2015019071A1 (fr) 2013-08-05 2014-08-05 Dispositifs d'injection

Country Status (6)

Country Link
US (1) US10183121B2 (fr)
EP (1) EP3030288B1 (fr)
JP (1) JP2016528983A (fr)
CN (1) CN105451792B (fr)
GB (1) GB2516896B (fr)
WO (1) WO2015019071A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101653266B1 (ko) * 2015-07-23 2016-09-01 (주)엠큐어 휴대용 약물주입기
WO2018039769A1 (fr) * 2016-08-29 2018-03-08 Duoject Medical Systems Inc. Auto-injecteur
JP2018511384A (ja) * 2015-03-12 2018-04-26 サノフイ 薬物送達デバイス
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US11400232B2 (en) 2017-11-03 2022-08-02 Sanofi Drug delivery device
US11654246B2 (en) 2017-11-03 2023-05-23 Sanofi Drug delivery device

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US20160193415A1 (en) 2016-07-07
GB2516896A (en) 2015-02-11
GB2516896B (en) 2020-08-12
GB201313982D0 (en) 2013-09-18
CN105451792A (zh) 2016-03-30
CN105451792B (zh) 2019-08-16
EP3030288B1 (fr) 2021-04-21
EP3030288A1 (fr) 2016-06-15
JP2016528983A (ja) 2016-09-23
US10183121B2 (en) 2019-01-22

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