WO2015003779A3 - Vorrichtung und verfahren zur modellierung einer hornhaut - Google Patents

Vorrichtung und verfahren zur modellierung einer hornhaut Download PDF

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Publication number
WO2015003779A3
WO2015003779A3 PCT/EP2014/001791 EP2014001791W WO2015003779A3 WO 2015003779 A3 WO2015003779 A3 WO 2015003779A3 EP 2014001791 W EP2014001791 W EP 2014001791W WO 2015003779 A3 WO2015003779 A3 WO 2015003779A3
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WO
WIPO (PCT)
Prior art keywords
cornea
finite element
tissue sections
distribution function
element model
Prior art date
Application number
PCT/EP2014/001791
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English (en)
French (fr)
Other versions
WO2015003779A2 (de
Inventor
Harald P. STUDER
Hansjörg Riedwyl
Philippe Büchler
Cynthia J. ROBERT
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Iss Integrated Scientific Services Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iss Integrated Scientific Services Ag filed Critical Iss Integrated Scientific Services Ag
Priority to EP14736629.8A priority Critical patent/EP3019990B1/de
Priority to ES14736629.8T priority patent/ES2665146T3/es
Priority to US14/903,674 priority patent/US10181007B2/en
Publication of WO2015003779A2 publication Critical patent/WO2015003779A2/de
Publication of WO2015003779A3 publication Critical patent/WO2015003779A3/de

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    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F30/00—Computer-aided design [CAD]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F9/00825—Methods or devices for eye surgery using laser for photodisruption
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F30/00—Computer-aided design [CAD]
    • G06F30/20—Design optimisation, verification or simulation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16Z—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR
    • G16Z99/00—Subject matter not provided for in other main groups of this subclass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • A61B2034/101—Computer-aided simulation of surgical operations
    • A61B2034/105—Modelling of the patient, e.g. for ligaments or bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00853—Laser thermal keratoplasty or radial keratotomy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00897—Scanning mechanisms or algorithms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/013—Instruments for compensation of ocular refraction ; Instruments for use in cornea removal, for reshaping or performing incisions in the cornea

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Geometry (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Computer Hardware Design (AREA)
  • Evolutionary Computation (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Data Mining & Analysis (AREA)
  • Pathology (AREA)
  • Robotics (AREA)
  • Vascular Medicine (AREA)
  • Databases & Information Systems (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Prostheses (AREA)
  • Instructional Devices (AREA)

Abstract

Zur Modellierung einer Hornhaut für die Simulation von Gewebeschnitten in der Hornhaut, wird ein patientenspezifisches Finite Elemente Modell der Hornhaut erzeugt (S2). Im Finite Elemente Modell wird eine erste Gruppe von Gewebefasern, mit parallel zur Oberfläche der Hornhaut verlaufenden Hauptfasern, gemäss einer ersten Verteilungsfunktion verteilt (S22). Im Finite Elemente Modell wird überdies eine zweite Gruppe von Gewebefasern, mit inklinierten, nicht parallel zur Oberfläche der Hornhaut verlaufenden Crosslink-Fasern, gemäss einer zweiten Verteilungsfunktion verteilt (S23). Dabei verteilt (S23) die zweite Verteilungsfunktion die Crosslink-Fasern mit einer nicht uniformen Gewichtungsfunktion über die Tiefe der Hornhaut, von der äusseren Oberfläche der Hornhaut zur inneren Oberfläche der Hornhaut.
PCT/EP2014/001791 2013-07-10 2014-06-30 Vorrichtung und verfahren zur modellierung einer hornhaut WO2015003779A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP14736629.8A EP3019990B1 (de) 2013-07-10 2014-06-30 Vorrichtung und verfahren zur modellierung einer hornhaut
ES14736629.8T ES2665146T3 (es) 2013-07-10 2014-06-30 Dispositivo y procedimiento para el modelado de una córnea
US14/903,674 US10181007B2 (en) 2013-07-10 2014-06-30 Device and method for modelling a cornea

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13003481.2 2013-07-10
EP20130003481 EP2824599A1 (de) 2013-07-10 2013-07-10 Vorrichtung und Verfahren zur Modellierung einer Hornhaut

Publications (2)

Publication Number Publication Date
WO2015003779A2 WO2015003779A2 (de) 2015-01-15
WO2015003779A3 true WO2015003779A3 (de) 2015-03-12

Family

ID=48793856

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2014/001791 WO2015003779A2 (de) 2013-07-10 2014-06-30 Vorrichtung und verfahren zur modellierung einer hornhaut

Country Status (4)

Country Link
US (1) US10181007B2 (de)
EP (2) EP2824599A1 (de)
ES (1) ES2665146T3 (de)
WO (1) WO2015003779A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10092393B2 (en) 2013-03-14 2018-10-09 Allotex, Inc. Corneal implant systems and methods
US10449090B2 (en) 2015-07-31 2019-10-22 Allotex, Inc. Corneal implant systems and methods
US20190080043A1 (en) 2015-11-05 2019-03-14 Optimo Medical Ag Method and device for modelling human or animal tissue
TWI617284B (zh) * 2016-11-08 2018-03-11 阿格斯醫材公司 眼角膜手術風險評估方法及其系統
CN108346472A (zh) * 2017-01-24 2018-07-31 阿格斯医材公司 眼角膜手术风险评估方法及其系统
CN107766640B (zh) * 2017-10-16 2020-06-30 北京理工大学 考虑微观组织界面的颗粒增强复合材料有限元建模方法
JP7446277B2 (ja) 2018-03-13 2024-03-08 ザ ユーエービー リサーチ ファンデーション 網膜灌流及び視神経乳頭変形の共局在化検出
KR20210156839A (ko) 2019-05-03 2021-12-27 렌사르, 인크. 클라우드 기반 시스템 백내장 치료 데이터베이스 및 알고리즘 시스템
CN113345065B (zh) * 2021-08-04 2021-11-12 康达洲际医疗器械有限公司 一种基于指向性线段的曲面图像构建方法与系统

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US5891131A (en) 1993-02-01 1999-04-06 Arizona Board Of Regents Method and apparatus for automated simulation and design of corneal refractive procedures
EP1301155A2 (de) 2000-07-20 2003-04-16 The Ohio State University Verfahren sowie instrumenten zur refraktiven augenchirurgie
US7620147B2 (en) * 2006-12-13 2009-11-17 Oraya Therapeutics, Inc. Orthovoltage radiotherapy
US7496174B2 (en) * 2006-10-16 2009-02-24 Oraya Therapeutics, Inc. Portable orthovoltage radiotherapy
US7844425B2 (en) 2008-01-18 2010-11-30 Technolas Perfect Vision Gmbh Finite element modeling of the cornea
US20090318907A1 (en) 2008-06-20 2009-12-24 Bille Josef F Generalized modeling of the cornea

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ABAHUSSIN ET AL.: "3D collagen orientation study of the human cornea using X-ray diffraction and femtosecond laser technology.", INVEST OPHTHALMOL VIS SCI., vol. 50, no. 10, 10 June 2009 (2009-06-10), pages 5159 - 5164, XP002733940, Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/pubmed/19516010> [retrieved on 20141217], DOI: doi: 10.1167/iovs.09-3669 *
HARALD P. STUDER ET AL: "Patient-specific finite-element simulation of the human cornea: A clinical validation study on cataract surgery", JOURNAL OF BIOMECHANICS, vol. 46, no. 4, 1 February 2013 (2013-02-01), pages 751 - 758, XP055089802, ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2012.11.018 *
STUDER H ET AL: "Biomechanical model of human cornea based on stromal microstructure", JOURNAL OF BIOMECHANICS, PERGAMON PRESS, NEW YORK, NY, US, vol. 43, no. 5, 22 March 2010 (2010-03-22), pages 836 - 842, XP026937973, ISSN: 0021-9290, [retrieved on 20100303], DOI: 10.1016/J.JBIOMECH.2009.11.021 *

Also Published As

Publication number Publication date
US10181007B2 (en) 2019-01-15
EP2824599A1 (de) 2015-01-14
US20160162630A1 (en) 2016-06-09
WO2015003779A2 (de) 2015-01-15
ES2665146T3 (es) 2018-04-24
EP3019990A2 (de) 2016-05-18
EP3019990B1 (de) 2018-01-10

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