WO2014204416A1 - Solution utilisée dans le traitement des hémorroïdes - Google Patents

Solution utilisée dans le traitement des hémorroïdes Download PDF

Info

Publication number
WO2014204416A1
WO2014204416A1 PCT/TR2014/000175 TR2014000175W WO2014204416A1 WO 2014204416 A1 WO2014204416 A1 WO 2014204416A1 TR 2014000175 W TR2014000175 W TR 2014000175W WO 2014204416 A1 WO2014204416 A1 WO 2014204416A1
Authority
WO
WIPO (PCT)
Prior art keywords
hemorrhoid
menthol
benzyl alcohol
composition
methylene blue
Prior art date
Application number
PCT/TR2014/000175
Other languages
English (en)
Inventor
Melike Orkide TASCILAR
Original Assignee
Almediko Saglik Urunleri Turizm Gida Sanayi Ve Ticaret Limited Sirketi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almediko Saglik Urunleri Turizm Gida Sanayi Ve Ticaret Limited Sirketi filed Critical Almediko Saglik Urunleri Turizm Gida Sanayi Ve Ticaret Limited Sirketi
Publication of WO2014204416A1 publication Critical patent/WO2014204416A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Definitions

  • This invention is related to a hemorrhoid treatment solution that dissolves blood clots in hemorrhoid piles, reduces the size of hemorrhoid piles, provides instant and permanent pain relief in the hemorrhoid area, remedies irritations and cracks, helps facilitate defecation by relaxing the anal sphincter, arrests the progression of hemorrhoid and provides hygiene at the application zone by its antimicrobial formulation.
  • This composition includes menthol, Lavandula stoechas extract, benzyl alcohol, methylene blue, propylene glycol and deionized water in a colored glass bottle with a spray head.
  • Hemorrhoids or piles also known as “mayasil” and “babasil” in Turkey, are protuberances that grow out of swelling of venous networks under the mucosa membrane located on the anal duct or on the outside of anus.
  • Hemorrhoid which is a kind of varicose, is formed of protuberances are nodules comprised of arteries, veins and connective tissue which lump in the anal channel or hang out from anus. These occur due to the anal infections and abdominal pressure (pregnancy, straining, heavy lifting etc.) as well as chronic liver disease and tumors.
  • the patients have complaints such as itching and burning in anus area.
  • the condition causes a sensation of defecation and pain increases after defecation.
  • the doctor can see the cracks on the anus during an examination.
  • the blood may clot in the vascular nodules formed due to hemorrhoid.
  • the blood clotting is the main reason of pain.
  • the other reasons of pain are anal sphincter pressure and constipation caused by this, as well as the Assuring that occurs during defecation and exposure of the irritable region to microbial factors.
  • a different type of tissue generates in this zone. This new tissue may get better sometimes, but generally a positive result is not expected.
  • the Chinese patent document No. CN101773544 in the known state of the art relates to a method and a pharmaceutical drug for treatment of anorectal diseases.
  • the medicine prepared for treatment of anorectal diseases contains raw materials such as sodium sulfite, menthol crystals and ethylene tetra acetic acid, ethanol, propylene glycol, deionized water and other similar materials.
  • Sodium sulfite contracts capillaries, thus interrupting nutrient supply to lesion tissue and help dry out lesions. Menthol crystal helps relieve the pain with its crisp and cool effect.
  • CA1266237A1 in the known state of the art relates to an herbal composition used for hemorrhoid treatment, which contains menthol, terpenes and camphor, and applicable to hemorrhoid area in liquid, cream, ointment, gel, pomade and various other forms.
  • the Turkish patent document No. 2011/06345 registered with Turkish Patent Office which in the known state of the art relates to a preparation and application process of an herbal composition which contain cyclamen and olive oil developed for treatment and prevent of hemorrhoid and rectum discomfort caused by sub- mucosal venous plexus varicose, as well as physical, chemical or microbial factors such as bacterium, fungus, virus etc.
  • all mixtures prepared for treatment of hemorrhoid with a small amount of menthol provide a temporary sense of coolness, and local anesthetic agents are used for temporary pain relief.
  • the purpose of this invention is to dissolve blood clots in hemorrhoid piles, reduce the size of hemorrhoid piles, provide instant and permanent pain relief in hemorrhoid area, remedy irritations and cracks, help facilitate defecation by relaxing anal sphincter, arrest the progression of hemorrhoid and provide hygiene on application zone by its antimicrobial formulation.
  • Another purpose of this invention is to provide practical usage by placement of mixture solution in spray form, thus rendering it applicable via spray without making it necessary to touch hemorrhoid nodule and relevant zone.
  • composition developed for achieving the purpose of this invention contains menthol, Lavandula stoechas extract, benzyl alcohol and methylene blue.
  • the solution subject to this invention contains, 25% menthol, 12% Lavandula stoechas extract, 5% benzyl alcohol, 0.05% methylene blue, 35% propylene glycol, and 22.95% deionized water by weight.
  • the preferred method for production of the subject solution involves mixing 25g menthol, 12g of Lavandula stoechas extract, 5g benzyl alcohol, 0.05g methylene blue, 35g propylene glycol and 22.95g deionized water in a lOOg container.
  • the menthol in solution composition provides comfort staring from the moment of application by masking the pain and itching via heat sensation.
  • the blood clotting is one of the main reasons of pain. Menthol dissolved blood clots by accelerating blood circulation and provides hygiene by its antibacterial properties.
  • the Lavandula stoachas extract in solution composition relieves the anal sphincter. Stress on sphincter is one of the main reasons of pain. The pain is prevented by relieving this stress. The relaxation of sphincter under constipation stress prevents further irritation of hemorrhoid zone. Prevention irritation and curative cafe helps cure the cracks.
  • the benzyl alcohol in the solution composition helps to relieve pain by its local anesthetic effect. It ensures hygiene on application zone by its antimicrobial effect. It also prevents bacterial growth.
  • the methylene blue in solution composition provides hygiene by its antimicrobial effect. It gives the blue color of product.
  • the propylene glycol in solution composition provides care and softening effect for hemorrhoid zone. It also has a solvent effect in the product mixture.
  • the deionized water in solution composition ensures homogeneous dissolution the active ingredients in solution composition.
  • the subject solution is applicable without having to touch hemorrhoid nodules and relevant zone thanks to practical mode of usage provided by spray form.
  • the subject solution is offered in colored glass bottles or colored plastic bottles with a volume between 5ml and 500ml, which helps to protect the product from direct sunlight, thus prolonging product life.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cardiology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne une solution de traitement des hémorroïdes qui dissout les caillots sanguins dans les hémorroïdes enflammées, réduit la taille des hémorroïdes enflammées, produit un soulagement instantané et permanent de la douleur dans la région des hémorroïdes, guérit les irritations et les fissures, contribue à faciliter la défécation en relaxant le sphincter anal, arrête la progression des hémorroïdes et assure l'hygiène de la zone d'application grâce à sa formulation antimicrobienne. Cette composition comprend du menthol, de l'extrait de Lavandula stoechas, de l'alcool benzylique, du bleu de méthylène, du propylène glycol et de l'eau déminéralisée dans un flacon en verre teinté avec une tête de pulvérisation.
PCT/TR2014/000175 2013-06-21 2014-05-23 Solution utilisée dans le traitement des hémorroïdes WO2014204416A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2013/07510 2013-06-21
TR201307510 2013-06-21

Publications (1)

Publication Number Publication Date
WO2014204416A1 true WO2014204416A1 (fr) 2014-12-24

Family

ID=51136756

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2014/000175 WO2014204416A1 (fr) 2013-06-21 2014-05-23 Solution utilisée dans le traitement des hémorroïdes

Country Status (1)

Country Link
WO (1) WO2014204416A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023177675A1 (fr) * 2022-03-15 2023-09-21 Milehigh Repro Solutions, Llc Procédés et systèmes pour réduire une lésion dans des tissus traités

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1266237A (fr) 1984-07-26 1990-02-27 Belmac Corporation Compositions et methode pour le traitement des hermorroides
US5720962A (en) * 1995-10-04 1998-02-24 Au Pharmaceuticals, Inc. Analgesic lotion for hemorrhoids and method of making such lotion
WO1998034628A1 (fr) * 1997-02-05 1998-08-13 Au Pharmaceuticals, Inc. Composition pour le traitement des hemorroides et d'autres inflammations anorectales
US6228387B1 (en) * 2000-01-27 2001-05-08 Murray Borod Integrated comprehensive hemorrhoid treatment compositions and regimen
FR2837105A1 (fr) * 2002-03-13 2003-09-19 Jean Bringer Composition associant la propolis a une essence aromatique
CN1773544A (zh) 2005-10-14 2006-05-17 浙江信诺科技有限公司 手机条形码的生成发送与应用方法
YU32501A (sh) * 2001-05-10 2006-05-25 Dimitrije Popović Antihemoroidna smesa
CN101773544A (zh) * 2010-03-26 2010-07-14 史长山 一种治疗肛肠疾病的药物制剂及其制备方法
TR201106345A2 (tr) 2011-06-27 2011-10-21 Sari Zafer Hemoroid tedavisi ve/veya önlenmesinde kullanım için bitkisel kompozisyon ve hazırlama yöntemi.

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1266237A (fr) 1984-07-26 1990-02-27 Belmac Corporation Compositions et methode pour le traitement des hermorroides
US5720962A (en) * 1995-10-04 1998-02-24 Au Pharmaceuticals, Inc. Analgesic lotion for hemorrhoids and method of making such lotion
WO1998034628A1 (fr) * 1997-02-05 1998-08-13 Au Pharmaceuticals, Inc. Composition pour le traitement des hemorroides et d'autres inflammations anorectales
US6228387B1 (en) * 2000-01-27 2001-05-08 Murray Borod Integrated comprehensive hemorrhoid treatment compositions and regimen
YU32501A (sh) * 2001-05-10 2006-05-25 Dimitrije Popović Antihemoroidna smesa
FR2837105A1 (fr) * 2002-03-13 2003-09-19 Jean Bringer Composition associant la propolis a une essence aromatique
CN1773544A (zh) 2005-10-14 2006-05-17 浙江信诺科技有限公司 手机条形码的生成发送与应用方法
CN101773544A (zh) * 2010-03-26 2010-07-14 史长山 一种治疗肛肠疾病的药物制剂及其制备方法
TR201106345A2 (tr) 2011-06-27 2011-10-21 Sari Zafer Hemoroid tedavisi ve/veya önlenmesinde kullanım için bitkisel kompozisyon ve hazırlama yöntemi.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 201062, Derwent World Patents Index; AN 2010-M35272, XP002728215 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023177675A1 (fr) * 2022-03-15 2023-09-21 Milehigh Repro Solutions, Llc Procédés et systèmes pour réduire une lésion dans des tissus traités

Similar Documents

Publication Publication Date Title
US20170128392A1 (en) System for treatment of hemorrhoids
US9545391B2 (en) Medicated ointment for treating hemorrhoid and method of using the same
CN102772591B (zh) 一种治疗鼻炎的中空、通气、双层中药栓剂及其制作方法
WO2020211762A1 (fr) Préparation pharmaceutique lipidique et application associée
RU2470653C2 (ru) Средство для лечения ожогов и ран
CN103735620B (zh) 一种治疗痔疮的纳米乳原位凝胶
KR101067443B1 (ko) 하이드록시클로로퀸을 함유하는 치핵 치료를 위한 국소투여용 주사제 조성물
CN102716281B (zh) 一种用于术后伤口清洗的护理液
WO2014204416A1 (fr) Solution utilisée dans le traitement des hémorroïdes
Zeng et al. [Retracted] Effect of Kangfuxin Solution Fumigation Bath on Postoperative Patients with Hemorrhoid PPH and Influence on the Postoperative Complications
US20220287862A1 (en) Topical treatment for anorectal disorders with and without seat cushion
US20070078417A1 (en) Method and system for systematically treating hemorrhoids
CN102526056A (zh) 一种伏立康唑滴耳液及其制备方法和用途
JPH0692317B2 (ja) 肛門用外用薬剤
CN107890489A (zh) 一种治疗痔疮的中药软膏及其制备方法
CN108578418A (zh) 一种治疗糖尿病难愈创面并发症的组合药物
JP7331149B2 (ja) 直腸および局所投与のためのゲル
CN107362284A (zh) 一种治疗痔疮药水
KR20180077791A (ko) 항문질환용 기능성 화장료 조성물 및 항문질환용 기능성 화장료 조성물 도포 장치
US20240024400A1 (en) Unique herbal combination for the treatment of anal fissures and wounds in pharmaceutical dosage form
CN108324721B (zh) 一种药物组合物及其制备方法和用途
CN105641684A (zh) 一种用于痔疮术后恢复的喷雾剂及其制备方法
CN118319989A (zh) 一种清热燥湿、祛风止痒的外用中药组合物
CN102552295A (zh) 一种治疗内外痔的药物及其制造方法
CN103830372A (zh) 一种治疗痔疮的中药组合物及其制备方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14736486

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 14736486

Country of ref document: EP

Kind code of ref document: A1