WO2014177703A2 - Inhalator für ein dosieraerosol - Google Patents
Inhalator für ein dosieraerosol Download PDFInfo
- Publication number
- WO2014177703A2 WO2014177703A2 PCT/EP2014/059008 EP2014059008W WO2014177703A2 WO 2014177703 A2 WO2014177703 A2 WO 2014177703A2 EP 2014059008 W EP2014059008 W EP 2014059008W WO 2014177703 A2 WO2014177703 A2 WO 2014177703A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- inhaler
- channel
- metered dose
- outlet
- dose inhaler
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/003—Particle size control by passing the aerosol trough sieves or filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/75—Aerosol containers not provided for in groups B65D83/16 - B65D83/74
- B65D83/753—Aerosol containers not provided for in groups B65D83/16 - B65D83/74 characterised by details or accessories associated with outlets
Definitions
- the invention relates to an inhaler for a
- Metered aerosol which has a housing for receiving a
- Active substance container includes.
- Inhalers for metered dose aerosols are known. These usually include a housing for receiving a
- Drug container Such a drug container contains a propellant and the active ingredient. Furthermore, the active ingredient container comprises a valve, wherein upon actuation of the valve, a defined amount of the active ingredient is dispensed.
- valve In the most common inhalers, the valve is actuated by the user pressing on the drug container inserted into the housing of the inhaler.
- the housing typically includes a nebulizer nozzle through which an aerosol is dispensed into a mouthpiece of the housing which the user can breathe.
- the object of the invention is to reduce the aforementioned disadvantages of the prior art.
- Amount of active ingredient is improved.
- the invention relates to an inhaler whose handling is improved.
- the object of the invention is already by a
- the invention relates to an inhaler for a
- Metered aerosol ie a device by means of one
- Liquid especially a suspension
- an active ingredient can be delivered with an active ingredient as an aerosol cloud.
- Active ingredient is usually a drug.
- the inhaler may also be used to dispense other substances,
- the inhaler comprises a receptacle for the outlet of a drug container.
- a receptacle for the outlet of a drug container.
- Such a receptacle is usually designed as a kind of bore, in which a tube-shaped outlet of the introduced into the housing drug container can be performed.
- the inhaler comprises a channel, which extends from the receptacle for the outlet of the drug container to a Zerstäuberauslass.
- the atomizer outlet is understood to mean that the aerosol enters the mouthpiece of the inhaler at this component.
- the atomizer outlet includes one for the aerosol
- the atomizer outlet comprises a fleece, a net or a fabric.
- the channel thus includes a bottleneck.
- This constriction is formed in particular with a diameter between 0, 1 and 1 mm, preferably between 0, 3 and 0, 7 mm.
- the constriction which is located near the permeable sheet, causes the velocity of the fluid to increase sharply in the region of the constriction. The inventor suspects that in this way it is prevented that particles in larger quantities on the
- Constriction of 0, 4 to 0, 6 mm in particular of 0, 5 mm is optimal.
- a somewhat smaller diameter is optimal, in particular from 0.2 to 0.3 mm, particularly preferably 0.25 mm.
- the bottleneck is through two
- converging and tapered channel sections are formed, which are arranged at an angle to each other.
- an angle between 100 0 and 130 °, preferably between 110 ° and 120 °, found to be suitable.
- the angle of the two corresponds
- Rotation symmetry axis of the drug container runs.
- the constriction preferably extends approximately in the same inclination as a central axis of the mouthpiece.
- the permeable sheet preferably has a mean pore diameter between 10 and 100 ⁇ ,
- the diameter of the opening of the atomizer outlet is preferably between 0.5 mm and 3 mm, more preferably between 1 and 2 mm.
- average pore diameter of 50 to 70 ⁇ , in particular of about 60 ym have proven ideal.
- the permeable sheet preferably has an open area between 10 and 60%, more preferably between 25 and 45%.
- the invention further relates to an inhaler for a metered dose inhaler, in particular as described above, which has a receptacle for the outlet of a Active substance e employersers and a channel, which of the
- Recording to a Zerstäuberauslass includes includes.
- the atomizer outlet comprises the above-mentioned permeable fabric, which closes the channel by means of which the outlet of the active substance container is connected.
- This channel has a length of less than 8 mm, preferably less than 5 mm.
- this effect is due to the fact that when operating the inhaler in the channel to a pressure build-up and to an acceleration of the forming aerosol particles. This will, especially in conjunction with a
- the channel has a volume of less than 10 mm 3 , preferably less than 5 mm 3 , and particularly preferably less than 3 mm 3 .
- the invention further relates to an inhaler for a metered dose inhaler, in particular as described above, which comprises a container housing for receiving a
- Active agent container and a Zerstäuberauslass includes, which opens into a mouthpiece.
- the mouthpiece according to the invention has an extension on an opposite side to an opening for inhaling the aerosol.
- the mouthpiece is at least 10 mm above the opening at the back.
- Fig. 1 shows a schematic perspective view of an embodiment of the housing of an inhaler 1. In this view, the active substance container is not
- the inhaler 1 comprises a mouth piece 2 with an opening 3 through which the user inhales the delivered aerosol.
- the mouthpiece 2 is in an angle deviating from 90 0 , in this embodiment at an angle of 110 0 to 120 ° to a container housing 4, which at least in
- the mouthpiece 2 also has the back, so
- an extension 6, which serves the better balance when using the inhaler.
- FIG. 2 shows a perspective cutaway view of the device shown in FIG. 1 illustrated inhaler. 1
- a sprayer outlet 8 from which the aerosol cloud is released when the inhaler is actuated, can also be seen.
- the design of the receptacle 7 as a nozzle, which is formed in this embodiment substantially circular cylindrical, has the advantage that the mouthpiece 2 remains a large volume.
- This volume which is also present on the back side of the nozzle opening, can be used, for example, to integrate further Components, in particular a counter, can be used.
- the receptacle 7 is an integral part of the housing.
- FIG. 3 is a schematic sectional view of the FIG.
- Inhalator 1 wherein in this view, the drug container 10 is shown, which is inserted into the container housing 4.
- the Wirkstoffbenzol ter 10 has a collar 11 and a tubular outlet 12.
- the tubular outlet 12 is in the channel 9th
- Amount of active ingredient is delivered.
- the function of such drug container for dispensing MDIs is known in the art.
- the outlet 12 jams in the channel 9 and thus secures the drug container 10 used from falling out. It is also conceivable, however, to provide the container housing 4 with further clamping means (not shown), which in particular can engage on the collar 11.
- the atomizer outlet in the mouthpiece is in
- FIG. 4 is a detailed view of the device shown in FIG. 3 too
- the channel is divided into a first channel section 13 and a second channel section 14, which in one
- First and second channel sections 13, 14 taper and are essentially this embodiment
- Both channel sections 13,14 taken together have a length of less than 5 mm and a maximum diameter of less than 2 mm. Between the channel sections 13,14 a constriction 15 is formed, which in this embodiment
- Fig. 4 only the plastic parts of the inhaler are shown, which are integral parts of the housing, which can be manufactured in one piece by injection molding.
- Fig. 5 shows the in Fig. 4, wherein now a permeable sheet 16, which serves as Zerstäuberauslass, is set in front of the channel section 14.
- the permeable fabric may be formed as a net, in particular as a nylon net with a pore diameter of 35-45 ⁇ .
- the network is secured by means of a ring 17.
- permeable fabrics 16 are particularly easy to use.
- the diameter of the permeable sheet 16 according to the invention becomes the same diameter
- Active substance container is a pressure build-up in the channel
- Particles could be reduced by more than 40% compared to known, on the market inhalers.
- FIG. 6 shows an infrared uptake of the aerosol cloud of a commercially available inhaler.
- FIG. 7 shows an infrared absorption of the aerosol cloud of an inhaler according to the invention.
- This has a volume of more than 150% of the volume of the in Fig. 6 illustrated aerosol cloud.
- the inhalation of the aerosol is considerably simplified.
- the standard deviation of the delivered dose could even be improved compared to known inhalers.
- a standard deviation of less than 10% could be achieved.
- Quantity of active substance which is produced by an inhaler having only a nozzle as a sprayer.
- an aerosol cloud of more than 1.5 times, preferably up to twice, volume could be generated, without a membrane compared to a standard inhaler.
- respirable particles in the aerosol cloud are increased by up to ten percentage points (from 35% to 45%).
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016511095A JP2016518201A (ja) | 2013-05-03 | 2014-05-02 | 定量エアロゾル用の吸入器 |
US14/787,435 US20160101244A1 (en) | 2013-05-03 | 2014-05-02 | Inhaler for a metered dose aerosol |
EP14720631.2A EP2991714A2 (de) | 2013-05-03 | 2014-05-02 | Inhalator für ein dosieraerosol |
CA2909583A CA2909583A1 (en) | 2013-05-03 | 2014-05-02 | Inhaler for a metered dose aerosol |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102013104549.9A DE102013104549B4 (de) | 2013-05-03 | 2013-05-03 | Inhalator für ein Dosieraerosol |
DE102013104549.9 | 2013-05-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2014177703A2 true WO2014177703A2 (de) | 2014-11-06 |
WO2014177703A3 WO2014177703A3 (de) | 2014-12-31 |
Family
ID=50628836
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2014/059008 WO2014177703A2 (de) | 2013-05-03 | 2014-05-02 | Inhalator für ein dosieraerosol |
Country Status (6)
Country | Link |
---|---|
US (1) | US20160101244A1 (de) |
EP (1) | EP2991714A2 (de) |
JP (1) | JP2016518201A (de) |
CA (1) | CA2909583A1 (de) |
DE (1) | DE102013104549B4 (de) |
WO (1) | WO2014177703A2 (de) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3797964B1 (de) * | 2019-09-26 | 2023-06-07 | Presspart Manufacturing S.A. | Spritzgiesswerkzeug für inhalator abgemessener dosen |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4706663A (en) | 1986-04-25 | 1987-11-17 | Makiej Paul A | Particle catcher for inhalation devices |
DE60132666T2 (de) | 2000-02-09 | 2008-12-11 | Glaxo Group Ltd., Greenford | Betätigungsdüse einer dosieraerosole |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US706663A (en) | 1902-02-24 | 1902-08-12 | Frank S Ingoldsby | Dump-car. |
GB2276101A (en) * | 1993-03-19 | 1994-09-21 | Csb Moulds Ltd | Spray nozzles for pharmaceutical inhalers |
US6293279B1 (en) * | 1997-09-26 | 2001-09-25 | Trudell Medical International | Aerosol medication delivery apparatus and system |
DE60027714T3 (de) * | 1999-05-20 | 2008-01-24 | Kos Life Sciences, Inc., Weston | Zerstäubungssystem mit niedriger spraykraft und retention |
CA2536876A1 (en) * | 2003-08-29 | 2005-03-17 | Glaxo Group Limited | Pharmaceutical metered dose inhaler and methods relating thereto |
WO2006095163A1 (en) * | 2005-03-08 | 2006-09-14 | Incro Limited | Nozzle comprising a flow control apparatus |
BRPI0715887A2 (pt) * | 2006-08-22 | 2013-09-17 | Glaxo Group Ltd | atuador para um inalador para liberar medicamento por inalaÇço, inalador, e, kit de partes |
EP2011534A1 (de) * | 2007-07-03 | 2009-01-07 | CHIESI FARMACEUTICI S.p.A. | Aktuator für einen Inhalator für abgemessene Dosen |
CN102803555A (zh) * | 2009-05-06 | 2012-11-28 | 3M创新有限公司 | 药物吸入装置 |
-
2013
- 2013-05-03 DE DE102013104549.9A patent/DE102013104549B4/de not_active Expired - Fee Related
-
2014
- 2014-05-02 CA CA2909583A patent/CA2909583A1/en not_active Abandoned
- 2014-05-02 EP EP14720631.2A patent/EP2991714A2/de not_active Withdrawn
- 2014-05-02 US US14/787,435 patent/US20160101244A1/en not_active Abandoned
- 2014-05-02 JP JP2016511095A patent/JP2016518201A/ja active Pending
- 2014-05-02 WO PCT/EP2014/059008 patent/WO2014177703A2/de active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4706663A (en) | 1986-04-25 | 1987-11-17 | Makiej Paul A | Particle catcher for inhalation devices |
DE60132666T2 (de) | 2000-02-09 | 2008-12-11 | Glaxo Group Ltd., Greenford | Betätigungsdüse einer dosieraerosole |
Also Published As
Publication number | Publication date |
---|---|
DE102013104549A1 (de) | 2014-11-06 |
WO2014177703A3 (de) | 2014-12-31 |
EP2991714A2 (de) | 2016-03-09 |
DE102013104549B4 (de) | 2015-08-13 |
US20160101244A1 (en) | 2016-04-14 |
CA2909583A1 (en) | 2014-11-06 |
JP2016518201A (ja) | 2016-06-23 |
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