WO2014171853A1

WO2014171853A1 - Use of water and aqueous media with a negative oxidation-reduction potential below zero as a base or solvent for pharmaceutical drugs, homeopathic preparations and dietary supplements

Info

Publication number: WO2014171853A1
Application number: PCT/RU2013/000745
Authority: WO
Inventors: Владимир Анатольевич БАРАНОВ; Алексей Станиславович МЕРКУЛОВ
Original assignee: Baranov Vladimir Anatolievich; Merkulov Aleksey Stanislavovich
Priority date: 2013-04-16
Filing date: 2013-08-28
Publication date: 2014-10-23
Also published as: RU2013117289A

Abstract

The invention relates to the field of medicine. The invention provides the use of water with an oxidation-reduction potential below zero mV as a base or solvent for pharmaceutical drugs, homeopathic preparations and dietary supplements.

Description

The use of water and aqueous media with a negative redox potential of less than zero as a base or solvent for medical, homeopathic

drugs and dietary supplements

Technical field

The invention relates to medicine, in particular, it considers the features of building the foundations or solvents for medical, homeopathic preparations and dietary supplements. In the framework of this invention we are talking about updates and solvents that use water as the main and only component or as one of the components of the aqueous medium.

State of the art

The basis of the life of the body is the balance of oxidative and reducing biochemical processes in it. Water is responsible for these processes as the main solvent — in the chemical sense — and as the main structural element of the body — in the biological sense. The intensity of redox reactions depends on the activity of electrons in aqueous solutions, which is characterized by redox potential (ORP). The higher this parameter, the more “acidic” the medium, the more it is capable of breaking down intermolecular bonds and oxidizing molecules; and vice versa: the lower the AFP, the higher its regenerative ability.

The issue of the conformity of ORP of water to the human body is taken into account in some cases in the production of medicines and cosmetics.

For example, from RU 2274465, A61K36 / 07, A61K36 / 25, publ. 04/20/2006, known compositions that contain active components from one or more types of Basidiomycotina belonging to the tubular Basidiomycotina, and active components from the root of the plant belonging to Araliaceae. Such compositions have hypoglycemic and antitumor activity. For the specified compositions is used an aqueous solution with a redox potential of less than about 1230 mV, more preferably less than about 900 mV, and most preferably less than about 330 mV.

It has been established that after the composition is obtained or after its dissolution or suspension, its redox potential, as a rule, changes with time. Therefore, the ORP of the liquid mixture should be checked from time to time to clarify that the ORP of the solution is approximately +900 mV or less. It has also been established that the redox potential of the resulting composition is of great importance, because, especially in the case of a composition with a redox potential of +900 mV or less, there is a negative correlation between the redox potential of the composition and its antitumor activity. In other words, the lower the redox potential, the stronger the antitumor activity of the composition. Thus, it is possible to increase the effectiveness of treatment.

These compositions contain only components extracted from Basidiomycotina and components extracted from the root of the plant Araliaceae. However, it has been found that other active or inactive ingredients may also be included in these compositions until the additional ingredients suppress the synergistic effect of the two above-mentioned extracted components. For example, these extracted components can be mixed with pharmaceutically acceptable carriers and additives. The effect of improving the treatment is also manifested in other forms, for example, in the form of a solution, syrup, suspension, emulsion, granules, tablets, pills, capsules, creams, lozenges, chewable tablets, suppository, eye drops, injections, aerosol, elixir, etc. .. Compositions in solid (powder) form, must be restored by adding water. It is also revealed from RU 2336880, A61KZZ / 00, A61P1 / 00, A61P11 / 06, A61P17 / 00, A61P43 / 00, publ. 10.27.2008, that when using potable water for lymphatic drainage stimulation, it has undergone baromembrane treatment and has a redox potential of +200 to +343 mV, the total salinity is from 25 to 130 mg / l and the pH is from 6.9 to 8.3 significantly increases the stimulation of lymphatic drainage in the treatment of patients with chronic skin diseases, non-cancer diseases of the gastrointestinal tract and chronic obstructive bronchitis. The first intake is carried out on an empty stomach. This tool allows you to highly systematically stimulate lymphatic drainage of body tissues by enhancing the processes of formation and transport of lymph without any undesirable irritating effects.

Water is obtained with such ORP for a means of stimulating lymphatic drainage, due to the fact that the water is preliminarily adjusted to the state of drinking water and then treated on a baromembrane unit, while water is passed through membranes, which are a semi-permeable material with a hole diameter of 0.0001- 0.005 μm, purified water has the following indicators: redox potential from +200 to +343 mV, total salinity from 25 to 130 mg / l, pH from 6.9 to 8.3. In addition, purified water can be subjected to additional processing, saturating it with macro- and microelements (calcium, magnesium, sodium, sulfur, vanadium, carbon, oxygen; iron, iodine, copper, cobalt, zinc, fluorine, selenium, silicon, silver, etc. .).

So, the ORP of the internal environment of a healthy person is always less than zero and ranges from -100 to -250 millivolts. ORP of almost any, including industrially treated drinking water, is always greater than zero and ranges from +100 to +400 millivolts. These differences in the ORP of the internal environment of the human body and drinking water mean that the activity of electrons in the internal environment of the human body is much higher, than the activity of electrons in drinking water. When ordinary drinking water penetrates the tissues of a human (or other) organism, it takes away electrons from cells and tissues, which are 80–90% water. As a result of this, the biological structures of the body undergo oxidative destruction. In order for the body to optimally use drinking water in metabolic processes, it must be conditioned according to the ORP indices, which is achieved, for example, on the basis of electrochemical activation (ECA) technologies. If the drinking water entering the body has an ORP close to the value of the ORP of the internal environment of the human body, then the water is immediately absorbed, since it has biological compatibility in this parameter. If drinking water has an ORP more negative than the ORP of the internal environment of the body, then it feeds it with this energy, which is used by the cells as an energy reserve of the antioxidant defense of the body from the adverse effects of the external environment.

Scientists from the Institute of Organoelement Compounds named after A.N. Nesmeyanov of the Russian Academy of Sciences, and from Moscow State University named after M.V. Lomonosov in collaboration with Fiuggi water experts Eugenia Girbul, measured the pH and ORP of Fiuggi mineral water at the source and found that ORP ( Redox potential) and the pH of the mineral water in Bonifacia Park in one of the closest places to the exit of water from the earth at a temperature of 19 ° C; the ORP averaged -32.5 mV at pH 7.44. In other fountains located 100-150 m from this place, the ORP is -27.3 mV at pH 7.38. This means that Fiuggi mineral water has reducing properties. For comparison, the redox potential of tap water in the park turned out to be equal to an average of +26.0, and pH 6.5. Those. tap water has oxidizing properties. This situation, unfortunately, is typical of tap water, and is associated with the peculiarities of its treatment. Redox potential of intercellular fluid human is in the range from -100 to -200 mV at a blood pH of about 7.4. Those. the internal environment of a person, like Fiuggi's mineral water, is in a restored state. And the closer the parameters of the consumed water to the parameters of the body, the more useful the water. A negative redox potential, along with low mineralization and the presence of humic acids in the water, is another reason for the healing effect of Fiuggi mineral water.

Typically, the ORP of the human body ranges from -90 mV to -200 mV, and the ORP of ordinary drinking water is almost always significantly above zero: tap water from +80 mV to +300 mV, water in plastic bottles from +100 mV to +300 mV, and well, spring water from +120 mV to +300 mV. Negative ORP of natural water is an extremely rare phenomenon. When drinking ordinary water, the activity of electrons in the internal environment of the body is higher than the activity of electrons in it. Those. such drinking water takes free electrons from the biological environment of the body, i.e. is an oxidant. This leads to premature aging, chronic diseases, chronic fatigue. Conversely, a negative ORP of drinking water gives energy to cells, organs, and systems. The electrical energy of cell membranes is not spent on the correction of the activity of electrons of water and water is immediately absorbed, because possesses biocompatibility in this parameter. Negative ORP drinking water is an ideal antioxidant.

The second evidence of the benefits of low OPV water for the human body is information about the properties of melt water. Despite the fact that melt water has been known for several centuries, interest in it is due to its benefits for health and beauty, the ability to rejuvenate the body and prolong life. In fact, melt water is almost perfectly pure and is no different from distilled water. The composition of melt water does not include any macro- and microelements, including those useful for the body. The only exception is a change in its redox formula. b potential. Melt water in its composition and structure resembles human blood (in some sources they write that it resembles blood plasma), which is why it is very useful. In fact, only saline can be compared with blood plasma. It is this artificially prepared solution that approaches the plasma composition in terms of salt composition and osmotic pressure. The most popular advice regarding the use of melt water is washing with pieces of ice, which "refreshes and rejuvenates the skin of the face." It really is. However, the anti-aging effect is explained not so much by the composition of melt water, but by its temperature, mostly very low. Short-term exposure to cold improves blood circulation and gives the skin a healthy look. Beauticians recommend periodically wiping the skin on the face with ice cubes.

Disclosure of invention

The present invention is aimed at achieving a technical result, which consists in increasing the effectiveness of exposure to the human body of water-containing medicamentous, homeopathic preparations and dietary supplements by eliminating the use of free electrons from the biological environment of the body with water.

The specified technical result is achieved by the use of water and aqueous media with a negative redox potential of less than zero mV as a base or solvent for medicamentous, homeopathic preparations and dietary supplements.

These signs are essential for achieving a technical result.

Description of the figures of the drawings

In FIG. 1 - shows a graph of the change in the ORP in an open container: a decrease in the ORP when purging with hydrogen through the upper layer of water water volume 1 l. The hydrogen purge rate of 1 l / h. After 24 hours, the ORP becomes minus 450 mV.

FIG. 2 - shows a graph of changes in redox potential in an open container: an increase in redox potential saturated with hydrogen when stored in an open container with a liquid volume of 250 ml.

The best embodiment of the invention

The authors conducted studies on the use of water with a low (negative) AFP to increase the effectiveness of drugs, homeopathic medicines and dietary supplements (biologically active additives), which use water or an aqueous solution as a base, which is used as a base or dilution of drugs or homeopathic or dietary supplements compositions comprising at least one active substance.

It was found that homeopathic information recorded on any liquid medium (including gel forms) with negative AFP (less than 0 mV) allows using not only an order of magnitude to improve the digestibility of the drug by the human body, but also energize it.

The main processes that ensure vital activity are redox reactions. The energy released during these reactions is spent on the regeneration of body cells and maintaining homeostasis - the relative dynamic constancy of the composition and properties of the internal environment. In the course of redox reactions, the electric potential of substances changes: one substance gives off its electrons and oxidizes, acquiring a positive charge, the other accepts electrons and, being charged negatively, is restored. The difference in electrical potentials between them is the redox potential (ORP).

ORP, which is also called the redox potential, characterizes the degree of electron activity in redox reactions. The greatest oxidizing ability is oxygen, and the reducing ability is hydrogen.

Differences in the ORP of the internal environment of the human body and drinking water mean that the activity of electrons in the internal environment of the human body is much higher than the activity of electrons in drinking water. If the fluid entering the body has an ORP close to the value of the ORP of the internal environment of the human body, then the electrical energy of the cell membranes (the vital energy of the body) is not spent on correcting the activity of the electrons of this fluid, and it is immediately absorbed, since it has biological compatibility in this parameter. If the incoming liquid has an ORP more negative than the ORP of the internal environment of the body, then it feeds it with this energy, which is used by the cells as an energy reserve of the antioxidant defense of the body from the adverse effects of the external environment.

To confirm the hypothesis about the possibility of enhancing the activation of drugs, homeopathic medicines and biologically active additives by using water with low (below zero mV) AFP as a direct filler or the basis or component of an aqueous solvent, studies were conducted on the stability of low AFP water for at least a specified period of time (for example, up to three days).

The measurement results of the characteristics of the water prepared by the methods of RU 71331 and 71332 showed the following.

In non-hydrogenated water, the content of dissolved oxygen decreases in 40 days from 13 to 7.9 mg / l, the potential decreases from 570 to 120 - 150 mV. In the water charged immediately, the oxygen content decreases strongly, after 40 days there is almost no oxygen left, the ORP drops to -350 mV. In the stagnant water, the concentration of dissolved oxygen also decreases, but with a long exposure time (1 1 - 40 days), oxygen in the solution remains noticeably more. ORP immediately hydrogen-charged water decreases more slowly than in stagnant water, although it reaches approximately the same values. In the settled distilled water, characterized in that it has a lower concentration of dissolved oxygen, and during its processing there are no stages when active particles can form, after 1 hour (0.041 days) the ORP has decreased to - 170 mV, although the concentration of dissolved oxygen has not yet has changed. It clearly shows a tendency to more quickly decrease ORP and achieve lower potential values. It is noteworthy that in the water treated with cold plasma after long standing (40 days), the concentration of dissolved oxygen in the water is almost the same as in distilled, although the potential is much lower. Over 5 hours (0.21 days) in the first three types of water, the potential decrease was 250 - 350 mV, while in distilled water the potential decreased by -700 mV.

When water is saturated with hydrogen and oxygen and equilibrium is established, the solution potential will be determined by the sum of equilibrium potentials φ ₁ ° (ρΗ = 7) + φ ₂ °, which is close to zero. With decreasing oxygen concentration, the ORP of the solution will decrease. The oxygen content decreases when it is spent on the oxidation of hydrogen.

Thus, we can say that the slow establishment of the potential in the presence of dissolved oxygen and hydrogen in water is due to the consumption of oxygen in the reaction with hydrogen. If the amount of dissolved hydrogen is greater than is necessary for the reaction with oxygen, then after spending all the oxygen in the water, hydrogen remains, which determines the value of the redox potential. It should be emphasized that if water is saturated with hydrogen and oxygen to the limit of solubility, there will always be enough hydrogen to completely consume oxygen, and a negative ORP will be obtained.

In the case of electrolysis, dissolved oxygen instantly reacts at the cathode with atomic hydrogen, and the oxygen concentration in the catholyte is zero. The formation of OH ions ^"in the catholyte increases the pH value, so when the electrolysis of the ORP of catholyte will always be less than just when saturated with hydrogen, and this difference can be of the order of 400 mV if neutral water was subjected to electrolysis.

The observation of reduction reactions in aqueous solutions saturated with hydrogen, in particular, the reduction of molecular iodine, manganese, and iron compounds, shows that the measured value of the potential is due not only to the electrode processes on platinum, but to the real properties of the solution. To restore the compounds in solution, hydrogen is consumed. The recovery process stops after the complete consumption of hydrogen, if it is not enough to recover all substances, and the ORP of the solution does not change. When the concentration of hydrogen with a guarantee exceeds the stoichiometrically necessary amount for reduction, the hydrogen remains, and the solution potential decreases.

I did not find a direct explanation for the effect of a slow increase in redox potential when opening the surface of water saturated with hydrogen. Light gas, hydrogen must instantly diffuse from the water, since there is very little hydrogen in the atmosphere above its surface. However, if we imagine water as a network bonded by hydrogen bonds, then the introduced hydrogen can be fixed by hydrogen bonds, forming molecules of a more complex composition than H ₂ O.

The dependence of the ORP on the volume of the gas bubble remaining above the water surface after the introduction of hydrogen can be explained by a decrease in the partial pressure of hydrogen spent on the reaction with oxygen. As was shown, the process of oxygen consumption is slow, it can take several days or more. Therefore, the partial pressure of the initially introduced hydrogen gradually decreases, and the larger the volume of the initial bubble, the weaker the decrease in the amount of hydrogen in the bubble, and the pressure drops less. The concentration of oxygen dissolved in water in experiments on finding the dependence of the ORP on the volume of the gas bubble was the same in all samples, and the absolute amount oxygen in the sample decreased with increasing hydrogen bubble, because the volume of water decreased.

The kinetics of establishing ORP in an open 1-liter vessel with hydrogen bubbling through a surface layer 3 - ^ - 4 mm thick is shown in FIG. 1. The hydrogen feed rate was 1 l / h. It can be seen from the figure that one hour after the start of the purge, the ORP reaches a value of minus 150 mV, after 2.5 3 hours, approximately minus 300 mV. After a day, the purge is established ORP = - 450 mV.

The kinetics of increasing ORP during storage of hydrogen-saturated water in an open vessel with a volume of 250 ml is shown in FIG. 2. The initial value of the ORP minus 520 mV. Over 6 hours, the ORP increases to minus 380 mV. Then within three days, the ORP increases to minus 100 mV.

Thus, based on the experiments, the following conclusions were obtained:

1. The potential establishment time in a bottle filled with hydrogen is approximately 1 day.

2. The value of the established potential depends on the amount of hydrogen introduced: the potential increases with increasing volume of hydrogen in the bottle and tends to reach a plateau.

3. The pH value of distilled water, simply purified water and all investigated aqueous solutions does not change when saturated with hydrogen.

4. The value of the potential established after 24 hours depends little on the type of dissolved substance and its concentration if the dissolved substance does not interact with hydrogen.

5. The increase in ORP during storage of the initially hydrogenated solution is associated with the leakage of hydrogen from the bulk. If there is no hydrogen leak, no increase in potential is observed.

6. The main role in lowering the ORP in the studied processes is played by hydrogen dissolved in water. The contribution of other processes, which can also lead to a decrease in redox potential, is much less. After obtaining data on the ORP stability of water, preparations were prepared based on water with an ORP below zero (-200 mV).

Studies have been conducted on the use of water with AFP with -200 mV for disinfection and sterilization of instruments, rooms, equipment, care items, skin and mucous membranes, etc., as well as for the treatment of purulent wounds. Tests have shown that they, when exposed for 5-10 minutes for rinsing the oral cavity, reduce the seeding by microorganisms of the oral cavity and pharynx by 25-100 times, which is confirmed by their successful use for rinsing with diseases of the throat. The use of wetted wipes allows you to completely clean the wound cavities with gunshot wounds, phlegmon, abscesses, trophic ulcers, mastitis, extensive purulent-necrotic lesions of the subcutaneous tissue in 3-5 days, and subsequent use within 5-7 days significantly accelerates the reparative processes. There is also evidence of the high therapeutic efficacy of electroactivated solutions for non-specific and candidal colpitis, endocervicitis, residual urethritis, cervical erosion, corneal ulcers, purulent keratitis, infected wounds of the eyelids, for the correction of dysbiosis and immune disorders, in the treatment of stomatitis, gingivitis, parade with diseases of the stomach; in the treatment of salmonellosis, dysentery, as well as in the treatment of diabetes mellitus, tosillitis, purulent otitis media, oily and dry face seborrhea, hair loss, contact allergic dermatitis, wrinkle correction. A good effect was found when using water with an AFP of 200 mV for gastritis, peptic ulcer, hemorrhoids, dermatomycosis, eczema, prostate adenoma and chronic prostatitis, tonsillitis, bronchitis, chronic pyelonephritis, chronic hepatitis, viral hepatitis, deforming arthrosis, etc. .

A clear activity was revealed when using homeopathic remedies. Experiments were conducted. The homeopathic principle has been reproduced on a biological model. A reaction of one of the types of human immune cells was observed with the addition of specifically interacting with it antibodies. With a decrease in the concentration of antibodies in solution, the effect manifested itself in some dilutions, disappearing in others. Such a change in the biological activity of cells also occurred at concentration, when the probability of detecting at least one molecule in water was infinitely small.

Experiments have been conducted to study changes in the spectra of homeopathic solutions from 1 to 15 potencies (dilutions). The studies were conducted with the DNES method on natrium muraticum (NaCl). At 1 CH, the solution contains 0.01% of the substance; at 2 CH, it contains 0.0001%, etc. A relationship was observed between the average energy of hydrogen bonds in a homeopathic solution and its potentials (dilutions). In the process of dilution, the solution passes the Avogadro number. After this value, it is assumed that the solution no longer contains solute molecules. An analysis of the results shows that up to 6 CH, changes in homeopathic solutions are close to the results at 1 CH. At 5 CH, the concentration of NaCl in the solution is 10 ^"10 — the same as in the Ray experiment. From 7 to 10 CH, the results are unstable and close to the statistical error. After 11 CH, the result is close to or within the statistical error.

During initial dilutions in solutions with a large number of NaCl molecules, conditions are created for the stability of clusters formed from the starting material and water molecules. In subsequent dilutions, information is transmitted, which becomes unstable, when subsequently water molecules themselves become its transmitters, with the practical absence of the starting substance. When treating with homeopathic solutions based on water, the effect on the body is relaxing. Homeopathic solutions based on water and ethanol have a stimulating effect. Based on observations, the effect on the human body between a homeopathic solution with water at the molecular and cellular level is proved. This is obtained on the basis of bioresonance. This is the principle of homeopathy: like is treated like. Each homeopathic solution has a structuring of clusters depending on the starting substance at the quantum-mechanical level with a hydrogen bond moving in energy. In the spectrum of a homeopathic solution on NaCl in water, maximums are observed: At -0.11 eV, a minimum is observed in the energy distribution of the hydrogen bond in the homeopathic solution. In a solution of NaCl in water and ethanol, the distribution is peak opposite to that of a solution of NaCl in water. From the first solution, medical results can be obtained with neurosis, bronchial asthma and thyrotoxicosis. From the second solution, results are obtained to improve the conductivity of the nerve tissue.

However, pharmacological studies of these aqueous solutions as drugs are very few. Previously, studies were conducted at the Department of Pharmacology of the Voronezh Medical Academy. A number of other therapeutic effects of electroactivated aqueous solutions have been established, toxicity has been studied, and studies are continuing on their effects on the cardiovascular system, blood system and hematopoiesis, on the central nervous system, on the motor sphere, urogenital and urinary-metabolic system, digestive system, respiration, and also treatment in surgery.

The authors conducted a study of the antiviral activity of a stabilized aqueous solution with reducing properties in experimental infections caused by hepatitis C virus in cell cultures, showed that:

- SVRVS (stabilized aqueous solution with reducing properties, ORP = -300 mV) does not have cytotoxic properties for Vero-EB, SPEV, and PTP cell cultures for 4 or more days of cultivation.

- SIRS has virucidal activity against hepatitis C virus (HS) upon exposure to HCV-containing fluid and Eagle’s medium prepared for 1 hour and 24 hours on SIDS, the HCV titers for cell cultures are reduced by 2.3 - 3.0 lg TCD50 . - CBPBC has antiviral properties and is able to reduce the production of HCV-infected adolescents by an average of 3.0 - 4.0 lg when added immediately after adsorption of HCV on cells or 24 hours before infection of the cells with hepatitis C virus

These results unambiguously show the possibility of using water from aqueous media with an AFP below zero mV as a base or solvent for medicamentous, homeopathic preparations, and biologically active additives.

Below are the compositions with ORP below -YOmV. Observations of the compositions of the examples were conducted for more than 6 months. (at room temperature), while the value of the ORP practically does not change. A study was conducted using artificial aging of the product, which showed that the AFP does not change for 18 months. estimated time.

Example 1

Ingredients Content (g) / 100g

Apple Pectin 3-4

Peptide complex (glutathione, glutamine, 1.6-1.8

lysine)

Isoflavna soybeans 3-3.2

Broccoli, dry extract 0.1-0.2

Grape Extract 0, 1-0.2

Blackcurrant extract 0, 1-0,2

Cranberry Extract 0-1-0.2

Thiamine hydrochloride (Vitamin B 1) 0.04

Pyridoxine Hydrochloride (Vitamin B6) 0.05

Cyanocobalamin (Vitamin B 12) 75 mcg

Niacin (Vitamin PP) 0.4

Potassium Sorbate 0.06

Purified water Up to 100

Example 2

Ingredients Content (g) / 100g

Apple Pectin 3-4

Peptide complex (glutathione, alanine, 1.6-1.8

aspargin, arginine, lysine)

Red Wine Extract (Red Wine, PE) 2-3

Hawthorn Fruit Extract (Crategus 0.1-0.2

oxyacantha and monogyna)

Cranberry Extract (Cranberry PE) 0.1-0.2

Thiamine hydrochloride (Vitamin B 1) 30mg / 100g Pyridoxine Hydrochloride (Vitamin B6) 40mg / 100g

Cyanocobalamin (Vitamin B 12) 60mg / South

Niacin (Vitamin PP) 0.4

Potassium Sorbate 0.06

Purified water Up to 100

Claims

Claim

The use of water and aqueous media with a negative redox potential of less than zero mV as a base or solvent for medical, homeopathic preparations and dietary supplements.