WO2014115485A1

WO2014115485A1 - Packaging bag

Info

Publication number: WO2014115485A1
Application number: PCT/JP2013/085241
Authority: WO
Inventors: 渕田　泰司; 広泰飯塚; 恭平高橋
Original assignee: 共同印刷株式会社
Priority date: 2013-01-24
Filing date: 2013-12-27
Publication date: 2014-07-31
Also published as: TW201437102A; JPWO2014115485A1; JP6340154B2

Abstract

A packaging bag which is composed of: a non-adsorptive film (2) that is thermally bondable and is formed of 82-90% by weight of an ethylene-vinyl alcohol copolymer and 10-18% by weight of a maleic acid anhydride-modified polyolefin polymer; and a functional film (3) that comprises a heat bonding layer (31) that is formed of a polyolefin and a maleic acid anhydride-modified polyolefin polymer. The non-adsorptive film (2) and the heat bonding layer (31) of the functional film (3) are heat sealed to each other to form a bag.

Description

Packaging bag

The present invention relates to a packaging bag in which the sides of two films having different functions are bonded together by heat sealing.

A medicinal component adhesive material that percutaneously absorbs a medicinal component from the skin by affixing a patch containing the medicinal component to a living body is known. The medicinal component patch is made by laminating a pressure-sensitive adhesive layer containing a medicinal component such as a transdermal absorbent on one side of a support made of a plastic film such as polyester or polyethylene or a nonwoven fabric, and the pressure-sensitive adhesive layer is made of plastic. It is covered with a coating material. It is known that a medicinal component patch is stored in a packaging bag formed of a non-adsorbing film that does not adsorb medicinal components in order to prevent volatilization of medicinal components (Patent Document 1).

By the way, the packaging bag using a non-adsorptive film is formed in a bag shape by arranging the thermal adhesive layers of the non-adsorptive film facing each other and heat-sealing three sides or four sides of the thermal adhesive layers. . However, oxygen or moisture present inside the packaging bag adversely affects the quality deterioration of the packaged body containing a scented component or a transdermal absorbent. Therefore, in storage, a hygroscopic agent or an oxygen adsorbent is enclosed in a packaging bag together with a transdermal absorbent. However, there is a problem that the packaging bag becomes bulky by enclosing the hygroscopic agent and the oxygen adsorbent.

Also known are hygroscopic films, oxygen-adsorbing functional films, and packaging bags using them (Patent Document 2 and Patent Document 3).

JP 2012-166849 A JP-A-8-26348 JP-A-2005-280188

By using a functional film and a non-adsorptive film, it is possible to form a packaging bag having a hygroscopic function or an oxygen adsorption function. However, adhesion between the functional film and the non-adsorptive film is performed using an adhesive, not heat sealing. This is because the resin component of the heat-adhesive layer of the non-adsorptive film is different from the resin component of the heat-adhesive layer of the functional film, so that the adhesiveness is not good in heat sealing.
However, since adhesives easily adsorb scent components and medicinal components, packaging bags using adhesives are not suitable for storing packages to be packaged containing scent components, medicinal component patch materials, and the like.

In view of the above-described problems, an object of the present invention is to provide a packaging bag in which three or four sides of a non-adsorbing film and a functional film are heat sealed.

The present inventors have conducted research on the adhesiveness of the resin component of the heat-adhesive layer of the non-adsorptive film and the heat-adhesive layer of the functional film. The non-adsorptive film made of coalescence has thermal adhesiveness, and the film is easy to adhere to the heat-adhesive layer made of polyolefin and maleic anhydride-modified polyolefin polymer by heat sealing, and has strong adhesion. As a result, the present invention has been completed.

The packaging bag of the present invention is a non-adsorbing film having thermal adhesiveness comprising 82% by weight to 90% by weight of an ethylene-vinyl alcohol copolymer and 10% by weight to 18% by weight of a maleic anhydride-modified polyolefin polymer. And a functional film including a thermal adhesive layer made of 80 wt% to 20 wt% polyolefin and 20 wt% to 80 wt% maleic anhydride-modified polyolefin polymer, a non-adsorbing film and a functional film The heat adhesive layer is heat sealed and formed into a bag shape.

The non-adsorbing film has a structure in which a maleic anhydride-modified polyolefin polymer is dispersed in islands, and the aspect ratio of the acid-modified polyolefin polymer dispersed and distributed in islands is 2.0 to 9. A range of 5 is preferable.
The non-adsorbing film is preferably formed from a mixed resin obtained by polymer-alloying an ethylene-vinyl alcohol copolymer and a maleic anhydride-modified polyolefin polymer.
The thermal adhesive layer may be a film formed from a mixed resin including a polyolefin resin and a maleic anhydride-modified polyolefin resin. The maleic anhydride-modified polyolefin resin is preferably 80% by weight or less based on the polyolefin resin.

In the packaging bag of the present invention, since the non-adsorptive film and the functional film are heat-sealed, it is difficult for the scent component and the medicinal component contained in the non-package to be adsorbed to the packaging bag, and the functional film is In the case of a film having a hygroscopic function or an oxygen adsorbing function, it is not necessary to enclose a hygroscopic agent or an oxygen adsorbent in the packaging bag, and the packaging bag can be configured simply.

2 is a schematic cross-sectional view of the packaging bag of Embodiment 1. FIG. 6 is a schematic cross-sectional view of a packaging bag according to Embodiment 2. FIG. It is sectional drawing of the packaging bag of this invention which accommodated the medicinal ingredient patch. It is a graph which shows the hygroscopicity test result of a functional film.

Hereinafter, the present invention will be described in detail with respect to several embodiments.
[Embodiment 1]
As shown in FIG. 1, the packaging bag 1 of the present embodiment comprises 82 wt% to 90 wt% ethylene-vinyl alcohol copolymer (hereinafter referred to as EVOH) and 10 wt% to 18 wt% maleic anhydride. A non-adsorptive film 2 having a thermal adhesive property comprising a modified polyolefin polymer and a functional film 3 comprising a thermal adhesive layer 31 comprising a polyolefin and a maleic anhydride modified polyolefin polymer. The four sides of the heat bonding layer 31 of the adsorptive film 2 and the functional film 3 are bonded by heat sealing.

In addition, the layer 32 which comprises the functional film 3 in a figure is a layer formed from the resin component which absorbs gas components, such as a carbon dioxide, ethylene, a malodorous substance, and a volatile organic compound, and a water | moisture content. The layer that adsorbs the gas component and moisture can be obtained by kneading a material such as a filler or powder that adsorbs the gas component or moisture into a resin to form a film. As such a layer 32, for example, a film such as Moist Catch (registered trademark, Kyodo Printing Co., Ltd.) or Oxy Catch (registered trademark, Kyodo Printing Co., Ltd.) can be used.

EVOH is a saponified ethylene-vinyl ester copolymer, and the content of ethylene units is not particularly limited, but is selected in the range of 10 mol% to 70 mol%, preferably 15 mol% to 60 mol%, Furthermore, 20 mol% to 60 mol% is preferable, and most preferably 25 mol% to 55 mol%. The saponification degree of the vinyl ester unit of EVOH is selected from the range of 90 mol% to 100 mol%, preferably 95 mol% to 100 mol%, more preferably 99 mol% to 100 mol%. When the degree of saponification is low, crystallization is lowered, gas barrier properties are lowered, and thermal stability at the time of melting may be deteriorated. Therefore, a higher degree of saponification is preferable. Here, vinyl acetate is a typical example of the vinyl ester, but other vinyl esters such as vinyl propionate, vinyl pivalate, vinyl valerate, vinyl caprate, vinyl benzoate and the like are also included. These vinyl esters may be used alone or in combination. EVOH may be used by mixing EVOH having at least one of ethylene content, saponification degree, and polymerization degree. EVOH may contain other copolymerization components as long as the object of the present invention is not impaired.

The non-adsorbing film 2 is a film formed from a mixed resin obtained by polymer alloying EVOH 82 wt% to 90 wt% and maleic anhydride-modified polyolefin polymer 10 wt% to 18 wt%.
In the composition ratio of the film, when the EVOH content is less than 82% by weight, the non-adsorption property of the film is deteriorated, and when the EVOH content exceeds 90% by weight, the heat sealability of the film is deteriorated. Absent.

The maleic anhydride-modified polyolefin polymer is obtained by grafting maleic anhydride onto an olefin polymer or copolymer. As an olefin polymer or copolymer (referred to herein as polyolefin or polyolefin resin), polyethylene {low density polyethylene (LDPE), linear low density polyethylene (LLDPE), ultra low density polyethylene (ULDPE) , High density polyethylene (HDPE)}, ethylene-vinyl acetate copolymer, ethylene- (meth) acrylic acid copolymer, ethylene- (meth) acrylic acid ester (methyl ester or ethyl ester) copolymer, and polypropylene are suitable. Polyethylene is preferred.

Film 2 formed from a mixed resin obtained by polymer alloying EVOH 82 wt% to 90 wt% and maleic anhydride-modified polyolefin polymer 10 wt% to 18 wt% has thermal adhesiveness, It has the characteristic that it is difficult to adsorb medicinal ingredients.

A film 2 formed from a mixed resin obtained by polymer alloying EVOH 82 wt% to 90 wt% and maleic anhydride-modified polyolefin polymer 10 wt% to 18 wt% can be produced, for example, by the method described below. Can do.

82% by weight to 90% by weight of ethylene-vinyl alcohol copolymer and 10% by weight to 18% by weight of maleic anhydride-modified polyolefin polymer are melt-mixed at a specific energy of 2.2 MJ / Kg or more, and then manufactured. Film. The range of specific energy at the time of melt mixing is preferably 2.7 MJ / Kg or more and 12.1 MJ / Kg or less. When 82 wt% to 90 wt% of ethylene-vinyl alcohol copolymer and 10 wt% to 18 wt% of maleic anhydride-modified polyolefin polymer are melt-mixed at a specific energy of less than 2.2 MJ / Kg, The resin does not mix evenly. If the specific energy exceeds 12.5 MJ / Kg, the shear strength is too high, and depending on the type of resin used, it may be decomposed, which is not preferable.

The specific energy refers to the energy given from the melt-kneading equipment to the resin per unit weight (1 kg) during melt-kneading, and is a value obtained by the following formula. The larger the value, the higher the kneading effect. It will be.

Here, the torque, the kneader rotation speed, and the resin extrusion amount mean the following.
Torque: Force required to rotate the kneader screw Kneader rotation speed: Kneader motor rotation speed required to rotate the kneader screw per unit time Resin extrusion rate: Kneader per unit time Amount of resin extruded from

In a screw kneader with two or more axes, the screw shape and the resin extrusion amount affect the specific energy. The screw shape is a combination of a kneading part, a reverse flight part and / or a mixing part in the flight part, compared to the one using a general purpose screw only for the flight part (hereinafter referred to as a full flight type). It is desirable to use a material (hereinafter referred to as a high shear type).

The screw can be used alone or in combination with a screw consisting of a flight screw, a pineapple, and a kneading disk.

In addition to EVOH and acid-modified polyolefins, additives such as heat stabilizers, weathering stabilizers, lubricants, antistatic agents, nucleating agents, fillers, pigments, dyes, flame retardants, antiblocking agents, etc., that are usually used are included. May be.

The polymer alloy obtained by melt mixing is formed into a film using a molding machine such as a T-die or inflation. The thickness of the film can be about 10 μm to 100 μm, but 40 μm or more is preferable from the viewpoint of sealing strength.

In general, a film obtained by melt-mixing incompatible resin components and forming a film has a resin component with a high mixing ratio, that is, a base resin is dispersed in a sea state, and a resin component with a low compounding ratio is dispersed in an island shape. It is known to have a structure.

A film 2 formed from a mixed resin obtained by polymer alloying EVOH 82 wt% to 90 wt% and maleic anhydride modified polyolefin polymer 10 wt% to 18 wt% is composed of EVOH in a sea state and modified with maleic anhydride. The aspect ratio of the acid-modified polyolefin polymer having a structure in which a polyolefin polymer is dispersed in an island shape and dispersed in an island shape is in the range of 2.0 to 9.5. Preferably, it is the range of 2.2 or more and 9.3 or less.

When the aspect ratio of the maleic anhydride-modified polyolefin polymer formed in an island shape satisfies the condition of 2.0 to 9.5, the film 2 having thermal adhesiveness can be obtained. An aspect ratio outside this range is not preferable because the thermal adhesiveness of the film is lowered.

“Has thermal adhesiveness” means that the adhesive strength between the films is 1.5 N / 15 mm or more when the films are bonded at 130 ° C., 0.2 MPa, and 0.7 seconds. . If it is less than this intensity | strength, the said film cannot fully adhere | attach.

Also, a film formed from a mixed resin obtained by polymer alloying EVOH 82 wt% to 90 wt% and maleic anhydride-modified polyolefin polymer 10 wt% to 18 wt%, wherein EVOH is seawater, anhydrous A film having a structure in which a maleic acid-modified polyolefin polymer is dispersed in islands and the aspect ratio of the acid-modified polyolefin polymer dispersed and distributed in islands is in the range of 2.0 to 9.5. In addition to thermal adhesiveness, it has non-adsorptive properties such as aroma (hereinafter abbreviated as non-adsorptive).
In the present invention, non-adsorptive means the property of not adsorbing volatile components such as menthol, limonene, methyl salicylate, camphor, tocopherol, wasabi, mustard, and other fragrance components of food such as mustard. The property which can maintain an aroma component. In the present specification, non-adsorptive means that the menthol weight value (mg) adsorbed by the film exposed to menthol vapor for 1 week is below the measurement limit.

As described above, the film formed from the mixed resin obtained by polymerizing EVOH 82 wt% to 90 wt% and maleic anhydride-modified polyolefin polymer 10 wt% to 18 wt% has thermal adhesiveness. It is a non-adsorbing film.

The thermal adhesive layer 31 is a film made of a resin containing a polyolefin resin and a maleic anhydride-modified polyolefin polymer, and the polyolefin resin is preferably polyethylene. The blending ratio of the maleic anhydride-modified polyolefin polymer is preferably 80% by weight or less based on the polyolefin resin. When the blending ratio of the maleic anhydride-modified polyolefin polymer exceeds 80% by weight with respect to the polyolefin resin, it is not preferable because blocking of the functional film occurs. The thermal adhesive layer 31 can be obtained by dry blending the polyolefin resin having the above blending ratio and the maleic anhydride-modified polyolefin polymer to form a film.

As described above, the functional film 3 has a characteristic of adsorbing gas components and moisture. When the film 32 of the functional film 3 is a hygroscopic film, for example, a mixed resin containing a mixture of a desiccant such as zeolite and polyolefin, a polyethylene resin, and a maleic anhydride-modified polyolefin polymer. The functional film 3 having hygroscopicity can be obtained by laminating layers by a multilayer film forming method. In addition, although the kind of resin mentioned above can be used for polyolefin, polyethylene is used suitably.
In the case of an oxygen-absorbing film, for example, an oxygen absorbent composed of a mixture of gallic acid and a transition metal compound, and a mixed resin containing a polyethylene resin and a maleic anhydride-modified polyolefin polymer are laminated by a multilayer film forming method. Thus, the functional film 3 having oxygen absorbability can be obtained.

The functional film 3 including the heat bonding layer 31 and the adsorption layer 32 may be laminated by a multilayer film forming method.

Further, an aluminum-deposited PET film or the like may be further laminated on the film 32 by an extrusion laminating method or a dry laminating method.

The non-adsorbable film 2 having thermal adhesiveness and the thermal adhesive layer 31 of the functional film 3 are faced to each other and heat-sealed on each side or four sides to form a three-sided bag, a four-sided bag, a gusseted bag, or the like. .

[Embodiment 2]
The non-adsorptive film 2 having thermal adhesiveness described in the first embodiment is a single layer film, but may be a multilayer film 2 ′. As shown in FIG. 2, the multilayer film 2 ′ is obtained by laminating a metal foil laminated PET film 2 a on a non-adsorbing film 2 having thermal adhesiveness by a laminating method.

[Embodiment 3]
In the present embodiment, an example will be described in which the medicinal component patch is housed in the packaging bags of the first and second embodiments (see FIG. 3).
Generally, in the medicinal component patch, the medicinal component layer B applied to the support A is coated with a coating material C such as a plastic film. In such a medicinal component patch, the medicinal component tends to volatilize from the support A side of the medicinal component patch. Therefore, if the non-adsorptive film 2 is disposed on the base material A side, the functional film 3 is disposed on the covering material C side, and the medicinal component patch is enclosed in the packaging bag of the present invention, the volatilization of the medicinal component is prevented. In addition, the film 32 can keep the water content or oxygen content in the packaging bag constant.

[Production and evaluation of non-adsorptive film having adhesive properties]

Table 1 shows the production conditions and evaluation results of non-adsorbable films having thermal adhesiveness (in the examples, described as non-adsorbable films) and comparative films (comparative films 1 to 9).

EVOH and maleic anhydride-modified polyolefin are blended in the proportions shown in Table 1, and the specific energy shown in Table 1 is obtained using a L / D = 30 twin screw extruder (lab blast mill, Toyo Seiki Seisakusho Co., Ltd.). And melt mixed in a twin screw extruder.

EVOH uses Eval F104B and Eval E105B (both made by Kuraray Co., Ltd.), and in non-adsorbing films 1 to 9 and 12 and comparative films 1 to 8, a mixture of 4: 6 is used. As the non-adsorbing films 10 and 11 and the comparative film 9, Eval E105B was used alone.

Maleic anhydride-modified polyethylene was used as the maleic anhydride-modified polyolefin. The LDPE system in the table is modic DL2400 (MFR is 3.0 g / 10 min), the HDPE system is modic DH4200 (MFR is 0.6 g / 10 min), or the LLDPE system is modic DU6400 (MFR is 1.7 g / 10 min). (Each manufactured by Mitsubishi Chemical Corporation) was used.

Melting and mixing was performed using a twin screw extruder (Labplast Mill, Toyo Seiki Seisakusho Co., Ltd.) having an L / D = 30 screw equipped with a flight screw, pineapple, and a kneading disk. In addition, L means the effective length of a screw and D means the diameter of a screw.

A polymer alloy obtained by melt mixing was formed into a film with a T-die to produce a sealant film having a thickness of 40 μm. The sealant film had a structure in which EVOH was formed in a sea state and an acid-modified polyolefin polymer having a low blending ratio was dispersed in an island shape.

The aspect ratio, thermal adhesiveness and menthol adsorption amount of the non-adsorbed film and the film obtained from the comparative film were measured by the following methods. The results are shown in Table 1 above.

[Aspect ratio measurement method]
An atomic force microscope image was analyzed, and an average value of the ratio of the major axis to the minor axis of the maleic anhydride-modified polyolefin particles forming and distributing islands was defined as the aspect ratio. Image analysis was performed by MOUNTECH, an image analysis type particle size distribution measurement software Mac-View ver. Measured using 4.0. The aspect ratio and area are automatically measured. Calculated as the average value of 100 or more particles in the image. However, particles smaller than 0.2 square micrometers were excluded as noise.

[Measurement method of thermal adhesiveness (seal strength)]
As a reinforcing film, a biaxially stretched PET film (thickness 25 μm) is dry laminated on each non-adsorbing film and each comparative film, and the film surfaces of each non-adsorbing film and each comparative film are combined at 130 ° C. Heat sealing was performed under the conditions of 2 MPa and 0.7 sec. The adhesive strength of 15 mm width of the heat seal part was measured by a T-type peel test based on JIS Z 0238. Those that peeled off with a slight strength during the preparation of a peel test sample were considered to be unmeasurable (ND).

[Measurement method of menthol adsorption]
Each non-adsorbed film and each comparative film (100 mm × 100 mm) was exposed to menthol vapor generated at 40 ° C. for one week. Menthol adsorbed on the film was extracted with methyl ethyl ketone, and the amount of adsorption was quantified by gas chromatography. A trace amount (less than 0.05 mg) that could not be quantified was regarded as undetectable (ND).

From the comparative films 1 to 6 and 9, the thermal adhesiveness of the film in which the blending ratio of maleic anhydride-modified polyolefin is less than 10% by weight or more than 18% by weight is 1.5 N / 15 mm or less, which is said to be a practical level. I understand.

However, as in Comparative Films 7 and 8, even when the blending ratio of the maleic anhydride-modified polyolefin is 15% by weight, the seal strength may be 0.67 N / 15 mm or less and lower than 1.5 N / 15 mm. It was. It can be seen that the films of the comparative films 7 and 8 have a lower aspect ratio of the maleic anhydride-modified polyolefin than the non-adsorbed films 1 to 12.

From the above, the heat sealability of the sealant film formed from a polymer alloy obtained by melt-mixing EVOH and maleic anhydride-modified polyolefin is as follows: blending ratio of EVOH and maleic anhydride-modified polyolefin and maleic anhydride-modified polyolefin It was found that the aspect ratio of both had an effect.

That is, it can be seen that a sealant film formed from a polymer alloy obtained by melt-mixing EVOH and maleic anhydride-modified polyolefin must satisfy the following conditions.
(1) A resin composition comprising 82% by weight to 90% by weight of an ethylene-vinyl alcohol copolymer and 10% by weight to 18% by weight of a maleic anhydride-modified polyolefin polymer.
(2) The aspect ratio of the maleic anhydride-modified polyolefin particles distributed in the form of islands in the ethylene-vinyl alcohol copolymer forming the sea structure is in the range of 2.0 to 9.5.

The aspect ratio of the maleic anhydride modified polyolefin particles is the ratio given when melt mixing EVOH and maleic anhydride modified polyolefin when the blending amount of the ethylene-vinyl alcohol copolymer and the maleic anhydride modified polyolefin is within the above range. It can be controlled by energy. The aspect ratio can be controlled by MFR (melt flow rate), melt mixing time, winding speed after film extrusion, etc. of the maleic anhydride-modified polyolefin polymer.

From Table 1, the resin was melt mixed with a specific energy of 2.2 MJ / Kg or more, preferably 2.7 MJ / Kg or more and 12.1 MJ / Kg or less, and the aspect ratio of the maleic anhydride-modified polyolefin particles of the obtained film It can be seen that heat sealability at a practical level can be obtained by setting the value in a range of 2.0 to 9.5.

The non-adsorptive property of the aroma tends to worsen when the blending ratio of the acid-modified polyolefin polymer is increased, but no menthol absorption was detected in the non-adsorbed films 1 to 12 (N. D.). That is, the amount of menthol absorbed is comparable to the EVOH single film.

[Manufacture and evaluation of packaging bags]
(Examples 1 to 8, Comparative Examples 1 to 3)
A polymer alloy obtained by melting and mixing 88 parts of Eval E171B (Kuraray) and 12 parts of Modic DU6400 (Mitsubishi Chemical) at a specific energy of 5.6 MJ / kg was formed into a film having a thickness of 20 μm by using a T die (Aspect) Ratio 2.59, menthol adsorption ND). This film was further laminated with PET (thickness 12 μm) / AL foil (thickness 9 μm) to obtain a non-adsorbing film.
LLDPE (Evolue SP2520, manufactured by Prime Polymer) and maleic anhydride-modified LLDPE (Modic DU6400, manufactured by Mitsubishi Chemical) at a ratio shown in Table 2, LDPE (Petrocene 204, manufactured by Tosoh) and zeolite in a weight ratio of 1: The resin mixture blended in 1 was laminated with a multilayer inflation film forming apparatus (LLDPE and maleic anhydride modified LLDPE layer thickness 10 μm / LDPE layer thickness including zeolite 50 μm), and PET (thickness 12 μm) / AL foil ( A functional film was obtained by laminating a thickness of 9 μm).

(Comparative Examples 4 to 6)
Instead of the non-adsorptive films of Examples 1 to 8, Kuraray heat seal EVOH film (Eval E30, Kuraray, thickness 30 μm) and PET (thickness 12 μm) / AL foil (thickness 9 μm) are laminated. Thus, a non-adsorbing film was obtained. LLDPE (Evolue SP2520, manufactured by Prime Polymer) and maleic anhydride-modified LLDPE (Modic DU6400 manufactured by Mitsubishi Chemical) at a ratio shown in Table 2, LDPE (Petrocene 204, manufactured by Tosoh) and zeolite in a weight ratio of 1: 1. The resin mixture blended in (1) was laminated with a multilayer inflation film forming apparatus, and further a PET (thickness 12 μm) / AL foil (thickness 9 μm) was laminated to obtain a functional film.

(Comparative Examples 7 to 9)
Instead of the non-adsorptive films of Examples 1 to 8, an acrylonitrile resin film (Hitron BX, Tamapoly) and PET (thickness 12 μm) / AL foil (thickness 9 μm) were laminated to form a non-adsorptive film. LLDPE (Evolue SP2520, manufactured by Prime Polymer) and maleic anhydride-modified LLDPE (Modic DU6400, manufactured by Mitsubishi Chemical) at a ratio shown in Table 2, LDPE (Petrocene 204, manufactured by Tosoh) and zeolite in a weight ratio of 1: The resin mixture blended in 1 was laminated with a multilayer inflation film forming apparatus, and further a PET (thickness 12 μm) / AL foil (thickness 9 μm) was laminated to obtain a functional film.

The non-adsorbing film and the thermal adhesive layer of the functional film were faced to each other, and the four sides were heat sealed at 160 ° C., 180 ° C. and 200 ° C., and the thermal adhesiveness (seal strength) of the resulting packaging bag was measured. . The thermal adhesiveness was measured with a T-type peel tester (STROGRAPE VE10D manufactured by Toyo Seiki Co., Ltd.) based on JIS Z 0238 for the seal strength of 15 mm width of the seal part. The measurement conditions are as follows.
Distance between chucks: 10 mm, tensile speed: 300 mm / min
The results of heat seal strength are shown in Table 2. The evaluation is “◯” for 5N / 15mm or more, “△” for 2N / 15mm to less than 5N / 15mm, “▲” for 1N / 15mm to less than 2N / 15mm, “×” for less than 1N / 15mm. Is shown.

As described above, a functional film in which a metal vapor deposition film is laminated on the opposite surface of the thermal adhesive layer may be used. When laminating a metal vapor-deposited film, first, a polyethylene (PE) layer laminated on the opposite side of the thermal adhesive layer of the functional film is wound on a roll, and then a PET / metal foil laminate film is laminated on the PE layer. Is done. However, when the film is wound, the thermal bonding layer and the PE layer are overlapped, and blocking is likely to occur.

LLDPE (Evolue SP2520, manufactured by Prime Polymer) and maleic anhydride-modified LLDPE (Modic DU6400, manufactured by Mitsubishi Chemical) at a ratio shown in Table 2, LDPE (Petrocene 204, manufactured by Tosoh) and zeolite in a weight ratio of 1: The resin mixture blended in 1 was laminated with a multilayer inflation film forming apparatus.
A PE layer (10 μm) is laminated on the above functional film (LLDPE and maleic anhydride modified LLDP layer thickness 10 μm / LDPE layer thickness 50 μm containing zeolite), and the PE layer and the thermal adhesive layer are combined to 1 kgf / cm. A load of ² was applied, and the mixture was allowed to stand for 24 hours in an environment of 23 ° C. and a relative humidity Rh of 50%, and then the blocking property was evaluated using a blocking tester. The results are shown in Table 2. A case where the film is completely peeled is represented by “◯”, a state where a part is adhered is represented by “Δ”, and a case where the entire surface is adhered is represented by “X”.

When a film made of a mixed resin of polyethylene and maleic anhydride modified polyethylene resin is used for the thermal adhesive layer of the functional film, if the non-adsorbing film is a material other than the mixed resin of EVOH and maleic anhydride modified polyethylene, the sealing strength It can be seen that the thermal adhesiveness of the non-adsorptive film does not occur. Moreover, it turns out that it will become easy to generate | occur | produce blocking at the time of film forming and film winding, if the amount of acid-modified resin contained in the heat bonding layer of a functional film increases. In particular, it can be seen that when the maleic anhydride-modified polyethylene resin is contained in 90% by weight or more of polyethylene, the functional film is likely to be blocked.

(Examples 9 to 17, Comparative Examples 10 to 12)
The resin composition and blending ratio of the thermal adhesive layer of the functional film were changed to the ratios shown in Table 3, and the sealing strength and blocking of the packaging bag were evaluated. The results are shown in Table 3. Evolu SP2520 (manufactured by Prime Polymer) is LLDPE, and Mersen MX02 (manufactured by Tosoh) is an ethylene-vinyl acetate copolymer compound resin. Modic DL2400 (Mitsubishi Chemical) and Modic DU6400 (Mitsubishi Chemical) are maleic anhydride-modified PE.
PET (thickness 12 μm) / AL vapor deposition film (thickness 9 μm) and non-adsorbing film laminated on the thermal adhesive layer of the functional film are the same as in Examples 1-8.

As with the results shown in Table 2, it can be seen that the mixing ratio of polyethylene and maleic anhydride-modified polyethylene resin affects the blocking of the functional film.

(Hygroscopicity test of functional film)
The functional films of Comparative Examples 1 to 3 and Example 8 were cut into 100 mm × 100 mm squares, absorbed in a constant temperature and humidity chamber in an environment of 40 ° C. and relative humidity Rh of 90%, and the change in weight was measured over time. The amount of moisture absorption was determined. The results are shown in FIG. The ones added with maleic anhydride-modified polyethylene (Comparative Examples 1 and 2 and Example 8) have the same hygroscopic performance as the additive-free hygroscopic film (Comparative Example 3), and even when maleic anhydride-modified polyethylene is added. It can be seen that the moisture absorption characteristics are not impaired.

DESCRIPTION OF SYMBOLS 1, 1 ': Packaging bag 2: Nonadsorbent film which has heat adhesiveness 2': Nonadsorbable multilayer film which has heat adhesiveness 2a: Metal foil laminated PET film 3: Functional film 31: Heat of functional film Adhesive layer 32: Adsorbing layer of functional film A: Support for medicinal component patch B: Medicinal component layer of medicinal component patch C: Coating material for medicinal component patch

Claims

A non-adsorptive film having thermal adhesiveness comprising 82% by weight to 90% by weight of an ethylene-vinyl alcohol copolymer and 10% by weight to 18% by weight of a maleic anhydride-modified polyolefin polymer; and 80% by weight to 20% A functional film including a thermal adhesive layer made of 20% by weight to 80% by weight of a maleic anhydride-modified polyolefin polymer, the non-adsorbing film, and the thermal adhesive layer of the functional film, Is a packaging bag that is heat sealed and formed into a bag shape.
The non-adsorptive film has a structure in which a maleic anhydride-modified polyolefin polymer is dispersed in islands, and the aspect ratio of the acid-modified polyolefin polymer dispersed and distributed in islands is 2.0-9. The packaging bag of claim 1 in the range of .5.
The packaging bag according to claim 2, wherein the non-adsorbing film is a film formed from a mixed resin obtained by polymer-alloying an ethylene-vinyl alcohol copolymer and a maleic anhydride-modified polyolefin polymer.
The packaging bag according to claim 1, wherein the thermal adhesive layer is a film formed of a mixed resin containing a polyolefin resin and a maleic anhydride-modified polyolefin resin.
The packaging bag according to claim 4, wherein the maleic anhydride-modified polyolefin resin is 80% by weight or less based on the polyolefin resin.