WO2014107664A1 - Compositions et procédés de lutte contre une infestation d'acariens parasites des abeilles domestiques - Google Patents

Compositions et procédés de lutte contre une infestation d'acariens parasites des abeilles domestiques Download PDF

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Publication number
WO2014107664A1
WO2014107664A1 PCT/US2014/010347 US2014010347W WO2014107664A1 WO 2014107664 A1 WO2014107664 A1 WO 2014107664A1 US 2014010347 W US2014010347 W US 2014010347W WO 2014107664 A1 WO2014107664 A1 WO 2014107664A1
Authority
WO
WIPO (PCT)
Prior art keywords
hop
strip
hive
corrugated
acids
Prior art date
Application number
PCT/US2014/010347
Other languages
English (en)
Inventor
Gene Probasco
Lloyd Schantz
Mark M. Bossert
Original Assignee
John I. Haas, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John I. Haas, Inc. filed Critical John I. Haas, Inc.
Priority to EP14735165.4A priority Critical patent/EP2941123A4/fr
Priority to CA2897371A priority patent/CA2897371C/fr
Priority to AU2014203897A priority patent/AU2014203897A1/en
Priority to US14/758,392 priority patent/US9545110B2/en
Priority to BR112015016129A priority patent/BR112015016129A2/pt
Publication of WO2014107664A1 publication Critical patent/WO2014107664A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K47/00—Beehives
    • A01K47/04—Artificial honeycombs
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K51/00—Appliances for treating beehives or parts thereof, e.g. for cleaning or disinfecting
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M1/00—Stationary means for catching or killing insects
    • A01M1/20—Poisoning, narcotising, or burning insects
    • A01M1/2005—Poisoning insects using bait stations
    • A01M1/2011—Poisoning insects using bait stations for crawling insects
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M1/00—Stationary means for catching or killing insects
    • A01M1/20—Poisoning, narcotising, or burning insects
    • A01M1/2022—Poisoning or narcotising insects by vaporising an insecticide
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M1/00—Stationary means for catching or killing insects
    • A01M1/20—Poisoning, narcotising, or burning insects
    • A01M1/2022—Poisoning or narcotising insects by vaporising an insecticide
    • A01M1/2027—Poisoning or narcotising insects by vaporising an insecticide without heating
    • A01M1/2055—Holders or dispensers for solid, gelified or impregnated insecticide, e.g. volatile blocks or impregnated pads
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]

Definitions

  • the invention features a method of reducing a honey bee parasitic mite infestation in a honey bee hive, the method comprising contacting a hive with the corrugated strip of any of the above- aspects, thereby reducing a bee parasitic mite infestation in the hive.
  • the method involves providing 2 corrugated strips/10 frames.
  • the corrugated strips are hung from a frame within the hive.
  • the invention features a kit for the treatment or prevention of a parasitic mite infestation, the kit comprising the strip of any the above-aspects or any other embodiment of the invention delineated herein.
  • the strip is packaged in a moisture resistant material.
  • an effective amount of a miticide is meant an amount effective to disrupt a mite biological function.
  • honey bee is meant a Hymenopteran insect of the genus Apis.
  • honey bee is not limited to the adult form of the insect, but encompasses all honey bee developmental stages, including but not limited to egg, larva, and pupa.
  • honey bee parasitic mite any acarid that parasitizes a honey bee or infests a honey bee hive.
  • honey bee parasitic mites include Varroa mites and tracheal mites.
  • Figure 2 is a graph showing beta acids per bee measured over a 10-day course of treatment with standard HopGuard® or HopGuard II®®.
  • Products used to control honey bee parasitic mite infestation reduce, stabilize, or slow the growth of a mite population in a hive or inhibit the growth, survival, reproduction, or other biological function of a honey bee parasitic mite.
  • the miticide kills the mite.
  • Methods for measuring parasitic mite infestation are known in the art.
  • the sampled bees are killed with a wash of alcohol or soapy water and the sample poured through a double strainer.
  • a coarse mesh catches the bees but allows the mites to pass through, while a second finer screen catches the mites and allows the liquid to flow away. The mites present in the sample are then counted.
  • a miticide of the invention reduces the level of infestation in a hive by at least 10%, 25%, 50%, 75% or even by 100%.
  • a miticide of the invention induces at least 50%, 60%, or 70% increase in mite drop relative to an untreated hive.
  • the miticide induces 75%, 80%, 90%, or even 95% or 100% increase in mite drop relative to the level prior to treatment. Screening methods are used to identify concentrations of hop derivatives that will be lethal to a mite (e.g., induce at least 70% mite lethality) while minimizing lethal effects on adult bees.
  • Miticides of the invention contain concentrations of hop derivatives that have few or no adverse effects on honey bees during any of their life stages, but are effective in killing or disrupting the biological functioning of a mite.
  • beta acids a hop derivative
  • delivered at 4% concentration killed 87% of exposed mites after four hours while causing 0% lethality in adult bees.
  • mites are exposed to varying concentrations of hop derivatives to identify those concentrations that kill 50% to 100% of the exposed mite.
  • Adult honey bees are then exposed to concentrations of hop derivatives having miticidal activity to identify those that have a minimal effect on honey bee survival.
  • At least 75%, 80%, 85%, 90%, 95%, or 100% of adult bees will survive following exposure to a miticidal composition.
  • the effect of hop derivatives on mite and honey bee reproduction is assessed. Screening assays are used to determine the concentration of a miticide that reduces the number of eggs laid by the female mite, reduces the number of eggs that hatch, or reduces the number of mites that grow to reproductive maturity; preferably, the reduction is by at least 25%, 50%, 75%, 85%, 95% or 100%.
  • Hop Derivatives are used to determine the concentration of a miticide that reduces the number of eggs laid by the female mite, reduces the number of eggs that hatch, or reduces the number of mites that grow to reproductive maturity; preferably, the reduction is by at least 25%, 50%, 75%, 85%, 95% or 100%.
  • a hop derivative is a compound that occurs naturally in a hop plant (Humulus lupulus) or is chemically derived (either through natural biosynthetic procesess (e.g., living organism metabolism (e.g., mammal, plant, bacteria)) or by synthetic processes using human intervention (e.g., chemical synthesis).
  • Compositions of the invention include one or more compounds derived from hops.
  • hop acids Of particular interest are the hop acids. Hops contain two major organic acid classes, alpha acids and beta acids. Hop acids are the bitter acid components of hops that are used in beer making.
  • the compounds of this invention may contain one or more asymmetric centers and thus occur as racemates and racemic mixtures, single enantiomers, individual diastereomers and diastereomeric mixtures. All such isomeric forms of these compounds are expressly included in the present invention.
  • the compounds of this invention may also be represented in multiple tautomeric forms, in such instances, the invention expressly includes all tautomeric forms of the compounds described herein. All such isomeric forms of such compounds are expressly included in the present invention. All crystal forms of the compounds described herein are expressly included in the present invention.
  • the compounds of this invention, including the compounds of formulae described herein are defined to include derivatives. Derivatives include compounds of the invention that are modified by appending appropriate functionalities to enhance desired properties.
  • the amount of active ingredient e.g., hop acid alkali metal salts, hop acid alkaline earth metal salts or combinations thereof
  • carrier materials e.g., maltodextrin, cluster dextrin, corn starch, corn syrup solids, glucose, cyclodextrin, arabic gum, calaginan, inuline, partially hydrogenated soybean oil, cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, rosin, hypomellose
  • carrier materials e.g., maltodextrin, cluster dextrin, corn starch, corn syrup solids, glucose, cyclodextrin, arabic gum, calaginan, inuline, partially hydrogenated soybean oil, cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, rosin, hypomellose
  • miticides of the invention are formulated as liquids using diluents (e.g., sucrose or glucose solutions, water, juices, other aqueous solutions, water miscible solvents (ethanol, cremophor, dimethylsulf oxide (DMSO), dimethylformamide (DMF), isopropanol (IP A) or glycerol, and other solvents)) to form a solution or slurry.
  • diluents e.g., sucrose or glucose solutions, water, juices, other aqueous solutions, water miscible solvents (ethanol, cremophor, dimethylsulf oxide (DMSO), dimethylformamide (DMF), isopropanol (IP A) or glycerol, and other solvents
  • a typical miticidal preparation will contain from about 1% to about 95% hop acid, where the bottom of the range is any integer between 5 and 94 and the top of the range is any integer between 6 and 95, where the hop acids are provided in a carrier (e.g., maltodextrin, cluster dextrin, corn starch, corn syrup solids, glucose, cyclodextrin, arabic gum, calaginan, inuline, rosin, partially hydrogenated soybean oil, cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hypomellose) that is suitable for use in methods of producing a product having miticidal activity.
  • a carrier e.g., maltodextrin, cluster dextrin, corn starch, corn syrup solids, glucose, cyclodextrin, arabic gum, calaginan, inuline, rosin, partially hydrogenated soybean oil, cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxy
  • compositions of the invention include at least about 1%, 10%, 20%, 30%, 50%, 60%, 75%, 80%, 90%, or 95% hop acid alkali metal (e.g., sodium, potassium, lithium) or hop acid alkaline earth metal salts (e.g., calcium, magnesium) in a diluent or carrier. Not all of the hop acids need be in the metal form.
  • hop acid alkali metal e.g., sodium, potassium, lithium
  • hop acid alkaline earth metal salts e.g., calcium, magnesium
  • a composition of the invention contains hop acids where 90% are present in the metal form and 10% are present in the acid form; 50% are present in the metal form and 50% in the acid form; and 10% are present in the metal form and 90% in the acid form.
  • the preparation includes between 1 and 95% (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 25%, 75%, 80%, 90%, 95%) hop acids in a carrier or diluent. Alternatively, such preparations contain from about 20% to about 80% hop acids.
  • Compositions containing alpha or beta acids are manufactured by ordinary methods.
  • compositions of the invention are also useful for preventing the establishment of an acarid infestation, for treating an established acarid infestation, and for maintaining the health of a hive previously treated for an acarid infestation.
  • the composition of the invention is active in the hive for at least forty-one days. This provides for the presence of the miticide for the entirety of the mite life cycle, which typically is completed over the course of twenty-one to thirty days. Where activity is maintained for a shorter period (e.g., seven, fourteen, twenty- one, or thirty days), repeated administration of a composition of the invention may be desired or required. Compositions that are active for longer periods (e.g., two, three, six, nine, or twelve months) are also envisioned. Such compositions may be used for the long-term treatment or prevention of a mite infestation.
  • hop beta acids are dispersed in a propylene glycol solvent with polysorbate-60 added as an emulsifier.
  • Biodegradable corrugated strips comprising the emulsions are then delivered to the hive.
  • the corrugated strips are moistened by contacting them with hop beta acid resins, propylene glycol and polysorbate-60.
  • the powdered mixture is delivered to the hive within a semi-permeable pouch that resembles a "teabag".
  • the bees rip up the pouch, thereby releasing the powder.
  • the powdered hop acids get onto the body of the adult bees and are distributed throughout the hive, thereby killing (or otherwise interfering with mite proliferation or survival) mites present on the bees and inhibiting the mite infestation.
  • Alcohols such as glycerin and complex carbohydrates, such as starches may also be used as the "sweetener" ingredient.
  • the sweetener is used primarily as an attractant for the insects, however the sweetener also helps to impart a granular structure to the tablets, especially when the sweetener is a sugar. As previously discussed, this granular structure permits the tablet to crumble over time upon the exertion of sufficient forces.

Abstract

La présente invention concerne des procédés et des compositions pour lutter contre un acarien parasite de l'abeille domestique ou pour traiter ou prévenir une infestation d'acariens parasites dans une ruche d'abeilles domestiques. Dans des modes de réalisation particuliers, l'invention concerne un dispositif de distribution d'acaricide, le dispositif étant une bande ondulée comprenant une composition liquide contenant au moins environ 15 % de sels de potassium d'acides bêta de houblon, du solvant et un émulsifiant.
PCT/US2014/010347 2013-01-07 2014-01-06 Compositions et procédés de lutte contre une infestation d'acariens parasites des abeilles domestiques WO2014107664A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP14735165.4A EP2941123A4 (fr) 2013-01-07 2014-01-06 Compositions et procédés de lutte contre une infestation d'acariens parasites des abeilles domestiques
CA2897371A CA2897371C (fr) 2013-01-07 2014-01-06 Compositions et procedes de lutte contre une infestation d'acariens parasites des abeilles domestiques
AU2014203897A AU2014203897A1 (en) 2013-01-07 2014-01-06 Compositions and methods for controlling a honey bee parasitic mite infestation
US14/758,392 US9545110B2 (en) 2013-01-07 2014-01-06 Compositions and methods for controlling a honey bee parasitic mite infestation
BR112015016129A BR112015016129A2 (pt) 2013-01-07 2014-01-06 tira ondulada para uso na redução de uma infestação por ácaro parasita da abelha melífera; tira ondulada preparada pela imersão de uma tira absorvente em uma composição líquida; embalagem de alumínio preparada pela imersão de uma tira absorvente ondulada em uma composição líquida; colmeia feita pelo homem; produto da abelha melífera; método de redução de uma infestação por ácaro parasita da abelha melífera em uma colmeia de abelhas melíferas; e kit para o tratamento ou prevenção de uma infestação por ácaro parasita

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361749727P 2013-01-07 2013-01-07
US61/749,727 2013-01-07

Publications (1)

Publication Number Publication Date
WO2014107664A1 true WO2014107664A1 (fr) 2014-07-10

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PCT/US2014/010347 WO2014107664A1 (fr) 2013-01-07 2014-01-06 Compositions et procédés de lutte contre une infestation d'acariens parasites des abeilles domestiques

Country Status (6)

Country Link
US (1) US9545110B2 (fr)
EP (1) EP2941123A4 (fr)
AU (1) AU2014203897A1 (fr)
BR (1) BR112015016129A2 (fr)
CA (1) CA2897371C (fr)
WO (1) WO2014107664A1 (fr)

Cited By (1)

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WO2017042240A1 (fr) * 2015-09-09 2017-03-16 Universität Hohenheim Sel de métal lithium destiné à être utilisé dans le traitement de l'infestation d'abeilles mellifères par des acariens varroa destructor

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US20210045383A1 (en) * 2018-03-12 2021-02-18 Paul Niemczura Organic metabolite compositions and methods of use as miticides for honey bees
ES1215109Y (es) * 2018-03-27 2018-09-26 Chicon Carnero Jose Paulino Regleta contenedora de acaricida
US11213025B1 (en) * 2018-05-04 2022-01-04 Nathaniel Burns Device for dispensing pesticides and/or parasiticides to rodents or other animals
CA3043388A1 (fr) 2018-05-14 2019-11-14 John I. Hass, Inc. Compositions et methodes de controle d'infestation d'un acarien parasitaire des abeilles domestiques
US11622975B2 (en) 2019-07-16 2023-04-11 The United States Of America, As Represented By The Secretary Of Agriculture Compositions and methods for improved honey bee health
DE102020130875A1 (de) 2020-10-02 2022-04-07 Interbran Nature Gmbh Freisetzungssystem zur Bekämpfung von Parasiten
WO2023137555A1 (fr) * 2022-01-21 2023-07-27 Nature Recombined Sciences Inc. Extraits de houblon aqueux et leur utilisation comme agents antimicrobiens

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WO2017042240A1 (fr) * 2015-09-09 2017-03-16 Universität Hohenheim Sel de métal lithium destiné à être utilisé dans le traitement de l'infestation d'abeilles mellifères par des acariens varroa destructor
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US11723366B2 (en) 2015-09-09 2023-08-15 Universität Hohenheim Alkali metal salt for use in treatment of Varroa destructor mite infestation of honey bees

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