WO2014084650A1 - Appareil de prélèvement d'échantillon de tissu biologique - Google Patents
Appareil de prélèvement d'échantillon de tissu biologique Download PDFInfo
- Publication number
- WO2014084650A1 WO2014084650A1 PCT/KR2013/010963 KR2013010963W WO2014084650A1 WO 2014084650 A1 WO2014084650 A1 WO 2014084650A1 KR 2013010963 W KR2013010963 W KR 2013010963W WO 2014084650 A1 WO2014084650 A1 WO 2014084650A1
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- WIPO (PCT)
- Prior art keywords
- tissue
- syringe
- needle assembly
- housing
- biological tissue
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
- A61B10/0275—Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0283—Pointed or sharp biopsy instruments with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe
Definitions
- the present invention relates to an apparatus for collecting biological tissues and a method of using the same, and more particularly, to an apparatus for collecting biological tissues and a method of using the same, which can simultaneously perform tissue collection and drug injection.
- Accurate diagnosis is essential before treatment because various types of tumors in the human body may differ from each other.
- the diagnosis of the tumor is diagnosed by detecting tumor cells in the tumor tissue. Since several types of tumors may occur even in the same region of the human body, it is necessary to confirm the type of tumor before treatment through a cell test.
- Methods for collecting tissue from tumor lesions include incision biopsies, which are taken directly after the incision of the skin, fine needle aspiration with a syringe, and total biopsy with a needle launch gun device (Gun Biopsy).
- the incision biopsy can obtain sufficient tissues, which can lead to high diagnostic accuracy, but it requires a lot of time and money for anesthesia and skin incision, and there is a problem that tumor cells are more likely to be contaminated around the incision without accurate and meticulous surgical techniques.
- the fine needle aspiration test using a syringe has a problem in that it is insufficient to make an accurate diagnosis because the patient is less uncomfortable and painless, or because the amount of tissue collected is very small.
- Total biopsy is a widely used method for diagnosing various cancers because more tissues can be obtained using a needle having a cutting surface, and thus the accuracy of the biopsy methods is relatively high.
- Figure 1 shows a perspective view showing a device 100 for biological tissue collection according to the conventional total histology.
- the apparatus 100 for collecting biological tissues according to the conventional biopsy technique includes a housing 110, a tube 120 extended by being coupled to the front end of the housing 110, and a biological tissue collected by being coupled to the front end of the tube 120. It consists of a needle assembly (130).
- the needle assembly 130 includes a front end 132 and a storage unit 134 in which tissue formed at the rear of the front end 132 is stored.
- the rear end of the housing 110 is provided with a firing button 112 to move the needle assembly 130 to the biopsy site and to advance the tube 120 along the moved needle.
- the tip portion of the tube 120 is provided with a cutting portion 122 for cutting the tissue.
- FIG. 2A to 2C illustrate a tissue collection process of the apparatus 100 for collecting biological tissues according to the prior art.
- tissue collection Penetrates the needle assembly 130 to the desired tissue site, and the tissue to be collected in the tissue is seated in the reservoir 134 of the needle assembly 130 (see arrow A in FIG. 2A).
- the firing button 112 provided at the rear end of the housing 110 is pressed once more, and as shown in FIG. 2B, the tube 120 is moved to the needle assembly 130. It moves up to the tip 132, whereby tissue is cut and stored in the reservoir 134 (see arrow B in FIG. 2B).
- the apparatus 100 for collecting the biological tissue of the prior art having such a configuration may cause bleeding from the insertion hole when the needle assembly 130 is inserted into the human body, thereby causing a bruise or blood accumulation of hematoma. There was a problem that could occur.
- the tissue is a malignant tumor
- the bleeding portion and the hematoma are considered to be contaminated with malignant tumor cells, and there is a problem that the range of excision during surgery or the limbs should be cut.
- cystic tumors containing only liquids and liquid and solid substances mixed heterogeneously inside the tumors of the human body there are cystic tumors containing only liquids and liquid and solid substances mixed heterogeneously inside the tumors of the human body, and in the case of liquid tumors, it is recommended to collect the biological tissues according to the prior art. There was a problem that it was not easy.
- the present invention has been made to solve the above-mentioned problems of the prior art, and provided with a storage unit for storing the cut tissue in the needle assembly of the apparatus for collecting biological tissue, and a suction hole for collecting liquid tissue, By providing an injection hole for injecting the drug into the wounded tissue at the lower end, it is possible to provide a biological tissue harvesting device capable of administering the drug to the site where the bleeding can occur while collecting the tissue with a single device.
- the lower end of the tube is provided with an injection hole for administering the drug into the wounded tissue in the longitudinal direction to allow for simultaneous tissue collection and drug injection in the human body, thereby preventing the spread of tumor or tissue cells, tissue It is to provide a biological tissue collection device that is easy to remove during surgery that can mark the test track (path for tissue collection into the human body) and the tumor site.
- the tissue to be collected is collected in a storage unit when the solid to be collected, the liquid tissue is to provide a biological tissue harvesting device that can be easily collected with a suction hole.
- the present invention to achieve this object is a housing; A firing button provided at the rear end of the housing; A tube extending from the front end of the housing and equipped with an injection hole for injecting the drug into the tissue along the length of the bottom; And a needle assembly which is installed to be movable to the histological examination site in the tube by a button, and cuts and stores solid tissue or sucks the liquid tissue.
- the cutting portion for cutting the tissue is formed at the front end of the needle assembly, characterized in that formed.
- the needle assembly is formed of one or more metals selected from the group consisting of Ti, Ni, Fe, Cr, Ta, stainless steel, and shape memory alloy.
- the tip end of the needle assembly is characterized in that the coating with one or more metals selected from the group consisting of Ti, Ni, Fe, Cr, Ta, stainless steel, and shape memory alloy.
- the cutting portion for cutting the tissue is formed at the tip of the tube, characterized in that formed.
- the present invention extends from the leading end of the needle assembly, characterized in that the reservoir for storing the cut tissue is formed.
- the needle assembly is characterized in that the suction hole is connected to the reservoir to suck the liquid tissue.
- the vertical cross section of the injection hole is characterized in that it is formed to have a circular, elliptical or inverted triangle shape.
- a plurality of side holes are formed on the outer surface of the injection hole.
- the drug injection syringe connected to the injection hole and the tissue suction syringe connected to the suction hole is characterized in that it is detachably provided inside the housing.
- the drug injection syringe and the tissue suction syringe is characterized by consisting of a hollow syringe body and a piston moving inside the syringe body.
- the slide button is coupled to the piston so that the drug injection syringe and the tissue suction syringe are slidable, respectively.
- the drug injection syringe and the tissue suction syringe is characterized by having a dose of 1 ⁇ 3cc.
- one or more fixing grooves are continuously formed on one surface of the housing in which the slide button is moved to slide the piston to a unit length, and then stop not moving in the direction of the firing button by pressure. do.
- a space portion formed in the housing, and one end is connected to the injection hole, characterized in that it comprises an extension tube accommodated in the space portion.
- the other end of the extension tube is exposed to the outside of the space portion to form a fastening portion.
- the cover which opens and closes a space part is characterized by the above-mentioned.
- the space portion formed in the housing, and one end is connected to the suction hole, characterized in that it comprises an extension tube accommodated in the space portion.
- the other end of the extension tube is exposed to the outside of the space portion to form a fastening portion.
- the cover which opens and closes a space part is characterized by the above-mentioned.
- the needle assembly of the biological tissue collecting device is provided with a storage unit for storing the cut tissue, and a suction hole for collecting liquid tissue, and the lower end of the tube contains a drug into the wounded tissue.
- the injection hole is provided, and the bleeding generated from the tumor and the histological track due to the tissue collection is administered by the injection hole in the site of the tumor cell contamination, so that the tissue collection and drug administration can be performed simultaneously with a single instrument.
- the tissue to be collected may be collected in a storage unit when the tissue to be collected is solid, and the liquid tissue may be easily collected by a suction hole.
- FIG. 1 is a perspective view showing a device for collecting biological tissue according to the prior art
- Figures 2a to 2c is a view showing the use of the apparatus for collecting biological tissue according to the prior art
- FIG. 3 is a perspective view showing a device for collecting biological tissue in one embodiment of the present invention.
- Figure 4 is a perspective view showing a device for collecting biological tissue according to another embodiment of the present invention.
- FIG. 5 is a perspective view showing a biological tissue collection device according to an embodiment of the present invention.
- FIG. 6 is a perspective view showing the action of the needle assembly according to FIG. 5;
- FIG. 7 to 12 is a perspective view showing a tissue collection process of the apparatus for collecting biological tissues according to the present invention.
- FIG. 13A to 13C are schematic views showing various shapes of the apparatus injection hole for collecting biological tissue of FIG. 7;
- FIG. 14A to 14D are schematic views showing various shapes of the device storage unit for collecting the biological tissue of FIG. 12;
- FIG. 15 is a perspective view of a biological tissue collection device according to another embodiment of the present invention.
- FIG. 16 is a plan view showing the action of the needle assembly according to FIG. 15;
- FIG. 17 is a perspective view showing a device for biological tissue collection according to another embodiment of the present invention.
- FIG. 18 is a perspective view showing an apparatus for collecting biological tissues according to another embodiment of the present invention.
- FIG. 19 is a perspective view illustrating a method for mounting the extension tube in FIG.
- FIG 3 is a perspective view showing a biological tissue collection device 200 according to the present invention.
- the biological tissue collecting device 200 includes a housing 210, a tube 220 coupled to an extended end of the housing 210, and a needle assembly 230 coupled to the tube 220 to collect biological tissue. It is composed of
- the rear end of the housing 210 has a firing button 212 for moving the tube 220 and the needle assembly 230, a first syringe 214 containing liquid tissue, a second syringe 216 containing a drug
- the first slide 215 is slidably coupled to the first syringe 214
- the second slide 217 is slidably coupled to the second syringe 216.
- Launch button 212 is formed of a two-stage button, a detailed description thereof will be described below.
- the first syringe 214 and the second syringe 216 are composed of hollow syringe bodies 214a and 216a and pistons 214b and 216b that move in the syringe bodies 214a and 216a. It is provided side by side inside the 210.
- a first slide coupled to one end of pistons 214b and 216b of the first syringe 214 and the second syringe 216 so that the first syringe 214 and the second syringe 216 are slidable.
- the 215 and the second slide 217 are detachably provided side by side inside the housing 210.
- the housing 210 is a portion that the user grips by hand, and the capacity of the first syringe 214 and the second syringe 216 preferably has a capacity of 1 kW or more.
- first syringe 214 and the second syringe 216 are as follows.
- the operation of the first syringe 214, the initial state of the first syringe 214 is the front end of the piston 214b of the first syringe 214 the syringe of the first syringe 214
- the piston 214b of the first syringe 214 is in contact with the tip of the body 214a.
- the tip and the tip of the syringe body 214a of the first syringe 214 are spaced apart from each other, so that liquid tissue is sucked into the syringe body 214a of the first syringe 214 (see FIG. 5). ).
- one or more fixing grooves 218 are continuously formed on one surface of the housing 210 in which the first slide 215 and the second slide 217 slide to slide the piston in the front-rear direction and then stop. After the pressure can be stopped so as not to move in the direction of the firing button, it can be operated in unit length.
- the shape of the fixing groove 218 is not particularly limited as long as it can prevent the piston (214b, 216b) from moving excessively in the direction of the needle assembly 230, in one preferred example, shown in the enlarged view of FIG.
- the fixing groove 218a may have a rack gear shape, which may prevent the pistons 214b and 216b of the syringes 214 and 216 from moving in the direction of the needle assembly 230.
- a plurality of fixing grooves 218b on one surface of the sliding housing 210 may be formed in a projection shape in the longitudinal direction, the projection shape fixed
- a fixing hole 219 that may be coupled to the groove 218b may be formed at the rear end of the first slide 215 or the second slide 217.
- the protrusion-shaped fixing groove 218b may be formed in a row or two rows according to the moving directions of the first syringe 215 and the second syringe 217, and may flow upward and downward when an external force is applied.
- the pistons 214b and 216b of the syringes 214 and 216 can move in the horizontal direction.
- the initial state of the second syringe 216 is the front end of the piston 216b of the second syringe 216 and the syringe body of the second syringe 216 ( 216a) the tips are spaced apart from each other, and the second slide 217 moves the tip of the piston 216b of the second syringe 216 to the tip of the syringe body 216a of the second syringe 216.
- the drug in the syringe body 216a of the second syringe 216 is a tissue extraction site of the tumor through the injection hole 222 by the pushing force of the piston 216b of the second syringe 216. And the bleeding portion of the biopsy track (see FIG. 6).
- 17 and 18 as another example of the apparatus for collecting biological tissue, may have a structure including at least one extension tube in place of the first and second syringes.
- the apparatus for collecting biological tissue is connected to the end of the space portion 412, one end of the suction hole 436 and / or injection hole 422 formed in the housing 410 and is received in the space portion It may be configured to include an extension tube (440, 440 ').
- one end of the extension tube 440 and 440' is connected to the end of the suction hole 436 and / or injection hole 422, respectively, the other end Fastening portions 442 and 442 ′ for exposing the syringe 460 or the general syringe 461 that are commonly used at the other end of the space 412 and exposed to the other end thereof may be formed.
- the integrated syringe 460 may be connected to the fastening portion 442, and by fastening the general syringe 461 to another fastening portion 442 ', suction or through the extension tube (440, 440') Drug injection may be possible.
- the extension tubes 440 and 440 ' are stored and stored in the space 412, and when the suction of liquid is required, the general syringe 461 is provided through the fastening portion 442'.
- the integrated syringe 460 loaded with drugs may be injected into the fastening part 440.
- extension tubes 440 and 440 ' may be connected to the end of the suction hole 436 or the injection hole 422 according to the intended use, and at the same time the ends of the suction hole 436 and the injection hole 422 Of course, you can connect and use.
- the type of drug injected into the integrated syringe 460 may vary, for example, may be an anticancer agent or a hemostatic agent, and the hemostatic agent is separately stored in the integrated syringe 460 and stored in a liquid state. If you coalesce with each other to coagulate can exhibit a hemostatic effect.
- fastening parts 442 and 442 'used in the present invention are universal connectors to which all types of syringes can be mounted, a variety of syringes can be easily and easily attached to the fastening parts 442 and 442'. I can attach it.
- the extension tube 440 is stored in the space 412 formed in the housing 410, the space The cover 450 coupled to the portion 412 may be stored inside the biological tissue collection device.
- the cover 450 is not particularly limited as long as it is a shape capable of opening and closing the space 412, but as a preferred example, may be formed integrally with the housing 410, the tip of the cover 450 The locking protrusion 452 having a predetermined size of the groove 454 is formed, and the locking protrusion 452 may be inserted into the hook 414 formed on one side of the space 412 to be closed.
- the space 412 is not particularly limited as long as it can have a predetermined depth and size to accommodate the extension tubes 440 and 440 '.
- FIG. 7 shows a perspective view of a biological tissue collection device 200 according to an embodiment of the present invention
- Figure 8 shows a plan view showing the action of the needle assembly 230 according to FIG.
- FIG. 7 to 8 is a biological tissue harvesting apparatus 200 according to an embodiment of the present invention shown in Figure 3, the housing 210, the tube 220 is coupled to the front end of the housing 210 and extended, and It is composed of a needle assembly 230 coupled to the tube 220 to collect biological tissue.
- the needle assembly 230 is formed at the front end portion 232, the rear end portion 232 of the storage portion 234 to store tissue, and the storage portion 234 connected to the first syringe 214 in liquid tissue.
- the suction hole 236 is collected.
- the tip portion 232 of the needle assembly 230 is not particularly limited as long as it is a needle shape having a cut surface, but preferably, the tip portion 232 of the needle assembly 230 may have a triangular pyramid shape.
- the needle assembly 230 may be formed of one or more metals selected from the group consisting of Ti, Ni, Fe, Cr, Ta, stainless steel, and shape memory alloys, in one preferred example, In another preferred example, it may be coated with one or more metals selected from the group consisting of Ti, Ni, Fe, Cr, Ta, stainless steel, and shape memory alloys.
- the formation recovery temperature varies according to the weight composition ratio of nickel and titanium. For example, when the shape recovery temperature is higher than room temperature, the shape memory effect appears at room temperature, and the shape recovery temperature is If it is lower than room temperature, there is a characteristic that the super elastic effect appears at room temperature.
- the superelastic alloy is deformed by applying a large deformation force such that plastic deformation is normal metal material, and when the deformation force is removed, it is restored to its original shape like rubber. Therefore, since there is a characteristic of maintaining the original shape even after collection without deformation or breakage due to the force collected during tissue collection, safety can be improved.
- the weight composition ratio of nickel and titanium is preferably 55:45 to 99: 1, and more preferably 55:45 to 65:35.
- the composition may be dissolved in a melt in a vacuum arc furnace to coat only the tip portion 232 of the needle assembly 230 to form the needle assembly 230 of the present invention.
- the molten nickel-titanium melt may be solidified into a plate shape and then processed to form the needle assembly 230 of the present invention.
- the tube 220 is composed of an injection hole 222 through which the drug flows and a cutting portion 224 for cutting the tissue, the injection hole 222 through which the drug flows in the longitudinal direction at the lower end of the tube 220 It is provided with.
- the vertical cross-sectional shape of the injection hole 222 may be variously formed as necessary, but preferably, as shown in FIGS. 7 and 13A to 13C, a circular, elliptical, or inverse may be used to facilitate the flow of drugs. It may be formed in a triangular shape, the size of the hole 223 is preferably determined in a smaller range than the cutting portion 224 due to the nature of the mechanism to be inserted into the living body.
- a plurality of side holes 221 may be formed on the outer surface of the injection hole 222.
- a plurality of side holes 221 are formed on the whole or part of the outer surface of the injection hole 222, through the holes 223 and the plurality of side holes 221 of the injection hole in the wound site generated due to tissue collection Drugs can be accurately administered, there is an effect that can be easily administered to a large wound area.
- the side hole 221 may be formed at the tip of the injection hole 222 with a length of 10 to 20% based on the entire length of the injection hole 222 in the longitudinal direction.
- the cutting portion 224 for cutting the tissue is sharply formed at the tip of the tube 220, that is, the tube 220 position leading from the reservoir 234 of the needle assembly 230.
- the launch button 212 of the housing 210 may be installed as a two-stage button, and the user may launch the button 212. Press once to release the needle assembly 230 to the location of the tissue to be collected (see arrow C in FIG. 7), and once again to press the fire button 212, the tube 220 covers the needle assembly 230. Move to tip 232 of needle assembly 230 (see arrow D in FIG. 8).
- the tissue is cut and collected in the storage portion 234 by the cutting portion 224 provided at the tip portion of the tube 220.
- FIGS. 9 to 12 are views illustrating a sampling process of the apparatus 200 for collecting biological tissues according to the present invention.
- FIGS. 9 to 12 examples of the solid tissue will be described.
- a tube 220 and a needle assembly 230 coupled within the tube 220 are loaded into the housing 210 using a loading device (not shown) coupled to the housing 210, and then ultrasonic or computer monolayer.
- the tube 220 is inserted into the tumor tissue while viewing an imaging device (not shown) such as a photographing.
- the firing button 212 provided at the rear end of the housing 210 is pressed once, as shown in FIG. 10, the needle assembly 230 is fired and positioned on the tissue 240 to be collected.
- the tissue 240 to be collected may be solid or liquid. Therefore, in the case of liquid tissue, when the first slide 215 is slid toward the firing button 212, the liquid tissue flows into the first syringe 214 through the suction hole 236.
- the tissue 240 to be collected becomes solid.
- the cutting unit 224 cuts the tissue 240 positioned in the storage unit 234, and the cut tissue 240 is stored in the storage unit 234.
- the storage unit 234 of the cutting unit 224 is not particularly limited as long as the cut tissue 240 is a shape that can be stored well without leaking to the outside, but preferably shown in FIGS. 14A to 14D. It can be formed as.
- the second slide 217 Since the tissue is cut in the body, bleeding occurs around the tissue. Accordingly, when the second slide 217 is slid toward the tube 220, the second slide 217 is connected to the second slide 217.
- the drug 250 is administered to the bleeding portion through the injection hole 222, and as shown in FIG. 11, the drug 250 administered through the injection hole 222 is applied to the tissue collection portion and the bleeding portion.
- hemostatic agents tissue coalescing agents, tissue marking fluorescent and contrast materials, bone cement, tumor treatment drugs, and other tissue treatment materials may be used. .
- the collected tissue 240 is stored in the storage unit 234, and the stored tissue 240 is sent to a laboratory for examination. Perform.
- the needle assembly 230 is positioned on the tissue portion to be collected, and then the first slide 215 is slid toward the firing button 212. Liquid tissue flows into the first syringe 214 through 236.
- the first syringe 214 can be attached and detached, the first syringe 214 can be detached from the housing 210 and sent to the examination room to perform the inspection.
- Figure 16 is a plan view showing the operation of the needle assembly 330 according to FIG.
- the biological tissue collecting device 300 to which the needle assembly is applied according to another embodiment of the present invention is coupled to the front end of the housing 310 and the housing 310 as shown in FIGS. 3 and 7.
- a needle assembly 330 coupled to the tube 320 and collecting the biological tissue, and a cutting portion 338 for cutting the tissue is provided at the tip 332 of the needle assembly 330. It is characterized by being.
- the configuration and shape of the housing 310, tube 320 and needle assembly 330 are as described in the detailed description of FIGS. 3 and 7 and will be omitted.
- the cutting portion 338 for cutting tissue is sharply formed at the tip 332 of the needle assembly 330, ie, from the reservoir 334 to the tip 332.
- the launch button of the housing 310 is installed as a two-stage button. 330 is fired to the location of the tissue to be harvested (see arrow E in FIG. 15), and once again the firing button is pressed, the needle assembly 330 moves into the tube 320 (see arrow F in FIG. 16). .
- the tissue is cut and collected in the reservoir 334 by the cutting portion 338 provided at the tip portion 332 of the needle assembly 330.
- the biological tissue collecting device 200 As described above, the biological tissue collecting device 200 according to the embodiment of the present invention, the needle assembly 230 of the biological tissue collecting device, the storage unit 234 for storing the cut tissue, and collecting the liquid tissue
- the suction hole 236 is provided, the lower end of the tube 210 is provided with an injection hole 222 for injecting the drug into the wounded tissue, the injection hole 222 in the wounded portion of the human body due to tissue collection
- tissue collection and drug administration can be performed at the same time with one apparatus, thereby preventing bleeding and tumor cell contamination after tissue collection.
- the resection site can be marked, so that the biological tissue collection that can remove not only the tumor tissue during surgery, but also the areas where the drug may be contaminated with the tumor cells.
- a device can be provided.
- the tissue to be collected may be collected from the storage unit 234, and the liquid tissue may be easily collected into the suction hole 236.
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/648,685 US10695039B2 (en) | 2012-11-30 | 2013-11-29 | Biotissue sampling apparatus |
KR1020147010915A KR101463867B1 (ko) | 2012-11-30 | 2013-11-29 | 생체 조직 채취 장치 |
CN201380062814.1A CN104955403B (zh) | 2012-11-30 | 2013-11-29 | 活检取样装置 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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KR10-2012-0138295 | 2012-11-30 | ||
KR20120138295 | 2012-11-30 | ||
KR10-2013-0079977 | 2013-07-08 | ||
KR1020130079977A KR20140070333A (ko) | 2012-11-30 | 2013-07-08 | 생체 조직 채취 장치 |
Publications (1)
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WO2014084650A1 true WO2014084650A1 (fr) | 2014-06-05 |
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PCT/KR2013/010963 WO2014084650A1 (fr) | 2012-11-30 | 2013-11-29 | Appareil de prélèvement d'échantillon de tissu biologique |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN114533142A (zh) * | 2022-02-23 | 2022-05-27 | 上海交通大学医学院附属第九人民医院 | 一种组织良恶性快速检测活检穿刺枪 |
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US20050020938A1 (en) * | 2002-09-25 | 2005-01-27 | B-K Medical A/S | Catheter for insertion into the human body |
KR20110062386A (ko) * | 2009-12-03 | 2011-06-10 | 주식회사 엠아이텍 | 생검용 니들 장치 |
WO2011126898A2 (fr) * | 2010-03-30 | 2011-10-13 | Sparkmed Research, Llc | Sondes médicales, tubes et dispositifs libérant des médicaments |
KR20110118603A (ko) * | 2011-09-23 | 2011-10-31 | 박수희 | 세침을 이용한 생체조직검사용 적출기 |
WO2012060968A2 (fr) * | 2010-11-01 | 2012-05-10 | Devicor Medical Products, Inc. | Dispositif de biopsie à main équipé d'une aiguille à percussion |
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US20050020938A1 (en) * | 2002-09-25 | 2005-01-27 | B-K Medical A/S | Catheter for insertion into the human body |
KR20110062386A (ko) * | 2009-12-03 | 2011-06-10 | 주식회사 엠아이텍 | 생검용 니들 장치 |
WO2011126898A2 (fr) * | 2010-03-30 | 2011-10-13 | Sparkmed Research, Llc | Sondes médicales, tubes et dispositifs libérant des médicaments |
WO2012060968A2 (fr) * | 2010-11-01 | 2012-05-10 | Devicor Medical Products, Inc. | Dispositif de biopsie à main équipé d'une aiguille à percussion |
KR20110118603A (ko) * | 2011-09-23 | 2011-10-31 | 박수희 | 세침을 이용한 생체조직검사용 적출기 |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN114533142A (zh) * | 2022-02-23 | 2022-05-27 | 上海交通大学医学院附属第九人民医院 | 一种组织良恶性快速检测活检穿刺枪 |
CN114533142B (zh) * | 2022-02-23 | 2023-07-04 | 上海交通大学医学院附属第九人民医院 | 一种组织良恶性快速检测活检穿刺枪 |
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