WO2014054279A1

WO2014054279A1 - Syringe, drug solution injector, sealing member and method for producing sealing member

Info

Publication number: WO2014054279A1
Application number: PCT/JP2013/005857
Authority: WO
Inventors: 根本　茂; 宗仁栗本
Original assignee: 株式会社根本杏林堂
Priority date: 2012-10-04
Filing date: 2013-10-01
Publication date: 2014-04-10
Also published as: JP6104553B2; JP2014073246A

Abstract

The purpose of the present invention is to provide a syringe which is provided with a sealing member that exhibits good sliding performance, while being suppressed in separation of an ultra high molecular weight polyethylene film. A syringe (1) is provided with a cylinder (2) and a sealing member (4) that is in contact with the inner surface of the cylinder (2) and is slidable within the cylinder (2). This syringe (1) is characterized in that: the sealing member (4) comprises a base (40) and an ultra high molecular weight polyethylene film (6) that is bonded onto the base (40); the ultra high molecular weight polyethylene film (6) has an ultra high molecular weight polyethylene layer (61) and an adhesive film layer (62); and the ultra high molecular weight polyethylene film (6) is bonded to the base (40) by means of the adhesive film layer (62).

Description

Syringe, chemical injection device, sealing member, and manufacturing method of sealing member

The present invention relates to a syringe, particularly a syringe having an ultra high molecular weight polyethylene film bonded thereto, and a syringe for injecting a chemical solution, a seal member used for the syringe, and a method for manufacturing the seal member.

Conventionally, a medical instrument having a sliding member such as a gasket, the sliding member comprising a thermoplastic elastomer layer and a thermoplastic synthetic resin layer containing ultrahigh molecular weight polyethylene or the like coated on the outer surface side There has been known a medical device that is configured and has a thermoplastic synthetic resin layer containing a lubricating component (Patent Document 1).

JP-A-5-57018

However, such a conventional medical device has a problem that the resin layer containing ultrahigh molecular weight polyethylene or the like is easily peeled off from the base of the sliding member. On the other hand, a technique for improving the sliding performance by forming a coating film of silicone oil on the surface of a sealing member such as a gasket is also known. However, when silicone oil is used, it has been pointed out that silicone oil in contact with the chemical solution may elute into the chemical solution. Furthermore, it has been pointed out that the formed coating film may be peeled off and mixed into the chemical solution.

In order to solve the above problems, a syringe as an example of the present invention includes a cylinder for filling a chemical solution, and a seal member that contacts an inner surface of the cylinder and is slidable in the cylinder. Comprises a substrate and an ultrahigh molecular weight polyethylene film adhered on the substrate, the ultrahigh molecular weight polyethylene film having an ultrahigh molecular weight polyethylene layer and an adhesive film layer, and through the adhesive film layer It is bonded to the substrate.

A chemical injection device as another example of the present invention includes the syringe.

Further, another example of the sealing member of the present invention is a sealing member used in a syringe for injecting a chemical solution, and the sealing member includes a base and an ultrahigh molecular weight polyethylene film bonded onto the base. The ultra high molecular weight polyethylene film has an ultra high molecular weight polyethylene layer and an adhesive film layer, and is bonded to the substrate via the adhesive film layer.

Thus, it is possible to provide a seal member that can suppress peeling of the ultrahigh molecular weight polyethylene film and that exhibits good sliding performance, and a syringe or a chemical solution injection device that includes the seal member. Furthermore, since it is not necessary to use silicone oil, it is possible to prevent elution of silicone oil into the chemical solution and peeling of the coating film.

Further, another example of the manufacturing method of the sealing member of the present invention is a manufacturing method of a sealing member used for a syringe for injecting a chemical solution, and the concave member to which the constituent material of the base member of the sealing member is supplied. A first mold provided, and an outer peripheral runner groove having a shape surrounding the recess and a second mold provided with a runner for supplying the constituent material, and the outer peripheral runner groove The base material is formed by supplying the constituent material to the concave portion via the substrate.

Thereby, it is possible to produce a seal member that can suppress peeling of the ultra-high molecular weight polyethylene film and that exhibits good sliding performance.

Further features of the present invention will become apparent from the following description of embodiments, given by way of example with reference to the accompanying drawings.

It is a schematic sectional drawing of a syringe. It is the schematic sectional drawing and schematic external view of a sealing member. It is the schematic front view and schematic back view of a sealing member. It is a general | schematic expanded sectional view which shows the adhere | attached ultra high molecular weight polyethylene film. It is a graph which shows the sliding performance of a sealing member. It is a schematic sectional drawing explaining the formation process of a sealing member. It is a schematic sectional drawing explaining the formation process of a sealing member. It is a schematic sectional drawing explaining the formation process of a sealing member. It is a schematic sectional drawing explaining the trimming process of a sealing member. It is a schematic sectional drawing explaining the formation process of the sealing member as a comparative example. It is a schematic sectional drawing explaining the formation process of the sealing member which concerns on 2nd Embodiment. It is a schematic perspective view of the chemical injection device concerning a 3rd embodiment. It is a schematic perspective view of the prefilled syringe which concerns on 3rd Embodiment. It is a schematic perspective view of the prefilled syringe which concerns on 3rd Embodiment.

Hereinafter, exemplary embodiments for carrying out the present invention will be described in detail with reference to the drawings. However, unless otherwise specified, the dimensions, materials, shapes, and relative positions of the components described in the following examples are arbitrary, and the configuration of the apparatus to which the present invention is applied or various conditions. Can be changed according to Further, unless otherwise specified, the scope of the present invention is not limited to the examples specifically described below.

[First Embodiment]
A syringe 1 for injecting a chemical liquid shown in FIG. 1 is provided at a cylinder 2 for filling the chemical liquid to be injected, a plunger 3 slidable in the cylinder 2, and a tip of the plunger 3. And a seal member 4 that is in contact with the inner surface of the cylinder 2 and is slidable in the cylinder 2. The cylinder 2 has a hollow cylindrical portion, and a winged needle or the like is connected to the distal end portion 21 of the cylinder 2 via a tube (not shown). A slight gap is provided between the portion of the seal member 4 facing the top of the plunger 3 and the top of the plunger 3.

In this syringe 1, when filling the chemical solution, the plunger 3 is pulled out toward the rear end portion 22 of the cylinder 2, and the cylinder 2 is filled with the chemical solution through a tube or the like. In addition, when injecting the drug solution, the plunger 3 is pushed toward the tip portion 21 of the cylinder 2 to inject the drug solution into the patient's body through a tube or the like. The cylinder 2 and the plunger 3 can be formed from hard resin, soft resin, engineering plastic, glass, or the like.

The syringe 1 may be a prefilled syringe in which a chemical solution is filled in a cylinder in advance. In the case of a prefilled syringe, it is provided with a cylinder 2 filled with a chemical solution in advance, and a tip member 21 of the cylinder 2 is provided with a sealing member for sealing the cylinder 2 so that the chemical solution does not leak. The filled chemical solution is accommodated and held in the cylinder 2 by the sealing member and the seal member 4. In addition, as a chemical | medical solution with which the syringe 1 is filled also including the case of a prefilled syringe, a contrast agent, physiological saline, an anticancer agent, etc. are mentioned, for example.

Such a syringe 1 is used by being set in an injector which is an automatic injection device. The injector controls the operation of the syringe holding unit to which the syringe 1 filled with the chemical solution is mounted, the plunger 3 of the syringe 1 toward the cylinder 2, the memory, the CPU, and the like. And a control circuit provided. And an injector is hold | maintained on the stand with a caster etc., and can be used when inject | pouring a chemical | medical solution into a patient's body.

FIG. 2 shows a schematic sectional view showing a central section of the gasket as the sealing member 4 and a schematic external view when viewed from the side. In FIG. 2, a cross-sectional view is shown on the left side, and an external view is shown on the right side. FIG. 3 shows a schematic front view and a schematic back view of the seal member 4. Here, the front means the surface when the seal member 4 shown in FIG. 2 is viewed from above, and the back means the surface when the seal member 4 shown in FIG. 2 is viewed from below. . In FIG. 3, a front view is shown on the upper side, and a back view is shown on the lower side.

The sealing member 4 includes a base body 40 and an ultrahigh molecular weight polyethylene film 6 bonded on the base body 40. Further, the seal member 4 has a height of, for example, 9 to 20 mm from the apex of the front end portion 43 to the rear end portion. The ultrahigh molecular weight polyethylene film 6 has a thickness of 10 to 100 μm, for example. The distal end portion 43 of the seal member 4 has a substantially conical shape and is a portion that comes into contact with the chemical solution filled in the cylinder 2.

Further, two annular protrusions 41 that are in contact with the inner surface of the cylinder 2 and an annular recess 45 provided between the annular protrusions 41 are formed on the side surface of the seal member 4. The ultrahigh molecular weight polyethylene film 6 is adhered by an adhesive film layer 62 described later so as to be in close contact with the tip portion 43, the annular protrusion 41, and the annular recess 45 of the seal member 4. Further, a recess 46 into which the tip of the plunger 3 is inserted is formed inside the seal member 4. An engagement groove 42 is formed in the recess 46, and the engagement groove 42 can be engaged with a protrusion formed at the tip of the plunger 3 by inserting the tip of the plunger 3. In addition, a screw type mooring system is used in which a screw groove is provided so that the tip of the plunger 3 is formed in a male screw shape, and a screw groove is provided so that the inner surface of the concave portion 46 of the seal member 4 is formed in a female screw shape. You can also.

As shown in FIG. 3, the seal member 4 has a substantially circular outer shape so as to contact the inner surface of the cylindrical portion of the cylinder 2. An opening 47 that communicates with the recess 46 is formed on the rear end side of the seal member 4. The tip of the plunger 3 is inserted into the recess 46 through the opening 47. The substrate 40 can be formed from styrene elastomer, halogenated butyl rubber, styrene butadiene rubber, silicone rubber, or the like.

Next, the bonded ultra-high molecular weight polyethylene film 6 will be described with reference to FIG. The ultra high molecular weight polyethylene film 6 has an ultra high molecular weight polyethylene layer 61 and an adhesive film layer 62. The ultrahigh molecular weight polyethylene film 6 is bonded to the substrate 40 through the adhesive film layer 62. The adhesive film layer 62 is made of a thermoplastic resin having a melting point lower than that of the ultrahigh molecular weight polyethylene layer 61. The adhesive film layer 62 has a thickness of 10 to 100 μm, for example.

Examples of such adhesive film layer 62 include polyethylene film, polyvinyl alcohol film, ethylene-vinyl acetate copolymer film, ethylene-vinyl alcohol copolymer film, ethylene-methacrylic acid copolymer film, linear low density ( Rhodenity) polyethylene film and the like. Among these, a linear low density polyethylene film or an ethylene-vinyl acetate copolymer film is excellent in adhesiveness. Therefore, the adhesive film layer 62 is preferably made of a linear low density polyethylene film or an ethylene-vinyl acetate copolymer film. In particular, since the linear low density polyethylene film is excellent in adhesiveness, the adhesive film layer 62 is more preferably composed of a linear low density polyethylene film. Since no harmful additive is used in this linear low density polyethylene film, it is also suitable as a film used in the syringe 1 for injecting a chemical solution.

Further, the film for the adhesive film layer 62 includes low density polyethylene, medium density polyethylene, ionomer, ethylene-acrylic acid ester copolymer, ethylene-methacrylic acid ester copolymer, ethylene-propylene copolymer, poly (ethylene butylene). ) Selected from a resin mixture comprising a polystyrene block copolymer and polypropylene, a hydrogenated styrene butadiene rubber and a resin mixture comprising polyethylene, a hydrogenated styrene butadiene rubber and a resin mixture comprising polypropylene, etc. It can be comprised from the resin made.

FIG. 5 shows a graph comparing the sliding resistance of the sealing member 4 with that of the comparative sealing member. In FIG. 5, the vertical axis indicates the plunger pressing force (N), and the horizontal axis indicates the time (sec). Further, in the sealing member of the comparative example, silicone oil is applied to the surface of the base made of silicone rubber. The comparison was performed by connecting a 21G winged needle to a 50 ml size syringe filled with water and pushing the plunger into the cylinder with the syringe fixed. The plunger was pushed horizontally with respect to the mounting surface of the syringe, and the plunger pushing force at the time of pushing was measured. Note that a push-pull gauge (tester) was used to measure the plunger pressing force, and the value at the time when the pressing force value did not change during pressing was measured. Moreover, the syringe which uses a polypropylene resin is used for the syringe.

As shown in FIG. 5, the plunger pressing force of the seal member 4 according to the present embodiment has only a difference of about 20 N from the plunger pressing force of the seal member in the comparative example. It can be said that it has good sliding performance. That is, the same good sliding performance can be exhibited without using silicone oil. By using this sealing member 4, it is possible to prevent the elution of silicone oil into the chemical solution and the peeling of the coating film. Furthermore, according to the seal member 4 according to the present embodiment, good sliding performance can be exhibited, so that stable chemical injection can be performed. Moreover, according to such a sealing member 4, a chemical | medical solution can also be inject | poured by pushing the plunger 3 manually.

Subsequently, a method for manufacturing the syringe member 4 used in the syringe 1 for injecting a chemical solution will be described with reference to FIGS. FIG. 6 is a schematic cross-sectional view showing the molding die in a state before molding of the seal member 4, showing the lower die 8 (first die) on the lower side and the upper die 7 ( 2nd mold). FIG. 7 is a schematic cross-sectional view showing a state before the constituent material of the base body 40 is injected in the molding process of the seal member 4. FIG. 8 is a schematic cross section showing a state in which the constituent material of the base body 40 is injected in the molding process of the seal member 4. FIG. 9 is a schematic cross-sectional view for explaining a trimming process for trimming the seal member 4 after the base body 40 is formed. In FIG. 9, the lower mold 8 and the upper mold 7 are not shown for convenience of explanation.

As shown in FIG. 6, the lower mold 8 includes a recess 81 into which the protruding portion 72 of the upper mold 7 is inserted during molding, and an air vent 85 as an air vent hole. The recess 81 has an inner surface shape corresponding to the outer surface shape of the seal member 4, that is, an inner surface shape that substantially matches the outer surface shape of the seal member 4. Then, the protruding portion 72 is inserted into the recess 81 through the opening 82 of the recess 81. As will be described later, the constituent material of the base body 40 of the seal member 4 is supplied to the recess 81. The upper mold 7 or the lower mold 8 can be moved relative to the other in the vertical direction by a moving mechanism (not shown).

The upper mold 7 includes a runner 71 for supplying the constituent material of the base body 40. In addition, in this embodiment, although the runner 71 of the upper mold | die 7 is two, one or three or more runners may be sufficient. The upper mold 7 is positioned between the protruding portion 72 having an outer surface shape corresponding to the inner surface shape of the concave portion 46 of the seal member 4, the runner 71 and the protruding portion 72, and the concave portion 81 of the lower mold 8. The outer peripheral runner groove 73 having a shape surrounding the gate, the gate 74 that narrows the flow path of the constituent material of the base 40 when the mold is closed, and the air vent 75 as an air vent hole are provided. The shape of the outer peripheral runner groove 73 can be selected from various shapes such as a circular shape, an elliptical shape, and a polygonal shape.

And the outer periphery runner groove | channel 73 of this embodiment has a shape surrounding the opening 82 of the recessed part 81 of the lower metal mold | die 8. FIG. Furthermore, in the case of this embodiment, the outer periphery runner groove 73 is larger than the outer shape of the seal member 4, and preferably has a circular shape. That is, the outer peripheral runner groove 73 is configured to be located slightly outside the opening 82. Therefore, as shown by the arrow A in FIG. 6, the outer peripheral runner groove 73 has a diameter (inner diameter) larger than the diameter of the opening 82. Thereby, the outer periphery runner groove | channel 73 has an internal diameter larger than the outer dimension of the sealing member 4 shape | molded. In FIG. 6, the width of the gate 74 substantially corresponds to the difference between the inner diameter of the outer peripheral runner groove 73 and the diameter of the opening 82.

When the seal member 4 is molded, first, the lower mold 8 provided with the concave portion 81 and the upper mold 7 provided with the outer peripheral runner groove 73 and the runner 71 are arranged to face each other. Then, the ultrahigh molecular weight polyethylene film 6 is placed on the lower mold 8 so that the adhesive film layer 62 faces the runner 71 side. Next, as shown in FIG. 7, the protruding portion 72 of the upper mold 7 is brought into contact with the ultrahigh molecular weight polyethylene film 6, and the ultrahigh molecular weight polyethylene film 6 is pushed into the recess 81 of the lower mold 8. At the same time, as shown in FIG. 8, the constituent material of the base body 40 is injected from the runner 71 of the upper mold 7. At this time, as shown by an arrow in FIG. 8, the constituent material of the base body 40 is supplied to the recess 81 through the outer peripheral runner groove 73. Therefore, the constituent material of the base body 40 is guided to the outer peripheral runner groove 73 and flows into the recess 81 from the entire periphery of the protruding portion 72. That is, the constituent material of the base body 40 flows around the inner side of the outer peripheral runner groove 73 and flows into the recess 81.

Then, the ultrahigh molecular weight polyethylene film 6 is pushed into the recess 81 from the entire periphery of the protruding portion 72 by the constituent material of the base body 40. Therefore, the ultrahigh molecular weight polyethylene film 6 can be accurately pushed into the recess 81 without performing pre-shaping with the upper mold 7. Thereby, the preliminary shaping process of the ultra high molecular weight polyethylene film 6 can be omitted. Then, after the molding of the seal member 4 is completed, trimming is performed at a position indicated by a dotted line in FIG. 9 to cut off an excess portion protruding from the main body of the seal member 4. Specifically, a concave portion is formed at a position corresponding to the gate 74 in the protruding portion, and a convex portion is formed at a position corresponding to the runner 71. Therefore, such a recessed part and a convex part are excised by trimming. Thus, the seal member 4 is manufactured. The trimming is performed at a position along the outer shape of the seal member 4.

The seal member 4 manufactured in this way is combined with the plunger 3 and the cylinder 2 manufactured separately. That is, the tip of the plunger 3 is inserted into the recess 46 of the seal member 4, and the protrusion formed at the tip of the plunger 3 is engaged with the engagement groove 42 in the recess 46. Then, the plunger 3 to which the seal member 4 is attached is inserted into the cylinder 2. In this way, the syringe 1 is manufactured. Furthermore, in the case of a prefilled syringe, the cylinder 2 is filled with a chemical solution, and a sealing member is attached to the tip portion 21 of the cylinder 2.

According to the manufacturing method of the seal member 4 according to the present embodiment, it is possible to prevent the gate mark from being formed on the base body 40 of the seal member 4. Here, the gate mark is a protrusion or a recess formed in a portion of the base corresponding to the gate of the mold when the base of the seal member is formed. In this regard, in the conventional molding method, as shown in FIG. 10, the runner 171 and the gate 174 of the upper mold 170 for injecting the constituent material of the base 140 are located inside the tip portion of the base 140 of the seal member 104. It is arranged at the corresponding position. Therefore, a gate mark 172 is formed at a position corresponding to the runner 171 inside the tip portion of the base body 140. On the other hand, a gate mark 173 is formed at a position corresponding to the runner 171 (a position corresponding to the air vent 175) outside the tip portion of the base 140.

When the gate mark 173 is formed, the film 106 is easily peeled off from a portion between the gate mark 173 and the film 106 covering the base 140. Further, the gate mark 173 of the base 140 is also reflected on the outer side of the tip portion of the seal member 104. And since the front-end | tip part outer side of the sealing member 104 contacts with a chemical | medical solution, there exists a possibility that a bubble may arise in a chemical | medical solution. That is, air bubbles are likely to be generated in the chemical liquid due to the collection of micro bubbles in the concave portion outside the tip portion. Further, the sealing member 104 having such a recess has a problem that it looks bad.

On the other hand, the outer surface of the distal end portion of the seal member 4 manufactured by the manufacturing method according to the present embodiment is a smooth surface without irregularities as shown in FIG. This is because the position where the runner 71 of the upper mold 7 is provided corresponds to a portion cut out from the main body of the seal member 4 by trimming. Therefore, even if a gate mark is formed at a position corresponding to the runner 71, the gate mark is not left in the main body of the seal member 4 because it is removed by trimming. In this regard, in the conventional manufacturing method, if the runner is provided at such a position, the constituent material of the base body cannot be sufficiently allowed to flow into the recess of the lower mold. That is, since the flow of the constituent material of the base that flows into the recess from the runner is biased, the position where the runner is provided is limited.

In contrast, in the manufacturing method according to the present embodiment, the outer mold runner groove 73 having a size corresponding to the outer shape of the seal member 4 is provided in the upper mold 7. Therefore, the constituent material of the base body 40 flows into the recess 81 from the entire periphery of the recess 81 of the lower mold 8 by the outer peripheral runner groove 73. Thereby, the flow of the constituent material of the base body flowing from the runner 71 into the concave portion 81 can be prevented from being biased, and the constituent material of the base body 40 can flow into the entire concave portion 81 of the lower mold 8. Therefore, according to the manufacturing method according to the present embodiment, the runner 71 of the upper mold 7 can be provided at a position corresponding to a portion cut from the main body of the seal member 4 by trimming. As a result, gate traces are prevented from being formed on the base body 40 of the seal member 4, and the outer surface of the tip end portion of the seal member 4 becomes a smooth surface with no irregularities. And since the front-end | tip part has a smooth surface, the appearance of the sealing member 4 can also be improved.

According to the seal member 4 according to the first embodiment described above and the syringe 1 provided with the seal member 4, peeling of the ultrahigh molecular weight polyethylene film 6 can be suppressed. At the same time, it is possible to provide the seal member 4 exhibiting good sliding performance or the syringe 1 provided with the seal member 4. Furthermore, since it is not necessary to use silicone oil, it is possible to prevent elution of silicone oil into the chemical solution and peeling of the coating film.

Furthermore, by forming the ultrahigh molecular weight polyethylene layer 61 of the ultrahigh molecular weight polyethylene film 6 from only the ultrahigh molecular weight polyethylene, even the ultrahigh molecular weight polyethylene film 6 not containing silicon can be satisfactorily adhered. If such an ultra high molecular weight polyethylene film 6 is used, elution of silicone oil into the chemical solution and peeling of the coating film can be more reliably prevented.

Moreover, according to the manufacturing method of the sealing member 4 according to the first embodiment, it is possible to manufacture a sealing member that can suppress peeling of the ultrahigh molecular weight polyethylene film and that exhibits good sliding performance. Furthermore, gate traces can be prevented from being formed on the outer surface of the tip portion of the seal member 4. Thereby, the front-end | tip part outer surface of the sealing member 4 can be made into the smooth surface without an unevenness | corrugation. Furthermore, since the preliminary shaping step can be omitted, the manufacturing cost can be reduced and the manufacturing time can be shortened.

The position where the outer peripheral runner groove 73 of the upper mold 7 is provided may be a position facing the opening 82 of the lower mold 8. Further, the position where the outer peripheral runner groove 73 is provided may be slightly inside the opening 82. Even when the outer peripheral runner groove 73 is provided at such a position, the constituent material of the base body 40 can be poured into the entire recess 81 of the lower mold 8.

[Second Embodiment]
Then, with reference to FIG. 11, the manufacturing method of the sealing member 4 which concerns on 2nd Embodiment is demonstrated. In the description of the second embodiment, differences from the first embodiment will be described, and the components described in the first embodiment will be denoted by the same reference numerals and description thereof will be omitted. Except for the case where it is specifically described, the components given the same reference numerals perform substantially the same operations and functions, and the effects thereof are also substantially the same.

FIG. 11 is a schematic cross-sectional view showing a state in which the constituent material of the substrate is injected in the molding process of the seal member, showing the upper mold 27 on the upper side and the lower mold 28 on the lower side. In the first embodiment, the runner 71 of the upper mold 7 is open outside the outer peripheral runner groove 73. On the other hand, in the second embodiment, the runner 271 of the upper mold 27 opens in the outer peripheral runner groove 273.

As in the first embodiment, the upper mold 27 is arranged to face the lower mold 28. The lower mold 28 includes a recess 281 into which the protruding portion 272 of the upper mold 27 is inserted during molding, and an air vent 285 as an air vent hole. The recess 281 has an inner surface shape corresponding to the outer surface shape of the seal member 4, and the protruding portion 272 is inserted into the recess 281 through the opening 282 of the recess 281. On the other hand, the upper mold 27 includes a runner 271 for injecting the constituent material of the base body 40, a projecting portion 272 having an outer surface shape corresponding to the inner surface shape of the concave portion 46 of the seal member 4, and when the mold is closed. A gate 274 for narrowing the flow path of the constituent material of the base 40 and an air vent 275 as an air vent hole are provided. In addition, the shape of the outer periphery runner groove | channel 273 can be selected from various shapes similarly to 1st Embodiment. In the second embodiment, the runner 271 of the upper mold 27 is opened in the outer peripheral runner groove 273.

Also in the second embodiment, the process of forming the seal member 4 is substantially the same as in the first embodiment. That is, first, the ultrahigh molecular weight polyethylene film 6 is placed on the lower mold 28. Next, the protruding portion 272 of the upper mold 27 is brought into contact with the ultrahigh molecular weight polyethylene film 6, and the ultrahigh molecular weight polyethylene film 6 is pushed into the recess 281 of the lower mold 28. Thereafter, the constituent material of the base body 40 is supplied from the runner 271 of the upper mold 27. At this time, the constituent material of the base body 40 is guided to the outer peripheral runner groove 273 and flows into the recess 281 from the entire periphery of the protruding portion 272. Therefore, the ultrahigh molecular weight polyethylene film 6 is pushed into the recess 281 from the entire periphery of the protruding portion 272 by the constituent material of the injected base body 40. After the molding, a trimming process is performed, and an excess portion protruding from the main body of the seal member 4 is cut off, whereby the seal member 4 is manufactured.

Also by the manufacturing method of the sealing member 4 of the second embodiment, it is possible to manufacture a sealing member that can suppress the peeling of the ultrahigh molecular weight polyethylene film and that exhibits good sliding performance. Furthermore, gate traces can be prevented from being formed on the outer surface of the tip portion of the seal member 4. Thereby, the front-end | tip part outer surface of the sealing member 4 can be made into the smooth surface without an unevenness | corrugation. Furthermore, since the preliminary shaping step can be omitted, the manufacturing cost can be reduced and the manufacturing time can be shortened.

[Third Embodiment]
FIG. 12 is a schematic perspective view of a chemical liquid injector (injector) 320 according to the third embodiment. Moreover, FIG.13 and FIG.14 shows the prefilled syringe with which the chemical | medical solution injection apparatus 320 which concerns on 3rd Embodiment is mounted | worn.

A chemical solution injection device 320 for injecting a chemical solution such as a contrast medium into a patient is provided with a first syringe 301 and a second syringe 302, an adapter 311 for attaching the first syringe 301, and a second syringe 302. Adapter 312. And the 1st syringe 301 and the 2nd syringe 302 are provided with the sealing member 4 (not shown) mentioned above. A tube 303 is connected to the first syringe 301 and the second syringe 302. Further, the head of the chemical solution injector 320 is rotatably held on an upper portion of a stand pole 317 on a movable stand base 316 placed on the floor surface. Accordingly, the head end side (the side on which the first syringe 301 and the second syringe 302 are mounted) is directed toward the floor, and the rear end side of the head (the side on which the first syringe 301 and the second syringe 302 are not mounted). ) Can be turned to a posture in which the head is directed toward the floor.

The chemical solution injector 320 is wired or wirelessly connected to an imaging device (not shown), and various data are transmitted and received between the imaging device and the chemical injector 320 when the chemical solution is injected and when an image is taken. Examples of such an imaging apparatus include an MRI (Magnetic Resonance Imaging) apparatus, a CT (Computed Tomography) apparatus, an angio imaging apparatus, a PET (Positron Emission Tomography) apparatus, a SPECT (Single Photon Emission Computed Tomography) apparatus, and a CT angio apparatus. There are various medical imaging devices such as MR angio devices, ultrasonic diagnostic devices, and blood vessel imaging devices.

Moreover, the chemical liquid injector 320 further includes a control device such as a console (not shown). The head of the chemical liquid injector 320 and the control device are wired or wirelessly connected. This control device includes a touch panel and is connected to a hand switch by wire or wirelessly and functions as a controller. Further, the control device prestores operation pattern (injection protocol) data, drug solution data, and the like. When injecting a drug solution into a patient, the operator operates the touch panel to input patient physical data such as an injection rate, an injection amount, an injection time, and a body weight, and data on the type of the drug solution. Then, the control device calculates optimal injection conditions according to the input data and data stored in advance. Thereafter, the control device determines the amount of the medical solution to be injected into the patient and the injection protocol based on the calculated injection conditions.

When the control device determines the amount of the chemical and the injection protocol, the control device displays predetermined data or a graph on the touch panel. Then, the operator checks the displayed data or graph and presses the start button on the head if the injection operation is actually started. When the start button is pressed, the injection of the chemical is started. Alternatively, injection can be initiated by pressing a button on the hand switch. Note that the operation pattern (injection protocol) data, drug solution data, and the like can be input from an external storage medium.

In the third embodiment, the first syringe 301 and the second syringe 302 are both prefilled syringes. The cylinders 2 of the first syringe 301 and the second syringe 302 are filled with a chemical solution in advance. The prefilled syringe will be described with reference to FIGS. 13 and 14 by taking the first syringe 301 as an example.

The first syringe 301 shown in FIG. 13 is a 200 ml sized prefilled syringe, a schematic perspective view of the entire syringe is shown in the upper left of FIG. 13, and a schematic perspective view of the cylinder 2 viewed from the rear end side is shown in the lower right of FIG. ing. The first syringe 301 includes a cylinder 2 filled with a chemical solution, a plunger 3 slidable in the cylinder 2, and the above-described seal member 4 (not shown) attached to the tip of the plunger 3. Prepare. The plunger 3 is attached by screwing into the seal member 4. A sealing member (not shown) such as a cap is provided at the tip of the cylinder 2, and the sealing member is removed before the first syringe 301 is attached, and the tube 303 is connected to the tip of the first syringe 301. Is done.

Also, a flange is formed at the rear end of the cylinder 2. The flange includes a notch 313 for fitting into the adapter 311 (FIG. 12) of the chemical liquid injector 320, a ring-shaped rib 314, and a rib 315 that rises in the rear end direction of the cylinder 2. When mounting the first syringe 301, the flange of the first syringe 301 can be inserted into the adapter 311 of the chemical liquid injector 320 and rotated to fit the flange into the adapter 311 and be fixed. In FIG. 13, five ribs 315 are formed, but four or fewer ribs 315 or six or more ribs 315 may be formed.

On the other hand, the 1st syringe 301 shown in FIG. 14 is a 100 ml size prefilled syringe, the schematic perspective view of the whole syringe is shown on the upper left, and the schematic perspective view which looked at the cylinder 2 from the rear end side is shown on the lower right. . The first syringe 301 also includes a cylinder 2 filled with a chemical, a plunger 3 slidable in the cylinder 2, and the above-described seal member 4 (not shown) attached to the tip of the plunger 3. Prepare. Also in FIG. 14, a flange is formed at the rear end of the cylinder 2, and the flange includes a notch 313 for fitting into the adapter 311 (FIG. 12) of the chemical liquid injector 320 and a ring-shaped rib 314. Have. The first syringe 301 shown in FIG. 14 is different from FIG. 13 in that it does not have a rib 315 that rises in the rear end direction. However, in FIG. 14, plate-like ribs 315 can be formed.

According to the chemical solution injection system 300 according to the third embodiment as described above, since the above-described seal member 4 is provided, good sliding performance can be exhibited, so that stable chemical solution injection is possible. In addition, as the 1st syringe 301 or the 2nd syringe 302, syringes of various sizes, such as 200 ml, 100 ml, and 50 ml, can be used. Further, the first syringe 301 or the second syringe 302 may be a suction type syringe that sucks a chemical solution from a chemical solution bag or the like.

The present invention has been described above with reference to the embodiments, but the present invention is not limited to the above embodiments. Inventions modified within the scope not departing from the present invention and inventions equivalent to the present invention are also included in the present invention. Moreover, each above-mentioned embodiment and modification can be combined suitably in the range which is not contrary to this invention.

In addition, the method of adhering the ultra high molecular weight polyethylene film 6 is not limited to the method described in the above embodiment. For example, the ultrahigh molecular weight polyethylene film 6 can be bonded using a three-dimensional film forming method. Specifically, adhesion of the ultrahigh molecular weight polyethylene film 6 using a three-dimensional film forming method is performed as follows. First, the base body 40 is set in the lower housing. And the ultra high molecular weight polyethylene film 6 is set between the upper housing and the lower housing facing the lower housing. Thereafter, the upper casing is lowered toward the lower casing, and the space between the upper casing and the lower casing is vacuum-sucked. And the ultra high molecular weight polyethylene film 6 is heated with the heater provided in the upper side housing. Next, the ultrahigh molecular weight polyethylene film 6 is adhered to the substrate 40 by atmospheric pressure or compressed air pressure.

In the bonding by this three-dimensional film forming method, it may be difficult to bond the ultrahigh molecular weight polyethylene film 6 to the side surface of the seal member 4, particularly to the portion corresponding to the annular recess 45. In such a case, the ultrahigh molecular weight polyethylene film 6 can be adhered by blowing compressed air to the portion corresponding to the annular recess 45. This blowing of compressed air can be performed by blowing compressed air through an air hole having an annular shape corresponding to the annular recess 45. Alternatively, the ultrahigh molecular weight polyethylene film 6 can be adhered to the entire annular recess 45 by blowing compressed air through an air hole provided at a position facing the annular recess 45 and rotating the substrate 40.

Moreover, the ultrahigh molecular weight polyethylene film 6 is not limited to a two-layer structure, and may have a layer structure of three or more layers. For example, an ultrahigh molecular weight polyethylene film 6 having a three-layer structure including two adhesive film layers 62 and an ultrahigh molecular weight polyethylene layer 61 may be used. As the ultrahigh molecular weight polyethylene layer 61, various films containing ultrahigh molecular weight polyethylene can be used, but it is desirable to use a film composed only of ultrahigh molecular weight polyethylene.

Furthermore, in the above embodiment, the ultrahigh molecular weight polyethylene film 6 was provided on the entire outer surface of the seal member 4. However, the ultrahigh molecular weight polyethylene film 6 can be provided only in a partial region of the outer surface of the seal member 4, for example, only in a portion that contacts the chemical solution or only in a portion that contacts the inner surface of the cylinder 2. Further, the ultrahigh molecular weight polyethylene film 6 can be adhered to the inner surface of the cylinder 2 similarly to the seal member 4.

This application claims priority from Japanese Patent Application No. 2012-222349 filed on October 4, 2012, the contents of which are incorporated herein by reference.

1: Syringe, 2: Cylinder, 3: Plunger, 4: Sealing member, 6: Ultra high molecular weight polyethylene film, 7: Upper mold, 8: Lower mold, 21: Front end, 22: Rear end, 27 : Upper mold, 28: lower mold, 40: base, 41: annular protrusion, 42: engagement groove, 43: tip, 45: annular recess, 46: recess, 47: opening, 61: ultra high molecular weight Polyethylene layer, 62: adhesive film layer, 71: runner, 72: protruding portion, 73: outer peripheral runner groove, 74: gate, 75: air vent, 81: recess, 82: opening, 85: air vent, 104: seal member, 106 : Film, 140: Substrate, 170: Upper mold, 171: Runner, 172: Gate mark, 173: Gate mark, 174: Gate, 175: Air vent, 271: Runner, 272: Protruding part, 273: Outer circumference Ner groove, 274: gate, 275: air vent, 281: recess, 282: opening, 285: air vent, 301: first syringe, 302: second syringe, 303: tube, 311: adapter, 312: adapter, 313: cut Notch, 314: rib, 315: rib, 316: stand base, 317: stand pole, 320: chemical injection device

Claims

A cylinder,
A seal member that contacts the inner surface of the cylinder and is slidable in the cylinder;
The seal member has a base and an ultra-high molecular weight polyethylene film adhered on the base,
The ultra high molecular weight polyethylene film has an ultra high molecular weight polyethylene layer and an adhesive film layer, and is bonded to the substrate through the adhesive film layer.
The syringe according to claim 1, wherein the adhesive film layer is made of a linear low density polyethylene film or an ethylene-vinyl acetate copolymer film.
The syringe according to claim 1 or 2, wherein the syringe is a prefilled syringe in which the cylinder is filled with a chemical solution.
A chemical injection device comprising the syringe according to any one of claims 1 to 3.
A seal member used in a syringe for injecting a chemical solution,
The sealing member has a base and an ultra-high molecular weight polyethylene film adhered on the base,
The ultra high molecular weight polyethylene film has an ultra high molecular weight polyethylene layer and an adhesive film layer, and is bonded to the substrate via the adhesive film layer.
A method for producing a seal member used in a syringe for injecting a chemical solution,
A first mold having a recess to which the constituent material of the base member of the seal member is supplied; a second outer runner groove having a shape surrounding the recess; and a second runner for supplying the constituent material. Are placed opposite to each other,
A method for producing a seal member, comprising: forming the base by supplying the constituent material to the recess through the outer peripheral runner groove.
The manufacturing method of a seal member according to claim 6, wherein the outer peripheral runner groove has a shape surrounding the opening of the recess.
The manufacturing method of a seal member according to claim 7, wherein the outer peripheral runner groove has a diameter larger than the diameter of the opening.
The said runner opens in the said outer periphery runner groove | channel, The manufacturing method of the sealing member of any one of Claim 6 thru | or 8 characterized by the above-mentioned.