JP4432734B2 - Medical device and manufacturing method thereof - Google Patents

Description

  The present invention relates to a medical device used for infusion, blood transfusion, dialysis circuit, and the like, and more specifically, a tubular member made of different materials, for example, a medical device in which a soft member and a hard member are joined so as not to easily separate. The present invention relates to a tool and a method for manufacturing the same.

  Conventionally, as a medical device in which members made of different materials are joined, an infusion device in which a polypropylene drip tube and a soft polyvinyl chloride tube are connected, a polypropylene infusion bag and a soft polyvinyl chloride tube are provided. There are connected infusion devices and the like. Solvent adhesives such as tetrahydrofuran, methyl ethyl ketone, cyclohexanone, and cyclohexane are effective for bonding similar materials such as soft polyvinyl chloride tubes and soft polyvinyl chloride connectors, but soft polyvinyl chloride tubes and polypropylene There is no effect on the adhesion of the drip tube, etc., and the soft polyvinyl chloride tube connected to the polypropylene material is creeped and stress relaxed during long-term storage, and the soft polyvinyl chloride tube was actively pulled In such a case, there was a risk that the tube would fall off from the connecting portion.

  In order to solve such problems, bonding is performed using a UV curable adhesive or a low-melting-point material member. Furthermore, a material that can be solvent-bonded to a soft polyvinyl chloride tube has been used as a connecting material. In the former method, the first tubular member made by joining the tubular member made of a soft material that can be bonded with the UV curable adhesive and the tubular member of the medical device, and the second tubular member made of a material difficult to bond with the UV curable adhesive. In a medical device having the above, there is a known method for preventing the detachment by filling a bonding space with ribs with a UV curable adhesive and curing it (Patent Document 1). However, when UV curable adhesives are used, there are problems such as a decrease in connection strength due to sterilization, the burden of applying adhesives, and the material of the adherend being limited. Especially, the adherend is a soft material such as a polybutadiene tube. In the case of the material, there is a drawback that there is almost no adhesion to the UV curable adhesive.

  In the latter method, which replaces these methods, a third member containing a synthetic resin material is inserted between the first member and the second member, and only the third member is melted and then solidified. Joining (caulking) the second member is also performed (Patent Document 2). In this method, the third member has a lower melting point than the lower one of the melting points of the first and second members, and exceeds the melting point of the third member, but of the melting points of the first and second members. Heat (join) by heating at a temperature lower than the lower temperature. Therefore, when the second tubular member is a polybutadiene tube having a melting point of 70 to 80 ° C., it is difficult to select a material for the third member having a lower melting point than that of the polybutadiene tube and excellent in medical safety, and There is a drawback that the shape and insertion positioning are difficult.

  Furthermore, as a method of using a material that can be bonded to a soft polyvinyl chloride tube and a solvent as a connecting material, a soft polyvinyl chloride tube and a polyvinyl chloride (PVC) excellent in solvent adhesive property are installed under the polypropylene drip tube. There is a method in which a connector made of an acrylonitrile-butadiene-styrene copolymer (ABS resin) is ultrasonically welded to the lower part of the drip tube, a soft polyvinyl chloride tube is inserted into the connector, and a solvent is bonded. Known (Patent Document 3). However, this connector material has good adhesiveness to a soft polyvinyl chloride tube, but has a disadvantage that it is inferior to the later-described polybutadiene tube and solvent adhesiveness.

Japanese Patent Publication No.2-18103 Japanese Patent Laid-Open No. 2-80059 JP-A 63-283651

  In recent years, when a polyvinyl chloride molded product is used and then discarded, incineration causes a problem of generating harmful gases such as dioxins, and various plastic molded products are used instead of polyvinyl chloride. Among these plastics, polybutadiene or styrene-based elastomers are attracting attention as non-adsorbing soft materials because they are excellent in flexibility and transparency as soft materials and do not adsorb drugs such as glycerin and insulin. Among them, polybutadiene is particularly used as a medical device for non-polyvinyl chloride tubular members from the viewpoint of price, medical safety, functionality and the like. A typical example is a polypropylene drip tube (drip tube) which is a rigid tubular member of a first member and a soft polybutadiene tubular member (polybutadiene tube) which is a second member fitted (joined) to the drip tube.

  Such a drip tube and a polybutadiene tube can be joined by, for example, a large-diameter tubular projecting portion (with a rib having a height of 0.3 mm or less on the inner surface of the projecting portion) provided on the bottom of the drip tube and a tapered small diameter. An annular gap is formed between the tubular projection and the polybutadiene tube is inserted into the outer end of the gap, and the rib on the inner surface of the large-diameter tubular projection is designed to contact the outer surface of the polybutadiene tube insertion tip. ing. The small diameter tubular protrusion tip diameter is smaller than the polybutadiene tube inner diameter, and the small diameter tubular end diameter is larger than the polybutadiene tube inner diameter. However, due to heat treatment at 60 ° C for 24 hours or longer including ethylene oxide gas sterilization treatment, ethylene oxide gas degassing treatment, etc., the polybutadiene tube loosens due to relaxation of residual stress, and the rebound resilience (creep) decreases due to long-term storage. Tube loosening occurs.

  Therefore, a method is generally used in which a UV curable adhesive is poured (applied) into the annular gap between the large-diameter tubular protrusion and the polybutadiene tube to close the annular gap. However, commercially available UV curable adhesives have weak adhesive strength between both the polypropylene and polybutadiene tubes, which are the materials of the drip tube, and if the adhesive is insufficiently applied, the drip tube may become abnormal due to an abnormal phenomenon such as clogging of the polybutadiene tube. If pressure is applied inside, there is a risk of infusion in the drip tube leaking. Moreover, it is difficult to manage the UV curable adhesive, and further, there is a drawback that means of UV irradiation is required.

  In addition, polypropylene, polycarbonate, polyethylene, acrylonitrile-butadiene-styrene copolymer, etc., which are harder than polybutadiene tubes, are often used as medical device materials such as connectors for connecting polybutadiene tubes and rigid annular members such as ports. However, no measures have been found at present for completely joining the polybutadiene tube, which is a difficult-to-adhere material.

  An object of the present invention is to provide a medical device in which a rigid tubular member such as polypropylene and a polybutadiene tube, which is a soft material, are firmly bonded, a method for firmly bonding a polybutadiene tube to the rigid tubular member, and a connection tool therefor. There is.

  The inventors of the present invention have made various studies in order to solve the above problems. As a result, the styrene-butadiene copolymer having a butadiene unit content of 5 to 45% by weight, preferably 10 to 40% by weight, or the copolymer The inventors have found that the composition of the coalescence and polystyrene is excellent in moldability, hardness, and solvent adhesiveness with the polybutadiene tube, and have reached the present invention.

That is, the present invention provides a medical device in which a second tubular member made of a polybutadiene soft material is joined to a connection tool provided at an end of a first tubular member made of a thermoplastic hard material having a melting point of 90 ° C. or higher. The connecting device is a medical device comprising a styrene-butadiene copolymer having a butadiene content of 5 to 45% by weight or a composition of the copolymer and polystyrene.
The present invention also provides a styrene-butadiene copolymer having a butadiene content of 5 to 45% by weight or the copolymer at the end of the first tubular member made of a thermoplastic hard material having a melting point of 90 ° C. or higher. A medical device manufacturing method comprising: fitting a connector including a composition with polystyrene; and joining a second tubular member made of a soft material of polybutadiene to the connector using a solvent.

  Furthermore, the present invention is a connection tool for joining a first tubular member made of a thermoplastic hard material having a melting point of 90 ° C. or more and a second tubular member made of a soft material of polybutadiene, and having a butadiene content of 5 to 45 weight. % Styrene-butadiene copolymer or a composition of the copolymer and polystyrene.

  In the present invention, since a styrene-butadiene copolymer is used as a connector, a first tubular member (a thermoplastic having a melting point of 90 ° C. or higher) that is a hard material and a second tubular member (polybutadiene tube) that is a soft material are used. Can be joined firmly.

  In the present invention, the first tubular member made of a hard material is a tubular member, and it is necessary to have an end portion (for example, a small-diameter tubular projecting portion) capable of fitting a connection tool at the end portion. Such tubular members include infusion circuits, infusion bags or infusion tubes. As a material of such a member, there is a tubular member formed from a thermoplastic having a melting point of 90 ° C. or higher, for example, polypropylene, ethylene-propylene copolymer, polypropylene and polypropylene elastomer and the like. In particular, polypropylene which is widely used as a hard material is preferable.

A specific example of the first tubular member will be described using an infusion tube shown in FIG. FIG. 2 is a schematic view of the drip tube 1, FIG. 3 is an enlarged cross-sectional view of the lower portion (leg part) of the drip tube, and FIG. 4 is a bottom view of the drip tube. The drip tube main body 1 has a chemical solution outlet, a small-diameter tubular protrusion 4 constituting a part of the chemical outlet, and a large-diameter annular protrusion 6 concentrically arranged on the outer side. Further, a recess 5 is formed between the small-diameter tubular protrusion 4 and the large-diameter tubular protrusion 6 (FIG. 3). The small-diameter tubular projecting portion 4 becomes a connecting fixture fixing inner wall, the large-diameter tubular projecting portion 6 becomes a connecting fixture fixing outer wall, and the concave portion 5 is a place where the connecting fixture is fitted.
The leg is a tapered small-diameter tubular protrusion, a cylindrical hollow tubular connector 3 made of a styrene-butadiene copolymer or a composition of the copolymer and polystyrene, and a connector fixing inner wall 4 for fixing and holding the connector. And a connector fixing outer wall 6. The convex part front-end | tip part 7 of the connection tool 3 made from the styrene-butadiene copolymer is inserted in the annular clearance concave part 5 of the connection tool fixing inner wall 4 and the connection tool fixing outer wall 6 (FIG. 5). The distal end portion of the connecting fixture fixing outer wall 6 may be bent by an ultrasonic welding machine, a hot plate press or the like, and the connecting fixture 3 may be attached (FIG. 6). In this case, it is preferable that the connector 3 is provided with a recess that fits into the bent portion.

  Examples of drip tube materials generally include polypropylene, ethrene-propylene copolymer, and a blend of polypropylene and polypropylene elastomer. The drip tube has an outer diameter of about 14-17 mm, an inner diameter of about 13-16 mm, and a length of about 50-70 mm. The small-diameter tubular protrusion 4 constituting the leg has an outer diameter of about 2 to 4 mm, an inner diameter of about 1 to 3 mm, and a length of about 5 to 20 mm. The thickness of the connecting fixture fixing inner wall 4 constituting the legs for holding the connecting fixture 3 is about 1 to 2 mm, the length is about 1 to 3 mm, and the thickness of the connecting fixture fixing outer wall 6 is about 1 to 2 mm. The length is about 2-5 mm. The annular clearance recess 5 between the connecting fixture fixing inner wall 4 and the connecting fixture fixing outer wall 6 constituting the recess has a clearance width of about 0.5 to 2 mm. These dimensions are examples and do not limit the present invention.

In the present invention, the second tubular member made of a soft material includes polybutadiene. The polybutadiene is a polymer obtained by polymerizing syndiotactic 1,2-polybutadiene alone, a copolymer obtained by copolymerizing the polymer, or a composition containing these polymers or copolymers as a main component. A copolymer obtained by copolymerizing styrene with tactic 1,2-polybutadiene, or a blend of a styrene elastomer such as styrene-isoprene-styrene is also included. It is desirable that 1,2-polybutadiene accounts for 50 to 100 mol% in the copolymer, and the polymer or copolymer is desirably contained in the composition in an amount of 50 to 100% by weight. The tube has an outer diameter of 2-5 mm, an inner diameter of about 1-4 mm, and a length of about 100 cm to 200 cm. In the present invention, a soft polybutadiene tube having a hardness of 80 to 90 A according to JISK6301 is preferred. A polybutadiene tube having a hardness of 95A or more according to JISK6301 has a drawback that it is hard and easily bends. The inner diameter, outer diameter, and length of the tube can be arbitrarily selected according to the purpose of use.
The inner diameter, outer diameter, and length of the tube can be arbitrarily selected according to the purpose of use.

In the present invention, the connector provided at the end of the first tubular member is a tubular hollow tube having a portion that can be joined to the first tubular member and a portion that can join the second flexible tubular member together with the chemical solution outlet. The shape and size of the connecting member are not particularly limited.
An example of the shape is shown in FIGS. Such a connecting tool 3 has a chemical liquid channel communicating with the chemical liquid outlet of the first tubular member 1 at the center, and a connector fixing inner wall 4 and a connector fixing outer wall 6 of the first tubular member 1 at the upper end of the chemical liquid channel. A thick convex portion 7 is formed which is concentric with and in contact with the tip, and whose tip portion protrudes outward. The convex portion 7 is fitted into the annular gap concave portion 5 of the first tubular member. After the fitting, if necessary, a part of the connector fixing outer wall 6 may be melted, and the convex portion 7 may be caulked by the melted portion. An annular rib 8 that can lock the second tubular member 9 may be formed in the middle portion of the chemical liquid flow path of the connector 3. The connector 3 is a rigid cylindrical hollow tube having an outer diameter of about 4 to 8 mm, an inner diameter of about 2 to 5 mm, and an overall length of about 8 to 12 mm. The convex portion 7 at the upper part of the inner diameter of the connector 3 has a thickness of about 0.5 to 2 mm and a width of 1 to 2 mm, and the annular rib 8 of the connector has a thickness of about 0.5 to 2 mm. The connection tool 3 may be tapered. These dimensions are examples and do not limit the present invention.
The material of the connector includes a styrene-butadiene copolymer having a butadiene content of 5 to 45% by weight or a composition of the copolymer and polystyrene.

Examples of the butadiene-styrene copolymer used in the present invention include styrene-butadiene-styrene copolymer (SBS) and styrene-butadiene copolymer (SB or SBC), and include block or random copolymers. Or the composition of these copolymers and polystyrene may be sufficient. The proportion of polystyrene varies depending on the styrene unit content in the copolymer.
In the present invention, the butadiene content refers to the butadiene content relative to the total weight of the copolymer or the copolymer and polystyrene. That is, in the present invention, a copolymer having a styrene unit content of 95 to 55% by weight and a butadiene unit content of 5 to 45% by weight or a composition of the copolymer and polystyrene, preferably a styrene unit content of 90 to 60 A copolymer having a content of 10% by weight and a butadiene unit content of 10 to 40% by weight or a composition of the copolymer and polystyrene is used. Such a styrene-butadiene copolymer or a composition of the copolymer and polystyrene is excellent in moldability, hardness, and solvent adhesion to a polybutadiene tube. When the butadiene unit content exceeds 45% by weight, adhesiveness and flexibility are generated, and the mold release property during molding is poor. Further, when the butadiene unit content is less than 5% by weight, the solvent adhesion to the polybutadiene tube (evaluated by the tensile adhesive strength) is less than the strength that cannot be practically used.

  Instead of the styrene-butadiene-styrene copolymer or the composition of the copolymer and polystyrene, transparent ABS, methyl methacrylate (MMA), methyl methacrylate of acrylonitrile-butadiene-styrene-methyl methacrylate copolymer -Butadiene-Styrene (MBS), Styrene, Styrene-Ethylene-Propylene-Styrene (SEPS), Polycarbonate, Solvent Bonding of Hard Tubular First Member and Polybutadiene Tube, and Measurement by Tensile Bond Strength There was a drawback that the polybutadiene tube of the part was not easily broken without breaking and could not be put to practical use.

As an embodiment of the medical device of the present invention, there is a medical device used for instillation injection or the like in which the hard first tubular member shown in FIG. 1 is an infusion tube 1 and the soft second tubular member is a polybutadiene tube 9. . Basically, it has an introduction needle 2 that pierces the infusion container at the top of the infusion tube 1, a polybutadiene tube 9 is joined to the bottom of the infusion tube 1, and a venous needle 13 is attached to the other end of the polybutadiene tube 9. Join the freelock connector 12. Furthermore, it comprises a clamp 11 which is attached to the tube 9 on the downstream side of the infusion tube 1 and adjusts the flow rate of the infusion flowing through the tube. In general, in order to accurately infuse an infusion, an infusion pump 10 capable of managing and adjusting the infusion rate and the amount of infusion is provided in the polybutadiene tube 9 between the infusion tube 1 and the freelock connector 12.
The drip tube 1 as the first tubular member is a molded product made of a thermoplastic having a melting point of 90 ° C. or higher, and the side wall has flexibility and transparency. Therefore, the transparent drip tube 1 can reliably drop the drip liquid from the outlet during the drip. Specifically, the drip tube 1 is connected to the main body, and the upper end of the main body is connected to the introduction needle 2 that is pierced through the hermetic stopper of the infusion container, and the lower portion has a tapered tube and a leg portion that follows it. In the present invention, the drip tube 1 and the polybutadiene tube 9 are joined by a connector made of a styrene-butadiene copolymer.

In order to perform infusion using the medical device of the present invention, first, the door of the infusion pump 10 is opened, the power switch of the infusion pump 10 is turned on without the polybutadiene main tube 9 being attached, While the tube 9 is closed, the introduction needle 2 provided in the infusion tube 1 is pierced through the rubber stopper of the infusion container, and priming is performed while pushing the infusion tube 1 back and forth by hand. 3 accumulate. Next, the clamp 11 is opened, the infusion solution is filled up to the tip of the venous needle 13, and the clamp 11 is closed. Next, the tube clamp 11 installed in the infusion pump 10 is released, the polybutadiene main tube 9 between the infusion tube 1 and the clamp 11 is attached to the infusion pump 10, the door of the infusion pump 10 is closed, and the infusion flow rate is set. After setting the total amount (planned amount) of the infusion to be instilled, the clamp 11 is opened, and after confirming that there is no infusion of the infusion in the infusion tube 1 and at the tip of the vein needle 13, the vein needle 13 is punctured and the infusion pump Press the 10 start switch to start the infusion supply. Polybutadiene main tube 9 during the infusion supply is occluded polybutadiene main tube when broken or in accidents, takes a sudden pressure in the tube, the connection portion of the drip chamber 1 and the polybutadiene main tube 9 is pressure load of polybutadiene tubing 9 Although there is a risk of easily coming off due to expansion due to (rising), in the present invention, a styrene-butadiene-styrene copolymer that can be firmly joined (adhered) to the polybutadiene main tube is used as a connecting part, so these risks are avoided. it can.

In the method for producing a medical device of the present invention, a connecting tool is fitted to a tubular projecting portion provided at an end of a first tubular member made of a hard material, and the second tubular member made of a soft material is connected to the connecting tool. Are bonded with a solvent.
Examples of the solvent used in the present invention include solvent-type adhesives such as cyclohexane, cyclohexanone, ethyl acetate, methyl ethyl ketone, and tetrahydrofuran.

As an embodiment of the method of the present invention, a styrene-butadiene copolymer is formed in an annular gap recess 5 located between a small-diameter tubular protrusion 4 and a large-diameter tubular protrusion 6 below a polypropylene rigid tubular member (drip tube). The convex portion 7 of the connector 3 molded in step 1 is inserted and firmly joined by hot pressing. The joining method may be an ultrasonic wave described in the method of JP-A-63-283651.
Next, the polybutadiene tube 9 wetted with a solvent (cyclohexane, cyclohexanone, ethyl acetate, etc.) whose outer surface is solvent-bonded to styrene-butadiene is inserted into the annular rib 8 while contacting the inner surface of the connector 3, and the connector 3 Adhere with solvent. The reason for providing the annular rib 8 is that when a tensile force is intentionally applied to the polybutadiene tube 9, the diameter of the polybutadiene tube at the solvent joint portion is reduced to prevent the infusion volume from changing, and even if the ultrasonic bonding is insufficient. There is an advantage that the infusion from the drip tube is difficult to leak.

Example 1
(A) Preparation of sample for evaluation From the composition (samples A to F) of the styrene-butadiene copolymer shown in Table 1 and Table 3 or the copolymer and polystyrene in various blending ratios, an inner diameter of about 3.6 mm, A cylindrical hollow tube with an outer diameter of about 6.6 mm, a wall thickness of about 1.5 mm, and a length of about 8 mm is injection-molded under conditions of a cylinder temperature of 170 to 200 ° C. and a mold temperature of 20 to 25 ° C. An evaluation sample was produced.
Using a single screw extruder, a polybutadiene tube having an outer diameter of about 3.6 mm and an inner diameter of about 2.3 mm was extruded at a cylinder temperature of 130 to 150 ° C. to produce a tube cut to a length of about 10 cm.
(B) Polybutadiene tube solvent adhering method At about 23 ° C., a polybutadiene tube having a surface coated with cyclohexanone of about 8 mm from the tip of the tube is inserted into the end of the cylindrical hollow tube, ie, about 8 mm. After standing at a room temperature of about 23 ° C. for 1 to 2 days, it was heat-treated in a dry heat dryer at about 60 ° C. for about 24 hours and left at a room temperature of about 23 ° C. for over 1 day.
(C) Tube Adhesive Evaluation Method Using the cylindrical hollow tube and polybutadiene tube prepared above, the maximum tensile strength of the inner diameter portion of the cylindrical hollow tube and the solvent-bonded polybutadiene tube is about 23 ° C., manufactured by Shimadzu Corporation. Measured with a universal testing machine (model: AG-500D). The results are shown in Tables 2 and 4.
(C) -1 Maximum tensile strength measurement conditions Measurement conditions: A stainless steel test holder having a thickness of about 4 mm with a circular hole of φ3.8 mm in the center is attached to the upper chuck of the tensile tester, and a cylindrical hollow tube is inserted into the hole. Through a polybutadiene tube inserted and bonded into the tube, the maximum tensile strength was measured at a pulling speed of 500 mm / min and a tube test length of 40 mm.
(C) -2 Evaluation of Maximum Tensile Bond Strength Satisfying both the following criteria (1) and (2): ○ (pass)
What does not satisfy both of the following criteria (1) or (2): x (failed)
(1) Tube tensile average maximum strength 4 Kg or more (2) The tube is broken in the hollow cylindrical shape in the tube rupture state after the tube tensile maximum strength test.
(D) Evaluation of injection moldability of cylindrical hollow tube In the injection molding of various resins, relative evaluation was made with an injection molding resin generally used.
No problem with mold release time, appearance of cylindrical hollow tube, etc.
Adhesive, long mold release time, cylindrical hollow tube appearance spots: ×

Comparative Example 1
Using the transparent molding material (sample) shown in Table 5, a cylindrical hollow tube having an inner diameter of about 3.6 mm, an outer diameter of about 6.6 mm, a wall thickness of about 1.5 mm, and a length of about 8 mm is molded. Polybutadiene tube (outside diameter: about 3.6 mm, inside diameter: about 2.3 mm, length: about 10 cm) with cyclohexanone applied to the empty tube at room temperature (23 ° C.) about 8 mm from the tip of the tube. Inserted into part 8 mm (inside swallow), left at room temperature of about 23 ° C. for 1-2 days, heat-treated in a dry heat dryer at about 60 ° C. for about 24 hours, and at room temperature of about 23 ° C. for over 1 day I left it alone. The tensile bond strength between the hollow cylindrical tube and the polybutadiene tube was measured with a universal testing machine (model: AG-500D) manufactured by Shimadzu Corporation. The solvent adhesion method and measurement conditions of the polybutadiene tube are the same as the tube adhesion evaluation method of the example.
These results are shown in Tables 1 to 4 (present invention) and Tables 5 and 6 (Comparative Examples).

  Styrene-butadiene copolymer: KK38 is styrene / butadiene = 70/30 (weight ratio), and KR05 is styrene / butadiene = 75/25 (weight ratio).

  Styrene / butadiene weight ratio; D-KX405 = 24/76, D-KX408 = 43/57

  As is apparent from Tables 1 to 6, the cylindrical hollow tube (connector) of the present invention has a high maximum tensile bond strength (Kg) with the polybutadiene tube, and the tube bonded portion after the tube tensile test is less broken. And it is excellent in tube adhesiveness and moldability.

It is the schematic which shows the medical device of this invention. It is an external view which shows the infusion tube of the medical device shown in FIG. 1, and the introduction needle joined to it. It is a drip pipe lower part sectional view shown in FIG. FIG. 2 is a bottom view of the drip tube shown in FIG. 1. It is sectional drawing which shows a drip pipe lower part and the connector joined to it. It is sectional drawing which shows a drip pipe lower part and the connector joined to it.

Explanation of symbols

1 Infusion tube 2 Introducing needle 3 Connection tool 4 Small-diameter tubular protrusion (connector fixing inner wall)
5 annular gap (concave)
6 Large-diameter tubular projection (outer wall for fixing fixture)
7 Convex part 7 of connector
8 Annular rib of connector 9 Polybutadiene tube 10 Infusion pump 11 Clamp 12 Free lock connector 13 Intravenous needle

Claims (8)

A connector provided at the end of the first tubular member made of polypropylene, an ethylene-propylene copolymer, or a blend of polypropylene and polypropylene elastomer, which is a thermoplastic hard material having a melting point of 90 ° C. or higher, is made of a soft material of polybutadiene. 2. A medical device in which two tubular members are joined, wherein the connector includes a styrene-butadiene copolymer having a butadiene content of 5 to 45% by weight or a composition of the copolymer and polystyrene. .   The medical device according to claim 1, wherein the first tubular member is an infusion circuit, an infusion bag, or an infusion tube.   The medical device according to claim 1, wherein the second tubular member is a polybutadiene tube having a hardness of 80 to 90A according to JISK6301. Styrene having a butadiene content of 5 to 45% by weight at the end of the first tubular member made of polypropylene, an ethylene-propylene copolymer or a blend of polypropylene and polypropylene elastomer, which is a hard material of a thermoplastic having a melting point of 90 ° C. or higher A medical device characterized by fitting a connector containing a butadiene copolymer or a composition of the copolymer and polystyrene, and joining a second tubular member made of a soft polybutadiene material to the connector with a solvent. Tool manufacturing method. The method for manufacturing a medical device according to claim 4 , wherein the first tubular member is an infusion circuit, an infusion bag, or an infusion tube. The method for producing a medical device according to claim 4 , wherein the solvent is a solvent-type adhesive. The method for producing a medical device according to claim 4 , wherein the solvent is cyclohexane, cyclohexanone, ethyl acetate, methyl ethyl ketone, or tetrahydrofuran. A connector for joining a first tubular member made of polypropylene, an ethylene-propylene copolymer or a blend of polypropylene and polypropylene elastomer, and a second tubular member made of a soft material of polybutadiene, which are hard materials of thermoplastics having a melting point of 90 ° C. or higher. And a styrene-butadiene copolymer having a butadiene content of 5 to 45% by weight or a composition of the copolymer and polystyrene.

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