WO2014046950A1 - Fiole pour médicament et assemblages d'injecteur et procédés d'utilisation - Google Patents

Fiole pour médicament et assemblages d'injecteur et procédés d'utilisation Download PDF

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Publication number
WO2014046950A1
WO2014046950A1 PCT/US2013/059359 US2013059359W WO2014046950A1 WO 2014046950 A1 WO2014046950 A1 WO 2014046950A1 US 2013059359 W US2013059359 W US 2013059359W WO 2014046950 A1 WO2014046950 A1 WO 2014046950A1
Authority
WO
WIPO (PCT)
Prior art keywords
vial
bladder
needle
assembly
injection
Prior art date
Application number
PCT/US2013/059359
Other languages
English (en)
Inventor
Michael D. Hooven
Matthew J. Huddleston
David Stefanchik
Original Assignee
Enable Injections, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enable Injections, Llc filed Critical Enable Injections, Llc
Priority to US14/423,938 priority Critical patent/US20150217058A1/en
Publication of WO2014046950A1 publication Critical patent/WO2014046950A1/fr
Priority to US15/481,753 priority patent/US10729842B2/en
Priority to US16/923,612 priority patent/US20200338257A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2459Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/152Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags pressurised by contraction of elastic reservoirs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles

Definitions

  • This disclosure relates generally to vials for medical liquids, such as drugs, antibiotics, or other liquids for medical therapeutic or diagnostic purposes, and to injection apparatus for injecting the vial contents. More specifically, this subject matter relates to such vials, which can be pre-filled with medical liquid and that can expel substantially all the contents, preferably at a generally constant flow rate, and to injection apparatus or assemblies for use with such vials and to methods of filling and using such vials and apparatus.
  • Figure 1 is a cross-sectional view of a preferred embodiment of the present invention. In this view, the vial assembly is shown in the unfilled state.
  • Figure 2 is a cross-sectional view of a preferred embodiment of the present invention. In this view, the vial assembly is shown in the filled state.
  • Figures 3 - 4 are cross-sectional views of the vial assembly being filled with a syringe and vial adapter. The vial assembly is shown in the unfilled state in
  • Figure 5 is a perspective view of the preferred embodiment of the present invention. In this view the filled vial assembly is being inserted into the injector assembly.
  • Figure 6 is cross-sectional view of Figure 5.
  • Figures 7 - 14 are cross-sectional views of the preferred embodiment of the present invention of the injector assembly with vial assembly in place showing different sequences during the injection.
  • Figure 15 is a perspective view of the preferred embodiment of the present invention of the injector assembly being removed from the injection surface after delivery of the liquid.
  • Figure 16 is a perspective view of an alternative embodiment. In this view the filled vial assembly is being inserted into the injector assembly.
  • Figure 17 is cross-sectional view of Figure 1 6.
  • Figure 18 - 22 are cross-sectional views of an alternative embodiment of the injector assembly with vial assembly in place showing different sequences during the injection.
  • Figure 23 is a perspective view of an alternative embodiment of the injector assembly being removed from the injection surface after delivery of the liquid.
  • Figure 24 is a perspective view of an alternative embodiment of an injector assembly. In this view the filled vial assembly is being inserted into the injector assembly.
  • Figure 25 is cross-sectional view of Figure 24.
  • Figure 26 - 29 are cross-sectional views of an alternative embodiment of the injector assembly with vial assembly in place showing different sequences during the injection.
  • Figure 30 is a perspective view of an alternative embodiment of the injector assembly being removed from the injection surface (e.g. patient's skin) after delivery of the liquid.
  • Figure 31 is a perspective view of a vial such as in Figure 1 and a filling apparatus or spike for introducing medical liquid into the vial.
  • Figure 32 is a cross-sectional perspective view of the vial of Figure 31 with filling apparatus fully inserted.
  • Figure 33 is a cross-sectional perspective view of the vial of Figure 32, with the filling apparatus partially withdrawn or partially inserted.
  • Figure 34 is a cross-sectional perspective view of the vial of Figure 33, with the filling apparatus further withdrawn or less inserted.
  • the vial assembly 5 may include a vial 1 , outer stopper/bladder 2, inner plug 3 and crimp cap 4.
  • the vial 1 may be constructed from glass or plastic and range in volume from 1 ml_ to 10mL
  • the crimp cap 4 can be constructed from plastic, aluminum or steel and may include an optional pop-off safety tab.
  • the crimp cap 4 could fit a range of vial neck sizes from 13 to 32 mm in diameter.
  • the outer stopper/bladder 2 (also known as the outer expanding element or balloon) and inner plug 3 can be made from blended synthetic rubber. They may also be independently different materials. This could include one or more of the following in different concentrations: bromobutyl, chlorobutyl, isoprene,
  • the outer stopper/bladder 2 and inner plug 3 may be made from a thermoplastic elastomer.
  • the outer stopper/bladder 2 may have irregular wall thickness both in the axial and circumferential direction including ribs or grooves to provide intended variations in stress as a function of strain. This would allow for control over the pressure profile to control the delivery flow rate as a function of diameter extension.
  • the assembly of the vial 1 may include a sub-assembly of the inner plug 3 and outer stopper/bladder 2 prior to insertion into the vial 1.
  • the outer stopper/bladder 2 can be assembled into the vial 1 and then the inner plug 3 assembled into the outer stopper/bladder 2.
  • the crimp cap 4 is placed onto the vial 1.
  • the crimp force applied by the crimp cap 4 can be varied to achieve different compression forces on the outer stopper/bladder 2 and inner plug 3 assembly. This may allow for control of the seal performance or venting function.
  • the inner plug 3 is configured or sized to provide a pre-stress on the outer stopper/bladder 2 to control the pressure profile as well as to aid in delivery of all or substantially all of the liquid contained within the outer stopper/bladder 2, preferably at about a constant flow rate for most of the injection.
  • a pre-stress between the inner plug 3 and outer stopper/bladder 2 can be created by making the outer diameter of the inner plug 3 larger than inner diameter of the outer stopper/bladder 2.
  • the inner plug 3 could be a solid piece of material or could be expandable element to control the amount of pre-stress. Gas or liquid could be introduced into a void formed within the inner plug 3 to change its outer diameter or length thus causing varying amounts of pre-stress. Alternatively or additionally, pre-stress can be created by making the inner plug 3 longer than the outer stopper/bladder 2.
  • liquid 18 is contained within a space formed between the inner plug 3 and outer stopper/bladder 2.
  • the outer stopper/bladder 2 expands like a balloon and applies a uniform pressure on the liquid 18 within this space 2.
  • the shape of the outer stopper/bladder 2 when filled can be spherical or cylindrical. Cylindrical shapes allow for the same stresses as presented in a spherical shape but with more volume.
  • the outer stopper/bladder 2 is configured with a ring 6 to provide a seal against the inside of the vial 1.
  • the inner plug 3 and outer stopper/bladder 2 are configured to fit together to provide multiple seals between the inner plug 3 and outer stopper/bladder 2.
  • Seals 17 may be configured in a tongue-and-groove or other interlocking system to provide a sealing function.
  • a seal 17 is provided by the compression of the crimp cap 4 on the inner plug 3 and outer stopper/bladder 2 against the vial 1.
  • a seal may be formed by the interference between the inner plug 3 and outer stopper/bladder 2.
  • a user filled system may include the vial assembly 5 connected to a vial adapter 28 and syringe 26.
  • the syringe 26 and vial adapter 28 is assembled to an empty vial assembly 5.
  • the spike on the vial adapter 28 pierces the solid rubber section of the inner plug 3.
  • the liquid 18 is manually transferred to the vial assembly 5 between the outer stopper/bladder 2 and the inner plug 3 by the user depressing the plunger 27 of the syringe 26 causing the outer stopper/bladder 2 to inflate like a balloon.
  • the syringe 26 and vial adapter 28 are removed. This would be considered filling under liquid pressure.
  • a vacuum could be formed in the space between the outer
  • the injector assembly 6 for injecting the contents of the vial assembly 5 described earlier preferably, but not exclusively, includes a vial holder 7, needle hub 8, needle 25, adhesive 9, outer housing 10, safety pin 11 , double-sided tape 12, bandage 13 and outer bandage cover 14. Additionally, the injector assembly 6 could have the vent needle 15.
  • the vial holder 7 allows for containment of the vial assembly 5 and interfaces with the needle hub 8, outer housing 10 and safety pin 11 . There are cutouts 19 in the side of the vial holder 7 to allow for viewing of the vial assembly 5. Alternatively, the vial holder 7 may have transparent viewing windows. This allows for viewing the vial assembly 5 to confirm the proper dose has been delivered.
  • the needle hub 8 allows for containment of the needle 25 and interfaces with the vial holder 7, adhesive 9 and inner plug 3.
  • the needle hub 8 can move relative the vial holder 7 and inner plug 3 and allows for communication of the needle 25 with the liquid 18 in the outer stopper/bladder 2 during dispense.
  • the needle hub 8 may also have the ability for rotational movement to dislocate the needle 25 during removal of the injector assembly 6 for needle stick safety.
  • the needle 25 interfaces with the adhesive 9, needle hub 8, bandage 13 and inner plug 3.
  • the needle 25 pierces the solid rubber portion of the inner plug 3 to allow for communication of the liquid 18 contained within the outer stopper/bladder 2 during dispense.
  • the needle 25 pierces the bandage 13 during activation of the injector assembly 6 prior to dispense of the liquid.
  • the adhesive 9 is used to bond the needle 25 to the needle hub 8. This adhesive 9 could be for example, epoxy or cyanoacrylate and be air, moisture or UV cured.
  • the outer housing 10 interfaces with the vial holder 7, needle hub 8, safety pin 11 and double-sided tape 12. It provides the means to locate the injector assembly 6 onto the skin surface.
  • the safety pin 11 prevents inadvertent advancement of the vial holder 7 relative to the outer housing 10 prior to intended use of the injector assembly 6.
  • the safety pin 11 interfaces with the outer housing 10 and vial holder 7.
  • the safety pin 11 can be configured to allow for radial and rotational movement relative to the outer housing 10.
  • the double-sided tape 12 allows for attachment of the outer housing 10 to the skin surface. It also holds the bandage 13 to the outer housing 10 until the outer housing 10 is removed from the skin surface.
  • the bandage 13 allows for wound protection after the injector assembly 6 is removed from the skin surface.
  • the bandage 13 interfaces with the outer housing 10, double-sided tape 12 and the outer bandage cover 14.
  • the adhesion force between the bandage 13 and the skin surface is greater than the adhesion force between the bandage 13 and the double-sided tape 12. This allows for removal of the injector assembly 6 from the skin surface without removal of the bandage 13.
  • the double-sided tape 12 interfaces with the outer housing 10, bandage 13 and outer bandage cover 14.
  • the outer bandage cover 14 provides for protection of the bandage 13 and double-sided tape 12 prior to use of the injector assembly 6.
  • the outer bandage cover 14 is removed prior to use of the injector assembly 6 and interfaces with the double-
  • the vial assembly 5 is inserted into the injector assembly 6 until snaps 24 in the vial holder 7 interface with the crimp cap 4 on the vial assembly 5 to prevent it from being removed.
  • the top of the vial assembly 5 may be flush with the top of the vial holder 7 allowing for one method of verification that the vial assembly 5 is sufficiently inserted into the injector assembly 6.
  • the vial holder 7 or vial assembly 5 cannot advance relative to the outer housing 10 as the safety pin 11 keeps them from advancing. Cutouts 19 in the vial holder 7 allow the user to view the inside of the vial assembly 5.
  • the outer bandage cover 14 is removed from the bottom of the injector assembly 6. It is ready to be attached to the skin surface 16.
  • the injector assembly 6 can be attached to the skin surface 16.
  • the double-sided tape 12 will provide the adhesion force between the outer housing 10 and the skin surface 16.
  • the safety pin 11 is removed from the injector assembly 6 and it is ready for actuation.
  • Detent features 21 in the vial holder 7 and outer housing 10 prevent the vial holder 7 from moving relative to the outer housing 10 without user intervention.
  • the user pushes down on the vial holder 7 to begin inserting the needle 25 into the skin surface 16.
  • Ramp features (over-center mechanism) 22 in the vial holder 7 and outer housing 10 allow for relatively small applied force by the user to produce a relatively large axial movement of the vial holder 7 into the outer housing 10.
  • Axial movement of the vial holder 7, vial assembly 5, needle hub 8 and needle 25 (in unison) continues until the needle hub 8 bottoms out on the outer housing 10.
  • a latch/lockout 23 releases the vial holder 7 for an additional small movement to allow the needle 25 to pierce the solid section of the inner plug 3 and allowing communication of the needle 25 with the liquid in the outer stopper/bladder 2.
  • the latch/lockout 23 allows for complete needle 25 travel into the skin surface 16 before the start of dispense.
  • the needle 25 enters the liquid space within a cutout 19 in the inner plug 3. This small amount of motion also allows the vent needle 15 to pierce the wall of the outer stopper/bladder 2 to allow for venting of the space between the outer stopper/bladder 2 and the inside of the vial 1.
  • Cutouts 19 in the vial holder 7 allow the user to visually confirm the entire amount of liquid was dispensed.
  • the dispense is completed and the user begins to remove the injector assembly 6 by pulling up on the vial holder 7.
  • the adhesion force between the double-sided tape 12 and the skin surface 16 holds the outer housing 10 to the skin surface 16.
  • Axial movement of the vial holder 7, vial assembly 5, needle hub 8 and needle 25 (in unison) continues relative to the outer housing 10 until the needle 25 is completely retracted into the outer housing 10, shielding it from the user.
  • the needle 25 may be deflected to a stored position that prevents reuse and protects against accidental needle stick by the user.
  • snaps 20 in the outer housing 10 interface with the needle 25 and needle hub 8 to move it off center, slightly bending it and locking it out from being actuated again while also providing for additional needle shielding from the user.
  • the injector assembly 6 is pulled away from the skin surface 16.
  • the bandage 13 peels away from the outer housing 10 and is left behind on the skin surface 16.
  • the vial holder and outer housing are preferably one piece, with an upper vial holder and lower base for contacting the skin of the patient. These upper and lower housing portions are hinged along an annular junction along the outer perimeter of the outer housing.
  • the needle hub 8 can be separate or configured as part of the vial holder/outer housing 17.
  • the vial assembly 5 is inserted into the injector assembly 6 until snaps 17 in the vial holder/outer housing 7 interface with the crimp cap 4 on the vial assembly 5 to prevent it from being removed.
  • the vial access end of the needle 3 is in communication with the liquid (drug, antibiotic or other medicament) 18 when the vial assembly 5 is inserted into the injector assembly 6.
  • the injection end of the needle 3 is embedded in an elastomeric needle shield 10 which prevents liquid 9 from coming out of the needle 3.
  • the vial assembly 5 cannot advance relative to the vial holder/outer housing 7 as the safety pin 11 keeps them from advancing.
  • the injector assembly 6 is also covered with an outer bandage cover 14.
  • Axial movement of the contact surface 15 allows for axial movement of the vial holder/outer housing 7, vial assembly 5, needle hub 8 and needle 3 until the needle 3 is completely retracted into the vial holder/outer housing 7, embedding the needle 3 back into the needle shield 10, shielding it from the user.
  • the bandage 13 peels away from the vial holder/outer housing 7 and is left behind on the skin surface 16.
  • the vial holder 7 and the outer housing 10 are joined by a flexible hinge 17.
  • the injector assembly 6, as seen in Figure 25, has three relatively moveable that can pivot relative to one another including a vial holder 7, a needle hub 8, needle 21 and the outer housing 10.
  • the vial assembly 5 is inserted into the injector assembly 6 until snaps 20 in the vial holder 7 interface with the crimp cap 4 on the vial assembly 5 to prevent it from being removed.
  • the vial holder 7 cannot advance relative to the outer housing 10 as the safety pin 11 keeps it from advancing.
  • the bottom of the outer housing 10 is covered with an outer bandage cover 14.
  • the outer bandage cover 14 is removed from the bottom or base of the injector assembly 6. It is ready to be attached to the skin surface 16.
  • the double-sided tape 12 will provide the adhesion force between the outer housing 10 and the skin surface 16.
  • the safety pin 11 is removed from the injector assembly 6 and it is ready for actuation.
  • the user pushes down on the vial holder 7 to begin inserting the needle 21 into the skin surface 16. Slight rotational movement of the vial holder 7, vial assembly 5, needle hub 8 and needle 21 (in unison) about the flexible hinge 17 continues until the needle hub 8 bottoms out on the outer housing 10.
  • An additional small movement allows the needle 21 to pierce the solid section of the inner plug 3 allowing communication of the needle 21 with the liquid 9 in the outer stopper/bladder 2.
  • the needle 21 enters the liquid space within a cutout 19 in the inner plug 3. This small amount of motion also allows the vent needle 15 to pierce the wall of the outer stopper/bladder 2 to allow for venting of the space between the outer
  • a filling apparatus 29 such as a filling needle, vial adapter spike or other means of filling may be used to introduce liquid 18 into the outer stopper/bladder 2 of the vial assembly 5.
  • a filling apparatus 29 may have one or more slots 30 integral to its body 32, and communicating with an internal fill path that extends to a fill inlet that may be a luer port or other inlet.
  • a fill inlet that may be a luer port or other inlet.
  • one and preferably two or more inner seals 31 may be configured into the inner stopper or plug 3 to interface with the body or shaft 32 of the filling apparatus 29 during filling and subsequent removal of the body 32 of the filling apparatus 29.
  • multiple inner seals 31 may be configured with an axial spacing to cover the slot 30 of the body 32 of the filling apparatus 29 to prevent loss of internal pressure or liquid 18 within the outer stopper/bladder 2 during the filling process.
  • multiple inner seals 31 may be configured with an axial spacing to prevent communication between the internal space of the outer stopper/bladder 2 and the ambient environment resulting in loss of pressure or liquid 18 through the slot 30 of the body 32 of the filling apparatus 29 during retraction after filling.
  • the tip 33 of the filling apparatus 29 is shown fully inserted into the inner plug 3.
  • the filling apparatus 29 is in communication with the outer stopper/bladder 2 and the inner seals 31 prevent loss of internal pressure or liquid 18 within the outer
  • stopper/bladder 2 for sealing the pressure in the bladder as the fill apparatus or spike is retracted out of the filled pressurized bladder volume while maintaining a seal between the spike and ambient pressure.
  • the distance or zone between two inner seals is greater than the length of slots 30, whereby the fill apparatus or spike is sealed at at least one location, such as proximal to the slots or distal to the slots, as the spike is inserted or retracted.
  • the filling apparatus 29 is partially withdrawn from the inner plug 3 of the vial assembly 5.
  • the filling apparatus 29 is in communication with the outer stopper/bladder 2.
  • the top of the slot 30 of the body 32 of the filling apparatus 29 is covered by the upper inner seal 31 to prevent loss of internal pressure or liquid 18 within the outer stopper/bladder 2 during withdraw of the filling apparatus.
  • the filling apparatus 29 is further withdrawn from the inner plug 3 of the vial assembly 5.
  • the top of the slot 30 of the body 32 of the filling apparatus 29 is exposed to the ambient environment but the tip 33 of the filling apparatus 29 is sealed by the lower inner seal 31 . This prevents communication between the filling apparatus 29 and outer stopper/bladder 2 and thus prevents loss of internal pressure or liquid 18 within the outer stopper/bladder 2 during withdraw of the filling apparatus 29.
  • a vial subassembly comprising a resilient bladder and a pre-stress member within the bladder
  • a slotted fill apparatus or spike in combination with plural internal vial seals that define a seal zone between the seals longer than the spike slots(s) to seal the bladder during insertion and withdrawal of the spike.
  • (A) provide for injection of substantially all the vial contents, preferably at least 95% and more preferably at least 99%; (B) provide for injection of most of the vial contents at substantially constant flow rates;
  • (C) provide for sequential steps or stages in the injection assembly for advancing a vial from a loading configuration to an injection configuration
  • (K) allow pre-stress of the vial bladder to be changed by changing the size or configuration of a pre-stress member located within the bladder;

Abstract

L'invention concerne une fiole pour médicament liquide pourvue d'une cellule interne souple et d'un élément de précontrainte localisé avec la cellule. Des assemblages d'injecteur sont aussi divulgués pour l'injection des contenus de la fiole dans un patient en avançant la fiole à travers une série d'étapes ou positions. L'invention concerne aussi des procédés de remplissage et d'utilisation.
PCT/US2013/059359 2012-09-24 2013-09-12 Fiole pour médicament et assemblages d'injecteur et procédés d'utilisation WO2014046950A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US14/423,938 US20150217058A1 (en) 2012-09-24 2013-09-12 Medical vial and injector assemblies and methods of use
US15/481,753 US10729842B2 (en) 2012-09-24 2017-04-07 Medical vial and injector assemblies and methods of use
US16/923,612 US20200338257A1 (en) 2012-09-24 2020-07-08 Medical vial and injector assemblies and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261704922P 2012-09-24 2012-09-24
US61/704,922 2012-09-24

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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1762259E (pt) 2005-09-12 2010-12-10 Unomedical As Insersor para um conjunto de infusão com uma primeira e uma segunda unidades de mola
JP2013523233A (ja) 2010-03-30 2013-06-17 ウノメディカル アクティーゼルスカブ 医療デバイス
WO2012123274A1 (fr) 2011-03-14 2012-09-20 Unomedical A/S Système d'insertion doté d'une protection pour son transport
CN103957962B (zh) 2011-10-05 2017-07-07 犹诺医药有限公司 用于同时插入多个经皮部分的插入物
EP2583715A1 (fr) 2011-10-19 2013-04-24 Unomedical A/S Système de tube de perfusion et procédé de fabrication
WO2017004345A1 (fr) 2015-06-30 2017-01-05 Kaleo, Inc. Auto-injecteurs destinés à l'administration d'un médicament à l'intérieur d'une seringue pré-remplie
EP3405230A1 (fr) 2016-01-19 2018-11-28 Unomedical A/S Canule et dispositifs de perfusion
US10688244B2 (en) 2016-12-23 2020-06-23 Kaleo, Inc. Medicament delivery device and methods for delivering drugs to infants and children
BR112020007429B1 (pt) * 2017-10-16 2023-11-07 Enable Injections, Inc Dispositivo de transferência para transferência de um fluido médico de um frasco para um dispositivo de injeção de fluido médico
EP3539596A1 (fr) * 2018-03-15 2019-09-18 Tecpharma Licensing AG Ensemble pour un dispositif d'injection ou de perfusion
WO2020236796A1 (fr) 2019-05-20 2020-11-26 Unomedical A/S Dispositif de perfusion rotative et méthodes associées
WO2021030210A1 (fr) 2019-08-09 2021-02-18 Kaleo, Inc. Dispositifs et procédés de distribution de substances dans une seringue pré-remplie
WO2022137182A1 (fr) 2020-12-23 2022-06-30 Tolmar International Limited Systèmes et procédés de combinaison d'ensembles valve de seringue
WO2023034826A1 (fr) * 2021-08-31 2023-03-09 Aktivax, Inc. Agencement d'emballage pour un agent bénéfique
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US11964121B2 (en) * 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09201396A (ja) * 1996-01-26 1997-08-05 Kawasumi Lab Inc 薬剤溶解キット及び薬剤溶解・注入システム
US20050277895A1 (en) * 2000-08-02 2005-12-15 Becton, Dickinson And Company Pen needle and safety system
US20070244457A1 (en) * 2006-04-12 2007-10-18 Fangrow Thomas F Vial adaptor for regulating pressure
WO2011123659A1 (fr) * 2010-04-01 2011-10-06 Enable Injections, Llc Dispositif et système d'injection de fluide médical
US8070739B2 (en) * 2005-08-11 2011-12-06 Medimop Medical Projects Ltd. Liquid drug transfer devices for failsafe correct snap fitting onto medicinal vials

Family Cites Families (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2584397A (en) 1945-10-03 1952-02-05 Louis K Pitman Apparatus for transferring liquid from one container to another
US2737948A (en) 1954-08-23 1956-03-13 Pfizer & Co C Disposable cartridge for hypodermic syringe
US3016895A (en) 1958-08-01 1962-01-16 Pan American Lab Inc Injector for subcutaneous implantation of solids
US2941531A (en) 1958-08-26 1960-06-21 Roehr Products Company Inc Hypodermic needle assembly
US3089491A (en) 1961-08-24 1963-05-14 Mirow Nathan Cartridge seal and needle holder with air-lock device
US3094988A (en) * 1961-09-18 1963-06-25 Dunmire Hannah Hypodermic ampoules
NL296017A (fr) 1962-08-03 1900-01-01
US3608550A (en) 1969-05-07 1971-09-28 Becton Dickinson Co Transfer needle assembly
US3797490A (en) * 1971-02-11 1974-03-19 Ampoules Inc Hypodermic ampoule with skin tensioning clip
US4201207A (en) 1973-03-26 1980-05-06 Alza Corporation Bladder for liquid dispenser
US3993069A (en) 1973-03-26 1976-11-23 Alza Corporation Liquid delivery device bladder
US3941171A (en) 1973-07-05 1976-03-02 Ims Limited Fluid transfer device
US3938520A (en) 1974-06-10 1976-02-17 Abbott Laboratories Transfer unit having a dual channel transfer member
US4031889A (en) 1975-03-25 1977-06-28 William Floyd Pike Power operated aspirating hypodermic syringe
US4386929A (en) 1980-01-18 1983-06-07 Alza Corporation Elastomeric bladder assembly
US4337769A (en) 1980-08-01 1982-07-06 Baxter Travenol Laboratories, Inc. Pressure infusion module
US4387833A (en) 1980-12-16 1983-06-14 Container Industries, Inc. Apparatus for containing and dispensing fluids under pressure and method of producing same
US4525164A (en) 1981-04-24 1985-06-25 Biotek, Inc. Wearable medication infusion system with arcuated reservoir
US4419096A (en) 1982-02-22 1983-12-06 Alza Corporation Elastomeric bladder assembly
EP0165926B1 (fr) 1983-05-20 1990-10-24 Bengt Gustavsson Dispositif pour le transfert d'une substance
US4537593A (en) 1983-06-06 1985-08-27 Becton, Dickinson And Co. Self-venting, non-coring needle assembly
US4743243A (en) 1984-01-03 1988-05-10 Vaillancourt Vincent L Needle with vent filter assembly
US4583971A (en) 1984-02-10 1986-04-22 Travenol European Research And Development Centre (Teradec) Closed drug delivery system
US4543101A (en) 1984-03-28 1985-09-24 Adria Laboratories, Inc. Valve device to aid in reconstituting injectable powders
US4619651A (en) 1984-04-16 1986-10-28 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
US4702397A (en) 1984-09-18 1987-10-27 Infusion Systems Corporation Pressurized fluid dispenser
DE3510166A1 (de) 1985-03-21 1987-01-22 Tecnotrans Ag Umfuellverschluss fuer chemisch-pharmazeutische substanzen und verfahren zu seiner herstellung
US5263935A (en) * 1986-11-26 1993-11-23 Baxter International Inc. Pressurized fluid dispenser
CA1283827C (fr) 1986-12-18 1991-05-07 Giorgio Cirelli Dispositif pour l'injection de formules liquides
US4734092A (en) 1987-02-18 1988-03-29 Ivac Corporation Ambulatory drug delivery device
US4886495A (en) 1987-07-08 1989-12-12 Duoject Medical Systems Inc. Vial-based prefilled syringe system for one or two component medicaments
US5411499A (en) 1988-01-25 1995-05-02 Baxter International Inc. Needleless vial access device
US4823623A (en) 1988-04-06 1989-04-25 Norton Company Device for transfer of fluid into sealable vials
US5011477A (en) 1989-04-21 1991-04-30 Baxter International Inc. Continuous/bolus infusor
US5205820A (en) 1989-06-16 1993-04-27 Science, Incorporated Fluid delivery apparatus
US5122116A (en) 1990-04-24 1992-06-16 Science Incorporated Closed drug delivery system
US5045064A (en) 1990-06-01 1991-09-03 Infusaid, Inc. Constant pressure implantable pump reservoir
US5527288A (en) * 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
US5709668A (en) 1991-01-16 1998-01-20 Senetek Plc Automatic medicament injector employing non-coring needle
US5360410A (en) 1991-01-16 1994-11-01 Senetek Plc Safety syringe for mixing two-component medicaments
US5298023A (en) 1991-03-08 1994-03-29 Habley Medical Technology Corporation Multiple pharmaceutical dispenser with accumulator
US5167641A (en) 1991-05-29 1992-12-01 Arnis, Inc. Auto-retracting needle injector system
US5298025A (en) 1991-07-08 1994-03-29 Baxter International Inc. Sequential flow rate infusion rate
US5329976A (en) 1991-12-09 1994-07-19 Habley Medical Technology Corporation Syringe-filling and medication mixing dispenser
US5354278A (en) 1992-04-17 1994-10-11 Science Incorporated Fluid dispenser
US5226900A (en) 1992-08-03 1993-07-13 Baxter International Inc. Cannula for use in drug delivery systems and systems including same
US5429607A (en) 1994-03-09 1995-07-04 I-Flow Corporation Elastomeric syringe actuation device
US5466220A (en) 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
DE4414697C2 (de) 1994-04-27 1998-06-18 Caremed Vertriebsgesellschaft Vorrichtung zum Transferieren und Entnehmen von Flüssigkeiten aus Flaschen, Beuteln oder ähnlichen Behältnissen für medizinische Zwecke
DE4436350C1 (de) 1994-10-12 1996-02-29 Fresenius Ag Implantierbares medizinisches Gerät
CA2159052C (fr) 1994-10-28 2007-03-06 Rainer Alex Dispositif d'injection
US5993421A (en) 1994-12-02 1999-11-30 Science Incorporated Medicament dispenser
US5503628A (en) 1995-03-15 1996-04-02 Jettek, Inc. Patient-fillable hypodermic jet injector
US6293159B1 (en) 1995-05-01 2001-09-25 Science Incorporated Fluid delivery apparatus with reservoir fill assembly
US5962794A (en) 1995-05-01 1999-10-05 Science Incorporated Fluid delivery apparatus with reservior fill assembly
CA2151407A1 (fr) 1995-06-09 1996-12-10 Duncan Newman Dispositif d'injection
US5722956A (en) 1995-08-24 1998-03-03 The General Hospital Corporation Multi-dose syringe driver
WO1997020536A1 (fr) 1995-12-06 1997-06-12 Gabriel Meyer Dispositif pour la preparation d'une solution medicamenteuse reconstituee a partir de deux composants
ZA9610374B (en) 1995-12-11 1997-06-23 Elan Med Tech Cartridge-based drug delivery device
US5785688A (en) 1996-05-07 1998-07-28 Ceramatec, Inc. Fluid delivery apparatus and method
US6045534A (en) 1997-10-27 2000-04-04 Sarcos, Inc. Disposable fluid injection module
IT236231Y1 (it) 1997-11-24 2000-08-08 Eurospital S P A Dispositivo di collegamento di due contenitori di prodottifarmaceutici per effettuare il mescolamento dei prodotti in sistema
US6090092A (en) 1997-12-04 2000-07-18 Baxter International Inc. Sliding reconstitution device with seal
AU738058B2 (en) 1997-12-16 2001-09-06 Meridian Medical Technologies, Inc. Automatic injector
US5957895A (en) 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
US6209738B1 (en) 1998-04-20 2001-04-03 Becton, Dickinson And Company Transfer set for vials and medical containers
JP2000046360A (ja) 1998-07-29 2000-02-18 Hitachi Ltd 天井埋込形の室内機
US6022339A (en) 1998-09-15 2000-02-08 Baxter International Inc. Sliding reconstitution device for a diluent container
FR2783430B1 (fr) 1998-09-23 2000-12-29 Yves Jean Soulas Dispositif torique d'injection securise par aiguille rabattable
CA2350706A1 (fr) 1998-11-13 2000-05-25 Elan Pharma International Limited Administration de medicament et systeme a cet effet
US6719719B2 (en) 1998-11-13 2004-04-13 Elan Pharma International Limited Spike for liquid transfer device, liquid transfer device including spike, and method of transferring liquids using the same
US20040069044A1 (en) 1999-04-29 2004-04-15 Gilad Lavi Device for measuring a volume of drug
DE10009814B4 (de) 2000-03-01 2008-03-06 Tecpharma Licensing Ag Einweg-Injektorkappe
US6485461B1 (en) 2000-04-04 2002-11-26 Insulet, Inc. Disposable infusion device
US6547764B2 (en) 2000-05-31 2003-04-15 Novo Nordisk A/S Double pointed injection needle
US6790199B1 (en) 2000-09-28 2004-09-14 North American Medical Products, Inc. Needle protective assembly for multi-draw needle
ES2278016T3 (es) 2001-04-09 2007-08-01 Novartis Vaccines And Diagnostics, Inc. Compuestos guanidino como agonistas del receptor de melanocortina 4 (mc4-r).
US20060122577A1 (en) 2001-09-26 2006-06-08 Poulsen Jens U Modular drug delivery system
CA2475573C (fr) 2002-02-11 2013-03-26 Antares Pharma, Inc. Injecteur intradermique
ES2673480T3 (es) 2002-03-26 2018-06-22 Becton, Dickinson And Company Dispositivo de suministro de fluido por etapas múltiples y método
GB0208627D0 (en) 2002-04-16 2002-05-22 Imprint Pharm Ltd Needle
US6960192B1 (en) 2002-04-23 2005-11-01 Insulet Corporation Transcutaneous fluid delivery system
US7250037B2 (en) 2002-07-22 2007-07-31 Becton, Dickinson And Company Patch-like infusion device
US7637891B2 (en) * 2002-09-12 2009-12-29 Children's Hospital Medical Center Method and device for painless injection of medication
EP3597262B1 (fr) 2002-12-20 2023-12-27 Xeris Pharmaceuticals, Inc. Formulation pour injection intracutanée
ES2293105T3 (es) 2003-03-06 2008-03-16 Csl Behring Gmbh Dispositivo de transferencia, en particular para fluidos medicinales.
US7524308B2 (en) 2003-04-16 2009-04-28 Becton, Dickinson And Company Safety shielding needle assembly with passive shielding
EP1502613A1 (fr) 2003-08-01 2005-02-02 Novo Nordisk A/S Appareil avec des moyens de rétraction de l'aiguille
MXPA06001467A (es) 2003-08-12 2006-05-15 Becton Dickinson Co Dispositivo de infusion similar a un parche.
US20050070874A1 (en) 2003-09-30 2005-03-31 Hikaru Matsuda System and method for injecting liquid drug containing biological material
EP1532996A1 (fr) 2003-11-20 2005-05-25 Novo Nordisk A/S Géometrie de pointe d'aiguille non-aiguisée pour une aiguille d'injection
US7670314B2 (en) 2004-02-17 2010-03-02 Children's Hospital Medical Center Injection device for administering a vaccine
US7398802B2 (en) 2004-09-02 2008-07-15 Baker James W System for dispensing biological fluids
CN101060871A (zh) 2004-09-10 2007-10-24 贝克顿·迪金森公司 重配输注装置
CN101087626B (zh) 2004-11-24 2012-11-14 贝克顿·迪金森公司 自动复原注射器装置
US7959600B2 (en) 2004-12-30 2011-06-14 Byeong S. Chang Container closure delivery system
WO2006077262A1 (fr) * 2005-01-24 2006-07-27 Novo Nordisk A/S Dispositif medical comprenant un dispositif transcutane protege
BRPI0614025A2 (pt) 2005-01-24 2012-12-25 Antares Pharma Inc injetores de jato
US7534226B2 (en) 2005-09-26 2009-05-19 M2 Group Holdings, Inc. Dispensing fluid from an infusion pump system
WO2007053799A2 (fr) 2005-10-19 2007-05-10 Cd Solutions, Llc Appareil et procede de melange et de transfert de medicaments
WO2007066341A2 (fr) 2005-12-08 2007-06-14 Nanopass Technologies Ltd. Adaptateur de micro-aiguille pour dispositifs d’administration dosee de medicaments
GB0605763D0 (en) 2006-03-22 2006-05-03 The Technology Partnership Plc Ambulatory pump
CN101426465B (zh) 2006-04-24 2013-05-22 诺沃-诺迪斯克保健股份有限公司 由冻干药物生成药物溶液的转移系统
US8221354B2 (en) 2006-04-27 2012-07-17 Medtronic, Inc. Infusion device with positive pressure elastic bladder reservoir
US20070282269A1 (en) 2006-05-31 2007-12-06 Seattle Medical Technologies Cannula delivery apparatus and method for a disposable infusion device
US7806265B2 (en) 2006-07-12 2010-10-05 Mobius Therapeutics, Llc Apparatus and method for reconstituting a pharmaceutical and preparing the reconstituted pharmaceutical for transient application
US20100185177A1 (en) 2006-09-05 2010-07-22 Gillum Christoph L Hands-free intramuscular injection device
US8162923B2 (en) 2006-09-06 2012-04-24 Calibra Medical, Inc. Disposable infusion device with automatic unlocking mechanism
US9345831B2 (en) 2006-10-19 2016-05-24 E3D Agricultural Cooperative Association Ltd Automatic injection device
US7637889B2 (en) 2006-11-15 2009-12-29 Glynntech, Inc. Drug delivery device with sliding valve and methodology
US7938801B2 (en) 2006-11-22 2011-05-10 Calibra Medical, Inc. Disposable infusion device filling apparatus and method
WO2008067506A1 (fr) 2006-11-30 2008-06-05 Medi-Physics, Inc. Aiguille à lumière double
WO2008083209A2 (fr) 2006-12-29 2008-07-10 Amir Genosar Réservoir et appareil hypodermiques d'administration de médicament
US7540858B2 (en) 2007-01-23 2009-06-02 Becton, Dickinson And Company Retracting safety pen needle
WO2008134570A2 (fr) 2007-04-27 2008-11-06 Amylin Pharmaceuticals, Inc. Outil de mélange
US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
IL182922A0 (en) 2007-05-02 2007-09-20 Medimop Medical Projects Ltd Automatic liquid drug reconstitution apparatus
ES2444441T3 (es) 2007-06-15 2014-02-25 Lifescan, Inc. Cánula flexible o conducto de dispositivo médico
CN101918074B (zh) 2007-09-18 2013-02-27 麦迪麦珀医疗工程有限公司 药物混合及注射装置和药物混合方法
DE102007055635A1 (de) 2007-11-21 2009-05-28 Robert Bosch Gmbh System zum Verabreichen eines flüssigen Medikaments
US20100331773A1 (en) 2007-11-22 2010-12-30 Novo Nordisk Healthcare A/G Medical mixing device
DE102007061346A1 (de) 2007-12-17 2009-06-18 Bayer Schering Pharma Aktiengesellschaft Spike mit zwei Dornen
US7976505B2 (en) 2007-12-19 2011-07-12 Calibra Medical, Inc. Disposable infusion device negative pressure filling apparatus and method
US7815609B2 (en) 2007-12-19 2010-10-19 Calibra Medical, Inc. Disposable infusion device positive pressure filling apparatus and method
US8002736B2 (en) 2007-12-21 2011-08-23 Carticept Medical, Inc. Injection systems for delivery of fluids to joints
US8545440B2 (en) 2007-12-21 2013-10-01 Carticept Medical, Inc. Injection system for delivering multiple fluids within the anatomy
EP3679969A3 (fr) 2007-12-31 2020-09-30 DEKA Products Limited Partnership Ensemble pompe à perfusion
USD631153S1 (en) 2008-01-07 2011-01-18 I-Flow Corporation Elastic housing for infusion device
FR2928539B1 (fr) 2008-03-12 2012-02-24 Vygon Dispositif d'interfacage pour flacons a perforer a fins de preparations de liquides perfuses
GB2461086B (en) 2008-06-19 2012-12-05 Cilag Gmbh Int Injection device
US7927306B2 (en) 2008-06-26 2011-04-19 Calibra Medical, Inc. Disposable infusion device with prime indicator
ES2396748T3 (es) 2008-06-30 2013-02-25 Animas Corporation Microbomba volumétrica
WO2010008575A1 (fr) 2008-07-18 2010-01-21 Becton, Dickinson And Company Ensemble pompe à engrenages et double compartiment pour système d'administration sous haute pression
WO2010033795A2 (fr) 2008-09-18 2010-03-25 Becton, Dickinson And Company Injecteur médical à activation par bouton
EP2328640B1 (fr) 2008-09-18 2016-12-21 Becton, Dickinson and Company Injecteur médical équipé d'un réglage de dose post-autoreconstitution et d'un entraînement de piston automatique
ES2736182T3 (es) 2008-09-18 2019-12-26 Becton Dickinson Co Inyector médico con partes de cuerpo acopladas
US8790328B2 (en) 2008-10-15 2014-07-29 Novo Nordisk Healthcare A/G System for reconstitution of a powdered drug
US20100130958A1 (en) 2008-11-26 2010-05-27 David Kang Device and Methods for Subcutaneous Delivery of High Viscosity Fluids
EP2196231B1 (fr) 2008-12-12 2013-02-27 F. Hoffmann-La Roche AG Système de perfusion de médicament ambulatoire comportant un appareil de remplissage pour conteneurs flexibles
GB0900930D0 (en) 2009-01-20 2009-03-04 Future Injection Technologies Ltd Injection device
GB2467904B (en) 2009-02-17 2013-06-12 Oval Medical Technologies Ltd Drug container and delivery mechanism
KR101597672B1 (ko) 2009-03-20 2016-02-25 앤태어스 파머, 인코퍼레이티드 위험 약제 주사 장치
US9345640B2 (en) 2009-04-14 2016-05-24 Yukon Medical, Llc Fluid transfer device
EP2437715B1 (fr) 2009-06-02 2018-01-17 Yukon Medical, LLC Dispositif de transfert et de distribution multiconteneurs
US8425487B2 (en) 2009-07-01 2013-04-23 Fresenius Medical Care Holdings, Inc. Drug vial spikes, fluid line sets, and related systems
JP2011083484A (ja) * 2009-10-16 2011-04-28 Toshiba Corp 経皮薬物投与装置及び経皮薬物投与ユニット
DK2319477T3 (da) 2009-11-06 2012-04-23 Hoffmann La Roche Indretning til fyldning af en fleksibel forrådsbeholder i et undertryk-kammer
US8348898B2 (en) 2010-01-19 2013-01-08 Medimop Medical Projects Ltd. Automatic needle for drug pump
EP2397169A1 (fr) 2010-06-15 2011-12-21 CSL Behring GmbH Fixation pour une seringue d'injection
WO2011156580A1 (fr) 2010-06-09 2011-12-15 Valeritas, Inc. Mécanismes de rétraction d'aiguille de dispositif d'administration de fluide, cartouches et joints fluidiques étanches extensibles
AU2011267879A1 (en) 2010-06-14 2012-12-06 David R. Duncan Medication infusion kit
JP2013533069A (ja) 2010-08-10 2013-08-22 エフ.ホフマン−ラ ロシュ アーゲー 薬物再構成および送達装置
US8523814B2 (en) 2010-09-28 2013-09-03 Covidien Lp Self-venting cannula assembly
EP2438938A1 (fr) 2010-10-11 2012-04-11 PharmaSens AG Pompe de type seringue
EP2468333A1 (fr) 2010-12-21 2012-06-27 Sanofi-Aventis Deutschland GmbH Auto-injecteur
JP6290625B2 (ja) 2011-01-17 2018-03-07 アクティヴパック, インコーポレイテッド 無菌カートリッジおよび分配装置
WO2013033421A2 (fr) * 2011-09-02 2013-03-07 Unitract Syringe Pty Ltd Mécanisme d'insertion pour une pompe d'administration de médicaments
NL2007461C2 (en) * 2011-09-23 2013-03-26 Ambro B V System for transporting fluid across or into a biological barrier, device and capsule as part of the system.
US8968242B2 (en) 2012-02-10 2015-03-03 Avent, Inc. Inflatable elastomeric pump for an infusion assembly
FR2990136B1 (fr) 2012-05-02 2015-06-19 Pharmadyne Kit de recharge d'une pompe a perfusion, methode de preparation et d'utilisation de celui-ci
EP2803348A1 (fr) 2013-05-15 2014-11-19 hameln rds gmbh Procédé de remplissage de seringues pour les pompes de dosage
EP3010568B1 (fr) 2013-06-18 2019-02-27 Enable Injections, Inc. Appareil de transfert de flacon et d'injection
EP2832390A1 (fr) 2013-07-30 2015-02-04 Sensile Pat AG Dispositif d'administration de médicament avec mécanisme d'actionnement d'aiguilles
EP2842586A1 (fr) 2013-08-27 2015-03-04 PharmaSens AG Dispositif avec moteur de type Lavet
CN106029124B (zh) 2013-12-19 2019-05-10 美敦力迷你迈德公司 贴身注射器及其使用方法
JP6616327B2 (ja) 2014-04-24 2019-12-04 ベクトン・ディキンソン・アンド・カンパニー 流体注入デバイス

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09201396A (ja) * 1996-01-26 1997-08-05 Kawasumi Lab Inc 薬剤溶解キット及び薬剤溶解・注入システム
US20050277895A1 (en) * 2000-08-02 2005-12-15 Becton, Dickinson And Company Pen needle and safety system
US8070739B2 (en) * 2005-08-11 2011-12-06 Medimop Medical Projects Ltd. Liquid drug transfer devices for failsafe correct snap fitting onto medicinal vials
US20070244457A1 (en) * 2006-04-12 2007-10-18 Fangrow Thomas F Vial adaptor for regulating pressure
WO2011123659A1 (fr) * 2010-04-01 2011-10-06 Enable Injections, Llc Dispositif et système d'injection de fluide médical

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US20200338257A1 (en) 2020-10-29
US10729842B2 (en) 2020-08-04
US20150217058A1 (en) 2015-08-06

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