WO2014023867A3 - Liposomas vacíos como adyuvante de diferentes principios activos, administrados independientemente y en su forma galénica convencional - Google Patents

Liposomas vacíos como adyuvante de diferentes principios activos, administrados independientemente y en su forma galénica convencional Download PDF

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Publication number
WO2014023867A3
WO2014023867A3 PCT/ES2013/070535 ES2013070535W WO2014023867A3 WO 2014023867 A3 WO2014023867 A3 WO 2014023867A3 ES 2013070535 W ES2013070535 W ES 2013070535W WO 2014023867 A3 WO2014023867 A3 WO 2014023867A3
Authority
WO
WIPO (PCT)
Prior art keywords
indepently
active agents
liposomes administered
encapsulation
composition
Prior art date
Application number
PCT/ES2013/070535
Other languages
English (en)
French (fr)
Other versions
WO2014023867A2 (es
Inventor
Pedro González Enseñat
Original Assignee
Enoc Solutions, S.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enoc Solutions, S.L. filed Critical Enoc Solutions, S.L.
Publication of WO2014023867A2 publication Critical patent/WO2014023867A2/es
Publication of WO2014023867A3 publication Critical patent/WO2014023867A3/es

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1277Processes for preparing; Proliposomes
    • A61K9/1278Post-loading, e.g. by ion or pH gradient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/44221,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La encapsulación de sustancias activas ha permitido mejoras en la administración de diferentes principios activos. Sin embargo, la encapsulación no está exenta de problemas. En la presente invención, se describe el uso de una composición que comprende liposomas en fase acuosa como adyuvante caracterizado porque dicha composición se combina de manera independiente con el principio activo.
PCT/ES2013/070535 2012-08-09 2013-07-19 Liposomas vacíos como adyuvante de diferentes principios activos, administrados independientemente y en su forma galénica convencional WO2014023867A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP201231287 2012-08-09
ES201231287A ES2442450B1 (es) 2012-08-09 2012-08-09 Liposomas vacíos como adyuvante de diferentes principios activos, administrados independientemente y en su forma galénica convencional

Publications (2)

Publication Number Publication Date
WO2014023867A2 WO2014023867A2 (es) 2014-02-13
WO2014023867A3 true WO2014023867A3 (es) 2014-04-03

Family

ID=49551608

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2013/070535 WO2014023867A2 (es) 2012-08-09 2013-07-19 Liposomas vacíos como adyuvante de diferentes principios activos, administrados independientemente y en su forma galénica convencional

Country Status (2)

Country Link
ES (1) ES2442450B1 (es)
WO (1) WO2014023867A2 (es)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0361894A2 (en) * 1988-09-28 1990-04-04 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Loading and controlled release of amphiphatic molecules to and from liposomes
US20030003144A1 (en) * 2001-05-01 2003-01-02 Keller Brian C. Sustained release formulations for nifedipine, dextromethorphan, and danazol
US20080044464A1 (en) * 2001-10-03 2008-02-21 Paul Tardi Liposome loading with metal ions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9000207A (es) * 1990-01-29 1991-08-16 Duphar Int Res
ES2196978B1 (es) * 2001-10-26 2005-03-16 Universitat Autonoma De Barcelona Composicion farmaceutica.
EP1750673B1 (en) * 2004-05-17 2009-12-02 Tekmira Pharmaceuticals Corporation Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof
EP3153159A1 (en) * 2004-07-09 2017-04-12 Robert Sabin Compositions comprising a copper compound for treatment of mammalian diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0361894A2 (en) * 1988-09-28 1990-04-04 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Loading and controlled release of amphiphatic molecules to and from liposomes
US20030003144A1 (en) * 2001-05-01 2003-01-02 Keller Brian C. Sustained release formulations for nifedipine, dextromethorphan, and danazol
US20080044464A1 (en) * 2001-10-03 2008-02-21 Paul Tardi Liposome loading with metal ions

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"Adjuvant", 12 October 2013 (2013-10-12), pages 1 - 3, XP002718158, Retrieved from the Internet <URL:http://en.wikipedia.org/wiki/Adjuvant> [retrieved on 20131217] *
KUCHERYANU ET AL: "Effect of liposomes containing L-DOPA on mice behaviour in experimental Parkinsonian syndrome", PHARMACOLOGICAL RESEARCH, ACADEMIC PRESS, LONDON, GB, vol. 31, 1 January 1995 (1995-01-01), pages 106, XP022358806, ISSN: 1043-6618, DOI: 10.1016/1043-6618(95)86682-5 *
LUDEWIG<A> B ET AL: "In vivo antigen loading and activation of dendritic cells via a liposomal peptide vaccine mediates protective antiviral and anti-tumour immunity", VACCINE, ELSEVIER LTD, GB, vol. 19, no. 1, 15 August 2000 (2000-08-15), pages 23 - 32, XP004228807, ISSN: 0264-410X, DOI: 10.1016/S0264-410X(00)00163-8 *
XIANG YU ET AL: "Chlorotoxin-modified stealth liposomes encapsulating levodopa for the targeting delivery against the Parkinson's disease in the MPTP-induced mice model", JOURNAL OF DRUG TARGETING, vol. 20, no. 1, January 2012 (2012-01-01), pages 67 - 75, XP009175246 *

Also Published As

Publication number Publication date
ES2442450A2 (es) 2014-02-11
ES2442450B1 (es) 2014-12-12
ES2442450R1 (es) 2014-03-03
WO2014023867A2 (es) 2014-02-13

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