WO2014016816A3 - Malha polímerica com permeabilidade seletiva, para a regeneraçâo/reparação de tecidos - Google Patents

Malha polímerica com permeabilidade seletiva, para a regeneraçâo/reparação de tecidos Download PDF

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Publication number
WO2014016816A3
WO2014016816A3 PCT/IB2013/056218 IB2013056218W WO2014016816A3 WO 2014016816 A3 WO2014016816 A3 WO 2014016816A3 IB 2013056218 W IB2013056218 W IB 2013056218W WO 2014016816 A3 WO2014016816 A3 WO 2014016816A3
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WO
WIPO (PCT)
Prior art keywords
tissues
mesh
regeneration
repair
polymeric mesh
Prior art date
Application number
PCT/IB2013/056218
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English (en)
French (fr)
Other versions
WO2014016816A2 (pt
Inventor
Albino Manuel PEREIRA MARTINS
Marta Luísa SOUSA DIAS ALVES DA SILVA
Rui Luís GONÇALVES DOS REIS
Nuno João MELEIRO ALVES DAS NEVES
Original Assignee
Association For The Advancement Of Tissue Engineering And Cell Based Technologies And Therapies - A4Tec
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Association For The Advancement Of Tissue Engineering And Cell Based Technologies And Therapies - A4Tec filed Critical Association For The Advancement Of Tissue Engineering And Cell Based Technologies And Therapies - A4Tec
Priority to ES13783091.5T priority Critical patent/ES2659489T3/es
Priority to US14/411,433 priority patent/US20160038645A1/en
Priority to EP13783091.5A priority patent/EP2878314B1/en
Publication of WO2014016816A2 publication Critical patent/WO2014016816A2/pt
Publication of WO2014016816A3 publication Critical patent/WO2014016816A3/pt
Priority to US15/993,020 priority patent/US20180272038A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/225—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/64—Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/10—Materials or treatment for tissue regeneration for reconstruction of tendons or ligaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/22—Materials or treatment for tissue regeneration for reconstruction of hollow organs, e.g. bladder, esophagus, urether, uterus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

O presente pedido descreve uma malha polimérica para reparação ou regeneração de tecidos de um organismo que compreende poros em que pelo menos 70% dos poros da referida malha têm tamanho inferior ao requerido para confinar as células dos referidos tecidos, e em que pelo menos 70% dos poros da referida malha tem um tamanho superior ao necessário para a passagem de fluídos intersticiais dos referidos; em que o tempo de degradação da referida malha polimérica no organismo é de pelo menos 8 semanas; a referida malha polimérica possui uma resistência à tensão superior a 1 MPa e um módulo de elasticidade aparente superior a 0.1 MPa. A malha descrita neste pedido permite que o "novo tecido" tenha propriedades muito semelhantes ao tecido lesado. Desta forma, a malha polimérica para a reparação/regeneração de tecidos descrita no presente pedido, pode ser utilizada em medicina em combinação ou não com métodos cirúrgicos, nomeadamente no tratamento de doenças que envolvem a reparação ou regeneração de tecidos em particular quando os tecidos a tratar são pele, cartilagem, ligamento periodontal ou submocosas do esófago.
PCT/IB2013/056218 2012-07-27 2013-07-29 Malha polímerica com permeabilidade seletiva, para a regeneraçâo/reparação de tecidos WO2014016816A2 (pt)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES13783091.5T ES2659489T3 (es) 2012-07-27 2013-07-29 Malla polimérica con permeabilidad selectiva, para la reparación y la regeneración de tejidos
US14/411,433 US20160038645A1 (en) 2012-07-27 2013-07-29 Polymeric mesh with selective permeability, for the repair and regeneration of tissues
EP13783091.5A EP2878314B1 (en) 2012-07-27 2013-07-29 Polymeric mesh with selective permeability, for the repair and regeneration of tissues
US15/993,020 US20180272038A1 (en) 2012-07-27 2018-05-30 Polymeric mesh with selective permeability, for the repair and regeneration of tissues

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT10646412 2012-07-27
PT106464 2012-07-27

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/411,433 A-371-Of-International US20160038645A1 (en) 2012-07-27 2013-07-29 Polymeric mesh with selective permeability, for the repair and regeneration of tissues
US15/993,020 Continuation US20180272038A1 (en) 2012-07-27 2018-05-30 Polymeric mesh with selective permeability, for the repair and regeneration of tissues

Publications (2)

Publication Number Publication Date
WO2014016816A2 WO2014016816A2 (pt) 2014-01-30
WO2014016816A3 true WO2014016816A3 (pt) 2014-03-20

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PCT/IB2013/056218 WO2014016816A2 (pt) 2012-07-27 2013-07-29 Malha polímerica com permeabilidade seletiva, para a regeneraçâo/reparação de tecidos

Country Status (5)

Country Link
US (2) US20160038645A1 (pt)
EP (1) EP2878314B1 (pt)
ES (1) ES2659489T3 (pt)
PT (1) PT2878314T (pt)
WO (1) WO2014016816A2 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3137906A1 (en) * 2014-04-28 2017-03-08 Association For The Advancement Of Tissue Engineering And Cell Based Technologies & Therapies (A4TEC) Polimeric substrates with immobilized antibodies and method of production thereof
CN105999368A (zh) * 2016-07-28 2016-10-12 上海建华精细生物制品有限公司 表皮生长因子复合湿性创伤敷料及其制备方法
MX2019001220A (es) 2016-08-02 2019-07-04 Fitesa Germany Gmbh Sistema y proceso para preparar telas no tejidas de acido polilactico.
US11441251B2 (en) 2016-08-16 2022-09-13 Fitesa Germany Gmbh Nonwoven fabrics comprising polylactic acid having improved strength and toughness
GB2567173A (en) * 2017-10-04 2019-04-10 Univ Oxford Innovation Ltd Cartilage plug
SG11202012857PA (en) * 2018-07-09 2021-02-25 Nat Inst Materials Science Nonwoven fabric, method for manufacturing same, and composition for electrospinning
CN109248337B (zh) * 2018-09-19 2021-03-30 深圳齐康医疗器械有限公司 一种人工真皮修复材料及其制备方法
CN111110922B (zh) * 2019-12-25 2020-10-27 四川大学 一种用于3d生物打印的牙周生物模块及构建方法及应用

Citations (3)

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JP2009101062A (ja) * 2007-10-25 2009-05-14 Unitika Ltd 鼓膜穿孔修復材料
WO2009099570A2 (en) * 2008-02-01 2009-08-13 Wake Forest University Health Sciences Aligned scaffolding system for skeletal muscle regeneration
WO2011003422A1 (en) * 2009-07-06 2011-01-13 Coloplast A/S Biodegradable scaffold for soft tissue regeneration and use thereof

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EP1160315A1 (en) * 2000-05-29 2001-12-05 Kantonsspital Basel Use of biochemical factors for tissue engineering
WO2002015952A1 (en) * 2000-08-08 2002-02-28 Bioamide, Inc. Scaffolds for tissue engineered hair

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2009101062A (ja) * 2007-10-25 2009-05-14 Unitika Ltd 鼓膜穿孔修復材料
WO2009099570A2 (en) * 2008-02-01 2009-08-13 Wake Forest University Health Sciences Aligned scaffolding system for skeletal muscle regeneration
WO2011003422A1 (en) * 2009-07-06 2011-01-13 Coloplast A/S Biodegradable scaffold for soft tissue regeneration and use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEVES S C ET AL: "Chitosan/Poly(@?-caprolactone) blend scaffolds for cartilage repair", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 32, no. 4, 1 February 2011 (2011-02-01), pages 1068 - 1079, XP027514836, ISSN: 0142-9612, [retrieved on 20101027], DOI: 10.1016/J.BIOMATERIALS.2010.09.073 *

Also Published As

Publication number Publication date
WO2014016816A2 (pt) 2014-01-30
EP2878314A2 (en) 2015-06-03
US20160038645A1 (en) 2016-02-11
US20180272038A1 (en) 2018-09-27
EP2878314B1 (en) 2017-11-29
ES2659489T3 (es) 2018-03-15
PT2878314T (pt) 2018-04-06

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