WO2014016454A1 - Aparato para la medición de la topografía y espesor de la cornea y procedimiento de medida empleado - Google Patents
Aparato para la medición de la topografía y espesor de la cornea y procedimiento de medida empleado Download PDFInfo
- Publication number
- WO2014016454A1 WO2014016454A1 PCT/ES2013/070467 ES2013070467W WO2014016454A1 WO 2014016454 A1 WO2014016454 A1 WO 2014016454A1 ES 2013070467 W ES2013070467 W ES 2013070467W WO 2014016454 A1 WO2014016454 A1 WO 2014016454A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cornea
- light
- topography
- eye
- thickness
- Prior art date
Links
- 210000004087 cornea Anatomy 0.000 title claims abstract description 139
- 238000012876 topography Methods 0.000 title claims abstract description 50
- 238000000034 method Methods 0.000 title claims abstract description 24
- 210000001508 eye Anatomy 0.000 claims abstract description 117
- 230000000007 visual effect Effects 0.000 claims abstract description 21
- 238000007689 inspection Methods 0.000 claims description 24
- 210000001747 pupil Anatomy 0.000 claims description 17
- 230000003287 optical effect Effects 0.000 claims description 5
- 230000002123 temporal effect Effects 0.000 claims description 4
- 238000003491 array Methods 0.000 claims description 3
- 238000004422 calculation algorithm Methods 0.000 claims description 3
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 238000010252 digital analysis Methods 0.000 claims description 2
- 238000005259 measurement Methods 0.000 description 10
- 238000012544 monitoring process Methods 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 206010013082 Discomfort Diseases 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 208000002177 Cataract Diseases 0.000 description 1
- 206010020675 Hypermetropia Diseases 0.000 description 1
- 201000002287 Keratoconus Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 201000009310 astigmatism Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 208000021921 corneal disease Diseases 0.000 description 1
- 201000004573 corneal ectasia Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 230000004305 hyperopia Effects 0.000 description 1
- 201000006318 hyperopia Diseases 0.000 description 1
- 238000012804 iterative process Methods 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/1005—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring distances inside the eye, e.g. thickness of the cornea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/0008—Apparatus for testing the eyes; Instruments for examining the eyes provided with illuminating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/107—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining the shape or measuring the curvature of the cornea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/113—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining or recording eye movement
Definitions
- the present invention is related to the devices and procedures used to determine optical characteristics of the eye, proposing an apparatus and a method for measuring the topography and thickness of the cornea.
- Vision is the gateway to 95% of the information we receive and, therefore, the most important route of spatial location, emotional communication, and particularly learning (for example, in relation to formal recognition skills, reading, reading comprehension, etc.), so it is convenient to perform a periodic exploration of the vision, to detect and treat the functional problems that may arise.
- the cornea is a transparent hemispheric structure located in the front of the eye, which protects the iris and the lens and allows the passage of light, with refractive properties, determining 2/3 of the focusing capacity of the human eye.
- the corneal dioptric power originates in the refraction of the anterior surface of the cornea, so that the refractive power of the cornea corresponds largely to the shape of its surface, represented by its topography.
- the measurement of the topography of the cornea and the thickness of the same allows to recognize pathologies such as astigmatisms, myopia or hyperopia, corneal ectasias such as keratoconus, keratoglobo, with allergic untivitis, to assess the conditions of the cornea before cataract surgical treatments, keratomileusis or personalized refractive surgery, study and adaptation of contact lenses, etc.
- Conventional cornea scanning devices are usually high-cost equipment, with high technical performance and high resolution, being primarily used to detect major corneal alterations or for prior eye surgery analysis.
- these devices force the patient to keep the direction of the gaze of their eyes fixed at a fixed point, since to perform the test it is essential that the measurement system is correctly aligned and focused with respect to the eye to be analyzed, it can be annoying and tedious for the patient, in many cases having to repeat the test, because the patient blinks or looks away from the indicated point.
- a low-cost device is necessary for the measurement of corneal topography and its thickness, which can be more accessible to users and even allows the patient to perform the test to discriminate whether his cornea is normal or problematic.
- an apparatus and a procedure are proposed that allow the measurement of the topography and thickness of the cornea regardless of the area where the patient's gaze is converging, so as to avoid the discomforts and discomforts of the conventional solutions
- the apparatus for measuring the topography and thickness of the cornea is constituted by a system for monitoring the direction of the patient's eyes, a corneal inspection system, a visual stimuli representation system before the eyes of the patient and a computer that is operatively connected to said systems to determine the topography and thickness of the cornea of each eye.
- the monitoring system allows to know where the direction of the patient's gaze is directed, so that the inspection system can take data from the cornea regardless of the area where the patient is fixing the direction of his gaze.
- the visual stimuli representation system before the patient's eyes may be formed by screens on which visual optotypes or stimuli are represented that allow stimulating and guiding the direction of the patient's eyes to expose different areas of the cornea, so that the inspection system can have a larger area of the cornea from which to obtain information.
- the visual stimulus representation system is formed by four LEDs positioned at strategic points is planned close to the peripheral inner part of the visual field of the patient's eyes, so that through the selective emission of light from those LEDs, the direction of the patient's eyes can be stimulated and guided.
- the system for monitoring the direction of the eyes of the patient is formed by an emitter for each eye, which emits diffused light to illuminate the cornea, and a camera associated with each eye, with which the reflections of the eye are observed. diffused light emitted.
- the inspection system is also constituted by a light emitter for each eye, which emits light beams on the cornea, and a receiver assembly that receives the light reflected by the cornea.
- the computer controls the light emitters and processes the information of each camera and the receiver set, to determine the topography and thickness of the cornea of each eye.
- the receiver assembly that receives the light reflected by the cornea is formed by a single receiver element common to both eyes, using a set of oriented mirrors that direct the light reflected by the cornea of each eye towards the single receptor element.
- the receiving assembly that receives the light reflected by the cornea can be formed by two receiving elements, each associated with an eye, each receiving element being in this case optically aligned with the direction of the look of its respective eye.
- the possibility that a set of lenses is arranged between the receiver and the eyes is also provided.
- the receiver set that receives the reflected light by the cornea it can be formed by CCD or CMOS electro-optical cameras, or it can be formed by CCD or CMOS sensor arrays.
- the light emitter of the inspection system is movable and orientable to be able to emit light beams on the cornea in different directions, so that different geometric patterns of points of incidence of the light beams emitted on the cornea can be drawn (for example, straight lines, circumferences, etc.).
- the system for monitoring the direction of the eye's gaze and the inspection system may be constituted by the same elements, so that there can be only one receiver of the light reflections produced on the cornea, making the camera the functions of the receiver set, or vice versa, there can be only one emitter that emits light on the cornea, emitting diffused light, visible light, infrared light, or others, as appropriate.
- the procedure for measuring the topography and thickness of the cornea includes the phases of:
- a low cost device is thus obtained, which due to its constructive and functional characteristics is of preferential application for the function to which it is intended in relation to the determination of the topography and thickness of the cornea of the human eye, allowing the analysis of the same in a fast and simple way, avoiding discomfort and discomfort to the patient.
- Figure 1 shows a diagram of the components that form the apparatus of the invention for measurement of the topography and thickness of the cornea.
- Figure 2 shows an illustrative example of a possible configuration of the apparatus of the invention for measuring the topography and thickness of the cornea.
- the apparatus of the invention for measuring the topography and thickness of the cornea is composed of a monitoring system (1) for the direction of the gaze (D) of the eyes (2) of a patient, an inspection system (3) of the cornea (4) of the eyes (2), a system of representation (13) of visual stimuli before the eyes (2) and a computer (5) operatively connected to said tracking systems (1), inspection (3) and representation (13) of visual stimuli.
- the tracking system (1) allows to know the instantaneous position of each eye (2) at all times, and the inspection system (3) makes the appropriate measures so that in the computer (5), depending on the information of both tracking systems (1) and inspection (3), calculate the topography and thickness of the cornea (4) regardless of the area in which the patient is fixing the direction of his gaze (D).
- the tracking system (1) of the direction of the eye look (2) includes a camera (6) and a diffused light emitter (7), for each eye (2), so that each diffused light emitter (7) sends light on your eye (2), whose reflection is captured by the corresponding camera (6) to know the direction of the eyes look (2).
- the inspection system (3) of the cornea (4) comprises, for each eye (2), a light emitter (8) that emits light beams (9) on the cornea (4) and a receiver assembly (10) that receives the light reflected by the cornea (4).
- the representation system (13) of visual stimuli can be formed by screens that represent different optotypes or visual stimuli before the eyes (2) of the patient that allow stimulating and guiding the direction of the gaze (D) of the eyes (2) of the patient to expose different areas of the cornea (4), so that the light emitter (8) of the inspection system (3) has a larger area of the cornea (4) on which to emit light information so that the computer (5) can later calculate in a more efficient way the topography and thickness of the cornea (4).
- the representation system (13) of visual stimuli is formed by four LEDs positioned at strategic points close to the peripheral interior part of the visual field of the eyes (2), so that through The selective emission of light by the LEDs can be stimulated and guide the direction (D) of the eyes look (2) of the patient.
- the computer (5) controls the light emitters (7,8) and the visual stimulus representation system (13) and processes all the information of each camera (6) and the receiver set (10), to determine the topography and thickness of the cornea (4) of each eye (2).
- the light information sent on the cornea (4) can take different forms, so that the light emitter (8) of each eye (2) emits light beams (9) that draw point to point on the cornea (4).
- multiple parallel or converging lines or point clouds can be physically represented on the cornea (4).
- Multiple sets of parallel lines can also be represented, where all sets of parallel lines converge at the same point, such as the center of the pupil or the apex of the corneal paraboloid, or where some sets of parallel lines converge at one single point and other sets converge at another or other points of convergence.
- the diffused light emitter (7) of the tracking system (1) and the light emitter (8) of the inspection system (3) emit at different light frequencies, or emit the same light frequency but in alternating periods of time.
- the light emitter (8) that emits light beams (9) on the cornea (4) can be an emitter of infrared light, collimated light, or laser light. In a possible configuration it can be a emitter that emits light in narrow beams, so that the maximum dimension of the beam section sent towards a point close to the cornea (4) is less than the minimum height between crest and valley of the corneal bulges (4) that are intended to be measured.
- the receiver assembly (10) that receives the light reflected by the cornea (4) is formed by two receptor elements, each of which is associated with an eye (2) of the patient, so that each receiving element is optically aligned with the direction of the gaze (D) of its respective eye (2) to be analyzed.
- the receiver assembly (10) that receives the light reflected by the cornea (4) is formed by a single receiver element common to both eyes (2), in which case the single receiver element is misaligned with the direction of the look (D) of the eyes (2) to be analyzed, so that to optically align it with each eye (2) a set of oriented mirrors (12) that direct the light reflected by the cornea (4) is used from each eye (2) towards the unique receptor element.
- a set of oriented mirrors (12) that direct the light reflected by the cornea (4) is used from each eye (2) towards the unique receptor element.
- the set of mirrors (12) can be used to direct the light beams (9) that the light emitter (8) sends to the cornea (4).
- a set of lenses (11) is arranged between the receiver set (10) and the eyes (2).
- one or more lenses are arranged between said single receiving element and the eyes (2) of the patient, and in the case of a receiving element for each eye (2) one or more lenses are arranged between each receiving element and the respective eye (2) of the patient.
- the receiver assembly (10) that receives the light reflected by the cornea (4) can be formed by CCD or CMOS type electro-optical cameras, so that the receiver set (10) can be constituted by two CCD or CMOS type electro-optical cameras, each one associated with one eye (2) of the patient, or a single electro-optical camera of type CCD or CMOS, associated with both eyes (2) of the patient.
- the receiver assembly (10) may be formed by arrays of sensors of the CCD or CMOS type, so that, in this case, the receiver assembly (10) may be formed by a single array of sensors of the CCD type or CMOS, associated to both eyes (2) of the patient, or by two matrices of sensors of type CCD or CMOS, each associated to one eye (2) of the patient.
- each sensor array has a flat shape and is located perpendicular to the optical axis corresponding to the eye direction (D) of the eye (2) to which it is associated.
- each sensor array is formed by a flat surface perpendicular to the optical axis corresponding to the eye direction (D) of the eye (2) to which it is associated and a cylindrical surface arranged around and at a certain distance from the eye (2) , the axis of the cylindrical surface being aligned with the direction of the gaze (D) of the eye (2).
- each sensor array is arranged around and at some distance from the eye (2), forming a spherical or parabolic shaped dome.
- the light emitter (8) of the inspection system (3) be movable and orientable, to emit light beams (9) on the cornea (4) in different directions and to be able to draw geometric patterns of points of incidence of the beam on the cornea (4) (for example, straight lines, circumferences, etc.).
- the monitoring system (1) of the direction of the gaze (D) of the eyes (2) and the inspection system (3) can be constituted by the same elements, so that there can be a single element that receives the light reflections produced on the cornea (4), the camera (6) performing the functions of the receiver assembly (10), or vice versa, there can be a single emitting element that emits light on the cornea (4), emitting diffused light, light visible, infrared light, or others as appropriate.
- the computer (5) which is operatively connected to the light emitters (7, 8) and the receiver assembly (10), is able to control the direction of each beam of light (9) sent and capture the instantaneous position of each eye (2), the instantaneous position of the reflections of each beam of light (9) on the cornea (4) and / or the shape of the reflected points of light, so that the computer (5 ), by numerical calculation and from the iterative analysis of the angles of incidence and reflection of the light beams (9) emitted and the reflections captured, it is able to calculate the topography of the cornea (4), both of its outer layer and of its inner layer, as well as its thickness along its length and width.
- the measurement procedure used to determine the topography of the cornea (4), as well as its thickness along its width comprises the following phases (the description is made based on only one of the eyes (2) of a patient) :
- the direction of gaze (D) of the eye (2) of the patient is determined, for which the center of rotation of the ocular globule and the center of the pupil are calculated, the direction of gaze (D) being the line that joins the center of rotation of the ocular globule and the center of the pupil.
- the determination of the direction of gaze (D) is performed by the tracking system (1), for which the surface of the cornea (4) of the eye (2) is illuminated by the diffused light emitter (7), subsequently the camera (6) captures the light reflected by the cornea (4) and the computer (5), by means of an automatic shape recognition software, obtains the apparent geometry of the pupil, the apparent geometry of the ocular globule (corresponding to a spheroid ) and / or the apparent geometry of the cornea (corresponding to a paraboloid). Once this information is obtained from the eye (2), the center of rotation of the ocular globule and the center of the pupil and, based on this, the direction of gaze (D) of the eye (2) is calculated.
- the way in which the direction of gaze is determined (D) is a technique known as "eyes-tracking", based on the recognition of the changes in position of the corneal reflexes produced by diffuse illuminators or by changes in apparent geometry of the pupil, so it is not going to enter to describe it in detail, since it does not enter within the scope of the invention.
- a virtual polar coordinate system is defined, whose coordinate origin coincides with the center of the pupil calculated in the previous phase.
- the image that is captured from the surface of the cornea (4) by the inspection system (3) is represented on the virtual polar coordinate system, so that measurements of the topography and thickness of the cornea can be made (4) regardless of the area where the patient is fixing his gaze, since the reference system on which the captured image is represented does not have a fixed coordinate origin but is relative depending on the direction of gaze ( D) of the patient.
- light beams (9) are sent to the cornea (9) from the light emitter (8) of the inspection system (3), so that the light spots and light spots that are reflected on the surface of The cornea (4), or on its outer and inner layers, are captured by the receiver assembly (10) of the inspection system (3).
- Each point of light and light spot is associated with the temporal moment in which it has been captured, so that when the reconstruction of the topography of the cornea is carried out, the position of the pupil center is taken into account in the temporal moment of the capture, determined by the direction of look (D) of the eyes (2) at that moment.
- the diffused light emitter (7) of the tracking system (1) and the light emitter (8) of the tracking system inspection (3) can be issued simultaneously when the emissions occur at different light frequencies, in which case the cameras (6) and the receiver assembly (10) are properly configured to discriminate the necessary light frequencies.
- the diffuse light emission of the diffused light emitter (7) is interrupted and sent to the cornea (4) light beams (9) ) from the light emitter (8) of the inspection system (3).
- the information of the points of light and light spots, captured by the receiver assembly (10) of the inspection system (3), is referenced on the polar coordinate system defined above, whereby information is obtained from the cornea (4) reference according to the direction of gaze (D) of the patient, that is to say that the information is referenced with respect to the center of the pupil of the eye (2) of the patient.
- the previous phases are repeated depending on the changes in the direction of look (D) of the patient's eye (2), until a sufficient density of points is obtained (for example, points captured by mm 2 of cornea).
- the movements of the eye and the consequent changes in the direction of look (D) of the eye (2) of the patient allow to expose different areas of the cornea (4) to the light beams (9) whose reflections are intended to capture.
- the virtual polar coordinate system is re-referenced with the new position of the pupil center and more information of the cornea (4) is collected again by means of the inspection system (3), repeating this iterative process until obtaining data of a sufficient density of points of light and luminous spots that allows to obtain the topography and thickness of the cornea (4) .
- dynamic optotypes or visual stimuli which are presented before the eyes (2) of the patient through the screens or LEDs of the visual stimulus representation system (13) can be represented during the collection of information from the cornea (4). ).
- the direction of gaze (D) of the eyes (2) of the patient can be stimulated and guided, to expose areas of the cornea to be measured in a suitable position so that the light beams ( 9) emitted by the light emitter (8).
- the dynamic opotypes can be represented on the screens (13) moving at a constant distance from the patient (that is, in the plane perpendicular to their primary gaze position) or, in cooperation with a mobile or variable focal monofocal lens, at a variable distance (that is, at different depths in the three-dimensional virtual environment).
- a topographic map of the cornea (4) is obtained, through statistical calculation algorithms based on spatial series and temporary that process the information of said points of light and luminous spots.
- the reconstruction of the topographic map of the Cornea (4) is carried out by conventional processing techniques, based on the geometric difference of the location of a real reflection point with respect to a theoretical reflection point on a perfect reference figure, usually a sphere or a paraboloid.
- the actual information obtained from the points and spots of light is compared with points of light and theoretical luminous spots obtained from the reflection on a perfectly spherical reflective surface; so that through this comparison a topographic survey of the cornea (4) can be constructed and, where appropriate, to detect anomalies in the cornea (4) analyzed.
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Abstract
Description
Claims
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR112015001574A BR112015001574A2 (pt) | 2012-07-25 | 2013-07-03 | aparelho para a medição da topografia e espessura da córnea e método de medição utilizado |
IN321KON2015 IN2015KN00321A (es) | 2012-07-25 | 2013-07-03 | |
AU2013294933A AU2013294933B2 (en) | 2012-07-25 | 2013-07-03 | Apparatus for measuring the topography and thickness of the cornea and measuring method used |
MX2015000996A MX2015000996A (es) | 2012-07-25 | 2013-07-03 | Aparato para la medicion de la topografia y espesor de la cornea y procedimiento de medida empleado. |
SG11201500503TA SG11201500503TA (en) | 2012-07-25 | 2013-07-03 | Apparatus for measuring the topography and thickness of the cornea and measuring method used |
KR1020157002947A KR20150043303A (ko) | 2012-07-25 | 2013-07-03 | 각막의 지형과 두께를 위해 측정하기 위한 장치 및 그에 사용되는 측정 방법 |
US14/415,921 US9504382B2 (en) | 2012-07-25 | 2013-07-03 | Piece of apparatus for measuring the topography and thickness of the cornea and a measuring method employed to this end |
RU2015106149A RU2015106149A (ru) | 2012-07-25 | 2013-07-03 | Секция устройства для измерения топографии и толщины роговицы и способ измерения, используемый с данной целью |
EP13822875.4A EP2878257A4 (en) | 2012-07-25 | 2013-07-03 | DEVICE FOR MEASURING THE TOPOGRAPHY AND THICKNESS OF CORNEA AND MEASURING METHOD USED |
CN201380049931.4A CN104661579A (zh) | 2012-07-25 | 2013-07-03 | 用于测量眼角膜的表面状况和厚度的一件设备以及为此所采用的测量方法 |
JP2015523581A JP2015524302A (ja) | 2012-07-25 | 2013-07-03 | 角膜の形状及び厚さを測定するための機器及び用いられる測定方法 |
CA2879596A CA2879596A1 (en) | 2012-07-25 | 2013-07-03 | Apparatus for measuring the topography and thickness of the cornea and measuring method used |
ZA2015/00369A ZA201500369B (en) | 2012-07-25 | 2015-01-19 | A piece of apparatus for measuring the topography and thickness of the cornea and a measuring method employed to this end |
IL236845A IL236845A0 (en) | 2012-07-25 | 2015-01-22 | Part of the system for measuring the topography and thickness of the cornea and the measurement method used for this |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201231191A ES2444542B1 (es) | 2012-07-25 | 2012-07-25 | Aparato para la medición de la topografía y espesor de la córnea y procedimiento de medida empleado |
ESP201231191 | 2012-07-25 |
Publications (1)
Publication Number | Publication Date |
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WO2014016454A1 true WO2014016454A1 (es) | 2014-01-30 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/ES2013/070467 WO2014016454A1 (es) | 2012-07-25 | 2013-07-03 | Aparato para la medición de la topografía y espesor de la cornea y procedimiento de medida empleado |
Country Status (19)
Country | Link |
---|---|
US (1) | US9504382B2 (es) |
EP (1) | EP2878257A4 (es) |
JP (1) | JP2015524302A (es) |
KR (1) | KR20150043303A (es) |
CN (1) | CN104661579A (es) |
AU (1) | AU2013294933B2 (es) |
BR (1) | BR112015001574A2 (es) |
CA (1) | CA2879596A1 (es) |
CL (1) | CL2015000146A1 (es) |
CO (1) | CO7180228A2 (es) |
ES (1) | ES2444542B1 (es) |
IL (1) | IL236845A0 (es) |
IN (1) | IN2015KN00321A (es) |
MX (1) | MX2015000996A (es) |
PE (1) | PE20150565A1 (es) |
RU (1) | RU2015106149A (es) |
SG (1) | SG11201500503TA (es) |
WO (1) | WO2014016454A1 (es) |
ZA (1) | ZA201500369B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2603377B1 (es) * | 2015-07-21 | 2018-01-09 | Davalor Salud, S.L. | Dispositivo electro-óptico para explorar el comportamiento de los ojos ante estímulos visuales externos |
CN112315423B (zh) * | 2020-11-06 | 2023-08-22 | 上海青研科技有限公司 | 眼球运动测量设备 |
Citations (8)
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US5204703A (en) * | 1991-06-11 | 1993-04-20 | The Center For Innovative Technology | Eye movement and pupil diameter apparatus and method |
US20030123027A1 (en) * | 2001-12-28 | 2003-07-03 | International Business Machines Corporation | System and method for eye gaze tracking using corneal image mapping |
US20090135372A1 (en) * | 2007-08-09 | 2009-05-28 | Sarver Edwin J | Modular ocular measurement system |
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EP2168474A1 (fr) * | 2008-09-25 | 2010-03-31 | ESSILOR INTERNATIONAL Compagnie Générale d'Optique | Dispositif de mesure automatique des rayons cornéens des deux yeux d'un individu |
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JPH04174639A (ja) * | 1990-11-06 | 1992-06-22 | Canon Inc | 角膜曲率測定装置 |
JP3897864B2 (ja) * | 1997-08-29 | 2007-03-28 | 株式会社トプコン | 眼科装置 |
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JP2002200045A (ja) * | 2000-10-24 | 2002-07-16 | Topcon Corp | 眼科装置 |
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JP4347599B2 (ja) * | 2003-04-10 | 2009-10-21 | オリンパス株式会社 | 個人認証装置 |
JP4541084B2 (ja) * | 2004-09-22 | 2010-09-08 | 賢治 柏木 | 眼科用検査装置 |
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US20090275929A1 (en) * | 2008-04-30 | 2009-11-05 | Amo Development, Llc | System and method for controlling measurement in an eye during ophthalmic procedure |
DE102010017837A1 (de) * | 2010-04-22 | 2011-10-27 | Carl Zeiss Meditec Ag | Anordnung zur Erzielung hochgenauer Messwerte am Auge |
JP2012143492A (ja) * | 2011-01-14 | 2012-08-02 | Nidek Co Ltd | 角膜厚測定装置 |
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2012
- 2012-07-25 ES ES201231191A patent/ES2444542B1/es active Active
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2013
- 2013-07-03 AU AU2013294933A patent/AU2013294933B2/en not_active Expired - Fee Related
- 2013-07-03 CN CN201380049931.4A patent/CN104661579A/zh active Pending
- 2013-07-03 PE PE2015000051A patent/PE20150565A1/es not_active Application Discontinuation
- 2013-07-03 CA CA2879596A patent/CA2879596A1/en not_active Abandoned
- 2013-07-03 SG SG11201500503TA patent/SG11201500503TA/en unknown
- 2013-07-03 KR KR1020157002947A patent/KR20150043303A/ko not_active Application Discontinuation
- 2013-07-03 MX MX2015000996A patent/MX2015000996A/es unknown
- 2013-07-03 WO PCT/ES2013/070467 patent/WO2014016454A1/es active Application Filing
- 2013-07-03 IN IN321KON2015 patent/IN2015KN00321A/en unknown
- 2013-07-03 BR BR112015001574A patent/BR112015001574A2/pt not_active IP Right Cessation
- 2013-07-03 RU RU2015106149A patent/RU2015106149A/ru not_active Application Discontinuation
- 2013-07-03 EP EP13822875.4A patent/EP2878257A4/en not_active Withdrawn
- 2013-07-03 JP JP2015523581A patent/JP2015524302A/ja active Pending
- 2013-07-03 US US14/415,921 patent/US9504382B2/en not_active Expired - Fee Related
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- 2015-01-21 CL CL2015000146A patent/CL2015000146A1/es unknown
- 2015-01-22 IL IL236845A patent/IL236845A0/en unknown
- 2015-01-30 CO CO15019150A patent/CO7180228A2/es unknown
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US20030123027A1 (en) * | 2001-12-28 | 2003-07-03 | International Business Machines Corporation | System and method for eye gaze tracking using corneal image mapping |
US20090135372A1 (en) * | 2007-08-09 | 2009-05-28 | Sarver Edwin J | Modular ocular measurement system |
DE102008008732A1 (de) * | 2008-02-11 | 2009-08-13 | Carl Zeiss Meditec Ag | Verfahren und Anordnung zur Bestimmung von Hornhautradien |
WO2009127442A1 (en) * | 2008-04-17 | 2009-10-22 | Vereniging Vu-Windesheim | Apparatus for corneal shape analysis and method for determining a corneal thickness |
EP2168474A1 (fr) * | 2008-09-25 | 2010-03-31 | ESSILOR INTERNATIONAL Compagnie Générale d'Optique | Dispositif de mesure automatique des rayons cornéens des deux yeux d'un individu |
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PE20150565A1 (es) | 2015-04-29 |
CA2879596A1 (en) | 2014-01-30 |
EP2878257A1 (en) | 2015-06-03 |
AU2013294933B2 (en) | 2017-04-27 |
ES2444542A1 (es) | 2014-02-25 |
AU2013294933A1 (en) | 2015-02-12 |
CL2015000146A1 (es) | 2015-05-15 |
US9504382B2 (en) | 2016-11-29 |
US20150173610A1 (en) | 2015-06-25 |
IL236845A0 (en) | 2015-03-31 |
IN2015KN00321A (es) | 2015-07-10 |
JP2015524302A (ja) | 2015-08-24 |
RU2015106149A (ru) | 2016-09-10 |
EP2878257A4 (en) | 2015-08-19 |
KR20150043303A (ko) | 2015-04-22 |
ES2444542B1 (es) | 2014-11-18 |
MX2015000996A (es) | 2015-04-09 |
BR112015001574A2 (pt) | 2017-07-04 |
CN104661579A (zh) | 2015-05-27 |
ZA201500369B (en) | 2015-12-23 |
CO7180228A2 (es) | 2015-02-09 |
SG11201500503TA (en) | 2015-04-29 |
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