WO2014001939A1 - Procédé de préparation d'agomélatine et forme cristalline i de celle-ci - Google Patents

Procédé de préparation d'agomélatine et forme cristalline i de celle-ci Download PDF

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Publication number
WO2014001939A1
WO2014001939A1 PCT/IB2013/054867 IB2013054867W WO2014001939A1 WO 2014001939 A1 WO2014001939 A1 WO 2014001939A1 IB 2013054867 W IB2013054867 W IB 2013054867W WO 2014001939 A1 WO2014001939 A1 WO 2014001939A1
Authority
WO
WIPO (PCT)
Prior art keywords
formula
compound
agomelatine
preparation
mixture
Prior art date
Application number
PCT/IB2013/054867
Other languages
English (en)
Inventor
Venkat Raman JAYARAMAN
Dineshkumar Ramabhai PANCHASARA
Ilesh Patel
Bhavesh Prajapati
Ketan Patel
Mitul Patwa
Ankit Shah
Original Assignee
Alembic Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alembic Pharmaceuticals Limited filed Critical Alembic Pharmaceuticals Limited
Publication of WO2014001939A1 publication Critical patent/WO2014001939A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/20—Preparation of carboxylic acid nitriles by dehydration of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne un procédé amélioré de préparation d'agomélatine de formule (I) et un procédé inédit de préparation de la forme cristalline I de l'agomélatine.
PCT/IB2013/054867 2012-06-30 2013-06-14 Procédé de préparation d'agomélatine et forme cristalline i de celle-ci WO2014001939A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1891MU2012 2012-06-30
IN1891/MUM/2012 2012-06-30
IN2421MU2012 2012-08-21
IN2421/MUM/2012 2012-08-21

Publications (1)

Publication Number Publication Date
WO2014001939A1 true WO2014001939A1 (fr) 2014-01-03

Family

ID=49782351

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2013/054867 WO2014001939A1 (fr) 2012-06-30 2013-06-14 Procédé de préparation d'agomélatine et forme cristalline i de celle-ci

Country Status (1)

Country Link
WO (1) WO2014001939A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107353229A (zh) * 2017-08-08 2017-11-17 许昌恒生制药有限公司 一种阿戈美拉汀中间体的制备方法
CN108264463A (zh) * 2016-12-30 2018-07-10 浙江省诸暨合力化学对外贸易有限公司 一种制备2-芳基丙二酸衍生物的方法及其应用
WO2019208807A1 (fr) 2018-04-26 2019-10-31 株式会社エーピーアイ コーポレーション Procédé de préparation de composé nitrile aromatique
CN112774869A (zh) * 2020-12-25 2021-05-11 厦门紫金矿冶技术有限公司 黄铁矿抑制剂及其制备和在铜铅锌多金属硫化矿中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194614A (en) * 1990-02-27 1993-03-16 Adir Et Compagnie Compounds having a naphthalene structure
CN1680295A (zh) * 2004-02-13 2005-10-12 瑟维尔实验室 (7－甲氧基－2－二氢－1－萘基)乙腈的新合成方法，及其在阿戈美拉汀的合成中的应用
CN101709036A (zh) * 2009-12-17 2010-05-19 天津药物研究院 阿戈美拉汀中间体2-(7-甲氧基-1-萘基)乙胺的制备

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194614A (en) * 1990-02-27 1993-03-16 Adir Et Compagnie Compounds having a naphthalene structure
CN1680295A (zh) * 2004-02-13 2005-10-12 瑟维尔实验室 (7－甲氧基－2－二氢－1－萘基)乙腈的新合成方法，及其在阿戈美拉汀的合成中的应用
CN101709036A (zh) * 2009-12-17 2010-05-19 天津药物研究院 阿戈美拉汀中间体2-(7-甲氧基-1-萘基)乙胺的制备

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108264463A (zh) * 2016-12-30 2018-07-10 浙江省诸暨合力化学对外贸易有限公司 一种制备2-芳基丙二酸衍生物的方法及其应用
CN108264463B (zh) * 2016-12-30 2021-04-09 浙江省诸暨合力化学对外贸易有限公司 一种制备2-芳基丙二酸衍生物的方法及其应用
CN107353229A (zh) * 2017-08-08 2017-11-17 许昌恒生制药有限公司 一种阿戈美拉汀中间体的制备方法
WO2019208807A1 (fr) 2018-04-26 2019-10-31 株式会社エーピーアイ コーポレーション Procédé de préparation de composé nitrile aromatique
CN112041298A (zh) * 2018-04-26 2020-12-04 株式会社Api 芳香族腈化合物的制造方法
KR20210005663A (ko) 2018-04-26 2021-01-14 가부시키가이샤 에이피아이 코포레이션 방향족 니트릴 화합물의 제조 방법
JPWO2019208807A1 (ja) * 2018-04-26 2021-04-30 株式会社エーピーアイ コーポレーション 芳香族ニトリル化合物の製造方法
JP7399850B2 (ja) 2018-04-26 2023-12-18 株式会社エーピーアイ コーポレーション 芳香族ニトリル化合物の製造方法
CN112774869A (zh) * 2020-12-25 2021-05-11 厦门紫金矿冶技术有限公司 黄铁矿抑制剂及其制备和在铜铅锌多金属硫化矿中的应用

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