WO2013191060A1 - Sonde et couvercle protecteur pour celle-ci - Google Patents

Sonde et couvercle protecteur pour celle-ci Download PDF

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Publication number
WO2013191060A1
WO2013191060A1 PCT/JP2013/066226 JP2013066226W WO2013191060A1 WO 2013191060 A1 WO2013191060 A1 WO 2013191060A1 JP 2013066226 W JP2013066226 W JP 2013066226W WO 2013191060 A1 WO2013191060 A1 WO 2013191060A1
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WO
WIPO (PCT)
Prior art keywords
light
probe
light emitting
protective member
probe according
Prior art date
Application number
PCT/JP2013/066226
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English (en)
Japanese (ja)
Inventor
剛也 阿部
和弘 広田
Original Assignee
富士フイルム株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 富士フイルム株式会社 filed Critical 富士フイルム株式会社
Publication of WO2013191060A1 publication Critical patent/WO2013191060A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01H—MEASUREMENT OF MECHANICAL VIBRATIONS OR ULTRASONIC, SONIC OR INFRASONIC WAVES
    • G01H9/00—Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by using radiation-sensitive means, e.g. optical means
    • G01H9/008—Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by using radiation-sensitive means, e.g. optical means by using ultrasonic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/22—Details, e.g. general constructional or apparatus details
    • G01N29/24—Probes
    • G01N29/2418—Probes using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/024—Mixtures
    • G01N2291/02475—Tissue characterisation

Definitions

  • the present invention relates to a probe, and more particularly to a photoacoustic probe including a light emitting unit that emits light toward a subject.
  • the present invention also relates to a protective cover for use in such a photoacoustic probe.
  • Ultrasonography is known as a type of imaging that can noninvasively inspect the internal condition of a living body.
  • an ultrasonic probe probe
  • ultrasonic waves When ultrasonic waves are transmitted from the ultrasonic probe to a subject (living body), the ultrasonic waves travel inside the living body and are reflected at the tissue interface.
  • the internal appearance can be imaged by calculating the distance based on the time it takes for the reflected ultrasound to be received by the ultrasound probe and the reflected ultrasound to return to the ultrasound probe.
  • photoacoustic imaging which image-forms the inside of a biological body using a photoacoustic effect is known.
  • photoacoustic imaging for example, pulsed laser light is irradiated into a living body. Inside the living body, living tissue absorbs the energy of the pulsed laser light, and adiabatic expansion by the energy generates an ultrasonic wave (photoacoustic signal).
  • photoacoustic signal is detected by an ultrasonic probe or the like, and a photoacoustic image is constructed based on the detection signal, whereby visualization in the living body based on the photoacoustic signal is possible.
  • Patent Document 1 describes that a protective cover formed of resin is attached to an ultrasonic probe.
  • the piezoelectric material (PZT) used in the ultrasonic probe is very fragile due to its small thickness, and the PZT may be broken when the ultrasonic probe is dropped.
  • damage is less likely to occur by attaching a protective cover so as to cover the tip of the acoustic lens coated on the ultrasonic wave irradiation surface of the ultrasonic transducer.
  • a major difference between ultrasound imaging and photoacoustic imaging is that photoacoustic imaging requires light irradiation (light emission).
  • the light emitting surface of the light emitting unit that emits light toward the subject is stained or damaged, because the light amount of the light irradiated to the subject may be reduced.
  • protective covers attached to ultrasonic probes including those described in Patent Document 1. However, it is an ultrasonic transducer protected by a protective cover in ultrasonic imaging, and a protective cover for an ultrasonic probe used in ultrasonic imaging can not be used as it is for a photoacoustic probe.
  • the present invention aims to provide a protective cover used in a probe having a light emitting unit.
  • the present invention also provides a photoacoustic probe including such a protective cover.
  • a light emitting portion for emitting light to a subject, and an acoustic wave detection for detecting a photoacoustic wave generated in the subject after the light irradiation to the subject.
  • a probe comprising: a part; a protective member having a light transmitting property covering a light emitting surface of the light emitting part; and a protective cover having a support for supporting the protective member.
  • the protective cover can be attached to the probe such that the surface on the light emitting portion side of the protective member and the light emitting surface of the light emitting portion are parallel.
  • a hydrophilic film or a water repellent film can be formed on the surface of the protective member on the subject side.
  • a diamond-like carbon film can be formed on the light emitting surface side of the light emitting portion.
  • the light emission surface of the light emission unit is disposed adjacent to the acoustic wave detector element of the acoustic wave detection unit, and the thickness of the protective member is from one end on the acoustic wave detector element side to the other end on the opposite side to the one end
  • the protective member may be formed to decrease sequentially.
  • the “thickness” of the protective member can be defined as the distance from the surface on the light emitting portion side of the protective member to the surface on the subject side.
  • the light emitting portion may include a light guide member for guiding light incident from the light source side in the direction of the subject.
  • the refractive index of the protective member is preferably lower than the refractive index of the light guide member.
  • the protective member can be formed of a plastic material that transmits light of a predetermined range of wavelength including the wavelength of light emitted from the light emitting portion.
  • the support can be formed of plastic material or metal.
  • the protective member may have acoustic wave transparency, and may further cover the acoustic wave detection surface of the acoustic wave detection unit.
  • the protective member may have a light diffusing property.
  • the protective cover is preferably removably attached to the probe body including the acoustic wave detector.
  • the probe of the present invention may be configured to further include a sterilization treated sterile cover for housing the probe body, and the sterilization cover may be removable from the probe body integrally with the protective cover.
  • the sterile cover may be adhered to the surface on the light emitting part side of the protective cover.
  • the protective cover may be sterilized.
  • the present invention is also a protective cover for a photoacoustic probe including a light emitting portion, which supports the protective member covering a light emitting surface of the light emitting portion in a state of being attached to the photoacoustic probe.
  • a protective cover characterized by comprising a support.
  • the protective cover includes a protective member having light transparency.
  • FIG. (A) is a side view of the protective cover
  • (b) is a bottom view of the protective cover
  • (c) is a front view of the protective cover.
  • Sectional drawing which shows the protection member of a modification Sectional drawing which shows the probe of another modification.
  • Sectional drawing which shows the probe of another modification Sectional drawing which shows the probe of 2nd Embodiment of this invention.
  • FIG. 1 shows a photoacoustic measurement apparatus including a probe (ultrasound probe) according to a first embodiment of the present invention.
  • the photoacoustic measurement apparatus includes an ultrasonic probe 10, a light source unit (light source) 31, and an ultrasonic unit 32.
  • the probe 10 includes a light emitting unit that emits light toward the subject, and an acoustic wave detector (acoustic wave detecting unit) that can detect an acoustic wave (for example, an ultrasonic wave) from the subject.
  • the acoustic wave detector includes, for example, a plurality of ultrasonic transducers (acoustic wave detector elements) arranged in a single unit.
  • the protective cover 14 is attached to the probe 10.
  • the protective cover 14 is detachably attached to the main body of the probe 10 and is replaceable.
  • the light source unit 31 is, for example, a laser unit that generates pulse laser light, and generates light emitted from the probe 10 to the subject.
  • the probe 10 is connected to the light source unit 31 via the optical wiring 21.
  • the optical wiring 21 includes, for example, one or more optical fibers.
  • the optical wiring 21 is configured as, for example, a bundle fiber in which several tens of optical fibers are bundled.
  • the pulsed laser light generated by the light source unit 31 is guided to the probe 10 by the optical wiring 21, and is irradiated onto the subject from the light emitting part of the probe 10.
  • the ultrasound unit 32 is a signal processing unit, and performs various types of signal processing on the acoustic wave detected by the ultrasound probe 10.
  • the ultrasound unit 32 is connected to the probe 10 via the electrical wiring 22.
  • the detection signal of the acoustic wave detected by the probe 10 is transmitted to the ultrasound unit 32 by the electrical wiring 22 and processed by the ultrasound unit 32.
  • the ultrasound unit 32 generates a photoacoustic image based on, for example, the detected photoacoustic wave.
  • the generated photoacoustic image is displayed on a display device such as a monitor.
  • FIG. 2 shows a cross-sectional view of the ultrasound probe 10 as viewed in a direction orthogonal to the direction in which the ultrasound transducers are arranged.
  • the ultrasonic probe 10 has an electronic material 11 and a light guide plate 13.
  • the electronic material 11 includes an ultrasonic transducer 12 that constitutes an acoustic wave detector.
  • the ultrasonic transducer 12 detects the photoacoustic wave generated in the subject after the light irradiation to the subject.
  • the probe 10 may have an acoustic member such as an acoustic lens on the subject side of the ultrasonic transducer 12.
  • the electronic material 11 may include, in addition to the ultrasonic transducer 12, for example, a preamplifier that amplifies the detected ultrasonic wave.
  • the optical wiring (optical fiber) 21 guides the light emitted from the laser light source unit 31 (FIG. 1) to the probe main body.
  • the light guide plate 13 is a light guide member for guiding light from a light incident end optically coupled to the optical fiber 21 to a light emitting end disposed in the vicinity of the ultrasonic transducer 12.
  • the light guide plate 13 constitutes a light emitting portion of the probe 10.
  • the optical fiber 21 is optically coupled to, for example, a central position in the lateral direction (x direction) of the cross section of the light guide plate 13 shown in FIG.
  • the ultrasonic probe 10 includes, for example, at least two light guide plates 13, and the two light guide plates 13 are disposed adjacent to the ultrasonic transducer 12 so as to face each other across the ultrasonic transducer 12. .
  • the light guide plate 13 is formed of, for example, a glass material.
  • the protective cover 14 is replaceably attached to the probe 10.
  • the protective cover 14 has a protective member 15 that covers the end face (light emitting surface) of the light guide plate 13 and a support 16 that supports the protective member 15.
  • the protective member 15 transmits at least light irradiated to the subject.
  • the protective member 15 transmits light in a predetermined wavelength range (for example, 710 nm to 850 nm) including the wavelength of light irradiated to the subject.
  • plastic materials such as polycarbonate and acrylic, silicon rubber, urethane rubber and the like can be used.
  • the support 16 for example, plastic materials such as polycarbonate and acrylic, or metals such as stainless steel and aluminum can be used.
  • the protective member 15 and the support 16 are adhered with an adhesive, for example, and the protective member 15 and the support 16 are integrally formed.
  • the protective cover 14 is replaced with a new one, for example, after each use.
  • the protective cover 14 In the state where the protective cover 14 is attached, it is preferable that no level difference is generated on the surface of the probe 10 on the side to be in contact with the subject. By making the surface free from irregularities, the probe 10 can be easily brought into contact with the subject. In order to prevent the step between the support 16 and the protection member 15, the thickness of the support 16 at the portion to which the protection member 15 is adhered is equal to the thickness of the protection member 15 than the thickness of the other portions. It is good to keep it thin.
  • the protective member 15 may be brought into contact with the light emitting surface of the light guide plate 13.
  • the ultrasonic transducer 12 should be a subject such that the heights of the light guide plate 13 and the protective member 15 are equal. It may be made to project in the direction.
  • FIG. 3 (a) to 3 (c) show a protective cover.
  • the figure (a) is the side view which looked at the protective cover 14 from the y direction
  • (b) is the bottom view seen from the z direction
  • (c) is the front view seen from the x direction.
  • the y direction corresponds to, for example, the arrangement direction of the ultrasonic transducers in the probe 10.
  • the x direction corresponds to a direction orthogonal to the y direction in a plane parallel to the ultrasonic detection surface of the probe 10.
  • the z direction corresponds to the direction perpendicular to the ultrasonic detection surface.
  • the support 16 is fixed at a predetermined position of the probe 10 using a fixing tool such as a screw (FIG. 3 (b)).
  • the protective member 15 is larger in size than the light guide plate 13. When the size of the protective member 15 is larger than the size of the light guide plate 13, the light emission surface of the light guide plate 13 can be protected. Also, the end of the protective member 15 does not disturb the light path.
  • the refractive index of the protective member 15 is preferably lower than the refractive index of the light guide plate 13 (FIG. 2). By doing so, the total reflection component on the light emitting surface of the light guide plate 13 can be suppressed.
  • An opening is formed between the two protection members 15. This opening corresponds to a region in which the ultrasonic transducers 12 are one-dimensionally arrayed in the probe 10 (FIG. 2).
  • the ultrasonic transducer 12 may be covered with a member that transmits the photoacoustic wave.
  • the protective member 15 has a thickness of, for example, 0.5 mm or more and 5 mm or less. When the thickness of the protective member 15 is too thin, it becomes fragile when an impact or the like is applied. On the other hand, if the thickness is too thick, the attenuation of light transmitted in the direction of the object becomes large. It also leads to the occurrence of a large difference in level with the ultrasonic transducer 12.
  • the protective cover 14 is preferably attached to the probe 10 such that the light incident surface (surface on the light guide plate 13 side) of the protective member 15 is parallel to the light output surface of the light guide plate 13.
  • FIG. 4 is an enlarged view of the light guide plate 13 and the protective member 15.
  • a hydrophilic film (hydrophilic coating) 17 having hydrophilicity can be formed on the surface of the protective member 15 on the subject side.
  • the hydrophilic film 17 is formed of a hydrophilic agent that transmits light in a predetermined wavelength range including the wavelength of light irradiated to the subject.
  • the hydrophilic film 17 When the hydrophilic film 17 is not formed, when water (a substance such as a liquid having light permeability) adheres to the surface of the protective member 15 on the subject side, a round water droplet may be formed. When a round shaped water droplet adheres to the surface of the protective member 15, the water droplet has a lens effect, and light emitted from the protective member 15 may be condensed to cause uneven illumination. By forming the hydrophilic film 17 on the surface of the protective member 15, it is possible to prevent the water droplet having a round shape from adhering to the surface of the protective member 15 on the subject side.
  • a water repellent film (water repellent coating) having water repellency is formed instead of the hydrophilic film 17, it is possible to prevent the adhesion of water droplets similarly.
  • a coating means described in JP-A-2011-121357 can be used for the water repellent coating. That is, oxygen plasma is applied to the protective member 15 which is a substrate to form an outer portion having a higher density than the inner portion of the substrate, and the outer surface of the formed outer portion is made of non-woven material such as Teflon (registered trademark) and fluorocarbon polymer.
  • a water repellent film may be formed by applying a wettable coating.
  • an antireflective film (AR coat) 18 that suppresses reflection of light in a predetermined wavelength range can be formed.
  • the anti-reflection film 18 in particular when the refractive index of the protective member 15 is higher than the refractive index of the light guide plate 13, light reflection on the surface of the light incident side of the protective member 15 is suppressed to make the object It can suppress that the light irradiated is reduced.
  • Either the water repellent film or the hydrophilic film and the antireflective film, or both of them may be omitted.
  • a hard film (DLC: diamond like carbon film) 19 having light transparency may be formed on the light emitting surface of the light guide plate 13.
  • DLC diamond like carbon film
  • the protective cover 14 includes the protective member 15 having light transparency, and the protective cover 14 is attached to the probe 10 so that the protective member 15 covers the light emitting surface of the light guide plate 13 of the probe 10. .
  • the protective cover 14 By covering the light emitting surface of the light guide plate 13 with the protective member 15, the light emitting surface of the light guide plate 13 can be prevented from being scratched or soiled.
  • the protective member 15 has been described above as a rectangular parallelepiped member, the shape of the protective member 15 is not limited to the rectangular parallelepiped shape.
  • the protective member of a modification is shown in FIG.
  • the protective member 15 has a thickness (from the surface on the light emitting portion side of the protective member to the surface on the subject side) from one end adjacent to the ultrasonic transducer 12 to the other end according to the position in the x direction (FIG. 2) (1) may be formed to decrease sequentially. In this case, light can be bent to the ultrasonic transducer 12 side.
  • the light guide plate 13 does not have to be disposed perpendicularly to the ultrasonic detection surface, and may be disposed obliquely. By arranging obliquely, it is possible to irradiate light immediately below the ultrasonic transducer 12.
  • the protective member for protecting the light emitting portion may be formed of a material having light transparency and acoustic wave transparency.
  • FIG. 6 shows a cross section of the probe when the protective member has light transparency and acoustic wave transparency.
  • a coupling member 20 which transmits both light and an acoustic wave (ultrasound) is used as a protective member of the protective cover 14.
  • the coupling member 20 is, for example, a water bag in which water is put in a polyethylene bag.
  • Sonagel manufactured by Takiron Co., Ltd.
  • the protective member may cover the ultrasonic transducer 12 in addition to the light emitting portion, and there is no need to provide an opening immediately below the ultrasonic transducer 12.
  • the coupling member 20 is attached to the probe using the support 16.
  • the coupling member 20 may be attached directly to the probe.
  • FIG. 7 shows an example in which the support is omitted.
  • the inner side (the side attached to the probe 10) of the coupling member 20 has adhesiveness, and can be independently attached to the side surface of the probe 10 or the like. In this case, the support can be omitted.
  • a configuration in which the protection member doubles as a support is also possible.
  • the protective member may have light diffusibility.
  • the protective member may be made of a material such as polycarbonate, polyester, acrylic, quartz glass or the like, and the protective member may be made to have light diffusivity by forming a micro uneven shape on the surface on the light incident side.
  • a light diffusing property may be provided by adding a light diffusing agent such as calcium carbonate or titanium oxide to a material such as polycarbonate, polyester, acrylic, quartz glass or the like constituting the protective member or silicon.
  • the protective member may be formed of a white-colored material such as polypropylene or polyvinyl chloride. When the protective member has light diffusivity, the amount of light irradiated to the subject can be made uniform.
  • FIG. 8 is a cross-sectional view of a probe of a second embodiment of the present invention.
  • the probe 10 is used by placing it in a sterile bag-like cover (sterile cover) 24.
  • sterile cover sterile cover
  • FIG. 8 shows an example in which the protective cover 14 is formed by the support 16 and the coupling member 20, the protective cover 14 is supported by the protective member 15 in the same manner as shown in FIG. It may be formed with the tool 16. Further, as in the case shown in FIG. 7, the coupling member 20 may double as a support.
  • the sterilization cover 24 is formed of, for example, polyethylene.
  • the sterile cover 24 is removable from the main body of the probe 10 integrally with the protective cover 14.
  • the outer side of the sterilization cover 24 is adhesively fixed, for example, to the surface (side surface) of the protective cover 14 (support 16) on the light emitting portion 13 side.
  • the inside of the sterilization cover 24 is adhered to the coupling member 20 which is also a protection member of the light emitting portion 13. In this case, the sterile cover 24 is held between the support 16 and the coupling member 20 in a sandwiching manner.
  • the support 16 is located outside the sterilization cover 24, and the coupling member 20 is located inside the sterilization cover 20.
  • a part of the protective cover 14 is not limited to being accommodated in the sterilization cover 24, and all of the protective cover 14 may be accommodated in the sterilization cover 24. Conversely, all of the protective covers 14 may be located outside of the sterile cover 24.
  • the protective cover 14 (support 16) is sterilized with the sterilization cover 24 in a state of being attached to the sterilization cover 24.
  • sterilization for example, electron beam sterilization, gamma ray sterilization, EOG (ethylene oxide gas) sterilization, etc. can be used.
  • the sterile cover 24 is attached to the probe 10 integrally with the protective cover 14, for example, by fitting the protective cover 14 (support 16) to the tip of the probe 10.
  • an acoustic binder such as ultrasonic jelly is applied between the sterilization cover 24 and the coupling member 20, an acoustic lens (not shown), etc., and then between the ultrasonic transducer 12 and the sterilization cover 24.
  • it is preferable not to create a portion that attenuates acoustic waves such as an air layer.
  • the sterilization cover 24 and the protection cover 14 are integrally configured, and the probe 10 is housed in the sterilization cover 24 and used.
  • the probe 10 is housed in the sterilization cover 24 and used.
  • the unsterilized probe 10 can be used in a clean area where sterility is required at the time of surgery.
  • the sterile cover 24 may be replaced with the protective cover 14 each time it is used, thereby enhancing patient safety.
  • the other effects are the same as in the first embodiment.
  • a probe and a protection cover of the present invention are not limited only to the above-mentioned embodiment, and various corrections and changes from the composition of the above-mentioned embodiment Those applied are also included in the scope of the present invention.
  • Probe 11 Electronic material 12: Ultrasonic transducer 13: Light guide plate 14: Protective cover 15: Protective member 16: Support 17: Hydrophilic film 18: Antireflective film 19: Hard film 20: Coupling member 21: Light Wiring 22: Electric wiring 24: Sterilization cover 31: Light source unit 32: Ultrasonic unit

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Acoustics & Sound (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

L'invention concerne une sonde et un couvercle protecteur de sonde servant à protéger une zone d'émission de rayonnement lumineux. Une plaque guide de lumière (13) émet de la lumière en direction d'un sujet à partir d'une surface d'émission de la lumière. Un vibreur ultrasonique (12) détecte les ondes photo-acoustiques produites à l'intérieur du sujet après émission de lumière en direction du sujet. Un couvercle protecteur (14) comprend, d'une part un élément protecteur laissant passer la lumière (15) et couvrant la surface d'émission de la lumière de la plaque guide de lumière (13), et d'autre part un entourage (16) destiné à supporter l'élément protecteur (15).
PCT/JP2013/066226 2012-06-20 2013-06-12 Sonde et couvercle protecteur pour celle-ci WO2013191060A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2012138349 2012-06-20
JP2012-138349 2012-06-20
JP2013097358A JP2014023914A (ja) 2012-06-20 2013-05-07 プローブ及びその保護カバー
JP2013-097358 2013-05-07

Publications (1)

Publication Number Publication Date
WO2013191060A1 true WO2013191060A1 (fr) 2013-12-27

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JP (1) JP2014023914A (fr)
WO (1) WO2013191060A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10820886B2 (en) 2016-12-14 2020-11-03 Samsung Medison Co., Ltd. Ultrasonic probe
US11607193B2 (en) 2018-01-15 2023-03-21 Samsung Medison Co., Ltd. Ultrasonic probe

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Publication number Priority date Publication date Assignee Title
JP6180843B2 (ja) * 2013-08-02 2017-08-16 富士フイルム株式会社 プローブ

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JP2010125260A (ja) * 2008-12-01 2010-06-10 Canon Inc 生体検査装置
JP2010179085A (ja) * 2008-07-11 2010-08-19 Canon Inc 生体情報取得装置
JP2011501150A (ja) * 2007-10-16 2011-01-06 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ コンパクトな照射スキームの生成及び一体化に対する装置、システム及び方法
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JPH10160711A (ja) * 1996-12-02 1998-06-19 Kao Corp 光音響信号測定装置
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US11607193B2 (en) 2018-01-15 2023-03-21 Samsung Medison Co., Ltd. Ultrasonic probe

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