WO2013018313A1 - Dispositif photoacoustique et sonde - Google Patents

Dispositif photoacoustique et sonde Download PDF

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Publication number
WO2013018313A1
WO2013018313A1 PCT/JP2012/004696 JP2012004696W WO2013018313A1 WO 2013018313 A1 WO2013018313 A1 WO 2013018313A1 JP 2012004696 W JP2012004696 W JP 2012004696W WO 2013018313 A1 WO2013018313 A1 WO 2013018313A1
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WO
WIPO (PCT)
Prior art keywords
light
photoacoustic
attachment
probe
acoustic wave
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Application number
PCT/JP2012/004696
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English (en)
Japanese (ja)
Inventor
辻田　和宏
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富士フイルム株式会社
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Filing date
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Publication of WO2013018313A1 publication Critical patent/WO2013018313A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/22—Details, e.g. general constructional or apparatus details
    • G01N29/24—Probes
    • G01N29/2418—Probes using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
    • A61B2562/164—Details of sensor housings or probes; Details of structural supports for sensors the sensor is mounted in or on a conformable substrate or carrier

Definitions

  • the present invention relates to a photoacoustic attachment, and more particularly to a photoacoustic attachment used by attaching to a probe.
  • the invention also relates to a probe comprising such an attachment.
  • Ultrasonography is known as a type of imaging that can noninvasively inspect the internal condition of a living body.
  • an ultrasonic probe capable of transmitting and receiving ultrasonic waves is used.
  • the ultrasonic waves travel inside the living body and are reflected at the tissue interface.
  • the internal appearance can be imaged by calculating the distance based on the time it takes for the ultrasound probe to receive the reflected sound and the reflected ultrasound to return to the ultrasound probe.
  • photoacoustic imaging which image-forms the inside of a biological body using a photoacoustic effect is known.
  • pulsed laser light such as a laser pulse is irradiated into a living body.
  • living tissue absorbs the energy of pulse laser light, and adiabatic expansion due to the energy generates an ultrasonic wave (photoacoustic signal).
  • photoacoustic signal is detected by an ultrasonic probe or the like, and a photoacoustic image is constructed based on the detection signal, whereby visualization in the living body based on the photoacoustic signal is possible.
  • the photoacoustic imaging apparatus is described, for example, in Patent Document 1.
  • An object of the present invention is, in view of the above, to provide a photoacoustic attachment used by attaching to an ultrasonic probe.
  • the present invention is a photoacoustic attachment attached to a probe having an acoustic wave detector element, which guides light to be irradiated to a subject, and the acoustic wave detection surface of the probe
  • a photoacoustic attachment having a light guide member for emitting light guided from an opposing light emitting surface toward a subject.
  • the light guiding member has a first portion for guiding light to the acoustic wave detecting surface side along the main body of the attached probe, and a light emitting surface, and the first portion And a second portion for emitting the light guided through the light from the light emitting surface toward the subject.
  • the first portion of the light guide member refracts the light guided along the probe body toward the acoustic wave detector element side as viewed from the side surface of the probe body to which the light is guided, and the second portion of the light guide member It is preferable to have the refracting surface which injects into the part of.
  • the second portion of the light guide member may include a resin lens having a refractive index different from that of the second partial body on the light emitting surface side.
  • the refractive index of the resin lens may be higher than the refractive index of the second partial body of the light guide member.
  • the resin lens refracts the incident light so that the emission angle of the light emitted from the light emission surface approaches a right angle.
  • the resin lens may have a refractive index gradient toward the center line of the light exit surface.
  • the second portion of the light guiding member reflects the light reflected by the first reflection film to the light emission surface side, the first reflection film reflecting light at the edge of the light emission surface toward the acoustic wave detection surface It can be set as the structure which has a 2nd reflective film to reflect.
  • the second portion of the light guide member may include a light diffusion acoustic member having acoustic wave transparency and light diffusivity, which is disposed to cover the acoustic wave detection surface.
  • the light diffusion acoustic member may be formed by mixing an inorganic pigment with an acoustic material having acoustic wave transparency.
  • the first portion of the light guide member may be inclined with respect to the main body of the attached probe so that the traveling direction of the light to be guided is inclined toward the acoustic wave detector element as viewed from the side surface of the probe main body .
  • the second portion of the light guide member may include a transparent urethane gel.
  • the second portion of the light guide member may further include a support member that is light transmissive and that encloses and supports the transparent urethane rubber.
  • the exterior which supports a light guide member may be provided, and the surface by the side of the light guide member of the exterior may be formed in white.
  • the present invention also relates to an acoustic wave detector element disposed in a probe body and a photoacoustic attachment attached to the probe body, which guides light to be irradiated to a subject and detects the acoustic wave.
  • a probe comprising: a photoacoustic attachment having a light guide member for emitting light guided from the light emitting surface facing the acoustic wave detecting surface provided with the light emitting element toward the object from the light emitting surface.
  • the photoacoustic attachment has a first portion for guiding light to the acoustic wave detection surface side along the probe main body, and a light emitting surface, and emits the light guided through the first portion.
  • a configuration including a second portion that emits from the surface toward the object can be employed.
  • the second portion of the light guide member has a first reflection film that reflects light at the edge of the light emission surface toward the acoustic wave detection surface, and is provided on the surface of the acoustic wave detector element on the acoustic wave detection surface side It is possible to form a second reflection film that reflects the light reflected by the first reflection film to the light emitting surface side.
  • the photoacoustic attachment guides the light to be irradiated to the subject, and guides the light guided toward the subject from the light irradiation surface facing the ultrasonic detection surface of the attached probe. It has a light member.
  • a photoacoustic attachment By using such a photoacoustic attachment, light irradiation can be performed on the subject from the photoacoustic attachment attached to the probe. Since the photoacoustic attachment moves with the attached probe, the user can move the probe to a desired position of the subject and irradiate light at that position, which is excellent in operability. Further, since the photoacoustic attachment and the probe are integrated, the position setting of the illumination system is stable, and light can be emitted at a desired incident angle designed for the object.
  • the graph which shows the relationship between the particle size of an inorganic pigment, and scattering efficiency.
  • Sectional drawing of the attachment using transparent urethane rubber Sectional drawing which shows the attachment which the waveguide inclines. Sectional drawing of the attachment including an exterior. Sectional drawing which shows the example by which an attachment is integrated inside a probe case.
  • the side view of the attachment for photoacoustics attached to the ultrasound probe for urology The front view of the attachment for photoacoustics attached to the ultrasonic probe for urology.
  • FIG. 1 shows the entire configuration of a photoacoustic image generating apparatus including a photoacoustic attachment according to a first embodiment of the present invention.
  • the photoacoustic image generation apparatus 10 includes an ultrasonic probe 11, an ultrasonic unit 12, a laser unit 13, and an attachment 14.
  • the ultrasound probe 11 is connected to the ultrasound unit 12 via a cable 15 or the like.
  • the attachment 14 is connected to the laser unit 13 via a light guide such as an optical fiber 16.
  • the laser unit 13 is a light source unit that emits a laser beam to be irradiated to a subject.
  • the wavelength of the laser beam emitted by the laser unit 13 is appropriately set according to the light absorber to be observed and the like.
  • the attachment 14 is a photoacoustic attachment attached to the ultrasonic probe 11.
  • the attachment 14 includes a light guide member 41 for guiding the laser light to be irradiated to the subject.
  • the laser beam emitted from the laser unit 13 is incident on the attachment 14 through the optical fiber 16 and the like, and is irradiated onto the subject from the light guide member 41.
  • the light irradiated to the subject is not limited to the laser light, and light other than the laser light may be irradiated to the subject.
  • the ultrasonic probe 11 has an acoustic wave detector (ultrasonic wave detector) 22 for detecting an acoustic wave (typically, an ultrasonic wave) from the inside of the subject in a probe case 21.
  • the ultrasound detector 22 includes an ultrasound detector element.
  • the ultrasonic detector 22 has a plurality of ultrasonic transducers (ultrasound detector elements) which are one-dimensionally arranged along the longitudinal direction of the probe case 21.
  • the ultrasound detector 22 detects the ultrasound (photoacoustic signal) generated in the subject by irradiating the inside of the subject with light.
  • the ultrasound unit 12 receives a photoacoustic signal from the ultrasound probe 11 via the cable 15 and generates a photoacoustic image based on the received photoacoustic signal.
  • the light guide member 41 includes a waveguide (light guide path) 42 and a light guide plate 43.
  • the waveguide 42 corresponds to a first portion for guiding light to the ultrasonic detection surface side along the main body of the probe to which the attachment 14 is attached.
  • the light guide plate 43 corresponds to a second portion that emits the light guided through the first portion from the light emission surface toward the subject.
  • the waveguide 42 is connected to the optical fiber 16 via, for example, a connector.
  • the waveguide 42 guides the laser light incident from the laser unit 13 to the ultrasonic detection surface side of the ultrasonic detector 22 along the probe body of the ultrasonic probe 11.
  • the light guide plate 43 has a light emitting surface, and emits the laser light guided through the waveguide 42 in the direction of the subject.
  • FIGS. 2A and 2B show the attachment 14 attached to the ultrasonic probe 11.
  • FIG. 2A is a front view of the attachment 14, and
  • FIG. 2B is a side view of the attachment 14.
  • the ultrasound probe 11 is, for example, an ultrasound probe of a type that a user holds by hand and uses.
  • the waveguide 42 portion of the light guide member 41 and the light guide plate 43 portion are integrally formed, and the light guide member 41 constitutes an attachment body.
  • the light guide member 41 which is the attachment main body, is detachably attached to the ultrasonic probe 11 by, for example, a tab 44 or the like.
  • the light guide member 41 and the ultrasonic probe 11 may be integral and indivisible.
  • the waveguide 42 is connected, for example, to the light emitting end of the optical fiber 16 via a connector or the like. Although only one optical fiber is drawn in FIG. 2A, a plurality of optical fibers may be arranged in the longitudinal direction of the ultrasonic probe 11, and laser light may be incident from the plurality of optical fibers. Further, in FIG. 2B, the two waveguides 42 are provided to face each other across the ultrasonic probe 11, but a configuration in which the waveguides 42 are provided on only one side is also possible.
  • the waveguide 42 is formed in, for example, a tapered shape as viewed from the front, and the laser beam may be spread in the longitudinal direction of the ultrasonic probe 11 while the laser beam travels to the surface side where the ultrasonic transducers are arranged. Good.
  • the light guide plate 43 has a light emission surface 51 at a position facing the ultrasonic detection surface 50 in which the ultrasonic transducers of the ultrasonic probe 11 are arranged.
  • the light emission surface 51 faces the ultrasonic detection surface 50 at a distance d corresponding to the thickness of the light guide plate 43 so as to spatially overlap with the ultrasonic detection surface 50, for example.
  • the light guide plate 43 receives the laser beam from the waveguide 42 and emits the laser beam from the light emitting surface 51 directly below the ultrasonic detection surface 50 toward the subject.
  • a light guide plate 43 exists between the ultrasonic detection surface 50 and the subject, and the ultrasonic detector 22 detects a photoacoustic signal generated in the subject via the light guide plate 43.
  • the waveguide 42 and the light guide plate 43 for example, silicon resin, low density polyethylene, epoxy resin, acrylic, PMMA (Poly Methyl Methacrylate), PC (polycarbonate), etc. can be used. It is preferable that the light guide plate 43 be formed of a material that transmits light in a wavelength range including the wavelength of the light irradiated to the subject and that the attenuation of ultrasonic waves is small.
  • FIG. 3 shows a cross section near the center of the attachment 14.
  • the waveguide 42 is directed toward the ultrasonic detector element as viewed from the side surface of the probe body to which the light is guided (for example, the direction in which the ultrasonic transducers are one-dimensionally arrayed) the light guided along the probe body It may have a refracting surface 45 to refract.
  • the refracting surface 45 is formed at an inclined angle with respect to the side surface of the probe case 21.
  • the refracting surface 45 is formed by the interface of two members having different refractive indices.
  • the refractive index of the light incident side (optical fiber 16 side) of the waveguide 42 is made higher than the refractive index of the light outgoing side (light guide plate 43 side), and the interface is on the side surface of the probe case 21 as shown in FIG.
  • the ultrasonic detector element side the inner side of the ultrasonic detection surface 50.
  • FIG. 4 shows an operation procedure of photoacoustic image generation.
  • the attachment 14 is attached to the ultrasonic probe 11 prior to the laser beam irradiation to the subject (step S1).
  • a plurality of attachments having different thicknesses d of the light guide plate 43 (FIG. 2B), that is, different distances between the ultrasonic detection surface 50 and the light emission surface 51, are prepared. You may choose.
  • the light guide member 41 of the attachment 14 and the optical fiber 16 are connected by a connector or the like so that the laser light can be incident on the attachment 14.
  • the laser beam is emitted from the laser unit 13 in a state where the ultrasonic probe 11 to which the attachment 14 is attached is brought into contact with a desired position of the subject, and the attachment 14 irradiates the subject with the laser beam (step S2) .
  • the light absorber in the subject absorbs the energy of the irradiated laser light to generate a photoacoustic signal.
  • the ultrasonic detector 22 of the ultrasonic probe 11 detects the photoacoustic signal from the subject (step S3).
  • the ultrasound unit 12 receives the photoacoustic signal detected via the cable 15, and generates a photoacoustic image based on the received photoacoustic signal (step S4).
  • the ultrasound unit 12 displays, for example, the generated photoacoustic image on a display monitor.
  • the attachment 14 attached to the ultrasonic probe 11 is configured by the light guide member 41, and the attachment 14 integrated with the waveguide can emit the laser light to the subject.
  • the attachment 14 attached thereto is also moved together, so the user moves the ultrasonic probe 11 to a desired position on the subject and the laser light is moved to that position. Can be irradiated and it is excellent in operability.
  • the ultrasonic probe 11 and the attachment 14 are integrated, the position setting of the illumination system is stable. Therefore, the laser light can be irradiated from the attachment 14 at the designed incident angle to the subject.
  • the waveguide 42 is provided with the refracting surface 45.
  • the refracting surface 45 provides the refracting surface 45 by refracting the laser light incident from the optical fiber 16 side in the cross section shown in FIG. 3 toward the ultrasonic detector element as viewed from the side of the probe main body. The amount of light near the center can be increased as compared to the case where there is no light.
  • the laser beam irradiated to the object from near the center of the thickness direction of the ultrasonic probe 11 (for example, the direction substantially orthogonal to the longitudinal direction in which a plurality of ultrasonic detector elements are one-dimensionally arrayed)
  • the amount of light can be secured, and the laser light can be irradiated with a sufficient amount of light immediately below the ultrasonic detection surface 50.
  • FIG. 5 shows a photoacoustic attachment according to a second embodiment of the present invention.
  • the photoacoustic attachment 14a of this embodiment is different from the photoacoustic attachment 14 of the first embodiment shown in FIG. 3 in that the light guide plate 43a includes a resin lens 46 having a refractive index different from that of the light guide plate main body.
  • the other points may be the same as in the first embodiment.
  • the resin lens 46 is disposed on the light emitting surface 51 side of the light guide plate 43a.
  • the resin lens 46 has a center in a direction orthogonal to the longitudinal direction of the ultrasonic detection surface 50 (a direction substantially orthogonal to the direction in which the plurality of Are arranged symmetrically with respect to the center).
  • the refractive index of the resin lens 46 is higher than the refractive index of the light guide plate 43a main body. The resin lens 46 refracts the incident light so that the emission angle of the light emitted from the light emission surface 51 of the light guide plate 43a approaches a right angle.
  • the laser light emitted from the laser unit 13 passes through the optical fiber 16 and enters the waveguide.
  • the light guided through the waveguide 42 travels toward the light guide plate 43 a and further travels toward the light emission surface 51.
  • the laser light traveling toward the light emission surface 51 enters the resin lens 46, the laser light is refracted by the difference in refractive index between the resin lens 46 and the light guide plate main body, and the light emission becomes an angle closer to a right angle
  • the light is emitted from the surface 51 in the direction of the subject.
  • the resin lens 46 may have a refractive index gradient toward the center line of the light emission surface 51.
  • FIG. 6 shows an example of a resin lens having a refractive index gradient.
  • the resin lens 46 is formed of five layers of resin lens layers 46-1, 46-2, 46-3, 46-4, and 46-5 from the side of the interface with the light guide plate 43a. Assuming that the refractive indices of the resin lens layers 46-1 to 46-5 are n 1 to n 5 , the refractive indices of the respective layers satisfy the relationship of n 5 > n 4 > n 3 > n 2 > n 1 .
  • the resin lens 46 is provided on the light emission surface 51 side of the light guide plate 43a. By refracting the incident light, the resin lens 46 can irradiate the laser light at an angle closer to a right angle with respect to the subject.
  • the other effects are the same as in the first embodiment.
  • FIG. 7 shows a photoacoustic attachment according to a third embodiment of the present invention.
  • the photoacoustic attachment 14b of the present embodiment differs from the photoacoustic attachment 14 of the first embodiment shown in FIG. 3 in that the photoacoustic attachment 14b includes light reflecting films 47 and 48 that reflect light incident on the light guide plate 43b.
  • the other points may be the same as in the first embodiment.
  • the ultrasonic detection surface 50 of the ultrasonic probe 11 and the light emitting surface 51 of the attachment 14b face each other at an interval corresponding to the thickness of the light guide plate 43b.
  • the first reflection film 47 is formed on the light emitting surface 51 side of the light guide plate 43b.
  • the first reflection film 47 is formed at a predetermined angle with respect to the light emission surface 51 directly below the light traveling direction of the waveguide 42, and around the edge of the light emission surface 51, the light emission surface 51 is directed The light which has traveled in the direction of the light is reflected in the direction of the ultrasonic detection surface 50.
  • the second reflection film 48 is formed on the ultrasonic detection surface 50 side of the light guide plate 43 b.
  • the second reflection film 48 is formed, for example, in parallel with the ultrasonic detection surface 50 so as to cover a plurality of ultrasonic detector elements arranged in a one-dimensional manner.
  • the second reflection film 48 reflects the light reflected by the first reflection film 47 and traveling toward the ultrasonic detection surface 50 in the direction of the light emission surface 51.
  • the second reflection film 48 does not necessarily have to be provided on the light guide plate 43 b, and for example, the second reflection film 48 can be formed on the ultrasonic probe 11.
  • the surface on the ultrasonic detection surface 50 side of a plurality of ultrasonic detector elements arranged in one dimension may be coated with a metal thin film, and this may be used as the second reflection film 48.
  • the laser light emitted from the laser unit 13 passes through the optical fiber 16 and enters the waveguide.
  • the light guided through the waveguide 42 travels toward the light guide plate 43 b and travels further toward the light emission surface 51.
  • the laser light traveling straight from the waveguide 42 toward the light emission surface 51 is reflected by the first reflection film 47 and travels toward the ultrasonic detection surface 50, and is reflected again by the second reflection film 48. Head toward the light exit surface 51.
  • the laser beam reflected by the second reflection film 48 is emitted from the opening of the first reflection film 47 in the direction of the subject.
  • the light traveling toward the edge of the light emission surface 51 is reflected by the first reflection film 47 toward the ultrasonic detection surface 50, and the reflected light is reflected again by the second reflection film 48, Laser light is emitted from the emission surface 51 to the subject.
  • the first reflection film 47 and the second reflection film 48 By using the first reflection film 47 and the second reflection film 48, light can be collected near the center in the direction orthogonal to the longitudinal direction of the ultrasonic detection surface 50. Further, by appropriately setting the relative angle between the first reflection film 47 and the second reflection film 48, the laser light to be irradiated to the subject is closer to a right angle from the light emission surface 51. It can be emitted at an angle.
  • the other effects are the same as in the first embodiment.
  • FIGS. 8A and 8B show the attachment of the fourth embodiment of the present invention attached to the ultrasonic probe.
  • FIG. 8A is a front view of the attachment
  • FIG. 8B is a side view of the attachment.
  • the attachment 14 c of the present embodiment is shown in FIGS. 2A and 2B in that the attachment 14 c further includes a light diffusion acoustic member 60 disposed so as to cover the ultrasonic detection surface 50 and having acoustic wave transparency and light diffusion. It differs from the attachment 14 of the first embodiment. 8A and 8B, the tab 44 is omitted.
  • the light diffusion acoustic member 60 is formed, for example, by mixing an inorganic pigment with an acoustic material having acoustic wave transparency.
  • an acoustic material rubber materials such as silicone rubber and polyurethane can be used.
  • the inorganic material at least one oxide particle of titanium oxide, zirconium oxide, iron oxide, and cerium oxide can be used.
  • Preferred optical characteristics of the light diffusion acoustic member 60 will be described. For example, when the average diffuse reflectance in the wavelength range of light (measurement light) irradiated to the object of the light diffusion acoustic member 60 is less than 85%, the light reflected by the object to be measured is the light diffusion acoustic member 60 It passes through and enters the ultrasonic detector 22, and an artifact (a virtual image or a false image) is generated due to the vibration generated by the absorption of light by the ultrasonic detector 22.
  • an artifact a virtual image or a false image
  • the light diffusion acoustic member 60 have an optical characteristic that the average diffuse reflectance in the wavelength range of the measurement light is 85% or more and the average absorptance is 10% or less.
  • FIG. 9 shows the relationship between the particle size of the inorganic pigment and the scattering efficiency.
  • the graph shown in FIG. 9 is a plot of scattering efficiency values calculated assuming Mie scattering at 756 nm light.
  • Plot A is data for a sample prepared by mixing titanium oxide (refractive index: 2.6) with silicone rubber (refractive index: 1.41), and plot B shows zirconium oxide (refractive index: 2. with silicone rubber). It is data about the sample which mixed 4).
  • Plot C is data of a sample in which polystyrene (refractive index: 1.6) is mixed with silicone rubber.
  • the particle size of the inorganic pigment when the particle size of the inorganic pigment is in the range of 0.05 to 0.35 ⁇ m, high diffuse reflectance can be obtained even if the concentration (particle concentration) of oxide particles relative to the acoustic material is low. It can be seen that Therefore, the particle size of the inorganic pigment mixed in the acoustic member is preferably 0.05 to 0.35 ⁇ m. Furthermore, in consideration of the fact that the particles of the inorganic pigment do not increase the sound attenuation factor, the particle size of the inorganic pigment is preferably 0.08 to 0.2 ⁇ m.
  • particle size means the average value of the particle diameter of the material type. The size of the particles can be measured, for example, by dynamic light scattering, laser diffraction, and imaging with a scanning electron microscope (SEM).
  • the thickness (thickness of the thickest portion) of the light diffusing acoustic member 60 is preferably 0.5 to 2 mm. When the thickness is smaller than 0.5 mm, it is difficult to obtain the diffuse reflectance in the wavelength range of the measurement light at a predetermined concentration. Moreover, when thickness is thicker than 2 mm, the absorption in the wavelength range of the measurement light by the material of the said member will increase.
  • the addition amount of the inorganic pigment is appropriately adjusted within the range in which the occurrence of the artifact becomes an electrical noise level and does not cause an image problem.
  • the addition amount of the inorganic pigment is preferably 2 to 65 wt%. When the addition amount of the inorganic pigment is less than 2 wt%, the average diffuse reflectance in the wavelength region of the measurement light does not reach 85%, and when the addition amount is more than 65 wt%, the average in the wavelength region of the measurement light The effect of increasing the diffuse reflectance is saturated.
  • the scattering ability (diffuse reflectance) is saturated.
  • the scattering ability is saturated when, for example, the volume fraction of inorganic pigment in a mixture of silicone rubber and inorganic pigment is 0.155. . Therefore, the addition amount of the inorganic pigment is appropriately set in the range where the volume fraction of the inorganic pigment in the material constituting the light diffusion acoustic member 60 is lower than 0.155. The same applies to iron oxide and cerium oxide not shown in the graph of FIG.
  • the attachment 14 c includes a light diffusion acoustic member 60 that covers the ultrasonic detection surface 50 of the ultrasonic detector 22.
  • the light diffusion acoustic member 60 can suppress the incidence of light on the ultrasonic detector 22, thereby suppressing an artifact caused by the incidence of light on the ultrasonic detector 22.
  • the other effects are the same as in the first embodiment.
  • the second portion of the light guide member that emits the light guided toward the subject from the light emission surface is the light guide plate 43, but the second embodiment The portion is not limited to the light guide plate 43.
  • the second part may be light transmissive and ultrasonic transparent, and a transparent urethane gel such as Sonagel (trade name) may be used for the second part.
  • the second part may have a light transmitting property and a bag (supporting member) surrounding and supporting the transparent urethane rubber.
  • FIG. 10 shows a cross section of an attachment using a transparent urethane rubber.
  • the cross section shown in FIG. 10 corresponds to the cross section of the side surface shown in FIG. 8B.
  • the second portion 43 d of the light guide member includes a bag 61 and a transparent urethane gel 62.
  • the transparent urethane gel 62 is formed of a gel-like material that transmits light and acoustic waves.
  • the bag 61 has the property of transmitting light and acoustic waves, and wraps and holds the transparent urethane gel 62. By wrapping the transparent urethane gel 62 in the bag 61, the shape of the transparent urethane gel 62 can be easily maintained. In addition, the strength is also improved.
  • the light diffusion acoustic member 60 is disposed at a position covering the ultrasonic wave detector 22 (FIG. 3) when the attachment 14d is attached to the probe, but the light diffusion acoustic member 60 may not be provided. Good.
  • the cross-sectional shape of the waveguide 42 is illustrated as being rectangular, but the cross-sectional shape of the waveguide 42 is arbitrary.
  • the cross-sectional shape of the waveguide 42 is a cross-sectional shape formed of a straight line, a spherical surface, or any other shape, the distribution of the light intensity of the laser light emitted from the light emission surface of the light guide plate 43 becomes as uniform as possible. Good.
  • the waveguide 42 does not have to be parallel to the side surface of the probe body, and the waveguide 42 may be inclined with respect to the side surface of the probe body.
  • FIG. 11 shows an attachment where the waveguide is tilted.
  • the waveguide 42 (the first portion of the light guide member) is attached such that the traveling direction of the light to be guided is inclined toward the detector element side of the ultrasonic detector 22 when viewed from the side of the probe main body Is tilted with respect to the main body of the probe.
  • the exterior which covers the light guide member 41 (FIG. 1) containing the waveguide 42 and the light guide plate 43 is not shown for simplification of description,
  • it is at least partially covered by an exterior formed of resin.
  • FIG. 12 shows a cross section of the attachment including the exterior.
  • the sheath 63 is made of, for example, an ABS resin (Acrylonitrile Butadiene Styrene) resin, and a coating containing an inorganic pigment is applied to the surface on the waveguide 42 and the light guide plate 43 side (inner side).
  • the inorganic pigment at least one oxide particle of titanium oxide, zirconium oxide, iron oxide, and cerium oxide can be used.
  • the color of the inside of the exterior 63 becomes white by the coating film of these inorganic pigments.
  • the white does not have to be completely white, but may be white mixed with some color such as yellow or brown.
  • FIG. 13 shows an example in which the attachment 14 is incorporated inside the probe case 21.
  • the probe case 21 has a space for accommodating the attachment 14.
  • the attachment 14 can be attached to the ultrasonic probe 11 by inserting the waveguide portion of the attachment 14 into the space.
  • FIGS. 2A and 2B a hand-held ultrasonic probe is assumed as the ultrasonic probe 11, but the ultrasonic probe to which the photoacoustic attachment is attached is not limited to the hand-held type.
  • 14A and 14B show a state in which the photoacoustic attachment is attached to the intraoperative ultrasonic probe.
  • FIG. 14A is a side view
  • FIG. 14B is a front view.
  • a photoacoustic attachment 14 is attached to the intraoperative ultrasonic probe 11a.
  • the laser light incident from the optical fiber 16 passes through the waveguide 42 and the light guide plate 43, and is directly below the surface (ultrasonic detection surface) on which the detector elements of the ultrasonic detector 22 are arrayed. It is irradiated.
  • FIG. 15A and FIG. 15B have shown the state in which the attachment for photoacoustics was attached to the ultrasound probe for urinary tracts.
  • FIG. 15A is a side view
  • FIG. 15B is a front view.
  • a photoacoustic attachment 14 is attached to the urinary ultrasound probe 11b.
  • the waveguide 42 is inserted in the probe main body, and is held by a holding member (outer case) 49.
  • the laser light incident from the optical fiber 16 passes through the waveguide 42 and the light guide plate 43, and is directly below the surface (ultrasonic detection surface) on which the detector elements of the ultrasonic detector 22 are arrayed. It is irradiated.
  • the attachment for photoacoustics and the ultrasonic probe of the present invention are not limited only to the above-mentioned embodiment, and variously from composition of the above-mentioned embodiment Those modified and changed are also included in the scope of the present invention.

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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Acoustics & Sound (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)

Abstract

[Problème] Décrire un dispositif photoacoustique destiné à être utilisé en étant attaché à une sonde. [Solution] La présente invention concerne une sonde ultrasonore (11) qui a un détecteur ultrasonore (22) qui comprend un ou plusieurs éléments détecteurs. Un dispositif (14) est un dispositif photoacoustique destiné à être fixé à la sonde ultrasonore (11). Le dispositif (14) a un composant de guide optique (41) qui comprend, par exemple, un guide d'onde (42) et une plaque de guide optique (43). Le composant de guide d'onde (41) guide une lumière destinée à être irradiée vers un sujet à inspecter, et irradie la lumière guidée vers le sujet depuis une surface de sortie de lumière de la sonde ultrasonore (11), ladite surface de sortie de lumière faisant face à la surface de détection ultrasonore de la sonde ultrasonore.
PCT/JP2012/004696 2011-07-29 2012-07-24 Dispositif photoacoustique et sonde WO2013018313A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2011-166335 2011-07-29
JP2011166335 2011-07-29
JP2012159395A JP5795557B2 (ja) 2011-07-29 2012-07-18 光音響用アタッチメント及びプローブ
JP2012-159395 2012-07-18

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WO2013018313A1 true WO2013018313A1 (fr) 2013-02-07

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013121743A1 (fr) * 2012-02-13 2013-08-22 富士フイルム株式会社 Sonde de détection d'onde acoustique et dispositif de mesure photoacoustique comportant celle-ci
WO2014156808A1 (fr) * 2013-03-26 2014-10-02 富士フイルム株式会社 Sonde

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Publication number Priority date Publication date Assignee Title
US20150265155A1 (en) * 2014-02-27 2015-09-24 Seno Medical Instruments, Inc. Probe having light delivery through combined optically diffusing and acoustically propagating element
USD756818S1 (en) 2014-07-10 2016-05-24 Fujifilm Corporation Probe for photoacoustic measurement device
JP6152079B2 (ja) 2014-08-29 2017-06-21 プレキシオン株式会社 光音響画像化装置用プローブ

Citations (4)

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JPH10160711A (ja) * 1996-12-02 1998-06-19 Kao Corp 光音響信号測定装置
JP2005021380A (ja) * 2003-07-02 2005-01-27 Toshiba Corp 生体情報映像装置
JP2008049063A (ja) * 2006-08-28 2008-03-06 Osaka Prefecture Univ 光トモグラフィ装置用プローブ
WO2012102036A1 (fr) * 2011-01-28 2012-08-02 富士フイルム株式会社 Sonde ultrasonore

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10160711A (ja) * 1996-12-02 1998-06-19 Kao Corp 光音響信号測定装置
JP2005021380A (ja) * 2003-07-02 2005-01-27 Toshiba Corp 生体情報映像装置
JP2008049063A (ja) * 2006-08-28 2008-03-06 Osaka Prefecture Univ 光トモグラフィ装置用プローブ
WO2012102036A1 (fr) * 2011-01-28 2012-08-02 富士フイルム株式会社 Sonde ultrasonore

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013121743A1 (fr) * 2012-02-13 2013-08-22 富士フイルム株式会社 Sonde de détection d'onde acoustique et dispositif de mesure photoacoustique comportant celle-ci
US9791417B2 (en) 2012-02-13 2017-10-17 Fujifilm Corporation Acoustic wave detection probe and photoacoustic measurement apparatus provided with the same
WO2014156808A1 (fr) * 2013-03-26 2014-10-02 富士フイルム株式会社 Sonde
JP2014207975A (ja) * 2013-03-26 2014-11-06 富士フイルム株式会社 プローブ
US11141068B2 (en) 2013-03-26 2021-10-12 Fujifilm Corporation Replacement method for a damaged part of a light emitter of a probe

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JP5795557B2 (ja) 2015-10-14

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