WO2013185757A1 - Vorrichtung zur optischen darstellung des augeninnendrucks sowie verfahren dazu - Google Patents

Vorrichtung zur optischen darstellung des augeninnendrucks sowie verfahren dazu Download PDF

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Publication number
WO2013185757A1
WO2013185757A1 PCT/DE2013/100214 DE2013100214W WO2013185757A1 WO 2013185757 A1 WO2013185757 A1 WO 2013185757A1 DE 2013100214 W DE2013100214 W DE 2013100214W WO 2013185757 A1 WO2013185757 A1 WO 2013185757A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
intraocular pressure
reflected
eye
photonic crystal
Prior art date
Application number
PCT/DE2013/100214
Other languages
German (de)
English (en)
French (fr)
Inventor
Yousef NAZINZADEH
Martina Gerken
Torben KARROCK
Johann Roider
Original Assignee
Universitätsklinikum Schleswig-Holstein
Christian-Albrechts-Universität Zu Kiel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitätsklinikum Schleswig-Holstein, Christian-Albrechts-Universität Zu Kiel filed Critical Universitätsklinikum Schleswig-Holstein
Priority to US14/406,827 priority Critical patent/US9730788B2/en
Priority to IN2968KON2014 priority patent/IN2014KN02968A/en
Priority to EP13741662.4A priority patent/EP2861126B1/de
Publication of WO2013185757A1 publication Critical patent/WO2013185757A1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/16Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1659Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having variable absorption coefficient for electromagnetic radiation, e.g. photochromic lenses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2002/16965Lens includes ultraviolet absorber
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2002/16965Lens includes ultraviolet absorber
    • A61F2002/1699Additional features not otherwise provided for

Definitions

  • the invention relates to a device according to the preamble of the main claim for optical representation of the intraocular pressure.
  • Increased intraocular pressure is one of the major causes of glaucoma in pathogenesis, which can cause vision or visual field loss. Glaucoma blindness is estimated to be around 50,000 a year. Timely measurement of intraocular pressure and appropriate drug treatment and timely surgical therapy could, however, prevent disease.
  • the patient with the help of a small, advantageously automated readout device can determine his intraocular pressure independently and without contact. It is therefore an object of the invention to provide an externally readable intraocular pressure sensor for reading by either the patient himself or with higher accuracy by pharmacies or medical staff.
  • a purely visual measurement is performed using a special magnifying glass, in which the patient determines the color wheel size of the sensor.
  • the method according to the invention for the optical representation of the intraocular pressure will work with a device which is preferably implanted on an intraocular lens in the eye and which has a membrane which bulges out when the intraocular pressure changes and a pressure surface.
  • a device which is preferably implanted on an intraocular lens in the eye and which has a membrane which bulges out when the intraocular pressure changes and a pressure surface.
  • the intraocular pressure is increased, in the region of contact of the membrane with the surface, e.g. change the polarization for a spectral range of incident and reflected light by a reversible chemical reaction or by other optical effects.
  • a readout device for optically reproducing a two-dimensional image of the polarization-modified light reflected by the photonic crystal which has a polarization filter for the light reflected and that reflected by the photonic crystal, can be used for purely visual measurement with daylight and, for example, from a mirror exist, with which the patient directs light into the eye.
  • a circular polarizing filter would then be provided which polarizes the incident and also the backscattered light. The observation of the eye would be done by the patient in the mirror, whereby he would recognize no or a small discolored area with normal intraocular pressure.
  • this surface may also be formed curved. It is also conceivable to impress a plurality of contact points or rings on this surface in order to give the representation a gradual course.
  • a reference scale provided with defined known geometrical dimensions will also be possible on the pressure surface, or an already existing bar code or ID number can be moved so close to the area of the contact between membrane and surface that, in particular, in the case of a camera and software Evaluation is the area of the reference scale in the image.
  • an automated readout device it is proposed to work with defined illumination and to provide a camera as part of the readout device, whereby a storable image is generated.
  • two longitudinally polarizing filters can be provided, wherein that in the Einstrahlstrahlengang and that for the reflected light are crossed by 90 °, for representing the area of the surface contact as a difference image.
  • the captured camera image can then be processed with computer means based on a previously known reference variable contained in the image for the determination of a numerical value of the intraocular pressure from the size of the detected contact surface.
  • the invention proposes that the nanostructured surface is located inside a reference pressure chamber, which is closed by a membrane, in the intraocular lens, whose internal pressure is dimensioned so that no or only minimal contact between membrane and surface arises at normal intraocular pressure.
  • Fig. 1 is a schematic representation of an artificial lens with an integrated intraocular pressure sensor at the edge and
  • FIG. 2 shows a measuring setup for reading the pressure value in the form of a larger or smaller visible area depending on the pressure.
  • the intraocular pressure sensor consists of a movable membrane, a periodic nanostructured surface (photonic crystal) and a reference pressure chamber.
  • the reference pressure is preset so that at the lowest intraocular pressure value the membrane just touches the photonic crystal surface. It is conceivable to provide a set of artificial lenses each provided with a different reference pressure for various possible intraocular pressures, so that a lens suitable for the respective patient can be used during the implantation.
  • the membrane With an increase in pressure in the eye, the membrane is then pressed in a larger area to the photonic crystal.
  • the reflection spectrum differs locally depending on whether the membrane is pressed against the photonic crystal or not, since the pressed membrane leads to a refractive index change on the surface of the photonic crystal.
  • Fig. 2 shows a measurement setup for reading the pressure value in the form of a larger or smaller depending on the pressure visible surface.
PCT/DE2013/100214 2012-06-13 2013-06-12 Vorrichtung zur optischen darstellung des augeninnendrucks sowie verfahren dazu WO2013185757A1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US14/406,827 US9730788B2 (en) 2012-06-13 2013-06-12 Device for optically representing intraocular pressure, and a method for same
IN2968KON2014 IN2014KN02968A (enCached4) 2012-06-13 2013-06-12
EP13741662.4A EP2861126B1 (de) 2012-06-13 2013-06-12 Vorrichtung zur optischen darstellung des augeninnendrucks

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012105129.1 2012-06-13
DE201210105129 DE102012105129A1 (de) 2012-06-13 2012-06-13 Vorrichtung zur optischen Darstellung des Augeninnendrucks sowie Verfahren dazu

Publications (1)

Publication Number Publication Date
WO2013185757A1 true WO2013185757A1 (de) 2013-12-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2013/100214 WO2013185757A1 (de) 2012-06-13 2013-06-12 Vorrichtung zur optischen darstellung des augeninnendrucks sowie verfahren dazu

Country Status (5)

Country Link
US (1) US9730788B2 (enCached4)
EP (1) EP2861126B1 (enCached4)
DE (1) DE102012105129A1 (enCached4)
IN (1) IN2014KN02968A (enCached4)
WO (1) WO2013185757A1 (enCached4)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016064867A3 (en) * 2014-10-20 2016-08-25 The Regents Of The University Of California Optical intraocular sensor and sensing method

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013090886A1 (en) 2011-12-16 2013-06-20 California Institute Of Technology System and method for sensing intraocular pressure
WO2017095825A1 (en) * 2015-11-30 2017-06-08 California Institute Of Technology System and method for measuring intraocular pressure
WO2018035091A1 (en) 2016-08-15 2018-02-22 University Of Florida Research Foundation, Inc. Methods and compositions relating to tunable nanoporous coatings
WO2018090330A1 (zh) * 2016-11-18 2018-05-24 深圳先进技术研究院 一种植入式器件及其制备方法
CN106580247A (zh) * 2016-11-18 2017-04-26 中国科学院深圳先进技术研究院 一种植入式器件及其制备方法
US11467094B2 (en) 2017-05-17 2022-10-11 University Of Florida Research Foundation, Inc. Methods and sensors for detection
US11480527B2 (en) 2017-12-20 2022-10-25 University Of Florida Research Foundation, Inc. Methods and sensors for detection
WO2019126171A1 (en) 2017-12-21 2019-06-27 University Of Florida Research Foundation Substrates having a broadband antireflection layer and methods of forming a broadband antireflection layer
WO2019246370A1 (en) * 2018-06-20 2019-12-26 University Of Florida Research Foundation Intraocular pressure sensing material, devices, and uses thereof
CN113252229B (zh) * 2021-07-15 2021-09-14 成都辰迈科技有限公司 一种非静止流体压力测量装置及其使用方法

Citations (6)

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WO2004062480A2 (en) * 2003-01-09 2004-07-29 The Regents Of The University Of California Implantable devices and methods for measuring intraocular, subconjunctival or subdermal pressure and/or analyte concentration
DE102005041271A1 (de) * 2005-08-31 2007-03-01 Carl Zeiss Meditec Ag Verfahren zur Ermittlung einer Konzentration wenigstens eines Stoffes im Kammerwasser und/oder im Gewebe des Auges und Implantat zur Durchführung des Verfahrens
WO2007035356A2 (en) * 2005-09-16 2007-03-29 Bg Implant, Inc. Glaucoma treatment devices and methods
US20090299216A1 (en) * 2008-06-02 2009-12-03 Po-Jui Chen System, apparatus and method for biomedical wireless pressure sensing
WO2010100654A2 (en) * 2009-01-30 2010-09-10 Panduranga Revankar Krishna Prasad A device to directly monitor intra ocular pressure by a person based on pattern and colour changes
WO2011082314A2 (en) * 2009-12-30 2011-07-07 Brockman Holdings Llc System, device, and method for determination of intraocular pressure

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004062480A2 (en) * 2003-01-09 2004-07-29 The Regents Of The University Of California Implantable devices and methods for measuring intraocular, subconjunctival or subdermal pressure and/or analyte concentration
DE102005041271A1 (de) * 2005-08-31 2007-03-01 Carl Zeiss Meditec Ag Verfahren zur Ermittlung einer Konzentration wenigstens eines Stoffes im Kammerwasser und/oder im Gewebe des Auges und Implantat zur Durchführung des Verfahrens
WO2007035356A2 (en) * 2005-09-16 2007-03-29 Bg Implant, Inc. Glaucoma treatment devices and methods
US20090299216A1 (en) * 2008-06-02 2009-12-03 Po-Jui Chen System, apparatus and method for biomedical wireless pressure sensing
WO2010100654A2 (en) * 2009-01-30 2010-09-10 Panduranga Revankar Krishna Prasad A device to directly monitor intra ocular pressure by a person based on pattern and colour changes
WO2011082314A2 (en) * 2009-12-30 2011-07-07 Brockman Holdings Llc System, device, and method for determination of intraocular pressure

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016064867A3 (en) * 2014-10-20 2016-08-25 The Regents Of The University Of California Optical intraocular sensor and sensing method

Also Published As

Publication number Publication date
IN2014KN02968A (enCached4) 2015-05-08
US20150157453A1 (en) 2015-06-11
DE102012105129A1 (de) 2013-12-19
EP2861126A1 (de) 2015-04-22
US9730788B2 (en) 2017-08-15
EP2861126B1 (de) 2021-01-20

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