WO2013177599A1 - Composition nutricosmétique - Google Patents
Composition nutricosmétique Download PDFInfo
- Publication number
- WO2013177599A1 WO2013177599A1 PCT/ZA2012/000036 ZA2012000036W WO2013177599A1 WO 2013177599 A1 WO2013177599 A1 WO 2013177599A1 ZA 2012000036 W ZA2012000036 W ZA 2012000036W WO 2013177599 A1 WO2013177599 A1 WO 2013177599A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- mass
- nutricosmetic
- test
- skin
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Definitions
- the invention relates to a nutricosmetic composition which when taken orally or topically reduces the appearance of wrinkles in the skin and makes the skin look younger and fresher.
- Cosmeceuticals represent the marriage of cosmetics and pharmaceuticals. Examples of products typically labeled as cosmeceuticals include anti-aging creams and moisturizers. Cosmeceuticals are cosmetic products with biologically active ingredients purporting to have medical or drug-like benefits. Dermatological research suggests that the bioactive ingredients used in cosmeceuticals do indeed have benefits beyond the traditional moisturizer (e.g., Chen et al., 2005; Zettersten, Ghadially, Feingold, Crumrine, & Elias, 1997).
- a nutricosmetic composition including at least: a stibenoid; a catechin; a benzoquinone; and a piperine or a derivative or extract thereof.
- the stibenoid may be fraA7s-3,5,4 , -Trihydroxystilbene ) an analogue or an isomer thereof, or a mixture or blend of said analogues and isomers.
- the catechin may be [(2 ?,3f?)-5,7-dihydroxy-2-(3 I 4,5-trihydroxyphenyl)chroman-3- yl]3,4,5-trihydroxybenzoate, an analogue or an isomer thereof, or a mixture or blend of said analogues and isomers.
- the benzoquinone may be 2-[(2£,6E,10£, 4E,18£,22E,26E,30E,34E)- 3,7,11 ,15,19,23,27,31 ,35,39-decamethyltetraconta-2,6,10,14, 18,22,26,30,34,38- decaenyl]-5, 6-dimethoxy-3-methylcyclohexa-2,5-diene-1 ,4-dione, an analogue or an isomer thereof, or a mixture or blend of said analogues and isomers.
- the piperine may be 1-[5-(1 ,3-benzodioxol- 5-yl)-1-oxo-2,4-pentadienyl]piperidine, an analogue or an isomer thereof, or a mixture or blend of said analogues and isomers.
- the composition may include one or more fats, oils, and waxes.
- the fats, oils, and waxes may be of biological origin.
- the fats and oils may be of vegetable origin.
- the waxes may be of arthropod origin.
- the composition may include one or more phospholipids of plant or animal origin.
- the phospholipids may be esters of a phosphatidic acid with choline.
- the phospholipid may be lecithin.
- the composition may include one or more excipients such as gelatine, C3O3H8, water, colourants, preservatives, flavourings, and the like. The choice of excipients is to some extent a choice based on the form, taste and smell of the nutricosmetic composition dosage form desired.
- the nutricosmetic composition may be administered in the form of a liquid or gel capsule, such as that known as a softgel.
- the nutricosmetic composition may have a composition as follows:
- a softgel form having a wet mass of from 400 mg to 1500 mg per softgel unit, provided that sum of the selected mass% of the ingredients adds up to 100%.
- the invention extends to the use of a composition of the invention in a nutricosmetic formulation administered orally, for the improved appearance of the skin of the person taking same.
- the nutricosmetic composition when taken once daily as a soft gel having: approx. 20 mass% of trans-3, 5,4'-Trihydroxystilbene;
- the Corneometer was calibrated with supplier calibration set.
- the temperature and relative humidity were recorded during the time of the study.
- test subjects An operator trained the test subjects in applying the test products evenly to the test sites, according to the test substance sequence. Subjects were verbally instructed on oral intake of the supplied test capsule.
- the Corneometer was calibrated with supplier calibration set. The temperature and relative humidity were recorded during the time of the study.
- the designated day readings were taken at three different test sites.
- the corneometer probe was gently cleaned with a tissue between each reading.
- the measurement of skin moisture is via capacitance using a CORNEOMETER 825. This measurement is based on the different dielectric constants of water (81 ) and other substances ( ⁇ 7). The measuring capacitor shows changes of capacitance according to the moisture content of the sample. (Courage and Khazaka Gmbh 2010).
- Air humidity and room temperature will be controlled, as the higher the temperature and Humidity the higher the skin's moisture level (Report 1990).
- An increase in the value indicates an increase in moisture content, where 0 indicates no moisture and 100 indicates water.
- Results A Wilcoxon Signed Rank Sum Test was performed to compare the treated and the placebo sites at baseline (thus before application of test products) and no statistical significant difference was found between the two test sites on a 5% level of significance.
- a Wilcoxon Signed Rank Sum Test was performed to determine the treatment effect by comparing the average values at day fourteen (D 4) of the treated and placebo sites and there was a statistical significance difference on a 5% level of significance. The average values for the treated sites were significantly bigger than the Placebo sites.
- a t-Test was performed to determine the treatment effect by comparing the average values at day twenty-eight (D28) of the treated and placebo sites and there was no statistical significance difference on a 5% level of significance.
- a t-Test was performed to determine the treatment effect by comparing the average values at day fifty-six (D56) of the treated and placebo sites and there was no statistical significance difference on a 5% level of significance.
- test softgel group was effective in increasing the moisture level after fourteen days(D14) of consecutive use (one oral capsule) when compared to a placebo cell.
- the objective of the study was to determine the Smoothness efficacy of a test product on the face of human subjects.
- the designated left or right hand and matching side of the face was cleansed with a standard eye make-up remover and allowed to air dry for three minutes.
- the temperature and relative humidity were recorded during the time of the study.
- test sites were demarcated as per test sequence substance. Three (3) baseline readings were taken at the different test sites.
- Subjects were restricted from using any topical products or any medication not approved by the study sponsor for the duration of the study. Subjects returned to the testing facility on days 14, 28, 56 respectively after baseline readings.
- the temperature and relative humidity were recorded during the time of the study.
- the designated day readings were taken at three different test sites.
- the visioscan camera was gently cleaned with a tissue between each reading.
- Results A Wilcoxon Signed Rank Sum Test was performed to compare the treated and the placebo sites at baseline (thus before application of test products) and no statistical significant difference was found between the two test sites on a 5% level of significance.
- a Wilcoxon Signed Rank Sum Test was performed to determine the treatment effect by comparing the average values at day fourteen (D14) of the treated and placebo sites and there was a statistical significance difference on a 5% level of significance. The average values for the treated sites were significantly bigger than the Placebo sites.
- a t-Test was performed to determine the treatment effect by comparing the average values at day twenty-eight (D28) of the treated and placebo sites and there was a statistical significance difference on a 5% level of significance. The average values for the treated sites were significantly bigger than the Placebo sites. A t-Test was performed to determine the treatment effect by comparing the average values at day fifty-six (D56) of the treated and placebo sites and there was no statistical significance difference on a 5% level of significance.
- test softgel group was effective in increasing the smoothness level after fourteen (D14) and twenty-eight (D28) days of consecutive use (one oral capsule) when compared to a placebo cell.
- the objective of the study was to determine the elasticity efficacy of a test product on the hands and face of human subjects.
- Method Four groups of at least twenty (20) subjects between the ages of 18 and 68 were recruited.
- the designated left or right hand and matching side of the face was cleansed with a standard eye make-up remover and allowed to air dry for three minutes.
- the temperature and relative humidity were recorded during the time of the study.
- test sites were demarcated as per test sequence substance. Three (3) baseline readings were taken at the different test sites.
- Subjects returned to the testing facility on days 14, 28, 56 respectively after baseline readings. All Subjects were instructed to rest for twenty minutes before any testing was conducted.
- the temperature and relative humidity were recorded during the time of the study.
- the designated day readings were taken at three different test sites.
- the cutometer probe was gently cleaned with a tissue between each reading.
- Results A t-Test was performed to compare the treated and the placebo sites at baseline (thus before application of test products) and no statistical significant difference was found between the two test sites on a 5% level of significance.
- a Wilcoxon Signed Rank Sum Test was performed to determine the treatment effect by comparing the day fourteen (D14-D0) values at of the treated and placebo sites and there was no statistical significance difference on a 5% level of significance.
- a Wilcoxon Signed Rank Sum Test was performed to determine the treatment effect by comparing the day twenty-eight (D28-D0) values of the treated and placebo sites and there was no statistical significance difference on a 5% level of significance.
- test softgel group was not effective in increasing the elasticity level after fourteen (D14), twenty-eight (D28) days and fifty-six days (D56) of consecutive use (one oral capsule) when compared to a placebo cell.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
L'invention concerne une composition nutricosmétique comprenant au moins un stilbénoïde, une catéchine, une benzoquinone et une pipérine, ou un dérivé, ou un extrait de ceux-ci. L'invention s'étend à un procédé d'amélioration de l'apparence de la peau d'une personne par l'administration d'une capsule molle de la composition décrite dans l'invention.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/ZA2012/000036 WO2013177599A1 (fr) | 2012-05-22 | 2012-05-22 | Composition nutricosmétique |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/ZA2012/000036 WO2013177599A1 (fr) | 2012-05-22 | 2012-05-22 | Composition nutricosmétique |
Publications (1)
Publication Number | Publication Date |
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WO2013177599A1 true WO2013177599A1 (fr) | 2013-11-28 |
Family
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Family Applications (1)
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PCT/ZA2012/000036 WO2013177599A1 (fr) | 2012-05-22 | 2012-05-22 | Composition nutricosmétique |
Country Status (1)
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WO (1) | WO2013177599A1 (fr) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080003307A1 (en) * | 2006-06-28 | 2008-01-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods and systems for analysis of nutraceutical associated components |
WO2008134712A2 (fr) * | 2007-04-30 | 2008-11-06 | Living Proof, Inc. | Utilisation d'inhibiteurs de la métalloprotéinase de la matrice pour les soins de la peau |
WO2010118419A2 (fr) * | 2009-04-10 | 2010-10-14 | Haiyan Qi | Nouveaux agents anti-vieillissement et leurs procédés d'identification |
JP2011184429A (ja) * | 2010-02-10 | 2011-09-22 | Univ Of Tsukuba | 低分子抗酸化剤及び高分子化環状ニトロキシドラジカル化合物を含む組成物 |
-
2012
- 2012-05-22 WO PCT/ZA2012/000036 patent/WO2013177599A1/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080003307A1 (en) * | 2006-06-28 | 2008-01-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods and systems for analysis of nutraceutical associated components |
WO2008134712A2 (fr) * | 2007-04-30 | 2008-11-06 | Living Proof, Inc. | Utilisation d'inhibiteurs de la métalloprotéinase de la matrice pour les soins de la peau |
WO2010118419A2 (fr) * | 2009-04-10 | 2010-10-14 | Haiyan Qi | Nouveaux agents anti-vieillissement et leurs procédés d'identification |
JP2011184429A (ja) * | 2010-02-10 | 2011-09-22 | Univ Of Tsukuba | 低分子抗酸化剤及び高分子化環状ニトロキシドラジカル化合物を含む組成物 |
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