WO2013168006A3 - Compositions et méthodes de traitement de la douleur locale - Google Patents

Compositions et méthodes de traitement de la douleur locale Download PDF

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Publication number
WO2013168006A3
WO2013168006A3 PCT/IB2013/051268 IB2013051268W WO2013168006A3 WO 2013168006 A3 WO2013168006 A3 WO 2013168006A3 IB 2013051268 W IB2013051268 W IB 2013051268W WO 2013168006 A3 WO2013168006 A3 WO 2013168006A3
Authority
WO
WIPO (PCT)
Prior art keywords
pain
treatment
neuralgia
compositions
compounds
Prior art date
Application number
PCT/IB2013/051268
Other languages
English (en)
Other versions
WO2013168006A2 (fr
Inventor
Mahesh Kandula
Original Assignee
Cellixbio Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellixbio Private Limited filed Critical Cellixbio Private Limited
Priority to SG11201407323WA priority Critical patent/SG11201407323WA/en
Priority to CA2873138A priority patent/CA2873138A1/fr
Priority to CN201380030659.5A priority patent/CN105612155A/zh
Priority to JP2015510898A priority patent/JP2016508956A/ja
Priority to EP13788349.2A priority patent/EP2882745A2/fr
Priority to AU2013257727A priority patent/AU2013257727B2/en
Publication of WO2013168006A2 publication Critical patent/WO2013168006A2/fr
Priority to ZA2014/08055A priority patent/ZA201408055B/en
Publication of WO2013168006A3 publication Critical patent/WO2013168006A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La présente invention concerne des composés de formule I ou leurs sels pharmaceutiquement acceptables, ainsi que leurs formes polymorphes, leurs solvates, leurs énantiomères, leurs stéréoisomères et leurs hydrates. Elle concerne des compositions pharmaceutiques comprenant une quantité efficace de composés de formule I; et des méthodes de traitement de la douleur locale. Ces compositions peuvent être formulées pour administration par voie orale, buccale, rectale, topique, transdermique, transmuqueuse, intraveineuse, parentérale, sous forme de sirop ou d'injection. Ces compositions peuvent être utilisées pour traitement par anesthésie par infiltration, anesthésie tronculaire, anesthésie péridurale ou anesthésie intrathécale. Elles peuvent être utilisées pour traiter la douleur, la douleur sévère, la douleur chronique, la douleur induite par la chimiothérapie, la douleur neuropathique, la névralgie post-herpétique, la névralgie, la maladie des motoneurones, la neuropathie diabétique, les lésions, la douleur postopératoire, l'arthrose, la polyarthrite rhumatoïde, la sclérose en plaques, les lésions de la moelle épinière, la migraine, la douleur neuropathique liée au VIH, la douleur cancéreuse, et la douleur du bas du dos.
PCT/IB2013/051268 2012-05-10 2013-02-16 Compositions et méthodes de traitement de la douleur locale WO2013168006A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
SG11201407323WA SG11201407323WA (en) 2012-05-10 2013-02-16 Compositions and methods for the treatment of local pain
CA2873138A CA2873138A1 (fr) 2012-05-10 2013-02-16 Compositions et methodes de traitement de la douleur locale
CN201380030659.5A CN105612155A (zh) 2012-05-10 2013-02-16 治疗局部疼痛的组合物和方法
JP2015510898A JP2016508956A (ja) 2012-05-10 2013-02-16 局所疼痛の治療のための組成物と治療法
EP13788349.2A EP2882745A2 (fr) 2012-05-10 2013-02-16 Compositions et méthodes de traitement de la douleur locale
AU2013257727A AU2013257727B2 (en) 2012-05-10 2013-02-16 Compositions and methods for the treatment of local pain
ZA2014/08055A ZA201408055B (en) 2012-05-10 2014-11-04 Compositions and methods for the treatment of local pain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1843/CHE/2012 2012-05-10
IN1843CH2012 2012-05-10

Publications (2)

Publication Number Publication Date
WO2013168006A2 WO2013168006A2 (fr) 2013-11-14
WO2013168006A3 true WO2013168006A3 (fr) 2016-09-01

Family

ID=54193695

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2013/051268 WO2013168006A2 (fr) 2012-05-10 2013-02-16 Compositions et méthodes de traitement de la douleur locale

Country Status (8)

Country Link
EP (1) EP2882745A2 (fr)
JP (1) JP2016508956A (fr)
CN (1) CN105612155A (fr)
AU (1) AU2013257727B2 (fr)
CA (1) CA2873138A1 (fr)
SG (1) SG11201407323WA (fr)
WO (1) WO2013168006A2 (fr)
ZA (1) ZA201408055B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8361067B2 (en) 2002-09-30 2013-01-29 Relievant Medsystems, Inc. Methods of therapeutically heating a vertebral body to treat back pain
US10588691B2 (en) 2012-09-12 2020-03-17 Relievant Medsystems, Inc. Radiofrequency ablation of tissue within a vertebral body
IL238516B (en) 2012-11-05 2022-08-01 Relievant Medsystems Inc System and methods for creating curved pathways through bone and regulating the nerves within the bone
US9724151B2 (en) 2013-08-08 2017-08-08 Relievant Medsystems, Inc. Modulating nerves within bone using bone fasteners
BR112019013192A2 (pt) * 2016-12-26 2019-12-10 Cellix Bio Private Ltd composto e composição farmacêutica
CA3150339A1 (fr) 2019-09-12 2021-03-18 Brian W. Donovan Systemes et methodes de modulation de tissu

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1126435A (zh) * 1993-06-28 1996-07-10 阿斯特拉公司 罗哌卡因在具有最小运动神经阻断的止痛作用的药物制造中的应用
CN1279607A (zh) * 1997-11-19 2001-01-10 达尔文发现有限公司 麻醉制剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1187813A (zh) * 1995-05-01 1998-07-15 斯科舍集团有限公司 作为生物活性化合物的脂肪酸酯
GB9704349D0 (en) * 1997-03-03 1997-04-23 Chiroscience Ltd Levobupivacaine and its use
JP4880190B2 (ja) * 2001-04-30 2012-02-22 トロムスドルフ ゲーエムベーハー ウント コンパニー カーゲー アルツナイミッテル 医薬として活性なウリジンエステル
EP2209450A4 (fr) * 2007-11-07 2013-09-25 Svip5 Llc Libération lente de sels organiques d'anesthésique local pour un soulagement de la douleur
US8846068B2 (en) * 2008-04-18 2014-09-30 Warsaw Orthopedic, Inc. Methods and compositions for treating post-operative pain comprising a local anesthetic
WO2013024320A1 (fr) * 2011-08-17 2013-02-21 Mahesh Kandula Dérivés de 2,6-xylidine pour le traitement de la douleur

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1126435A (zh) * 1993-06-28 1996-07-10 阿斯特拉公司 罗哌卡因在具有最小运动神经阻断的止痛作用的药物制造中的应用
CN1279607A (zh) * 1997-11-19 2001-01-10 达尔文发现有限公司 麻醉制剂

Also Published As

Publication number Publication date
AU2013257727A1 (en) 2014-11-27
CA2873138A1 (fr) 2013-11-14
SG11201407323WA (en) 2014-12-30
JP2016508956A (ja) 2016-03-24
AU2013257727B2 (en) 2016-04-28
CN105612155A (zh) 2016-05-25
ZA201408055B (en) 2016-03-30
WO2013168006A2 (fr) 2013-11-14
EP2882745A2 (fr) 2015-06-17

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