WO2013166413A3 - Compositions et procédés pour augmenter des peptides neurotrophiques - Google Patents

Compositions et procédés pour augmenter des peptides neurotrophiques Download PDF

Info

Publication number
WO2013166413A3
WO2013166413A3 PCT/US2013/039508 US2013039508W WO2013166413A3 WO 2013166413 A3 WO2013166413 A3 WO 2013166413A3 US 2013039508 W US2013039508 W US 2013039508W WO 2013166413 A3 WO2013166413 A3 WO 2013166413A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
pharmaceutically
increasing
pharmaceutical composition
Prior art date
Application number
PCT/US2013/039508
Other languages
English (en)
Other versions
WO2013166413A2 (fr
Inventor
John M. BEALE
Original Assignee
Saint Louis College Of Pharmacy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Saint Louis College Of Pharmacy filed Critical Saint Louis College Of Pharmacy
Priority to CN201380023195.5A priority Critical patent/CN104470515B/zh
Priority to CA2871926A priority patent/CA2871926A1/fr
Priority to EP13784625.9A priority patent/EP2844251B1/fr
Priority to US14/398,704 priority patent/US9687488B2/en
Publication of WO2013166413A2 publication Critical patent/WO2013166413A2/fr
Publication of WO2013166413A3 publication Critical patent/WO2013166413A3/fr
Priority to US15/632,049 priority patent/US20170290835A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne une composition pharmaceutique qui inclut un excipient pharmaceutiquement acceptable et une quantité pharmaceutiquement et physiquement acceptable d'un composé sélectionné dans le groupe constitué des formules chimiques I-IV comme décrites ici, ou d'un sel pharmaceutiquement acceptable de celui-ci. L'invention concerne aussi des procédés d'augmentation d'un taux d'un peptide neurotrophique défini dans un organisme ou un tissu comprenant l'administration d'une quantité pharmaceutiquement et physiquement acceptable d'une ou de plusieurs des compositions décrites ci-dessus et un procédé pour le traitement d'une maladie neurodégénérative chez un sujet nécessitant celui-ci, le procédé comprenant l'administration d'une quantité thérapeutiquement efficace de la composition pharmaceutique selon la revendication 1.
PCT/US2013/039508 2012-05-03 2013-05-03 Compositions et procédés pour augmenter des peptides neurotrophiques WO2013166413A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN201380023195.5A CN104470515B (zh) 2012-05-03 2013-05-03 用于增加神经营养肽的组合物和方法
CA2871926A CA2871926A1 (fr) 2012-05-03 2013-05-03 Compositions et procedes pour augmenter des peptides neurotrophiques
EP13784625.9A EP2844251B1 (fr) 2012-05-03 2013-05-03 Compositions et procédés pour augmenter des peptides neurotrophiques
US14/398,704 US9687488B2 (en) 2012-05-03 2013-05-03 Compositions and methods for increasing neurotrophic peptides
US15/632,049 US20170290835A1 (en) 2012-05-03 2017-06-23 Compositions and methods for increasing neurotrophic peptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261642086P 2012-05-03 2012-05-03
US61/642,086 2012-05-03

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/398,704 A-371-Of-International US9687488B2 (en) 2012-05-03 2013-05-03 Compositions and methods for increasing neurotrophic peptides
US15/632,049 Continuation US20170290835A1 (en) 2012-05-03 2017-06-23 Compositions and methods for increasing neurotrophic peptides

Publications (2)

Publication Number Publication Date
WO2013166413A2 WO2013166413A2 (fr) 2013-11-07
WO2013166413A3 true WO2013166413A3 (fr) 2014-01-03

Family

ID=49515044

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/039508 WO2013166413A2 (fr) 2012-05-03 2013-05-03 Compositions et procédés pour augmenter des peptides neurotrophiques

Country Status (5)

Country Link
US (2) US9687488B2 (fr)
EP (1) EP2844251B1 (fr)
CN (1) CN104470515B (fr)
CA (1) CA2871926A1 (fr)
WO (1) WO2013166413A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9687488B2 (en) 2012-05-03 2017-06-27 St. Louis College Of Pharmacy Compositions and methods for increasing neurotrophic peptides

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0970084B1 (fr) * 1997-03-19 2003-06-04 Basf Aktiengesellschaft Pyrrolo 2,3] pyrimidines et leur utilisation comme inhibiteurs de la tyrosine kinase
US20090171086A1 (en) * 2002-02-01 2009-07-02 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds and their uses
WO2010141074A2 (fr) * 2009-06-01 2010-12-09 President And Fellows Of Harvard College Inhibiteurs de la o-glcnac transférase et leurs utilisations
US20110136880A1 (en) * 2009-12-08 2011-06-09 Khalid El Sayed Latrunculin-Based Macrolides and Their Uses
EP2415765A1 (fr) * 2009-03-30 2012-02-08 Astellas Pharma Inc. Composé pyrimidine
US8129394B2 (en) * 2008-03-21 2012-03-06 Novartis Ag Heteroaryl-substituted imidazole compounds and uses thereof
US20120088775A1 (en) * 2009-06-08 2012-04-12 Peking University Pyrazolo-[1,5-a]-Pyrimidones Derivatives and Pharmaceutical Compositions and Uses Thereof
US8168654B2 (en) * 2003-05-02 2012-05-01 Novartis Ag Quinuclidine derivatives binding to mucarinic M3 receptors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008076262A2 (fr) * 2006-12-15 2008-06-26 Merck & Co., Inc. Récepteur pour bêta amyloïde et utilisations de celui-ci
WO2010022175A1 (fr) * 2008-08-19 2010-02-25 Yale University Identification de la sortiline en tant que récepteur neuronal pour la protéine de la démence frontotemporale, la progranuline
US9687488B2 (en) * 2012-05-03 2017-06-27 St. Louis College Of Pharmacy Compositions and methods for increasing neurotrophic peptides

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0970084B1 (fr) * 1997-03-19 2003-06-04 Basf Aktiengesellschaft Pyrrolo 2,3] pyrimidines et leur utilisation comme inhibiteurs de la tyrosine kinase
US20090171086A1 (en) * 2002-02-01 2009-07-02 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds and their uses
US8168654B2 (en) * 2003-05-02 2012-05-01 Novartis Ag Quinuclidine derivatives binding to mucarinic M3 receptors
US8129394B2 (en) * 2008-03-21 2012-03-06 Novartis Ag Heteroaryl-substituted imidazole compounds and uses thereof
EP2415765A1 (fr) * 2009-03-30 2012-02-08 Astellas Pharma Inc. Composé pyrimidine
WO2010141074A2 (fr) * 2009-06-01 2010-12-09 President And Fellows Of Harvard College Inhibiteurs de la o-glcnac transférase et leurs utilisations
US20120088775A1 (en) * 2009-06-08 2012-04-12 Peking University Pyrazolo-[1,5-a]-Pyrimidones Derivatives and Pharmaceutical Compositions and Uses Thereof
US20110136880A1 (en) * 2009-12-08 2011-06-09 Khalid El Sayed Latrunculin-Based Macrolides and Their Uses

Also Published As

Publication number Publication date
CA2871926A1 (fr) 2013-11-07
US20150126531A1 (en) 2015-05-07
CN104470515B (zh) 2016-12-07
EP2844251A2 (fr) 2015-03-11
US20170290835A1 (en) 2017-10-12
US9687488B2 (en) 2017-06-27
EP2844251A4 (fr) 2016-04-06
EP2844251B1 (fr) 2018-08-01
WO2013166413A2 (fr) 2013-11-07
CN104470515A (zh) 2015-03-25

Similar Documents

Publication Publication Date Title
AU2018201997B2 (en) Peptides which inhibit activated receptors and their use in cosmetic or pharmaceutical compositions
WO2014165607A3 (fr) Formulations peptidiques cationiques aromatiques, compositions et procédés d'utilisation
MX2017004592A (es) Formulaciones farmaceuticas para la administracion oral de farmacos peptidicos o proteinicos.
WO2011127333A3 (fr) Composés pour le traitement d'une maladie, pour l'administration, et pour des compositions pharmaceutiques
WO2014205229A8 (fr) Utilisation de pridopidine à forte dose pour traiter la maladie de huntington
WO2013052699A3 (fr) Nouveaux inhibiteurs de quinoxaline de la voie pi3k
WO2015183963A3 (fr) Compositions thérapeutiques comprenant des parabenzoquinones à activité redox et leurs utilisations
WO2013188792A3 (fr) Stéroïdes neuroactifs, compositions, et leurs utilisations
UA109698C2 (xx) Похідні азаіндазолу або діазаіндазолу як медикамент
WO2012118812A3 (fr) Composés hétéroaryles bicycliques substitués condensés en 6,5
MX2015008396A (es) Derivados de la 2,3-dihidro-isoindol-1-ona, como inhibidores de la btk quinasa y composiciones farmacéuticas que los incluyen.
CA3030422C (fr) Excipients stabilisants pour formulations de proteines therapeutiques
NO20100301L (no) Forbedrete brimonidinsammensetninger for behandling av erytem
EA201270144A1 (ru) Комбинированная терапия при лечении диабета
ES2397889A1 (es) PÉPTIDOS MODULADORES DE PGC-1Alfa.
WO2011118976A3 (fr) Composition pharmaceutique pour la prévention ou le traitement d'une stéatose hépatique non alcoolique et procédé pour la prévention ou le traitement de la stéatose hépatique non alcoolique utilisant celle-ci
WO2012007159A3 (fr) Nouvelles formes médicamenteuses à rétention gastrique
WO2013085849A3 (fr) Esters de sulfate de noribogaïne
EA201492010A1 (ru) Применение высокой дозы лахинимода для лечения рассеянного склероза
WO2012116176A3 (fr) Urées asymétriques et utilisations médicales de celles-ci
WO2016210376A3 (fr) Peptides thérapeutiques et leurs procédés d'utilisation
WO2011097946A8 (fr) Composés oxazolidinone contenant deux cycles fusionnés, procédé de préparation associé et utilisation associée
WO2012053013A3 (fr) Compositions pharmaceutiques d'agents anti-acné
WO2012161497A3 (fr) Dérivés peptidiques ayant un effet hydratant supérieur et leurs utilisations
EA201171087A1 (ru) СПОСОБЫ ВВЕДЕНИЯ (4aR,10aR)-1-н-ПРОПИЛ-1,2,3,4,4a,5,10,10a-ОКТАГИДРОБЕНЗО[g]ХИНОЛИН-6,7-ДИОЛА И РОДСТВЕННЫХ СОЕДИНЕНИЙ ЧЕРЕЗ СЛИЗИСТУЮ ОБОЛОЧКУ ПОЛОСТИ РТА, СЛИЗИСТУЮ ОБОЛОЧКУ НОСА ИЛИ КОЖУ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ НА ИХ ОСНОВЕ

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13784625

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2871926

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 14398704

Country of ref document: US

REEP Request for entry into the european phase

Ref document number: 2013784625

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2013784625

Country of ref document: EP