WO2013145711A1 - Dispositif de diagnostic d'image et procédé de commande pour celui-ci - Google Patents

Dispositif de diagnostic d'image et procédé de commande pour celui-ci Download PDF

Info

Publication number
WO2013145711A1
WO2013145711A1 PCT/JP2013/002037 JP2013002037W WO2013145711A1 WO 2013145711 A1 WO2013145711 A1 WO 2013145711A1 JP 2013002037 W JP2013002037 W JP 2013002037W WO 2013145711 A1 WO2013145711 A1 WO 2013145711A1
Authority
WO
WIPO (PCT)
Prior art keywords
reception unit
transmission
ultrasonic
optical
tomographic image
Prior art date
Application number
PCT/JP2013/002037
Other languages
English (en)
Japanese (ja)
Inventor
賢二 金子
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Priority to JP2014507429A priority Critical patent/JP6062421B2/ja
Publication of WO2013145711A1 publication Critical patent/WO2013145711A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4416—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to combined acquisition of different diagnostic modalities, e.g. combination of ultrasound and X-ray acquisitions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • A61B8/445—Details of catheter construction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • A61B8/4461—Features of the scanning mechanism, e.g. for moving the transducer within the housing of the probe

Definitions

  • the present invention relates to a technique for generating a tomographic image of a biological tissue by ultrasonic cutting and light.
  • diagnostic imaging devices have been widely used for diagnosis of arteriosclerosis, preoperative diagnosis at the time of endovascular treatment with a high-function catheter such as a balloon catheter or a stent, or confirmation of postoperative results.
  • the diagnostic imaging apparatus includes an intravascular ultrasound diagnostic apparatus (IVUS: Intra Vascular Ultra Sound), an optical coherence tomography diagnostic apparatus (OCT: Optical Coherence Tomography), and the like, each having different characteristics.
  • IVUS Intra Vascular Ultra Sound
  • OCT optical coherence tomography diagnostic apparatus
  • a tomographic image is generated by transmitting / receiving ultrasonic waves or light in a transmitting / receiving unit while operating a probe unit in an axial direction and a rotating direction in a blood vessel.
  • each of the IVUS transceiver unit and the OCT transceiver unit requires a corresponding physical installation space, and therefore cannot be arranged at the same position.
  • both are placed at different positions in the probe. Therefore, the respective vascular tomograms obtained by both are shifted by an amount corresponding to the arrangement position. Therefore, in order to be able to compare both tomographic images at the same position and the same viewpoint, it is necessary to adjust one tomographic image according to the difference in positioning.
  • the higher the positioning accuracy the worse the yield and the greater the cost problem.
  • the present invention has been made in view of such a problem, and does not require high positioning accuracy for the ultrasonic transmission / reception unit and the optical transmission / reception unit in the probe, and is based on the relative positions of the ultrasonic transmission / reception unit and the optical transmission / reception unit. It is an object of the present invention to provide a technique that makes it possible to generate an ultrasonic tomographic image and an optical tomographic image corrected for the above.
  • the diagnostic imaging apparatus has the following configuration. That is, An ultrasonic transmission / reception unit for transmitting / receiving ultrasonic waves, and an optical transmission / reception unit for transmitting / receiving light, the probe having a transmission / reception unit, and holding the probe rotatably and detachably, the ultrasonic transmission / reception unit An image diagnostic apparatus that generates an ultrasonic tomographic image and an optical tomographic image of a biological tissue using a reflected wave from the biological tissue received by the optical transmitter and a reflected light from the biological tissue received by the optical transceiver.
  • Read means for accessing a predetermined memory mounted on the probe, and reading information relating to the arrangement position of the ultrasonic transmission / reception unit and the optical transmission / reception unit from the memory; Diagnostic information generating means for generating an ultrasonic tomographic image and an optical tomographic image in which the deviation according to the arrangement position is corrected from the information acquired through the reading means.
  • an ultrasonic tomographic image in which a deviation based on the relative positions of the ultrasonic transmission / reception unit and the optical transmission / reception unit is corrected without requiring high positioning accuracy for the ultrasonic transmission / reception unit and the optical transmission / reception unit in the probe.
  • An optical tomographic image can be generated.
  • FIG. 1 is a diagram showing an external configuration of a diagnostic imaging apparatus 100 according to an embodiment of the present invention. It is a figure which shows the whole structure of a probe part, and the cross-sectional structure of a front-end
  • 2 is a diagram illustrating a functional configuration of the diagnostic imaging apparatus 100.
  • FIG. 1 is a diagram showing an external configuration of an image diagnostic apparatus (an image diagnostic apparatus having an IVUS function and an OCT function) 100 according to an embodiment of the present invention.
  • the diagnostic imaging apparatus 100 includes a probe unit 101, a scanner / pullback unit 102, and an operation control device 103, and the scanner / pullback unit 102 and the operation control device 103 are connected by a signal line 104. Various signals are connected so that transmission is possible.
  • the probe unit 101 is directly inserted into a body cavity such as a blood vessel and transmits an ultrasonic wave based on a pulse signal into the body cavity and receives a reflected wave from the body cavity, and transmitted light (measurement).
  • An imaging core including an optical transmission / reception unit that continuously transmits light) into a body cavity and continuously receives reflected light from inside the body cavity is inserted.
  • the state inside the body cavity is measured by using the imaging core.
  • the scanner / pullback unit 102 is detachably attached to the probe unit 101, and operates in the axial direction and the rotational direction of the imaging core inserted in the probe unit 101 by driving a built-in motor (the axial direction in the body cavity). And movement in the rotation direction). Further, the reflected wave received by the ultrasonic transmission / reception unit and the reflected light received by the optical transmission / reception unit are acquired and transmitted to the operation control apparatus 103.
  • the operation control device 103 has a function for inputting various set values and a function for processing data obtained by the measurement and displaying it as a tomographic image in the body cavity when performing the measurement.
  • 111 is a main body control unit, which generates ultrasonic data based on the reflected wave obtained by measurement, and processes the line data generated based on the ultrasonic data, An ultrasonic tomographic image is generated. Further, interference light data is generated by causing interference between the reflected light obtained by measurement and the reference light obtained by separating the light from the light source, and line data generated based on the interference light data. To generate an optical tomographic image.
  • 111-1 is a printer / DVD recorder, which prints the processing result in the main body control unit 111 or stores it as data.
  • Reference numeral 112 denotes an operation panel, and the user inputs various setting values and instructions via the operation panel 112.
  • Reference numeral 113 denotes an LCD monitor as a display device, which displays a tomographic image generated by the main body control unit 111.
  • the probe unit 101 includes a long catheter sheath 201 inserted into a body cavity such as a blood vessel and a user's hand without being inserted into a body cavity such as a blood vessel for operation by the user. It is comprised by the connector part 202 arrange
  • a guide wire lumen tube 203 constituting a guide wire lumen is provided at the distal end of the catheter sheath 201.
  • the catheter sheath 201 forms a continuous lumen from a connection portion with the guide wire lumen tube 203 to a connection portion with the connector portion 202.
  • a transmission / reception unit 221 Inside the lumen of the catheter sheath 201 is provided with a transmission / reception unit 221 in which an ultrasonic transmission / reception unit for transmitting / receiving ultrasonic waves and an optical transmission / reception unit for transmitting / receiving light, an electric signal cable and an optical fiber cable are provided.
  • An imaging core 220 including a coil-shaped drive shaft 222 that transmits a rotational drive force for rotating the catheter sheath 201 is inserted over almost the entire length of the catheter sheath 201.
  • the connector portion 202 includes a sheath connector 202a configured integrally with the proximal end of the catheter sheath 201, and a drive shaft connector 202b configured by rotatably fixing the drive shaft 222 to the proximal end of the drive shaft 222.
  • a kink protector 211 is provided at the boundary between the sheath connector 202a and the catheter sheath 201. Thereby, predetermined rigidity is maintained, and bending (kink) due to a sudden change in physical properties can be prevented.
  • the base end of the drive shaft connector 202b is detachably attached to the scanner / pullback unit 102.
  • a housing 223 Inside the lumen of the catheter sheath 201 is a housing 223 in which an ultrasonic transmission / reception unit for transmitting / receiving ultrasonic waves and an optical transmission / reception unit for transmitting / receiving light are arranged, and a rotation for rotating the housing 223
  • An imaging core 220 including a driving shaft 222 that transmits a driving force is inserted through substantially the entire length to form the probe unit 101.
  • the transmission / reception unit 221 transmits ultrasonic waves and light toward the tissue in the body cavity and receives reflected waves and reflected light from the tissue in the body cavity.
  • the drive shaft 222 is formed in a coil shape, and an electric signal cable and an optical fiber cable (single-mode optical fiber cable) are arranged therein.
  • the housing 223 has a shape having a notch in a part of a short cylindrical metal pipe, and is formed by cutting out from a metal lump, MIM (metal powder injection molding) or the like.
  • the housing 223 includes an ultrasonic transmission / reception unit and an optical transmission / reception unit as a transmission / reception unit 221 inside, and a proximal end side is connected to the drive shaft 222.
  • a short coil-shaped elastic member 231 is provided on the tip side.
  • the elastic member 231 is a stainless steel wire formed in a coil shape, and the elastic member 231 is disposed on the distal end side, thereby preventing the imaging core 220 from being caught in the catheter sheath 201 when moving the imaging core 220 back and forth.
  • 232 is a reinforcing coil, which is provided for the purpose of preventing a sharp bending of the distal end portion of the catheter sheath 201.
  • the guide wire lumen tube 203 has a guide wire lumen into which a guide wire can be inserted.
  • the guide wire lumen tube 203 is used to receive a guide wire previously inserted into a body cavity such as a blood vessel, and guide the catheter sheath 201 to the affected area using the guide wire.
  • the drive shaft 222 can move the transmission / reception unit 221 in the axial direction and the rotation direction with respect to the catheter sheath 201, is flexible, and has a characteristic capable of transmitting rotation well, for example, from a metal wire such as stainless steel. It is comprised by the multilayer multilayer coil which becomes.
  • 3A is a cross-sectional configuration of the imaging core
  • b and c are diagrams illustrating the arrangement of the ultrasonic transmission / reception unit and the optical transmission / reception unit.
  • positioned in the housing 223 is provided with the ultrasonic transmission / reception part 310 and the optical transmission / reception part 320, and the ultrasonic transmission / reception part 310 and the optical transmission / reception part 320 are respectively Further, the drive shaft 222 is disposed along the axial direction on the rotation center axis (on the one-dot chain line a in FIG. 3).
  • the ultrasonic transmission / reception unit 310 is disposed on the distal end side of the probe unit 101, and the optical transmission / reception unit 320 is disposed on the proximal end side of the probe unit 101, and the ultrasonic transmission / reception position of the ultrasonic transmission / reception unit 310 is It is attached in the housing 223 so that the distance between the optical transmission / reception unit 320 and the optical transmission / reception position becomes L.
  • the ultrasonic transmission / reception unit 310 and the optical transmission / reception unit 320 include an ultrasonic transmission direction (elevation angle direction) of the ultrasonic transmission / reception unit 310 and an optical transmission direction (elevation angle direction) of the optical transmission / reception unit 320 with respect to the axial direction of the drive shaft 222.
  • This angle (angle ⁇ ) is not 90 ° but is shifted by 2 to 4 °. The reason is that if the angle is 90 °, a reflected wave and reflected light from the catheter sheath 201 are detected.
  • the angle ⁇ may be appropriately set according to the apparatus configuration and the like, and is merely an example, and the present invention is not limited thereby.
  • the ultrasonic transmission / reception unit 310 and the optical transmission / reception unit 320 have a housing so that the angle difference between the transmission direction of the ultrasonic wave and the rotation direction of the optical transmission direction is 0 (but not limited to 0). 223 is mounted.
  • the ultrasonic transmission / reception unit 310 and the optical transmission / reception unit 320 in the transmission / reception unit 221 arranged in the housing 223 are shifted by a relative distance L with respect to the axial direction, and the ultrasonic transmission / reception unit 310 transmits ultrasonic waves.
  • the angle difference between the rotation direction in the direction and the light transmission direction of the optical transceiver 320 is set to zero. Therefore, when reconstructing a vascular tomographic image due to ultrasonic waves and optical interference, there is a deviation of the relative distance L in the axial direction between them, and the deviation of the angle with respect to the rotation axis is zero.
  • One tomogram may be reconstructed to match the other tomogram according to an algorithm that is considered to be present.
  • the axial distance between the ultrasonic transmission / reception unit 310 and the optical transmission / reception unit 320 in the actually manufactured transmission / reception unit 310 may be longer or shorter than L.
  • the ultrasonic transmission / reception unit 310 and the optical transmission / reception unit 320 are attached with a shift of ⁇ instead of 0 when the rotation direction of the optical transmission direction is used as a reference. There is also.
  • the wider the range of tolerance in the manufacturing stage the better the yield and the cost problem will be solved.
  • the reliability when comparing the ultrasonic tomographic image and the optical coherent tomographic image from the viewpoint in the same axial direction and the same rotational direction is low.
  • the present invention solves the above problems. For this reason, in the embodiment, the following was dealt with.
  • First, in the algorithm for reconstructing an ultrasonic tomographic image and an optical coherent tomographic image, the axial distance L between the ultrasonic transmission / reception unit 310 and the optical transmission / reception unit 320 and the transmission direction thereof instead of processing the angle difference ⁇ in the rotation direction between them as fixed, they can be appropriately changed from the outside as “arguments (parameters)”.
  • Second when the actually manufactured housing 223 is inspected, the axial measurement distance L between the ultrasonic transmission / reception unit 310 and the optical transmission / reception unit 320, and the actual measurement angle difference ⁇ between the rotation directions thereof.
  • the RFID chip also referred to as an RFID tag
  • Reference numeral 250 shown in FIG. 2 is the RFID chip.
  • the scanner / pullback unit 102 operates under the control of the main body control unit 111, accesses this RFID chip, and reads the information relating to the distance L and the angle difference ⁇ stored therein.
  • a reader hereinafter, a reading unit
  • the communicable distance by the RFID communication technology is at least several centimeters, the distance between the RFID chip and the RFID reading unit when the probe 101 is set on the scanner / pullback unit 102 should be within that range. That is, high accuracy is not necessary for the installation position of the reading unit installed in the scanner / pullback unit 102.
  • ⁇ + m ⁇ a variety of RFID chips in which information indicated by the combination is already written are prepared in advance, and one of the values obtained from the inspection is selected, and the probe 101 is preset. Attach to the position. Such a procedure can be expected to reduce costs and manufacturing time.
  • the examples other than the above are examples, and the present invention is not limited thereby.
  • the scanning start timing for obtaining the vascular tomographic image or an appropriate timing before that (for example, when the probe 101 is fixed to the scanner / pullback unit 102), the probe 101
  • the RFID reader attached to the vicinity connected to the scanner / pullback unit 102 is read by the RFID reading unit, the read distance L and the angle difference ⁇ are determined, and processing relating to tomographic image reconstruction using them as arguments Therefore, an ultrasonic tomographic image and an optical coherent tomographic image are reconstructed.
  • FIG. 4 is a diagram illustrating a functional configuration of the diagnostic imaging apparatus 100 that combines the function of IVUS and the function of OCT (here, wavelength sweep type OCT). Note that the diagnostic imaging apparatus combining the IVUS function and the other OCT functions also has the same functional configuration, and thus the description thereof is omitted here.
  • OCT wavelength sweep type OCT
  • a scanner / pullback unit 102 is provided with a reading unit 570 that accesses the RFID chip 250 attached to the probe 101 and reads stored information.
  • the reading unit 570 is connected to the signal processing unit 528 in the operation control device 103.
  • the imaging core 220 includes an ultrasonic transmission / reception unit 310 inside the tip, and the ultrasonic transmission / reception unit 310 transmits ultrasonic waves based on the pulse wave transmitted from the ultrasonic signal transmitter / receiver 552.
  • the reflected wave echo
  • the ultrasonic signal transmitter / receiver 552 is received and transmitted to the ultrasonic signal transmitter / receiver 552 as an ultrasonic echo via the adapter 502 and the slip ring 551.
  • the rotational drive unit side of the slip ring 551 is rotationally driven by a radial scanning motor 505 of the rotational drive unit 504. Further, the rotation angle of the radial scanning motor 505 is detected by the encoder unit 506. Further, the scanner / pullback unit 102 includes a linear drive device 507, and defines the axial operation of the imaging core 220 based on a signal from the signal processing unit 528.
  • the ultrasonic signal transmitter / receiver 552 includes a transmission wave circuit and a reception wave circuit (not shown).
  • the transmission wave circuit transmits a pulse wave to the ultrasonic transmission / reception unit 310 in the imaging core 220 based on the control signal transmitted from the signal processing unit 528.
  • the reception wave circuit receives an ultrasonic signal from the ultrasonic transmission / reception unit 310 in the imaging core 220.
  • the received ultrasonic signal is amplified by the amplifier 553 and then input to the detector 554 for detection.
  • the A / D converter 555 samples the ultrasonic signal output from the detector 554 for 200 points at 30.6 MHz, and outputs digital data of one line (line extending from the rotation center position onto the radiation) (super Sound wave data).
  • 30.6 MHz is assumed, but this is calculated on the assumption that 200 points are sampled at a depth of 5 mm when the sound speed is 1530 m / sec. Therefore, the sampling frequency is not particularly limited to this.
  • the line-unit ultrasonic data generated by the A / D converter 555 is input to the signal processing unit 528.
  • the signal processing unit 528 converts the ultrasonic data to gray scale to form an ultrasonic tomographic image at each position in the body cavity such as a blood vessel, and outputs it to the LCD monitor 113 at a predetermined frame rate.
  • the signal processing unit 528 is connected to the motor control circuit 529 and receives the video synchronization signal of the motor control circuit 529.
  • the signal processing unit 528 constructs an ultrasonic tomographic image in synchronization with the received video synchronization signal.
  • the video synchronization signal of the motor control circuit 529 is also sent to the rotation drive device 504, and the rotation drive device 504 outputs a drive signal synchronized with the video synchronization signal.
  • Wavelength Sweep OCT 508 is a wavelength swept light source (Swept Laser), which is an extended-cavity comprising an optical fiber 516 and a polygon scanning filter (508b) coupled in a ring shape with an SOA 515 (semiconductor optical amplifier). It is a kind of Laser.
  • Spept Laser wavelength swept light source
  • SOA 515 semiconductor optical amplifier
  • the light output from the SOA 515 travels through the optical fiber 516 and enters the polygon scanning filter 508b, where the light whose wavelength is selected is amplified by the SOA 515 and finally output from the coupler 514.
  • a wavelength is selected by a combination of a diffraction grating 512 that separates light and a polygon mirror 509.
  • the light dispersed by the diffraction grating 512 is condensed on the surface of the polygon mirror 509 by two lenses (510, 511).
  • only light having a wavelength orthogonal to the polygon mirror 509 returns through the same optical path and is output from the polygon scanning filter 508b. That is, by rotating the polygon mirror 509, time sweeping of the wavelength can be performed.
  • the polygon mirror 509 for example, a 32-hedron mirror is used, and the rotation speed is about 50000 rpm.
  • a wavelength sweeping method combining the polygon mirror 509 and the diffraction grating 512 enables high-speed, high-output wavelength sweeping.
  • the light of the wavelength swept light source 508 output from the coupler 514 is incident on one end of the first single mode fiber 540 and transmitted to the distal end side.
  • the first single mode fiber 540 is optically coupled to the second single mode fiber 545, the third single mode fiber 544, and the sixth single mode fiber 546 at an intermediate optical coupler unit 541.
  • An optical rotary joint (optical cup) that transmits light by coupling a non-rotating part (fixed part) and a rotating part (rotational drive part) to the tip side of the optical coupler part 541 of the first single mode fiber 540.
  • a ring portion 503 is provided in the rotary drive device 504.
  • the fifth single mode fiber 543 of the probe unit 101 is detachably connected to the distal end side of the fourth single mode fiber 542 in the optical rotary joint (optical coupling unit) 503 via the adapter 502. Yes.
  • the light from the wavelength swept light source 508 is transmitted to the fifth single mode fiber 543 that is inserted into the imaging core 220 and can be driven to rotate.
  • the transmitted light is irradiated from the optical transmission / reception unit 320 of the imaging core 220 to the living tissue in the living body lumen while performing radial scanning. Then, a part of the reflected light scattered on the surface or inside of the living tissue is taken in by the optical transceiver 320 of the imaging core 220 and returns to the sixth single mode fiber 546 side through the reverse optical path. Further, a part of the light is moved to the second single mode fiber 545 side by the optical coupler unit 541 and emitted from one end of the second single mode fiber 545, and then received by a photodetector (eg, a photodiode 524).
  • a photodetector eg, a photodiode 524
  • the rotational drive unit side of the optical rotary joint 503 is rotationally driven by a radial scanning motor 505 of the rotational drive device 504. Further, the rotation angle of the radial scanning motor 505 is detected by the encoder unit 506. Further, the scanner / pullback unit 102 includes a linear drive device 507, and defines the axial operation of the imaging core 220 based on an instruction from the signal processing unit 528.
  • an optical path length variable mechanism 532 for finely adjusting the optical path length of the reference light is provided at the tip of the third single mode fiber 544 opposite to the optical coupler section 541.
  • the optical path length changing mechanism 532 changes the optical path length to change the optical path length corresponding to the variation in length so that the variation in length of each probe unit 101 when the probe unit 101 is replaced and used can be absorbed. Means.
  • the third single mode fiber 544 and the collimating lens 518 are provided on a uniaxial stage 522 that is movable as indicated by an arrow 523 in the direction of the optical axis, and form optical path length changing means.
  • the uniaxial stage 522 when the probe unit 101 is replaced, functions as an optical path length changing unit having a variable range of the optical path length that can absorb variations in the optical path length of the probe unit 101. Further, the uniaxial stage 522 also has a function as an adjusting means for adjusting the offset. For example, even when the tip of the probe unit 101 is not in close contact with the surface of the biological tissue, the optical path length is minutely changed by the uniaxial stage to set the state to interfere with the reflected light from the surface position of the biological tissue. Is possible.
  • the optical path length is finely adjusted by the uniaxial stage 522, and the light reflected by the mirror 521 via the grating 519 and the lens 520 is supplied to the sixth coupler 541 provided in the middle of the third single mode fiber 544.
  • the light obtained from the single mode fiber 546 side is mixed and received by the photodiode 524.
  • the interference light received by the photodiode 524 in this way is photoelectrically converted, amplified by the amplifier 525, and then input to the demodulator 526.
  • the demodulator 526 performs demodulation processing for extracting only the signal portion of the interfered light, and its output is input to the A / D converter 527 as an interference light signal.
  • the A / D converter 527 samples the interference light signal for 2048 points at 180 MHz, for example, and generates one line of digital data (interference light data).
  • the sampling frequency of 180 MHz is based on the assumption that about 90% of the wavelength sweep cycle (12.5 ⁇ sec) is extracted as 2048 digital data when the wavelength sweep repetition frequency is 40 kHz.
  • the present invention is not limited to this.
  • the line-by-line interference light data generated by the A / D converter 527 is input to the signal processing unit 528.
  • the signal processing unit 528 frequency-decomposes interference light data by FFT (Fast Fourier Transform) to generate data in the depth direction (line data), and coordinate-converts this to obtain a body cavity such as a blood vessel.
  • FFT Fast Fourier Transform
  • An optical tomographic image at each position is constructed and output to the LCD monitor 113 at a predetermined frame rate.
  • the signal processing unit 528 is further connected to the optical path length adjusting means control device 530.
  • the signal processing unit 528 controls the position of the uniaxial stage 522 via the optical path length adjusting unit controller 530.
  • FIG. 5 is a diagram showing a functional configuration and related functional blocks for realizing a construction process in the signal processing unit 528 of the diagnostic imaging apparatus 100.
  • the control unit 605 controls the reading unit 570, controls the reading unit 570 of the scanner / pullback unit 102, the inter-sensor distance L stored in the RFID chip provided in the probe unit 101, and
  • the angle difference ⁇ in the transmission direction of the rotation direction of the sensor is read and set as a parameter in one of the ultrasonic tomographic constructing unit 613 and the optical tomographic image constructing unit 603. For example, if the tomographic image constructed by the optical tomographic image constructing unit 603 is used as a reference, the tomographic image to be generated is shifted in the axial direction by L with respect to the ultrasonic tomographic image 613, and ⁇ is based on the axis of the blood vessel. Set to create a rotated tomogram.
  • the interference light data 621 generated by the A / D converter 527 is output from the motor control circuit 529 to the encoder of the radial scanning motor 505 in the line data generation unit 601 in the signal processing unit 528.
  • processing is performed so that the number of lines per rotation of the radial scanning is 512.
  • an optical tomographic image is constructed from 512 lines, but the number of lines is not limited to this.
  • the line data 622 output from the line data generation unit 601 is stored in the line data memory 602 for each rotation of the radial scan based on an instruction from the control unit 605.
  • the control unit 605 counts the pulse signal 641 output from the movement amount detector of the linear driving device 507 and generates each line data 622 when the line data 622 is stored in the line data memory 602. The count value is stored in association with each other.
  • the line data 623 stored in association with the count value is subjected to various processes (line addition averaging process, filter process, etc.) in the optical tomographic image construction unit 603 based on an instruction from the control unit 605, Sequentially output as an optical tomographic image 624.
  • the image processing unit 604 performs image processing for display on the LCD monitor 113 and then outputs the optical tomographic image 625 to the LCD monitor 113.
  • the ultrasonic data 631 generated by the A / D converter 555 is a signal of the encoder unit 506 of the radial scanning motor 505 output from the motor control circuit 529 in the line data generation unit 611 in the signal processing unit 528. Is used so that the number of lines per one rotation of the radial scanning is 512.
  • the line data 632 output from the line data generation unit 611 is stored in the line data memory 612 for each rotation of the radial scan based on an instruction from the control unit 605.
  • the control unit 605 counts the pulse signal 641 output from the movement amount detector of the linear driving device 507 and generates each line data 632 when storing the line data 632 in the line data memory 612.
  • the count value is stored in association with each other.
  • the line data 633 stored in association with the count value is subjected to various processes (line addition averaging process, filter process, etc.) in the ultrasonic tomographic image construction unit 613 based on an instruction from the control unit 605. Then, a shift by the distance L with respect to the axial direction and an R ⁇ -transformed ultrasonic tomographic image 634 are sequentially output to the image processing unit 604.
  • the image processing unit 604 performs image processing for display on the LCD monitor 113, and then outputs the ultrasonic tomographic image 635 to the LCD monitor 113.
  • control unit 605 Based on the above, the processing of the control unit 605 will eventually be performed according to the flowchart shown in FIG.
  • step S101 it is determined whether or not there is a scan instruction. If it is determined that there is a scan instruction, in step S102, the control unit 605 controls the reading unit 570, the inter-sensor distance L stored in the RFID chip of the probe unit 101, and the transmission direction of the rotation direction of each sensor. Is obtained. Thereafter, in step S103, the acquired L and ⁇ are set as parameters in the construction process of the ultrasonic tomographic image and the optical coherent tomographic image. Thereafter, each tomographic image reconstruction process is executed, and a display process is performed.
  • the data obtained by scanning may be reused in the future.
  • a file containing the angle ⁇ in some cases is stored in the external storage device. (Hard disk etc.) can be stored.
  • the ultrasonic wave transmission / reception unit and the light transmission / reception unit in the probe are not required to have high positioning accuracy, and the deviation based on the relative positions of the ultrasonic transmission / reception unit and the light transmission / reception unit is prevented.
  • a corrected ultrasonic tomographic image and optical tomographic image can be generated.
  • the operator is not forced to perform special work.
  • both the distance L between the sensors and the angle difference ⁇ between the sensor rotation direction and the transmission direction are stored in the RFID chip.
  • either one is sufficiently high in terms of cost. If positioning is possible with accuracy and the other is not, the latter value may be stored in the RFID chip.
  • an angle ⁇ may be written on the RFID chip.
  • the angle ⁇ can be taken into account when the angle ⁇ is read, so that a more accurate tomographic image can be created.
  • the ultrasonic transmission / reception unit 310 and the optical transmission / reception unit 320 are arranged along the axial direction on the rotation center axis.
  • a slight deviation from the rotation center position may be allowed.
  • 7A in FIG. 7 shows a state in which the ultrasonic wave transmitting / receiving position in the ultrasonic wave transmitting / receiving unit 310 is shifted by r0 from the rotation axis.
  • FIG. 7 shows a state where the light transmitting / receiving position in the light transmitting / receiving unit 320 is shifted from the rotation axis by r1.
  • 7A and 7B in FIG. 7 should be understood as corresponding to b and c in FIG. 3 shown in the first embodiment. Therefore, the illustrated ⁇ has the same meaning as in the first embodiment.
  • r0 and r1 of the probe obtained by manufacturing are illustrated. Is measured, and an RFID chip storing and holding ⁇ and L together with r0 and r1 may be attached to the probe.
  • step S102 in FIG. 6 not only L and ⁇ but also r0 and r1 are acquired.
  • step S103 tomographic image reconstruction processing may be performed including r0 and r1 in addition to L and ⁇ .
  • the ultrasonic transmission / reception unit 310 and the optical transmission / reception unit 320 are accommodated / fixed in the housing 233, a slight deviation from the rotation center position is allowed. While maintaining the reconstruction of a tomographic image with high accuracy, the yield can be further improved as compared with the first embodiment described above.
  • an RFID chip is shown as an example of the information storage medium.
  • the RFID chip is a desirable form because it can be very small and useful.
  • a two-dimensional barcode including values of L and ⁇ (and ro, r1 if applied to the second embodiment) This seal may be attached to an appropriate position of the probe unit 101.
  • the reading unit 570 reads the barcode.
  • the scan start instruction is given as the timing for reading the information in the RFID chip.
  • the main body control unit 111 is turned on or the scanner / pullback unit 102 is turned on.
  • the timing at which the probe unit 101 is detected may be detected.
  • the processing of the signal processing unit 528 requires some hardware, most of the processing can be realized by an application executed by the control unit 605 in the signal processing unit 528. Therefore, it is obvious that the present invention includes a program for causing a computer to execute and a computer-readable storage medium storing the program.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Endoscopes (AREA)

Abstract

La présente invention permet la génération d'une image tomographique ultrasonore et d'une image tomographique optique entre lesquelles le déplacement basé sur les positions relatives d'une unité d'émission/réception ultrasonore et d'une unité d'émission/réception de lumière dans une sonde est corrigé sans requérir à une précision de positionnement élevée pour l'unité d'émission/réception ultrasonore et l'unité d'émission/réception de lumière. A cette fin, à une partie de sonde (101) ayant une unité d'émission/réception ultrasonore et une unité d'émission/réception de lumière, une puce RFID (250) qui stocke la distance (L) dans la direction d'axe de rotation entre l'unité d'émission/réception ultrasonore et l'unité d'émission/réception de lumière, et la différence angulaire (θ) entre des directions de rotation dans la direction d'émission ultrasonore et la direction d'émission de lumière est attachée. Une unité de traitement de signal (528) d'un dispositif de commande de fonctionnement (103) acquiert des informations stockées dans la puce RFID (250) par l'intermédiaire d'une unité de lecture (570), et construit et affiche une image tomographique ultrasonore et une image tomographique optique qui ont accommodé la distance (L) et la différence angulaire (θ).
PCT/JP2013/002037 2012-03-26 2013-03-26 Dispositif de diagnostic d'image et procédé de commande pour celui-ci WO2013145711A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2014507429A JP6062421B2 (ja) 2012-03-26 2013-03-26 画像診断装置及びその作動方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012069144 2012-03-26
JP2012-069144 2012-03-26

Publications (1)

Publication Number Publication Date
WO2013145711A1 true WO2013145711A1 (fr) 2013-10-03

Family

ID=49259010

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2013/002037 WO2013145711A1 (fr) 2012-03-26 2013-03-26 Dispositif de diagnostic d'image et procédé de commande pour celui-ci

Country Status (2)

Country Link
JP (1) JP6062421B2 (fr)
WO (1) WO2013145711A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015136854A1 (fr) * 2014-03-12 2015-09-17 テルモ株式会社 Dispositif de commande, son procédé de fonctionnement et système de diagnostic associé
WO2015141136A1 (fr) * 2014-03-19 2015-09-24 テルモ株式会社 Ensemble connecteur de conversion et catheter
JPWO2016152624A1 (ja) * 2015-03-24 2018-01-18 テルモ株式会社 画像診断装置及びその作動方法、プログラム及びコンピュータ可読記憶媒体
CN108742709A (zh) * 2017-03-22 2018-11-06 泰尔茂株式会社 图像诊断装置

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004351214A (ja) * 2003-05-29 2004-12-16 Biosense Webster Inc 超音波式カテーテルキャリブレーションシステム
JP2005095624A (ja) * 2003-09-22 2005-04-14 Siemens Ag 医療検査および／または治療システム
JP2007105450A (ja) * 2005-10-12 2007-04-26 Volcano Corp ＲＦＩＤカテーテルインテリジェンス（ｃａｔｈｅｔｅｒｉｎｔｅｌｌｉｇｅｎｃｅ）を使用する装置及び方法
JP2010508973A (ja) * 2006-11-08 2010-03-25 ライトラブ イメージング， インコーポレイテッド 光−音響イメージングデバイスおよび方法
JP2010516304A (ja) * 2007-01-19 2010-05-20 サニーブルック・ヘルス・サイエンシズ・センター 超音波と光学を複合した画像手段を有する撮像プローブ
JP2011519689A (ja) * 2008-05-07 2011-07-14 インフラレデックス， インコーポレイテッド 脈管内分析のためのマルチモーダルカテーテルシステム

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004351214A (ja) * 2003-05-29 2004-12-16 Biosense Webster Inc 超音波式カテーテルキャリブレーションシステム
JP2005095624A (ja) * 2003-09-22 2005-04-14 Siemens Ag 医療検査および／または治療システム
JP2007105450A (ja) * 2005-10-12 2007-04-26 Volcano Corp ＲＦＩＤカテーテルインテリジェンス（ｃａｔｈｅｔｅｒｉｎｔｅｌｌｉｇｅｎｃｅ）を使用する装置及び方法
JP2010508973A (ja) * 2006-11-08 2010-03-25 ライトラブ イメージング， インコーポレイテッド 光−音響イメージングデバイスおよび方法
JP2010516304A (ja) * 2007-01-19 2010-05-20 サニーブルック・ヘルス・サイエンシズ・センター 超音波と光学を複合した画像手段を有する撮像プローブ
JP2011519689A (ja) * 2008-05-07 2011-07-14 インフラレデックス， インコーポレイテッド 脈管内分析のためのマルチモーダルカテーテルシステム

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HAO-CHUNG YANG ET AL.: "A Dual-Modality Probe Utilizing Intravascular Ultrasound and Optical Coherence Tomography for Intravascular Imaging Applications", IEEE TRANSACTIONS ON ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL, vol. 57, no. 12, December 2010 (2010-12-01), pages 2839 - 2843, XP011340041, DOI: doi:10.1109/TUFFC.2010.1758 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015136854A1 (fr) * 2014-03-12 2015-09-17 テルモ株式会社 Dispositif de commande, son procédé de fonctionnement et système de diagnostic associé
JPWO2015136854A1 (ja) * 2014-03-12 2017-04-06 テルモ株式会社 制御装置及びその動作方法並びに診断システム
WO2015141136A1 (fr) * 2014-03-19 2015-09-24 テルモ株式会社 Ensemble connecteur de conversion et catheter
JPWO2015141136A1 (ja) * 2014-03-19 2017-04-06 テルモ株式会社 変換コネクタ、及び、カテーテルセット
JPWO2016152624A1 (ja) * 2015-03-24 2018-01-18 テルモ株式会社 画像診断装置及びその作動方法、プログラム及びコンピュータ可読記憶媒体
CN108742709A (zh) * 2017-03-22 2018-11-06 泰尔茂株式会社 图像诊断装置

Also Published As

Publication number Publication date
JPWO2013145711A1 (ja) 2015-12-10
JP6062421B2 (ja) 2017-01-18

Similar Documents

Publication Publication Date Title
JP4838029B2 (ja) 画像診断装置およびその処理方法
JP4768494B2 (ja) 画像診断装置およびその処理方法
JP6117772B2 (ja) プローブ及び画像診断装置
JP4838032B2 (ja) 画像診断装置およびその処理方法
JP6001765B2 (ja) 画像診断装置及びプログラム
JP6031089B2 (ja) プローブ及び画像診断装置
JP5981557B2 (ja) 画像診断装置
JP6055463B2 (ja) 断層画像生成装置および作動方法
WO2014136137A1 (fr) Appareil d'imagerie diagnostique, dispositif de traitement des informations et procédés de commande, programmes et support de stockage lisible par ordinateur associés
JP6125615B2 (ja) 画像診断装置及びプログラム
JP5718819B2 (ja) 画像診断装置及びその制御方法
JP6062421B2 (ja) 画像診断装置及びその作動方法
WO2016152624A1 (fr) Appareil de diagnostic d'image, son procédé de commande, programme, et support de stockage lisible par ordinateur
JP5913607B2 (ja) 校正冶具、画像診断装置及び画像診断装置の校正方法
WO2014049641A1 (fr) Dispositif d'imagerie diagnostique, dispositif de traitement de l'information, et procédé de commande de dispositif d'imagerie diagnostique et de dispositif de traitement de l'information

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13768723

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2014507429

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 13768723

Country of ref document: EP

Kind code of ref document: A1