WO2013141187A1 - Dispositif d'injection de médicament - Google Patents

Dispositif d'injection de médicament Download PDF

Info

Publication number
WO2013141187A1
WO2013141187A1 PCT/JP2013/057589 JP2013057589W WO2013141187A1 WO 2013141187 A1 WO2013141187 A1 WO 2013141187A1 JP 2013057589 W JP2013057589 W JP 2013057589W WO 2013141187 A1 WO2013141187 A1 WO 2013141187A1
Authority
WO
WIPO (PCT)
Prior art keywords
cylindrical body
cover member
injection device
drug injection
drug
Prior art date
Application number
PCT/JP2013/057589
Other languages
English (en)
Japanese (ja)
Inventor
早川浩一
照屋雅和
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Publication of WO2013141187A1 publication Critical patent/WO2013141187A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/8802—Equipment for handling bone cement or other fluid fillers
    • A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
    • A61B17/8819—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it characterised by the introducer proximal part, e.g. cannula handle, or by parts which are inserted inside each other, e.g. stylet and cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/8802—Equipment for handling bone cement or other fluid fillers
    • A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
    • A61B17/8822—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it characterised by means facilitating expulsion of fluid from the introducer, e.g. a screw pump plunger, hydraulic force transmissions, application of vibrations or a vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/8802—Equipment for handling bone cement or other fluid fillers
    • A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
    • A61B17/8825—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it characterised by syringe details

Definitions

  • the present invention relates to a drug injection device used for discharging a drug when the drug is injected into an injection space.
  • PVP percutaneous vertebroplasty
  • a filler that hardens with time is injected through a bone biopsy needle inserted into a fractured vertebral body for a vertebral body compression fracture caused by osteoporosis or cancer.
  • the filler for example, calcium phosphate bone cement or polymethylmethacrylate bone cement (hereinafter, also simply referred to as “bone cement”) having X-ray contrast properties is used.
  • bone cement has a very high viscosity, and the pressure loss due to the sponge is very large in the vertebra filled with the bone cement, so it is necessary to inject a small amount at a high pressure of 3 MPa or more at the time of injection. .
  • an injection puncture needle for puncturing bone and a drug injection device connected to the injection puncture needle directly or via a tube are used.
  • the drug injection device generally includes a cylindrical body having a discharge port at the tip and a pusher inserted into the cylindrical body. It is comprised so that the filled bone cement may be discharged from the discharge port provided in the front-end
  • the viscosity of bone cement is high, when performing the operation to advance the pusher to discharge the bone cement filled inside from the drug injecting device, the operator must The outer periphery is often gripped with fingers. In this case, when the body temperature is transmitted from the operator's finger through the tubular body to the bone cement filled in the tubular body, the viscosity of the thermosetting bone cement increases, and thus the pusher is required to advance. The operating force increases.
  • JP-T-2008-541945 For the purpose of maintaining the temperature of the contrast medium or the like filled in the syringe (preventing temperature drop), a configuration in which the outer periphery of the syringe is covered with a jacket is disclosed in JP-T-2008-541945, but JP-T-2008-541945 The configuration is aimed at suppressing the temperature drop by increasing the heat capacity of the container containing the medicine, and about suppressing the heat due to the body temperature of the operator's finger from being transmitted to the medicine. No consideration is given.
  • the filling of the bone cement into the cylindrical body is performed by, for example, an operator holding the cylindrical body with the base end opening facing upward, and the operator or another operator can use the cylindrical body. This is done by pouring bone cement into the body.
  • the prior art has not proposed a technique for making such filling work easier.
  • the present invention has been made in consideration of such problems, can suppress the transfer of the body temperature of the operator's fingers to the medicine in the cylindrical body, and can easily fill the cylindrical body with the medicine.
  • An object is to provide a drug injection device that can be performed.
  • the present invention is a drug injection device that discharges a drug filled inside, and has a drug discharge port provided at a distal end and an opening provided at a proximal end, A cylindrical body filled with the medicine, a pusher that is liquid-tightly inserted into the hollow portion of the cylindrical body and movable in the axial direction in the cylindrical body, and an operator's A cover member that covers the periphery of the cylindrical body in order to prevent body temperature from being transmitted to the medicine in the cylindrical body via fingers, the cover member facing the opening upward It is configured to be able to support the cylindrical body in a state where it is in a closed state.
  • the cover member since the periphery of the cylindrical body is covered with the cover member, it is possible to suppress body temperature from being transmitted to the drug in the cylindrical body via the operator's fingers during operation. The For this reason, the influence by heat being transmitted to a chemical
  • a gap along the circumferential direction of the cylindrical body may be formed between the cover member and the cylindrical body.
  • the gap formed between the cover member and the cylindrical body functions as a heat insulating layer, the transfer of heat from the user to the medicine in the cylindrical body can be effectively reduced.
  • the cover member includes a fitting portion that is fitted to an outer peripheral portion of the cylindrical body, and an enlarged-diameter portion having an inner diameter larger than an inner diameter of the fitting portion, and the cover An annular gap extending in the axial direction is formed between the inner peripheral surface of the enlarged diameter portion of the cover member and the outer peripheral surface of the cylindrical body in a state where the cylindrical body is inserted through the member. May be.
  • the cover member is axially displaceable with respect to the tubular body, and the cover member is displaced in the most proximal direction with respect to the tubular body. It is preferable that the tip of the body protrudes from the tip of the cover member.
  • the tip of the cylindrical body can be protruded from the cover member after the cylindrical body is filled with the drug, another member (a puncture needle or a tube for drug insertion) is connected to the cylindrical body. It's easy to do.
  • a guide member that is detachable from the cover member and that is inserted into the pusher in a screwed state is provided, and the guide member is connected to the cover member.
  • the cylindrical body and the cover member may be fixed so as not to be relatively displaceable in the axial direction.
  • the drug injection tool can be stably held when using the drug injection tool, and the operability is excellent.
  • the guide member has not only a function of guiding the movement of the pusher relative to the cylindrical body, but also a function of mutually fixing the cylindrical body and the cover member, the guide means and the connecting means are separated by separate parts. There is no need to configure, and the drug injection device can be configured simply.
  • a flange portion may be provided at the proximal end of the cylindrical body, and the flange portion may be sandwiched between the cover member and the guide member in the axial direction.
  • the cylindrical body and the cover member can be firmly fixed in a state where relative movement in the axial direction is prevented.
  • a rotation preventing means for preventing relative rotation in the circumferential direction of the cylindrical body and the cover member may be provided.
  • the cylindrical body can be prevented from being rotated even when the pusher is rotated.
  • the medicine injection device of the present invention it is possible to suppress the body temperature of the operator's finger from being transmitted to the medicine in the cylindrical body, and it is possible to easily perform the filling operation of the medicine into the cylindrical body.
  • FIG. 3A is a longitudinal cross-sectional view in the assembly state of the chemical injection tool shown in FIG. 3A is a cross-sectional view taken along the line IIIA-IIIA in FIG. 2
  • FIG. 3B is a perspective view showing a structure on the cover member side of the rotation preventing means according to the modification
  • FIG. 3C is a modification.
  • FIG. 4A is a first diagram illustrating a method of filling a cylindrical body with a medicine
  • FIG. 4B is a second diagram illustrating a method of filling a cylindrical body with a medicine
  • FIG. 4A is a first diagram illustrating a method of filling a cylindrical body with a medicine
  • FIG. 4B is a second diagram illustrating a method of filling a cylindrical body with a medicine
  • FIG. 5A is a first diagram illustrating a method for operating a drug injection device
  • FIG. 5B is a second diagram illustrating a method for operating a drug injection device.
  • FIG. 1 is an exploded perspective view showing a drug injection device 10 according to an embodiment of the present invention.
  • FIG. 2 is a longitudinal sectional view of the pharmaceutical injection device 10 shown in FIG. 1 in an assembled state.
  • the drug injection tool 10 is a medical device used for discharging a drug when a drug (filler, injection material) is injected into a desired injection space. For example, bone cement in percutaneous vertebroplasty. Is used to inject into the bone.
  • bone cement such as calcium phosphate bone cement (CPC) or polymethyl methacrylate (PMMA) bone cement
  • CPC calcium phosphate bone cement
  • PMMA polymethyl methacrylate
  • CPC calcium phosphate bone cement
  • alumina ceramics calcium phosphate ceramics and alumina ceramics.
  • Granules made of inorganic materials such as zirconia ceramics and titanium can also be used.
  • the drug injection device 10 includes a cylindrical body 12 filled with a drug, a pusher 14 inserted into the cylindrical body 12, and a cover member that covers the periphery of the cylindrical body 12. 16.
  • the cylindrical body 12 includes a body portion 18 having a lumen (hollow portion) extending in the axial direction, a distal end tube portion 20 protruding from the distal end portion of the body portion 18 toward the distal end side, and a proximal end portion of the body portion 18. And an annular flange portion 22 projecting outward (radially outward) and extending in the circumferential direction.
  • a drug discharge port 12 a is provided at the distal end of the cylindrical body 12, and an opening 12 b is provided at the proximal end of the cylindrical body 12.
  • the opening 12b is referred to as a “base end opening 12b”.
  • the body part 18, the distal end pipe part 20, and the flange part 22 are integrally formed.
  • the body portion 18 includes a parallel portion 18a having a constant inner diameter and a tapered portion 18b that decreases in diameter from the tip of the parallel portion 18a toward the tip tube portion 20, and is formed in a hollow cylindrical shape as a whole.
  • a scale 19 indicating the amount of the medicine is provided on the outer peripheral surface of the body portion 18.
  • the distal end tube portion 20 forms the medicine discharge port 12a and is configured as a luer connector.
  • a lock portion 28 that protrudes in the axial direction from the distal end portion of the body portion 18 concentrically with the distal end tube portion 20 and has an internal thread portion formed on the inner peripheral surface is provided.
  • the medicine is injected by such a distal end pipe part 20 and the lock part 28, it can be connected to an extension tube 80 (see FIG. 5A and the like) or a bone cement injection needle 72 described later.
  • the flange portion 22 in the illustrated example is circular, but may be oval, or may be a shape protruding outward in a partial range in the circumferential direction.
  • a filling chamber 26 for filling a medicine is formed by a space surrounded by the cylindrical body 12 and the pusher 14.
  • the constituent material of the cylindrical body 12 is not particularly limited.
  • polyolefin such as polypropylene, polyethylene, cyclic polyolefin, and polymethylpentene 1 polyester, nylon, polycarbonate, polymethyl methacrylate (PMMA), and polyetherimide (PEI).
  • PEI polyetherimide
  • It may be formed of a resinous material such as polyethersulfone, polyetheretherketone (PEEK), fluororesin, polyphenylene sulfide (PPS), polyacetal resin (POM), a metallic material such as stainless steel, glass or the like.
  • PES polyetheretherketone
  • PPS polyphenylene sulfide
  • POM polyacetal resin
  • metallic material such as stainless steel, glass or the like.
  • the constituent material of the cylindrical body 12 is substantially transparent in order to ensure internal visibility.
  • it is preferable that it has strength, elasticity and chemical resistance that can withstand high pressure.
  • the pusher 14 is inserted into the hollow portion of the cylindrical body 12.
  • a seal member 32 is attached to the head 30 which is the tip of the pusher 14.
  • an annular seal groove 34 extending in the circumferential direction is formed on the outer periphery of the head 30, and a ring-shaped seal member 32 (for example, a silicone O-ring or the like) is disposed in the seal groove 34.
  • a seal member 32 slides in the axial direction while being in close contact with the inner peripheral surface of the cylindrical body 12, so that liquid-tightness can be reliably maintained and slidability can be improved.
  • a gasket made of an elastic resin material may be attached to the tip of the pusher 14.
  • a male screw portion 38 is formed along the axial direction in a certain range on the base end side of the head 30.
  • the outer diameter of the male screw portion 38 is smaller than the inner diameter of the body portion 18 of the cylindrical body 12.
  • a guide member 42 that can be connected to the cover member 16 is attached to the male screw portion 38.
  • a handle 40 (rotation operation portion) having a diameter expanded outward (radially outward) is provided at the proximal end portion of the pusher 14.
  • the handle 40 is a portion that the user grips (pinch) with fingers when rotating the pusher 14 with respect to the cylindrical body 12 about the axis, and is formed in a substantially cylindrical shape in the illustrated example. ing.
  • a plurality of grooves 41 are formed on the outer periphery of the handle 40 at intervals in the circumferential direction so as to prevent slipping when the user grips and rotates.
  • the shape of the handle 40 is not limited to a substantially cylindrical shape, and may be a wing shape that protrudes radially outward from the proximal end portion of the pusher 14 in opposite directions.
  • the constituent material of the pusher 14 can be selected from those exemplified as the constituent material of the cylindrical body 12 described above.
  • the constituent material of the seal member 32 is not particularly limited.
  • the cover member 16 has a cylindrical shape with both ends open, and the cylindrical body 12 can be inserted from the base end side.
  • the front end surface 16a of the cover member 16 is configured so that the cover member 16 can be placed on a horizontal plane in a standing state with the front end surface 16a facing downward (see FIG. 4A).
  • the front end surface 16 a of the cover member 16 is a flat surface perpendicular to the axis of the cover member 16.
  • the cover member 16 In the state where the cover member 16 and the guide member 42 are coupled, the cover member 16 is prevented from moving in the axial direction with respect to the cylindrical body 12. However, in the state where the cover member 16 and the guide member 42 are separated, the cover member 16 is covered. The member 16 can be displaced in the axial direction with respect to the cylindrical body 12.
  • the cover member 16 has a length that can substantially cover the cylindrical body 12.
  • the cover member 16 is positioned closest to the tubular body 12, that is, the tubular body 12 is inserted through the cover member 16 and the guide member 42 and the cover member 16 are connected (see FIG. 2), the tip of the cover member 16 protrudes in the tip direction from the parallel portion 18 a of the cylindrical body 12.
  • the distal end (tip tube portion 20) of the cylindrical body 12 is , Protruding from the tip of the cover member 16.
  • the cover member 16 includes a fitting portion 44 that fits (contacts) with the outer peripheral portion of the inserted tubular body 12, and a diameter-expanded portion 45 that has an inner diameter larger than the inner diameter of the fitting portion 44.
  • the fitting portion 44 is provided only in a predetermined range constituting the base end portion of the cover member 16 and has an inner diameter that is substantially the same as the outer diameter of the cylindrical body 12.
  • the enlarged diameter portion 45 constitutes a portion (a portion other than the proximal end portion) extending from the distal end portion to the vicinity of the proximal end portion in the cover member 16 and has an inner diameter larger than the outer diameter of the cylindrical body 12.
  • an annular gap 48 extending in the axial direction is formed between the inner peripheral surface of the cover member 16 and the outer peripheral surface of the cylindrical body 12. Is done. As will be described later, the gap 48 functions as a heat insulating layer.
  • the protrusion part which protrudes partially is provided in the outer peripheral part of the cylindrical body 12, or the inner peripheral part of the cover member 16, and the outer peripheral part of the cylindrical body 12 and the inner peripheral part of the enlarged diameter part 45 of the cover member 16 May be in partial contact. Even in this case, a gap 48 (air layer) is formed between the outer peripheral portion of the cylindrical body 12 and the inner peripheral portion of the enlarged diameter portion 45.
  • a constituent material of the cover member 16 it can select from what was illustrated as a constituent material of the cylindrical body 12 mentioned above.
  • the cover member 16 itself may be made of a heat insulating material such as foamed polystyrene.
  • the gap 48 may have a mesh structure or a beam structure.
  • a male screw portion 17 that can be screwed into the second female screw portion 54b of the guide member 42 is provided on the outer periphery of the base end portion of the cover member 16 (the outer periphery of the fitting portion 44).
  • the pusher 14 is inserted into the guide member 42 in a screwed state.
  • the guide member 42 includes a base portion 50 through which the first female screw portion 54a is formed, and a screw cylinder 52 that extends from the outer end of the base portion 50 in the distal direction and has a second female screw portion 54b formed on the inner periphery thereof.
  • the first female screw portion 54a can be screwed with the male screw portion 38 provided on the pusher 14.
  • the second female screw portion 54 b can be screwed with the male screw portion 17 provided on the cover member 16.
  • the rotation of the pusher 14 relative to the cylindrical body 12 is performed by the first female screw portion 54 a provided in the guide member 42 and the male screw portion 38 provided in the pusher 14. Accordingly, a feed screw structure 56 (see FIG. 2) for displacing the pusher 14 in the axial direction with respect to the cylindrical body 12 is configured.
  • a feed screw structure 56 for displacing the pusher 14 in the axial direction with respect to the cylindrical body 12 is configured.
  • As a constituent material of the guide member 42 it can select from what was illustrated as a constituent material of the cylindrical body 12 mentioned above.
  • the flange portion 22 of the cylindrical body 12 is configured such that the guide member 42 (the front surface of the base portion 50 of the guide member 42) and the cover member 16 (of the cover member 16). And the base end surface).
  • the guide member 42 is fixed to the cylindrical body 12 so as not to be relatively movable in the axial direction. That is, in the present embodiment, the guide member 42 has not only a function of guiding the movement of the pusher 14 with respect to the cylindrical body 12 but also a function as a connecting means for mutually fixing the cylindrical body 12 and the cover member 16.
  • FIG. 3A is a cross-sectional view taken along line IIIA-IIIA in FIG.
  • a rib-like projection 58 extending in parallel with the axis of the cylindrical body 12 is provided on the outer peripheral portion of the cylindrical body 12.
  • a groove 59 extending in parallel with the axis of the cover member 16 is provided on the inner peripheral portion of the cover member 16.
  • the protrusion 58 and the groove 59 constitute the rotation preventing means 60 for preventing the relative rotation in the circumferential direction between the cylindrical body 12 and the cover member 16.
  • the groove 59 may be provided on the cylindrical body 12 side, and the protrusion 58 may be provided on the cover member 16 side.
  • a rotation prevention means 60a is configured by a protrusion 61 provided on the base end surface of the cover member 16 and a groove 62 provided on the front surface of the flange portion 22 of the cylindrical body 12. With the base end surface of the cover member 16 and the front surface of the flange portion 22 in contact with each other, the protrusion 61 and the groove 62 engage with each other, thereby preventing relative rotation between the cylindrical body 12 and the cover member 16. .
  • the groove 62 may be provided on the base end surface of the cover member 16, and the protrusion 61 may be provided on the front surface of the flange portion 22.
  • a protrusion or groove is provided on the base end surface of the flange portion 22 of the cylindrical body 12, and a groove or protrusion is provided on the front surface of the base portion 50 of the guide member 42.
  • the drug injection device 10 is basically configured as described above, and the operation and effect thereof will be described below.
  • the cover member 16 in a state where the cylindrical body 12 is inserted is placed in an upright state on a horizontal surface (a work table or the like). Then, since the cylindrical body 12 is supported by the cover member 16, the cylindrical body 12 stops with the proximal end opening 12 b facing upward. That is, the cover member 16 functions as a stand that holds the cylindrical body 12 in an upright state.
  • a predetermined amount of bone cement 66 adjusted in advance and placed in the container 65 is poured into the cylindrical body 12 from above the cylindrical body 12 through the proximal end opening 12b.
  • the operator does not need to hold the cylindrical body 12 while pouring the bone cement 66 into the cylindrical body 12. For this reason, the injection
  • the pusher 14 with the guide member 42 attached is inserted into the cylindrical body 12 from the proximal end opening 12b. And the guide member 42 and the cover member 16 are screwed together and fixed to each other.
  • some air exists above the bone cement 66 (between the bone cement 66 and the pusher 14).
  • the air discharge operation work which extracts the air in the cylindrical body 12 is performed.
  • the tip of the medicine injection device 10 is turned upward, and the apparatus waits for a while. Then, the air gradually rises in the bone cement 66, and finally goes out above the bone cement. Then, by rotating the pusher 14 in the circumferential direction with respect to the cylindrical body 12 and moving it forward, the air can be completely discharged from the cylindrical body 12.
  • the tubular body 12 of the drug injection device 10 and the injection port 74 of the bone cement injection needle 72 pierced into the bone 70 to be injected with the bone cement 66 are connected via the extension tube 80.
  • the medicine injection tool 10 can be operated in a state where the hand of the operator (user) is retracted outside the X-ray irradiation region.
  • the bone cement injection needle 72 includes a hollow puncture needle 76 made of, for example, a metal material, and a handle 78 made of, for example, a resin material fixed to the proximal end portion of the puncture needle 76.
  • a hollow puncture needle 76 made of, for example, a metal material
  • a handle 78 made of, for example, a resin material fixed to the proximal end portion of the puncture needle 76.
  • An injection port 74 communicating with the lumen (hollow part) of the puncture needle 76 is provided at the upper part of the handle 78.
  • One end of the extension tube 80 is provided with a connector 82 that is detachably connected to the injection port 74, and the other end of the extension tube 80 is a connector that is detachable from the distal end tube portion 20 and the lock portion 28 of the cylindrical body 12. 84 is provided.
  • the extension tube 80 preferably has a configuration in which a thread such as Kevlar (registered trademark), nylon, polyphenylene sulfide, stainless steel or the like is wound around the flexible tube wall or on the outer surface in a net or coil shape from the viewpoint of pressure resistance.
  • a thread such as Kevlar (registered trademark), nylon, polyphenylene sulfide, stainless steel or the like
  • it may be a multi-layer tube in which chemical resistant polypropylene or fluororesin is disposed only on the inner surface.
  • the length of the extension tube 80 is preferably set to about 200 to 500 mm so that the operator's (user's) hand can be surely retracted outside the X-ray irradiation region. Further, the distal end portion of the extension tube 80 may be angled.
  • the connector 82 provided at one end of the extension tube 80 is connected to the injection port 74 of the handle 78, and the connector 84 provided at the other end of the extension tube 80 is connected to the distal end tube portion of the cylindrical body 12. 20 and the lock portion 28.
  • the bone cement 66 filled in the drug injection device 10 is discharged and injected into the bone 70 under X-ray fluoroscopy.
  • the pusher 14 is moved to the distal end side with respect to the cylindrical body 12 by rotating the pusher 14.
  • the filling chamber 26 is pressurized to a high pressure, and the bone cement 66 moves the distal end pipe portion 20, the extension tube 80 and the bone cement injection needle 72.
  • the bone cement 66 is injected up to the target injection amount by such a rotation operation on the pusher 14.
  • the operator of the drug injection tool 10 holds the cylindrical body 12 with fingers, and the periphery of the cylindrical body 12 is covered with the cover member 16, and the cylindrical body 12, the cover member 16, Since the gap 48 formed between the two functions as a heat insulating layer, it is possible to suppress body temperature from being transmitted to the bone cement 66 in the tubular body 12 through the fingers of the operator during operation. Therefore, the bone cement 66 is suppressed from being heated by the body temperature of the operator, and the increase rate of the viscosity of the bone cement 66 in the cylindrical body 12 can be suppressed.
  • the extension tube 80 is used to avoid exposure to X-rays when injecting the bone cement 66 under fluoroscopy.
  • the bone cement 66 under CT fluoroscopy is used. May be omitted, and the distal end tube portion 20 of the cylindrical body 12 of the drug injector 10 and the injection port 74 of the bone cement injection needle 72 may be directly connected.
  • the body temperature is increased in the cylindrical body 12 through the fingers of the operator during operation. Transmission to the other drug (bone cement 66) is suppressed. For this reason, the influence by heat being transmitted to a chemical
  • the cover member 16 also functions as a stand for standing the cylindrical body 12, the operator can pour the drug from the proximal end opening 12b of the cylindrical body 12 without gripping the cylindrical body 12. Therefore, the filling operation of the medicine can be performed easily.
  • a gap 48 is formed between the cover member 16 and the cylindrical body 12 along the circumferential direction of the cylindrical body 12. Therefore, when the gap 48 functions as a heat insulating layer, heat transfer from the user to the medicine in the cylindrical body 12 can be more effectively reduced.
  • the cover member 16 can be displaced in the axial direction with respect to the tubular body 12, and the cover member 16 is displaced in the most proximal direction with respect to the tubular body 12.
  • the tip of the body 12 protrudes from the tip of the cover member 16.
  • another member such as a bone cement injection needle 72 is provided on the cylindrical body 12. Or it is easy to connect the extension tube 80.
  • the drug injection device 10 includes a guide member 42 that can be attached to and detached from the cylindrical body 12, and the pusher 14 is inserted in a screwed state, and the guide member 42 further includes the cylindrical body 12.
  • the cylindrical body 12 and the cover member 16 are fixed so that they cannot be displaced relative to each other in the axial direction. According to this configuration, by fixing and integrating the cover member 16 with respect to the cylindrical body 12, the drug injection tool 10 can be stably held when using the drug injection tool 10, and the operability is excellent.
  • the guide member 42 has not only a function of guiding the movement of the pusher 14 with respect to the cylindrical body 12 but also a function of mutually fixing the cylindrical body 12 and the cover member 16. It is not necessary to configure the medicine injection device 10 as individual parts, and the drug injection device 10 can be configured simply.
  • the cylindrical body 12 and the cover member 16 are axially disposed. It can be firmly fixed in a state in which relative movement is prevented.
  • the medicine injection device 10 includes the rotation preventing means 60 (60a) that prevents relative rotation of the cylindrical body 12 and the cover member 16 in the circumferential direction, the cover member 16 is gripped (the cover member 16). Even when the pusher 14 is rotated in a state where the rotation of the cylindrical body 12 is prevented, the cylindrical body 12 can be prevented from being rotated. For this reason, the extension tube 80 or the bone cement injection needle 72 connected to the tubular body 12 can be prevented from rotating with the rotation of the pusher 14, and the procedure is not hindered.
  • the “screw-in type” in which the pusher 14 is moved forward by rotating the pusher 14 with respect to the tubular body 12 is employed.
  • the present invention is not limited to this, and the tubular body.
  • the pusher 14 is slidable in the axial direction with respect to 12, and the pusher 14 is moved forward by pressing the pusher 14 against the cylindrical body 12 without rotating the pusher 14.
  • a “push-in type” may be employed.
  • the coupling structure between the guide member 42 and the cover member 16 is screw fitting.
  • the coupling structure is not limited to this, and other coupling structures, for example, project outward to the base end of the cover member 16.
  • An engagement piece is provided, and a groove portion that can be fitted to the engagement piece is provided in the guide member 42. By the relative rotation of the cover member 16 and the guide member 42, the engagement piece and the groove portion are engaged and disengaged. It is also possible to adopt a structure capable of
  • a configuration in which the guide member 42 is fixed to the cylindrical body 12 by coupling the cover member 16 and the guide member 42 is adopted.
  • a configuration that is fixed to the cylindrical body 12 may be employed.
  • a male screw portion is provided on the outer peripheral portion of the base end of the cylindrical body 12, and the second female screw portion 54b provided on the guide member 42 and the male screw portion are screwed together to form a cylindrical shape.
  • a guide member 42 is fixed to the body 12.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif d'injection de médicament (10) qui comporte : un corps cylindrique (12) dans lequel un médicament est introduit ; un plongeur (14) introduit de manière étanche aux liquides dans une section creuse du corps cylindrique (12) ; un élément de couvercle (16) recouvrant l'entourage du corps cylindrique (12). L'élément de couvercle (16) supprime la transmission de chaleur corporelle, par l'intermédiaire du doigt d'un opérateur, au médicament à l'intérieur du corps cylindrique (12) pendant le fonctionnement du dispositif d'injection de médicament (10). L'élément de couvercle (16) est configuré de façon à pouvoir porter le corps cylindrique (12) de telle sorte qu'une ouverture d'extrémité de base (12b) du corps cylindrique (12) est tournée vers le haut.
PCT/JP2013/057589 2012-03-22 2013-03-18 Dispositif d'injection de médicament WO2013141187A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012-065259 2012-03-22
JP2012065259 2012-03-22

Publications (1)

Publication Number Publication Date
WO2013141187A1 true WO2013141187A1 (fr) 2013-09-26

Family

ID=49222644

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2013/057589 WO2013141187A1 (fr) 2012-03-22 2013-03-18 Dispositif d'injection de médicament

Country Status (1)

Country Link
WO (1) WO2013141187A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017029716A1 (fr) * 2015-08-19 2017-02-23 佐藤製薬株式会社 Seringue pour injection au tympan
JP2018011957A (ja) * 2016-07-21 2018-01-25 ヘレウス メディカル ゲーエムベーハー 圧力リリーフのための三方弁を有する骨セメントアプリケータ

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007216009A (ja) * 2006-01-30 2007-08-30 Howmedica Internatl S De Rl 注射器及びスタンド
JP2008541945A (ja) * 2005-05-31 2008-11-27 マリンクロッド・インコーポレイテッド シリンジの熱保持器及びその使用方法
JP4257976B2 (ja) * 2001-08-20 2009-04-30 シンセス ゲーエムベーハー 骨代替材料の送達用ねじ付きシリンジ
WO2010128855A2 (fr) * 2009-05-04 2010-11-11 Mahayana Holding B.V. Réceptacle pour matériau liquide devant alimenter un corps, ledit réceptacle pouvant être chauffé par réaction exothermique
JP2011213415A (ja) * 2010-03-18 2011-10-27 Tokuyama Dental Corp ノック式吐出容器
US8096975B2 (en) * 2007-05-29 2012-01-17 Lewis Van L Injector and thermal jacket for use with same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4257976B2 (ja) * 2001-08-20 2009-04-30 シンセス ゲーエムベーハー 骨代替材料の送達用ねじ付きシリンジ
JP2008541945A (ja) * 2005-05-31 2008-11-27 マリンクロッド・インコーポレイテッド シリンジの熱保持器及びその使用方法
JP2007216009A (ja) * 2006-01-30 2007-08-30 Howmedica Internatl S De Rl 注射器及びスタンド
US8096975B2 (en) * 2007-05-29 2012-01-17 Lewis Van L Injector and thermal jacket for use with same
WO2010128855A2 (fr) * 2009-05-04 2010-11-11 Mahayana Holding B.V. Réceptacle pour matériau liquide devant alimenter un corps, ledit réceptacle pouvant être chauffé par réaction exothermique
JP2011213415A (ja) * 2010-03-18 2011-10-27 Tokuyama Dental Corp ノック式吐出容器

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017029716A1 (fr) * 2015-08-19 2017-02-23 佐藤製薬株式会社 Seringue pour injection au tympan
JP6113935B1 (ja) * 2015-08-19 2017-04-12 佐藤製薬株式会社 鼓室注入用注射器
EP3338837A4 (fr) * 2015-08-19 2018-08-22 Sato Pharmaceutical Co., Ltd. Seringue pour injection au tympan
JP2018011957A (ja) * 2016-07-21 2018-01-25 ヘレウス メディカル ゲーエムベーハー 圧力リリーフのための三方弁を有する骨セメントアプリケータ

Similar Documents

Publication Publication Date Title
RU2718291C2 (ru) Шприц с подворачивающейся мембраной
US6916308B2 (en) High pressure injection syringe
CA2413665C (fr) Appareil de distribution de pate de pansement multifonctions et trousse pour un tel appareil
US8608707B2 (en) Autoinjector with rotatable deshielder for axially displacing a needle shield
US20120330229A1 (en) Syringe-like mixing device having a distally operable mixing element
JP5385074B2 (ja) 薬剤注入具
NO132921B (fr)
US20200164324A1 (en) A storage, mixing and dispensing device
WO2012066905A1 (fr) Dispositif d'injection de médicament
JP6981976B2 (ja) シリンジ
KR20140037035A (ko) 뼈 시멘트를 위한 유압식 주입 시스템
US20180001033A1 (en) An Injection Needle Assembly for an Injection Device and an Injection Device Comprising Such Assembly
US10994071B2 (en) Syringe adapter with concentric rings
JP6023185B2 (ja) 薬剤注入具
WO2013141187A1 (fr) Dispositif d'injection de médicament
JP2015066070A (ja) 薬剤注入具
US9408975B2 (en) Apparatus for operating syringe piston
WO2013141188A1 (fr) Dispositif d'injection de médicament
US10420892B2 (en) Drive mechanism for a medicament delivery device
JP2014057780A (ja) 薬剤注入具
US11679002B2 (en) Bone graft material loading assembly and associated devices, systems, and methods
US9314288B2 (en) Dispensing device for bone cement
WO2023073636A1 (fr) Système de mesure d'ic-ecg

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13764931

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 13764931

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP