WO2013141187A1

WO2013141187A1 - Drug injection device

Info

Publication number: WO2013141187A1
Application number: PCT/JP2013/057589
Authority: WO
Inventors: 早川浩一; 照屋雅和
Original assignee: テルモ株式会社
Priority date: 2012-03-22
Filing date: 2013-03-18
Publication date: 2013-09-26

Abstract

A drug injection device (10), comprising: a cylindrical body (12) into which a drug is filled; a plunger (14) inserted in a liquid-tight manner into a hollow section of the cylindrical body (12); and a cover member (16) covering the surrounds of the cylindrical body (12). The cover member (16) suppresses the transmission of body heat, via the finger of an operator, to the drug inside the cylindrical body (12) during operation of the drug injection device (10). The cover member (16) is configured so as to be capable of supporting the cylindrical body (12) such that a base end opening (12b) of the cylindrical body (12) is facing upward.

Description

Drug infusion tool

The present invention relates to a drug injection device used for discharging a drug when the drug is injected into an injection space.

In recent years, percutaneous vertebroplasty (PVP) in which a filler that hardens with time is injected through a bone biopsy needle inserted into a fractured vertebral body for a vertebral body compression fracture caused by osteoporosis or cancer. As the filler, for example, calcium phosphate bone cement or polymethylmethacrylate bone cement (hereinafter, also simply referred to as “bone cement”) having X-ray contrast properties is used. Normally, bone cement has a very high viscosity, and the pressure loss due to the sponge is very large in the vertebra filled with the bone cement, so it is necessary to inject a small amount at a high pressure of 3 MPa or more at the time of injection. .

In order to inject bone cement into bone, an injection puncture needle for puncturing bone and a drug injection device connected to the injection puncture needle directly or via a tube are used. The drug injection device generally includes a cylindrical body having a discharge port at the tip and a pusher inserted into the cylindrical body. It is comprised so that the filled bone cement may be discharged from the discharge port provided in the front-end | tip of a cylindrical body (for example, refer patent 4257976).

Since the viscosity of bone cement is high, when performing the operation to advance the pusher to discharge the bone cement filled inside from the drug injecting device, the operator must The outer periphery is often gripped with fingers. In this case, when the body temperature is transmitted from the operator's finger through the tubular body to the bone cement filled in the tubular body, the viscosity of the thermosetting bone cement increases, and thus the pusher is required to advance. The operating force increases. For the purpose of maintaining the temperature of the contrast medium or the like filled in the syringe (preventing temperature drop), a configuration in which the outer periphery of the syringe is covered with a jacket is disclosed in JP-T-2008-541945, but JP-T-2008-541945 The configuration is aimed at suppressing the temperature drop by increasing the heat capacity of the container containing the medicine, and about suppressing the heat due to the body temperature of the operator's finger from being transmitted to the medicine. No consideration is given.

By the way, the filling of the bone cement into the cylindrical body is performed by, for example, an operator holding the cylindrical body with the base end opening facing upward, and the operator or another operator can use the cylindrical body. This is done by pouring bone cement into the body. The prior art has not proposed a technique for making such filling work easier.

The present invention has been made in consideration of such problems, can suppress the transfer of the body temperature of the operator's fingers to the medicine in the cylindrical body, and can easily fill the cylindrical body with the medicine. An object is to provide a drug injection device that can be performed.

In order to achieve the above object, the present invention is a drug injection device that discharges a drug filled inside, and has a drug discharge port provided at a distal end and an opening provided at a proximal end, A cylindrical body filled with the medicine, a pusher that is liquid-tightly inserted into the hollow portion of the cylindrical body and movable in the axial direction in the cylindrical body, and an operator's A cover member that covers the periphery of the cylindrical body in order to prevent body temperature from being transmitted to the medicine in the cylindrical body via fingers, the cover member facing the opening upward It is configured to be able to support the cylindrical body in a state where it is in a closed state.

According to the drug injection device configured as described above, since the periphery of the cylindrical body is covered with the cover member, it is possible to suppress body temperature from being transmitted to the drug in the cylindrical body via the operator's fingers during operation. The For this reason, the influence by heat being transmitted to a chemical | medical agent can be reduced. Further, since the cover member also functions as a stand for standing the cylindrical body, it is not necessary for the operator to grip the cylindrical body when pouring the medicine from the proximal end opening of the cylindrical body. Therefore, the filling operation of the medicine can be performed easily.

In the above-described drug injecting device, a gap along the circumferential direction of the cylindrical body may be formed between the cover member and the cylindrical body.

Since the gap formed between the cover member and the cylindrical body functions as a heat insulating layer, the transfer of heat from the user to the medicine in the cylindrical body can be effectively reduced.

In the above-described drug injection device, the cover member includes a fitting portion that is fitted to an outer peripheral portion of the cylindrical body, and an enlarged-diameter portion having an inner diameter larger than an inner diameter of the fitting portion, and the cover An annular gap extending in the axial direction is formed between the inner peripheral surface of the enlarged diameter portion of the cover member and the outer peripheral surface of the cylindrical body in a state where the cylindrical body is inserted through the member. May be.

In the medicine injection tool, the cover member is axially displaceable with respect to the tubular body, and the cover member is displaced in the most proximal direction with respect to the tubular body. It is preferable that the tip of the body protrudes from the tip of the cover member.

According to the above configuration, since the tip of the cylindrical body can be protruded from the cover member after the cylindrical body is filled with the drug, another member (a puncture needle or a tube for drug insertion) is connected to the cylindrical body. It's easy to do.

In the above-described drug injecting device, a guide member that is detachable from the cover member and that is inserted into the pusher in a screwed state is provided, and the guide member is connected to the cover member. The cylindrical body and the cover member may be fixed so as not to be relatively displaceable in the axial direction.

According to the above configuration, by fixing and integrating the cover member with respect to the cylindrical body, the drug injection tool can be stably held when using the drug injection tool, and the operability is excellent. In addition, since the guide member has not only a function of guiding the movement of the pusher relative to the cylindrical body, but also a function of mutually fixing the cylindrical body and the cover member, the guide means and the connecting means are separated by separate parts. There is no need to configure, and the drug injection device can be configured simply.

In the above-described drug injection device, a flange portion may be provided at the proximal end of the cylindrical body, and the flange portion may be sandwiched between the cover member and the guide member in the axial direction.

According to the above configuration, the cylindrical body and the cover member can be firmly fixed in a state where relative movement in the axial direction is prevented.

In the above-described drug injection device, a rotation preventing means for preventing relative rotation in the circumferential direction of the cylindrical body and the cover member may be provided.

According to the above configuration, the cylindrical body can be prevented from being rotated even when the pusher is rotated.

According to the medicine injection device of the present invention, it is possible to suppress the body temperature of the operator's finger from being transmitted to the medicine in the cylindrical body, and it is possible to easily perform the filling operation of the medicine into the cylindrical body.

It is a disassembled perspective view of the chemical injection device concerning one embodiment of the present invention. It is a longitudinal cross-sectional view in the assembly state of the chemical injection tool shown in FIG. 3A is a cross-sectional view taken along the line IIIA-IIIA in FIG. 2, FIG. 3B is a perspective view showing a structure on the cover member side of the rotation preventing means according to the modification, and FIG. 3C is a modification. It is a perspective view which shows the structure by the side of the cylindrical body of the rotation prevention means which concerns on. 4A is a first diagram illustrating a method of filling a cylindrical body with a medicine, FIG. 4B is a second diagram illustrating a method of filling a cylindrical body with a medicine, and FIG. It is the 3rd figure explaining the filling method of the medicine to a cylindrical body, and Drawing 4D is the 4th figure explaining the filling method of the medicine to a cylindrical body. FIG. 5A is a first diagram illustrating a method for operating a drug injection device, and FIG. 5B is a second diagram illustrating a method for operating a drug injection device.

Hereinafter, preferred embodiments of the pharmaceutical injection device 10 according to the present invention will be described with reference to the accompanying drawings.

FIG. 1 is an exploded perspective view showing a drug injection device 10 according to an embodiment of the present invention. FIG. 2 is a longitudinal sectional view of the pharmaceutical injection device 10 shown in FIG. 1 in an assembled state. The drug injection tool 10 is a medical device used for discharging a drug when a drug (filler, injection material) is injected into a desired injection space. For example, bone cement in percutaneous vertebroplasty. Is used to inject into the bone.

As the medicine filled in the medicine injection tool 10, for example, bone cement such as calcium phosphate bone cement (CPC) or polymethyl methacrylate (PMMA) bone cement can be used, and further, calcium phosphate ceramics and alumina ceramics. Granules made of inorganic materials such as zirconia ceramics and titanium can also be used.

As shown in FIGS. 1 and 2, the drug injection device 10 includes a cylindrical body 12 filled with a drug, a pusher 14 inserted into the cylindrical body 12, and a cover member that covers the periphery of the cylindrical body 12. 16.

The cylindrical body 12 includes a body portion 18 having a lumen (hollow portion) extending in the axial direction, a distal end tube portion 20 protruding from the distal end portion of the body portion 18 toward the distal end side, and a proximal end portion of the body portion 18. And an annular flange portion 22 projecting outward (radially outward) and extending in the circumferential direction. A drug discharge port 12 a is provided at the distal end of the cylindrical body 12, and an opening 12 b is provided at the proximal end of the cylindrical body 12. Hereinafter, the opening 12b is referred to as a “base end opening 12b”. The body part 18, the distal end pipe part 20, and the flange part 22 are integrally formed.

The body portion 18 includes a parallel portion 18a having a constant inner diameter and a tapered portion 18b that decreases in diameter from the tip of the parallel portion 18a toward the tip tube portion 20, and is formed in a hollow cylindrical shape as a whole. A scale 19 indicating the amount of the medicine is provided on the outer peripheral surface of the body portion 18.

The distal end tube portion 20 forms the medicine discharge port 12a and is configured as a luer connector. On the outer side of the distal end tube portion 20, a lock portion 28 that protrudes in the axial direction from the distal end portion of the body portion 18 concentrically with the distal end tube portion 20 and has an internal thread portion formed on the inner peripheral surface is provided. When the medicine is injected by such a distal end pipe part 20 and the lock part 28, it can be connected to an extension tube 80 (see FIG. 5A and the like) or a bone cement injection needle 72 described later.

The flange portion 22 in the illustrated example is circular, but may be oval, or may be a shape protruding outward in a partial range in the circumferential direction.

In the cylindrical body 12 configured as described above, a filling chamber 26 (see FIG. 2) for filling a medicine is formed by a space surrounded by the cylindrical body 12 and the pusher 14.

The constituent material of the cylindrical body 12 is not particularly limited. For example, polyolefin such as polypropylene, polyethylene, cyclic polyolefin, and polymethylpentene 1, polyester, nylon, polycarbonate, polymethyl methacrylate (PMMA), and polyetherimide (PEI). It may be formed of a resinous material such as polyethersulfone, polyetheretherketone (PEEK), fluororesin, polyphenylene sulfide (PPS), polyacetal resin (POM), a metallic material such as stainless steel, glass or the like. . Moreover, it is preferable that the constituent material of the cylindrical body 12 is substantially transparent in order to ensure internal visibility. Moreover, it is preferable that it has strength, elasticity and chemical resistance that can withstand high pressure.

The pusher 14 is inserted into the hollow portion of the cylindrical body 12. A seal member 32 is attached to the head 30 which is the tip of the pusher 14. In the illustrated example, an annular seal groove 34 extending in the circumferential direction is formed on the outer periphery of the head 30, and a ring-shaped seal member 32 (for example, a silicone O-ring or the like) is disposed in the seal groove 34. Such a seal member 32 slides in the axial direction while being in close contact with the inner peripheral surface of the cylindrical body 12, so that liquid-tightness can be reliably maintained and slidability can be improved. Instead of the ring-shaped seal member 32, a gasket made of an elastic resin material may be attached to the tip of the pusher 14.

In the pusher 14, a male screw portion 38 is formed along the axial direction in a certain range on the base end side of the head 30. The outer diameter of the male screw portion 38 is smaller than the inner diameter of the body portion 18 of the cylindrical body 12. A guide member 42 that can be connected to the cover member 16 is attached to the male screw portion 38.

A handle 40 (rotation operation portion) having a diameter expanded outward (radially outward) is provided at the proximal end portion of the pusher 14. The handle 40 is a portion that the user grips (pinch) with fingers when rotating the pusher 14 with respect to the cylindrical body 12 about the axis, and is formed in a substantially cylindrical shape in the illustrated example. ing. A plurality of grooves 41 are formed on the outer periphery of the handle 40 at intervals in the circumferential direction so as to prevent slipping when the user grips and rotates. Note that the shape of the handle 40 is not limited to a substantially cylindrical shape, and may be a wing shape that protrudes radially outward from the proximal end portion of the pusher 14 in opposite directions.

The constituent material of the pusher 14 can be selected from those exemplified as the constituent material of the cylindrical body 12 described above. The constituent material of the seal member 32 is not particularly limited. For example, olefin elastomers, styrene elastomers, polyester elastomers, polyurethane elastomers, vulcanized rubbers such as silicone rubber, butyl rubber, fluororubber, and fluororesin It may be formed of a coated material.

The cover member 16 has a cylindrical shape with both ends open, and the cylindrical body 12 can be inserted from the base end side. The front end surface 16a of the cover member 16 is configured so that the cover member 16 can be placed on a horizontal plane in a standing state with the front end surface 16a facing downward (see FIG. 4A). In the present embodiment, the front end surface 16 a of the cover member 16 is a flat surface perpendicular to the axis of the cover member 16.

In the state where the cover member 16 and the guide member 42 are coupled, the cover member 16 is prevented from moving in the axial direction with respect to the cylindrical body 12. However, in the state where the cover member 16 and the guide member 42 are separated, the cover member 16 is covered. The member 16 can be displaced in the axial direction with respect to the cylindrical body 12.

The cover member 16 has a length that can substantially cover the cylindrical body 12. Preferably, the cover member 16 is positioned closest to the tubular body 12, that is, the tubular body 12 is inserted through the cover member 16 and the guide member 42 and the cover member 16 are connected (see FIG. 2), the tip of the cover member 16 protrudes in the tip direction from the parallel portion 18 a of the cylindrical body 12. In addition, preferably, in a state where the cylindrical body 12 is inserted through the cover member 16 and the guide member 42 and the cover member 16 are connected (the state shown in FIG. 2), the distal end (tip tube portion 20) of the cylindrical body 12 is , Protruding from the tip of the cover member 16.

The cover member 16 includes a fitting portion 44 that fits (contacts) with the outer peripheral portion of the inserted tubular body 12, and a diameter-expanded portion 45 that has an inner diameter larger than the inner diameter of the fitting portion 44. The fitting portion 44 is provided only in a predetermined range constituting the base end portion of the cover member 16 and has an inner diameter that is substantially the same as the outer diameter of the cylindrical body 12. The enlarged diameter portion 45 constitutes a portion (a portion other than the proximal end portion) extending from the distal end portion to the vicinity of the proximal end portion in the cover member 16 and has an inner diameter larger than the outer diameter of the cylindrical body 12. For this reason, when the cylindrical body 12 is inserted through the cover member 16, an annular gap 48 extending in the axial direction is formed between the inner peripheral surface of the cover member 16 and the outer peripheral surface of the cylindrical body 12. Is done. As will be described later, the gap 48 functions as a heat insulating layer.

In addition, the protrusion part which protrudes partially is provided in the outer peripheral part of the cylindrical body 12, or the inner peripheral part of the cover member 16, and the outer peripheral part of the cylindrical body 12 and the inner peripheral part of the enlarged diameter part 45 of the cover member 16 May be in partial contact. Even in this case, a gap 48 (air layer) is formed between the outer peripheral portion of the cylindrical body 12 and the inner peripheral portion of the enlarged diameter portion 45. As a constituent material of the cover member 16, it can select from what was illustrated as a constituent material of the cylindrical body 12 mentioned above. Further, the cover member 16 itself may be made of a heat insulating material such as foamed polystyrene. Further, the gap 48 may have a mesh structure or a beam structure.

A male screw portion 17 that can be screwed into the second female screw portion 54b of the guide member 42 is provided on the outer periphery of the base end portion of the cover member 16 (the outer periphery of the fitting portion 44). The pusher 14 is inserted into the guide member 42 in a screwed state. The guide member 42 includes a base portion 50 through which the first female screw portion 54a is formed, and a screw cylinder 52 that extends from the outer end of the base portion 50 in the distal direction and has a second female screw portion 54b formed on the inner periphery thereof. . The first female screw portion 54a can be screwed with the male screw portion 38 provided on the pusher 14. The second female screw portion 54 b can be screwed with the male screw portion 17 provided on the cover member 16.

In the pharmaceutical injection device 10 according to the present embodiment, the rotation of the pusher 14 relative to the cylindrical body 12 is performed by the first female screw portion 54 a provided in the guide member 42 and the male screw portion 38 provided in the pusher 14. Accordingly, a feed screw structure 56 (see FIG. 2) for displacing the pusher 14 in the axial direction with respect to the cylindrical body 12 is configured. As a constituent material of the guide member 42, it can select from what was illustrated as a constituent material of the cylindrical body 12 mentioned above.

In a state where the guide member 42 and the cover member 16 are connected by screw fitting, the flange portion 22 of the cylindrical body 12 is configured such that the guide member 42 (the front surface of the base portion 50 of the guide member 42) and the cover member 16 (of the cover member 16). And the base end surface). Thereby, the guide member 42 is fixed to the cylindrical body 12 so as not to be relatively movable in the axial direction. That is, in the present embodiment, the guide member 42 has not only a function of guiding the movement of the pusher 14 with respect to the cylindrical body 12 but also a function as a connecting means for mutually fixing the cylindrical body 12 and the cover member 16. Prepare.

FIG. 3A is a cross-sectional view taken along line IIIA-IIIA in FIG. A rib-like projection 58 extending in parallel with the axis of the cylindrical body 12 is provided on the outer peripheral portion of the cylindrical body 12. A groove 59 extending in parallel with the axis of the cover member 16 is provided on the inner peripheral portion of the cover member 16. When the protrusion 58 and the groove 59 are engaged with each other, the relative rotation between the cover member 16 and the cylindrical body 12 is prevented. In this embodiment, two protrusions 58 and two grooves 59 are provided, but one or three or more may be provided.

As described above, in the present embodiment, the protrusion 58 and the groove 59 constitute the rotation preventing means 60 for preventing the relative rotation in the circumferential direction between the cylindrical body 12 and the cover member 16. The groove 59 may be provided on the cylindrical body 12 side, and the protrusion 58 may be provided on the cover member 16 side.

Instead of the rotation prevention means 60, as shown in FIGS. 3B and 3C, a rotation prevention means 60a according to a modification may be provided. The rotation preventing means 60 a is configured by a protrusion 61 provided on the base end surface of the cover member 16 and a groove 62 provided on the front surface of the flange portion 22 of the cylindrical body 12. With the base end surface of the cover member 16 and the front surface of the flange portion 22 in contact with each other, the protrusion 61 and the groove 62 engage with each other, thereby preventing relative rotation between the cylindrical body 12 and the cover member 16. . The groove 62 may be provided on the base end surface of the cover member 16, and the protrusion 61 may be provided on the front surface of the flange portion 22.

As a rotation preventing means according to another modification, a protrusion or groove is provided on the base end surface of the flange portion 22 of the cylindrical body 12, and a groove or protrusion is provided on the front surface of the base portion 50 of the guide member 42. By engaging the protrusion or groove on the side and the groove or protrusion on the base 50 side, relative rotation between the cylindrical body 12 and the cover member 16 may be prevented via the guide member 42.

The drug injection device 10 according to the present embodiment is basically configured as described above, and the operation and effect thereof will be described below.

First, a method for filling the drug injection tool 10 with bone cement as an example of a drug will be described. As shown in FIG. 4A, the cover member 16 in a state where the cylindrical body 12 is inserted is placed in an upright state on a horizontal surface (a work table or the like). Then, since the cylindrical body 12 is supported by the cover member 16, the cylindrical body 12 stops with the proximal end opening 12 b facing upward. That is, the cover member 16 functions as a stand that holds the cylindrical body 12 in an upright state.

Next, as shown in FIG. 4B, a predetermined amount of bone cement 66 adjusted in advance and placed in the container 65 is poured into the cylindrical body 12 from above the cylindrical body 12 through the proximal end opening 12b. At this time, since the cylindrical body 12 is supported by the cover member 16 and maintained in an upright state, the operator does not need to hold the cylindrical body 12 while pouring the bone cement 66 into the cylindrical body 12. For this reason, the injection | pouring of the bone cement 66 in the cylindrical body 12 can be performed simply.

After a predetermined amount of bone cement 66 has been injected into the cylindrical body 12, next, as shown in FIG. 4C, the pusher 14 with the guide member 42 attached is inserted into the cylindrical body 12 from the proximal end opening 12b. And the guide member 42 and the cover member 16 are screwed together and fixed to each other. In this case, in the cylindrical body 12, some air exists above the bone cement 66 (between the bone cement 66 and the pusher 14). In a state where air is mixed in the cylindrical body 12, it becomes difficult to discharge the bone cement 66 due to the air acting as a damper, or even if the bone cement 66 can be discharged, the responsiveness is poor, and the bone of the bone cement 66 It becomes difficult to accurately control the amount injected into the inside. For this reason, the air discharge operation | work which extracts the air in the cylindrical body 12 is performed.

In the air discharging operation, as shown in FIG. 4D, the tip of the medicine injection device 10 is turned upward, and the apparatus waits for a while. Then, the air gradually rises in the bone cement 66, and finally goes out above the bone cement. Then, by rotating the pusher 14 in the circumferential direction with respect to the cylindrical body 12 and moving it forward, the air can be completely discharged from the cylindrical body 12.

Next, an operation method of the drug injection device 10 filled with the bone cement 66 will be described taking as an example a case where a percutaneous vertebroplasty is performed using the drug injection device 10.

As shown in FIG. 5A, the tubular body 12 of the drug injection device 10 and the injection port 74 of the bone cement injection needle 72 pierced into the bone 70 to be injected with the bone cement 66 are connected via the extension tube 80. Link. By using the extension tube 80, the medicine injection tool 10 can be operated in a state where the hand of the operator (user) is retracted outside the X-ray irradiation region.

Here, the bone cement injection needle 72 includes a hollow puncture needle 76 made of, for example, a metal material, and a handle 78 made of, for example, a resin material fixed to the proximal end portion of the puncture needle 76. Have. An injection port 74 communicating with the lumen (hollow part) of the puncture needle 76 is provided at the upper part of the handle 78. One end of the extension tube 80 is provided with a connector 82 that is detachably connected to the injection port 74, and the other end of the extension tube 80 is a connector that is detachable from the distal end tube portion 20 and the lock portion 28 of the cylindrical body 12. 84 is provided.

The extension tube 80 preferably has a configuration in which a thread such as Kevlar (registered trademark), nylon, polyphenylene sulfide, stainless steel or the like is wound around the flexible tube wall or on the outer surface in a net or coil shape from the viewpoint of pressure resistance. However, it may be a multi-layer tube in which chemical resistant polypropylene or fluororesin is disposed only on the inner surface. The length of the extension tube 80 is preferably set to about 200 to 500 mm so that the operator's (user's) hand can be surely retracted outside the X-ray irradiation region. Further, the distal end portion of the extension tube 80 may be angled.

In FIG. 5A, the connector 82 provided at one end of the extension tube 80 is connected to the injection port 74 of the handle 78, and the connector 84 provided at the other end of the extension tube 80 is connected to the distal end tube portion of the cylindrical body 12. 20 and the lock portion 28.

In such a state, the bone cement 66 filled in the drug injection device 10 is discharged and injected into the bone 70 under X-ray fluoroscopy. In this injection operation, as shown in FIG. 5B, the pusher 14 is moved to the distal end side with respect to the cylindrical body 12 by rotating the pusher 14. Then, as the pusher 14 moves toward the distal end side with respect to the cylindrical body 12, the filling chamber 26 is pressurized to a high pressure, and the bone cement 66 moves the distal end pipe portion 20, the extension tube 80 and the bone cement injection needle 72. And injected into the bone 70. The bone cement 66 is injected up to the target injection amount by such a rotation operation on the pusher 14.

During the injection operation, the operator of the drug injection tool 10 holds the cylindrical body 12 with fingers, and the periphery of the cylindrical body 12 is covered with the cover member 16, and the cylindrical body 12, the cover member 16, Since the gap 48 formed between the two functions as a heat insulating layer, it is possible to suppress body temperature from being transmitted to the bone cement 66 in the tubular body 12 through the fingers of the operator during operation. Therefore, the bone cement 66 is suppressed from being heated by the body temperature of the operator, and the increase rate of the viscosity of the bone cement 66 in the cylindrical body 12 can be suppressed.

In the above-described method of using the pharmaceutical injection tool 10, the extension tube 80 is used to avoid exposure to X-rays when injecting the bone cement 66 under fluoroscopy. For example, the bone cement 66 under CT fluoroscopy is used. May be omitted, and the distal end tube portion 20 of the cylindrical body 12 of the drug injector 10 and the injection port 74 of the bone cement injection needle 72 may be directly connected.

As described above, according to the pharmaceutical injection device 10 according to the present embodiment, since the periphery of the cylindrical body 12 is covered with the cover member 16, the body temperature is increased in the cylindrical body 12 through the fingers of the operator during operation. Transmission to the other drug (bone cement 66) is suppressed. For this reason, the influence by heat being transmitted to a chemical | medical agent can be reduced.

Further, since the cover member 16 also functions as a stand for standing the cylindrical body 12, the operator can pour the drug from the proximal end opening 12b of the cylindrical body 12 without gripping the cylindrical body 12. Therefore, the filling operation of the medicine can be performed easily.

In the case of the present embodiment, a gap 48 is formed between the cover member 16 and the cylindrical body 12 along the circumferential direction of the cylindrical body 12. Therefore, when the gap 48 functions as a heat insulating layer, heat transfer from the user to the medicine in the cylindrical body 12 can be more effectively reduced.

In the case of the present embodiment, the cover member 16 can be displaced in the axial direction with respect to the tubular body 12, and the cover member 16 is displaced in the most proximal direction with respect to the tubular body 12. The tip of the body 12 protrudes from the tip of the cover member 16. According to this configuration, since the tip of the cylindrical body 12 can be protruded from the cover member 16 after filling the cylindrical body 12 with the medicine, another member such as a bone cement injection needle 72 is provided on the cylindrical body 12. Or it is easy to connect the extension tube 80.

The drug injection device 10 according to the present embodiment includes a guide member 42 that can be attached to and detached from the cylindrical body 12, and the pusher 14 is inserted in a screwed state, and the guide member 42 further includes the cylindrical body 12. The cylindrical body 12 and the cover member 16 are fixed so that they cannot be displaced relative to each other in the axial direction. According to this configuration, by fixing and integrating the cover member 16 with respect to the cylindrical body 12, the drug injection tool 10 can be stably held when using the drug injection tool 10, and the operability is excellent. In addition, the guide member 42 has not only a function of guiding the movement of the pusher 14 with respect to the cylindrical body 12 but also a function of mutually fixing the cylindrical body 12 and the cover member 16. It is not necessary to configure the medicine injection device 10 as individual parts, and the drug injection device 10 can be configured simply.

In the case of the present embodiment, since the flange portion 22 provided at the proximal end of the cylindrical body 12 is sandwiched between the cover member 16 and the guide member 42 in the axial direction, the cylindrical body 12 and the cover member 16 are axially disposed. It can be firmly fixed in a state in which relative movement is prevented.

Since the medicine injection device 10 according to the present embodiment includes the rotation preventing means 60 (60a) that prevents relative rotation of the cylindrical body 12 and the cover member 16 in the circumferential direction, the cover member 16 is gripped (the cover member 16). Even when the pusher 14 is rotated in a state where the rotation of the cylindrical body 12 is prevented, the cylindrical body 12 can be prevented from being rotated. For this reason, the extension tube 80 or the bone cement injection needle 72 connected to the tubular body 12 can be prevented from rotating with the rotation of the pusher 14, and the procedure is not hindered.

In the above description, the present invention has been described with reference to preferred embodiments. However, the present invention is not limited to the above-described embodiments, and various modifications can be made without departing from the scope of the present invention. Needless to say.

For example, in the above-described embodiment, the “screw-in type” in which the pusher 14 is moved forward by rotating the pusher 14 with respect to the tubular body 12 is employed. However, the present invention is not limited to this, and the tubular body. The pusher 14 is slidable in the axial direction with respect to 12, and the pusher 14 is moved forward by pressing the pusher 14 against the cylindrical body 12 without rotating the pusher 14. A “push-in type” may be employed.

In the above-described embodiment, the coupling structure between the guide member 42 and the cover member 16 is screw fitting. However, the coupling structure is not limited to this, and other coupling structures, for example, project outward to the base end of the cover member 16. An engagement piece is provided, and a groove portion that can be fitted to the engagement piece is provided in the guide member 42. By the relative rotation of the cover member 16 and the guide member 42, the engagement piece and the groove portion are engaged and disengaged. It is also possible to adopt a structure capable of

In the above-described embodiment, a configuration in which the guide member 42 is fixed to the cylindrical body 12 by coupling the cover member 16 and the guide member 42 is adopted. A configuration that is fixed to the cylindrical body 12 may be employed. In this case, for example, a male screw portion is provided on the outer peripheral portion of the base end of the cylindrical body 12, and the second female screw portion 54b provided on the guide member 42 and the male screw portion are screwed together to form a cylindrical shape. A guide member 42 is fixed to the body 12.

Claims

A drug injection device (10) for discharging a drug filled inside,
A cylindrical body (12) having a medicine discharge port (12a) provided at the distal end and an opening (12b) provided at the proximal end and filled with the medicine;
A pusher (14) that is liquid-tightly inserted into the hollow portion of the cylindrical body (12) and is movable in the axial direction within the cylindrical body (12);
In order to prevent body temperature from being transmitted to the medicine in the tubular body (12) via the operator's fingers when operating the medicine infusion device (10), the periphery of the tubular body (12) is A cover member (16) for covering,
The cover member (16) is configured to be able to support the cylindrical body (12) with the opening (12b) facing upward.
A drug injection device (10) characterized by the above.
The drug injection device (10) according to claim 1, wherein
A gap (48) is formed between the cover member (16) and the cylindrical body (12) along the circumferential direction of the cylindrical body (12).
A drug injection device (10) characterized by the above.
The drug injection device (10) according to claim 1, wherein
The cover member (16) includes a fitting portion (44) fitted to the outer peripheral portion of the cylindrical body (12), and an enlarged diameter portion (45) having an inner diameter larger than the inner diameter of the fitting portion (44). )
In a state where the cylindrical body (12) is inserted through the cover member (16), an inner peripheral surface of the enlarged diameter portion (45) of the cover member (16) and an outer peripheral surface of the cylindrical body (12). An annular gap (48) extending in the axial direction is formed between
A drug injection device (10) characterized by the above.
The drug injection device (10) according to claim 1, wherein
The cover member (16) is displaceable in the axial direction with respect to the cylindrical body (12),
In a state where the cover member (16) is displaced to the most proximal side with respect to the tubular body (12), the distal end of the tubular body (12) protrudes from the distal end of the cover member (16).
A drug injection device (10) characterized by the above.
The drug injection device (10) according to claim 1, wherein
A guide member (42) that can be attached to and detached from the cover member (16) and into which the pusher (14) is inserted in a screwed state;
In a state where the guide member (42) is connected to the cover member (16), the cylindrical body (12) and the cover member (16) are fixed so as not to be relatively displaceable in the axial direction.
A drug injection device (10) characterized by the above.
The drug injection device (10) according to claim 5,
A flange portion (22) is provided at the proximal end of the cylindrical body (12),
The flange portion (22) is sandwiched in the axial direction by the cover member (16) and the guide member (42).
A drug injection device (10) characterized by the above.
The drug injection device (10) according to claim 5,
Rotation prevention means (60, 60a) for preventing circumferential rotation of the cylindrical body (12) and the cover member (16);
A drug injection device (10) characterized by the above.