WO2013127373A3 - Anticuerpos recombinantes con especificidad dual por gangliósidos y su uso - Google Patents

Anticuerpos recombinantes con especificidad dual por gangliósidos y su uso Download PDF

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Publication number
WO2013127373A3
WO2013127373A3 PCT/CU2013/000001 CU2013000001W WO2013127373A3 WO 2013127373 A3 WO2013127373 A3 WO 2013127373A3 CU 2013000001 W CU2013000001 W CU 2013000001W WO 2013127373 A3 WO2013127373 A3 WO 2013127373A3
Authority
WO
WIPO (PCT)
Prior art keywords
gangliosides
antibodies
dual specificity
recombinant antibodies
relates
Prior art date
Application number
PCT/CU2013/000001
Other languages
English (en)
French (fr)
Other versions
WO2013127373A2 (es
Inventor
Ernesto Moreno Frias
Gertrudis Rojas Dorantes
Ana Victoria CASADESUS PAZOS
Original Assignee
Centro De Inmunologia Molecular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
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Priority to US14/379,628 priority Critical patent/US9527920B2/en
Priority to JP2014559092A priority patent/JP5933044B2/ja
Priority to EP13713074.6A priority patent/EP2821417A2/en
Priority to KR1020147024181A priority patent/KR20140126349A/ko
Priority to MX2014010456A priority patent/MX2014010456A/es
Priority to CN201380011913.7A priority patent/CN104136463B/zh
Priority to AU2013225453A priority patent/AU2013225453A1/en
Application filed by Centro De Inmunologia Molecular filed Critical Centro De Inmunologia Molecular
Priority to SG11201405151YA priority patent/SG11201405151YA/en
Priority to EA201491618A priority patent/EA201491618A1/ru
Priority to CA2865050A priority patent/CA2865050A1/en
Publication of WO2013127373A2 publication Critical patent/WO2013127373A2/es
Publication of WO2013127373A3 publication Critical patent/WO2013127373A3/es
Priority to TNP2014000330A priority patent/TN2014000330A1/fr
Priority to PH12014501950A priority patent/PH12014501950A1/en
Priority to IL234394A priority patent/IL234394A0/en
Priority to ZA2014/07043A priority patent/ZA201407043B/en
Priority to HK14112117.7A priority patent/HK1198654A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La presente invención se relaciona con nuevos anticuerpos monoclonales y fragmentos de estos anticuerpos, con especificidad dual y alta afinidad por los gangliósidos N-acetil GM3 y N-glicolil GM3, y que no reconocen otros gangliósidos. En otro aspecto, la presente invención se relaciona con el uso de estos anticuerpos y sus fragmentos en la terapia de tumores que tienen una expresión significativa de cualquiera de los dos antígenos reconocidos por estos anticuerpos, o una expresión mixta de ambos antígenos. Así como al uso de estos anticuerpos en el diagnóstico de tumores que expresen al menos uno de los antígenos.
PCT/CU2013/000001 2012-03-01 2013-02-21 Anticuerpos recombinantes con especificidad dual por gangliósidos y su uso WO2013127373A2 (es)

Priority Applications (15)

Application Number Priority Date Filing Date Title
SG11201405151YA SG11201405151YA (en) 2012-03-01 2013-02-21 Recombinant antibodies having dual specificity for gangliosides and use thereof
EA201491618A EA201491618A1 (ru) 2012-03-01 2013-02-21 Рекомбинантные антитела с двойной специфичностью к ганглиозидам и их применение
JP2014559092A JP5933044B2 (ja) 2012-03-01 2013-02-21 ガングリオシドに対する二重特異性を有する組換え抗体及びこれらの使用
CA2865050A CA2865050A1 (en) 2012-03-01 2013-02-21 Recombinant antibodies having dual specificity for gangliosides and use thereof
MX2014010456A MX2014010456A (es) 2012-03-01 2013-02-21 Anticuerpos recombinantes con especificidad dual por gangliosidos y su uso.
CN201380011913.7A CN104136463B (zh) 2012-03-01 2013-02-21 具有对于神经节苷脂的双重特异性的重组抗体以及其用途
AU2013225453A AU2013225453A1 (en) 2012-03-01 2013-02-21 Recombinant antibodies having dual specificity for gangliosides and use thereof
US14/379,628 US9527920B2 (en) 2012-03-01 2013-02-21 Recombinant antibodies having dual specificity for gangliosides and use thereof
KR1020147024181A KR20140126349A (ko) 2012-03-01 2013-02-21 강글리오시드에 대한 이중 특이성을 갖는 재조합 항체 및 그 용도
EP13713074.6A EP2821417A2 (en) 2012-03-01 2013-02-21 Recombinant antibodies having dual specificity for gangliosides and use thereof
TNP2014000330A TN2014000330A1 (en) 2012-03-01 2014-07-31 Recombinant antibodies having dual specificity for gangliosides and use thereof
PH12014501950A PH12014501950A1 (en) 2012-03-01 2014-08-29 Recombinant antibodies having dual specificity for gangliosides and use thereof
IL234394A IL234394A0 (en) 2012-03-01 2014-08-31 Recombinant antibodies with dual specificity for gangliosides and their use
ZA2014/07043A ZA201407043B (en) 2012-03-01 2014-09-29 Recombinant antibodies having dual specificity for gangliosides and use thereof
HK14112117.7A HK1198654A1 (en) 2012-03-01 2014-12-02 Recombinant antibodies having dual specificity for gangliosides and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CUCU/P/2012-0035 2012-03-01
CU20120035A CU24120B1 (es) 2012-03-01 2012-03-01 Anticuerpos recombinantes con especificidad dual por los gangliósidos n-acetil gm3 y n-glicolil gm3

Publications (2)

Publication Number Publication Date
WO2013127373A2 WO2013127373A2 (es) 2013-09-06
WO2013127373A3 true WO2013127373A3 (es) 2013-10-31

Family

ID=48039960

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CU2013/000001 WO2013127373A2 (es) 2012-03-01 2013-02-21 Anticuerpos recombinantes con especificidad dual por gangliósidos y su uso

Country Status (22)

Country Link
US (1) US9527920B2 (es)
EP (1) EP2821417A2 (es)
JP (1) JP5933044B2 (es)
KR (1) KR20140126349A (es)
CN (1) CN104136463B (es)
AR (1) AR090207A1 (es)
AU (1) AU2013225453A1 (es)
CA (1) CA2865050A1 (es)
CL (1) CL2014002236A1 (es)
CO (1) CO7051011A2 (es)
CU (1) CU24120B1 (es)
EA (1) EA201491618A1 (es)
HK (1) HK1198654A1 (es)
IL (1) IL234394A0 (es)
MX (1) MX2014010456A (es)
PE (1) PE20142277A1 (es)
PH (1) PH12014501950A1 (es)
SG (1) SG11201405151YA (es)
TN (1) TN2014000330A1 (es)
TW (1) TW201348259A (es)
WO (1) WO2013127373A2 (es)
ZA (1) ZA201407043B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU24120B1 (es) * 2012-03-01 2015-08-27 Ct De Inmunología Molecular Anticuerpos recombinantes con especificidad dual por los gangliósidos n-acetil gm3 y n-glicolil gm3
CN104651314B (zh) * 2015-02-14 2018-06-19 百泰生物药业有限公司 获得高产稳定表达细胞克隆的方法及由此获得的抗体分子
EP3277713A1 (en) * 2015-03-31 2018-02-07 VHsquared Limited Polypeptides

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1623997A1 (en) * 2003-04-23 2006-02-08 Centro de Inmunologia Molecular Recombinant antibodies and fragments recognising ganglioside n-glycolyl-gm3 and use thereof in the diagnosis and treatment of tumours

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4107154A1 (de) 1990-10-11 1992-04-16 Boehringer Mannheim Gmbh Monoklonale antikoerper gegen melanom
CU22731A1 (es) 1998-02-05 2002-02-28 Centro Inmunologia Molecular Anticuerpo monoclonal que reconoce el oligosacárido ácido siálico n´glicolilado-galactosa-glucosa (ngcneu-gal-glu) en tumores malignos y composiciones farmacéuticas que los contienen
CU24120B1 (es) * 2012-03-01 2015-08-27 Ct De Inmunología Molecular Anticuerpos recombinantes con especificidad dual por los gangliósidos n-acetil gm3 y n-glicolil gm3

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1623997A1 (en) * 2003-04-23 2006-02-08 Centro de Inmunologia Molecular Recombinant antibodies and fragments recognising ganglioside n-glycolyl-gm3 and use thereof in the diagnosis and treatment of tumours

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HOON D S ET AL: "MOLECULAR CLONING OF A HUMAN MONOCLONAL ANTIBODY REACTIVE TO GANGLIOSIDE GM3 ANTIGEN ON HUAMN CANCERS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 53, no. 21, 1 November 1993 (1993-11-01), pages 5244 - 5250, XP002017118, ISSN: 0008-5472 *
ROJAS G ET AL: "Light-chain shuffling results in successful phage display selection of functional prokaryotic-expressed antibody fragments to N-glycolyl GM3 ganglioside", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 293, no. 1-2, 1 October 2004 (2004-10-01), pages 71 - 83, XP004634276, ISSN: 0022-1759, DOI: 10.1016/J.JIM.2004.07.002 *
ROJAS GERTRUDIS ET AL: "Engineering the Binding Site of an Antibody against N-Glycolyl GM3: From Functional Mapping to Novel Anti-ganglioside Specificities", ACS CHEMICAL BIOLOGY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 8, no. 2, 1 February 2013 (2013-02-01), pages 376 - 386, XP009171240, ISSN: 1554-8929, DOI: 10.1021/CB30037541 *
U. KRENGEL: "Structure and Molecular Interactions of a Unique Antitumor Antibody Specific for N-Glycolyl GM3", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 7, 15 December 2003 (2003-12-15), pages 5597 - 5603, XP055071570, ISSN: 0021-9258, DOI: 10.1074/jbc.M311693200 *
WATARAI S ET AL: "PRODUCTION OF MONOCLONAL ANTIBODIES DIRECTED TO HANGANUTZIU-DEICHER ACTIVE GANGLIOSIDES, N-GLYCOLYLNEURAMINIC ACID-CONTAINING GANGLIOSIDES", JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOCIETY / OUP, TOKYO; JP, vol. 117, no. 5, 1 January 1995 (1995-01-01), pages 1062 - 1069, XP008049192, ISSN: 0021-924X *

Also Published As

Publication number Publication date
AU2013225453A1 (en) 2014-09-25
AR090207A1 (es) 2014-10-29
CU24120B1 (es) 2015-08-27
CN104136463A (zh) 2014-11-05
JP5933044B2 (ja) 2016-06-08
EP2821417A2 (en) 2015-01-07
CL2014002236A1 (es) 2014-12-05
ZA201407043B (en) 2015-12-23
WO2013127373A2 (es) 2013-09-06
US9527920B2 (en) 2016-12-27
CA2865050A1 (en) 2013-09-06
MX2014010456A (es) 2014-10-13
IL234394A0 (en) 2014-10-30
CU20120035A7 (es) 2013-10-29
PE20142277A1 (es) 2015-01-15
SG11201405151YA (en) 2014-10-30
US20150093385A1 (en) 2015-04-02
TW201348259A (zh) 2013-12-01
KR20140126349A (ko) 2014-10-30
JP2015516367A (ja) 2015-06-11
TN2014000330A1 (en) 2015-12-21
CO7051011A2 (es) 2014-09-10
PH12014501950A1 (en) 2014-11-24
EA201491618A1 (ru) 2014-12-30
CN104136463B (zh) 2016-08-24
EP2821417A9 (en) 2015-04-01
HK1198654A1 (en) 2015-05-22

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