WO2013125225A1 - Composition for preventing or treating allergic disease or major depressive disorder (depression) - Google Patents

Composition for preventing or treating allergic disease or major depressive disorder (depression) Download PDF

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Publication number
WO2013125225A1
WO2013125225A1 PCT/JP2013/000969 JP2013000969W WO2013125225A1 WO 2013125225 A1 WO2013125225 A1 WO 2013125225A1 JP 2013000969 W JP2013000969 W JP 2013000969W WO 2013125225 A1 WO2013125225 A1 WO 2013125225A1
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WO
WIPO (PCT)
Prior art keywords
formula
antidoti
orengedokuto
coptidis
composition
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Ceased
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PCT/JP2013/000969
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English (en)
French (fr)
Inventor
Yoshiteru SHIMOIDE
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Individual
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Individual
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Priority to US13/822,864 priority Critical patent/US20140234366A1/en
Priority to JP2014541247A priority patent/JP2015508052A/ja
Priority to EP13752274.4A priority patent/EP2731618A4/en
Publication of WO2013125225A1 publication Critical patent/WO2013125225A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Definitions

  • the present invention relates to a composition including a kampo combination drug, for preventing or treating atopic dermatitis, bronchial asthma, allergic rhinitis or major depressive disorder (depression).
  • the present inventors studied diligently for kampo medicines effective for patients with a specific disease, atopic dermatitis, bronchial asthma, allergic rhinitis or major depressive disorder, without being based on the sho of the patient. As a result, they found that a mixture of Formula antidoti coptidis (orengedokuto) and Formula repletionis animalis et supletionis medii (hochuekkito) or a mixture of Formula antidoti coptidis (orengedokuto) and Formula glycyrrhizae atractylodis cinnamomi hoelen (ryokeijutsukanto) cures these diseases in high efficiency by suppressing the activation of macrophage lineage cells in the living body.
  • Formula antidoti coptidis is a kampo medicine prepared by mixing crude drugs of Copridis Rhizoma (oren), Scutellaria Root (ogon), Phellodendron Bark (obaku) and Gardenia Fruit (sanshishi).
  • mixed weights of the dried crude drugs are for example, Copridis Rhizoma 1.5 g-2.0 g, Scutellaria Root 3.0 g, Phellodendron Bark 1.5 g-3.0 g, Gardenia Fruit 2.0 g-3.0 g.
  • Copridis Rhizoma refers to dried rhizome (without most of the root) of Coptis japonica Makino or other species in the same genus in the family of Ranunculaceae.
  • Scutellaria Root refers to dried root (without periderm) of Scutellaria baicalensis Georgi in the family of Labiatae.
  • Phellodendron Bark refers to dried bark (without periderm (cork-cortex)) of Phellodendron amurense RUPR. or other species in the same genus in the family of Rutaceae.
  • Other species in the same genus include, for example, Phellodendron chinense Schneider.
  • Gardenia Fruit refers to dried fruits of Gardenia jasminoides ellis or other species in the same genus in the family of Rubiaceae.
  • CD35 Activity of CD35 is involved in development of major depressive disorder.
  • a mixture of Formula antidoti coptidis (orengedokuto) and Formula glycyrrhizae atractylodis cinnamomi hoelen (ryokeijutsukanto) according to the invention are capable of suppressing activities of macrophage linage cells, and capable of preventing or treating major depressive disorder by suppressing activities of soluble CD35.
  • a composition according to the invention can be used as a food and beverage composition or a feed composition, such as powder, granule, liquid, or paste.
  • Food and beverage include health food and beverage, designated health food and beverage, functional nutritional food and beverage, supplement food and beverage, and the like.
  • designated health food refers to food taken in diet for a specific health benefit and indicating that the benefit is expected thorough eating it.
  • the commercial Formula antidoti coptidis (orengedokuto) extract and the commercial Formula glycyrrhizae atractylodis cinnamomi hoelen (ryokeijutsukanto) extract can be divided into aliquots of half the indicated daily amount and mixed to be administered twice a day before morning and evening meals.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)
PCT/JP2013/000969 2012-02-23 2013-02-21 Composition for preventing or treating allergic disease or major depressive disorder (depression) Ceased WO2013125225A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US13/822,864 US20140234366A1 (en) 2012-02-23 2013-02-21 Composition for preventing or treating allergic disease or major depressive disorder (depression)
JP2014541247A JP2015508052A (ja) 2012-02-23 2013-02-21 アレルギー性疾患又は大鬱病性障害（うつ病）の予防又は治療用組成物
EP13752274.4A EP2731618A4 (en) 2012-02-23 2013-02-21 COMPOSITION FOR THE PREVENTION OR TREATMENT OF ALLERGIC DISEASES OR SERIOUSLY DEPRESSIVE SUFFERINGS (DEPRESSION)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012001231 2012-02-23
JPPCT/JP2012/001231 2012-02-23

Publications (1)

Publication Number Publication Date
WO2013125225A1 true WO2013125225A1 (en) 2013-08-29

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Application Number Title Priority Date Filing Date
PCT/JP2013/000969 Ceased WO2013125225A1 (en) 2012-02-23 2013-02-21 Composition for preventing or treating allergic disease or major depressive disorder (depression)

Country Status (4)

Country Link
US (1) US20140234366A1 (enExample)
EP (1) EP2731618A4 (enExample)
JP (1) JP2015508052A (enExample)
WO (1) WO2013125225A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP6154566B1 (ja) * 2017-04-17 2017-06-28 義輝 霜出 慢性甲状腺炎による甲状腺機能低下症のホルモン異常を正常化させる漢方薬

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US10877021B2 (en) * 2016-04-21 2020-12-29 Osaka University Device for biological material detection, detection apparatus for biological material detection, method for measuring ion current, and method for identifying biological material
CN107510832A (zh) * 2017-08-31 2017-12-26 贵阳中医学院第二附属医院 一种治疗维持性血透患者抑郁障碍的药物及其制备方法
JP6401414B1 (ja) * 2018-03-30 2018-10-10 義輝 霜出 アルツハイマー型認知症または軽度認知障害の認知機能を改善するとともに、それらに合併する過活動膀胱、および便秘症からなる群の少なくとも１つの疾患を一剤で治療する漢方薬
JP6691182B2 (ja) * 2018-09-06 2020-04-28 義輝 霜出 アルツハイマー型認知症または軽度認知障害の認知機能を改善するとともに、それらに合併する過活動膀胱、便秘症および慢性腎臓病からなる群の少なくとも１つの疾患を一剤で治療する漢方薬
CN114699493A (zh) * 2022-04-06 2022-07-05 吴亚坤 治疗荨麻疹、湿疹、过敏/变态反应体质的中药组方

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KYOSUKE MURATA: "2010nen6gatsu20nichi [Inka] to Atopi Sei Hifuen", KAMPOYAKU SENMON MURATA KAMPO DO YAKKYOKU (YAMAGUCHI KEN SHIMONOSEKI SHI) NO KINKYO HOUKOKU, 20 June 2010 (2010-06-20), XP008172458, Retrieved from the Internet <URL:http://murata-kanpo.seesaa.net/archives/201006-1.html> *
MASAMITSU ISHII ET AL.: "Atopi Sei Hifuen no Kampo Chiryo(l) Atopi Sei Hifuen to Hozai(Ge)", PROGRESS KAMPO MEDICINE, 2002, pages 128 - 137, XP008172771 *
NAOKI INAGAKI: "Evaluation of Kampo medicines using mouse allergic dermatitis models", SKIN RESEARCH 0018-1390, vol. 9, no. SUPPL., 2010, pages 34 - 41, XP008172437 *
See also references of EP2731618A4 *
SHIGENOBU KAMINIWA ET AL.: "Seishin Ka Ryoikino Kampo Chiryo", JOURNAL OF JAPANESE ASSOCIATION OF ORIENTAL PSYCHOSOMATIC MEDICINE, vol. 18, no. 1/2, 2003, pages 5 - 10, XP008172619 *
TAKUZO NAGANO ET AL.: "Atopi Sei Hifuen niokeru QOL Chiryo Koka oyobi Utsu Jotai tono Kankei(Dai 2 Ho)", ALLERGY, vol. 51, no. 9/10, 2002, pages 946, XP008172440 *
TERUO SAITO: "Treatment of nose disease. Pollinosis in the spring and other", TOSEI KAMPO KENKYU SHITSU, vol. 22, no. 3, 1999, pages 8 - 11, XP008172622 *
YOUKO KATAOKA ET AL.: "Utsu Byo wo Gappei shita Atopi Sei Hifuen no Ziken Rei 28 Rei no Kento", ALLERGY, vol. 53, no. 2/3, 2004, pages 363, XP008172439 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6154566B1 (ja) * 2017-04-17 2017-06-28 義輝 霜出 慢性甲状腺炎による甲状腺機能低下症のホルモン異常を正常化させる漢方薬

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Publication number Publication date
US20140234366A1 (en) 2014-08-21
EP2731618A1 (en) 2014-05-21
JP2015508052A (ja) 2015-03-16
EP2731618A4 (en) 2016-02-10

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