WO2013108963A1

WO2013108963A1 - Dental block bone graft and method for manufacturing same

Info

Publication number: WO2013108963A1
Application number: PCT/KR2012/003450
Authority: WO
Inventors: 조성용
Original assignee: Cho Seong-Yong
Priority date: 2012-01-17
Filing date: 2012-05-03
Publication date: 2013-07-25
Also published as: KR101175051B1

Abstract

The present invention relates to a dental block bone graft which can be used in alveolar bone loss treatment. More particularly, the present invention relates to a dental block bone graft comprised of cortical bone and cancellous bone, which are similar to human alveolar bone, and to a method for manufacturing same. For the dental block bone graft of the present invention, one selected from dental enamel from the patient's own tissue, heterogeneous dental enamel, or homogenous dental enamel is formed into cortical and cancellous bone, which are similar to human alveolar bone, and after the graft is administered to the patient, the volume of the graft does not diminish while newly generated bone is formed. In contrast to the prior art, in which a greater amount of a graft is inserted due to the inevitable loss of block-type grafts, which causes pain and gum disfigurement for the patient, the present invention maintains the same shape without any loss even during the forming of newly generated bone. Therefore, it is sufficient to insert a graft only in the amount of alveolar bone which was lost so as to reduce pain for the patient and maintain aesthetics by preventing a fixture from being outwardly exposed. Also, the graft is formed of cortical bone and cancellous bone, which are similar in form to human alveolar bone, wherein that the cancellous bone portion accelerates fusion with the alveolar bone, thereby reducing the time taken to form newly generated solid bone which can support a fixture in implant treatment, and the cortical bone portion has the effect of preventing a loss in volume of the graft during the formation of newly generated bone.

Description

Tooth block bone graft and its manufacturing method

The present invention relates to a tooth block bone graft for repairing alveolar bone defects. More particularly, the present invention relates to a dental bone block graft material and a method of manufacturing the same, wherein the dental block bone graft material comprises cortical bones and sponges similar to human alveolar bone.

Bone grafting substitutes (BGS) are the replacement of bone defects due to various dental diseases or trauma, disease degeneration, or other tissue loss, thereby filling the space within the bone tissue and forming new bone. Implants used to promote the disease.

The best alveolar bone graft substitute is a fresh autograft, which takes a portion of the patient's own bone and transplants it to another damaged area. Dental bone grafts provide bone substrates and living cells involved in bone formation at the site of transplantation, resulting in better bone formation, less immune rejection, and less bone absorption, resulting in bone conduction and bone induction. Very good, there is an advantage in the formation of a solid new bone that can support the fixture (fixture) in implant treatment.

Implants used in the treatment of alveolar bone defects are divided into powdered powders and block shaped blocks. Powder-type implants are used when the alveolar bone defects are small, and known techniques include Korean Patent Publication KR 10-2010-0040427, KR 10-2011-0092477 and KR 10-2010-0134306. Block form is a method of applying when filling the space while maintaining a constant form of a large number of alveolar bone defects, the known techniques are typical of Korea Patent Registration KR 10-1062381, KR 10-0978562 and the like.

Human alveolar bone is composed of cortical bone and cancellous bone, and while complementary to each other, known block membrane grafts are manufactured only in the form of spongy bone or sponge during the deliming process.

Therefore, the known block-type implants have a problem that when the new bone is formed, the skin surrounding the implant and the alveolar bone are partially absorbed by the biosynthesis and lose about 50% of the volume after the initial transplantation. have.

Therefore, in the tooth block bone graft material, it consists of cortical and spongy bones similar to the human alveolar bone, and the spongy bone area promotes union with the alveolar bone, thereby forming a solid new bone that can support a fixture in implant treatment, and cortical bone. The site requires a dental block bone graft that can maintain its shape after time-lapse.

The present invention has been invented to solve the above problems, the known block membrane graft is mostly made only in the form of spongy bone or sponge, in order to improve the problem that the graft is lost during the new bone formation process, the tooth made of cortical bone and spongy bone similar to the human alveolar bone It relates to a block bone graft material and a method of manufacturing the same.

Therefore, in the dental block bone graft material of the present invention, the cortical bone and the cancellous bone similar to the human alveolar bone, the spongy bone area promotes the union of the alveolar bone, thereby forming a solid new bone that can support the fixture in the implant treatment. Cortical bone area is characterized by maintaining the initial shape without the loss of the volume of the implant during the formation of new bone after the procedure.

The tooth block bone graft material of the present invention is formed of cortical bone and sponge bone similar to human alveolar bone through a series of processes using enamel of teeth collected from autologous, xenogeneic and allogeneic type, and new bone is implanted after the procedure in the patient. It is characterized in that no volume loss of the implant occurs during formation.

In addition, the tooth block bone graft material manufacturing method of the present invention, in the tooth block bone graft material, the first disinfecting step of removing the tooth, the teeth collected from the heterogeneous and homologous, the germs of the tooth, and remove tartar and soft tissues (a ); After step (a), the dentin of the tooth is completely removed, and a design step of designing an appropriate implant size using only enamel (b); After step (b), coating a portion of the tooth to form a cortical bone Step (c); After the step (c), the step of forming a spongy bone by drilling a plurality of holes (10) by a punching operation using a cloth mill in the other side coated; After the step (d), the first deliming step (e); After the step (e), removing the coating material attached to the step (c) (f); After the step (f), forming a screw hole (20) for fixing during alveolar bone graft (g); After step (g), secondary deliming step (h); After the step (h), the first washing step using sterile distilled water (i); After step (i), a degreasing step (J); After the step (J), the second washing and dehydration step using sterile distilled water and ethyl alcohol (k); After the step (k), the third washing step using sterile distilled water ((L); after the (L) step, the second disinfection using hydrogen peroxide (m); after the step (m), after the fourth step using sterile distilled water (N) washing step (n), after the step (n), lyophilization and sterilization step (o), further comprising the step of further washing in the step (n) the final product is cortical bone similar to the human alveolar bone It is characterized by consisting of spongy bone.

Finally, the tooth block bone graft manufacturing method of the present invention is characterized in that in the deliming step of the steps (e) and (h), using a solution of hydrochloric acid and citric acid.

While the prior art provides for pain and imbalanced gums to the patient by inserting more implants in consideration of the loss of implant volume, the present invention maintains its shape without loss in the process of new bone formation. As a result, implants need to be inserted as much as the alveolar bone defect, reducing pain and providing aesthetics. In the case of an implant procedure, the implant fixture can be prevented from being exposed to the outside to maintain aesthetics.

In addition, it consists of cortical and spongy bones similar to human alveolar bone, promoting alveolar bone and union, and induces the formation of new bone due to the tissue of the spongy bone to provide a solid support to the implant fixture.

In addition, since the use of autologous teeth in general, such as the effect of autologous bone graft can increase the amount of bone graft material, it is possible to improve the stability of the implant procedure.

In addition, the use of their own teeth to prevent the transmission of infectious diseases of xenograft (animal) implants, autologous teeth can be a safe, economical procedure without immune rejection.

Figure 1 is a preferred embodiment of the present invention method for producing tooth block bone graft

Figure 2 is a tooth block bone graft after the first disinfection step (a)

Figure 3 is a tooth block bone graft immediately after the design step (b) to remove the dentin, molded into a suitable shape with enamel

Figure 4 is a tooth block bone graft immediately after applying the coating to a portion in the coating step (c)

Figure 5 is a tooth block bone graft immediately after the drilling step (d) for the formation of spongy bone

Figure 6 is a tooth block bone graft comprising a screw hole for fixation at alveolar bone graft after removing the coating material

7 is a cross-sectional view of the dental block bone graft material of the final product in the form of cortical bone and spongy bone after a series of deliming, degreasing cleaning and disinfection

The scope of the present invention is not limited to this embodiment, and can be easily changed at the level of those skilled in the art, and any invention that is the same as the technical idea of the present invention falls within the scope of the present invention.

The present invention is based on the rules as defined by the Law on Bioethics and Safety, and the allogeneic teeth of the present invention are limited to being donated among the teeth discarded and discarded during dental treatment.

Figure 1 is a preferred embodiment of the present invention method for producing tooth block bone graft, Figure 2 is a tooth block bone graft material after the first disinfection step (a), Figure 3 removes the dentin, molded into a suitable shape with enamel One is a tooth block bone graft immediately after the design step (b), Figure 4 is a tooth block bone graft immediately after applying the coating to a portion in the coating step (c), Figure 5 is immediately after the drilling step (d) for the formation of spongy bone 6 is a tooth block bone graft material, Figure 6 is a tooth block bone graft material including a screw hole for fixation when implantation of the alveolar bone after removing the coating material, Figure 7 is a cortical bone and sponge bone form through a series of deliming, degreasing, cleaning and disinfection A cross-sectional view of the tooth block bone graft product of the final product.

In FIG. 1, i and j, and i and l are confused in the serial numbers, so that they are specified by J and L, respectively.

The present invention relates to a dental block bone graft material for alveolar bone defects required for implantation. More particularly, the present invention relates to a tooth block bone graft material and a method of manufacturing the same, wherein the tooth block bone graft material comprises cortical bones and spongy bones similar to human alveolar bone.

In the tooth block bone graft material of the present invention, by using the enamel of one tooth selected from autologous, heterogeneous, and allogeneic, the enamel is formed into cortical bones and sponges similar to human alveolar bone through a series of processes, and the implant is applied to the patient. It is characterized in that the volume loss of the implant does not occur during the formation of new bone after the procedure.

In addition, the tooth block bone graft manufacturing method, one tooth selected from the autologous, heterogeneous, allogeneic, and removing the germs of the tooth, the first disinfection step of removing tartar and soft tissue (a); After the step (a), the dentin of the tooth is completely removed, designing step of designing the implant size using only enamel (b); After step (b), coating a portion of the tooth to form a cortical bone (c); After the step (c), forming the spongy bone with a plurality of holes (10) by a punching operation using a cloth mill in the other side coated; After the step (d), the first deliming step (e); After the step (e), removing the coating material attached to the step (c) (f); After step (f), forming a screw hole for fixing during alveolar bone graft (g), after step (g), and second deliming step (h); After the step (h), the first washing step using sterile distilled water (i); After step (i), a degreasing step (J); After the step (J), the second washing and dehydration step using sterile distilled water and ethyl alcohol (k); After the step (k), the third washing step using sterile distilled water ((L); after the (L) step, the second disinfection using hydrogen peroxide (m); after the step (m), after the fourth step using sterile distilled water (N) washing step (n), after the step (n), lyophilization and sterilization step (o), further comprising the step of further washing in the step (n) the final product is cortical bone similar to the human alveolar bone It is characterized by consisting of spongy bone.

In addition, the method for producing a tooth block bone graft material, characterized in that in the deliming step of step (e) and (g), using a solution mixed with hydrochloric acid and citric acid.

The tooth block bone graft manufacturing method will be described in detail below.

The first disinfection step (a), which removes germs of teeth collected from the patient and removes tartar and soft tissues, soaks the teeth in 10 to 35% hydrogen peroxide drug for 1 to 10 hours or more, and then vibrates 10 to 300 RPM. First disinfection to remove germs from the outside of the tooth by stirring on the machine for 1 to 20 hours or more, and calculus, soft tissue, etc. attached to the tooth is primarily removed.

After step (a), design step (b) completely removes the dentin of the tooth and cuts to an appropriate graft size using only enamel. It also removes tartar, soft tissue, and nerves from your teeth.

After the step (b), the step of coating a portion of the tooth to form a cortical bone (c), the site to form a cortical bone to distinguish between the cortical bone (Canicalous bone) and the cortical bone similar to the bones of the human body Coated with a coating material. The coating material inhibits the drug action during the deliming operation, thereby preventing the enamel from becoming a sponge-like structure. The coating should be of a material that is adhesive, stable in chemical structure, and does not affect the processing drug.

After the step (c), the step (d) of forming the spongy bone with a plurality of holes 10 by a drilling operation using the fabric mill in the other side of the coating using a mill mill such as a laser, drill The dense holes 10 are formed in a predetermined pattern of squares of mm or less. Usually 30 to 80 holes 10 are formed per implant. The hole is formed to facilitate and effectively perform cleaning or degreasing, dehydration, and deliming. In addition, while going through the above process, the hole 10 is stretched so that it can be easily molded to fit the alveolar bone as well as the implantation operation when implanted into the alveolar bone.

After the step (d), the first deliming step (e) uses a mixed solution containing 1 to 20% citric acid and 1 to 50% hydrochloric acid as a main raw material. The mixed solution is suitably 20 to 40 times the volume of the designed implant. The deliming operation is immersed for 2 to 20 hours until the remaining amount of calcium in the spongy bone area, which is not coated in the mixed solution, becomes 1 to 50%, and is stirred on a vibration machine of 10 to 300 RPM at the same time.

After the step (e), step (f) of removing the coating material, the coating material attached to the step (c) by the physical operation to remove the coating site clean.

After the step (f), when the implant is implanted in the missing alveolar bone, forming a screw hole 20 for fixing the dental block bone graft (g).

After the step (g), the second deliming step (h) is performed in the same manner as the mixed solution of the first deliming step (e), when the calcium remaining amount of the site to form the cortical bone becomes 50 to 99% Until.

Through the above process, the cortical bone and the spongy bone has a tissue similar to the human alveolar bone.

After the step (h), the first washing step (i) using sterile distilled water is immersed in sterile distilled water 20 to 40 times the volume of the implant, put on a vibrating machine of 10 to 300 RPM and agitate for 10 minutes or more.

After the step (i), the degreasing step (J), after completely removing the sterile distilled water, immersed in 50 to 100% trichloromethane solution, put on a vibrating machine of 10 to 300RPM and stirred for 1 to 20 hours or more do.

After the step (J), the second washing and dehydration step (k) using sterile distilled water and ethyl alcohol, after washing in the same manner as in (h) to remove the trichloromethane solution of the degreasing step, After sterile distilled water is completely removed, soaked in 100% ethyl alcohol, put on a vibration machine of 10 to 300 RPM and stirred for 1 to 20 hours or more.

After the step (k), the third washing step using sterile distilled water ((L), is washed in the same manner as in (h).

After the step (L), the second disinfection using hydrogen peroxide (m) is immersed in 10 to 35% hydrogen peroxide for 1 to 10 hours or more, and then put on a vibration machine of 10 to 300 RPM to perform stirring for 1 to 10 hours or more. .

After step (m), the fourth washing step (n) using sterile distilled water is washed in the same manner as in (h). Further cleaning may be further included until the processed tooth remains completely removed from the washed tooth.

After the step (n), lyophilization and sterilization step (o), put the implant in the lyophilizer, lyophilized for 1 to 20 hours or more, and then sterilized in a radiation or EO gas sterilizer.

The above procedure is performed by implanting into the alveolar bone defect of the patient.

The tooth block bone graft of the present invention is composed of cortical bone and spongy bone, characterized in that the volume loss of the graft does not occur during the formation of new bone after the procedure in the patient. As a result, in the case of implantation, the implant fixture can be prevented from being exposed to the outside, thereby maintaining aesthetics. In addition, the tissue of the spongy bone induces the formation of new bone, providing a strong support for the implant fixture.

The present invention relates to a tooth block bone graft for repairing alveolar bone defects. More specifically, the dental block bone graft can be used in the field of dental bone block graft and its manufacturing method, characterized in that it consists of cortical bone and spongy bone similar to human alveolar bone.

Claims

Tooth block bone graft,

(A) a first disinfection step of removing one tooth from among autologous, xenogeneic, and allogeneic types, and removing germs of the tooth and removing tartar and soft tissue;

After the step (a), the dentin of the tooth is completely removed, designing step of designing the implant size using only enamel (b);

After step (b), coating a portion of the tooth to form a cortical bone (c);

After the step (c), the step of forming a spongy bone by drilling a plurality of holes (10) by a punching operation using a cloth mill in the other side coated;

After the step (d), the first deliming step (e);

After the step (e), removing the coating material attached to the step (c) (f);

After the step (f), forming a screw hole (20) for fixing during alveolar bone graft (g);

After step (g), a second deliming step (h);

After the step (h), the first washing step using sterile distilled water (i);

After step (i), a degreasing step (J);

After the step (J), the second washing and dehydration step using sterile distilled water and ethyl alcohol (k);

After the step (k), the third washing step using sterile distilled water ((L);

After the step (L), secondary disinfection using hydrogen peroxide (m);

After the step (m), the fourth washing step using sterile distilled water (n);

After the step (n), and lyophilization and sterilization step (o),

The method of manufacturing a tooth block bone graft material, characterized in that further comprising the step of (n) further comprising the end product is cortical bone and sponge bone similar to human alveolar bone.
The method of claim 1,

In the deliming step of step (e) and (h), a method for producing a dental block bone graft material, characterized in that using a mixture of hydrochloric acid and citric acid.
Tooth block bone graft,

Using the enamel of the collected tooth selected from autologous, xenogeneous, or allogeneic, the enamel is formed into cortical and sponge bones similar to human alveolar bone through a series of processes, and the new implant is formed while the new bone is formed after the procedure. A tooth block bone graft, characterized in that no volume loss occurs.