WO2013090648A1 - Modified nucleoside, nucleotide, and nucleic acid compositions - Google Patents
Modified nucleoside, nucleotide, and nucleic acid compositions Download PDFInfo
- Publication number
- WO2013090648A1 WO2013090648A1 PCT/US2012/069610 US2012069610W WO2013090648A1 WO 2013090648 A1 WO2013090648 A1 WO 2013090648A1 US 2012069610 W US2012069610 W US 2012069610W WO 2013090648 A1 WO2013090648 A1 WO 2013090648A1
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- Prior art keywords
- optionally substituted
- modified
- lipid
- nucleic acid
- formulation
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Abstract
Description
Claims
Priority Applications (62)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12858350.7A EP2791160B1 (en) | 2011-12-16 | 2012-12-14 | Modified mrna compositions |
CA2859387A CA2859387A1 (en) | 2011-12-16 | 2012-12-14 | Modified nucleoside, nucleotide, and nucleic acid compositions |
RS20220503A RS63244B1 (en) | 2011-12-16 | 2012-12-14 | Modified mrna compositions |
RU2014129004A RU2649364C2 (en) | 2011-12-16 | 2012-12-14 | Modified nucleoside, nucleotide and nucleic acid compositions |
DK12858350.7T DK2791160T3 (en) | 2011-12-16 | 2012-12-14 | MODIFIED MRNA COMPOSITIONS |
SG11201402666WA SG11201402666WA (en) | 2011-12-16 | 2012-12-14 | Modified nucleoside, nucleotide, and nucleic acid compositions |
MX2014007233A MX2014007233A (en) | 2011-12-16 | 2012-12-14 | Modified nucleoside, nucleotide, and nucleic acid compositions. |
KR1020147019601A KR20140102759A (en) | 2011-12-16 | 2012-12-14 | Modified nucleoside, nucleotide, and nucleic acid compositions |
LTEPPCT/US2012/069610T LT2791160T (en) | 2011-12-16 | 2012-12-14 | Modified mrna compositions |
EP22159380.9A EP4144378A1 (en) | 2011-12-16 | 2012-12-14 | Modified nucleoside, nucleotide, and nucleic acid compositions |
CN201280069609.3A CN104114572A (en) | 2011-12-16 | 2012-12-14 | Modified nucleoside, nucleotide, and nucleic acid compositions |
JP2014547454A JP2015501844A (en) | 2011-12-16 | 2012-12-14 | Modified nucleosides, nucleotides and nucleic acid compositions |
ES12858350T ES2923757T3 (en) | 2011-12-16 | 2012-12-14 | Modified mRNA compositions |
PL12858350T PL2791160T3 (en) | 2011-12-16 | 2012-12-14 | Modified mrna compositions |
SI201232001T SI2791160T1 (en) | 2011-12-16 | 2012-12-14 | Modified mrna compositions |
HRP20220717TT HRP20220717T1 (en) | 2011-12-16 | 2012-12-14 | Modified mrna compositions |
DE12858350.7T DE12858350T1 (en) | 2011-12-16 | 2012-12-14 | MODIFIED MRNA COMPOSITIONS |
AU2012352180A AU2012352180A1 (en) | 2011-12-16 | 2012-12-14 | Modified nucleoside, nucleotide, and nucleic acid compositions |
US14/103,188 US9220792B2 (en) | 2012-04-02 | 2013-12-11 | Modified polynucleotides encoding aquaporin-5 |
US14/104,585 US20140193482A1 (en) | 2012-04-02 | 2013-12-12 | Modified polynucleotides encoding v-myc avian myelocytomatosis viral oncogene homolog |
US14/104,531 US9107886B2 (en) | 2012-04-02 | 2013-12-12 | Modified polynucleotides encoding basic helix-loop-helix family member E41 |
US14/104,591 US9233141B2 (en) | 2012-04-02 | 2013-12-12 | Modified polynucleotides for the production of proteins associated with blood and lymphatic disorders |
US14/104,556 US9114113B2 (en) | 2012-04-02 | 2013-12-12 | Modified polynucleotides encoding citeD4 |
US14/104,568 US9095552B2 (en) | 2012-04-02 | 2013-12-12 | Modified polynucleotides encoding copper metabolism (MURR1) domain containing 1 |
US14/105,217 US20140255467A1 (en) | 2012-04-02 | 2013-12-13 | Modified polynucleotides encoding cytotoxic t-lymphocyte-associated protein 4 |
US14/105,214 US20140171485A1 (en) | 2012-04-02 | 2013-12-13 | Modified polynucleotides encoding cd28 molecule |
US14/105,224 US9220755B2 (en) | 2012-04-02 | 2013-12-13 | Modified polynucleotides for the production of proteins associated with blood and lymphatic disorders |
US14/105,210 US20150044277A1 (en) | 2012-04-02 | 2013-12-13 | Modified polynucleotides encoding caspase 3 |
US14/105,221 US20140255468A1 (en) | 2012-04-02 | 2013-12-13 | Modified polynucleotides encoding programmed cell death 1 |
US14/107,079 US9149506B2 (en) | 2012-04-02 | 2013-12-16 | Modified polynucleotides encoding septin-4 |
US14/106,957 US9050297B2 (en) | 2012-04-02 | 2013-12-16 | Modified polynucleotides encoding aryl hydrocarbon receptor nuclear translocator |
US14/106,988 US9301993B2 (en) | 2012-04-02 | 2013-12-16 | Modified polynucleotides encoding apoptosis inducing factor 1 |
US14/107,105 US9255129B2 (en) | 2012-04-02 | 2013-12-16 | Modified polynucleotides encoding SIAH E3 ubiquitin protein ligase 1 |
US14/107,053 US9216205B2 (en) | 2012-04-02 | 2013-12-16 | Modified polynucleotides encoding granulysin |
US14/107,029 US20140113959A1 (en) | 2012-04-02 | 2013-12-16 | Modified polynucleotides encoding caspase 6 |
US14/170,751 US20140200263A1 (en) | 2012-04-02 | 2014-02-03 | Modified polynucleotides for treating galactosidase, alpha protein deficiency |
US14/170,744 US20140148502A1 (en) | 2012-04-02 | 2014-02-03 | Modified polynucleotides for treating protein deficiency |
US14/171,226 US9061059B2 (en) | 2012-04-02 | 2014-02-03 | Modified polynucleotides for treating protein deficiency |
US14/171,119 US20140179771A1 (en) | 2012-04-02 | 2014-02-03 | Modified polynucleotides for treating dolichyl-phosphate (udp-n-acetylglucosamine) n-acetylglucosaminephosphotransferase 1 (glcnac-1-p transferase) protein deficiency |
US14/171,249 US9089604B2 (en) | 2012-04-02 | 2014-02-03 | Modified polynucleotides for treating galactosylceramidase protein deficiency |
US14/170,910 US20140155474A1 (en) | 2012-04-02 | 2014-02-03 | Modified polynucleotides for treating cystic fibrosis |
US14/170,914 US20140155475A1 (en) | 2012-04-02 | 2014-02-03 | Modified polynucleotides for treating lipase a, lysosomal acid, cholesterol esterase protein deficiency |
US14/170,897 US20140155472A1 (en) | 2012-04-02 | 2014-02-03 | Modified polynucleotides for treating argininosuccinate synthase 1 protein deficiency |
US14/170,903 US20140155473A1 (en) | 2012-04-02 | 2014-02-03 | Modified glucosidase, beta, acid polynucleotides for treating protein deficiency |
US14/171,242 US20140200264A1 (en) | 2012-04-02 | 2014-02-03 | Modified polynucleotides for treating carboxypeptidase n, polypeptide 1 protein deficiency |
US14/170,747 US20140194494A1 (en) | 2012-04-02 | 2014-02-03 | Modified polynucleotides for treating protein deficiency |
US14/171,235 US20140206755A1 (en) | 2012-04-02 | 2014-02-03 | Modified polynucleotides for treating arylsulfatase a protein deficiency |
US14/280,867 US20140275229A1 (en) | 2012-04-02 | 2014-05-19 | Modified polynucleotides encoding udp glucuronosyltransferase 1 family, polypeptide a1 |
IL232749A IL232749A0 (en) | 2011-12-16 | 2014-05-22 | Modified nucleoside, nucleotide, and nucleic acid compositions |
ZA2014/03783A ZA201403783B (en) | 2011-12-16 | 2014-05-23 | Modified nucleoside, nucleotide, and nucleic acid compositions |
HK15103589.4A HK1203077A1 (en) | 2011-12-16 | 2015-04-13 | Modified nucleoside, nucleotide, and nucleic acid compositions |
US14/694,357 US9283287B2 (en) | 2012-04-02 | 2015-04-23 | Modified polynucleotides for the production of nuclear proteins |
US14/750,004 US9828416B2 (en) | 2012-04-02 | 2015-06-25 | Modified polynucleotides for the production of secreted proteins |
US14/975,141 US9504734B2 (en) | 2012-04-02 | 2015-12-18 | Modified polynucleotides for the production of nuclear proteins |
US15/015,684 US9587003B2 (en) | 2012-04-02 | 2016-02-04 | Modified polynucleotides for the production of oncology-related proteins and peptides |
US15/060,707 US9782462B2 (en) | 2012-04-02 | 2016-03-04 | Modified polynucleotides for the production of proteins associated with human disease |
US15/174,219 US20160289674A1 (en) | 2012-04-02 | 2016-06-06 | Modified polynucleotides for the production of membrane proteins |
US15/425,813 US10501513B2 (en) | 2012-04-02 | 2017-02-06 | Modified polynucleotides for the production of oncology-related proteins and peptides |
US15/440,523 US20180086807A1 (en) | 2012-04-02 | 2017-02-23 | Modified polynucleotides for the production of proteins associated with human disease |
US16/665,985 US20210115101A1 (en) | 2012-04-02 | 2019-10-28 | Modified polynucleotides for the production of proteins associated with human disease |
US16/707,998 US20200247861A1 (en) | 2012-04-02 | 2019-12-09 | Modified polynucleotides for the production of oncology-related proteins and peptides |
US16/860,121 US20220273555A1 (en) | 2012-04-02 | 2020-04-28 | Modified polynucleotides for the production of membrane proteins |
Applications Claiming Priority (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161576705P | 2011-12-16 | 2011-12-16 | |
US61/576,705 | 2011-12-16 | ||
US201261618957P | 2012-04-02 | 2012-04-02 | |
US61/618,957 | 2012-04-02 | ||
US201261648244P | 2012-05-17 | 2012-05-17 | |
US61/648,244 | 2012-05-17 | ||
US201261681712P | 2012-08-10 | 2012-08-10 | |
US61/681,712 | 2012-08-10 | ||
US201261696381P | 2012-09-04 | 2012-09-04 | |
US61/696,381 | 2012-09-04 | ||
US201261709303P | 2012-10-03 | 2012-10-03 | |
US61/709,303 | 2012-10-03 | ||
USPCT/US2012/058519 | 2012-10-03 | ||
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