WO2013078575A8 - 5，7-孕甾二烯-3，20-二酮-二乙二缩酮新的制备方法 - Google Patents

5，7-孕甾二烯-3，20-二酮-二乙二缩酮新的制备方法 Download PDF

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Publication number
WO2013078575A8
WO2013078575A8 PCT/CN2011/002022 CN2011002022W WO2013078575A8 WO 2013078575 A8 WO2013078575 A8 WO 2013078575A8 CN 2011002022 W CN2011002022 W CN 2011002022W WO 2013078575 A8 WO2013078575 A8 WO 2013078575A8
Authority
WO
WIPO (PCT)
Prior art keywords
compound
pregnadiene
dione
diethyl ketal
new preparation
Prior art date
Application number
PCT/CN2011/002022
Other languages
English (en)
French (fr)
Other versions
WO2013078575A1 (zh
WO2013078575A9 (zh
Inventor
张建设
王琛琳
陈济谷
Original Assignee
台州市海盛化工有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 台州市海盛化工有限公司 filed Critical 台州市海盛化工有限公司
Priority to PCT/CN2011/002022 priority Critical patent/WO2013078575A1/zh
Priority to CN201180045623.5A priority patent/CN103314004B/zh
Publication of WO2013078575A1 publication Critical patent/WO2013078575A1/zh
Publication of WO2013078575A8 publication Critical patent/WO2013078575A8/zh
Publication of WO2013078575A9 publication Critical patent/WO2013078575A9/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
    • C07J15/005—Retrosteroids (9 beta 10 alfa)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16

Abstract

公开了5，7-孕甾二烯-3，20-二酮-二乙二缩酮的制备方法，该制备方法是从孕酮出发经过乙二醇脱水缩合保护二个羰基得到化合物B，烯丙位选择性氧化得到化合物D，与对甲苯磺酰肼缩合得到化合物E，通过Shapiro反应脱腙得到5，7-孕甾二烯-3，20-二酮-二乙二缩酮（化合物A）。
PCT/CN2011/002022 2011-12-02 2011-12-02 5，7-孕甾二烯-3，20-二酮-二乙二缩酮新的制备方法 WO2013078575A1 (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/CN2011/002022 WO2013078575A1 (zh) 2011-12-02 2011-12-02 5，7-孕甾二烯-3，20-二酮-二乙二缩酮新的制备方法
CN201180045623.5A CN103314004B (zh) 2011-12-02 2011-12-02 5,7-孕甾二烯-3,20-二酮-二乙二缩酮新的制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2011/002022 WO2013078575A1 (zh) 2011-12-02 2011-12-02 5，7-孕甾二烯-3，20-二酮-二乙二缩酮新的制备方法

Publications (3)

Publication Number Publication Date
WO2013078575A1 WO2013078575A1 (zh) 2013-06-06
WO2013078575A8 true WO2013078575A8 (zh) 2013-07-18
WO2013078575A9 WO2013078575A9 (zh) 2013-12-05

Family

ID=48534576

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2011/002022 WO2013078575A1 (zh) 2011-12-02 2011-12-02 5，7-孕甾二烯-3，20-二酮-二乙二缩酮新的制备方法

Country Status (2)

Country Link
CN (1) CN103314004B (zh)
WO (1) WO2013078575A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016154772A1 (zh) * 2015-04-02 2016-10-06 台州市海盛制药有限公司 9β，10α-孕甾-4，6-二烯-3，20-二酮的制备方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104237417B (zh) * 2014-09-30 2017-06-23 华润紫竹药业有限公司 一种地屈孕酮中间体的分析方法
CN105669813B (zh) * 2015-12-31 2017-11-07 厦门金达威维生素有限公司 一种维生素d3中间体7‑酮胆固醇乙酸酯的合成方法
CN110790808B (zh) * 2019-11-19 2022-10-28 湖南新合新生物医药有限公司 一种5,7-孕甾二烯-3,20-二酮-二乙二缩酮的制备方法
CN112876530A (zh) * 2019-11-29 2021-06-01 重庆乾泰生物医药有限公司 一种地屈孕酮中间体的晶型及其制备方法
CN113880904B (zh) * 2020-07-01 2024-04-12 苏州朗科生物技术股份有限公司 合成地屈孕酮的新方法及化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3014030A (en) * 1959-08-19 1961-12-19 Upjohn Co 9alpha-methylpregnenes, pregnadienes and intermediates therefor
ATE26840T1 (de) * 1982-01-14 1987-05-15 Duphar Int Res Verfahren zur herstellung von delta 5,7 steroiden.
WO2011073419A1 (en) * 2009-12-18 2011-06-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) New steroid inhibitors of pgp for use for inhibiting multidrug resistance

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016154772A1 (zh) * 2015-04-02 2016-10-06 台州市海盛制药有限公司 9β，10α-孕甾-4，6-二烯-3，20-二酮的制备方法

Also Published As

Publication number Publication date
WO2013078575A1 (zh) 2013-06-06
CN103314004B (zh) 2015-07-08
WO2013078575A9 (zh) 2013-12-05
CN103314004A (zh) 2013-09-18

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