WO2013077506A1 - 고강도 집속 초음파용 트랜스듀서 - Google Patents
고강도 집속 초음파용 트랜스듀서 Download PDFInfo
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- WO2013077506A1 WO2013077506A1 PCT/KR2012/002803 KR2012002803W WO2013077506A1 WO 2013077506 A1 WO2013077506 A1 WO 2013077506A1 KR 2012002803 W KR2012002803 W KR 2012002803W WO 2013077506 A1 WO2013077506 A1 WO 2013077506A1
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- Prior art keywords
- transducer
- hifu
- ultrasonic
- attached
- partition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/30—Surgical robots
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0056—Beam shaping elements
- A61N2007/0065—Concave transducers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0078—Ultrasound therapy with multiple treatment transducers
Definitions
- One embodiment of the present invention relates to a transducer for High Intensity Focused Ultrasound (hereinafter referred to as HIFU). More specifically, the present invention relates to a HIFU transducer that can improve the treatment efficiency and stability of HIFU treatment by changing its shape and structure, and improve the efficiency of the manufacturing process or maintenance of the transducer.
- HIFU High Intensity Focused Ultrasound
- HIFU treatment device uses ultrasound and penetrability and focus of ultrasound as a source of energy.
- HIFU is radiated through the skin from a transducer comprising a delivery medium to cancerous tissue in the human body.
- a transducer comprising a delivery medium to cancerous tissue in the human body.
- the ultrasound beam is focused within the tissue and is a roughly grain-shaped focal region (approximately 3 mm ⁇ 8 mm) with an intensity level above 0.1 W / cm 2 . Size) is formed.
- the temperature rises instantaneously (within 0.1 to 5 seconds) (more than 70 degrees Celsius).
- This thermal effect destroys cancer cells in the focal region and finally necrosis and destroys the entire cancer tissue, thereby realizing the purpose of treatment.
- an ultrasonic vibrator capable of delivering an ultrasound beam of 1,000 to 10,000 W / cm 2 to a focus area is used, in contrast to diagnostic imaging ultrasound having an intensity level lower than 0.1 W / cm 2 .
- Some energy of HIFU generated from this ultrasonic vibrator is transferred to the target area as thermal energy.
- the amount of thermal energy delivered in this way can be supplied sufficiently strong to cauterize or necrosis the undesirable tissue by causing the tissue to rise to a temperature above 70 degrees Celsius without actually burning it.
- the focal region can be strictly controlled to obtain necrosis of abnormal tissue or undesirable tissue of a small target region without damaging adjacent normal tissue.
- Necrosis of tissue can also be achieved by mechanical action alone (ie, by the formation of cavities that lead to mechanical destruction of the tissue structure).
- hemostasis may be performed using HIFU.
- HIFU treatment is non-invasive.
- HIFU can destroy cancer in the heart without surgery on the cancer site.
- HIFU can provide additional methods of treatment that do not contradict this tendency by providing noninvasive surgical methods.
- HIFU allows for transcutaneous treatment without incision, thereby avoiding blood loss and risk of infection.
- HIFU treatment does not require anesthesia, reducing the complexity and cost of surgery.
- Such HIFU treatment may be performed on hospital patients, and the greatest advantage is that the health care costs are further reduced while the convenience of the patients is improved.
- the transducer provided in the treatment apparatus using the HIFU generates the HIFU, which is the physical vibration energy, by the ultrasonic vibrator under the control of the control device, and irradiates the HIFU to the treatment area inside the human body to be treated.
- the transducer can be positioned in close proximity to the treatment area through manual positioning by the operator or automatic positioning via robotic arm mechanisms.
- the HIFU can be output from the transducer to a treatment area of about tens to hundreds of watts.
- a treatment area of about tens to hundreds of watts.
- the treatment area is heated to a high temperature (eg, 70 degrees Celsius or more), which is cauterized and treatment is performed.
- FIG. 1 is a partial cross-sectional view of an example of a transducer used in the aforementioned HIFU treatment devices.
- the ultrasonic vibrator 101 of the transducer 100 is provided with an ultrasonic radiating surface 102 having a substantially hemispherical shape.
- the transducer 100 includes a substantially hemispherical membrane 103 having a sealing device 104 formed at an end thereof to be hermetically connected to the ultrasonic vibrator 101.
- the membrane 103 covers and closes the ultrasonic radiating surface 102 of the ultrasonic vibrator 101.
- the ultrasonic radiating surface 102 is formed in a hemispherical concave shape having a focal length radius for physical focusing of ultrasonic energy.
- the ultrasonic delivery medium is filled between the membrane 103 and the ultrasonic radiating surface 102.
- Unexplained reference numeral 105 denotes a push ring for connecting the membrane 103 to the ultrasonic vibrator 101.
- a probe 120 connected to an ultrasound imaging apparatus (not shown) and collecting image data may be installed in the transducer 100.
- the ultrasonic delivery medium may be water deaired.
- One of the important components of all types of HIFU treatment devices is the means of coupling ultrasound energy into tissue. Good acoustic coupling is required to efficiently transfer ultrasonic energy from the ultrasonic vibrator 101 to the treatment area.
- An ideal acoustic coupler is a homogenous medium with the same low attenuation and acoustic impedance as the tissue. Water has been commonly used as ultrasonic delivery medium in many HIFU therapeutic fields for desirable acoustic transmission properties.
- Membrane 103 has a similar acoustic impedance to water and is made of a material having low ultrasonic wave transmission loss, perfect thermal conductivity, and good elasticity, such as latex, relatively soft natural rubber, silicone rubber, and the like.
- the transducer 100 is made by concave processing of the ultrasonic vibrator 101 using a focal length as a radius for physical focusing of ultrasonic energy.
- the transducer is made by attaching an ultrasonic vibrator in the form of tens or hundreds of disks or polygonal plates to a concave frame having a focal length radius.
- Such transducers are referred to as so-called array transducers, and by utilizing them, the ultrasonic focusing positions may be varied by inputting electrical signals having different phases to each of the attached ultrasonic vibrators (with piezoelectric elements). That is, the arrayed transducer can vary a single focal point or generate multiple focal points by electric steering alone. Therefore, since the mechanical movement of the transducer is not required to treat a wide range of areas, the treatment system is simplified and the treatment time can be shortened.
- FIG. 2A to 2D schematically show conventional examples of the array transducer, which are distinguished as follows according to the arrangement form of the ultrasonic vibrator.
- FIG. 2A shows the ultrasonic vibrator 201 arranged in an angular form on the concave surface of the transducer 200
- FIG. 2B shows an arrangement arranged in an annular shape
- FIG. 2C shows an elliptical arrangement
- Figure 2d shows a form arranged in a random (Random) type.
- the arrayed transducer 200 having the ultrasonic vibrator array of the type described above has the disadvantage that a point where unintended ultrasonic energy is focused in a region other than the focus. Focusing in this unintended area is called a grating lobe, which can cause local heating in the unintended area upon HIFU treatment. Heating by such a grating lobe causes serious problems as one of the side effects that frequently occur during HIFU treatment.
- the present invention provides a HIFU transducer that can increase the steering range by reducing the size of the grating lobe generated during electrical steering while also compensating for the problem of low focus gain by changing the arrangement of the ultrasonic vibrator on the transducer.
- the purpose is to provide.
- another object of the present invention by forming a frame of the transducer into a plurality of divided parts and modifying them into a split type to form a single transducer in combination, thereby reducing the defect rate of the transducer during manufacturing, the future ultrasonic vibrator When the breakdown occurs, only the partition containing the failed ultrasonic vibrator can be replaced and used to provide a transducer for HIFU, which can improve the efficiency of the manufacturing process or maintenance of the transducer.
- HIFU transducer in one HIFU transducer having a concave frame, a plurality of ultrasonic vibrators attached to the frame, the frame is formed of a plurality of partitions And the plurality of ultrasonic vibrators are attached on the concave surface of the respective divisions.
- the ultrasonic vibrator is characterized in that it is attached in a different arrangement for each partition.
- the transducer for HIFU is characterized in that the ultrasonic vibrator is regularly arranged in the at least one division, and is randomly arranged and attached to the at least one division.
- the transducer for HIFU is characterized in that the ultrasonic vibrator is randomly arranged in each of the divisions, and the arrangement is equally applied to all the divisions.
- the transducer for HIFU is characterized in that the ultrasonic vibrators are arranged randomly in each of the divisions, and the arrangement is applied to each of the divisions in the same manner.
- the transducer by converting the transducer into a split type, it is possible to reduce the defective rate of the transducer during manufacturing, and to replace and use only the divided part including the failed ultrasonic vibrator when a failure occurs in the ultrasonic vibrator in the future, The effect is expected to improve the efficiency of the transducer manufacturing process or maintenance.
- FIG. 1 is a partial cross-sectional view of an example of a transducer used in prior art HIFU treatment devices.
- FIG. 2 is a schematic view showing conventional examples of an array transducer, but showing an arrangement of the ultrasonic vibrators.
- FIG. 2 is a schematic view showing conventional examples of an array transducer, but showing an arrangement of the ultrasonic vibrators.
- FIG 3 is a schematic bottom view of a transducer according to a first embodiment of the present invention.
- FIG. 4 is a schematic bottom view of a transducer according to a second embodiment of the present invention.
- FIG. 5 is a schematic bottom view of a transducer according to a third embodiment of the present invention.
- FIG. 6 is a schematic bottom view of a transducer according to a fourth embodiment of the present invention.
- FIG. 7 is a schematic bottom view illustrating a modification of the transducer illustrated in FIG. 5.
- FIG. 8 is an exploded perspective view showing the assembly of the transducer shown in FIG.
- the HIFU transducer according to the present invention is a HIFU transducer having a concave frame on one side and a plurality of ultrasonic vibrators attached to the frame, wherein the frame is formed of a plurality of divisions. .
- Each segment constituting the frame may be formed from a variety of heat sinks to provide non-invasive treatment, for example made of a metal such as aluminum or a material such as plastic.
- Each division may be a surface having a concave shape on one side thereof.
- the shape of each division and ultimately the frame is not limited thereto, and may be formed in various shapes that may be directly or indirectly contacted with a patient to allow treatment while having a plurality of ultrasonic vibrators described below.
- a plurality of ultrasonic vibrators may be attached to one concave side surface of each division part. Since the installation method of the ultrasonic vibrator is already known technology, a detailed description thereof will be omitted, and only the arrangement of the ultrasonic vibrators will be described.
- the ultrasonic vibrator may include a piezoelectric element and one or more acoustic matching layers positioned on one side of the piezoelectric element to appropriately form resonance characteristics.
- the signal line may be connected to transmit an electrical signal supplied from the ultrasonic generator to the piezoelectric element and to receive the signal from the piezoelectric element.
- the piezoelectric element may be made of piezoelectric materials such as piezoelectric ceramics, crystals, composite materials and the like, for example, PZT (Lead Zirconate Titanate).
- the signal lines may be configured in the form of wires or terminal pins, and may be arranged and connected in various ways (including not only physical connections but also electrical connections), and thus detailed description thereof will be omitted.
- a plurality of ultrasonic vibrators may be arranged in various arrangements in each division constituting the frame.
- FIG. 3 is a schematic bottom view of a transducer according to a first embodiment of the present invention.
- the ultrasonic vibrator 301 is attached to each partition in a different arrangement.
- a plurality of ultrasonic vibrators 301 may be arranged in a regular annular arrangement in the first division part 310a corresponding to the first quadrant, and correspond to the second quadrant.
- the second division part 310b is a random arrangement
- the third division part 310c corresponding to the third quadrant has an angular arrangement
- Each segment can be tailored or adjusted to have a different distinct focus area.
- FIG. 3 On the right side of FIG. 3 is a graph showing the intensity of the grating lobe generated when the ultrasonic wave is steered.
- a red dot having a grating lobe having an intensity value (I Grating ) of less than 0.1 ⁇ peak intensity (I Peak ) is widely distributed.
- I Grating intensity value
- I Peak peak intensity
- the more red dots are located in the area of the graph corresponding to -3 dB (when the power of an ultrasonic wave is halved), the better.
- the strength of the grating lobe becomes much weaker than that of the conventional transducer.
- FIG. 4 is a schematic bottom view of a transducer according to a second embodiment of the present invention.
- the ultrasonic vibrator 301 is regularly arranged in at least one partition, and at least one partition is random Can be arranged and attached.
- a plurality of ultrasonic vibrators 301 are arranged in a regular annular arrangement in the first division part 310a corresponding to the first quadrant and the third division part 310c corresponding to the third quadrant. It may be arranged, and may be attached to the second divided portion 310b corresponding to the second quadrant and the fourth divided portion 310d corresponding to the fourth quadrant.
- first division part 310a and the third division part 310c are attached in a random arrangement, and the second division part 310b and the fourth division part 310d are arranged in a regular arbitrary shape. May be attached.
- a random arrangement may be alternately positioned in another adjacent division.
- the regular array structure and the random array structure may be positioned while being periodically repeated.
- the quality of the steering can be seen that the intensity of the grating lobe is higher in the transducer in which the ultrasonic vibrators 301 are arranged in FIG. 4 than in the transducer in which the ultrasonic vibrators 301 are arranged in FIG. It can be seen that it is in a better arrangement (because the number of red dots is more and more widely distributed).
- FIG. 5 is a schematic bottom view of a transducer according to a third embodiment of the present invention.
- the ultrasonic vibrator 301 is arranged randomly in each division, the same random arrangement is the same in all divisions Is applied.
- a plurality of ultrasonic vibrators 301 are attached to the first division part 310a corresponding to the first quadrant in a random arrangement.
- the arrangement is the second division part 310b and the third division.
- This structure is different from the random arrangement of FIG. 2D described above.
- the frame of the transducer is divided, and in FIG. 2D, the entire array of ultrasonic vibrators is randomly configured without any regularity, but FIG. 5 shows that the arrangement structure of one division unit is repeated as many as the remaining divisions. Is to have regularity.
- FIG. 6 is a schematic bottom view of a transducer according to a fourth embodiment of the present invention.
- the ultrasonic vibrator 301 is arranged randomly in each division, the arrangement is equal to each other part of the division It is characterized by the application.
- a plurality of ultrasonic vibrators 301 are attached to the first division part 310a corresponding to the first quadrant in a first random arrangement, and the arrangement is attached to the third division part 310c. Will be applied.
- the arrangement may be applied to the fourth division part 310d.
- the second random arrangement may be alternately positioned in another adjacent division.
- the first random array and the second random array may be positioned periodically.
- This structure also differs from the random arrangement of FIG. 2D described above.
- the frame of the transducer is divided, and in FIG. 2D, the entire array of ultrasonic vibrators is randomly configured without any regularity.
- FIG. 6 at least one pair of divisions are repeatedly attached to each other in the same random arrangement. Is to have a last name.
- the expression of the grating lobe can be minimized to effectively transfer energy from the ultrasonic vibrator to the intended treatment area to be maintained to achieve an appropriate temperature increase, thereby efficiently obtaining the desired treatment result.
- FIG. 7 is a schematic bottom view illustrating a modified example of the transducer according to the third embodiment shown in FIG. 5.
- a plurality of ultrasonic vibrators 301 are attached to the first splitting unit 310a in a random arrangement.
- Such an arrangement structure includes a second splitting unit 310b and a third splitting unit 310c.
- the fourth division 310d ... the same applies to the eighth division 310h. Therefore, this modification is an example showing that the number of divisions constituting the transducer 300 can be changed.
- the number of divisions is about 4-8. If the number of partitions is too large, it is not appropriate because the manufacturing and assembly process is so expensive and time-consuming.
- FIG. 8 is an exploded perspective view showing the assembly of the transducer shown in FIG. 7.
- a manufacturing method of the HIFU transducer according to the present invention will be described with reference to FIG. 8.
- the transducer 300 includes a plurality of divided portions 310 having one side concave, an outer ring 321 supporting and fixing the divided portions 310, and an inner diameter of the outer ring 321 while supporting and fixing the divided portions 310.
- An inner ring 322 that is spaced apart from the outer ring 321 with a much smaller outer diameter, and a retaining ring that is held to prevent radial detachment of the segments 310 while surrounding the outer circumferential surface of the segments 310. 330 is included.
- each division part 310 has a plurality of ultrasonic vibrators 301 attached to a concave surface, and a plurality of terminal pins 302 constituting a signal line are opposite to the ultrasonic vibrators 301. Stretched.
- the ultrasonic wave vibrator 301 including the dividing unit 310 and the piezoelectric element having a predetermined acoustic matching layer is separately manufactured, and the ultrasonic vibrator 310 is fixed to the dividing unit 310 by bonding or the like. After the terminal pin 302 is electrically connected to the ultrasonic vibrator 301.
- the terminal pin 302 is divided by passing through the space between the outer ring 321 and the inner ring 322 when the partition 310 is supported and fixed on the outer ring 321 and the inner ring 322. It is electrically connected to and fixed to a PCB (not shown) located on the opposite side of the installment 310.
- the partition 310 may be supported and fixed on the outer ring 321 and the inner ring 322 by using fasteners such as bolts, snap fasteners, or even adhesives.
- the outer ring 321 and the inner ring 322 may be formed integrally via a connecting piece (not shown) connecting them, but is not necessarily limited to this may be formed to be separated.
- the retaining ring 330 is press-fitted to the outer circumferential surfaces of the divided portions 310 positioned on the outer ring 321 and the inner ring 322.
- the outer ring 321 and the inner ring 322 and the retaining ring 330 may be made of a material such as metal or plastic, such as stainless steel, the diameter and thickness of the outer ring 321 corresponding to the divided portion 310 Of course, it can be changed appropriately.
- the frame of the transducer 300 is converted into a split type having a plurality of dividers 310, thereby reducing the defective rate of the transducer during manufacturing and including a failed ultrasonic vibrator when a failure occurs in the ultrasonic vibrator in the future. Only the divider can be replaced, which improves the efficiency of the manufacturing process or maintenance of the transducer.
- Transducer 300 formed in the above-described structure the HIFU is irradiated to the treatment area of the human body through manual position adjustment by the operator or automatic position adjustment via a robotic arm mechanism (not shown).
- the robotic arm mechanism includes an arm that is coupled to the transducer 300 to operate electrically and mechanically.
- the transducer 300 can be installed in a manner such as bolting, chucking, clamping, or the like.
- the HIFU transducer 300 may further include an imaging probe (not shown) installed in the inner inner ring 322.
- the imaging probe includes a beam forming control unit.
- the imaging probe is operative to scan the region of interest including the treatment region of the human body with ultrasound.
- the returned signal is received by the imaging probe and then transmitted to the beamforming control unit to generate an ultrasound image of the region of interest including the treatment region.
- the resulting image can then be displayed on a display (not shown) to assist the operator in properly positioning the transducer 300 relative to the treatment area prior to starting the actual treatment.
- the present specification has been described mainly for the transducer for the treatment, it is to be understood that the present invention is not limited to this use.
- the HIFU transducer according to the present invention can be applied to other industries.
Abstract
Description
Claims (10)
- 일측면이 오목한 프레임과, 상기 프레임에 부착되는 다수의 초음파 진동자를 구비한 HIFU용 트랜스듀서에 있어서,상기 프레임이 다수의 분할부로 형성되고,상기 다수의 초음파 진동자가 상기 각 분할부의 오목한 표면상에 부착되는 것을 특징으로 하는 HIFU용 트랜스듀서.
- 제1항에 있어서,상기 초음파 진동자는 상기 각 분할부마다 서로 다른 배열구조로 부착되는 것을 특징으로 하는 HIFU용 트랜스듀서.
- 제1항에 있어서,상기 초음파 진동자가 상기 적어도 하나의 분할부에서는 규칙적으로 배열되고, 상기 적어도 다른 하나의 분할부에서는 랜덤식으로 배열되어 부착되는 것을 특징으로 하는 HIFU용 트랜스듀서.
- 제1항에 있어서,상기 초음파 진동자가 상기 각 분할부에서 랜덤식으로 배열되되, 그 배열이 모든 분할부에서 동일하게 적용되는 것을 특징으로 하는 HIFU용 트랜스듀서.
- 제1항에 있어서,상기 초음파 진동자가 상기 각 분할부에서 랜덤식으로 배열되되, 그 배열이 일부 분할부끼리 서로 동일하게 적용되는 것을 특징으로 하는 HIFU용 트랜스듀서.
- 제1항에 있어서,상기 분할부의 개수는 4 ~ 8개인 것을 특징으로 하는 HIFU용 트랜스듀서.
- 제1항에 있어서,상기 트랜스듀서는, 상기 분할부를 지지 고정하는 외측링, 상기 분할부를 지지 고정하면서 상기 외측링의 내경보다 작은 외경을 가진 내측링, 및 상기 분할부의 외주면을 둘러싸면서 상기 분할부를 보유지지하는 유지링을 더 포함하는 것을 특징으로 하는 HIFU용 트랜스듀서.
- 제7항에 있어서,상기 각 분할부는 상기 초음파 진동자들의 반대쪽으로 신호라인을 구성하는 다수의 단자핀이 뻗어 있는 것을 특징으로 하는 HIFU용 트랜스듀서.
- 제8항에 있어서,상기 단자핀은, 상기 분할부가 상기 외측링과 상기 내측링 상에 지지 고정될 때, 상기 외측링과 상기 내측링 사이의 공간을 통과하여 상기 분할부의 반대측에 위치하는 PCB에 연결 고정되는 것을 특징으로 하는 HIFU용 트랜스듀서.
- 제1항 내지 제9항 중 어느 한 항에 있어서,상기 트랜스듀서는 로보틱 아암 기구의 아암의 끝에 설치되는 것을 특징으로 하는 HIFU용 트랜스듀서.
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KR1020110121683A KR101355532B1 (ko) | 2011-11-21 | 2011-11-21 | 고강도 집속 초음파용 트랜스듀서 |
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