WO2013059281A3 - Procédés de préparation de nouveaux dérivés de benzimidazole - Google Patents

Procédés de préparation de nouveaux dérivés de benzimidazole Download PDF

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Publication number
WO2013059281A3
WO2013059281A3 PCT/US2012/060560 US2012060560W WO2013059281A3 WO 2013059281 A3 WO2013059281 A3 WO 2013059281A3 US 2012060560 W US2012060560 W US 2012060560W WO 2013059281 A3 WO2013059281 A3 WO 2013059281A3
Authority
WO
WIPO (PCT)
Prior art keywords
processes
preparation
benzimidazole derivatives
novel benzimidazole
intermediates
Prior art date
Application number
PCT/US2012/060560
Other languages
English (en)
Other versions
WO2013059281A2 (fr
Inventor
Datong Tang
Guoyou Xu
Xiaowen Peng
Lu Ying
Ce Wang
Hui Cao
Jiang Long
In Jong Kim
Guoqiang Wang
Yao-Ling Qiu
Yat Sun Or
Original Assignee
Enanta Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharmaceuticals, Inc. filed Critical Enanta Pharmaceuticals, Inc.
Priority to MX2014004705A priority Critical patent/MX2014004705A/es
Priority to EP12842330.8A priority patent/EP2768825A2/fr
Priority to AU2012326239A priority patent/AU2012326239A1/en
Priority to BR112014009222A priority patent/BR112014009222A8/pt
Priority to KR1020147012946A priority patent/KR20140079830A/ko
Priority to EA201400475A priority patent/EA201400475A1/ru
Priority to CN201280062444.7A priority patent/CN104302642A/zh
Priority to CA2852900A priority patent/CA2852900A1/fr
Publication of WO2013059281A2 publication Critical patent/WO2013059281A2/fr
Priority to US14/253,976 priority patent/US8921573B2/en
Publication of WO2013059281A3 publication Critical patent/WO2013059281A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Cette invention concerne des procédés et des intermédiaires pour la préparation de nouveaux dérivés de benzimidazole, notamment dans la synthèse d'inhibiteurs de la NS5A du virus de l'hépatite C. En particulier, cette invention concerne des procédés et des intermédiaires pour la préparation de composés de formule (I-a) :
PCT/US2012/060560 2011-10-18 2012-10-17 Procédés de préparation de nouveaux dérivés de benzimidazole WO2013059281A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
MX2014004705A MX2014004705A (es) 2011-10-18 2012-10-17 Procedimientos para la preparacion de derivados de bencimidazol novedosos.
EP12842330.8A EP2768825A2 (fr) 2011-10-18 2012-10-17 Procédés de préparation de nouveaux dérivés de benzimidazole
AU2012326239A AU2012326239A1 (en) 2011-10-18 2012-10-17 Processes for the preparation of novel benzimidazole derivatives
BR112014009222A BR112014009222A8 (pt) 2011-10-18 2012-10-17 processos para a preparação de novos derivados de benzimidazol
KR1020147012946A KR20140079830A (ko) 2011-10-18 2012-10-17 신규한 벤즈이미다졸 유도체의 제조 방법
EA201400475A EA201400475A1 (ru) 2011-10-18 2012-10-17 Способы получения новых производных бензимидазола
CN201280062444.7A CN104302642A (zh) 2011-10-18 2012-10-17 制备新的苯并咪唑衍生物的方法
CA2852900A CA2852900A1 (fr) 2011-10-18 2012-10-17 Procedes de preparation de nouveaux derives de benzimidazole
US14/253,976 US8921573B2 (en) 2011-10-18 2014-04-16 Processes for the preparation of novel benzimidazole derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161548374P 2011-10-18 2011-10-18
US61/548,374 2011-10-18

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/253,976 Continuation US8921573B2 (en) 2011-10-18 2014-04-16 Processes for the preparation of novel benzimidazole derivatives

Publications (2)

Publication Number Publication Date
WO2013059281A2 WO2013059281A2 (fr) 2013-04-25
WO2013059281A3 true WO2013059281A3 (fr) 2015-06-18

Family

ID=48141609

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/060560 WO2013059281A2 (fr) 2011-10-18 2012-10-17 Procédés de préparation de nouveaux dérivés de benzimidazole

Country Status (10)

Country Link
US (1) US8921573B2 (fr)
EP (1) EP2768825A2 (fr)
KR (1) KR20140079830A (fr)
CN (1) CN104302642A (fr)
AU (1) AU2012326239A1 (fr)
BR (1) BR112014009222A8 (fr)
CA (1) CA2852900A1 (fr)
EA (1) EA201400475A1 (fr)
MX (1) MX2014004705A (fr)
WO (1) WO2013059281A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8673954B2 (en) * 2009-02-27 2014-03-18 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
US9765087B2 (en) * 2009-02-27 2017-09-19 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
US10752611B2 (en) 2009-02-27 2020-08-25 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
WO2015096674A1 (fr) * 2013-12-23 2015-07-02 南京圣和药业股份有限公司 Inhibiteur du virus de l'hépatite c et ses utilisations
CN104788361B (zh) * 2015-04-21 2017-06-30 杭州科巢生物科技有限公司 5‑氮杂螺[2.4]庚烷‑6‑甲酸衍生物的合成方法
CN106008316B (zh) * 2016-06-17 2018-04-27 成都百事兴科技实业有限公司 一种合成雷迪帕韦手性中间体的方法
CN114957145B (zh) * 2022-04-14 2023-07-18 浙江师范大学 一种1,2,4-苯并三嗪衍生物及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0550025A1 (fr) * 1991-12-31 1993-07-07 Korea Research Institute Of Chemical Technology Azaspiroheptanes et octanes et procédés pour leur production
US20070275897A1 (en) * 2006-05-26 2007-11-29 Raines Ronald T Collagen mimics
US20090270637A1 (en) * 2005-09-28 2009-10-29 Daiichi Sankyo Company, Limited Process for preparation of tetrasubstituted 5-azaspiro[2.4]- heptane derivatives and optically active intermediates thereof
US20100233122A1 (en) * 2009-02-27 2010-09-16 Yao-Ling Qiu Novel benzimidazole derivatives
WO2011031904A1 (fr) * 2009-09-11 2011-03-17 Enanta Pharmaceuticals, Inc Inhibiteurs du virus de l'hépatite c

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI438200B (zh) * 2009-02-17 2014-05-21 必治妥美雅史谷比公司 Ｃ型肝炎病毒抑制劑

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0550025A1 (fr) * 1991-12-31 1993-07-07 Korea Research Institute Of Chemical Technology Azaspiroheptanes et octanes et procédés pour leur production
US20090270637A1 (en) * 2005-09-28 2009-10-29 Daiichi Sankyo Company, Limited Process for preparation of tetrasubstituted 5-azaspiro[2.4]- heptane derivatives and optically active intermediates thereof
US20070275897A1 (en) * 2006-05-26 2007-11-29 Raines Ronald T Collagen mimics
US20100233122A1 (en) * 2009-02-27 2010-09-16 Yao-Ling Qiu Novel benzimidazole derivatives
WO2011031904A1 (fr) * 2009-09-11 2011-03-17 Enanta Pharmaceuticals, Inc Inhibiteurs du virus de l'hépatite c

Also Published As

Publication number Publication date
BR112014009222A2 (pt) 2017-06-13
US20140316143A1 (en) 2014-10-23
MX2014004705A (es) 2014-10-17
BR112014009222A8 (pt) 2017-06-20
US8921573B2 (en) 2014-12-30
CA2852900A1 (fr) 2013-04-25
WO2013059281A2 (fr) 2013-04-25
EP2768825A2 (fr) 2014-08-27
AU2012326239A1 (en) 2014-05-15
CN104302642A (zh) 2015-01-21
EA201400475A1 (ru) 2014-09-30
KR20140079830A (ko) 2014-06-27

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