WO2013054304A1

WO2013054304A1 - Use of an oral composition including a mixture of a least one polyphenol, zinc, and vitamin c

Info

Publication number: WO2013054304A1
Application number: PCT/IB2012/055551
Authority: WO
Inventors: Nathalie Piccardi; Carole BRU; Yann Mahe; Ahsène CHENITI
Original assignee: Laboratoires Inneov
Priority date: 2011-10-14
Filing date: 2012-10-12
Publication date: 2013-04-18
Also published as: EP2765981A1; FR2981272A1

Abstract

The present invention relates to the cosmetic use, as a soothing agent, of an oral composition including at least: (i) a polyphenol or a mixture of polyphenols; (ii) zinc, preferably in the form of a zinc salt; and (iii) vitamin C.

Description

USE OF AN ORAL COMPOSITION COMPRISING A MIXTURE OF AT LEAST ONE POLYPHENOL, ZINC, AND VITAMIN C.

The present invention relates to uses and methods, in particular cosmetic or pharmaceutical, using an oral composition comprising a mixture of at least one polyphenol, zinc, and vitamin C.

In general, it is desirable to improve the appearance of the skin, beautify the skin, treat imperfections or skin disorders. Such objectives may be pursued in particular to reduce or even avoid certain undesirable effects on the skin caused by (i) various cosmetic or pharmaceutical physical or chemical treatments, or (ii) skin aggressions due to environmental causes.

For purposes of this disclosure, cosmetic treatments include aesthetic treatments.

For the purposes of the invention, topical treatments include topical physical and chemical treatments.

Chemical treatments include oral administration and topical application to the skin or scalp of at least one cosmetic or medical substance.

The physical treatments include treatments comprising a step of exposing the skin or scalp (i) to a mechanical action, for example a step of abrasion of the skin or scalp to cause desquamation or (ii) ) to a source of energy, for example light energy such as UV radiation, infra-red radiation, laser light, pulsed light source, etc. In particular, physical treatments include aesthetic treatments selected from photodynamic therapy using lasers, blue or red lights, intense pulsed light (IPL) or non-intense "gentle waves" type. Physical treatments also include those specifically targeting the sebaceous glands, as described in "Cosmetic Applications of Laser and Ligh Based Systems" (William Andrews Press, Gupreet S. Ahluwalia ed., Chapter 21: Photodynamic Therapy for Acne, rejuvenation and Hair removal. pp399-411; 2009, which includes resurfacing treatments using a laser.

For purposes of this disclosure, the term "treatment" includes the implementation of a method of treatment on a subject. Said method of treatment includes at least one step of administering at least one asset, where appropriate in the form of a composition comprising said asset (s), which (s) is (are) optionally combined with an excipient or a combination of physiologically acceptable excipients.

A "cosmetic treatment" encompasses the implementation of a method of cosmetic treatment on a subject, and comprises at least one step of administering at least one cosmetic active agent, optionally combined with one or more cosmetically acceptable excipients.

"Pharmaceutical treatment" includes the implementation of a method of pharmaceutical treatment on a subject, and comprises at least one step of administering at least one pharmaceutical active ingredient, optionally combined with one or more pharmaceutically acceptable excipients. Pharmaceutical treatments include dermatological treatments. The term "pharmaceutical / dermatological" means "pharmaceutical, especially dermatological".

Skin reactions, including skin irritation, are known to be induced by a variety of exogenous causes, including (i) chemical causes, eg, xenobiotics, antigens, allergens, chemicals, compounds that may cause skin irritation, cosmetic chemical peeling processes, (ii) environmental origin (temperature, climate, UV radiation, atmospheric pollution, especially heavy metals, ozone, cigarette smoke ...) or (iii) of physical origin, including of mechanical origin (friction, shaving).

In particular it is known that skin irritations or cutaneous reactions of discomfort can be induced by certain treatments, which respectively include certain cosmetic treatments and certain pharmaceutical treatments, including certain dermatological treatments, administered topically or orally.

Skin reactions may also manifest as discomfort experienced by the user on the skin. It can typically be redness, itching, heating, burning, tingling, tugging. Cosmetic treatments can remedy this discomfort.

Skin reactions can also be caused by oral pharmaceutical treatments. For example, cutaneous reactions are known, in particular skin discomfort, skin dryness or skin peeling, which may be caused by the oral administration of retinoid compounds.

Skin discomfort can be caused by some topical treatments to limit skin imperfections or disorders, including imperfections or skin disorders associated with acne, associated with oily skin or associated with aging skin.

Acne occurs most often in the youngest teens from the age of 11-12 with a peak of activity around 15-18 years indicating in particular the contribution of sex hormones in its etiology. It can then be expressed throughout life in varying degrees and most often in outbreaks. In parallel with the extent of the affected areas, various stages of the pathology, are described such as follicular hyper proliferation, sebum production, even inflammation as well as activity levels of Propionibacterium acnes. Acne can be classified by the dermatologist since the moderate stages to very severe stages in relation to the types of cutaneous lesions observed such as comedones, papules, pustules nodules or even scars generated. The major treatments for acne or its unsightly aesthetic consequences are topical or systemic retinoids, antibiotics, topical benzoyl peroxide alone or in combination with topical or systemic antibiotic treatments or even in the most extreme cases of treatment with chemical peels or even laser treatments or photodynamic therapy using especially photoactivatable derivatives such as 5-aminolevulinic acid as described in acne vulgaris: lasers, light sources and photodynamic therapy, an update 2007; Michael H Gold, Rev.Anti expert infected. Ther. 5 (6), 1059-1069 (2007).

Oily or hyperseborrhoeic skin is characterized by a shiny skin, sometimes oily in appearance, thick, with enlarged pilosebaceous pores. Sebaceous hypersecretion is most often linked to hyperandrogenism due either to an androgen hyperproduction by an endocrine gland, or to a peripheral hyperproduction notably in the sebaceous gland. This sebaceous hypersecretion, combined with an accumulation of epithelial cells resulting from an abnormal cell multiplication, can lead to an obstruction of the sebaceous follicles, localized especially on the face, which can evolve into comedones. In addition, an anaerobic resident bacterium, Propioni bacterium acnes, proliferates in this environment rich in sebum and follicular cells and may contribute locally to inflammation.

A fatty skin with an acne tendency therefore generally has cutaneous imperfections, dilated pores, an inhomogeneous texture of the skin, redness and a shiny and shiny appearance.

The cosmetic treatment of this type of skin generally involves the topical application to the skin of a mixture of compounds making it possible to act on the various causes of the imperfections and in particular to control the production of sebum (retinoids, zinc salts, cinnamon, ulmary or laminar extracts) and / or to promote desquamation (alpha- and beta-hydroxy acids) and / or to limit microbial growth (iodopropynyl butylcarbamate, triclosan, octoxyglycerine, octanoylglycine).

Mixtures comprising zinc and copper pidolates, in a composition also comprising at least one α-hydroxy acid, at least one algae extract and at least one haloalkynyl carbamate, are also known from patent application EP 1 437 124, for the cosmetic treatment of acne-prone skin. In addition to the expected beneficial effect in terms of curative effect, however, the active ingredients can cause cutaneous intolerance of the skin reaction type of discomfort on the skin.

Also, use is made of cosmetic compositions containing, for example, keratolytic and / or desquamating active ingredients for combating aging, and in particular exfoliating active agents and / or promoting agents for cell renewal, such as α-hydroxy acids (in particular lactic acid, glycolic acid). , citric), β-hydroxyacids

(especially salicylic acid) or retinoids (especially retinoic acids, all trans or 13-cis-retinol-adapalene ...).

In particular circumstances, the use of these active ingredients, for example in high concentrations, may also lead to the appearance of skin irritations or skin reactions of discomfort.

In order to temper the undesirable effects they generate, compounds that can cause skin irritation or skin discomfort can be used in low doses. Alternatively, the treatment must be stopped prematurely. In both cases, it leads to a reduction, sometimes substantial, of the effectiveness of said treatments. In general, there is a need for compositions or methods for reducing or avoiding skin imperfections, skin disorders or discomfort skin.

In particular, there is a need for cosmetic compositions or methods for reducing, partially or totally, alterations or disorders of the skin surface, including skin irregularities, which are caused by physical or chemical treatments. whether in the form of cosmetic treatments or pharmaceutical treatments, or which are caused by affections of the skin, which alterations or irregularities of the skin remain after said disorders are physiologically resolved. By way of illustration, there is a need for cosmetic compositions or methods aimed at reducing, partially or totally, the residual irregularities of the surface of an acneic skin, especially after the treatment of acne has been successfully performed.

There is a need for compositions or methods able to reduce in whole or in part the disadvantages associated with cosmetic or pharmaceutical treatments administered topically or orally, and in particular the cutaneous disadvantages described above, and thus to improve the tolerance of the subjects vis-à-vis these cosmetic or pharmaceutical treatments or increase the effectiveness of such treatments.

In particular, there is a need for cosmetic processes intended to increase the tolerance or effectiveness of cosmetic or pharmaceutical treatments, including dermatological treatments administered topically or orally.

Surprisingly, the inventors have shown that it is possible to reduce certain undesirable effects caused by the implementation of topical cosmetic physical treatments, or by the implementation of cosmetic chemical treatments or chemical pharmaceutical / dermatological treatments, by way of topically or orally, by orally administering a composition comprising at least one combination of polyphenol (s), zinc, and vitamin C. The reduction of undesirable effects caused by these treatments, which is achieved by administering oral composition comprising at least one combination of polyphenol (s), zinc, and vitamin C, allows a better compliance of said treatments by the treated individuals. It is also shown that the reduction of undesirable effects caused by the implementation of the above treatments, through the oral administration of the composition comprising at least one combination of polyphenol (s), zinc, and vitamin C, increases the effectiveness of said treatments.

In particular, it is shown that said undesirable effects are reduced when said oral composition is administered together with said topical physical treatments, said cosmetic applications or said pharmaceutical / dermatological, topical or oral applications.

The inventors have shown in particular that the oral administration of the composition defined above makes it possible to reduce the cutaneous reactions of discomfort caused by cosmetic treatments and certain pharmaceutical treatments, in particular certain dermatological treatments, such as these cosmetic or pharmaceutical treatments. are administered topically or orally.

Disorders and skin imperfections and discomforts include skin reactions such as redness, itching, heat and / or burning sensations, tingling sensation, or tightness.

In particular it is shown according to the invention that the oral administration of a composition as defined above makes it possible to reduce the general discomfort caused by a topical treatment of cutaneous disorders associated with acne.

It has also been shown that the oral administration of a composition as defined above also makes it possible to reduce the general discomfort caused by a treatment of skin imperfections, in particular skin imperfections resulting from hyper-seborrhea. , likely to be accompanied by an obstruction of the pores of the skin.

The present invention relates to the cosmetic use of an oral composition comprising at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt, and (iii) vitamin C as a soothing agent.

In advantageous embodiments, said oral composition also comprises magnesium, preferably in the form of a magnesium salt.

In advantageous embodiments, said oral composition also comprises vitamin B6. For the purposes of the present description, a soothing agent exerts, in particular, a reduction effect, partial or total, of skin discomfort caused by the topical application of a physical treatment, for example exposure of the skin to radiation (UV, IR, pulsed light, laser, etc.) or a topical or oral chemical treatment, that is to say a treatment with at least one cosmetic or pharmaceutical active topically or orally. In particular, a soothing agent may partially or completely reduce the redness, itching, heating, burning sensation, tingling sensations and skin tightness sensations that are caused by said cosmetic or pharmaceutical treatment, topical or oral.

In the present description, the composition comprising at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt, and (iii) vitamin C can also be designated "soothing agent".

In advantageous embodiments, said oral composition, or soothing agent, also comprises magnesium, preferably in the form of a magnesium salt.

In advantageous embodiments, said oral composition, or soothing agent, also comprises vitamin B6.

The invention also relates to a cosmetic method for increasing the tolerance of a subject to a topical or oral cosmetic or dermatological treatment comprising the oral administration of a composition comprising at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt, and (iii) vitamin C.

In advantageous embodiments, said oral composition also comprises vitamin B6.

Thus, the present invention relates to a cosmetic or pharmaceutical process, or a composition for the implementation of such a method, which process increases the tolerance of a subject to a topical or oral cosmetic or dermatological treatment when said process or said composition is able to reduce, partially or totally, the undesirable cutaneous effects caused by said cosmetic or pharmaceutical treatment. When a cosmetic process or a cosmetic composition are concerned, said adverse effects especially include skin discomfort, as defined above. The increase of the tolerance of an individual to a cosmetic or pharmaceutical treatment, oral or topical, can be illustrated by a better observance of the patient vis-à-vis said cosmetic or topical pharmaceutical treatment.

According to still other aspects, the invention relates to a cosmetic process for the prevention or treatment of cutaneous reactions caused by a topical or oral cosmetic treatment, comprising the topical or oral administration of at least one cosmetic active agent , and the oral administration of at least one comprising at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt, and (iii) vitamin vs.

It is also shown according to the invention that the implementation of the method defined above makes it possible to increase the effectiveness of a topical treatment against imperfections or skin disorders. In particular, it is shown in the examples that the administration of said oral composition increases the effectiveness of a topical treatment, in that the beneficial effects of said topical treatment are maintained over time because of the oral composition, after stopping. said topical treatment.

Unexpectedly, the inventors have shown that the systemic administration of a composition comprising at least at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a salt zinc, and (iii) vitamin C, is able to reduce the undesirable effects, in particular the effects of discomfort, caused by a local treatment, and more specifically by cosmetic treatments and certain pharmaceutical treatments, in particular certain treatments. whether these cosmetic or pharmaceutical treatments are administered topically or orally. Said systemic administration of said soothing agent is also able to reduce the undesirable effects caused by another oral, cosmetic or pharmaceutical systemic treatment.

Also, thanks to the process using the oral composition comprising at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt, and (iii) vitamin C, the duration of the cosmetic or pharmaceutical treatment, topical or oral, against disorders and / or skin discomfort can be reduced, compared to the time required when said cosmetic treatment or pharmaceutical is not accompanied by the oral administration of said soothing agent.

The inventors have also shown that it is advantageous to continue the oral administration of the composition comprising at least at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt, and (iii) vitamin C, after stopping the cosmetic or pharmaceutical treatment. It is shown in particular that, during this additional period of time, said oral cosmetic composition may be used in substitution of the cosmetic (s) or pharmaceutical (s), topical (s) or oral (s) active (s).

The results obtained by the inventors show that the composition for oral administration above can be used successfully to reduce, partially or totally, the residual skin changes resulting from a cosmetic or pharmaceutical treatment, when said composition for oral administration is administered after said cosmetic or pharmaceutical treatment. In other words, said composition for oral administration can be used successfully, in particular after the resolution of a physiological problem of the skin, for example after treatment of the acute and / or eruptive phase of acne.

In other aspects, it may be advantageous to precede the beginning of the topical or oral cosmetic or pharmaceutical treatment with a preliminary period of administration of the oral composition comprising at least at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt, and (iii) vitamin C.

It is therefore shown according to the invention that the oral administration of a composition comprising at least at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a salt zinc, and (iii) vitamin C, is capable of increasing the effectiveness of a cosmetic or pharmaceutical treatment, which encompasses a topical cosmetic or pharmaceutical treatment and a cosmetic or pharmaceutical treatment / dermato oral logic.

It is thus shown in the examples that the administration of said oral composition increases the effectiveness of a topical treatment, in that the beneficial effects of said topical treatment are maintained over time because of the oral composition, after the stop said topical treatment. The present invention also relates to a cosmetic method for increasing the effectiveness of a topical or oral cosmetic treatment against cutaneous imperfections, in particular against cutaneous imperfections of oily or hyperseborrhoeic fatty skin, comprising oral administration. an oral composition comprising at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt, and (iii) vitamin C.

In advantageous embodiments, said oral composition also comprises vitamin B6.

According to other aspects, the present invention relates to the cosmetic use of an oral composition comprising at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a salt zinc, and (iii) vitamin C, for the prevention or treatment of aesthetic defects of the skin.

For the purposes of the invention, the skin imperfections include gloss, heterogeneity and irregularity of the color and / or relief, thickening, opacity, skin texture, shiny appearance, appearance greasy, sticky or messy, pimples and scars that may result, unsightly closed comedones or open, microcysts, nodules, papules and pustules. Aesthetic defects also include residual irregularities of the surface of the skin caused by cosmetic or pharmaceutical treatments, or caused by physiological conditions, for example by a hyperseborrhoeic state or an acne state, which justified the application of said cosmetic treatments or pharmaceuticals. For example, aesthetic defects include residual signs of an acne skin condition. In particular, aesthetic defects include residual skin surface irregularities caused by microcysts, nodules, papules and pustules.

Skin imperfections, especially of oily, acne-prone or hyperseborrheic skin, include defects in the sharpness of the skin, the gloss of oily skin, a cloudy or heterogeneous complexion, the shiny appearance, the greasy, sticky or messy appearance and that the difficult holding of makeups and powders related to this hyper seborrhea, and in particular the aesthetic defects and skin imperfections detailed below. More particularly in the field of skin color, it can be seen that heterogeneity of the complexion showing areas of different colors even plates or spots, buttons, scars and closed or open comedones including black dots; there is also an irregularity of the surface condition in connection with dilated pores, pimples, scars or microcysts or even fine lines compared to the largest acne lesions. The condition of the skin is particularly degraded with thickened skin, opaque in places showing sometimes dull areas sometimes bright and shiny areas or even dander, thus highlighting great disparities in the grain of the skin, especially for the face at a T-shaped area (referred to as the T-zone) encompassing the forehead, nose and chin as opposed to the rest of the face just as these disparities may also appear on the chest and upper back with respect to areas often less affected like arms and legs. Sometimes, these aesthetic defects can even affect the hair including hyperseborrhoeic individuals by loading by contact with sebum produced in the face and thus include weighing, dulling, sticking and affect the color.

According to other aspects, the present invention also relates to an oral composition comprising at least one comprising at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt and (iii) vitamin C for the prevention or treatment of cutaneous reactions to cosmetic or dermatological, oral or topical treatment.

As is apparent from the following, the oral administration of the soothing agent according to the invention can be carried out previously, jointly and / or after the topical or oral application of the cosmetic or dermatological treatment which is sought after. to get rid of undesirable skin reactions that it is likely to induce.

In certain embodiments of the cosmetic use or process of the invention, said topical or oral cosmetic or pharmaceutical application and said oral administration are carried out in less than a part in conjunction with one another.

In certain embodiments of the cosmetic use or process of the invention, said application of a cosmetic or pharmaceutical composition, topically or orally, and said oral administration of the soothing agent are carried out simultaneously, intermittently, or separately in time.

Within the meaning of the invention, said cosmetic or pharmaceutical treatment, topical or oral, and said oral administration of the soothing agent are carried out simultaneously when the implementation of the method comprises at least one period of time during which the cosmetic or pharmaceutical treatment (eg the topical (s) or oral active (s)) and the oral composition of soothing agent are applied / administered simultaneously, ie during the same 24-hour period, for example during the same day, if necessary at different times of the same 24-hour period, the if necessary of the same day. Said period of time during which the cosmetic or pharmaceutical treatment (e.g., the topical active (s)) and the oral composition of soothing agent are applied / administered simultaneously may be of varying duration. It is at least a day.

Said application of a cosmetic or pharmaceutical composition, topically or orally, and said oral administration of the soothing agent are carried out intermittently when the cosmetic or pharmaceutical treatment (eg the active agent (s) topical (s)) and the oral composition of soothing agent are administered alternately over time, that is to say at intervals of more than 24 hours. When the cosmetic or pharmaceutical application and the oral administration of the soothing agent are carried out intermittently, (i) the period of administration of the cosmetic or pharmaceutical composition, between the beginning and the cessation of said cosmetic or pharmaceutical treatment and (ii) the period of oral administration of the soothing agent, between the onset and cessation of said oral treatment, overlap.

Said topical application and said oral administration are carried out separately in time when said cosmetic or pharmaceutical composition and said soothing agent oral composition are administered for periods of time which never overlap.

However, according to preferred embodiments, the cosmetic process of the invention is characterized in that it comprises:

the oral administration, for a first period of time, of said composition comprising at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt, and iii) vitamin C.

the administration, for a first period of time, of a topical or oral cosmetic or pharmaceutical treatment (for example, the topical active agent (s)); and it being understood that at least a portion of said first period of time and at least a portion of said second period of time are simultaneous. The fact that at least some of said first period of time and at least a portion of said second period of time are simultaneous defines a period of joint administration of the two compositions.

The administration of the cosmetic or pharmaceutical composition, or the oral administration of the soothing agent is carried out at least once per period of time. Preferably, the periods of time can be divided into units of time, in particular of equal duration, for example in day or week. In such an embodiment, oral administration or topical administration is performed at least once per unit of time, for example at least once a day.

Thus, according to one embodiment, the method of the invention comprises (i) a first period of time comprising the simultaneous or intermittent administration of the oral composition of soothing agent and of the cosmetic active agent (s) ( s) or pharmaceutical (s), topical (s) or oral (s), said first period of time being followed by (ii) a second period of time comprising oral administration of said active ingredient (s) cosmetic (s), in the absence of the oral composition of soothing agent.

According to another embodiment, the method of the invention comprises (i) a first period of time comprising the administration of the oral composition of soothing agent in the absence of the cosmetic active (s) or pharmaceutical (s), topical (s) or oral (ux), said first period of time being followed (ii) a second period of time comprising the joint administration of the cosmetic (s) or pharmaceutical (s) active (s) (s) and the oral composition of soothing agent.

In some embodiments of the method, said oral cosmetic composition of soothing agent is administered during only a part or during the entire duration of administration of said (s) cosmetic or pharmaceutical active (s), topically or orally.

In preferred embodiments of the method, the administration of said oral soothing agent is continued after stopping the administration of said (said) cosmetic or pharmaceutical active ingredient (s).

Advantageously, the cosmetic or pharmaceutical active agent (s) is (are) administered topically or orally, continuously, that is to say daily, or intermittently, for a period ranging from 5 days to 120 days, which ranges from 10 days to 60 days, and from 20 days to 45 days, for example 60 days. Advantageously, said soothing agent is administered orally, continuously, that is to say daily, or intermittently, for a period ranging from 5 days to 200 days, which encompasses from 10 days to 150 days, and from 20 days to 100 days, for example 90 days.

In preferred embodiments of the cosmetic process of the invention, the administration of said soothing agent orally is initiated simultaneously with the application of the cosmetic or pharmaceutical composition and is extended beyond the latter. For example, (i) administration of the cosmetic (s) or pharmaceutical (s) active (s) and (ii) administration of the oral soothing agent are initiated simultaneously, and carried out jointly, so simultaneous or intermittent, for a first period of at least 5 days and preferably at least 30 days, then oral administration of said composition is continued for a second period subsequent to said first period, said second period having a duration at least 5 days and preferably at least 10 days,

As already mentioned, the invention also relates to an oral composition comprising at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt, and (iii) vitamin C, for the prevention or treatment of cutaneous reactions to a cosmetic or dermatological treatment, topical or oral.

The invention also relates to the use of at least at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt, and (iii) vitamin C for the preparation of a pharmaceutical composition, for the prevention or treatment of cutaneous reactions caused by an oral or topical cosmetic treatment, or by an oral or topical pharmaceutical / dermatologic treatment, in particular a topical dermatological treatment.

Topical pharmaceutical or dermatological treatments include the treatment of hyperseborrhoeic skin, skin imperfections, signs of skin aging, skin pigment disorders, acne, as well as moderate to severe dandruff conditions.

The various aspects of the present invention are also defined below in connection with the description of (i) the soothing oral administration agent composition used and (ii) cosmetic or pharmaceutical / dermatological treatments, by or topical or oral whose adverse effects are reduced, or whose effectiveness is increased, when said oral composition of soothing agent defined in the present description is administered.

In advantageous embodiments, said oral composition also comprises vitamin B6.

Composition for oral administration (soothing agent)

The compounds contained in the composition for oral administration, also called soothing agent in the present description, are advantageously used in doses or quantities for which an optimal effect is expected.

Thus, in certain embodiments, the method is characterized in that said oral composition is suitable for the daily administration of a combination of compounds comprising (i) from 0.1 to 5000 mg of a polyphenol or a mixture of polyphenols, (ii) from 0.1 to 1000 mg of zinc, preferably in the form of a zinc salt, and (iii) from 1 to 3000 mg of vitamin C.

polyphenols

In particular embodiments, said oral cosmetic composition is suitable for the daily administration of 10 to 500 mg, advantageously 30 to 200 mg, of a polyphenol or a mixture of polyphenols.

The polyphenol compounds include a large family of compounds widely distributed in the plant kingdom. They are found in particular in plants, from roots to fruits. Among the classes of polyphenols, there may be mentioned flavonoids, proantocyanidines, lignans, lignins, stilbenes, phenolic acids, coumarins. Thus, the polyphenol compound used in the context of the present invention may be in an isolated form or in all the forms mentioned below.

According to the invention, the term "polyphenols" is more particularly understood to mean compounds of the flavonoid type, that is flavones, flavonols, isoflavones, anthocyanins, flavanols, proanthocyanidines, flavanones, chalcones (eg phloridzin), stilbenes and the chlorogenic acid family.

In the context of the present invention, the polyphenol compound may in particular derive from plant extracts chosen from extracts of green tea, grapes such as Vitis Vinifera, pine and in particular pine bark, apple, blueberry, hops, guava, cocoa, wood such as chestnut, oak, horse chestnut, hazelnut.

The term "polyphenol compound" in the context of the present invention therefore also extends to the plant extract itself, rich in these polyphenol compounds. The avononoids are the main group of polyphenols.

The catechol polyphenols constitute, for their part, a subgroup of the avonoid, which also include the flavanones, the flavones and anthocyanins, and the avonols.

Particularly suitable are the avonols, anthocyanins, flavanols, proanthocyanidines and flavanones and stilbenes.

Flavanols are especially chosen from catechins and gallocatechins.

Procyanidins are polymers of avonols present as low-level polymer blends. They can be associated with catechins in plant extracts.

The polyphenols or polyphenol mixtures include catechin, epicatechin, repigallocatechin-3-O-gallate, epigallocatechin, epicatechin-3-gallate, procyanidins, proanthocyanidins, and mixtures thereof.

It is particularly advantageous to use catechin monomers optionally mixed with procyanidin oligomers (OPC).

These inputs of polyphenols can be made from isolated compounds and / or from plant extracts and mixtures thereof.

It will be possible according to the invention to use plant extracts that can provide all of these polyphenols.

More particularly, catechins are very abundant in tea (Camellia

Simensis), coffee and grapes (Vitis Vinifera) and other fruits (apple, pear, pine cone) (Pinus Maritima). The beverages (wine, beer, tea) and chocolate (Theobroma Cacao) are sources that can constitute inputs of catechins according to the invention.

These polyphenols may be used alone or used in the form of mixtures of several polyphenols.

By way of example, mention may be made of an extract of grape seed at 83% OPC, a red wine extract with 30% total polyphenols and / or a green tea extract with 30% catechins.

Procyanidin oligomers (OPC) can be provided by a grape seed extract, which is titrated according to its OPC titre. By way of example, for an 83% OPC grape seed extract, above, it can be used at a dose of about 200 mg / day, ie about 170 mg / day OPC.

The polyphenols can be selected from one of the above categories, and mixtures can also be made. The composition for oral administration may comprise from 0.01 to 30% by weight of at least one polyphenol, relative to the total weight of said composition. In preferred embodiments, said composition for oral administration comprises from 0.1% to 60% by weight, for example from 5% to 40% by weight, based on the total weight of said composition.

It is specified that the polyphenols of the chlorogenic acid family are found mainly in coffee extracts, in extracts of artichoke, or in extracts of chicory. The family of chlorogenic acids includes compounds formed by a chlorogenic acid, or a plurality of chlorogenic acids, conjugated with quinic acid. The chlorogenic acids include chlorogenic acid per se (iran-5-O-caffeylquinic acid) as well as ferulylquinic acid, p-coumarylquinic acid, sinapylquinic acid, dicafeylquinic acid, caffeyl-2,6-dicarboxylic acid, diferulylquinic acid, di-p-coumarylquinic acid and dimethoxy cinnamylquinquinic acid.

Most preferably, a mixture of polyphenols in the form of a grape seed extract is used. Zinc

In particular embodiments, said oral cosmetic composition adapted to the daily administration of 1 to 100 mg of zinc, advantageously from 5 to 30 mg of zinc, preferably in the form of a salt or a zinc oxide, and most preferably zinc gluconate.

In the present description, an amount of salt or zinc oxide refers to the amount of elemental zinc contained in said salt or said oxide. As an illustration, 24.5 mg of zinc gluconate is expressed as 3.52 mg of zinc in the form of gluconate.

Zinc is preferentially in the form of a salt or an oxide.

The zinc salts are chosen in particular from acid salts and halides.

The acid salts include sulphate, borate, and carboxylic acid salts. The carboxylic acid salts include acetate, carbonate salts.

Halides of chloride, iodide and fluoride.

Preferentially, the zinc salts are chosen from gluconate, acetate, sulphate, chloride, citrate, lactate or carbonate. In some embodiments, the composition for oral administration comprises from 0.001% to 10% by weight, and preferably from 0.01% to 5% by weight of zinc, where appropriate in the form of a salt or a zinc oxide, based on the total weight of said composition.

In the present description, an amount of salt or magnesium oxide refers to the amount of elemental magnesium contained in said salt or said oxide. By way of illustration, a quantity of 266.67 mg of magnesium sulfate is expressed as 53.8 mg of magnesium in the form of sulfate.

Magnesium salts include sulfate, chloride and phosphate.

Most preferably, the magnesium salt is magnesium sulfate.

In some embodiments, the composition for oral administration comprises from 0.1% to 70% by weight, and preferably from 1% to 40% by weight of magnesium, where appropriate in the form of a salt, by weight. relative to the total weight of the composition.

Vitamin C

In certain particular embodiments, the oral cosmetic composition suitable for daily administration of 5 to 2000 mg, and advantageously of 10 to 300 mg of vitamin C, preferentially in the synthetic form or provided by plant extracts (for example acerola, orange, acai or pomegranate).

In some embodiments, the composition for oral administration comprises from 0.1% to 400% by weight, and preferably from 1% to 20% by weight of vitamin C, based on the total pea of said composition.

Other active ingredients and excipients of the composition for oral administration (soothing agent) Magnesium

In particular embodiments, the oral cosmetic composition suitable for the daily administration of 1 to 3000 mg of magnesium, better still from 5 to 2000 mg of magnesium, advantageously from 10 to 300 mg of magnesium, preferably in the form of a salt or magnesium oxide.

Vitamin B6

In certain particular embodiments, the oral cosmetic composition suitable for the daily administration of 0.01 mg to 500 mg of vitamin B6, better still of 0.1 mg to 100 mg, and advantageously of 1 to 20 mg, of vitamin B6. .

In some embodiments, the composition for oral administration comprises from 0.001% to 10% by weight, and preferably from 0.005% to 5% by weight vitamin B6, based on the total pea of said composition.

Other active ingredients and excipients

The composition for oral administration, or soothing agent, may optionally contain suitable formulation excipients such as dye, sweetener, bulking agent, binder, preservative, etc. According to a preferred embodiment, the active ingredients can be incorporated in food matrices in order to produce functional foods such as food bars, fortified foods such as oils, margarines, compacted powders, fibers or even under the emulsion form in drinks.

The composition for oral administration may further contain compounds such as antioxidants, additional vitamins, minerals authorized in Europe in food supplements as described in the EC Directive 2002/46. Additional active ingredients include dietary antioxidants, nutrients with anti-free radical properties and endogenous antioxidant enzymes: vitamins A, E, carotenoids such as lycopene, xantophyls, isoflavones, certain minerals such as copper, selenium, lipoic acid, co-enzyme QIO, superoxide dismutase (SOD) or taurine. Among the anti-aging active ingredients, unsaponifiable fractions extracted from plant-derived lipids, aloe vera, native marine collagen or hydrolysis, vegetable or marine oils rich in omega-3 fatty acids, omega-6, including gamma-linolenic acid).

Among the nutritional assets photoprotection, we can mention: antioxidants and antiradicals: vitamins A, E, carotenoids, xantophyls, certain minerals such as copper, selenium, co-enzyme QIO, superoxide dismultase (SOD), probiotics. Nutritional ingredients with hydrating or immunomodulatory properties may also be mentioned: probiotics, polypodium leucotomos extract, vegetable or marine oils rich in [Omega] -3 fatty acids, [Omega] -6, including acid gamma-linolenic.

Additional active ingredients include: mate, horse chestnut, cola, caffeine, theobromine, synephrine, bromelain, ephedra, citrus aurantium, citrus sinensis, calcium, hoodia, garcinia, chitosan, plant fibers (cactus, apples, pineapple, ...), fennel, blackcurrant, queen of the meadows, black radish.

In certain advantageous embodiments, said oral composition comprises an additional active agent or a combination of additional active agents chosen from:

one or more vitamins other than vitamin C and vitamin B6, which includes vitamins B3, B5, B6, B8, E, D, K or PP,

- one or more minerals other than zinc and magnesium,

one or more probiotic or prebiotic agents,

one or more antioxidants such as selenium,

one or more carotenoids such as lycopene or lacto-lycopene, and

one or more substances chosen from curcuminoids, sugars, amino acids, sulfur amino acids, polyunsaturated fatty acids, glucosamine, phytosterols, essential oils, ubiquinones, resveratrol, coffee extracts and chocolate, taurine, amino acids, glutathione precursors, and polyunsaturated fatty acids such as omega-3 or omega-6 polyunsaturated fatty acids.

Said composition for oral administration may especially be in a form chosen from soft capsules, wrapped capsules, gels, dry or liquid emulsions, tablets, powders for dilution or drinkable ampoules.

In other embodiments, said composition for oral administration is in a form selected from a food supplement and functional food.

The unmanageable support may be of various nature depending on the type of composition considered.

For example, they may be food supplements, the formulation of which may be carried out by the usual methods for producing, in particular, dragees, capsules, gels, emulsions, tablets, capsules and hydrogels allowing controlled release.

In particular, the constituents of the composition for oral administration can be incorporated into all forms of food supplements or fortified foods, for example food bars or powders, compacted or not. The powders can be diluted in water, soda, dairy products or soy derivatives, or incorporated into food bars.

Food or pharmaceutical carriers may be those selected from milk, yoghurt, cheese, fermented milks, fermented milk products, ice creams, fermented cereal based products, milk-based powders , formulas for children and infants, confectionery-type foods, chocolate, cereals, especially pet food, tablets, capsules or soft capsules, oral supplements in dry form and oral supplements in liquid form.

The said composition for oral administration may also comprise fatty and / or aqueous components, humectants, thickeners, preservatives, texturing agents, flavoring agents and / or coating agents, antioxidants, preservatives and colorants which are customary in the food industry. The formulating agents and excipients for oral composition, and especially for food supplements, are known in the art and are not the subject of a detailed description here.

The uses, as well as the cosmetic or pharmaceutical methods disclosed in the present description, which are defined in more detail below, in connection with (i) the oral or topical treatments that may be implemented and (ii) the indications cosmetics or the pharmaceutical / dermatological indications provided for the said treatments Topical treatments and cosmetic or pharmaceutical / dermatological indications

As has already been specified in the present description, the treatments whose undesirable effects are reduced, or whose efficiency is increased, because of the use of the composition comprising at least (i) a polyphenol or a mixture of polyphenols (ii) zinc, preferably in the form of a zinc salt, and (iii) vitamin C, include cosmetic treatments and pharmaceutical / dermatological treatments.

In advantageous embodiments, said oral composition also comprises vitamin B6.

1. Cosmetic treatments

Among the cosmetic treatments, are primarily concerned all types of purely aesthetic treatments of the skin or scalp.

Cosmetic treatments include those intended to prevent or treat skin imperfections, signs of skin aging, skin wrinkles and wrinkles, pigmentary disorders, as well as moderate to severe dandruff conditions of the scalp.

Pigmentary disorders include hyperpigmentary disorders such as chloasma.

Aesthetic reasons are the main reason for consulting patients affected by a skin pigment disorder, including skin hyperpigmentation. In In general, skin pigment disorders, including hyperpigmentations of the skin, are asymptomatic and have no medical consequences.

Cosmetic treatments generally include physical or chemical peeling or peeling methods as well as XXXXX patches.

2. Pharmaceutical or dermatological treatments

The general conditions concerned by pharmaceutical or dermatological treatments may partially overlap with those of which only the signs are prevented or treated cosmetically.

Pharmaceutical or dermatological treatments also include the prevention or treatment of acne.

The pharmaceutical or dermatological treatments also include in particular the treatment of cutaneous disorders such as pigment disorders. 3. Actiffs and excipient (s for topical or oral application

In general, the active agent (s) for topical application which are used in the process of the invention are included in a topical cosmetic composition. In general, said topical cosmetic composition comprises said cosmetic active (s) against disorders, imperfections or skin discomforts in a cosmetically acceptable carrier.

Acne

In some embodiments, said cosmetic actives for topical application include cosmetic anti-acne actives. The anti-acne cosmetic active ingredients include benzoyl peroxide, salicylic acid, a quaternary ammonium lipophilic salicylate, retinoic derivatives and certain antibacterial agents.

For example, for the treatment of acne, it is possible to use retinoids, and especially retinoic acid, peroxides such as benzoyl peroxide and hydroxy acids.

Retinoids are also used for treatment, photoaging, stretch marks and psoriasis. Pigmentary disorders

Most often, the treatments recommended for hyperpigmentation disorders are depigmenting topical products, chemical peels, cryosurgery and lasers.

To treat dyschromia, depigmenting agents such as hydroquinone are used.

Ascorbic acid is used to remove stains and scars, including scars from acne. Skin aging

Hydroxy acids are used again for the treatment of aging, cutaneous, as well as retinoids.

other assets

Among the other active agents, niacinamide, isopropyl Lauroyl sarcosinate, polyacryloyldimethylammonium taurate, salicylic acid, zinc PCA, linoleic acid, pentaerythrityl tetra-di-tert-butylhydroxyhydrocinnamate, capryloyl glycine, caprylyl salicylic acid, caprylyl glycol and capryoyl salicylic acid. 4. Additional characteristics of assets that may be used

As regards the quaternary ammonium salicylates, the person skilled in the art can refer in particular to the European patent application No. EP 317846 in the name of L'Oréal.

Retinoic acid and its derivatives include those described in FR-A-2 570 377, EP-A-199 636, EP-A-325 540, EP-A-402 072. Retinoic derivatives include tretinoin, adapalene and tazorotene.

Antibacterial agents include clindamycin, oxytetracycline, minocycline and erythromycin.

The anti-acne cosmetic active ingredients can be used in combination in a "cosmetic active" which is applied topically during the implementation of the cosmetic process according to the invention.

Preferably, the anti-acne active agent is benzoyl peroxide. In some embodiments, said cosmetic active agent is chosen from comedolytic, keratolytic or verrulytic active agents.

According to other aspects, said cosmetic active agent is chosen from anti-acne cosmetic active ingredients, anti-seborrhoeic cosmetic active ingredients and anti-bacterial and / or anti-fungal cosmetic active ingredients.

Cosmetic active ingredients against skin disorders, discomfort and imperfections also include niacinamide, olocolinamide, beta-lipohydroxy acid (LHA), which can be used alone or in combination.

Topical cosmetic active ingredients also include anti-seborrhoeic agents such as certain sulfur amino acids, 13-cis retinoic acid, cyproterone acetate.

Topical cosmetic active ingredients also include desquamating agents, which may also be peeling agents.

Among the agents specifically for peeling, mention may be made of abrasive / exfoliating particles of mineral, organic, natural or synthetic sources. Mention may be made more particularly of particles of pumice stone, silica, polyethylene balls, nylon and powders of fruit cores. The peeling agents include, in particular, 8-hexadecene-1,16-dicarboxylic acid (dioic acid), citric acid, lactic acid, glycolic acid, tartaric acid, malic acid, mandelic acid, ascorbic acid and its derivatives, nicotinic acid and nicotinamide, desquamating agents such as urea, beta-hydroxy acids, certain jasmonic acid derivatives, chelating agents such as EDTA, dermabrasion.

Among these desquamating agents, the following are likely to cause irritation of the skin and / or the scalp: saturated monocarboxylic acids (acetic acid) and unsaturated, saturated and unsaturated dicarboxylic acids, saturated and unsaturated tricarboxylic acids; α-hydroxy acids and β-hydroxy acids of monocarboxylic acids; the α-hydroxy acids and β-hydroxy acids of the dicarboxylic acids; α-hydroxy acids and β-hydroxy acids, tricarboxylic acids, ketoacids, α-ketoacids, β-keto acids of polycarboxylic acids, polyhydroxy monocarboxylic acids, polyhydroxybicarboxylic acids and polyhydroxy tricarboxylic acids. Particularly among α-hydroxy acids or their esters include: gly colonic, dioecious acids such as octadecene dioic acid or Arlatone dioc DCA sold by Uniqema, citric, lactic, tartaric, malic or mandelic, their esters such as tartrate of dialkyl (C12 / C13) or Cosmacol ETI, the citrate of branched C12-13 tri-alcohols or Cosmacol ECI sold by the company SASOL.

Among the β-hydroxy acids that may be mentioned: salicylic acid and its derivatives (including n-octanoyl-5-salicylic acid).

Α-Ketoacids include ascorbic acid and its derivatives.

Other desquamating agents that may be mentioned include: pyruvic, gluconic, glucuronic, ketogulonic, glycolic, oxalic, malonic, succinic, acetic, gentisic, cinnamic and azelaic acids; phenol; resorcinol; urea and its derivatives, hydroxyethyl urea or hydrovance® from NATIONAL STARCH; oligofucoses; jasmonic acid and its derivatives; ascorbic acid and its derivatives, trichloroacetic acid; Saphora japonica extract and Resveratrol.

Among the desquamating agents, those capable of acting on the enzymes involved in the desquamation or degradation of corneodesmosomes may also be capable of causing irritation of the skin and / or scalp or a discomfort skin reaction.

Among these, there may be mentioned the chelating agents of mineral salts such as EDTA; N-acyl-N, N ', N'-ethylene diaminetriacetic acid; aminosulphonyl compounds and in particular (N-2-hydroxyethylpiperazine-N-2-ethane) sulfonic acid (HEPES); 2-oxothiazolidine-4-carboxylic acid derivatives (procysteine); glycine-type alpha amino acid derivatives (as described in EP 0 852 949, as well as sodium methyl glycine diacetate marketed by BASF under the trade name TRILON M®); honey ; sugar derivatives such as O-octanoyl-6-D-maltose, O-linoleyl-6-D-glucose and N-acetyl glucosamine.

The compositions comprising a cosmetic active agent against disorders, discomfort and cutaneous imperfections, are essentially characterized by the fact that they are topical compositions containing, in combination, in a physiologically acceptable support, said cosmetic active agent, for example benzoyl peroxide. In the case of dynamic phototherapie (PDT) processes, the photoactivatable agents applied topically and intended to be activated photodynamically are chosen in particular from the family of aminolevulinic acids such as 5-aminolevulinic acid marketed for example under the name Levulan. ®; Kerastick® or 5-aminolevulinic methyl such as Metvix® or any photoactivatable functional equivalent.

5. Formulations for topical applications

The compositions may be in the form of solutions, emulsions, suspensions, gels or dispersions.

Advantageously, when the cosmetic active ingredient is benzoyl peroxide, said composition for topical application comprises benzoyl peroxide in concentrations of between 0, 1 and 20% by weight and preferably between 1 and 10% by weight, by weight. relative to the total weight of the composition.

In the case of a composition according to the invention for oral administration, the use of an ingestible support is preferred.

These compositions may contain physiologically acceptable vehicles and adjuvants, which are well known in the state of the art. For example, solutions, micro-suspensions or vesicular emulsions can be prepared using one or more physiologically acceptable organic solvent (s) selected in addition to water. among solvents such as acetone, ethanol, isopropyl alcohol, glycol ethers such as the products sold under the name of "DOWANOL", polyglycols, polyethylene glycols, C1-C4 alkyl esters short-chain acid, preferably ethyl or isopropyl lactates, triglycerides of fatty acids such as the products sold under the name "MIGLYOL" and isopropyl myristate.

The compositions in accordance with the invention may also contain thickening and gelling agents chosen, for example, from cellulose and its derivatives, guar gum, heterobiopolysaccharides, crosslinked polyacrylic acid, methacrylic acid / methyl methacrylate copolymer, poly-beta-alanine, colloidal silica, softeners, superfatting agents, emollients, wetting agents, surfactants, pH regulators, penetrating agents, preservatives, agents defoamers, sunscreens, oils, waxes, perfumes, dyes and / or pigments whose function is to color the skin or the composition itself and any other ingredient usually used in compositions intended for topical application.

Of course, excipients and ingredients that could undesirably react with the benzoyl peroxide used in accordance with the invention should be excluded.

The compositions in accordance with the invention may also contain, in combination, anti-acne agents such as retinoic derivatives, antibacterial agents, anti-inflammatory agents, non-hormonal steroidal agents, in particular pregnenolone, and / or keratolytic or comedolytic agents.

The galenic forms mainly conditioned for the topical route are in the form of creams, milks, gels, dispersions or microemulsions, more or less thickened compositions, soaked swabs, ointments, sticks or in the form of soap bars.

In the following description and examples, unless otherwise indicated, percentages are percentages by weight and ranges of values in the form "between ... and ..." include the specified lower and upper bounds.

The ingredients are mixed, before they are shaped, in the order and under conditions easily determined by those skilled in the art.

The content and the nature of the ingredients used in the compositions of the invention are adjusted by those skilled in the art so as not to substantially affect the properties required for the compositions of the invention.

The following examples are presented by way of illustration and not limitation of the field of the invention. EXAMPLES

Example 1: Composition Example for Oral Administration - Tablets Form

The qualitative and quantitative composition of ingredients of an exemplary composition for oral administration, in tablet form, is described in Table 1 below.

Table 1

Nutritional Ingredient / Additive Composition

(Mg / tablet)

Zinc Carbonate 25

Vitamin C 22

Grape Seed Extract (83-90% OPC Titrated) 67

Magnesium chloride 250

Vitamin B6 1

Excipients for the nucleus

Micro crystalline cellulose 110

Silicon dioxide 4

Silicon dioxide 11

Magnesium stearate 5

Film lamination agent

Gum-lake 5

Titanium dioxide 0.4

Talc 5

Carnauba wax 0.3 Example 2: Composition Example for Oral Administration - Tablets Form

The qualitative and quantitative composition of ingredients of another example of composition for oral administration, in tablet form, is described in Table 2 below.

Table 2

Nutritional Ingredient / Additive Composition

(Mg / tablet)

Zinc Carbonate 25

Vitamin C 22

Grape Seed Extract (83-90% OPC Titrated) 67

Excipients for the nucleus

Micro crystalline cellulose 250

Silicon dioxide 5

Silicon dioxide 13

Magnesium stearate 5

Film lamination agent

Gum-lake 5

Titanium dioxide 0.4

Talc 5

Carnauba wax 0.3

Example 3: Composition Example for Oral Administration - Form Capsules (Fish Gelatin)

The qualitative and quantitative composition of ingredients of an exemplary composition for oral administration, in capsule form, is described in Table 3 below.

Table 3

Nutritional Ingredient Composition

(Mg / capsule)

Zinc sulphate 40

Vitamin C 30

Pine bark extract (65-70% OPC titrated) 100

Magnesium gluconate 400

Vitamin B6 2

Additive

Corn starch 200

Magnesium Stearate 7

Silicon dioxide 21

EXAMPLE 4 Example of composition for oral administration - form sachet to be diluted (strawberry flavor)

The qualitative and quantitative composition of ingredients of an exemplary composition for oral administration, in the form of a bag to be diluted, is described in Table 4 below.

Table 4

Nutritional Ingredient Composition

(Mg / capsule)

Zinc Gluconate 40

Vitamin C 30

Cocoa extract (40% flavanols titrated) 200

Magnesium sulphate 300

Vitamin B6 2

Additive

Citric acid anhydrous 1000

Strawberry aroma 50

Maltodextrin 30

Acacia gum 10

Sucralose 30

Colloidal silicon dioxide 4

Example 5: Composition Example for Oral Administration - Tablets Form

The qualitative and quantitative composition of ingredients of another example of composition for oral administration, in tablet form, is described in Table 5 below.

Table 5

Nutritional Ingredient Composition

(Mg / capsule)

Zinc Gluconate 30

Vitamin C 25

Apple extract (titrated with 5% phloridzine) 300

Excipient for the core

Micro crystalline cellulose 150

Silicon dioxide 5

Colloidal silicon dioxide 3

Silicon dioxide 8

Magnesium stearate 5

Film lamination agent

Gum-lake 5

Titanium dioxide 0.4

Talc 5

Carnauba wax 0.3

Example 6: Example of Composition for Oral Administration - Form Capsules (Fish Gelatin)

The qualitative and quantitative composition of ingredients of another example of a composition for oral administration, in capsule form, is described in Table 6 below.

Table 6

Nutritional Ingredient Composition

(Mg / capsule)

Zinc Gluconate 30

Vitamin C 25

Orange extract titrated to 90% hesperidin 150

Magnesium gluconate 100

Additive

Corn starch 200

Magnesium Stearate 7

Silicon dioxide 21

EXAMPLE 7 Example of composition for oral administration - form sachet to be diluted

The qualitative and quantitative composition of ingredients of another example of composition for oral administration, in the form of a bag for dilution, is described in Table 7 below.

Table 7

EXAMPLE 8 Clinical Results Obtained with the Cosmetic Procedure in the Case of a Topical Treatment with Benzoyl Peroxide (BPO) in Acneic Substances

This dermatologically controlled study was conducted in women (n = 166) aged 18 to 40 years with mild to moderate acne. In a first phase, these women were divided into two treatment groups:

- group 1 treated with benzoyl peroxide 5% (w / w) for 60 days at one application per day (control group)

- Group 2 treated with benzoyl peroxide 5% (w / w) for 60 days at a rate of one application per day associated with the daily intake of the oral supplement as described in Example 1. The control of the tolerance to the treatments was carried out after 30 and 60 days by means of questionnaires given to the dermatologists and the subjects participating in the study.

The results of the overall clinical assessment performed by dermatologists after 60 days are shown in Table 8 below. The figures in Table 8 correspond to% of agreement response more completely agree.

Table 8

* (S): Statistically significant The results of the global clinical assessment performed by users after 60 days are shown in Table 9 below. The figures in Table 3 correspond to the% of agreement response more completely agree.

* (S): Statistically significant

The results of Tables 8 and 9 show, after 60 days of treatment, the superiority of BPO treatment + oral composition versus BPO alone in terms of eliminating / reducing acne lesions, obtaining a healthier and sharper skin. , attenuation of the shiny appearance of the oily skin, purifying and matifying action, unification of the complexion.

In addition, the efficacy results show that, after two months of treatment, the combination of the oral supplement as described in Example 1 and 5% benzoyl peroxide makes it possible to increase the rate of subjects statistically significantly. presenting a "Net improvement" of acne lesions compared to benzoyl peroxide 5% alone.

Group 1: out of 53 subjects, 21 subjects show a net improvement (40%) Group 2: out of 113 subjects, 71 subjects show a net improvement (63%)

Tables 10 (evaluations by dermatologists) and 11 (self-evaluations of subjects) summarize the tolerance results obtained in groups 1 and 2. Quite unexpectedly, a statistically significant difference was found as early as 30 treatment days in favor of group 2. In other words, the tolerance to treatment in group 2 is better than that of group 1 highlighting the interest of the oral composition as described in example 1 to improve tolerance to benzoyl peroxide.

The results of the dermatologic evaluation of treatment tolerance in groups 1 and 2 after 60 days of treatment are shown in Table 10 below. The results are expressed in% of subjects.

Table 10

DERMATOLOGISTS

GROUP 1 GROUP 2

BPO 5% (1 x / day) BPO 5% (1 x / day) + food composition (2 cps / day)

J30 J60 J30 J60

Excellent 15% 17% 26% 47%

Good 51% 58% 57% 49%

Average 34% 23% 18% 4%

Bad 0% 2% 0% 0%

J60 vs J30 MS P <C ⁾ .01

Gl vs G2 Statistically significant difference as of J30

in favor of G2 (p = 0.0167, p = 0) The results of the subjects' assessment of treatment tolerance in groups 1 and 2 after 60 days of treatment are shown in Table 1 1 below. The results are expressed in% of subjects.

Table 11

In summary, the oral composition described in Example 1 not only improves benzoyl peroxide tolerance, but also potentiates its effectiveness.

After 60 days of treatment with (i) the topical composition and (ii) the oral composition, the topical drug treatment is stopped, while the oral composition is continued for an additional 30 days (group 3) . The total duration of the treatment is therefore 90 days. Topics treated only by the BPO continued to apply. The results of the overall clinical assessment performed by users at the end of 90 days of treatment compared to day 60 are shown in Table 12 below. The figures in Table 12 correspond to% agreement response more completely agree.

Table 12

* (S): Statistically significant

The results of the overall clinical assessment performed by dermatologists after 90 days of treatment compared to day 60 are shown in Table 13 below. The figures in Table 13 correspond to% of agreement response more completely agree.

Table 13

* (S): Statistically significant

The results of the dermatologic evaluation of treatment tolerance in groups 1 and 3 after 90 days of treatment are shown in Table 14 below. The results are expressed in% of subjects.

Table 14

DERMATOLOGISTS

GROUP 1 GROUP 3

BPO 5% 1 x / day (between J60 and food composition 2cps / day

J90) (between J60 and J90)

J60 J90 J60 J90

Excellent 17% 19% 47% 69%

Good 58% 57% 49% 26%

Average 23% 25% 4% 5%

Bad 2% 0% 0% 0%

Gl vs G3 Statistically significant difference between J60 and. Γ90 in favor of

G3 (p = 0)

The results of the subjects' assessment of treatment tolerance in groups 1 and 3 after 90 days of treatment are shown in Table 15 below. The results are expressed in% of subjects.

Table 15

The food composition therefore advantageously replaces the topical treatment after a 60-day etching phase combining the oral composition and the topical medicinal treatment, in other words, the oral composition alone justifies an efficacy superior to that of BPO on items such as reducing / eliminating acne lesions, obtaining a clearer and healthier skin, reducing the shiny appearance of oily skin, homogeneity of complexion, purifying and mattifying action. This superiority is also accompanied by a better tolerance in group 3 compared to group 1.

The food composition therefore advantageously replaces the topical medicinal treatment after a 60-day etching phase combining the oral composition and the topical medicinal treatment.

Claims

1. Cosmetic use of an oral composition comprising at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt, and (iii) vitamin C, as a soothing agent.

2. Use according to claim 1, to improve the tolerance to skin discomfort caused by a cosmetic or dermatological treatment topical or oral.

3. Use according to one of claims 1 and 2, characterized in that the oral composition is suitable for the daily administration of a combination of compounds comprising (i) from 0.1 to 5000 mg of a polyphenol or a mixture of polyphenols, (ii) from 0.1 to 1000 mg of zinc, preferably in the form of a zinc salt, and (iii) from 1 to 3000 mg of vitamin C.

4. Use according to one of claims 1 to 3, characterized in that said oral composition also comprises magnesium, preferably in the form of a magnesium salt.

5. Use according to one of claims 1 to 4, characterized in that said oral composition also comprises vitamin B6

6. Use according to one of claims 1 to 5, characterized in that said oral composition is suitable for the daily administration of 10 to 500 mg, preferably 30 to 200 mg, a polyphenol or a mixture of polyphenols.

7. Use according to one of claims 1 to 6, characterized in that the polyphenol (s) are chosen from flavonoids.

8. Use according to one of claims 1 to 7, characterized in that said oral cosmetic composition is suitable for the daily administration of 1 to

100 mg of zinc, preferably 5 to 30 mg of zinc, preferably in the form of a zinc salt, and most preferably zinc gluconate.

9. Use according to one of claims 1 to 8, characterized in that said oral cosmetic composition is suitable for the daily administration of 5 to 2000 mg, and preferably 10 to 300 mg of vitamin C.

10. Use according to one of claims 1 to 9, characterized in that said oral cosmetic composition is suitable for the daily administration of 1 to 3000 mg of magnesium, better still from 5 to 2000 mg of magnesium, advantageously from 10 to 300 mg of magnesium, preferentially in the form of a magnesium salt, and most preferably magnesium sulphate.

11. Use according to one of claims 1 to 10, characterized in that said oral cosmetic composition is suitable for the daily administration of 0.01 mg to 500 mg of vitamin B6, better still from 0.1 mg to 100 mg, and advantageously from 1 to 20 mg of vitamin B6.

A cosmetic process for increasing tolerance to a topical or oral cosmetic or dermatological treatment comprising orally administering an oral composition comprising at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt, and (iii) vitamin C.

13. Cosmetic process for increasing the effectiveness of a topical or oral cosmetic treatment against cutaneous imperfections, in particular against skin imperfections of oily acne or hyperseborrhoeic skin, comprising the oral administration of an oral composition comprising at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt, and (iii) vitamin C.

14. Cosmetic process according to one of claims 12 and 13, characterized in that said oral composition is that defined in any one of claims 1 to 11.

15. Method according to one of claims 12 to 14, characterized in that the topical or oral application of at least one cosmetic or pharmaceutical active agent capable of inducing a cutaneous discomfort reaction, and the administration by oral route of said composition, are carried out in part less

16. Cosmetic process according to one of claims 12 to 15, characterized in that said topical or oral cosmetic or dermatological treatment and the administration of said oral composition are carried out simultaneously, intermittently, or separately.

17. Cosmetic process according to one of claims 12 to 16, characterized in that it is intended to increase the tolerance to a topical cosmetic treatment with at least one cosmetic active and in that it comprises: the administration, for a first period of time, of said cosmetic or pharmaceutical treatment, and

the oral administration, for a second period of time, of said oral cosmetic composition,

it being understood that at least a portion of said first period of time and at least a portion of said second period of time are simultaneous.

18. Cosmetic use of an oral composition comprising at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt, and (iii) vitamin C, for the prevention or treatment of aesthetic defects of the skin, such as gloss, heterogeneity and irregularity of color and / or relief, thickening, opacity, skin texture, appearance shine, greasy, sticky or messy appearance as well as the pimples and scars that may result, unsightly closed comedones or open, residual irregularities of the skin surface caused by microcysts, nodules, papules and pustules.

19. An oral composition comprising at least (i) a polyphenol or a mixture of polyphenols, (ii) zinc, preferably in the form of a zinc salt, and (iii) vitamin C, for the prevention or control of treatment of cutaneous reactions to a cosmetic or dermatological treatment, topical or oral.

20. An oral composition according to claim 19, characterized in that said cosmetic or dermatological treatment is intended for the prevention of a condition selected from skin disorders, skin imperfections, signs of skin aging, pigment disorders, and moderate to severe dandruff conditions

21. Oral composition according to one of claims 19 and 20, characterized in that the skin disorders are selected from among those associated with hyperseborrhoeic skin, acne skin, moderate to severe dandruff, signs of skin aging. or with pigmentary disorders.

22. Oral composition according to one of claims 19 to 21, characterized in that it is defined in one of claims 1 to 11.