WO2013051901A3 - 신규 아다만탄 유도체 화합물 - Google Patents

신규 아다만탄 유도체 화합물 Download PDF

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Publication number
WO2013051901A3
WO2013051901A3 PCT/KR2012/008103 KR2012008103W WO2013051901A3 WO 2013051901 A3 WO2013051901 A3 WO 2013051901A3 KR 2012008103 W KR2012008103 W KR 2012008103W WO 2013051901 A3 WO2013051901 A3 WO 2013051901A3
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WO
WIPO (PCT)
Prior art keywords
derivative compound
adamantane derivative
novel adamantane
novel
prodrug
Prior art date
Application number
PCT/KR2012/008103
Other languages
English (en)
French (fr)
Other versions
WO2013051901A2 (ko
Inventor
백흥수
김연준
정연수
신송석
박영호
Original Assignee
(주)아모레퍼시픽
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by (주)아모레퍼시픽 filed Critical (주)아모레퍼시픽
Publication of WO2013051901A2 publication Critical patent/WO2013051901A2/ko
Publication of WO2013051901A3 publication Critical patent/WO2013051901A3/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/59—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 신규 아다만탄 유도체 화합물, 이의 이성질체, 이의 약학적으로 허용 가능한 염, 이의 프로드럭, 이의 수화물 또는 이의 용매화물을 개시한다. 상기 신규 아다만탄 유도체 화합물 등은 뛰어난 안드로겐 저해 효과를 가진다.
PCT/KR2012/008103 2011-10-06 2012-10-05 신규 아다만탄 유도체 화합물 WO2013051901A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2011-0101797 2011-10-06
KR1020110101797A KR101957843B1 (ko) 2011-10-06 2011-10-06 신규 아다만탄 유도체 화합물

Publications (2)

Publication Number Publication Date
WO2013051901A2 WO2013051901A2 (ko) 2013-04-11
WO2013051901A3 true WO2013051901A3 (ko) 2013-07-04

Family

ID=48044321

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/008103 WO2013051901A2 (ko) 2011-10-06 2012-10-05 신규 아다만탄 유도체 화합물

Country Status (2)

Country Link
KR (1) KR101957843B1 (ko)
WO (1) WO2013051901A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102529578B1 (ko) 2014-08-29 2023-05-09 (주)아모레퍼시픽 신규 아다만탄 유도체 화합물
WO2016032182A1 (ko) * 2014-08-29 2016-03-03 (주)아모레퍼시픽 신규 아다만탄 유도체 화합물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010032814A (ko) * 1997-12-05 2001-04-25 다비드 에 질레스 아다만탄 유도체
US6242470B1 (en) * 1997-12-05 2001-06-05 Astrazeneca Ab Adamantane derivatives
US6720452B2 (en) * 1999-12-09 2004-04-13 Astrazeneca Ab Adamantane derivatives
US20110086405A1 (en) * 2007-09-27 2011-04-14 Taijiro Tomikawa Method for producing hydroxylated adamantane using cytochrome p450

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100858224B1 (ko) 2008-06-24 2008-09-10 동아제약주식회사 도두 추출물을 함유하는 탈모방지 및 모발 성장촉진 효과를 갖는 모발용 화장료 조성물
KR20110064989A (ko) 2009-12-09 2011-06-15 경북대학교 산학협력단 알파-리포익산을 포함하는 탈모예방 또는 치료용 조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010032814A (ko) * 1997-12-05 2001-04-25 다비드 에 질레스 아다만탄 유도체
US6242470B1 (en) * 1997-12-05 2001-06-05 Astrazeneca Ab Adamantane derivatives
US6720452B2 (en) * 1999-12-09 2004-04-13 Astrazeneca Ab Adamantane derivatives
US20110086405A1 (en) * 2007-09-27 2011-04-14 Taijiro Tomikawa Method for producing hydroxylated adamantane using cytochrome p450

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RHO, H. S. ET AL.: "Studies on depigmenting activities of dihydroxyl benzamide derivatives containing adamantane moiety.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS., vol. 19, 2009, pages 1532 - 1533, XP025994312, DOI: doi:10.1016/j.bmcl.2008.12.106 *

Also Published As

Publication number Publication date
KR20130037405A (ko) 2013-04-16
KR101957843B1 (ko) 2019-03-14
WO2013051901A2 (ko) 2013-04-11

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