WO2013047998A2 - Procédé de préparation d'un implant poreux et implant poreux préparé par le biais de ce procédé - Google Patents

Procédé de préparation d'un implant poreux et implant poreux préparé par le biais de ce procédé Download PDF

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Publication number
WO2013047998A2
WO2013047998A2 PCT/KR2012/006299 KR2012006299W WO2013047998A2 WO 2013047998 A2 WO2013047998 A2 WO 2013047998A2 KR 2012006299 W KR2012006299 W KR 2012006299W WO 2013047998 A2 WO2013047998 A2 WO 2013047998A2
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WIPO (PCT)
Prior art keywords
porous implant
raw material
mold
porous
manufacturing
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PCT/KR2012/006299
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English (en)
Korean (ko)
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WO2013047998A3 (fr
Inventor
이원희
선두훈
김정성
김용화
조유정
Original Assignee
주식회사 코렌텍
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Publication of WO2013047998A2 publication Critical patent/WO2013047998A2/fr
Publication of WO2013047998A3 publication Critical patent/WO2013047998A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/02—Compacting only
    • B22F3/03—Press-moulding apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/10—Sintering only
    • B22F3/105—Sintering only by using electric current other than for infrared radiant energy, laser radiation or plasma ; by ultrasonic bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/10—Sintering only
    • B22F3/11—Making porous workpieces or articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/12—Both compacting and sintering
    • B22F3/14—Both compacting and sintering simultaneously
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C14/00—Alloys based on titanium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C19/00—Alloys based on nickel or cobalt
    • C22C19/07—Alloys based on nickel or cobalt based on cobalt
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C27/00—Alloys based on rhenium or a refractory metal not mentioned in groups C22C14/00 or C22C16/00
    • C22C27/02—Alloys based on vanadium, niobium, or tantalum
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C29/00—Alloys based on carbides, oxides, nitrides, borides, or silicides, e.g. cermets, or other metal compounds, e.g. oxynitrides, sulfides
    • C22C29/16—Alloys based on carbides, oxides, nitrides, borides, or silicides, e.g. cermets, or other metal compounds, e.g. oxynitrides, sulfides based on nitrides

Definitions

  • the present invention relates to a method for manufacturing a porous implant used for medical purposes and to a porous implant prepared therefrom, and more particularly, the mold using a filling step and an energization sintering device to fill a mold with a metal powder or ceramic powder.
  • Implants are artificial devices designed to replace or act as tissues that have been lost, for example implants that are used in human joints, including orthopedic implants, dental implants, spinal cages, knees and hip joints Ore block, bone support and bone graft material used in bone defects.
  • the implant In order for the implant to function, the implant should be well integrated with the surrounding bone tissue, and the difference in Young's modulus between the implant and the surrounding bone tissue should be small so that stress shielding does not occur in the surrounding bone tissue.
  • an implant may be manufactured to have a porosity.
  • the macropore of the porous implant may have bone ingrowth, and thus the porous implant may be fixed as compared to a dense tissue implant. The time required for shortening and the fixing force is increased.
  • the porous implant has a low Young's modulus similar to that of the bone tissue compared to the implant of the dense tissue, so the stress shielding phenomenon does not occur in the surrounding bone tissues after implantation does not cause loss of bone tissue.
  • a method of manufacturing a porous implant conventionally a method of obtaining a porous implant by coating tantalum on the carbon skeleton by the method of chemical vapor deposition (Low Temperature Arc Vapor Deposition) to polyurethane foam (PU foam)
  • Method of manufacturing a porous implant using the method of a method of manufacturing a porous implant by removing the pore precursor after mixing the metal powder and the pore precursor, repeatedly depositing polyurethane foam on a slurry consisting of a metal powder and a binder And a method for producing a porous implant.
  • the chemical vapor deposition method or low temperature arc deposition method for producing a porous implant has to use expensive equipment, there is a problem that the manufacturing process time is increased and the manufacturing cost increases.
  • the method using a pore precursor or a binder there is a problem that the toxic pore precursor or binder and the like remains in the implant even after the preparation of the porous implant.
  • the present invention has been made to solve the above problems,
  • the present invention is orthopedic implants, dental implants, spinal cages, porous implants used in the joint block, artificial bone joints used in the human joint including the knee and hip joints, bone support used in bone support and bone defects It is an object of the present invention to provide a method for preparing and an implant prepared therefrom.
  • the present invention provides a method for producing a porous implant and an implant prepared therefrom, while being firmly fixed to the surrounding bone tissue in a short time, while having a low Young's modulus similar to that of the bone tissue so that stress shielding does not occur in the surrounding bone tissue after transplantation Its purpose is to.
  • an object of the present invention is to provide a method for producing a porous implant that can be produced in a short time at a low temperature by using a current-carrying sintering device and an implant manufactured therefrom.
  • the present invention is implemented by the embodiment having the following configuration to achieve the above object.
  • a method for manufacturing a porous implant according to the present invention includes a filling step of filling a mold made of a metal powder or a ceramic powder; Including a sintering step of applying a predetermined pressure to the raw material filled in the mold using an energizing and sintering device and sintering the raw material at a constant temperature by energizing the raw material; including, shortening the manufacturing time and lowering the manufacturing temperature It features.
  • the pressure applied in the sintering step in the method for producing a porous implant according to the present invention is characterized in that the 100 to 2000kgf / cm2.
  • the temperature for sintering in the sintering step in the method for producing a porous implant according to the invention is characterized in that 800 to 1400 °C.
  • the sintering step is characterized by applying a current of 500 to 2000A and a voltage of 3 to 7V.
  • the metal is titanium, titanium alloy, cobalt chromium, cobalt chromium alloy, tantalum, tantalum alloy, niobium, niobium alloy and titanium nitride It is characterized in that any one or more selected from the group consisting of.
  • the ceramic in the method of manufacturing a porous implant according to the present invention, is characterized in that any one or more selected from the group consisting of tricalcium phosphate, hydroxyapatite, zirconia and alumina.
  • the mold in the method of manufacturing a porous implant according to the present invention, is characterized in that it is made of one or more selected from the group consisting of graphite, tungsten carbide and tungsten.
  • the porous implant according to the present invention is characterized by being manufactured by the manufacturing method according to any one of claims 1 to 4.
  • the porous implant according to the present invention is prepared by the method according to any one of claims 1 to 4, characterized in that having a porosity of 10 to 80%.
  • the present invention can achieve the following effects by the configuration and combination, the use relationship described above in the present embodiment.
  • the present invention can be used in orthopedic implants, dental implants, spinal cages, artificial bone joints used in human joints including knee and hip joints, bone graft material used in the support of bones and bone defects, etc. There is.
  • the present invention is firmly fixed to the surrounding bone tissue in a short time, while having a low Young's modulus similar to the bone tissue has the effect that the stress shielding phenomenon does not occur in the surrounding bone tissue after transplantation.
  • the present invention does not use a pore precursor, a binder or the like at the time of manufacture, there is an effect that is not harmful to the human body.
  • the present invention can be manufactured in a short time at a low temperature by using the energization sintering device has the effect of reducing the manufacturing cost.
  • FIG. 1 is a schematic view of the energization sintering apparatus used in the method for manufacturing a porous implant according to an embodiment of the present invention.
  • Figure 2 is a flow chart showing a method of manufacturing a porous implant according to an embodiment of the present invention.
  • Figure 3 is a photograph of a porous implant produced by the manufacturing method according to an embodiment of the present invention.
  • Figure 4 is a SEM image of the porous implant produced by the manufacturing method according to an embodiment of the present invention.
  • FIG. 5 is a graph showing the results of XRD analysis of the porous implant specimen prepared by the manufacturing method according to an embodiment of the present invention.
  • FIG. 6 is a SEM photograph showing the appearance of osteoblasts attached to the porous implant specimen prepared by the manufacturing method according to an embodiment of the present invention.
  • Figure 1 is a schematic diagram of the energizing and sintering apparatus used in the method for manufacturing a porous implant according to an embodiment of the present invention.
  • the energizing and sintering device 1 is a device for applying a pressure to the raw material (2) made of a powder inserted therein and directly through electricity to sinter the raw material (2) at a predetermined temperature to make a product, the casing (11) , Mold 12, punch 13, pressurizing means 14, power supply unit 15, and control unit (not shown).
  • the casing 11 forms an outer shape of the energizing and sintering device 1 and accommodates the mold 12 and the punch 13 therein, and the inside of the casing 11 is maintained in a vacuum state when manufacturing the product.
  • the mold 12 is configured to accommodate a raw material 2 such as metal powder or ceramic powder, which is a raw material of a product, and is inserted into the casing 11.
  • the mold 12 includes a hollow 121 penetrated up and down, and the punch 13 is installed at the upper and lower ends of the hollow 121 to move upward and downward, respectively.
  • the raw material (2) is located in the space (S) formed by the hollow 121 and the punch 13, the product is manufactured, by deforming the shape of the hollow 121 and punch 13 Products of various shapes can be produced.
  • the mold 12 is formed of an electrically heat-resistant material such as graphite, tungsten oxide or tungsten.
  • the punch 13 is installed in the upper and lower ends of the hollow 121 of the mold 12 so as to be movable, respectively, and the end of the punch 13 is coupled to the pressing means 14 to be described later.
  • the punch 13 is formed of an electrically heat-resistant material such as graphite, tungsten oxide or tungsten.
  • the pressing means 14 is connected to the punch 13, and provides a driving force for allowing the punch 13 to move up and down in the hollow 121 of the mold 12.
  • the power supply unit 15 is configured to generate electricity to allow electricity to flow in the raw material 2 in the mold 12, the power supply unit 15 is the pressing means 14, punch 13, the mold 12 Is electrically connected). When the power supply unit 15 is operated to allow electricity to be supplied to the raw material 2 in the mold 12, heat is generated to cause the raw material 2 to be sintered.
  • the control unit (not shown) is configured to control the overall operation of the energization and sintering apparatus 1, by operating the pressing means 14 to press the raw material 2 or to operate the power supply unit 14 to the raw material (2) It plays a role in making electricity flow.
  • Figure 2 is a flow chart showing a method for manufacturing a porous implant according to an embodiment of the present invention
  • Figure 3 is a photograph of a porous implant prepared by a manufacturing method according to an embodiment of the present invention
  • Figure 4 is a view of the present invention SEM image of the porous implant prepared by the manufacturing method according to an embodiment
  • Figure 5 is a graph showing the XRD analysis of the porous implant specimen prepared by the manufacturing method according to an embodiment of the present invention
  • Figure 6 SEM image showing the appearance of osteoblasts attached to the porous implant specimen prepared by the manufacturing method according to an embodiment of the present invention.
  • a method for manufacturing a porous implant comprises a raw material preparation step (S1) for preparing a raw material (2) made of metal powder or ceramic powder; A mold and punch preparation step (S2) for preparing the mold 12 and the punch 13 to form a space S into which the raw material 2 is inserted; A filling step (S3) of filling the mold 12 with the prepared raw material 2; Sintering step (S4) of applying a constant pressure to the raw material (2) filled in the mold 12 using the energization sintering device (1) and energizing the raw material (2) to sinter the raw material (2) at a predetermined temperature (S4) Including, it is possible to manufacture a porous implant in a short time at a low temperature harmless to the human body has a feature that can reduce the manufacturing cost.
  • the raw material preparation step (S1) is a step of preparing a raw material for manufacturing a porous implant, a metal powder and / or ceramic powder of 10 to 2000 ⁇ m size is used as the raw material and the raw material has a spherical or irregular shape Can have.
  • the metal powder is titanium, titanium alloy, cobalt chromium, cobalt chromium alloy, tantalum, tantalum alloy, niobium, Any one or more metal powder selected from the group consisting of niobium alloy and titanium nitride may be used.
  • the ceramic powder may be any one or more ceramic powders selected from the group consisting of tricalcium phosphate, hydroxyapatite, zirconia, and alumina.
  • the mold and punch preparation step (S2) is a step of preparing the mold 12 and the punch 13 to form a space S into which the raw material 2 is inserted to have a specific shape.
  • the punch 13 is made of an electrically heat-resistant material such as graphite, tungsten oxide or tungsten. Since the raw material 2 is located in the space S formed by the mold 12 and the punch 13 to manufacture a product, the shape of the mold 12 and the punch 13 may be deformed and variously desired. It is possible to manufacture a shaped product.
  • the filling step (S3) is a step of filling the raw material 2 in the mold 12 prepared in the mold and punch preparation step (S2), inserting the raw material into the hollow 121 of the mold 12 and the hollow
  • the punch 13 is coupled to the top and bottom of the 121 so as to be movable.
  • the sintering step (S4) a constant pressure is applied to the raw material 2 filled in the mold 12 using the energization and sintering device 1, and the raw material 2 is energized to sinter the raw material 2 at a predetermined temperature.
  • the step it comprises a mold insertion step (S41), a vacuum composition step (S42), the pressurizing and energizing step (S43).
  • the mold 12 into which the raw material 2 is inserted in the filling step S3 and the punch 13 is inserted into the casing 11 of the energization sintering device 1
  • the punch 13 is connected to the pressing unit 14.
  • the vacuum composition step (S42) is a step of making a vacuum atmosphere inside the casing 11 after the mold insertion step (S41).
  • the pressurizing and energizing step S43 is a step of pressing and energizing the raw material 2 in the mold 12 and sintering at a predetermined temperature, which is controlled by the controller.
  • the pressurizing and energizing step S43 is generated by the control unit operating the pressurizing unit 14 to push the punch 13 to pressurize the raw material 2 in the mold 12 and generate electricity at the power supply unit 15. Electricity flows along the pressurizing portion 14, the punch 12, and the mold 11 to energize the raw material 2.
  • Joule heat is generated, and thus the raw material is locally dissolved and combined.
  • a porous implant having a plurality of pores formed therein.
  • the pressurizing and energizing step S43 it is preferable to apply a pressure of 100 to 2000 kgf / cm 2, sinter at a temperature of 800 to 1400 ° C., and generate electricity of a current of 500 to 2000 A and a voltage of 3 to 7 V. .
  • the present invention includes a porous implant prepared by the method for producing a porous implant.
  • the implant preferably has a porosity of 10 to 80%.
  • Figure 3 is an example of the porous implant (3) prepared by the method of manufacturing the porous implant, as can be seen in the SEM photograph of the porous implant (3) of Figure 4, it can be seen that a number of pores are formed.
  • the porous implant 1 may have various shapes by changing the shape of the mold 12 and the punch 13, as well as the pores by controlling the particle size of the raw material in the manufacturing method, the pressure applied in the sintering step, etc. The size and porosity of the can be easily adjusted.
  • Pressurizing means to pressurize the raw material to 500kgf / cm2, generate a 5V voltage and 1700A current to sinter the raw material to 1100 °C to prepare a cylindrical specimen 13mm in diameter, 25mm in length of the porous implant It was.
  • Specimens of porous implants were prepared under the same conditions as in Example 1 except for using irregular titanium powders of 300 to 400 ⁇ m.
  • Specimens of porous implants were prepared under the same conditions as in Example 1 except that irregular titanium powders of 500 to 600 ⁇ m were used.
  • Specimens of porous implants were prepared under the same conditions as in Example 1 except for using irregular titanium powders of 900 to 1000 ⁇ m.
  • a specimen of a porous implant was prepared under the same conditions as in Example 1 except that the raw material was pressed at 200 kgf / cm 2.
  • a specimen of a porous implant was prepared under the same conditions as in Example 1 except that the raw material was pressed at 1000 kgf / cm 2.
  • Comparative Example 1 is a conventional method for producing a porous implant, 400 ⁇ 500 ⁇ m of irregular titanium powder and a polyvinyl butyral binder is prepared and inserted into the mold, about 500kgf / Pressurized to 2 cm 2 to produce a molded article.
  • Test purpose Measurement of physical properties and manufacturing time of the prepared porous implants
  • Porosity, yield strength and production time of Examples 1 to 6 and Comparative Example 1 were measured and shown in Table 1 below.
  • the yield strength was tested at a test speed of 0.123 mm / min using a universal machine (Instron), and the yield strength was measured from the stress-strain curve obtained after the test.
  • the preparation time was measured for the total time from preparing the raw material to preparing the specimen of the porous implant.
  • Examples 1 to 6 it can be seen that as the raw material size increases, the porosity increases, and as the pressure increases, the porosity decreases and the yield strength increases. From this, the desired porosity and yield strength can be obtained by adjusting the raw material size and pressure. It can be seen that the porous implant can be prepared.
  • Example 1 Table 1 division Manufacture conditions Test evaluation Manufacturing time (hr) Raw material size ( ⁇ m) Pressure (kgf / cm2) Porosity (%) Yield strength (MPa)
  • Example 1 400-500 500 46.9 29.7 2
  • Example 2 300-400 500 49 29.9 2
  • Example 3 500-600 500 43.5 27.7 2
  • Example 4 900-1000 500 40.6 36.4 2
  • Example 5 400-500 200 53.2 8.4 2
  • Example 6 400-500 1000 39.5 80.6 2 Comparative Example 1 400-500 500 47 24.9 30
  • Test Method The specimen of Example 1 (a), the specimen of Example 6 (b) and the raw material (c) were analyzed by XRD and shown in FIG. 5 (using Phillips' X'Pert-MPD System). The specimen of 1 was transplanted into the test animal, removed 7 days later, and photographed by SEM and shown in FIG. 6 (using Hitachi S-2400).
  • Example 1 (a), Example 6 (b) and the raw material (c) are the same, and from this, impurities are produced during the manufacturing process using the energization sintering apparatus. It can be seen that there is no change in chemical composition due to penetration. 6, it can be seen that the osteoblasts penetrate the pores and the pores are filled. From this, it can be seen that the osteoblasts are also attached to the porous implants prepared by using the sintering device.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Mechanical Engineering (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Composite Materials (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne un procédé de préparation d'un implant médical poreux et un implant poreux préparé par le biais de ce procédé. Plus particulièrement, l'invention concerne un procédé de préparation d'un implant poreux et un implant poreux préparé par le biais de ce procédé, le procédé de préparation comprenant : une étape de remplissage destinée à remplir un moule avec une substance comprenant une poudre métallique et une poudre céramique ; et une étape de frittage destinée à appliquer une pression de 100 à 2 000 kgf/cm2 sur la substance remplissant le moule et à générer simultanément un courant de 500 à 2 000 A et une tension de 3 à 7 V en utilisant un dispositif de frittage flash de sorte à permettre à un courant de circuler à travers la substance, permettant de mettre en œuvre le frittage de la substance à une température située dans la plage allant de 800 à 1 400 °C. L'implant poreux est inoffensif dans le corps humain, et peut être préparé en un temps court à de faibles températures, réduisant ainsi les coûts de fabrication.
PCT/KR2012/006299 2011-09-28 2012-08-08 Procédé de préparation d'un implant poreux et implant poreux préparé par le biais de ce procédé WO2013047998A2 (fr)

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KR10-2011-0098209 2011-09-28
KR1020110098209A KR20130034283A (ko) 2011-09-28 2011-09-28 다공성 임플란트의 제조방법 및 그로부터 제조된 다공성 임플란트

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WO2013047998A3 WO2013047998A3 (fr) 2013-05-23

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CN104888269A (zh) * 2015-05-05 2015-09-09 上海大学 提高HA/ZrO2层状复合生物陶瓷材料界面结合力的方法

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* Cited by examiner, † Cited by third party
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CN106312067B (zh) * 2016-10-11 2018-03-20 河海大学 用于放电等离子体无压烧结的石墨模具
CN110201222B (zh) * 2019-07-05 2021-09-07 中南大学 一种促成骨含铷钛钽复合材料及其制备方法和应用
JP7324634B2 (ja) * 2019-07-18 2023-08-10 Ｔｏｗａ株式会社 骨治療用インプラント、骨治療用インプラントの製造方法及び骨治療用インプラント製造装置
CN110614367A (zh) * 2019-10-22 2019-12-27 中南大学 一种界面包覆增强的生物镁基金属陶瓷及其制备方法和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000057987A (ko) * 1999-02-12 2000-09-25 미쯔이 고오헤이 통전소결 방법, 통전소결 장치, 및 통전소결용 몰드
KR20050011576A (ko) * 2003-07-23 2005-01-29 오익현 다공질 티타늄 임플란트
KR20060099912A (ko) * 2005-03-15 2006-09-20 윤태호 생체적합성 및 심미성이 뛰어난 임플란트 및 그 제조방법
KR100873467B1 (ko) * 2007-07-30 2008-12-15 한국생산기술연구원 통전 소결방법 및 장치
KR20110053517A (ko) * 2009-11-16 2011-05-24 한국기계연구원 텅스텐 산화물과 탄소의 혼합분말에 전류를 통전하여 텅스텐계 탄화물을 제조하는 방법
KR101225006B1 (ko) * 2011-09-28 2013-01-22 주식회사 코렌텍 척추체간 유합술용 다공성 케이지 및 그 제조방법

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000057987A (ko) * 1999-02-12 2000-09-25 미쯔이 고오헤이 통전소결 방법, 통전소결 장치, 및 통전소결용 몰드
KR20050011576A (ko) * 2003-07-23 2005-01-29 오익현 다공질 티타늄 임플란트
KR20060099912A (ko) * 2005-03-15 2006-09-20 윤태호 생체적합성 및 심미성이 뛰어난 임플란트 및 그 제조방법
KR100873467B1 (ko) * 2007-07-30 2008-12-15 한국생산기술연구원 통전 소결방법 및 장치
KR20110053517A (ko) * 2009-11-16 2011-05-24 한국기계연구원 텅스텐 산화물과 탄소의 혼합분말에 전류를 통전하여 텅스텐계 탄화물을 제조하는 방법
KR101225006B1 (ko) * 2011-09-28 2013-01-22 주식회사 코렌텍 척추체간 유합술용 다공성 케이지 및 그 제조방법

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104888269A (zh) * 2015-05-05 2015-09-09 上海大学 提高HA/ZrO2层状复合生物陶瓷材料界面结合力的方法

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