WO2012173003A3 - 医療用組織マーカー及びその製造方法 - Google Patents

医療用組織マーカー及びその製造方法 Download PDF

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Publication number
WO2012173003A3
WO2012173003A3 PCT/JP2012/064235 JP2012064235W WO2012173003A3 WO 2012173003 A3 WO2012173003 A3 WO 2012173003A3 JP 2012064235 W JP2012064235 W JP 2012064235W WO 2012173003 A3 WO2012173003 A3 WO 2012173003A3
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WO
WIPO (PCT)
Prior art keywords
marker
medical tissue
manufacturing
same
phospholipid
Prior art date
Application number
PCT/JP2012/064235
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English (en)
French (fr)
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WO2012173003A2 (ja
Inventor
林　秀樹
博哉 畑山
眞紀 藤浪
太郎 豊田
Original Assignee
国立大学法人 千葉大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 国立大学法人 千葉大学 filed Critical 国立大学法人 千葉大学
Priority to JP2013520507A priority Critical patent/JP5959118B2/ja
Priority to EP12801298.6A priority patent/EP2719398B1/en
Priority to US14/126,034 priority patent/US10022459B2/en
Priority to CA2839200A priority patent/CA2839200C/en
Publication of WO2012173003A2 publication Critical patent/WO2012173003A2/ja
Publication of WO2012173003A3 publication Critical patent/WO2012173003A3/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0023—Di-or triarylmethane dye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0084—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion liposome, i.e. bilayered vesicular structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

　臓器外側からでも位置の認識が可能であり、長時間局所的に留まることが可能であって、かつ、マーキングした位置の臓器全体の中での位置の把握が容易となる医療用組織マーカー及びその製造方法を提供する。　そのため、本発明にかかる医療用組織マーカーは、リン脂質及び近赤外蛍光色素が複合して形成されたベシクルと、前記リン脂質及びＸ線造影剤が複合して形成されたエマルションを含み、前記ベシクルと前記エマルションを親水性溶媒に内包させ、乳化剤により複数のカプセルを形成、凝集させたクラスターを有する。
PCT/JP2012/064235 2011-06-13 2012-05-31 医療用組織マーカー及びその製造方法 WO2012173003A2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2013520507A JP5959118B2 (ja) 2011-06-13 2012-05-31 医療用組織マーカー及びその製造方法
EP12801298.6A EP2719398B1 (en) 2011-06-13 2012-05-31 Medical tissue-marker and manufacturing method for same
US14/126,034 US10022459B2 (en) 2011-06-13 2012-05-31 Medical tissue-marker and manufacturing method for the same
CA2839200A CA2839200C (en) 2011-06-13 2012-05-31 Medical tissue-marker and manufacturing method for same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011130901 2011-06-13
JP2011-130901 2011-06-13

Publications (2)

Publication Number Publication Date
WO2012173003A2 WO2012173003A2 (ja) 2012-12-20
WO2012173003A3 true WO2012173003A3 (ja) 2013-02-14

Family

ID=47357558

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2012/064235 WO2012173003A2 (ja) 2011-06-13 2012-05-31 医療用組織マーカー及びその製造方法

Country Status (5)

Country Link
US (1) US10022459B2 (ja)
EP (1) EP2719398B1 (ja)
JP (1) JP5959118B2 (ja)
CA (1) CA2839200C (ja)
WO (1) WO2012173003A2 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3017295B1 (fr) * 2014-02-07 2018-01-12 Guerbet Composition destinee a vectoriser un agent anticancereux
FR3039767B1 (fr) 2015-08-04 2017-09-08 Guerbet Sa Composition destinee a vectoriser un agent anticancereux
JP7048096B2 (ja) 2018-11-14 2022-04-05 株式会社日本医療機器開発機構 開窓用部分を有するステントグラフト

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005263647A (ja) * 2004-03-16 2005-09-29 Konica Minolta Medical & Graphic Inc エマルション粒子含有造影剤
JP2010266295A (ja) * 2009-05-13 2010-11-25 Chiba Univ 蛍光組織マーカー及びその製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK175531B1 (da) * 1986-12-15 2004-11-22 Nexstar Pharmaceuticals Inc Leveringsvehikel med amphiphil-associeret aktiv bestanddel
ATE89171T1 (de) * 1987-06-11 1993-05-15 Kabi Pharmacia Ab Jod enthaltende emulsion.
JP2005220045A (ja) * 2004-02-04 2005-08-18 Konica Minolta Medical & Graphic Inc 蛍光造影剤
JP5099815B2 (ja) 2006-03-03 2012-12-19 甲陽ケミカル株式会社 組織マーカー
JP2008069107A (ja) 2006-09-14 2008-03-27 Pentax Corp 内視鏡用組織蛍光染色剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005263647A (ja) * 2004-03-16 2005-09-29 Konica Minolta Medical & Graphic Inc エマルション粒子含有造影剤
JP2010266295A (ja) * 2009-05-13 2010-11-25 Chiba Univ 蛍光組織マーカー及びその製造方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HARUHIRO ANKO: "Lecithin Haigo lipidol emulsion o Mochiita Kandochu Kagaku Sokusen Ryoho no Kisoteki Kenkyu", JOURNAL OF TOKYO WOMENS MEDICAL UNIVERSITY, vol. 60, no. 12, 1990, pages 999 - 1010, XP008170901 *
See also references of EP2719398A4 *

Also Published As

Publication number Publication date
US10022459B2 (en) 2018-07-17
US20140219924A1 (en) 2014-08-07
EP2719398A2 (en) 2014-04-16
JP5959118B2 (ja) 2016-08-02
CA2839200A1 (en) 2012-12-20
EP2719398B1 (en) 2016-01-20
JPWO2012173003A1 (ja) 2015-02-23
WO2012173003A2 (ja) 2012-12-20
EP2719398A4 (en) 2014-12-31
CA2839200C (en) 2016-06-14

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