WO2012109991A1 - 高分子聚合物的用途及其组成物 - Google Patents
高分子聚合物的用途及其组成物 Download PDFInfo
- Publication number
- WO2012109991A1 WO2012109991A1 PCT/CN2012/071184 CN2012071184W WO2012109991A1 WO 2012109991 A1 WO2012109991 A1 WO 2012109991A1 CN 2012071184 W CN2012071184 W CN 2012071184W WO 2012109991 A1 WO2012109991 A1 WO 2012109991A1
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- WIPO (PCT)
- Prior art keywords
- polymer
- high molecular
- molecular polymer
- fiber
- liquid
- Prior art date
Links
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- 229920006158 high molecular weight polymer Polymers 0.000 title abstract 2
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- 208000027418 Wounds and injury Diseases 0.000 claims 1
- PFTAWBLQPZVEMU-UHFFFAOYSA-N catechin Chemical compound OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UHFFFAOYSA-N 0.000 claims 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims 1
- 235000005487 catechin Nutrition 0.000 claims 1
- 229950001002 cianidanol Drugs 0.000 claims 1
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- 229940041678 oral spray Drugs 0.000 claims 1
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- -1 smear Substances 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 229920002994 synthetic fiber Polymers 0.000 abstract 1
- 239000012209 synthetic fiber Substances 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 description 23
- 231100000614 poison Toxicity 0.000 description 14
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- 235000011389 fruit/vegetable juice Nutrition 0.000 description 10
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- 235000015110 jellies Nutrition 0.000 description 2
- 239000008274 jelly Substances 0.000 description 2
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- 231100000167 toxic agent Toxicity 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
- A23L33/24—Cellulose or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
- A23L33/28—Substances of animal origin, e.g. gelatin or collagen
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
Definitions
- the present invention relates to a polymer?
- polymer fibers and polymers such as natural biopolymer materials, such as collagen, gelatin, hyaluronic acid, chitin and chitosan and their derivatives, and other animal-derived polymer fibers and polymers, or Plant-derived polymer fibers and polymers such as alginate and cellulose and its derivatives, because of their good biocompatibility and biodegradability, and containing hydrolyzable bonds, they can usually be decomposed in living organisms. For small molecules, they are excreted via kidney filtration or metabolic procedures.
- these polymer fibers and polymers are added to foods to help users feel fullness after eating, while reducing the amount of food to meet the needs of light body shaping, and because they have a large amount of fiber. It can promote gastrointestinal motility and is therefore often used as a softener (such as Sterculia BP and Frangula BPC) to help patients with bowel movements to have a smooth bowel movement.
- a softener such as Sterculia BP and Frangula BPC
- An object of the present invention is to provide a novel use of a high molecular polymer which can absorb a body liquid (for example, a digestive juice) present in a living body or a liquid or a solution in which a harmful substance such as a toxin or an irritating ingredient which enters a living body exists. That is, a new use of indirect adsorption of toxic substances by directly adsorbing a liquid or a solution, reducing the digestive juice in the body and reducing the body's digestion and absorption of food, and It also helps to remove these harmful substances to protect the organism from harmful substances such as toxins or irritating substances. Because of their good biocompatibility, these polymers are even taken into the living body. It does not pose a health hazard to the organism.
- a body liquid for example, a digestive juice
- the invention applies the characteristics of the polymer polymer capable of adsorbing liquid, and is applied to indirectly adsorbing and absorbing the body fluid (for example, digestive juice) existing in the living body or the liquid, the solution or the harmful toxic substances contained therein into the living body.
- body fluid for example, digestive juice
- the high molecular polymer of the present invention comprises a polymer fiber, a natural fiber, a rayon fiber, a polymer absorber, and the like.
- the natural fiber refers to Sterculia BP or Frangula BPC.
- Etc. in the preferred case, natural fiber refers to collagen, cellulose, chitin, chitosan, which have a highly interlaced molecular structure that can be used in alcohol, alcohol, coffee.
- a liquid or solution in which caffeine, theine, uric acid, lipids, cholesterol, strong acids and alkalis may cause harm to the body (indirect adsorption of liquid by direct adsorption of liquid or solution)
- the new use of the substance properties is adsorbed and discharged to the organism to reduce the absorption of the substance by the organism, further reducing the toxic effects, side effects or adverse effects of the substance on the organism, In order to achieve the effect of protecting cells of living organ tissues.
- Another object of the present invention is to provide a polymer polymer composition which binds the high molecular polymer to at least one biocompatible compost, for example, the excipient a shell layer formed, and the biocompatible excipient shell layer has a plurality of microscopic pores, so that when the organism swallows the polymer, the biocompatible form
- the agent can protect the polymer from damage by body fluids or pH of the organism.
- the polymer is coated with a biocompatible excipient to chew.
- the swallowing method enters the living body, and the harmful substances in the living body are absorbed by the d and pores of the biocompatible excipient and are absorbed by the high molecular polymer, and the high molecular polymer has a staggered shape. It can form many tiny pores, so the molecules of harmful substances can be fixed in the pores, thereby reducing the total amount of harmful substances in contact with the living tissue and avoiding the harmful substances.
- the poison of the object is to provide a polymer polymer composition which binds the high mo
- the adsorbed liquid is a common property of most high molecular polymers, by using a polymer?
- the common property of the adsorbed liquid will indirectly adsorb the body fluid (such as digestive juice) present in the organism, reduce the digestive juice in the body and reduce the body's digestion and absorption of food, or assist in the liquid involved in the body.
- the absorption and discharge of harmful toxic substances contained in the product can reduce the research and development costs and practical application restrictions that are caused by the different adsorption capacities of the high molecular polymers for various substances.
- Fig. 1 is a schematic cross-sectional view showing a polymer composition of the present invention.
- the present invention provides a new use of a polymer, which utilizes a polymer to adsorb a body fluid (such as a digestive juice) present in a living body, a liquid or a solution of a harmful substance such as a toxin or an irritating component in the living body.
- a body fluid such as a digestive juice
- a harmful substance such as a toxin or an irritating component in the living body.
- the invention applies the characteristics of the polymer polymer capable of adsorbing liquid, and is applied to a new use and a composition thereof for indirectly adsorbing, absorbing and discharging a body fluid, a liquid, a solution or a harmful toxic substance contained therein or entering the living body. Since the adsorption liquid is a common characteristic of most high molecular polymers, the absorption and discharge of harmful toxic substances contained in the indirect adsorption liquid can be suppressed by utilizing the common characteristics of the high molecular polymer adsorption liquid. R&D costs and practical application limits that increase the adsorption capacity of each substance.
- the high molecular polymer of the present invention comprises a polymer fiber, a natural fiber, a rayon fiber and a polymer absorber, wherein the natural fiber is selected from the group consisting of: Sterculia BP, Frangula BPC, collagen, cellulose, chitin and chitosan.
- Sterculia BP Sterculia BP
- Frangula BPC Frangula BPC
- collagen collagen
- cellulose chitin
- chitosan chitosan
- Sterculia BP is used as a substrate and a coffee that is commonly consumed by the general public is taken as an example to illustrate the new use of the high molecular polymer of the present invention, wherein Sterculia BP is a high molecular polymer of a polymer fiber. It can be used alone or in combination with other polymer materials with adsorption characteristics.
- Sterculia BP and Frangula BPC are mixed at a weight percentage of 25% and 75% to form a polymer fiber mixture (hereinafter referred to as polymer). Fiber), 1 gram of this polymer fiber mixture is uniformly mixed in 30 ml of commercially available espresso coffee to form a polymer fiber-coffee mixture.
- This polymer fiber-coffee mixture has begun to appear after 5 minutes. In a viscous state, after 10 minutes, the viscosity is increased and converted into a semi-solid colloidal state. Subsequently, the viscous properties of the polymer fiber-coffee mixture will continue to increase until the 30th minute, the polymer fiber- The coffee mixture has become a state similar to the sand tea sauce and has almost no fluidity, and as can be seen from the examples, Once the user uses the polymer fiber-coffee mixture, the caffeine absorbed into the body is absorbed into the polymer fiber-coffee mixture as the coffee is absorbed, which causes the caffeine and the human cells to have a barrier effect. According to this, the damage of caffeine to the human body can be reduced.
- the polymer fibers Sterculia BP and Frangula BPC as described in the present embodiment may be used in any ratio, or may be used alone or in combination with other high molecular polymers.
- the kelp which is commonly consumed by the general public is taken as an example to illustrate the effect of the polymer fiber (Sterculia BP and Frangula BPC mixed in a weight percentage of 25% and 75%) in the first embodiment for absorbing and adsorbing cola.
- This polymer fiber-cola mixture has begun to show a viscous state after 5 minutes, after 10 minutes. , the viscosity is improved and about 95% of the cola has been absorbed by the polymer fiber and the polymer, and almost no flow Dynamic, at 30 minutes, the polymer fiber-Cola mixture is almost completely solid. It is obvious that this polymer fiber can quickly absorb the absorbed liquid and absorb it in a short time. In the process of absorbing liquid, It will absorb the toxic or harmful substances in the liquid and thus protect the body from contact with these harmful substances and be harmed.
- This embodiment illustrates the effect of the polymer fiber in the first embodiment on the absorption of adsorbed alcohol.
- the 1 gram polymer fiber mixture is uniformly added to 30 ml of sorghum wine (alcohol content 58%) to form a polymer fiber-sorghum. After 5 minutes, the polymer fiber-sorghum mixture began to produce viscosity. After 10 minutes, the polymer fiber-sorghum mixture appeared in a gel state, and the polymer fiber-sorghum was up to 20 minutes and 30 minutes. The type of the mixture starts to be near the solidified jelly or paste.
- the polymer fiber-sorghum mixture is already in a form that is unable to produce a flow behavior and is close to a solid state, so it can be seen that if These components, which contain harmful substances such as alcohol, can be sufficiently absorbed by the polymer fibers and polymers after entering the organism, and reduce the chances of such harmful substances such as ethanol coming into contact with human cells or even causing poisoning.
- Sterculia BP also exhibits similar adsorption and gradually causes the polymer sorghum mixture to exhibit a semi-flow or a non-flowing paste or near solid state.
- the sorghum wine (58% alcohol content) was uniformly stirred to form a polymer fiber-sorghum wine mixture. After 5 minutes, the polymer fiber-sorghum mixture began to produce viscosity. After 10 minutes, the polymer fiber-sorghum mixture appeared glue.
- the form of the polymer fiber-sorghum mixture begins to be near the solidified jelly or paste, and finally after mixing for one hour, the polymer fiber-sorghum mixture It has been a type that is unable to produce a flow behavior and is close to a solid state. Therefore, if these components containing harmful substances such as alcohol are in the entering organism, they can be sufficiently absorbed by the polymer fibers and the polymer, and the ethanol is reduced. The opportunity for harmful substances to come into contact with human cells and even produce poison.
- the high molecular polymer of the invention can be made into a chewable dosage form, and the consumer can take it by means of chewing and eating, especially for those consumers who often have to drink or entertain, if they are drinking or entertaining, You can take these high-molecular polymers first. Once you start drinking, the polymer that stays in the digestive tract will start to absorb the ethanol in the wine. So, there will not be too much ethanol to pass through the cells of the digestive tract wall. Absorbed by the body, so it does not endure too much ethanol on the body The poison, the same way can also be applied to patients who are dependent on drugs or stimulating ingredients such as caffeine and tea; moreover, the polymer of the present invention can be used for acid and alkali.
- the acid-base liquid can be absorbed by using the polymer of the present invention, and on the one hand, strong acid and alkali can be avoided for the tissue cells.
- the damage caused, on the other hand, can quickly relieve the body's discomfort due to acid and alkali substances.
- the high molecular polymer of the present invention can be mixed with a biocompatible excipient to prepare into a dosage form of a tablet, a capsule, a microparticle, a spray, an emulsion or an injection, and is injected, smeared, orally. Or sprayed to the living body; as shown in FIG.
- the high molecular polymer of the present invention forms a high molecular polymer composition 1 in which the high molecular polymer layer 11 is coated a shell layer 12 having a biocompatible excipient, and the shell layer 12 has a plurality of minute pores, so that toxins or irritants can enter the polymer composition 1 from the pores and are It is trapped in the slit formed by the interlacing of the high molecular polymer in the polymer layer 11, and is less likely to flow out of the pores of the outer shell layer 12 and come into contact with the living tissue to cause damage.
- the present invention utilizes the rapid absorption of a polymer or a solution of a liquid or a solution of a harmful substance such as a toxin or an irritant (a new use of indirect adsorption of a toxic substance by directly adsorbing a liquid or a solution).
- a harmful substance such as a toxin or an irritant
- the adsorbed liquid is a common characteristic of most high molecular polymers, the absorption and discharge of harmful toxic substances contained in the indirect adsorbed liquid can be suppressed by utilizing the common characteristics of the polymer adsorbing liquid.
- the R&D cost and practical application limits of the compound increase the adsorption capacity of each substance.
- the present invention provides a new use of a high molecular polymer which can absorb body fluids present in a living body
- the invention applies the characteristics of the polymer polymer capable of adsorbing liquid, and is applied to indirectly adsorbing and absorbing the body fluid (for example, digestive juice) existing in the living body or the liquid, the solution or the harmful toxic substances contained therein into the living body.
- body fluid for example, digestive juice
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Medicinal Chemistry (AREA)
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- Medical Informatics (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Description
Claims
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2013009394A MX349794B (es) | 2011-02-16 | 2012-02-16 | Uso de un polímero de alto peso molecular y composición que lo incluye. |
CA2827510A CA2827510C (en) | 2011-02-16 | 2012-02-16 | Use for high-molecular-weight polymer and composition including same |
BR112013020599-7A BR112013020599B1 (pt) | 2011-02-16 | 2012-02-16 | Uso de uma composição, e composição |
ES12747509T ES2776637T3 (es) | 2011-02-16 | 2012-02-16 | Polímero de alto peso molecular para utilizar |
CN2012800080490A CN103402378A (zh) | 2011-02-16 | 2012-02-16 | 高分子聚合物的用途及其组成物 |
AU2012217543A AU2012217543B2 (en) | 2011-02-16 | 2012-02-16 | Use for high-molecular-weight polymer and composition including same |
EP12747509.3A EP2676555B1 (en) | 2011-02-16 | 2012-02-16 | High-molecular-weight polymer for use |
NZ614587A NZ614587B2 (en) | 2011-02-16 | 2012-02-16 | Use for high-molecular-weight polymer and composition including same |
RU2013142189/15A RU2587718C2 (ru) | 2011-02-16 | 2012-02-16 | Способ защиты организма от поражения токсичными или вредоносными веществами и композиция |
PL12747509T PL2676555T3 (pl) | 2011-02-16 | 2012-02-16 | Polimer o dużym ciężarze cząsteczkowym do zastosowania |
SG2013064035A SG193235A1 (en) | 2011-02-16 | 2012-02-16 | Use for high-molecular-weight polymer and composition including same |
JP2013553775A JP5991994B2 (ja) | 2011-02-16 | 2012-02-16 | 高分子重合体の使用方法およびその組成物 |
DK12747509.3T DK2676555T3 (da) | 2011-02-16 | 2012-02-16 | Polymer med høj molekylvægt til anvendelse |
KR1020137023947A KR102008029B1 (ko) | 2011-02-16 | 2012-02-16 | 고분자량 폴리머의 용도 및 이를 포함한 조성물 |
US13/920,554 US10695388B2 (en) | 2011-02-16 | 2013-06-18 | High molecular weight polymeric composition and a new usage of the high-molecular weight polymeric composition |
IL227976A IL227976A0 (en) | 2011-02-16 | 2013-08-15 | Use for a high molecular weight polymer and a preparation containing it |
CU2013000113A CU20130113A7 (es) | 2011-02-16 | 2013-08-16 | Uso de polímero de alto peso molecular y composiciones que incluyen el mismo |
ZA2013/06941A ZA201306941B (en) | 2011-02-16 | 2013-09-16 | Use for high-molecular-weight polymer and composition including same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011100392786A CN102641496A (zh) | 2011-02-16 | 2011-02-16 | 高分子聚合物的新用途及其组成物 |
CN201110039278.6 | 2011-02-16 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US13/920,554 Continuation-In-Part US10695388B2 (en) | 2011-02-16 | 2013-06-18 | High molecular weight polymeric composition and a new usage of the high-molecular weight polymeric composition |
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WO2012109991A1 true WO2012109991A1 (zh) | 2012-08-23 |
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PCT/CN2012/071184 WO2012109991A1 (zh) | 2011-02-16 | 2012-02-16 | 高分子聚合物的用途及其组成物 |
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US (1) | US10695388B2 (zh) |
EP (1) | EP2676555B1 (zh) |
JP (1) | JP5991994B2 (zh) |
KR (1) | KR102008029B1 (zh) |
CN (2) | CN102641496A (zh) |
AU (1) | AU2012217543B2 (zh) |
BR (1) | BR112013020599B1 (zh) |
CA (1) | CA2827510C (zh) |
CL (1) | CL2013002360A1 (zh) |
CO (1) | CO6801797A2 (zh) |
CR (1) | CR20130463A (zh) |
CU (1) | CU20130113A7 (zh) |
DK (1) | DK2676555T3 (zh) |
DO (1) | DOP2013000187A (zh) |
ES (1) | ES2776637T3 (zh) |
HU (1) | HUE048333T2 (zh) |
IL (1) | IL227976A0 (zh) |
MX (1) | MX349794B (zh) |
MY (1) | MY166779A (zh) |
PL (1) | PL2676555T3 (zh) |
PT (1) | PT2676555T (zh) |
RU (1) | RU2587718C2 (zh) |
SG (1) | SG193235A1 (zh) |
WO (1) | WO2012109991A1 (zh) |
ZA (1) | ZA201306941B (zh) |
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JP5926533B2 (ja) * | 2011-10-27 | 2016-05-25 | キヤノン株式会社 | 眼科装置 |
TWI733810B (zh) * | 2016-05-19 | 2021-07-21 | 美商迪卡提諾股份有限公司 | 吸附咖啡因之材料、吸附咖啡因之系統、去咖啡因之系統及自溶液中去除咖啡因之相關方法 |
CN109219358A (zh) * | 2016-06-01 | 2019-01-15 | 辛绍祺 | 用于降低有害/毒性物质的消化率或吸收率的食用组合物 |
TWI725030B (zh) * | 2016-06-01 | 2021-04-21 | 辛紹祺 | 降低食品/飲料消化率/吸收率或減少消化液之方法及組合物 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1308899A (zh) * | 2001-02-21 | 2001-08-22 | 图布新 | 食用纤维素 |
CN1806700A (zh) * | 2005-01-21 | 2006-07-26 | 陈胜利 | 有害物质天然净化剂 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2069560C1 (ru) * | 1992-02-27 | 1996-11-27 | Ленинградское хозрасчетное научно-производственное предприятие "Медход" | Вещество для адсорбции ядов |
SE9300139L (sv) | 1993-01-19 | 1994-07-20 | Medicarb Ab | Framställning av ett nytt läkemedel |
JP3281733B2 (ja) * | 1994-10-11 | 2002-05-13 | 三井農林株式会社 | 低カフェイン茶ポリフェノールの製造法 |
CN1235832A (zh) * | 1998-05-18 | 1999-11-24 | 威海经济技术开发区中海经济发展公司 | 复方壳聚糖 |
US5997905A (en) | 1998-09-04 | 1999-12-07 | Mcneil-Ppc | Preparation of pharmaceutically active particles |
EP2324861A1 (en) * | 2000-11-20 | 2011-05-25 | Sorbent Therapeutics, Inc. | In vivo use of water absorbent polymers |
CA2504706A1 (en) | 2002-11-04 | 2004-05-21 | Nycomed Danmark Aps | Coating of a particulate material with an organic solvent-based coating composition |
JP2004275251A (ja) * | 2003-03-13 | 2004-10-07 | Toray Ind Inc | 体液浄化カラム用繊維素材及びその製造方法 |
RU2005134364A (ru) | 2003-04-08 | 2006-06-10 | Проджиникс Фармасьютикалз, Инк. (Us) | Комбинированное лечение запора |
KR20050120832A (ko) * | 2004-06-21 | 2005-12-26 | 김태주 | 항균성 부직포 |
DE102005005573B4 (de) * | 2005-02-07 | 2007-03-08 | Lts Lohmann Therapie-Systeme Ag | Hydrophiles Gelsystem zur Hautpflege auf Basis von Karaya-Gummi |
JP2008001829A (ja) * | 2006-06-23 | 2008-01-10 | Tetsusei Rin | 酸処理キチン・キトサンおよびキチン・キトサンペースト |
US7799347B2 (en) | 2006-09-07 | 2010-09-21 | Chondrex Inc. | Endotoxin-adsorbent for the prevention and treatment of autoimmune diseases |
US20080095881A1 (en) * | 2006-09-29 | 2008-04-24 | Garden Of Life, Inc. | Fiber and natural chelator composition suitable for effective detoxification |
KR20080035729A (ko) * | 2006-10-20 | 2008-04-24 | 현대약품 주식회사 | 카페인 저감 녹차 음료 및 그 제조방법 |
US20090061008A1 (en) * | 2007-08-30 | 2009-03-05 | Levy Mark M | Fiber/granule complex for treatment of the gi tract |
US9457048B2 (en) * | 2008-02-05 | 2016-10-04 | Wellosophy Corporation | Absorbent ingestible agents and associated methods of manufacture and use |
KR101804354B1 (ko) * | 2008-11-18 | 2017-12-04 | 젤레시스 엘엘씨 | 체중 관리 및 혈당 조절 개선을 위한 방법 및 조성물 |
CN101548757B (zh) * | 2009-05-08 | 2011-06-29 | 西北农林科技大学 | 拐枣不溶性膳食纤维及其制备方法 |
CN201710674U (zh) * | 2010-03-05 | 2011-01-19 | 辛绍祺 | 吸附隔离装置 |
CN102138645B (zh) * | 2010-11-22 | 2013-03-13 | 青岛田瑞生态科技有限公司 | 一种甲壳质蛋鸡饲料及其制造、使用方法 |
-
2011
- 2011-02-16 CN CN2011100392786A patent/CN102641496A/zh active Pending
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2012
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- 2012-02-16 MX MX2013009394A patent/MX349794B/es active IP Right Grant
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- 2012-02-16 DK DK12747509.3T patent/DK2676555T3/da active
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- 2012-02-16 KR KR1020137023947A patent/KR102008029B1/ko active IP Right Grant
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- 2012-02-16 WO PCT/CN2012/071184 patent/WO2012109991A1/zh active Application Filing
- 2012-02-16 RU RU2013142189/15A patent/RU2587718C2/ru active
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1308899A (zh) * | 2001-02-21 | 2001-08-22 | 图布新 | 食用纤维素 |
CN1806700A (zh) * | 2005-01-21 | 2006-07-26 | 陈胜利 | 有害物质天然净化剂 |
Non-Patent Citations (1)
Title |
---|
See also references of EP2676555A4 * |
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