WO2012109991A1 - 高分子聚合物的用途及其组成物 - Google Patents

高分子聚合物的用途及其组成物 Download PDF

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Publication number
WO2012109991A1
WO2012109991A1 PCT/CN2012/071184 CN2012071184W WO2012109991A1 WO 2012109991 A1 WO2012109991 A1 WO 2012109991A1 CN 2012071184 W CN2012071184 W CN 2012071184W WO 2012109991 A1 WO2012109991 A1 WO 2012109991A1
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WIPO (PCT)
Prior art keywords
polymer
high molecular
molecular polymer
fiber
liquid
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PCT/CN2012/071184
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English (en)
French (fr)
Inventor
辛绍祺
Original Assignee
Hsin Shaochi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority to PL12747509T priority Critical patent/PL2676555T3/pl
Priority to DK12747509.3T priority patent/DK2676555T3/da
Priority to CA2827510A priority patent/CA2827510C/en
Priority to BR112013020599-7A priority patent/BR112013020599B1/pt
Priority to ES12747509T priority patent/ES2776637T3/es
Priority to CN2012800080490A priority patent/CN103402378A/zh
Priority to AU2012217543A priority patent/AU2012217543B2/en
Application filed by Hsin Shaochi filed Critical Hsin Shaochi
Priority to NZ614587A priority patent/NZ614587B2/en
Priority to RU2013142189/15A priority patent/RU2587718C2/ru
Priority to EP12747509.3A priority patent/EP2676555B1/en
Priority to SG2013064035A priority patent/SG193235A1/en
Priority to JP2013553775A priority patent/JP5991994B2/ja
Priority to MX2013009394A priority patent/MX349794B/es
Priority to KR1020137023947A priority patent/KR102008029B1/ko
Publication of WO2012109991A1 publication Critical patent/WO2012109991A1/zh
Priority to US13/920,554 priority patent/US10695388B2/en
Priority to IL227976A priority patent/IL227976A0/en
Priority to CU2013000113A priority patent/CU20130113A7/es
Priority to ZA2013/06941A priority patent/ZA201306941B/en

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/24—Cellulose or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/28—Substances of animal origin, e.g. gelatin or collagen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)

Definitions

  • the present invention relates to a polymer?
  • polymer fibers and polymers such as natural biopolymer materials, such as collagen, gelatin, hyaluronic acid, chitin and chitosan and their derivatives, and other animal-derived polymer fibers and polymers, or Plant-derived polymer fibers and polymers such as alginate and cellulose and its derivatives, because of their good biocompatibility and biodegradability, and containing hydrolyzable bonds, they can usually be decomposed in living organisms. For small molecules, they are excreted via kidney filtration or metabolic procedures.
  • these polymer fibers and polymers are added to foods to help users feel fullness after eating, while reducing the amount of food to meet the needs of light body shaping, and because they have a large amount of fiber. It can promote gastrointestinal motility and is therefore often used as a softener (such as Sterculia BP and Frangula BPC) to help patients with bowel movements to have a smooth bowel movement.
  • a softener such as Sterculia BP and Frangula BPC
  • An object of the present invention is to provide a novel use of a high molecular polymer which can absorb a body liquid (for example, a digestive juice) present in a living body or a liquid or a solution in which a harmful substance such as a toxin or an irritating ingredient which enters a living body exists. That is, a new use of indirect adsorption of toxic substances by directly adsorbing a liquid or a solution, reducing the digestive juice in the body and reducing the body's digestion and absorption of food, and It also helps to remove these harmful substances to protect the organism from harmful substances such as toxins or irritating substances. Because of their good biocompatibility, these polymers are even taken into the living body. It does not pose a health hazard to the organism.
  • a body liquid for example, a digestive juice
  • the invention applies the characteristics of the polymer polymer capable of adsorbing liquid, and is applied to indirectly adsorbing and absorbing the body fluid (for example, digestive juice) existing in the living body or the liquid, the solution or the harmful toxic substances contained therein into the living body.
  • body fluid for example, digestive juice
  • the high molecular polymer of the present invention comprises a polymer fiber, a natural fiber, a rayon fiber, a polymer absorber, and the like.
  • the natural fiber refers to Sterculia BP or Frangula BPC.
  • Etc. in the preferred case, natural fiber refers to collagen, cellulose, chitin, chitosan, which have a highly interlaced molecular structure that can be used in alcohol, alcohol, coffee.
  • a liquid or solution in which caffeine, theine, uric acid, lipids, cholesterol, strong acids and alkalis may cause harm to the body (indirect adsorption of liquid by direct adsorption of liquid or solution)
  • the new use of the substance properties is adsorbed and discharged to the organism to reduce the absorption of the substance by the organism, further reducing the toxic effects, side effects or adverse effects of the substance on the organism, In order to achieve the effect of protecting cells of living organ tissues.
  • Another object of the present invention is to provide a polymer polymer composition which binds the high molecular polymer to at least one biocompatible compost, for example, the excipient a shell layer formed, and the biocompatible excipient shell layer has a plurality of microscopic pores, so that when the organism swallows the polymer, the biocompatible form
  • the agent can protect the polymer from damage by body fluids or pH of the organism.
  • the polymer is coated with a biocompatible excipient to chew.
  • the swallowing method enters the living body, and the harmful substances in the living body are absorbed by the d and pores of the biocompatible excipient and are absorbed by the high molecular polymer, and the high molecular polymer has a staggered shape. It can form many tiny pores, so the molecules of harmful substances can be fixed in the pores, thereby reducing the total amount of harmful substances in contact with the living tissue and avoiding the harmful substances.
  • the poison of the object is to provide a polymer polymer composition which binds the high mo
  • the adsorbed liquid is a common property of most high molecular polymers, by using a polymer?
  • the common property of the adsorbed liquid will indirectly adsorb the body fluid (such as digestive juice) present in the organism, reduce the digestive juice in the body and reduce the body's digestion and absorption of food, or assist in the liquid involved in the body.
  • the absorption and discharge of harmful toxic substances contained in the product can reduce the research and development costs and practical application restrictions that are caused by the different adsorption capacities of the high molecular polymers for various substances.
  • Fig. 1 is a schematic cross-sectional view showing a polymer composition of the present invention.
  • the present invention provides a new use of a polymer, which utilizes a polymer to adsorb a body fluid (such as a digestive juice) present in a living body, a liquid or a solution of a harmful substance such as a toxin or an irritating component in the living body.
  • a body fluid such as a digestive juice
  • a harmful substance such as a toxin or an irritating component in the living body.
  • the invention applies the characteristics of the polymer polymer capable of adsorbing liquid, and is applied to a new use and a composition thereof for indirectly adsorbing, absorbing and discharging a body fluid, a liquid, a solution or a harmful toxic substance contained therein or entering the living body. Since the adsorption liquid is a common characteristic of most high molecular polymers, the absorption and discharge of harmful toxic substances contained in the indirect adsorption liquid can be suppressed by utilizing the common characteristics of the high molecular polymer adsorption liquid. R&D costs and practical application limits that increase the adsorption capacity of each substance.
  • the high molecular polymer of the present invention comprises a polymer fiber, a natural fiber, a rayon fiber and a polymer absorber, wherein the natural fiber is selected from the group consisting of: Sterculia BP, Frangula BPC, collagen, cellulose, chitin and chitosan.
  • Sterculia BP Sterculia BP
  • Frangula BPC Frangula BPC
  • collagen collagen
  • cellulose chitin
  • chitosan chitosan
  • Sterculia BP is used as a substrate and a coffee that is commonly consumed by the general public is taken as an example to illustrate the new use of the high molecular polymer of the present invention, wherein Sterculia BP is a high molecular polymer of a polymer fiber. It can be used alone or in combination with other polymer materials with adsorption characteristics.
  • Sterculia BP and Frangula BPC are mixed at a weight percentage of 25% and 75% to form a polymer fiber mixture (hereinafter referred to as polymer). Fiber), 1 gram of this polymer fiber mixture is uniformly mixed in 30 ml of commercially available espresso coffee to form a polymer fiber-coffee mixture.
  • This polymer fiber-coffee mixture has begun to appear after 5 minutes. In a viscous state, after 10 minutes, the viscosity is increased and converted into a semi-solid colloidal state. Subsequently, the viscous properties of the polymer fiber-coffee mixture will continue to increase until the 30th minute, the polymer fiber- The coffee mixture has become a state similar to the sand tea sauce and has almost no fluidity, and as can be seen from the examples, Once the user uses the polymer fiber-coffee mixture, the caffeine absorbed into the body is absorbed into the polymer fiber-coffee mixture as the coffee is absorbed, which causes the caffeine and the human cells to have a barrier effect. According to this, the damage of caffeine to the human body can be reduced.
  • the polymer fibers Sterculia BP and Frangula BPC as described in the present embodiment may be used in any ratio, or may be used alone or in combination with other high molecular polymers.
  • the kelp which is commonly consumed by the general public is taken as an example to illustrate the effect of the polymer fiber (Sterculia BP and Frangula BPC mixed in a weight percentage of 25% and 75%) in the first embodiment for absorbing and adsorbing cola.
  • This polymer fiber-cola mixture has begun to show a viscous state after 5 minutes, after 10 minutes. , the viscosity is improved and about 95% of the cola has been absorbed by the polymer fiber and the polymer, and almost no flow Dynamic, at 30 minutes, the polymer fiber-Cola mixture is almost completely solid. It is obvious that this polymer fiber can quickly absorb the absorbed liquid and absorb it in a short time. In the process of absorbing liquid, It will absorb the toxic or harmful substances in the liquid and thus protect the body from contact with these harmful substances and be harmed.
  • This embodiment illustrates the effect of the polymer fiber in the first embodiment on the absorption of adsorbed alcohol.
  • the 1 gram polymer fiber mixture is uniformly added to 30 ml of sorghum wine (alcohol content 58%) to form a polymer fiber-sorghum. After 5 minutes, the polymer fiber-sorghum mixture began to produce viscosity. After 10 minutes, the polymer fiber-sorghum mixture appeared in a gel state, and the polymer fiber-sorghum was up to 20 minutes and 30 minutes. The type of the mixture starts to be near the solidified jelly or paste.
  • the polymer fiber-sorghum mixture is already in a form that is unable to produce a flow behavior and is close to a solid state, so it can be seen that if These components, which contain harmful substances such as alcohol, can be sufficiently absorbed by the polymer fibers and polymers after entering the organism, and reduce the chances of such harmful substances such as ethanol coming into contact with human cells or even causing poisoning.
  • Sterculia BP also exhibits similar adsorption and gradually causes the polymer sorghum mixture to exhibit a semi-flow or a non-flowing paste or near solid state.
  • the sorghum wine (58% alcohol content) was uniformly stirred to form a polymer fiber-sorghum wine mixture. After 5 minutes, the polymer fiber-sorghum mixture began to produce viscosity. After 10 minutes, the polymer fiber-sorghum mixture appeared glue.
  • the form of the polymer fiber-sorghum mixture begins to be near the solidified jelly or paste, and finally after mixing for one hour, the polymer fiber-sorghum mixture It has been a type that is unable to produce a flow behavior and is close to a solid state. Therefore, if these components containing harmful substances such as alcohol are in the entering organism, they can be sufficiently absorbed by the polymer fibers and the polymer, and the ethanol is reduced. The opportunity for harmful substances to come into contact with human cells and even produce poison.
  • the high molecular polymer of the invention can be made into a chewable dosage form, and the consumer can take it by means of chewing and eating, especially for those consumers who often have to drink or entertain, if they are drinking or entertaining, You can take these high-molecular polymers first. Once you start drinking, the polymer that stays in the digestive tract will start to absorb the ethanol in the wine. So, there will not be too much ethanol to pass through the cells of the digestive tract wall. Absorbed by the body, so it does not endure too much ethanol on the body The poison, the same way can also be applied to patients who are dependent on drugs or stimulating ingredients such as caffeine and tea; moreover, the polymer of the present invention can be used for acid and alkali.
  • the acid-base liquid can be absorbed by using the polymer of the present invention, and on the one hand, strong acid and alkali can be avoided for the tissue cells.
  • the damage caused, on the other hand, can quickly relieve the body's discomfort due to acid and alkali substances.
  • the high molecular polymer of the present invention can be mixed with a biocompatible excipient to prepare into a dosage form of a tablet, a capsule, a microparticle, a spray, an emulsion or an injection, and is injected, smeared, orally. Or sprayed to the living body; as shown in FIG.
  • the high molecular polymer of the present invention forms a high molecular polymer composition 1 in which the high molecular polymer layer 11 is coated a shell layer 12 having a biocompatible excipient, and the shell layer 12 has a plurality of minute pores, so that toxins or irritants can enter the polymer composition 1 from the pores and are It is trapped in the slit formed by the interlacing of the high molecular polymer in the polymer layer 11, and is less likely to flow out of the pores of the outer shell layer 12 and come into contact with the living tissue to cause damage.
  • the present invention utilizes the rapid absorption of a polymer or a solution of a liquid or a solution of a harmful substance such as a toxin or an irritant (a new use of indirect adsorption of a toxic substance by directly adsorbing a liquid or a solution).
  • a harmful substance such as a toxin or an irritant
  • the adsorbed liquid is a common characteristic of most high molecular polymers, the absorption and discharge of harmful toxic substances contained in the indirect adsorbed liquid can be suppressed by utilizing the common characteristics of the polymer adsorbing liquid.
  • the R&D cost and practical application limits of the compound increase the adsorption capacity of each substance.
  • the present invention provides a new use of a high molecular polymer which can absorb body fluids present in a living body
  • the invention applies the characteristics of the polymer polymer capable of adsorbing liquid, and is applied to indirectly adsorbing and absorbing the body fluid (for example, digestive juice) existing in the living body or the liquid, the solution or the harmful toxic substances contained therein into the living body.
  • body fluid for example, digestive juice

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Description

高分子聚合物的用途及其组成物 技术领域
本发明关于高分子？合物的新用途及其组成物， 特别指将高分子？合物 溶液或其中所含的有害有毒物质经间接吸附、 吸收与排出的新用途及其组成 物。
背景技术
一般高分子纤维与聚合物， 例如天然生物高分子材料， 例如胶原蛋白、 明胶、 透明质酸、 几丁质和几丁聚醣及其衍生物等动物性来源高分子纤维与 聚合物， 或是褐藻酸盐与纤维素及其衍生物等植物性来源高分子纤维与聚合 物， 因为具有良好的生物相容性和生物可降解性， 且含有可水解的键结， 因 此通常可以在生物体内分解为小分子， 再经由肾脏过滤或代谢程序排出体 外。
这些高分子纤维与聚合物因为具有澎润的特性， 因此会被添加于食品以 帮助使用者在食用后产生饱足感， 而降低饮食量以达到轻体塑身的需求， 又 因为其具有大量纤维可以促进肠胃蠕动，因此经常被使用于作为软便剂（例如 Sterculia BP和 Frangula BPC)的成份， 以帮助具有排便困扰的患者得以顺利 排便。
然现今对于高分子纤维与聚合物的应用大多着重于其优异的吸水能力， 而忽略了其可能有其他的应用潜力， 因而降低了其实际应用价值。 发明内容
本发明的一目的在于提供高分子聚合物的新用途， 其可以吸收存在于生 物体中的体液（例如消化液）或进入生物体内的毒素或刺激性成份等有害物 质所存在的液体或溶液， 即藉由直接吸附液体或溶液而间接吸附毒性物质特 性的新用途， 减少体内的消化液并达到降低身体对食物消化吸收的效果， 并 且有助于将这些有害物质排出， 以保护生物体免于受到毒素或刺激性成份等 有害物质的伤害， 这些高分子聚合物因为具有良好的生物可相容性， 因此即 使被服用至生物体内， 也不会对生物体产生健康上的危害。
本发明将高分子聚合物能吸附液体的特性， 应用于将存在于生物体中的 体液（例如消化液）或进入生物体内的液体、 溶液或其中所含的有害有毒物 质经间接吸附、 吸收与排出的新用途及其组成物。 由于吸附液体为大多数高 分子聚合物的共同特性， 藉由利用高分子聚合物吸附液体的共同特性将间接 吸附液体其中所含的有害有毒物质吸收与排出， 能够减抑因高分子聚合物对 各个物质吸附能力不同而增加的研发成本与实际运用限制。
本发明所述的高分子聚合物包括了高分子纤维、 天然纤维、 人造纤维和 高分子吸收体等， 在较佳的情况下， 天然纤维指梧桐（Sterculia BP )或欧鼠 李（Frangula BPC )等， 在较佳的情况下， 天然纤维指胶原蛋白、 纤维素、 几丁质、 几丁聚醣， 这些天然纤维具有高度交错性的分子结构， 可以将酒类 中的乙醇 (alcohol), 咖啡因（caffeine), 茶素 (theine)、 尿酸 (uric acid), 脂质、 胆固醇、强酸强碱等对身体可能造成危害的物质所存在的液体或溶液 (利用直 接吸附液体或溶液而间接吸附毒性物质特性的新用途)加以吸附，并将的排出 生物体， 以降低生物体对于该等物质的吸收， 进一步减少该等物质对生体产 生的毒性作用、 副作用或是不良反应 (adverse effect)等， 以达到保护生物体器 官组织细胞的效果。
本发明的另一目的在于提供一种高分子聚合物的组成物， 其将此高分子 聚合物结合于至少一层具有生物可相容性的赋形剂之内， 例如为由此赋形剂 所形成的一外壳层， 且此具有生物可相容性的赋形剂外壳层上具有复数微小 孔洞， 因此当生物体吞服此高分子聚合物时， 此具有生物可相容性的赋形剂 可以保护此高分子聚合物不会受到生物体的体液或是酸碱值的破坏， 在一实 施例中， 此包覆有具有生物可相容性的赋形剂的高分子聚合物以咀嚼吞服的 方式进入生物体体内， 生物体内的有害物质便会由具有生物可相容性的赋形 剂的 d、孔进入而被高分子聚合物吸收， 高分子聚合物因为具有交错的形态， 而可以构成许多微小的孔隙， 因此可以将有害物质的分子固定在孔隙中， 藉 此减少和生物体组织产生接触的有害物质总量并避免这些有害物质对于生 物体的毒害。
由于吸附液体为大多数高分子聚合物的共同特性， 藉由利用高分子？合 物吸附液体的共同特性将间接吸附存在于生物体中的体液（例如消化液） ， 减少体内的消化液并达到降低身体对食物消化吸收的效果， 或是辅助将涉入 身体的液体其中所含的有害有毒物质吸收与排出， 能够减抑因高分子聚合物 对各个物质吸附能力不同而增加的研发成本与实际运用限制。
附图概述
图 1为本发明高分子聚合物组成物的剖面示意图。
【主要元件符号说明】
1高分子聚合物组成物
11高分子聚合物层
12外壳层
本发明的较佳实施方式
本发明提供高分子聚合物的新用途， 利用高分子聚合物来吸附存在于生 物体中的体液（例如消化液） ， 生物体内的毒素或刺激性成份等有害物质所 存在的液体或溶液 (藉由直接吸附液体或溶液而间接吸附毒性物质特性的新 用途)， 以达到减少体内的消化液并达到降低身体对食物消化吸收的效果，或 保护生物体组织免于和这些有害物质直接接触， 而导致这些有害物质被生物 体组织吸收并造成对健康危害的危险。 本发明将高分子聚合物能吸附液体的 特性， 应用于将体液， 存在或进入生物体内的液体、 溶液或其中所含的有害 有毒物质经间接吸附、 吸收与排出的新用途及其组成物。 由于吸附液体为大 多数高分子聚合物的共同特性， 藉由利用高分子聚合物吸附液体的共同特性 将间接吸附液体其中所含的有害有毒物质吸收与排出， 能够减抑因高分子聚 合物对各个物质吸附能力不同而增加的研发成本与实际运用限制。
本发明的高分子聚合物包括有高分子纤维、 天然纤维、 人造纤维和高分 子吸收体，其中天然纤维选自包括有下列成份的群组： Sterculia BP、 Frangula BPC、 胶原蛋白、 纤维素、 几丁质和几丁聚醣， 这些高分子聚合物都具有良 好的生物相容性特性， 并且具有网状脉络的分子结构， 其中并形成许多大小 不一的细缝， 因此当生物体服食这些高分子聚合物后， 并不会对身体产生危 害， 同时， 随着饮食而进入并存在于生物体内的毒素或刺激性成份等有害物 质都会被固定在高分子聚合物的细缝之间， 而不致于与生物体组织细胞产生 接触并对生物体造成细胞上的毒害。
实施例一
在本实施例中， 以 Sterculia BP为基材并以一般大众经常饮用的咖啡为 例， 说明本发明所述高分子聚合物的新用途， 其中 Sterculia BP—种高分子 纤维的高分子聚合物， 其可单独使用， 也可搭配其他具有吸附特性的高分子 材质使用， 本实施例将 Sterculia BP和 Frangula BPC以 25%和 75%的重量百 分比进行混合， 形成一高分子纤维混合物 (以下简称高分子纤维)， 将 1克的 此高分子纤维混合物于 30 毫升市售意式浓缩咖啡中混合均匀， 以形成高分 子纤维-咖啡混合物， 此一高分子纤维-咖啡混合物在经过 5分钟后已经开始 呈现粘稠的状态， 10分钟后，粘稠程度提升并转变为具有半固态的胶体状态， 随后， 高分子纤维-咖啡混合物的粘稠特性仍会继续提升， 至第 30分钟时， 高分子纤维 -咖啡混合物已经成为类似沙茶酱且几乎没有流动性的状态，由此 实施例可知，一旦使用者使用了此高分子纤维-咖啡混合物， 喝入体内的咖啡 因便会随着咖啡被吸附吸收在此高分子纤维-咖啡混合物中，而使得咖啡因和 人体细胞产生了阻隔的效果， 据此可以降低咖啡因对于人体的伤害。
如本实施例所述的高分子纤维 Sterculia BP和 Frangula BPC可以任意比 例搭配使用， 也可以个别单独使用， 或是搭配其他高分子聚合物进行使用。
实施例二
本实施例以一般大众经常饮用的可乐为例， 说明实施例一中的高分子纤 维 （ Sterculia BP和 Frangula BPC以 25%和 75%的重量百分比进行混合 )对 于吸收吸附可乐的功效， 本实施例将 1克的高分子纤维添加于 30毫升的可 乐中混合均匀， 以形成高分子纤维-可乐混合物， 此一高分子纤维-可乐混合 物在经过 5分钟后已经开始呈现粘稠的状态， 10分钟后， 粘稠程度提升且大 约有 95%的可乐都已经被高分子纤维与聚合物吸附吸收， 而几乎不再具有流 动性， 30 分钟时， 高分子纤维 -可乐混合物几乎完全成为固态的态样， 显见 此高分子纤维可以在短时间内迅速吸收留经的液体并将其吸收， 在吸收液体 的过程中， 亦会一并将液体中的有毒或有害物质吸附于其中， 因而达到保护 身体免于和这些有害物质接触并受到伤害的效果。
实施例三
本实施例说明实施例一中的高分子纤维对于吸收吸附酒精的效果， 其将 1克的高分子纤维混合物添加于 30毫升高粱酒（酒精含量 58% )中均匀搅拌 形成一高分子纤维-高粱酒混合物， 经过 5分钟后， 高分子纤维 -高粱混合物 开始产生粘稠度， 10 分钟后， 高分子纤维-高粱混合物呈现胶状的状态， 一 直到 20分钟和 30分钟时，高分子纤维-高粱混合物的型态开始为接近凝固状 的冻膏或膏状的态样， 最后在混合一小时后， 高分子纤维 -高粱混合物已经为 无法产生流动行为且接近固体状态的型态， 因此可见， 假若这些含有酒精等 有害物质的成份在进入的生物体后， 可以充分被高分子纤维与聚合物所吸 收， 并减少这些乙醇这类有害物质与人体细胞接触甚至产生毒害的机会。
若是将一克的 Sterculia BP添加于 50毫升的高粱酒中时， 高分子纤维
Sterculia BP 也会出现类似的吸附并逐渐使高分子高粱混合物呈现半流动或 是无法流动的膏状或是接近固态的型态。 高粱酒 （酒精含量 58% ) 中均匀搅 拌形成一高分子纤维-高粱酒混合物， 经过 5分钟后， 高分子纤维-高粱混合 物开始产生粘稠度， 10 分钟后， 高分子纤维-高粱混合物呈现胶状的状态， 一直到 20分钟和 30分钟时，高分子纤维-高粱混合物的型态开始为接近凝固 状的冻膏或膏状的态样， 最后在混合一小时后， 高分子纤维-高粱混合物已经 为无法产生流动行为且接近固体状态的型态， 因此可见， 假若这些含有酒精 等有害物质的成份在进入的生物体后， 可以充分被高分子纤维与聚合物所吸 收， 并减少这些乙醇这类有害物质与人体细胞接触甚至产生毒害的机会。
本发明的高分子聚合物可制做为可咀嚼的剂型， 消费者可以利用咀嚼服 食的方式进行服用， 尤其是对于那些经常必须喝酒或应酬的消费者来说， 在 喝酒或是应酬前若是能先服用这些高分子聚合物， 一旦开始饮酒之后， 停留 在消化道的高分子聚合物便会开始吸附酒品中的乙醇， 如此， 便不会有太多 的乙醇透过消化道壁的细胞被人体所吸收， 也因此不会承受太多乙醇对身体 的毒害， 相同的方式也可以应用于对于药物或对咖啡因、 茶素等刺激性成份 具有依赖性的病患身上； 更甚者， 本发明的高分子聚合物更可以使用于酸、 碱性物质的吸收， 例如误食强酸、 强碱或是胃酸分泌过多的情况下， 使用本 发明的高分子聚合物可以将这些酸碱液体进行吸收， 一方面可以避免强性 酸、 碱对于组织细胞造成的伤害， 另一方面则可以迅速舒緩身体因为酸、 碱 物质而产生的不适。
本发明的高分子聚合物可以与一具有生物可相容性的赋形剂进行混合， 而制备成为锭剂、 胶嚢、 微粒、 喷剂、 乳剂或针剂等剂型， 并以注射、 涂抹、 口服或喷洒的方式施用于生物体； 请参考图 1所示， 在本实施例中， 本发明 的高分子聚合物形成一高分子聚合物组成物 1 ,其中高分子聚合物层 11被包 覆在一具有生物可容性赋形剂的外壳层 12内， 此外壳层 12上具有复数微小 的孔洞， 因此毒素或是刺激性可以由该等孔洞进入此高分子聚合物组成物 1 中， 并且被卡合在高分子聚合物层 11 中高分子聚合物交错所形成的细缝之 内， 而不易再由外壳层 12的孔洞流出并与生物体组织接触并造成破坏。
综上所述， 本发明利用高分子聚合物对于毒素或是刺激性等有害物质所 存在的液体或溶液 (藉由直接吸附液体或溶液而间接吸附毒性物质特性的新 用途)的快速吸收， 来遏止该些有害物质与生物体身体组织接触的机会， 来达 到降低这些有害物质的毒性作用、 减少对生物体产生的副作用以及不良作用 的效果。 由于吸附液体为大多数高分子聚合物的共同特性， 藉由利用高分子 聚合物吸附液体的共同特性将间接吸附液体其中所含的有害有毒物质吸收 与排出， 能够减抑因高分子？合物对各个物质吸附能力不同而增加的研发成 本与实际运用限制。
工业实用性
本发明提供高分子聚合物的新用途， 其可以吸收存在于生物体中的体液
(例如消化液）或进入生物体内的毒素或刺激性成份等有害物质所存在的液 体或溶液， 即藉由直接吸附液体或溶液而间接吸附毒性物质特性的新用途， 减少体内的消化液并达到降低身体对食物消化吸收的效果， 并且有助于将这 些有害物质排出， 以保护生物体免于受到毒素或刺激性成份等有害物质的伤 害， 这些高分子聚合物因为具有良好的生物可相容性， 因此即使被服用至生 物体内， 也不会对生物体产生健康上的危害。 本发明将高分子聚合物能吸附 液体的特性， 应用于将存在于生物体中的体液（例如消化液）或进入生物体 内的液体、 溶液或其中所含的有害有毒物质经间接吸附、 吸收与排出的新用 途及其组成物。 由于吸附液体为大多数高分子聚合物的共同特性， 藉由利用 高分子聚合物吸附液体的共同特性将间接吸附液体其中所含的有害有毒物 质吸收与排出， 能够减抑因高分子聚合物对各个物质吸附能力不同而增加的 研发成本与实际运用限制。

Claims

权 利 要 求 书
1、 一种高分子聚合物的新用途， 利用此高分子聚合物吸收液体或溶液 的途径进入生物体内的毒素或刺激性成份等有害物质， 并且将这些有害物质 排出， 以保护生物体免于受到毒素或刺激性成份的伤害。
2、 如权利要求 1 所述的新用途， 其中该高分子聚合物包括有高分子纤 维、 天然纤维、 人造纤维和高分子吸收体。
3、 如权利要求 2所述的新用途， 其中该天然纤维包括有梧桐、 欧鼠李、 胶原蛋白、 纤维素、 几丁质和几丁聚醣。
4、 如权利要求 1至 3 中任一项所述的新用途， 其中该高分子聚合物以 注射、 涂抹、 口月良或喷洒的方式施用。
5、 如权利要求 4所述的新用途， 其中该高分子聚合物吸收酸液、 乙醇、 咖啡因、 碱液、 茶素或尿酸。
6、 一种高分子聚合物组成物， 其将一高分子聚合物结合于一生物可相 容的赋形剂， 以利用该高分子聚合物吸收进入生物体内的毒素或刺激性成份 等有害物质， 并且将这些有害物质排出， 以保护生物体免于受到毒素或刺激 性成份的伤害。
7、 如权利要求 6所述的高分子聚合物组成物， 其中该高分子聚合物包 括有高分子纤维、 天然纤维、 人造纤维和高分子吸收体。
8、 如权利要求 7 所述的高分子聚合物组成物， 其中该天然纤维包括有 梧桐、 欧鼠李、 胶原蛋白、 纤维素、 几丁质和几丁聚醣。
9、 如权利要求 6至 8中任一项所述的高分子聚合物组成物， 其中该高 分子聚合物以注射、 涂抹、 口服或喷洒的方式施用。
10、 如权利要求 9所述的高分子聚合物组成物， 其中该高分子聚合物吸 收酸液、 乙醇、 咖啡因、 碱液、 茶素或尿酸。
PCT/CN2012/071184 2011-02-16 2012-02-16 高分子聚合物的用途及其组成物 WO2012109991A1 (zh)

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RU2587718C2 (ru) 2016-06-20
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US10695388B2 (en) 2020-06-30
CN102641496A (zh) 2012-08-22
CO6801797A2 (es) 2013-11-29
AU2012217543A1 (en) 2013-10-03
HUE048333T2 (hu) 2020-07-28
BR112013020599A2 (pt) 2017-10-31
SG193235A1 (en) 2013-10-30
CN103402378A (zh) 2013-11-20
EP2676555A4 (en) 2017-05-24
PT2676555T (pt) 2020-03-27
RU2013142189A (ru) 2015-03-27
ES2776637T3 (es) 2020-07-31
DOP2013000187A (es) 2014-01-31
EP2676555B1 (en) 2019-12-25
MX349794B (es) 2017-08-14
MX2013009394A (es) 2013-08-29
CA2827510A1 (en) 2012-08-23
AU2012217543B2 (en) 2016-04-28
BR112013020599B1 (pt) 2019-10-15
CR20130463A (es) 2013-10-23
JP5991994B2 (ja) 2016-09-14
PL2676555T3 (pl) 2020-06-29
MY166779A (en) 2018-07-23
NZ614587A (en) 2015-10-30
CA2827510C (en) 2017-10-17
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US20130280292A1 (en) 2013-10-24
CL2013002360A1 (es) 2014-03-28
JP2014506885A (ja) 2014-03-20
KR20140006025A (ko) 2014-01-15
DK2676555T3 (da) 2020-02-24
EP2676555A1 (en) 2013-12-25

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