NZ614587B2 - Use for high-molecular-weight polymer and composition including same - Google Patents
Use for high-molecular-weight polymer and composition including same Download PDFInfo
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- NZ614587B2 NZ614587B2 NZ614587A NZ61458712A NZ614587B2 NZ 614587 B2 NZ614587 B2 NZ 614587B2 NZ 614587 A NZ614587 A NZ 614587A NZ 61458712 A NZ61458712 A NZ 61458712A NZ 614587 B2 NZ614587 B2 NZ 614587B2
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- New Zealand
- Prior art keywords
- molecular weight
- high molecular
- weight polymer
- organism
- liquid
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Links
- 239000000203 mixture Substances 0.000 title claims abstract description 57
- 229920006158 high molecular weight polymer Polymers 0.000 title claims description 55
- 239000000126 substance Substances 0.000 claims abstract description 36
- 239000007788 liquid Substances 0.000 claims abstract description 32
- 238000010521 absorption reaction Methods 0.000 claims abstract description 23
- 239000003053 toxin Substances 0.000 claims abstract description 20
- 231100000765 toxin Toxicity 0.000 claims abstract description 20
- 241000934878 Sterculia Species 0.000 claims abstract description 16
- 235000021282 Sterculia Nutrition 0.000 claims abstract description 16
- 229940059107 sterculia Drugs 0.000 claims abstract description 16
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 13
- 241001528248 Frangula Species 0.000 claims abstract description 12
- 229920002101 Chitin Polymers 0.000 claims abstract description 8
- 239000000243 solution Substances 0.000 claims description 23
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 8
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims description 7
- 229960001948 caffeine Drugs 0.000 claims description 7
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims description 7
- 238000001179 sorption measurement Methods 0.000 claims description 6
- 230000029142 excretion Effects 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000000084 colloidal system Substances 0.000 claims description 4
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims description 3
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 229940116269 uric acid Drugs 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims 2
- 239000000835 fiber Substances 0.000 description 27
- 108700012359 toxins Proteins 0.000 description 14
- 210000001124 body fluid Anatomy 0.000 description 10
- 239000010839 body fluid Substances 0.000 description 10
- 230000006378 damage Effects 0.000 description 9
- 230000001079 digestive effect Effects 0.000 description 9
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 9
- 231100000614 poison Toxicity 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 7
- 230000004936 stimulating effect Effects 0.000 description 7
- 239000003440 toxic substance Substances 0.000 description 7
- 235000013353 coffee beverage Nutrition 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000029087 digestion Effects 0.000 description 4
- 230000035622 drinking Effects 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 235000020066 kaoliang wine Nutrition 0.000 description 4
- 229920001661 Chitosan Polymers 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 235000015114 espresso Nutrition 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 239000006187 pill Substances 0.000 description 3
- 239000006096 absorbing agent Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012209 synthetic fiber Substances 0.000 description 2
- 229920002994 synthetic fiber Polymers 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000000274 adsorptive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 235000020930 dietary requirements Nutrition 0.000 description 1
- 239000008144 emollient laxative Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
- A23L33/24—Cellulose or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
- A23L33/28—Substances of animal origin, e.g. gelatin or collagen
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/332—Promoters of weight control and weight loss
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/50—Polysaccharides, gums
- A23V2250/51—Polysaccharide
- A23V2250/5116—Other non-digestible fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Abstract
Disclosed is a composition comprising a high-molecular weight polymeric core; and a shell disposed outside of the high-molecular weight polymeric core comprising a biocompatible excipient; wherein the high molecular weight polymeric core is Sterculia BP, Frangula BP, or chitin. Also disclosed is the use of the composition for the absorption of a toxin or a harmful substance in a liquid or solution intaked into an organism the use of the composition for the absorption of a toxin or a harmful substance in a liquid or solution intaked into an organism
Description
USE FOR HIGH-MOLECULAR-WEIGHT POLYMER AND COMPOSITION INCLUDING
SAME
FIELD OF THE INVENTION
The present invention relates to a use of a high molecular weight polymer and a
composition thereof; especially the invention relates to a use which applies a high molecular
weight polymer in indirectly adsorbing or absorbing harmful or toxic substances existed or
contained in body fluid or solution so that they can be removed, and a composition containing a
high molecular weight polymer.
BACKGROUND OF THE INVENTION
A conventional high molecular weight polymer includes, for example, a natural
biomedical polymeric material (such as a high molecular weight fiber or a polymer which is
originated from animal including a collagen, a gelatin, a hyaluronic acid, a chitin, a chitosan and
a derivative thereof and a high molecular weight fiber or polymer which is originated from plant
including an alginates, a cellulose and a derivative thereof. Since it has excellent
biocompatibility and bio-degradability and contains hydrolysable bonding, it can be degraded to
small molecules in an organism, and is removed out of the body through a kidney filtering and
metabolizing.
Those high molecular weight fibers and polymers might be used as a food additive due to
well swelling property, so they can generate full sense after eating, and decrease dietary
requirement to achieve the purpose of slimming. Moreover, the high molecular weight polymers
comprise a lot of fiber so that they can improve the movement of the gastrointestinal tract and be
used as a stool softener (such as Sterculia BP or Frangula BPC) to promote the defecation of a
constipated patient.
However, the above mentioned applications of the high molecular weight fibers and
polymers focus on their superior water adsorbability but other potential applications are ignored.
Therefore, their actually industrial values are decreased.
OBJECT
[0004A] It is an object of the present invention to provide a composition and/or the use of a
composition in the manufacture of a medicament for the absorption or adsorption of a toxin or
harmful substance in a liquid or solution intaked into an organism, or to at least provide the
public with a useful choice.
DESCRIPTIONS OF THE INVENTION
In one aspect the present invention provides a use of a high molecular weight polymer
in the absorption of body fluid (such as digestive juice) in an organism or of a liquid or solution
to be intaked into an organism containing a toxin or harmful substance. That is, the use relates
to direct absorption of a liquid or solution to indirectly adsorb the toxin or harmful substance
therein, decrease of digestive juice in an organism, decrease of digestion and absorption of food
in an organism and improvement of excretion of these harmful substances to prevent the
organism from being damaged by the toxin or the harmful substance. These high molecular
weight polymers have good biocompatibility, so they will not harm the health of an organism
after being intaked into it.
The invention applies a high molecular weight polymer to a body fluid (such as
digestive juice) in an organism or a liquid or a solution to be intaked into an organism so that
harmful or toxic substances contained therein can be removed through indirect adsorption or
absorption and excretion. Since most high molecular weight polymers have a common feature
in adsorbing liquid, they can indirectly absorb the harmful or toxic substances in the liquid.
Therefore, the application field of the high-molecular weight polymer is wider and the polymer
has an improved commercial potential.
The high-molecular weight polymer of the invention includes: a high-molecular
weight fiber, a natural fiber, a synthetic fiber, and a high molecular weight absorber. Preferably,
the natural fiber is Sterculia BP or Frangula BPC. Preferably, the natural fiber is collagen,
cellulose, chitin and chitosan. These natural fibers have high cross-linking molecular structure,
so they can absorb alcohol in wine and a liquid or solution that may have harmful substance
(such as caffeine, theine, uric acid, lipid, cholesterol, strong acid and strong base) by utilizing
the feature of directly absorption of the liquid or solution to indirect adsorb toxic substances,
and then they are excreted from the body to reduce absorption of such substances by the body,
so the toxicity, side effect and adverse effect caused by such substances can be further reduced
to achieve the effect of protecting organ, tissue and cells of an organism.
[0007A] In another aspect the present invention provides the use of a composition in the
manufacture of a medicament for the absorption of a toxin or a harmful substance in a liquid
or solution intaked into an organism, wherein the composition comprises:
a high molecular weight polymeric core comprising a high molecular weight polymer
wherein the high molecular weight polymer is Sterculia BP, Frangula BPC, or chitin;
a shell disposed outside of the high molecular weight polymeric core comprising a
biocompatible excipient; and wherein
the high molecular weight polymer is present in the medicament in an amount
sufficient to convert the intaked liquid or solution to a semi-solid to solid colloid.
In another aspect the present invention provides a composition comprising a high
molecular weight polymer, wherein the high molecular weight polymer is combined with a
layer of biocompatible excipient, for example, an outer shell formed by the excipient, which has
a plurality of micropores. When the high molecular weight polymer is taken by an organism,
the biocompatible excipient can prevent the high molecular weight polymer from damage by a
body fluid of the organism, an acid or a base. In one embodiment, after the high molecular
weight polymer coated with the biocompatible excipient is orally administered to an organism,
harmful substances in the organism enter into the composition through the micropores of the
biocompatible excipient and then absorbed by the high molecular weight polymer. Since the
high molecular weight polymer has a cross-linking structure, so micropores can be constituted.
Thus, harmful substances can be fixed in the micropores to reduce contact of the substances
with tissues of the organism and prevent the organism from damage by these harmful
substances.
Since absorption of a liquid is a common feature of most high molecular weight
polymers, they can absorb body fluid (such as digestive juice) in an organism to decrease the
digestive juice in body and thus reduce digestion and absorption of a food. Alternatively,
they can assist to adsorb harmful substances contained in body fluid of a body and remove the
harmful substances. Therefore, the application filed of the high-molecular weight polymer is
wider and the polymer has an improved commercial potential.
[0009A] In a further aspect the present invention provides a composition comprising:
a high-molecular weight polymeric core; and
a shell disposed outside of the high molecular weight polymeric core comprising a
biocompatible excipient;
wherein the high molecular weight polymeric core is Sterculia BP, Frangula BPC, or
chitin.
[0009B] In another aspect the present invention provides the use of the composition of the
preceding paragraph in the manufacture of a medicament for the adsorption of a toxin or a
harmful substance in a liquid or solution intaked into an organism.
BRIEF DESCRIPTION OF THE DRAWINGS
Fig. 1 is a cross- sectional view of a composition comprising a high molecular
weight polymer in accordance with the present invention.
DESCRIPTIONS OF THE SYMBOLS OF THE ELEMENTS
1 Composition comprising a high molecular weight polymer
11 Layer of high molecular weight polymer
12 Layer of outer shell
PREFERRED EMBODIMENTS OF THE INVENTION
The invention provides a use of a high molecular weight polymer, which utilizes a high
molecular weight polymer to adsorb a body fluid (such as digestive juice) or a liquid or solution
in an organism containing toxins or stimulating components (by directly absorb the liquid or
solution to indirectly adsorb toxic substances) to decrease body fluid in a body, reduce digestion
and absorption of food by a body or prevent tissues of an organism from direct contact of these
harmful substances, absorption of the harmful substances and hazard to health. Since absorption
of a liquid is a common feature of most high molecular weight polymers, by utilizing the
common feature of the high molecular weight polymer in absorbing a liquid, the harmful
substances contained in the liquid can be indirectly adsorb and then excreted. Therefore, the
application field of the high-molecular weight polymeric composition is wider and the polymer
has an improved commercial potential.
The high-molecular weight polymer of the invention includes: a high-molecular weight
fiber, a natural fiber, a synthetic fiber, and a high molecular weight absorber. Preferably, the
natural fiber is selected from the group consisting of: Sterculia BP, Frangula BPC, collagen,
cellulose, chitin and chitosan. These natural fibers have good biocompatible and network
molecular structure with slits in various sizes. Therefore, after the high molecular weight
polymer coated with the biocompatible excipient is taken by an organism, no hazard can be
caused. In addition, harmful substances can be fixed in the slits of the high molecular weight
polymer to prevent the organism from contact with the harmful substances and hazard by these
harmful substances.
Example 1
In this example, Sterculia BP is selected to adsorb a coffee solution to illustrate the new
use of the high molecular weight polymer of the present invention. The Sterculia BP is a kind of
high molecular fiber, which can be applied single or mixed with another adsorptive polymer
material. In this example, 25% by weight of Sterculia BP is mixed with 75% by weight of
Frangula BPC to from a high molecular weight fiber mixture (hereafter referred to as "high
molecular weight fiber"). One gram of the high molecular weight fiber mixture is added into 30
ml espresso coffee and then mixed well to form a fiber-coffee mixture. After 5 minutes, the
fiber-coffee mixture exhibited sticky. After 10 minutes, the fiber-coffee mixture coverts to a
semi-solid colloid and was continuously getting sticky. After 30 minutes, the fiber-coffee
mixture was almost solidified and lost fluidity. It can be known from this example that when a
person intaked the fiber mixture before drinking the espresso coffee, the caffeine in the coffee
can be adsorbed by the fiber-coffee mixture through the adsorption of espresso coffee. Therefore,
most caffeine is isolated from the cells of human body so that the damage to health resulting
from the caffeine can be reduced.
The Sterculia BP and Frangula BPC can be mixed with any ratio. The Sterculia BP and
Frangula BPC can be used individually or be mixed with any other high molecular weight
polymer.
Example 2
A cola that is commonly consumed by general public was used as an example to illustrate
the new use of the high molecular weight fiber of the present invention. The 25% by weight of
Sterculia BP is mixed with 75% by weight of Frangula BPC to from a high molecular weight
fiber mixture. One gram of fiber mixture is added into 30 ml cola then mixed well to form a high
molecular fiber-cola mixture. After 5 minutes, the high molecular fiber-coffee mixture exhibited
sticky. After 10 minutes, the viscosity of the fiber-cola mixture increased and around 95% cola
was absorbed by the fiber-cola mixture and lost fluidity. After 30 minutes, the fiber-cola mixture
was almost solidified. Obviously, the high molecular weight fiber can rapidly absorb the liquid in
a short time. During the absorption, toxic or harmful substances can be adsorbed by the fiber
accordingly to achieve the effect of preventing body from contact with and damage by these
harmful substances.
Example 3
This example illustrates the effect of absorbing alcohol by the high molecular weight
polymer of Example 1. One gram high molecular weight polymer mixture was added into 30
ml sorghum wine containing 58% alcohol to form a high molecular weight fiber- sorghum wine
mixture. The high molecular weight fiber-wine mixture exhibited stringy after 5 minutes mixing.
After 10 minutes, the high molecular weight fiber-wine mixture showed gel exhibition. After
~30 minutes, the high molecular weight fiber-wine mixture showed paste exhibition. After one
hour, the high molecular weight fiber-wine mixture lost fluidity and became solid state.
Accordingly, the high-molecular weight polymer of the present invention has capability to
adsorb the intaked alcohol and prevent the alcohol from directly contacting the tissue and
generating health damage.
One gram Sterculia BP was added to 50 ml sorghum wine and Sterculia BP exhibited
absorption similar to the above fiber and the high molecular weight fiber-sorghum wine mixture
gradually exhibited semi-fluidity state or non-fluid paste or solid state. The high molecular
weight fiber was mixed with sorghum wine containing 58% alcohol and then stirred to form a
high molecular weight fiber-wine mixture. After 5 minutes, the high molecular weight fiber-
wine mixture exhibited sticky. After 10 minutes, the high molecular weight fiber-wine mixture
showed gel exhibition. After 20~30 minutes, the high molecular weight fiber-wine mixture
showed paste exhibition. After one hour, the high molecular weight fiber-wine mixture lost
fluidity and became solid state. Accordingly, the high-molecular weight polymer of the present
invention has capability to adsorb the intaked alcohol and prevent the alcohol from directly
contacting the tissue and generating health damage.
The high molecular weight polymer can be produced in a chewable form and consumers
can be administered by chewing; especially for those consumers who need to drink wine
frequently. If the high molecular weight polymer is intaked before drinking, upon drinking, the
high molecular weight polymer stayed in gastrointestinal tract can absorb alcohol in the wine so
that not too much alcohol is absorbed by body through cells in the gastrointestinal tract and the
body will not be harmed by alcohol. The high molecular weight polymer also can be applied in
patients dependent on stimulating components such as caffeine and theine. The high molecular
weight polymer of the invention can be applied in absorption of acidic or basic material. For
example, in case of drinking strong acid or base by mistake or excess secret of gastric juice, the
high molecular weight polymer can absorb the strong acid or base to prevent tissues and cells
from hazard by the strong acid or base to alleviate the uncomfortableness caused by the strong
acid or base.
The high-molecular weight polymeric composition in this embodiment is mixed with a
biocompatibility excipient to form a pill, a tablet, a capsule, a micro particle, a emulsion or
an injection that are injected, spread, oral administrated or sprayed to the body. With reference to
Fig. 1, high-molecular weight polymeric composition of the embodiment is manufactured as a
pill 1 and comprises a high-molecular weight polymeric core 11 and a shell 12. The shell 12 is
disposed outside of the high-molecular weight polymeric core 11 and is made of at least one
biocompability biocompatibility excipient and comprises multiple holes. The toxin or the
harmful substance gets into the pill and is fixed between fibers of high-molecular weight
polymeric core 11 within the high-molecular weight polymeric core 11 and is blocked to move
out from the hole of the shell 12 to contact with the tissues.
Accordingly, the high-molecular weight polymeric composition promptly receives and
adsorbs the toxin or stimulating substance existed in the liquid or solution to avoid the harmful
toxin or stimulating substance from directly contacting to the tissue to reduce the toxicity,
damage degree and side affection. The new use of the high-molecular weight polymeric
composition is to directly adsorb the intaked solution or liquid to indirectly garb the harmful
substance and toxin existed in the solution or liquid that is removed out of the body with the
high-molecular weight polymeric composition. Therefore, the application field of the high-
molecular weight polymeric composition is wider to improve the commercial potential.
INDUSTRIAL APPLICABILITY
The invention provides a use of a high molecular weight polymer in the absorption of
body fluid (such as digestive juice) in an organism or a liquid or solution to be intaked into an
organism containing a toxin or a stimulating component. That is, the use relates to direct
absorption of a liquid or solution to indirectly adsorb the toxins or stimulating components
existed therein, decrease of digestive juice in body, decrease of digestion and
absorption of food in a body and improvement of excretion of these harmful substances to
prevent the body from being damaged by the toxin or the stimulating substance. These high
molecular weight polymers have good biocompatibility, so they will not harm health of an
organism after being intaked into it. The invention applies a high molecular weight polymer to a
body fluid (such as digestive juice) in an organism or a liquid or a solution to be intaked into an
organism so that harmful or toxic substances contained therein can be removed through indirect
adsorption or absorption and excretion. Since most high molecular weight polymers have a
common feature in adsorbing liquid, they can indirectly absorb the harmful or toxic substances in
the liquid. Therefore, the application field of the high-molecular weight polymeric composition
is wider to improve the commercial potential.
Unless the context clearly requires otherwise, throughout the description and the claims,
the words “comprise”, comprising”, and the like, are to be construed in an inclusive sense as
opposed to an exclusive or exhaustive sense, that is to say, in the sense of “including, but not
limited to”.
The reference to any prior art in the specification is not, and should not be taken as, an
acknowledgement or any form of suggestion that the prior art forms part of the common general
knowledge in New Zealand.
Claims (12)
1. The use of a composition in the manufacture of a medicament for the absorption of a toxin or a harmful substance in a liquid or solution intaked into an organism, wherein the composition comprises: a high-molecular weight polymeric core comprising a high molecular weight polymer wherein the high molecular weight polymer is Sterculia BP, Frangula BPC, or chitin, a shell disposed outside of the high molecular weight polymeric core comprising a biocompatible excipient; and wherein the high molecular weight polymer is present in the medicament in an amount sufficient to convert the intaked liquid or solution to a semi-solid to solid colloid.
2. The use of Claim 1, wherein the medicament is formulated to be administered by injection, daub, oral administration or spraying.
3. The use of Claim 1 or Claim 2, wherein the toxin or harmful substance is acid, alcohol, caffeine, base, theine or uric acid.
4. The use of any one of Claims 1 to 3, wherein 1g of the high molecular weight polymer is used to absorb 30 ml to 50 ml of the liquid or solution.
5. The use of any one of Claims 1 to 4, wherein the colloid formed is removed from the organism by excretion.
6. A composition comprising: a high-molecular weight polymeric core; and a shell disposed outside of the high-molecular weight polymeric core comprising a biocompatible excipient; wherein the high molecular weight polymeric core is Sterculia BP, Frangula BP, or chitin.
7. The use of the composition of Claim 6 in the manufacture of a medicament for the adsorption of a toxin or a harmful substance in a liquid or solution intaked into an organism.
8. The use of Claim 7, wherein the medicament is formulated to be administered by injection, daub, oral administration or spraying.
9. The use of Claim 7 or Claim 8, wherein the toxin or harmful substance is acid, alcohol, caffeine, base, theine or uric acid.
10. The use as claimed in Claim 1, substantially as hereinbefore described with particular reference to any one of more of the examples and/or figure 1.
11. A composition as claimed in Claim 6, substantially as hereinbefore described with particular reference to any one or more of the examples and/or figure 1.
12. The use as claimed in Claim 7, substantially as hereinbefore described with particular reference to any one or more of the examples and/or figure 1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100392786A CN102641496A (en) | 2011-02-16 | 2011-02-16 | New application and composition of high-molecular polymer |
| CN201110039278.6 | 2011-02-16 | ||
| PCT/CN2012/071184 WO2012109991A1 (en) | 2011-02-16 | 2012-02-16 | Use for high-molecular-weight polymer and composition including same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NZ614587A NZ614587A (en) | 2015-10-30 |
| NZ614587B2 true NZ614587B2 (en) | 2016-02-02 |
Family
ID=
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