JP2007000125A - Method for producing modified activated carbon and application method as health food - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide safely ingestible charcoal for medicine or food through modifying a charcoal surface in view of the fact that internal ingestion of activated carbon as Japanese official preparation from old times is avoided because of side effect such as constipation. <P>SOLUTION: A method for producing the modified activated carbon comprises mixing and sticking polyhydric alcohol (glycerin or the like) or its aqueous solution with/to activated carbon dust. Alternatively, the method comprises mixing, wrapping and processing cyclodextrin aqueous solution with carbon dust, and as the case may be, mixing, wrapping, processing and modifying the three materials of active carbon dust, polyhydric alcohol or solution such as its water and cyclodextrin aqueous solution, in the same manner as the above. A proper quantity of ethanol is, if necessary, added in the process so as to adjust a sticking quantity of polyhydric alcohol to charcoal holes, and disinfect and stabilize. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a modified production method of medicinal or edible activated carbon, application as a health food, and a processing method.

Traditionally, charcoal has not been widely used for food in humans, and it has been reported that some people are using it for health, and when monkeys and kangaroos become sick, they instinctively eat and recover charcoal. Recently, it has been aired on television and is becoming a hot topic.
On the other hand, in Japan, it has been instructed by the Japanese Pharmacopoeia as medicinal charcoal, and it has been used rarely as an emergency in the event of accidents caused by food poisoning or toxic ingestion. As an adjunct in dialysis treatment for patients with chronic nephritis, considerable efficacy is recognized and useful.
Traditionally, medicinal charcoal has an active and useful physical property possessed by its own porous adsorption hole and a halobase having a halogen genus present on the surface of the charcoal molecule, and various good beneficial bacteria present in each charcoal hole. A favorable beneficial pharmacological action has been observed.
Toxic substances that enter the body, such as dioxins, environmental hormones, and food additive components, are contained in bile by the liver circulation and discharged into the duodenum, so activated carbon adsorbs these harmful substances and adsorbs harmful substances. Charcoal is excreted outside the body together with feces, and most bile components are again absorbed and recovered from the small intestine into the body.
Therefore, if you continue to consume activated carbon, you can expect significant health benefits.
In addition, black charcoal generates far-infrared rays and negative ions in the human body, and recently, the great health effects of charcoal have been recognized with high appreciation by the world.
However, taking charcoal usually leads to constipation, sometimes even the risk of intestinal obstruction, and there are generally few people who still consume charcoal.

The demerits of the charcoal, such as constipation, are due to the surface of the charcoal molecules being jagged, with a lot of fine corners and a large adsorbing force and porous contact surface. It seems that it is caused by the fact that the adhesiveness is large, and it is necessary to modify the surface state of the carbon molecules that cause these.
That is, it is necessary to modify the carbonic acid molecules so that they do not stick to the wall of the intestine and are easy to flow through the large intestine toward the rectum.
In order to ingest the activated carbon without side effects as described above, it is conceivable to coat the activated carbon itself with an enteric film, but in such a case, adsorption of toxins in the bile, far-infrared effect, negative ion effect, etc. There is also a concern that the coating will not fully function and the coating may interfere with the effectiveness of the carbon molecules to some extent.
Also, during the entire process of passing through the digestive tract, due to considerable peristaltic motion and solubility in high-temperature water, there is a concern that the coating film may be damaged and contact between activated carbon and toxin may be reduced. It is done.
The present invention has been devised in view of the above problems and prevents side effects such as constipation due to adverse effects such as sticking to the intestinal inner wall even if activated carbon is ingested for a long period of time. An object of the present invention is to provide a method for producing a modified activated carbon which can exhibit the maximum effect without reducing the negative ion effect.

もし、混合しにくい場合、乳化剤等を使いエマルジョン化して加工すればよい。
又其他の加工法として、多価アルコールも、エタノールをも使用せずα、又はβ、又はγのサイクロデキストリン（環状オリゴ糖）３００グラムを水・約１７０ｍｌに溶解させた溶液を活性炭末１００グラムとを混合攪拌、３０〜１２０分程度包接反応させ、凍結乾燥法等で乾燥加工する方法でもよい。
勿論、サイクロデキストリン水溶液、多価アルコール（グリセリン等）又は水等の溶液両者を併用し、炭末に多価アルコール（グリセリン等）を吸着させサイクロデキストリン水溶液とも混合包接加工するのもよい。
勿論このとき多価アルコール及びサイクロデキストリン及び活性炭末を同時に混合加工してもよい。
又活性炭に油溶性物質（ビタミンＥ又はＡ、又は油類等）を十分混合せしめ、吸着せしめ、α、又はβ、又はγ、等のサイクロデキストリン（環状オリゴ糖）の水溶液と混合攪拌し包接反応せしめてなる改質性炭の製造加工法もよい。
このようにして得られた改質活性炭は、濾過、必要あれば水、其の他の溶媒により洗滌、乾燥して、あるいはそのまま薬用炭、又は食用炭として利用することができる。
又、適当な担体又は賦形剤で希釈して、任意に適当な添加剤（例えば矯味剤、結合剤、崩壊剤、界面活性剤）を添加して医薬品又は食品の製造分野において公知の方法によって、医薬品又は健康食品として、散剤、細粒剤、顆粒剤、錠剤、丸剤、軟カプセル剤、硬カプセル剤、ビース剤、マイクロカプセル剤等、又は活性炭をそのまま糖衣シェラック加工等したもの、これらの浮遊懸濁液等の数々の形態で使用することができる。
なお、ここでの健康食品とは、通常の食品よりも積極的な意味で、人又は動物の保健、健康維持、増進等の目的として摂取する食品を意味する。
さらにこれらの活性炭は食品に添加することにより、健康食品として利用することができる。
例えば、液体、又は半固形、固形の製品、具体的には、クッキー、せんべい、ゼリー、ようかん、ヨーグルト、まんじゅう、シュークリーム、アイスクリーム、等の菓子類、清料飲料、栄養飲料、ビール等の飲み物、味噌、醤油（ショウユ）、ソース等の調味料、ソバ、ウドン、パスタ、中華めん（ラーメン）等のメン類、悪臭のある納豆、クサヤ等の食物。
又、ベットフードやビーフジャーキー等の動物用の食品であってもよい。
あるいは最終製品に上記活性炭を混合、又は塗布、噴霧などして添加して、健康食品としてもよいし、これらの食品を食する際に、活性炭の粉末等をふりかけて、一緒に食してもよい。
次に本案、改質活性炭末を配合し、従来品に比し、機能性や香味を著しく改善される新規性のある健康食品的な加工法の例を述べる。The following examples of the adsorption reaction processing method can be performed under normal pressure or under pressure, but under the pressure, the adsorption reaction is faster and more efficient and smooth.
About 100% to 10% of polyhydric alcohol (in which glycerin seems to be suitable), that is, as it is or as a solution (generally an aqueous solution or an ethanol aqueous solution. For example, 100% When blending glycerin, add about 1 to 5 g, mix and stir well (about 20 to 90 minutes), and adsorb and entrapped in the porous carbon molecular holes.
In this case, whether the glycerin aqueous solution is used or not, the result of our comparative test shows that the adsorption rate of glycerin was the best. Sterilizing power can be expected for each material, and it is preferable for product stability by preventing alteration for commercialization.
Also noteworthy is that, according to my experimental results, the adsorption hole of the above charcoal powder is polyhydric alcohol, and the adsorption amount of glycerin used mainly in it is inversely proportional to the concentration of ethanol solution at this time. found.
That is, when it is desired to reduce the amount of glycerin adsorbed, the ethanol concentration can be increased.
Furthermore, in the above-mentioned activated carbon modification processing method, an aqueous solution obtained by dissolving 300 g as an appropriate amount of cyclodextrin (cyclic oligosaccharide) such as α, β, γ, etc. As before, 100 grams of activated carbon powder (granule) and glycerin (or polyhydric alcohol), glycerin (or polyhydric alcohol) aqueous solution, or glycerin (or polyhydric alcohol) ethanol aqueous solution are mixed and stirred for about 20 to 90 minutes. Adsorption inclusion reaction of a degree.

If it is difficult to mix, it may be processed by emulsification using an emulsifier.
As another processing method, 100 grams of activated carbon powder is prepared by dissolving 300 grams of α, β, or γ cyclodextrin (cyclic oligosaccharide) in about 170 ml of water without using polyhydric alcohol or ethanol. May be mixed and stirred, subjected to inclusion reaction for about 30 to 120 minutes, and dried by freeze drying or the like.
Of course, a cyclodextrin aqueous solution, a polyhydric alcohol (such as glycerin) or water may be used in combination, and the polyalcohol (such as glycerin) may be adsorbed on the charcoal powder and mixed with the cyclodextrin aqueous solution.
Of course, at this time, polyhydric alcohol, cyclodextrin and activated carbon powder may be mixed and processed simultaneously.
Also, thoroughly mix and adsorb oil-soluble substances (vitamin E or A, or oils) to activated carbon, adsorb them, mix with a cyclodextrin (cyclic oligosaccharide) solution such as α, β, or γ, and wrap the mixture. A process for producing and processing reformable charcoal that is reacted is also good.
The modified activated carbon thus obtained can be used as medicinal charcoal or edible charcoal by filtration, if necessary, washed with water or other solvent, dried, or as it is.
In addition, it is diluted with an appropriate carrier or excipient, and optionally added with an appropriate additive (for example, a corrigent, a binder, a disintegrant, a surfactant), and a method known in the pharmaceutical or food production field. , As pharmaceuticals or health foods, powders, fine granules, granules, tablets, pills, soft capsules, hard capsules, bees, microcapsules, etc. It can be used in various forms such as a suspension suspension.
Here, the health food means a food that is more aggressive than normal food and is taken for the purpose of human or animal health, health maintenance, promotion, or the like.
Furthermore, these activated carbons can be used as health foods by adding them to foods.
For example, liquid or semi-solid, solid products, specifically, cookies, rice crackers, jelly, yokan, yogurt, manju, cream puff, ice cream, etc. , Miso, soy sauce, seasonings such as sauce, buckwheat, udon, pasta, noodles such as Chinese noodles (ramen), odorous natto, kusaya and other foods.
It may also be food for animals such as bed food or beef jerky.
Alternatively, the activated carbon may be added to the final product by mixing, applying, spraying, etc. to make it a health food, or when eating these foods, the activated carbon powder may be sprinkled and eaten together. .
Next, an example of a novel health food-like processing method in which functionality and flavor are remarkably improved as compared with conventional products by blending the present plan and modified activated carbon powder will be described.

1 g to 2 g of the modified activated carbon powder of the present plan is mixed and suspended in 100 ml of seasoning such as soy sauce or sauce, and filled into a plastic bottle, a bottle or the like.
By this method, the antioxidant effect of the seasoning, storage stability is increased and the quality is improved, and these seasonings are sprinkled or mixed with raw food, sashimi, natto, kusaya and other flavorful foods. Odor disappears, making it much easier to eat.

  At the time of processing of natto products, 100g of natto is originally mixed with 1g to 3g of the finest mesh of the modified activated carbon powder as much as possible. After blending, filling the container and sealing it will eliminate the odor of natto, prevent oxidation of the product, and stabilize the storage.

To 100 g of wheat flour and 50 g of saline, 2 g of the modified activated carbon powder (fine mesh) of the present invention is uniformly added, blended and mixed, stretched into a flat plate shape, cut into strips, and processed into a udon.
Since buckwheat and senbei can be processed in the same manner as this method, for example, if it is applied to the Arima specialty tansan rice cracker, the “Arima tansan bamboo charcoal health senbei” or the like will have a great PR effect.

  5 g of modified activated carbon powder having a fine mesh is mixed with 100 g of chocolate and processed into a plate shape or the like.

5 g of modified activated carbon powder is mixed with 100 g of gum base and processed into a plate-like gum.
This makes it possible to use the activated carbon as appropriate for oral hygiene in a suitable form.
The edible activated carbon powder can be processed into an easy-to-eat form by the method as described above, and the activated carbon can be ingested in a normal food sense.

The invention's effect

When charcoal powder is ingested by the body, the conventional charcoal powder has a jagged surface and a large contact surface.
In order to remedy this physical defect, glycerin (or other polyhydric alcohol) is adsorbed extensively near the surface of the charcoal molecules in the porous strong adsorption pores of activated carbon, and does not stick to the intestinal inner wall and flows through. Improves the properties, and does not interfere with the adsorptive power of the activated carbon and other effects.
In addition, even when cyclodextrin and activated carbon are mixed and stirred and clathrated, the flowability of the charcoal powder is improved and the usefulness of the charcoal powder is not hindered.
In addition, α-cyclodextrin has been recognized as a relatively favorable health benefit at present, and blood glucose level suppression / intestinal regulation and inflammatory cytokine expression suppression have been confirmed. In 2004, allergic diseases were improved. The effect was announced, and neutral fat and cholesterol reduction reduction effect, constipation improvement effect is demonstrated.
The former method of adsorbing a small amount of glycerin has a favorable and safe constipation effect, and the usefulness as a healthy diet supplement is recognized because of the far-infrared and negative ion effects of the activated carbon powder.

Claims (11)

  A method for producing and processing modified activated carbon obtained by mixing granular or powdered activated carbon with a solution such as polyhydric alcohol or water under normal pressure or under pressure, and adsorbing and bonding to a coal char.   A method for producing modified activated carbon obtained by mixing granular or powdered activated carbon with polyhydric alcohol at normal pressure or under pressure, and adsorbing and bonding polyhydric alcohol to the charcoal end pores.   The method according to claim 1, wherein the polyhydric alcohol or the aqueous solution of the polyhydric alcohol is glycerin or an aqueous solution of glycerin.   The method according to claim 1, wherein the solution is an aqueous solution of a polyhydric alcohol or an aqueous solution containing 5% to 30% by weight of a polyhydric alcohol.   The method according to claim 1 or 2, wherein the polyhydric alcohol ethanol solution or alcohol solution is an aqueous glycerin ethanol solution or an aqueous glycerin alcohol solution.   A process for producing modified activated carbon obtained by mixing and stirring an activated carbon in an aqueous solution of cyclodextrin (cyclic oligosaccharide) such as α, β, or γ, and including the mixture.   An aqueous solution of cyclodextrin (cyclic oligosaccharide) such as α, β, or γ is mixed with activated carbon powder and a polyhydric alcohol (such as glycerin) or a polyhydric alcohol solution (mainly an aqueous solution) or with activated carbon powder. A process for producing modified activated carbon obtained by mixing, stirring, adsorbing and enclosing with a mixture of a polyhydric alcohol (such as glycerin) or a polyhydric alcohol solution (mainly an aqueous solution).   A process for producing modified activated carbon obtained by substituting the fatty acid or fatty acid for the polyhydric alcohol (mainly glycerin) or an aqueous solution thereof in claim 1 with mixing, stirring, adsorption and inclusion.   The polyhydric alcohol (mainly glycerin) or an aqueous solution thereof in the sentence according to claims 1 to 7 is added with polyhydric alcohol (mainly glycerin) or an aqueous solution thereof and fatty oil (or fatty acid), mixed and stirred, adsorbent packaging Manufacturing process for modified activated carbon in contact.   Production of reforming charcoal by adsorbing oil-soluble substances (vitamin E or A, or oils) on activated carbon and mixing and stirring with an aqueous solution of cyclodextrin such as α, β, or γ. Processing method.   Processed food in which the present plan and modified activated carbon obtained by the method according to claim 1 are added to and blended with food.