WO2012107241A3 - Magnetoaktives oder elektroaktives kompositmaterial, dessen verwendung und verfahren zur beeinflussung von auf dem magnetoaktiven oder elektroaktiven kompositmaterial angelagerten biologischen zellen - Google Patents

Magnetoaktives oder elektroaktives kompositmaterial, dessen verwendung und verfahren zur beeinflussung von auf dem magnetoaktiven oder elektroaktiven kompositmaterial angelagerten biologischen zellen Download PDF

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Publication number
WO2012107241A3
WO2012107241A3 PCT/EP2012/000617 EP2012000617W WO2012107241A3 WO 2012107241 A3 WO2012107241 A3 WO 2012107241A3 EP 2012000617 W EP2012000617 W EP 2012000617W WO 2012107241 A3 WO2012107241 A3 WO 2012107241A3
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WO
WIPO (PCT)
Prior art keywords
active
magneto
electro
composite material
biological cells
Prior art date
Application number
PCT/EP2012/000617
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English (en)
French (fr)
Other versions
WO2012107241A2 (de
Inventor
Jörn PROBST
Holger Böse
Raman RABINDRANATH
Günther SCHLUNCK
Gareth MONKMANN
Mikhail Chamonine
Eva FORSTER
Matthias Mayer
Alexander BENTZ
Original Assignee
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
Hochschule Regensburg
Julius-Maximilians-Universität Würzburg
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Application filed by Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Hochschule Regensburg, Julius-Maximilians-Universität Würzburg filed Critical Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
Priority to EP12704688.6A priority Critical patent/EP2673360A2/de
Publication of WO2012107241A2 publication Critical patent/WO2012107241A2/de
Publication of WO2012107241A3 publication Critical patent/WO2012107241A3/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/04—Coating
    • C08J7/0427—Coating with only one layer of a composition containing a polymer binder
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/04—Coating
    • C08J7/043—Improving the adhesiveness of the coatings per se, e.g. forming primers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/04—Coating
    • C08J7/046—Forming abrasion-resistant coatings; Forming surface-hardening coatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/06—Magnetic means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/087—Acrylic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/093—Polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers
    • C08J2300/14—Water soluble or water swellable polymers, e.g. aqueous gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers
    • C08J2300/26—Elastomers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
    • C08J2333/24—Homopolymers or copolymers of amides or imides
    • C08J2333/26—Homopolymers or copolymers of acrylamide or methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2383/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon only; Derivatives of such polymers
    • C08J2383/04—Polysiloxanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2489/00—Characterised by the use of proteins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2489/00—Characterised by the use of proteins; Derivatives thereof
    • C08J2489/04—Products derived from waste materials, e.g. horn, hoof or hair
    • C08J2489/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Mechanical Engineering (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

Die Erfindung betrifft biokompatible, weiche, magnetoaktive Polymere (MAP), deren elastomechanische Eigenschaften durch ein Magnetfeld eingestellt werden können. Außerdem betrifft die Erfindung spezielle Magnetfeldsysteme zur lokalen Ansteuerung der MAP sowie die Bewegung, Trennung, Steuerung und Beeinflussung von biologischen Zellen an der Oberfläche des MAP-Materials.
PCT/EP2012/000617 2011-02-09 2012-02-09 Magnetoaktives oder elektroaktives kompositmaterial, dessen verwendung und verfahren zur beeinflussung von auf dem magnetoaktiven oder elektroaktiven kompositmaterial angelagerten biologischen zellen WO2012107241A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP12704688.6A EP2673360A2 (de) 2011-02-09 2012-02-09 Magnetoaktives oder elektroaktives kompositmaterial, dessen verwendung und verfahren zur beeinflussung von auf dem magnetoaktiven oder elektroaktiven kompositmaterial angelagerten biologischen zellen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011010757A DE102011010757B4 (de) 2011-02-09 2011-02-09 Magnetoaktives oder elektroaktives Kompositmaterial, dessen Verwendung und Verfahren zur Beeinflussung von auf dem magnetoaktiven oder elektroaktiven Kompositmaterial angelagerten biologischen Zellen
DE102011010757.6 2011-02-09

Publications (2)

Publication Number Publication Date
WO2012107241A2 WO2012107241A2 (de) 2012-08-16
WO2012107241A3 true WO2012107241A3 (de) 2012-11-08

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PCT/EP2012/000617 WO2012107241A2 (de) 2011-02-09 2012-02-09 Magnetoaktives oder elektroaktives kompositmaterial, dessen verwendung und verfahren zur beeinflussung von auf dem magnetoaktiven oder elektroaktiven kompositmaterial angelagerten biologischen zellen

Country Status (3)

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EP (1) EP2673360A2 (de)
DE (1) DE102011010757B4 (de)
WO (1) WO2012107241A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102014222832A1 (de) * 2014-11-10 2016-05-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Linearaktor und dessen Verwendung
KR102488143B1 (ko) 2015-05-27 2023-01-16 바스프 에스이 자성 코어를 제조하기 위한 조성물 및 상기 조성물의 제조 방법
WO2018104357A1 (en) 2016-12-09 2018-06-14 Koninklijke Philips N.V. Actuator device and method
DE102016224712A1 (de) * 2016-12-12 2018-06-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Aktorsubstrat, Verwendung zur Stimulation von biologischen Zellen und Verfahren zu dessen Herstellung
WO2019213093A1 (en) 2018-04-30 2019-11-07 Rutgers, The State University Of New Jersey Expandable arrays and methods of use

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US6476113B1 (en) * 2000-06-07 2002-11-05 Remington Products Company Magnetically active flexible polymers
DE10108857A1 (de) * 2001-02-14 2002-09-19 Hans-Dieter Hunger Bioaktive und biokompatible Konjugate mit magnetischen Eigenschaften und Verfahren zu deren Herstellung
US7976823B2 (en) * 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US20090092837A1 (en) * 2006-03-30 2009-04-09 Ge Healthcare Bio-Sciences Ab Magnetic beads
DE102009001769A1 (de) * 2008-03-28 2009-10-01 Basf Se Magnetorheologische Elastomere

Non-Patent Citations (4)

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ADELE M DOYLE ET AL: "Human Mesenchymal Stem Cells Form Multicellular Structures in Response to Applied Cyclic Strain", ANNALS OF BIOMEDICAL ENGINEERING, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 37, no. 4, 30 January 2009 (2009-01-30), pages 783 - 793, XP019668341, ISSN: 1573-9686 *
BOESE H: "VISCOELASTIC PROPERTIES OF SILICONE-BASED MAGNETORHEOLOGICAL ELASTOMERS", INTERNATIONAL JOURNAL OF MODERN PHYSICS C, WORLD SCIENTIFIC PUBL. CO., LONDON, GB, vol. 21, no. 28-29, 10 November 2007 (2007-11-10), pages 4790 - 4797, XP008151775, ISSN: 0129-1831, DOI: 10.1142/9789812771209_0008 *
CLYNE ET AL: "Mechanical and magnetic properties of metal fibre networks, with and without a polymeric matrix", COMPOSITES SCIENCE AND TECHNOLOGY, ELSEVIER, UK, vol. 65, no. 15-16, 1 December 2005 (2005-12-01), pages 2492 - 2499, XP005148121, ISSN: 0266-3538, DOI: 10.1016/J.COMPSCITECH.2005.05.037 *
SHALAW FAWZI-GRANCHER ET AL: "Optimisation of Biochemical Condition and Substrates In Vitro for Tissue Engineering of Ligament", ANNALS OF BIOMEDICAL ENGINEERING, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 34, no. 11, 10 October 2006 (2006-10-10), pages 1767 - 1777, XP019446476, ISSN: 1573-9686, DOI: 10.1007/S10439-006-9180-Y *

Also Published As

Publication number Publication date
EP2673360A2 (de) 2013-12-18
DE102011010757A1 (de) 2012-08-09
DE102011010757B4 (de) 2012-09-13
WO2012107241A2 (de) 2012-08-16

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