WO2012093859A3 - 폴리사이클릭 펩타이드 화합물을 포함하는 항균용 조성물 및 이의 생산방법 - Google Patents

폴리사이클릭 펩타이드 화합물을 포함하는 항균용 조성물 및 이의 생산방법 Download PDF

Info

Publication number
WO2012093859A3
WO2012093859A3 PCT/KR2012/000097 KR2012000097W WO2012093859A3 WO 2012093859 A3 WO2012093859 A3 WO 2012093859A3 KR 2012000097 W KR2012000097 W KR 2012000097W WO 2012093859 A3 WO2012093859 A3 WO 2012093859A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition including
producing same
antifungal composition
peptide compound
strain
Prior art date
Application number
PCT/KR2012/000097
Other languages
English (en)
French (fr)
Other versions
WO2012093859A2 (ko
Inventor
김원곤
권윤주
손미진
Original Assignee
한국생명공학연구원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한국생명공학연구원 filed Critical 한국생명공학연구원
Priority to US13/978,488 priority Critical patent/US9854804B2/en
Publication of WO2012093859A2 publication Critical patent/WO2012093859A2/ko
Publication of WO2012093859A3 publication Critical patent/WO2012093859A3/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 항균 활성을 가지는 스트렙토마이세스 속(Streptomyces sp.) AN1542 균주(수탁번호 : KCTC 12113BP), 화학식 1 또는 화학식 2로 표시되는 화합물 또는 이를 생산하는 균주를 유효성분으로 포함하는 항균용 조성물, 및 상기 화합물의 제조방법을 제공한다. 본 발명의 화합물 또는 균주는 병원성 미생물 및 항생제 내성균에 대하여 강력한 항균 활성을 나타내며, 특히 MRSA, QRSA, VRSA 및 VRE에 대하여 강력한 항균 활성을 나타내므로 슈퍼박테리아에 의한 감염성 질환의 치료에 유용하게 사용할 수 있는 효과가 있다.
PCT/KR2012/000097 2011-01-04 2012-01-04 폴리사이클릭 펩타이드 화합물을 포함하는 항균용 조성물 및 이의 생산방법 WO2012093859A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/978,488 US9854804B2 (en) 2011-01-04 2012-01-04 Antifungal composition comprising polycyclic peptide compound and method for preparing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20110000492 2011-01-04
KR10-2011-0000492 2011-01-04

Publications (2)

Publication Number Publication Date
WO2012093859A2 WO2012093859A2 (ko) 2012-07-12
WO2012093859A3 true WO2012093859A3 (ko) 2012-11-08

Family

ID=46457849

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/000097 WO2012093859A2 (ko) 2011-01-04 2012-01-04 폴리사이클릭 펩타이드 화합물을 포함하는 항균용 조성물 및 이의 생산방법

Country Status (3)

Country Link
US (1) US9854804B2 (ko)
KR (1) KR101344083B1 (ko)
WO (1) WO2012093859A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101773059B1 (ko) * 2015-03-26 2017-08-31 한국생명공학연구원 면역 증진 및 항바이러스 활성을 가지는 클로스트리디움 부티리쿰 균주 및 이의 용도
CN113249231B (zh) * 2021-05-21 2022-08-02 中国医学科学院医药生物技术研究所 来源于极地来源真菌的抗革兰阳性菌化合物及其制备方法与应用
CN114317390A (zh) * 2021-12-24 2022-04-12 安徽大学 一种用于林可链霉基因工程菌的种子培养基及培养发酵生产林可霉素的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03264535A (ja) * 1990-03-13 1991-11-25 Sankyo Co Ltd ヒト免疫不全ウィルス感染症治療剤
US5140101A (en) * 1990-11-21 1992-08-18 Bristol-Myers Squibb Company Antiviral antibiotic BU-4344V
US6365571B1 (en) * 1998-04-30 2002-04-02 Noda Institute For Scientific Research FGF inhibitor, angiogenesis inhibitor and antitumor agent containing complestatin or its derivative as effective ingredient

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03264535A (ja) * 1990-03-13 1991-11-25 Sankyo Co Ltd ヒト免疫不全ウィルス感染症治療剤
US5140101A (en) * 1990-11-21 1992-08-18 Bristol-Myers Squibb Company Antiviral antibiotic BU-4344V
US6365571B1 (en) * 1998-04-30 2002-04-02 Noda Institute For Scientific Research FGF inhibitor, angiogenesis inhibitor and antitumor agent containing complestatin or its derivative as effective ingredient

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HARUO TANAKA ET AL.: "Chloropeptins, New Anti-HIV Antibiotics Inhibiting gp120-CD4 Binding from Streptomyces sp. I. Taxonomy, Fermentation, Isolation, and Physico-chemical Properties and Biological Activities", THE JOURNAL OF ANTIBIOTICS, vol. 50, no. 1, 1997, pages 58 - 65, XP002925771 *
HIROYUKI KOBAYASHI ET AL.: "Neuroprotectins A and B, Bicyclohexapeptides Protecing Chick Telencephalic Neurons form Excitotoxicity, I. Fermentation, Isolation, Physico-chemical properties and Biological Activity", THE JOURNAL OF ANTIBIOTICS, vol. 54, no. 12, 2001, pages 1013 - 1018 *
SHEO B. SINGH ET AL.: "The Complestatins as HIV-1 Integrase Inhibitors. Efficient Isolation, Structure Elucidation, and Inhibitory Activities of Isocomplestatin, Chloropeptin I, New Complestatins, A and B, and Acid- Hydrolysis Products of Chloropeptin I", JOURNAL OF NATURAL PRODUCTS, vol. 64, no. 7, 2001, pages 874 - 882, XP002265327, DOI: doi:10.1021/np000632z *

Also Published As

Publication number Publication date
WO2012093859A2 (ko) 2012-07-12
KR20120079455A (ko) 2012-07-12
US9854804B2 (en) 2018-01-02
US20140030242A1 (en) 2014-01-30
KR101344083B1 (ko) 2013-12-24

Similar Documents

Publication Publication Date Title
IN2014DN09358A (ko)
EP3598899A3 (en) Plant growth-promoting microbes and uses therefor
PH12015501172A1 (en) Composition comprising biological control agents
BR112013011263A2 (pt) "composição nematicida, e método para controlar nematódeos"
EP3243387A3 (en) Compositions comprising a biological control agent and an insecticide
MX2013011375A (es) Mezclas de plagicidas.
PH12014502655A1 (en) Composition comprising a biological control agent and a fungicide selected from inhibitors of the lipid membrane synthesis, the melanine biosynthesis, the nucleic acid synthesis or the signal transduction
WO2014028520A8 (en) Bacillus megaterium bioactive compositions and metabolites
NZ701895A (en) Strains of lactobacillus with antifungal properties
PH12015501233A1 (en) Composition comprising a biological control agent and a fungicide
EP3363289A3 (en) Compositions comprising a biological control agent and an insecticide
WO2012003474A3 (en) Compositions and methods related to protein a (spa) variants
NZ594019A (en) Novel antibacterial agents for the treatment of gram positive infections
WO2013126387A3 (en) Composition comprising fermentation products from bacillus subtilis
WO2010085795A3 (en) Novel pasteuria strain
MX356530B (es) Composicion que comprende un agente de control biologico y un fungicida seleccionado de inhibidores de la biosintesis de aminoacidos o proteinas, inhibidores de la produccion de atp e inhibidores de la sintesis de la pared celular.
MX2010007677A (es) Derivados de hidroximoil-tetrazol como fungicidas.
CA2710814C (en) Bacterial ghost (bg) production process using betapropiolactone (blp) for final inactivation
NZ701896A (en) Strains of propionibacterium
WO2009090394A3 (en) Composition containing capsicum for treating a skin disorder
MX2012007541A (es) Derivados de hidroximoil-heterociclos fungicidas.
WO2011019995A3 (en) Synthesis and identification of novel rsk-specific inhibitors
WO2013041663A3 (de) Modifizierte apidaecinderivate als antibiotische peptide
WO2012093859A3 (ko) 폴리사이클릭 펩타이드 화합물을 포함하는 항균용 조성물 및 이의 생산방법
WO2012093855A3 (ko) 신규한 프라비마이신 화합물, 이를 포함하는 항균용 조성물 및 이의 생산방법

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12732114

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 13978488

Country of ref document: US

122 Ep: pct application non-entry in european phase

Ref document number: 12732114

Country of ref document: EP

Kind code of ref document: A2