WO2012080703A1 - Composition pharmaceutique comprenant de l'imatinib - Google Patents

Composition pharmaceutique comprenant de l'imatinib Download PDF

Info

Publication number
WO2012080703A1
WO2012080703A1 PCT/GB2011/001726 GB2011001726W WO2012080703A1 WO 2012080703 A1 WO2012080703 A1 WO 2012080703A1 GB 2011001726 W GB2011001726 W GB 2011001726W WO 2012080703 A1 WO2012080703 A1 WO 2012080703A1
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
solid oral
imatinib
oral pharmaceutical
composition according
Prior art date
Application number
PCT/GB2011/001726
Other languages
English (en)
Inventor
Geena Malhotra
Shrinivas Madhukar Purandare
Original Assignee
Cipla Limited
Turner, Craig Robert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Limited, Turner, Craig Robert filed Critical Cipla Limited
Publication of WO2012080703A1 publication Critical patent/WO2012080703A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Abstract

L'invention porte sur une composition pharmaceutique orale solide comprenant plus de 100 mg d'imatinib et un ou plusieurs excipients pharmaceutiquement acceptables. L'invention porte également sur un procédé pour la préparation d'une composition pharmaceutique comprenant plus de 100 mg d'imatinib et un ou plusieurs excipients pharmaceutiquement acceptables, comprenant la fabrication d'une composition pharmaceutique orale solide par granulation d'imatinib avec un ou plusieurs excipients pharmaceutiquement acceptables. L'invention porte également sur une composition pharmaceutique orale solide destinée à être utilisée en médecine comprenant plus de 100 mg d'imatinib et un ou plusieurs excipients pharmaceutiquement acceptables.
PCT/GB2011/001726 2010-12-15 2011-12-15 Composition pharmaceutique comprenant de l'imatinib WO2012080703A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3423MU2010 2010-12-15
IN3423/MUM/2010 2010-12-15

Publications (1)

Publication Number Publication Date
WO2012080703A1 true WO2012080703A1 (fr) 2012-06-21

Family

ID=45478346

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2011/001726 WO2012080703A1 (fr) 2010-12-15 2011-12-15 Composition pharmaceutique comprenant de l'imatinib

Country Status (1)

Country Link
WO (1) WO2012080703A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2497464A3 (fr) * 2011-03-09 2012-09-19 Adamed SP. Z O.O. Composition pharmaceutique de l'imatinibe methanesulphonate et son procédé de fabrication
EP2803352A1 (fr) 2013-05-14 2014-11-19 Hetero Research Foundation Compositions d'imatinib
EP3019159A4 (fr) * 2013-07-09 2017-01-18 Shilpa Medicare Limited Compositions pharmaceutiques orales comprenant du mésylate d'imatinib
EP3257499A1 (fr) 2016-06-17 2017-12-20 Vipharm S.A. Procédé pour la préparation de capsules de méthanesulfonate d'imatinib

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
WO2006040779A2 (fr) * 2004-10-11 2006-04-20 Natco Pharma Limited Formule à matrice flottante gastrique à libération contrôlée contenant la substance imatinib
WO2006121941A2 (fr) * 2005-05-10 2006-11-16 Novartis Ag Compositions pharmaceutiques comprenant l'imatinibe et un retardateur de liberation
EP1762230A1 (fr) * 2005-08-15 2007-03-14 Siegfried Generics International AG Tablette enrobé ou granulate comprenante un pyridylpyrimidine
EP2000139A1 (fr) * 2007-06-07 2008-12-10 Novartis AG Formes amorphes stabilisées du mésylate de l'imatinib
WO2009100176A2 (fr) 2008-02-07 2009-08-13 Abbott Laboratories Forme pharmaceutique pour administration orale d’un inhibiteur de tyrosine kinase
WO2010057020A2 (fr) * 2008-11-13 2010-05-20 Modgene, Llc Modification de charge d’amyloïde bêta dans du tissu non cérébral

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
WO2006040779A2 (fr) * 2004-10-11 2006-04-20 Natco Pharma Limited Formule à matrice flottante gastrique à libération contrôlée contenant la substance imatinib
WO2006121941A2 (fr) * 2005-05-10 2006-11-16 Novartis Ag Compositions pharmaceutiques comprenant l'imatinibe et un retardateur de liberation
EP1888040A2 (fr) 2005-05-10 2008-02-20 Novartis AG Compositions pharmaceutiques comprenant l'imatinibe et un retardateur de liberation
EP1762230A1 (fr) * 2005-08-15 2007-03-14 Siegfried Generics International AG Tablette enrobé ou granulate comprenante un pyridylpyrimidine
US20110206827A1 (en) 2005-08-15 2011-08-25 Siegfried Generics International Ag Film-coated tablet or granules containing as active ingredient a pyridylpyrimidine compound or a pharmaceutically acceptable salt of this compound
EP2000139A1 (fr) * 2007-06-07 2008-12-10 Novartis AG Formes amorphes stabilisées du mésylate de l'imatinib
WO2009100176A2 (fr) 2008-02-07 2009-08-13 Abbott Laboratories Forme pharmaceutique pour administration orale d’un inhibiteur de tyrosine kinase
WO2010057020A2 (fr) * 2008-11-13 2010-05-20 Modgene, Llc Modification de charge d’amyloïde bêta dans du tissu non cérébral

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
IVO ABRAHAM ET AL., BLOOD, 6 April 2009 (2009-04-06)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2497464A3 (fr) * 2011-03-09 2012-09-19 Adamed SP. Z O.O. Composition pharmaceutique de l'imatinibe methanesulphonate et son procédé de fabrication
EP2803352A1 (fr) 2013-05-14 2014-11-19 Hetero Research Foundation Compositions d'imatinib
EP3019159A4 (fr) * 2013-07-09 2017-01-18 Shilpa Medicare Limited Compositions pharmaceutiques orales comprenant du mésylate d'imatinib
EP3257499A1 (fr) 2016-06-17 2017-12-20 Vipharm S.A. Procédé pour la préparation de capsules de méthanesulfonate d'imatinib

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