WO2012064146A3 - Ｇｋｎ １을 함유하는 항암용 조성물 - Google Patents

Ｇｋｎ １을 함유하는 항암용 조성물 Download PDF

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Publication number
WO2012064146A3
WO2012064146A3 PCT/KR2011/008605 KR2011008605W WO2012064146A3 WO 2012064146 A3 WO2012064146 A3 WO 2012064146A3 KR 2011008605 W KR2011008605 W KR 2011008605W WO 2012064146 A3 WO2012064146 A3 WO 2012064146A3
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gkn
composition containing
anticancer
anticancer composition
outstanding
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PCT/KR2011/008605
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English (en)
French (fr)
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WO2012064146A9 (ko
WO2012064146A2 (ko
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박원상
윤정환
Original Assignee
가톨릭대학교 산학협력단
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Priority to CN2011800546195A priority Critical patent/CN103209702A/zh
Priority to EP11839104.4A priority patent/EP2641610A4/en
Publication of WO2012064146A2 publication Critical patent/WO2012064146A2/ko
Publication of WO2012064146A9 publication Critical patent/WO2012064146A9/ko
Publication of WO2012064146A3 publication Critical patent/WO2012064146A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57446—Specifically defined cancers of stomach or intestine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

본 발명은 GKN 1을 유효성분으로 함유하는 항암용 조성물에 관한 것으로서, 보다 구체적으로는 항암 활성이 우수한 GKN 1 유전자를 포함하는 발현벡터 또는 GKN 1 단백질을 유효성분으로 함유하는 항암용 조성물에 관한 것이다. 본 발명에 따른 GKN 1은 암세포의 발생을 억제하는 활성이 우수할 뿐만 아니라, 과발현시 암 세포의 전이를 억제하는 활성도 우수한 특징이 있으므로 항암 치료용 조성물로 유용하게 사용될 수 있는 효과가 있다.
PCT/KR2011/008605 2010-11-12 2011-11-11 Ｇｋｎ １을 함유하는 항암용 조성물 WO2012064146A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN2011800546195A CN103209702A (zh) 2010-11-12 2011-11-11 含有gkn1的抗癌用组合物
EP11839104.4A EP2641610A4 (en) 2010-11-12 2011-11-11 ANTICANCER COMPOSITION CONTAINING GKN 1

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0112610 2010-11-12
KR1020100112610A KR101215069B1 (ko) 2010-11-12 2010-11-12 Ｇｋｎ １을 함유하는 항암용 조성물

Publications (3)

Publication Number Publication Date
WO2012064146A2 WO2012064146A2 (ko) 2012-05-18
WO2012064146A9 WO2012064146A9 (ko) 2012-08-02
WO2012064146A3 true WO2012064146A3 (ko) 2012-08-23

Family

ID=46051452

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/008605 WO2012064146A2 (ko) 2010-11-12 2011-11-11 Ｇｋｎ １을 함유하는 항암용 조성물

Country Status (4)

Country Link
EP (1) EP2641610A4 (ko)
KR (1) KR101215069B1 (ko)
CN (1) CN103209702A (ko)
WO (1) WO2012064146A2 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101394828B1 (ko) * 2012-08-07 2014-05-13 가톨릭대학교 산학협력단 항암활성을 갖는 ｇｋｎ１의 아미노 말단 조절 모티프의 용도
KR101385357B1 (ko) * 2012-08-07 2014-04-14 가톨릭대학교 산학협력단 항암 활성을 갖는 ＧＫＮ１ ｂｒｉｃｈｏｓ 도메인의 용도
EP3284476B1 (en) 2012-12-19 2019-09-25 Lumen Bio LLC Uses of a gastrokine protein
KR102256159B1 (ko) 2014-11-06 2021-05-26 가톨릭대학교 산학협력단 Ｇｋｎ１을 유효성분으로 포함하는 자가면역질환의 예방 또는 치료용 조성물
KR101803636B1 (ko) 2015-03-31 2017-12-01 가톨릭대학교 산학협력단 Ssu72를 유효성분으로 포함하는 자가면역질환의 예방 또는 치료용 조성물
WO2019035602A2 (ko) * 2017-08-16 2019-02-21 가톨릭대학교 산학협력단 혈액 내 gkn1 단백을 이용하는 위암 진단
KR101988120B1 (ko) 2017-08-21 2019-09-27 가톨릭대학교 산학협력단 혈액 내 gastrokine 1 단백을 이용하는 위암 진단
KR101988118B1 (ko) * 2017-08-16 2019-06-11 가톨릭대학교 산학협력단 Gkn1 단백을 포함하는 항암 조성물
KR102430127B1 (ko) 2019-10-24 2022-08-11 가톨릭대학교 산학협력단 인테그린 알파 6 와 알파 x를 포함하는 암 예방 또는 치료용 조성물

Citations (2)

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WO2006037521A1 (de) * 2004-10-01 2006-04-13 B.R.A.H.M.S Aktiengesellschaft Bestimmung von gastrokine 1 (gkn1) als biomarker für entzündungen und infektionen
US20100113356A1 (en) * 2001-03-29 2010-05-06 The University Of Chicago Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors

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Patent Citations (2)

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US20100113356A1 (en) * 2001-03-29 2010-05-06 The University Of Chicago Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors
WO2006037521A1 (de) * 2004-10-01 2006-04-13 B.R.A.H.M.S Aktiengesellschaft Bestimmung von gastrokine 1 (gkn1) als biomarker für entzündungen und infektionen

Non-Patent Citations (3)

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KARIN A. OIEN ET AL.: "Gsatrokine 1 is abundantly and specifically expressed in superficial gastric epithelium, down-regulated in gastric carcinoma, and shows high evolutionary conservation", JOURNAL OF PATHOLOGY, vol. 203, 2004, pages 789 - 797, XP055116238 *
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Also Published As

Publication number Publication date
EP2641610A4 (en) 2014-12-31
CN103209702A (zh) 2013-07-17
EP2641610A2 (en) 2013-09-25
WO2012064146A9 (ko) 2012-08-02
KR101215069B1 (ko) 2012-12-24
WO2012064146A2 (ko) 2012-05-18
KR20120051258A (ko) 2012-05-22

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