WO2012064130A3 - 대장 선택성 셀레콕시브 전구체 화합물 및 이를 유효성분으로 함유하는 대장성 질환 치료 또는 예방용 약학조성물 - Google Patents
대장 선택성 셀레콕시브 전구체 화합물 및 이를 유효성분으로 함유하는 대장성 질환 치료 또는 예방용 약학조성물 Download PDFInfo
- Publication number
- WO2012064130A3 WO2012064130A3 PCT/KR2011/008571 KR2011008571W WO2012064130A3 WO 2012064130 A3 WO2012064130 A3 WO 2012064130A3 KR 2011008571 W KR2011008571 W KR 2011008571W WO 2012064130 A3 WO2012064130 A3 WO 2012064130A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- celecoxib
- treating
- pharmaceutical composition
- active ingredient
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
Abstract
본 발명은 셀레콕시브 전구체 화합물 및 이를 유효성분으로 함유하는 대장성 질환 치료 또는 예방용 약학조성물에 관한 것으로, 보다 상세하게는 대장성 질환의 치료 또는 예방에 COX-2 저해제인 셀레콕시브를 활용하기 위하여 위 및 소장에서는 흡수되지 않고 안정한 상태로 존재하며, 대장에서 효소에 의해 대사되어 약리효과를 발휘할 수 있는 셀레콕시브 전구체 화합물 및 이를 유효성분으로 함유하는 대장성 질환 치료 또는 예방용 약학조성물에 관한 것이다.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020100112171A KR101245078B1 (ko) | 2010-11-11 | 2010-11-11 | 대장 선택성 셀레콕시브 전구체 화합물 및 이를 유효성분으로 함유하는 대장성 질환 치료 또는 예방용 약학조성물 |
KR10-2010-0112171 | 2010-11-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012064130A2 WO2012064130A2 (ko) | 2012-05-18 |
WO2012064130A3 true WO2012064130A3 (ko) | 2012-07-19 |
Family
ID=46051437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2011/008571 WO2012064130A2 (ko) | 2010-11-11 | 2011-11-10 | 대장 선택성 셀레콕시브 전구체 화합물 및 이를 유효성분으로 함유하는 대장성 질환 치료 또는 예방용 약학조성물 |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR101245078B1 (ko) |
WO (1) | WO2012064130A2 (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9562015B2 (en) * | 2011-11-17 | 2017-02-07 | The Regents Of The University Of Colorado, A Body | Methods and compositions for enhanced drug delivery to the eye and extended delivery formulations |
CN107540726A (zh) * | 2017-08-22 | 2018-01-05 | 河北科技大学 | 一类肽基塞来昔布衍生物及其应用 |
CN113144212B (zh) * | 2021-03-15 | 2022-02-11 | 上海英诺富成生物科技有限公司 | 一种塞来昔布的前体药物及其制备方法与应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100255087A1 (en) * | 2007-04-04 | 2010-10-07 | Ivan Coulter | oral pharmaceutical composition |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040092566A1 (en) * | 2002-11-12 | 2004-05-13 | Graneto Matthew J. | Celecoxib prodrug |
ES2337915T3 (es) * | 2004-10-27 | 2010-04-30 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Conjugados con adtividad antiinflamatoria. |
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2010
- 2010-11-11 KR KR1020100112171A patent/KR101245078B1/ko active IP Right Grant
-
2011
- 2011-11-10 WO PCT/KR2011/008571 patent/WO2012064130A2/ko active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100255087A1 (en) * | 2007-04-04 | 2010-10-07 | Ivan Coulter | oral pharmaceutical composition |
Non-Patent Citations (4)
Title |
---|
PRABHAT K. SHRIVASTAVA ET AL.: "Dextran carrier macromolecular for colon specific delivery of celecoxib", CURRENT DRUG DELIVERY, vol. 7, no. 2, April 2010 (2010-04-01), pages 144 - 151 * |
V. R. SHINHA ET AL.: "Development of pulsatile systems for targeted drug delivery of celecoxib for prophylaxis of colorectal cancer", DRUG DELIVERY, vol. 13, no. 3, 2006, pages 221 - 225 * |
Y.S.R. KRISHNAIAH ET AL.: "In vivo evaluation of guargum-based colon-targeted oral drug delivery systems of celecoxib in human volunteers", EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, vol. 27, no. 4, 2002, pages 273 - 280 * |
YUBJIN JUNG ET AL.: "What should be considered on design of a colon-specific prodrug?", EXPERT OPINION ON DRUG DELIVERY, vol. 7, no. 2, February 2010 (2010-02-01), pages 245 - 258 * |
Also Published As
Publication number | Publication date |
---|---|
WO2012064130A2 (ko) | 2012-05-18 |
KR20120050759A (ko) | 2012-05-21 |
KR101245078B1 (ko) | 2013-03-18 |
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