WO2012058297A3 - Dispositifs actionnables contenant un agent de chimionucléolyse - Google Patents

Dispositifs actionnables contenant un agent de chimionucléolyse Download PDF

Info

Publication number
WO2012058297A3
WO2012058297A3 PCT/US2011/057868 US2011057868W WO2012058297A3 WO 2012058297 A3 WO2012058297 A3 WO 2012058297A3 US 2011057868 W US2011057868 W US 2011057868W WO 2012058297 A3 WO2012058297 A3 WO 2012058297A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemonucleolysis agent
devices
intervertebral disc
chemonucleolysis
methods
Prior art date
Application number
PCT/US2011/057868
Other languages
English (en)
Other versions
WO2012058297A2 (fr
Inventor
Elaine Lee
Original Assignee
Kyphon Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyphon Sarl filed Critical Kyphon Sarl
Publication of WO2012058297A2 publication Critical patent/WO2012058297A2/fr
Publication of WO2012058297A3 publication Critical patent/WO2012058297A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/441—Joints for the spine, e.g. vertebrae, spinal discs made of inflatable pockets or chambers filled with fluid, e.g. with hydrogel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3415—Trocars; Puncturing needles for introducing tubes or catheters, e.g. gastrostomy tubes, drain catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/444—Intervertebral or spinal discs, e.g. resilient for replacing the nucleus pulposus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/4445—Means for culturing intervertebral disc tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des dispositifs et des procédés efficaces qui utilisent un agent de chimionucléolyse dans le traitement d'un disque intervertébral ou le traitement de l'arachnoïdite spinale. Les dispositifs et les procédés comprennent un agent de chimionucléolyse qui dégrade ou contracte au moins une partie du disque intervertébral. Dans certains modes de réalisation, ces procédés et ces dispositifs sont conçus pour libérer immédiatement une quantité efficace de l'agent de chimionucléolyse dans un délai de 24 heures, lorsque le dispositif entre en contact direct ou indirect avec un activateur et pour assurer une libération prolongée de l'agent de chimionucléolyse sur une période pouvant atteindre un an, pour traiter le disque intervertébral. Dans certains modes de réalisation, l'agent de chimionucléolyse dans le dispositif est administré dans l'espace intrathécal et/ou le sac thécal ou à proximité de ces derniers pour traiter l'arachnoïdite spinale.
PCT/US2011/057868 2010-10-26 2011-10-26 Dispositifs actionnables contenant un agent de chimionucléolyse WO2012058297A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/911,988 US9414930B2 (en) 2010-10-26 2010-10-26 Activatable devices containing a chemonucleolysis agent
US12/911,988 2010-10-26

Publications (2)

Publication Number Publication Date
WO2012058297A2 WO2012058297A2 (fr) 2012-05-03
WO2012058297A3 true WO2012058297A3 (fr) 2012-07-05

Family

ID=45973626

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/057868 WO2012058297A2 (fr) 2010-10-26 2011-10-26 Dispositifs actionnables contenant un agent de chimionucléolyse

Country Status (2)

Country Link
US (1) US9414930B2 (fr)
WO (1) WO2012058297A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101464983B1 (ko) * 2008-05-01 2014-11-25 스파인셀 프러프라이어테리 리미티드 조직 보형물의 형성 및 삽입기구 및 그의 시스템 및 방법
US20130282121A1 (en) * 2012-03-22 2013-10-24 Ann Prewett Spinal facet augmentation implant and method
US9066853B2 (en) * 2013-01-15 2015-06-30 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
US10449055B2 (en) 2015-04-23 2019-10-22 Disc Fix L.L.C. Systems and methods for treatment of intervertebral disc derangements
CN108430535A (zh) * 2015-08-20 2018-08-21 芭芭拉·珀森斯 用于整形外科的一体化针和插管
US10285825B2 (en) * 2016-04-07 2019-05-14 Howmedica Osteonics Corp. Surgical insertion instruments
EP3456297B1 (fr) 2017-09-15 2023-10-04 Howmedica Osteonics Corp. Instruments pour implants intercorporels extensibles
WO2019159062A1 (fr) 2018-02-13 2019-08-22 Murphy Kieran P Système d'administration pour administrer une forme retard à un site cible sous guidage d'image, et méthodes et utilisations de celui-ci
US20190334176A1 (en) 2018-04-26 2019-10-31 Yeong Woo Kim Devices and methods for preparing a slurry and coating a substrate with a slurry

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719108A (en) * 1981-05-13 1988-01-12 Smith Laboratories, Inc. Chymopapain composition and method for its use
US20030181964A1 (en) * 1996-08-13 2003-09-25 Oratec Interventions, Inc. a Delaware corporation Method and apparatus for treating annular fissures in intervertebral discs
US20050234425A1 (en) * 2004-04-16 2005-10-20 Innospine, Inc. Spinal diagnostic methods and apparatus
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
US20070250044A1 (en) * 2006-04-24 2007-10-25 Sdgi Holdings, Inc. Controlled release systems and methods for intervertebral discs
US20080027554A1 (en) * 2006-07-31 2008-01-31 Talmadge Karen D Kit and methods of treatment of an intervertebral disc

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4624255A (en) 1982-02-18 1986-11-25 Schenck Robert R Apparatus for anastomosing living vessels
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5868789A (en) 1997-02-03 1999-02-09 Huebner; Randall J. Removable suture anchor apparatus
US5522844A (en) 1993-06-22 1996-06-04 Johnson; Lanny L. Suture anchor, suture anchor installation device and method for attaching a suture to a bone
US5626838A (en) 1995-03-13 1997-05-06 The Procter & Gamble Company Use of ketorolac for treatment of squamous cell carcinomas of the oral cavity or oropharynx
DE69632569T2 (de) 1995-06-09 2005-08-18 Euroceltique S.A. Formulierungen und verfahren für eine verlängerte lokalanästhesie
US5759583A (en) 1995-08-30 1998-06-02 Syntex (U.S.A.) Inc. Sustained release poly (lactic/glycolic) matrices
PT949905E (pt) 1996-12-20 2001-12-28 Alza Corp Composicao de gel injectavel de efeito retardado e processo para a sua preparacao
US6294170B1 (en) 1997-08-08 2001-09-25 Amgen Inc. Composition and method for treating inflammatory diseases
CN1332340C (zh) 1997-03-04 2007-08-15 石仓博 语言分析系统及方法
WO1998051290A2 (fr) 1997-05-16 1998-11-19 Children's Medical Center Corporation Formulations anesthesiques locales
KR100367144B1 (ko) 1997-07-02 2003-01-14 유로-셀티크 소시에떼 아노뉨 관절과 체강(ｂｏｄｙ ｓｐａｃｅ)내에서 연장된 마취
TW577758B (en) 1997-10-27 2004-03-01 Ssp Co Ltd Intra-articular preparation for the treatment of arthropathy
US6069129A (en) 1998-03-13 2000-05-30 Mrs, Llc Elastin derived composition and method of using same
DE69916045T2 (de) 1998-05-12 2004-08-05 Boston Scientific Ltd., St. Michael Hand betriebenes gerät zum setzen von knochenankern
US6451335B1 (en) * 1998-07-02 2002-09-17 Euro-Celtique S.A. Formulations and methods for providing prolonged local anesthesia
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6179862B1 (en) 1998-08-14 2001-01-30 Incept Llc Methods and apparatus for in situ formation of hydrogels
US6927044B2 (en) 1998-09-25 2005-08-09 Regeneron Pharmaceuticals, Inc. IL-1 receptor based cytokine traps
US6958149B2 (en) 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
US7572440B2 (en) 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
EP1117422B1 (fr) 1998-10-06 2005-09-28 Stryker Corporation Utilisation de op-1 pour la fabrication d'un medicament destine a la reparation de defauts du cartilage non-articulaire d'un mammifere
US6143314A (en) 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
US6565874B1 (en) 1998-10-28 2003-05-20 Atrix Laboratories Polymeric delivery formulations of leuprolide with improved efficacy
US6436099B1 (en) 1999-04-23 2002-08-20 Sdgi Holdings, Inc. Adjustable spinal tether
US6287588B1 (en) 1999-04-29 2001-09-11 Macromed, Inc. Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof
US7220281B2 (en) 1999-08-18 2007-05-22 Intrinsic Therapeutics, Inc. Implant for reinforcing and annulus fibrosis
US7951201B2 (en) 1999-10-20 2011-05-31 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US6461631B1 (en) 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
DE60033055D1 (de) 1999-12-06 2007-03-08 Warsaw Orthopedic Inc Bandscheibenbehandlungsvorrichtung
US6899716B2 (en) 2000-02-16 2005-05-31 Trans1, Inc. Method and apparatus for spinal augmentation
US6589549B2 (en) 2000-04-27 2003-07-08 Macromed, Incorporated Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
WO2002053128A2 (fr) * 2001-01-03 2002-07-11 Bausch & Lomb Incorporated Dispositifs d'administration de medicament a liberation prolongee pour la diffusion d'agents multiples
US7229441B2 (en) 2001-02-28 2007-06-12 Warsaw Orthopedic, Inc. Flexible systems for spinal stabilization and fixation
US8162816B2 (en) 2001-03-09 2012-04-24 Boston Scientific Scimed, Inc. System for implanting an implant and method thereof
IL142933A0 (en) 2001-05-03 2002-04-21 Dentis Technology Ltd Polymeric dental implant and method for use thereof
CN100515504C (zh) * 2001-10-12 2009-07-22 美国英佛曼公司 涂层,涂布体及其制造方法
MXPA01011542A (es) 2001-11-13 2003-05-22 Alcon Inc Regeneracion del cartilago articular da°ado por la osteoartritis de grado i y ii, mediante la aplicacion intra-articular de una mezcla de hialuronato de sodio y de condroitin sulfato en un vehiculo de gel.
US7595043B2 (en) * 2001-12-07 2009-09-29 Cytori Therapeutics, Inc. Method for processing and using adipose-derived stem cells
US6974462B2 (en) 2001-12-19 2005-12-13 Boston Scientific Scimed, Inc. Surgical anchor implantation device
US8133501B2 (en) * 2002-02-08 2012-03-13 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled drug delivery
US20040109893A1 (en) * 2002-06-25 2004-06-10 Guohua Chen Sustained release dosage forms of anesthetics for pain management
ES2601143T3 (es) 2002-07-19 2017-02-14 Omeros Corporation Copolímeros tribloque biodegradables, métodos de síntesis de los mismos, e hidrogeles y biomateriales preparados a partir de los mismos
US20040166088A1 (en) 2003-01-15 2004-08-26 Shalaby Shalaby W. Polymeric precursors of non-absorbable, in situ-forming hydrogels and applications thereof
MXPA05009429A (es) 2003-03-05 2005-12-12 Halozyme Inc Glicoproteina hialuronidasa soluble (shasegp), proceso para preparar la misma, usos y composiciones farmaceuticas que la comprenden.
US20090291112A1 (en) * 2003-05-16 2009-11-26 Truncale Katherine G Allograft osteochondral plug combined with cartilage particle mixture
US7144412B2 (en) 2003-06-25 2006-12-05 Wolf Medical Enterprises, Inc. Gold suture and method of use in wound closure
US7459713B2 (en) * 2003-08-14 2008-12-02 Microptix Technologies, Llc Integrated sensing system approach for handheld spectral measurements having a disposable sample handling apparatus
EP1529543A1 (fr) * 2003-11-04 2005-05-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Utilisation d'un hydrogel pour la culture de chondrocytes
CA2536041A1 (fr) 2003-11-10 2005-05-26 Angiotech International Ag Implants medicaux et agents inducteurs de fibrose
US20050175709A1 (en) 2003-12-11 2005-08-11 Baty Ace M.Iii Therapeutic microparticles
JP2007519756A (ja) 2004-01-30 2007-07-19 アンジオテック インターナショナル アーゲー 拘縮を治療するための組成物および方法
US7410480B2 (en) 2004-04-21 2008-08-12 Acclarent, Inc. Devices and methods for delivering therapeutic substances for the treatment of sinusitis and other disorders
US7361168B2 (en) 2004-04-21 2008-04-22 Acclarent, Inc. Implantable device and methods for delivering drugs and other substances to treat sinusitis and other disorders
US8512730B2 (en) 2004-07-12 2013-08-20 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
US20060206183A1 (en) * 2004-08-31 2006-09-14 Pyles Stephen T Spinal cord stimulator lead for neurostimulation having a fluid delivery lumen and/0r a distensible balloon
US20060074422A1 (en) 2004-09-27 2006-04-06 Story Brooks J Suture anchor and void filler combination
EP1827405A2 (fr) 2004-11-24 2007-09-05 Algorx Pharmaceuticals, Inc. Formulation a base de capsaicinoide en gel et utilisations afferentes
US7611494B2 (en) 2005-02-08 2009-11-03 Confluent Surgical, Inc. Spray for fluent materials
US20060183786A1 (en) 2005-02-16 2006-08-17 Chi Mei Foundation Hospital Injectable long-acting analgesic composition comprising an ester derivative of ketorolac
JP5008206B2 (ja) 2005-05-20 2012-08-22 オメロス コーポレイション シクロオキシゲナーゼインヒビターおよびカルシウムチャネルアンタゴニストの組成物、ならびに泌尿器科の処置において使用するための方法
US7610100B2 (en) 2005-12-30 2009-10-27 Boston Scientific Neuromodulation Corporation Methods and systems for treating osteoarthritis
US7741273B2 (en) 2006-04-13 2010-06-22 Warsaw Orthopedic, Inc. Drug depot implant designs
US20070253994A1 (en) 2006-04-28 2007-11-01 Medtronic, Inc. Intraspinal Drug Delivery Methods and Devices To Alleviate Chronic Pelvic Pain
US20080091207A1 (en) 2006-10-13 2008-04-17 Csaba Truckai Bone treatment systems and methods
EP2268805B1 (fr) 2008-03-06 2015-05-06 Halozyme, Inc. Production à grande échelle d'hyaluronidase soluble
TWI395593B (zh) 2008-03-06 2013-05-11 Halozyme Inc 可活化的基質降解酵素之活體內暫時性控制
US20100003238A1 (en) 2008-04-14 2010-01-07 Frost Gregory I Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions
US8652505B2 (en) * 2010-03-04 2014-02-18 Southwest Research Institute Coating for medical implants

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719108A (en) * 1981-05-13 1988-01-12 Smith Laboratories, Inc. Chymopapain composition and method for its use
US20030181964A1 (en) * 1996-08-13 2003-09-25 Oratec Interventions, Inc. a Delaware corporation Method and apparatus for treating annular fissures in intervertebral discs
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
US20050234425A1 (en) * 2004-04-16 2005-10-20 Innospine, Inc. Spinal diagnostic methods and apparatus
US20070250044A1 (en) * 2006-04-24 2007-10-25 Sdgi Holdings, Inc. Controlled release systems and methods for intervertebral discs
US20080027554A1 (en) * 2006-07-31 2008-01-31 Talmadge Karen D Kit and methods of treatment of an intervertebral disc

Also Published As

Publication number Publication date
US20120101577A1 (en) 2012-04-26
US9414930B2 (en) 2016-08-16
WO2012058297A2 (fr) 2012-05-03

Similar Documents

Publication Publication Date Title
WO2012058297A3 (fr) Dispositifs actionnables contenant un agent de chimionucléolyse
WO2007005453A3 (fr) Compositions destinees au traitement ou a la prevention de l'obesite et de troubles lies a la resistance a l'insuline
WO2008124675A3 (fr) Procédés de lutte contre les algues à l'aide de thaxtomine et compositions de thaxtomine
WO2012068549A3 (fr) Formulations d'agents thérapeutiques pour des dispositifs implantés
EP2037742A4 (fr) Prévention d'une détérioration tissulaire induite par rayonnement nucléaire, solaire et autre
WO2010132882A3 (fr) Compositions sublinguales de dexmédétomidine et leurs procédés d'utilisation
WO2012068541A3 (fr) Dispositifs de maintien de tissus et procédés d'utilisation
EP2605326A4 (fr) Système d'électrode à lit fluidisé, et procédé de traitement de stockage d'énergie et de traitement de l'eau à capacité élevée utilisant celui-ci
WO2008060359A3 (fr) Implants oculaires biodégradables, et procédés pour traiter des maladies de l'œil
WO2010002586A3 (fr) Compositions topiques contenant de l’isonicotinamide
WO2007084857A3 (fr) Procédés et compositions de traitement de troubles prolifératifs cellulaires
WO2008060626A3 (fr) Composés modulateurs de fonction trpv3
WO2012064667A3 (fr) Traitement d'addiction et de troubles de contrôle des impulsions au moyen d'inhibiteurs de la pde7
WO2011085162A3 (fr) Compositions topiques transdermiques de dexmédétomidine et leurs procédés d'utilisation
WO2013036513A3 (fr) Bandages médicaux dotés d'un matériau réducteur de l'adhérence à la peau
WO2007130612A3 (fr) Procédé permettant d'obtenir et de conserver des cellules souches multipotentielles
WO2010062059A3 (fr) Véhicule d'administration de cellules type hydrogel utilisé pour la cicatrisation et procédé de préparation associé
WO2011159840A3 (fr) Phénylthioacétates, compositions et procédés d'application
WO2008087643A3 (fr) Procédés permettant d'augmenter l'efficacité thérapeutique des inhibiteurs de la topoisomérase
EP2164978A4 (fr) Compositions et procédés pour moduler l'activité d'adamts13
WO2013001372A3 (fr) Procédés et compositions pour inhiber l'activation des lymphocytes t régulateurs
WO2010088450A3 (fr) Procédés de traitement de maladies associées à la modulation de serca
AP2011005849A0 (en) Methods of using and compositions comprising PDE4 modulations for treatment, prevention and management of tuberculosis.
WO2010015965A3 (fr) Procédés et compositions de traitement d'un dommage neuronal et de modulation de canaux potentiels de récepteurs transitoires
EP1951290A4 (fr) Agent pour utilisation dans le cas d'intolerance au fructose

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11837008

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11837008

Country of ref document: EP

Kind code of ref document: A2